Abstract: A pill pulverizing kit is a system that contains, processes, and subsequently dispenses pills and similar hard medications. The system includes a tubular receptacle, a crushed-pill repository, and a plurality of pill-processing devices. The tubular receptacle is a container utilized as the primary housing for pills both before and after pulverizing, as well as the housing for the components involved in crushing and consumption. The crushed-pill repository is a curved indent that collects and contains crushed pill material until the user is prepared to consume or serve the pill powder. The plurality of pill-processing devices relates to a series of removable additions to the tubular receptacle that provide various functions, including pill pulverization and content dispensing and consumption. The plurality of pill-processing devices includes a lid for consumption, as well as an impact driving mechanism that generates power and force for pulverizing pills.

Abstract: A medicine cassette includes a medicine supplier configured to supply accommodated medicines according to prescription information, a medicine delivery part configured to deliver the medicines supplied from the medicine supplier to a medicine discharge part, and the medicine discharge part configured to discharge the medicines, which are delivered through the medicine delivery part, to the outside. The medicine supplier may include a medicine accommodation part configured to accommodate the medicines and a rotating rotor part configured to deliver the medicines accommodated in the medicine accommodation part to the medicine delivery part. The rotating rotor part may include a rotating rotor, and at least one sliding member. The sliding member may be configured to be outwardly moved in the radial direction of the rotating rotor as the recess of the rotating rotor approaches a medicine supply inlet configured to supply the medicines to the medicine delivery part.

Abstract: A dispensing assembly, including a case including at least one aperture, a drive gear operatively arranged to engage the case, a tablet disc rotatably arranged in the case and including a plurality of compartments, and an electronics assembly, including a motor engaged with the drive gear, and a housing operatively arranged to engage the tablet disc, wherein the motor is arranged to rotate the electronics assembly and the tablet disc with respect to the case to align the plurality of compartments with the at least one aperture.

Abstract: The present application provides dental fillers, and methods of making and using dental fillers that include a treated surface that includes a phosphate salt. Dental compositions including such dental fillers can be useful for delivering ions to the oral environment. Dental compositions, and methods of using dental compositions that include a phosphate salt and a hardenable resin or a water-dispersible, polymeric film former are also provided.

Abstract: Disclosed is a dental adhesive including a polymeric adhesive and a nanofiller dispersed in the polymeric adhesive, the nanofiller being constituted by graphene nanostructures which are properly dispersed inside the polymer adhesive and over the surface of the adhesive layer without formation of agglomerates, so that the dental adhesive exhibits significant antimicrobial and antibiofilm properties against pathogens of the oral cavity.

Abstract: A preform intended for the production of a dental prosthesis. The preform includes a group of agglomerated ceramic, glass-ceramic or glass particles, such that, as volume percents: more than 40% and less than 90% of the particles of said group have a size greater than 0.5 ?m and less than 3,5 ?m, said particles hereinafter being denoted “enamel particles”, and more than 10% and less than 60% of the particles of said group have a size greater than 3.5 ?m and less than 5.5 ?m, said particles hereinafter being denoted “dentine particles.” The microstructure of the preform is such that there is an axis X, termed “axis of variation”, along which the Ve/(Ve+Vd) ratio changes continuously, Ve and Vd denoting the volume percents of enamel particles and of dentine particles, respectively. The enamel and dentine particles representing, together, more than 90% of the volume of the agglomerated particles.

Abstract: Described herein are thermoplastic denture frames having significantly improved lifetimes as well as comfort. The denture frames include a polymer composition including at least one poly(ether ether ketone) (“PEEK”) polymer and at least one polyphenylsulfone (“PPSU”) polymer. It was surprisingly discovered that the polymer compositions have significantly improved color stability, relative to corresponding polymer compositions including PEEK polymer as the only polymeric component of the polymer composition. Additionally, the polymer compositions have significantly improved toughness, flexibility and dimensional stability. The combination of the aesthetic characteristics and mechanical characteristics of the polymer compositions allows for denture frames having improved lifetimes and comfort.

Abstract: Provided is a remover set that allows an attraction head of a remover to easily drop down to the bottom of a holding hollow part of a remover stand, and excels in usability. The remover includes an attraction head having a magnet built therein; a root part connecting to the attraction head; and a grip part extending from the root part. The root part has a recessed portion recessed inward than its vicinity. The remover stand has a holding hollow part including a tip-holding portion that has a concave shape corresponding to a shape including a tip of the attraction head; an opening end part formed upward of the tip-holding portion; and a guide part that is arranged in a portion that is positioned between the tip-holding portion and the opening end part and faces the recessed portion, and is inclined inward as going upward from the tip-holding portion.

Abstract: The present invention is a dermal-exfoliation system that uses positive pressure to deliver salt and/or bio-inert crystalline particle abrasives or saline solution to the stratum corneum, combined with a minimal amount of negative pressure to close the loop when in contact with the skin to evacuate spent particles and dislodged skin cells and debris. An applicator handpiece is optimized for the use of the combined pressure system discussed herein for the removal of epidermal layers.

Abstract: The present invention relates to a peel-off facial mask cosmetic composition, comprising: a liquid-phase first reagent containing purified water and a liquid-phase second reagent containing an oily emollient, a surfactant, a gel forming agent, a gelling agent and a gel retarder, wherein the gel forming agent, the gelling agent and the gel retarder contained in the second reagent are not gelled by the oily emollient and are present in an inactive state.

Abstract: Described herein, a conditioner composition can help to provide improved long-lasting odor benefit of the benefit agent containing polyacrylate microcapsules onto hair. The conditioner composition includes a combination of polyacrylate microcapsules, deposition polymers, conditioner agents, and a carrier.

Abstract: The present invention relates to a composition, especially a cosmetic composition, for caring for and/or making up keratin materials, comprising at least: a non-aqueous medium containing at least one hydrocarbon-based oil, particles of at least one polymer that is surface-stabilized with a stabilizer, the polymer of the particles being a C1-C4 alkyl (meth) acrylate polymer; the stabilizer being an isobornyl (meth)acrylate polymer chosen from isobornyl (meth)acrylate homopolymer and statistical copolymers of isobornyl (meth)acrylate and of C1-C4 alkyl (meth)acrylate present in an isobornyl (meth)acrylate/C1-C4 alkyl (meth)acrylate weight ratio of greater than 4; and a hydrophobic film-forming polymer chosen from block ethylenic copolymers and hydrocarbon-based resins, and. mixtures thereof.

Abstract: Disclosed herein are dentifrices comprising a zinc amino acid complex together with soluble phosphate salts. Methods of making and using the dentifrices are also provided.

Abstract: A composition for treating keratinous fibers is provided herein. The composition includes, relative to the weight thereof, from about 0.01 to about 4.00 wt % of at least one alum. The composition further includes, relative to the weight thereof, from about 0.01 to about 5.00 wt % of at least one salt which comprises a bivalent cation.

Abstract: A method of combating colour loss from a dyed material, the method comprising contacting the material with a composition comprising a hydroxy-substituted aldehyde.

Abstract: A method of treating a material, the method comprising contacting the material with a composition comprising an alpha-substituted aldehyde.

Abstract: A method of combatting colour loss from a dyed material, the method comprising contacting the material with a composition comprising an alpha-substituted aldehyde.

Abstract: A compound that has retinol like properties is used in compositions for treating the skin.

Abstract: The present invention relates to a composition for dyeing keratin fibres, in particular keratin fibres such as the hair, comprising: at least one oxidation base 3-(2,5-diaminophenyl)-1-propanol and/or acid salts thereof or solvates thereof; at least one oxidation base chosen from para-aminophenol, 3-methyl-4-aminophenol and N,N-bis(3-hydroxyethyl)-para-phenylenediamine, addition salts thereof, solvates thereof, and mixtures thereof; at least one coupler; optionally at least one fatty substance; optionally at least one basifying agent; and optionally at least one chemical oxidizing agent. The invention also relates to a process for dyeing keratin fibres such as the hair using the composition of the invention, and to a multi-compartment device for using the composition of the invention.

Abstract: A method for producing aqueous N-acyl amino acid solutions does not require any solid to be isolated and yields solutions that have a low impurity content. The corresponding aqueous N-acyl amino acid solutions can be used in cosmetic and pharmaceutical preparations. The solutions can include an alkaline metal or alkaline earth metal salt of capryloyl glycinic acid and/or undecenoyl glycinic acid.

Abstract: Methods of treating skin in need of treatment with retinoids are provided, which comprise cleansing the skin with a cleansing composition comprising a low irritation polymeric cleansing agent prior to treating with a retinoid. This improves the activity of the retinoid for treating for example signs of skin aging, acne, or rosacea.

Abstract: Methods of making personal care compositions, such as dentifrices, involving the addition of rheology modifiers at a later stage in the personal care composition formation process.

Abstract: A cosmetic agent for temporarily reshaping keratin fibers and a method for the same are provided herein. In one embodiment, the cosmetic agent includes, based on the total weight thereof, about 0.1 to about 2.0% by weight of at least one hydrophobically modified (meth)acrylic acid copolymer. The cosmetic agent includes, based on the total weight thereof, about 0.1 to about 6.0% by weight of at least one polyurethane/polyacrylate hybrid polymer. In another embodiment, the method includes applying a cosmetic agent to the keratin fibers. The cosmetic agent includes, based on the total weight thereof, about 0.1 to about 2.0% by weight of at least one hydrophobically modified (meth)acrylic acid copolymer. The cosmetic agent includes, based on the total weight thereof, about 0.1 to about 6.0% by weight of at least one polyurethane/polyacrylate hybrid polymer. The method includes temporarily imparting hold to the shape of the keratin-containing fibers.

Abstract: The present invention relates to a composition, especially a cosmetic composition, comprising: at least one aqueous phase gelled with at least one hydrophilic gelling agent, said hydrophilic gelling agent being at least one nonionic associative polymer, and at least one oily phase gelled with at least one lipophilic gelling agent, said lipophilic gelling agent being at least one by drocarbon-based block copolymer, said oily phase also comprising at least one hydrocarbon-based oil and particles of at least one polymer surface-stabilized with a stabilizer; said phases forming therein a macro scopically homogeneous mixture; and said composition also comprising at least one hydrocarbon-based resin with a number-average molecular weight of less than or equal to 10 000 g/mol; and pentylene glycol.

Abstract: Compositions of the invention contain, in a cosmetically acceptable aqueous medium, a) a cationic polyelectrolyte, b) at least one surfactant; and (c) from about 0.01 to about 1.2 weight percent of an anionic polyelectrolyte, where the weight ratio of the anionic polyelectrolyte to the cationic polyelectrolyte is from about 0.05 to about 1.2, and where the composition exhibits a viscosity change that is below a minimum significant-change-threshold (??min) and exhibits no measurable yield stress or increase in yield stress value when compared to a substantially identical composition that does not contain from about 0.01 to about 1.2 weight percent of the anionic polyelectrolyte, at a weight ratio of anionic polyelectrolyte to cationic polyelectrolyte of from about 0.05 to about 1.2.

Abstract: The present disclosure relates to methods comprise applying a skin-tightening composition to mask superficial scar tissues. Compositions comprise at least one thermoplastic elastomer, at least one adhesive polymer, and at least one filler.

Abstract: The invention relates to a strippable aqueous nail varnish composition containing an aqueous polyurethane dispersion as a film-forming agent, characterized in that it also comprises an aqueous anionic colloidal silica dispersion containing sodium or ammonium counter-ions, preferably containing silica particles measuring between 5 and 45 nm. The presence of said colloidal silica stabilizes the polyurethane dispersion, by preventing sedimentation, particularly when the varnish composition contains pearls or glitter dust.

Abstract: A cosmetic composition capable of forming a multilayer structure after application to a keratinous material, wherein the cosmetic composition comprises at least two immiscible components A and B, wherein the component A comprises at least one silicone and/or hydrocarbon-containing film-forming agent and wherein the component B comprises one or more silicone compounds.

Abstract: A method of treating the skin or hair on a dog containing an effective amount of an ectoparasiticide previously applied to the skin or hair, comprising applying a quantity of a cleansing composition directly to the skin or hair, wherein the treatment does not result in reducing the efficacy of the ectoparasiticide against adult fleas (C. felis) or adult ticks (R. sanguineus) below 90% efficacy for at least a month after application of the ectoparasiticide; wherein the cleansing composition comprises about 1-3% glycerin; about 2-4% silicone copolyol esters, water and is essentially free of surfactant.

Abstract: The disclosure relates to compositions, films, and methods for improving the appearance of the skin. Compositions comprise at least one thermoplastic elastomer, at least one adhesive polymer, and at least one filler. Methods comprise applying the compositions to the skin to tighten the skin or hide skin imperfections, by forming a film on the skin.

Abstract: A method of manufacturing a nicotine-containing mucoadhesive film, by preparing an aqueous solution at a pH of from 9.5 to 13, the solution includes (i) a nicotine salt, (ii) an alkaline pH-regulating agent, and (iii) a film-forming agent including an alginate salt of monovalent cation or a mixture of alginate salts of monovalent cations, the film-forming agent having a mean guluronate (G) content of from 50 to 85% by weight, a mean mannuronate (M) content of from 15 to 50% by weight, a mean molecular weight of from 30,000 g/mol to 90,000 g/mol and being such that a 10% aqueous solution thereof at a temperature of 20° C. has a viscosity of 100-1000 mPas, as measured at a shear rate of 20 rpm by use of a Brookfield viscometer with a spindle No. 2; distributing the solution onto a solid surface; and permitting the solution to dry on said surface. A nicotine-containing mucoadhesive film.

Abstract: The present invention relates to an inhalation gas composition comprising oxygen and a mixture of inert gases, characterized in that the mixture of inert gases comprises a first compound selected from xenon and argon having hyperthermal properties, and a second compound having hypothermal properties, the mixture of inert gases comprising such a proportion of the first and second compounds that the mixture of inert gases is thermally neutral.

Abstract: Human warts have been the subject of many treatment options. Most of the effective strategies involve invasive procedures or painful treatments. The goal of this treatment is to find a topical application of a compound that will remove the infected tissue without significant discomfort to the patient. The present invention effects the treatment by using a polymerizing compound that forms a boundary between the hyperkeratotic layer of infected epithelial cells and the healthy skin cells. This modality is both painless and does not harm healthy cells.

Abstract: Disclosed are PTHrP analogue formulations for transdermal delivery of a therapeutically effective amount of a PTHrP analogue, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract: Embodiments of the invention include devices, compositions and methods for the controlled release of therapeutic substances, such as drugs. Control over the rate of release of the therapeutic substances from the devices is achieved by the use of nanoporous membranes in which the pore size is matched to the molecular diameter of the therapeutic substances. Some embodiments of the invention achieve zero-order release by the use of membranes with a pore diameter that is more than five times the Stokes' diameter of the therapeutic substance released.

Abstract: Geometrically complex intravaginal rings, systems and methods of making the same are provided herein. Disclosed herein are geometrically complex intravaginal rings with tunable and enhanced drug release, which in some embodiments can be fabricated by 3D printing technologies. The disclosed IVRs include a ring structure comprising a plurality of unit cells or macroscopic and/or microscopic architecture, which can be tuned to control the loading capacity of an active compound within the IVR, the diffusion of an active compound from the IVR, the surface area of the IVR, and/or the mechanical properties of the IVR. The disclosed geometrically complex IVRs can provide superior control over drug loading and drug release compared to conventional IVRs fabricated by injection molding or hot-melt extrusion.

Abstract: The present invention relates to methods of treating blepharitis and dry eye by inhibiting the binding ability of lid flora bacteria such as Staphylococcus aureus and Staphylococcus epidermidis, thus inhibiting biofilm formation and the increase in bacterial populations and densities that lead to quorum-sensing-gene activation and therefore, the production of inflammatory virulence factors.

Abstract: Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as complex regional pain syndrome.

Abstract: A pet food product includes a food substrate manufactured by extrusion, baking or other process involving heat. The pet food product includes less than 10% of hemp oil by weight, and preferably less than 5% by weight. The hemp oil has cannabinoids, including acidiccannabinoids. The acidic cannabinoids have a concentration of less than 100 parts per million, and preferably between 10-40 parts per million in the hemp oil. The acidic cannabinoids include cannabidiolic acid (CBD-A) and cannabidiol (CBD) in a ratio of at least 1:1, and preferably 3:1, or greater. An antioxidant is added to the hemp oil to inhibit oxidation of the acidiccannabinoids including the (CBD-A). The pet food product includes a second oil blended with the hemp oil. The antioxidant and the second oil cooperate to inhibit oxidation of the acidic cannabinoids.

Abstract: A probiotic tablet comprising a probiotic micro-organism and other nutritionally active ingredients in two zones, a first zone comprising said probiotic micro-organism and precisely selenium, and a second zone comprising at least one said other active ingredient such as iron, other minerals and vitamin B6 kept separated from the probiotic micro-organism of said first zone, the water activity in said probiotic micro-organism containing first zone being no greater than 0.2 and the water content of said tablet being as much as 3% by weight. Good viability of the micro-organisms is obtained despite the relatively high overall moisture content.

Abstract: A controlled release dosage form containing monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof wherein the monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof is delivered to the subject. Also provided is a method of treating a disease or disorder (e.g., multiple sclerosis) by orally administering a controlled release dosage form containing monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof, wherein the monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof.

Abstract: Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N?-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved.

Abstract: A nanoemulsion containing a quaternary ammonium salt with at least a twenty carbon chain is effective to prevent the growth of biofilms.

Abstract: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g.

Abstract: Embodiments of the present disclosure include anti-inflammatory compositions and methods of use thereof. The compositions include purified lipids from Francisella, for example, virulent strains of Francisella. Other features and advantages of the invention will be apparent from the detailed description, and from the claims.

Abstract: Novel encapsulated umirolimus and umirolimus polymer conjugate formulations having enhanced permeability and retention at tumor sites. Also provided are methods for treating cancer by administering the umirolimus formulations.

Abstract: To provide a preparing method for a charged niosome which is formed of a lipid containing a diacylglycerol PEG adduct and which is capable of being excellently impregnated into the skin and stored in the skin.

Abstract: Provided herein are compositions and methods for diagnosis and treatment of early-stage atherosclerotic plaques and reduction of plaques in arteries. In particular, provided herein are high-density-lipoprotein-functionalized magnetic nanostructures (HDL-MNS) capable of (i) precise anatomic detection of atherosclerotic lesions, (ii) removal of excess cholesterol from macrophage cells in atherosclerotic plaque, and/or (iii) delivery of therapeutic agents to plaque locations, and methods of diagnosis and treatment of atherosclerosis.