Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.

Abstract: The present invention relates, in some embodiments thereof, to systems, devices and methods allowing for an engagement of two or more vessels or devices in a decontaminated manner. In some embodiments of the invention, the systems and devices of the invention include a first connection interface attached to a first vessel having a spring and/or valve mechanism and a second connection interface attached to a second vessel, wherein the first connection interface and the second connection interface are configured to allow for an engagement between the first vessel and the second vessel, and wherein the first and second connection interfaces are further configured to externally displace from the engagement between the first vessel and the second vessel while a hermetically sealed connection is maintained between the first vessel and the second vessel.

Abstract: Fluid transfer devices for filling a drug pump cartridge with liquid drug contents for administration purposes. Fluid transfer device includes a dual open ended barrel partitioned by a transverse partition into a drug vial port for telescopic mounting on a drug vial and an open ended piston cylinder for slidingly receiving a piston head including a drug pump cartridge port for telescopic mounting on a leading cartridge end of a drug pump cartridge. Sliding insertion of the piston head into the piston cylinder to butt against the transverse partition urges air trapped in the compression chamber into the drug vial which in turn urges its liquid drug contents into the vented drug pump cartridge.

Abstract: According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

Abstract: A syringe holding assembly for filling a syringe with medication includes a block that has a first well therein to insertably receive a medication bottle. The block has a second well therein to insertably receive a syringe. The first well is aligned with the second well to align the syringe with the medication bottle. In this way a user with limited hand dexterity is assisted to fill the syringe with medication. An adapter is provided to receive a vial. The adapter is removably positioned in the first well thereby facilitating the vial to be aligned with the syringe.

Abstract: Provided is a die roll for manufacturing softgels, a softgel, and methods for producing a softgel. The die roll includes a die roll surface and a pocket defined therein. The pocket includes a floor, an interior sidewall surface, a chamfer, and an exterior sidewall surface. The floor is recessed relative to the die roll surface and the interior sidewall surface is connected to the floor and extends above the die roll surface to the chamfer. The pocket also includes a landing surface that is elevated from the die role surface and connects the chamfer to the exterior sidewall surface of the pocket. The landing surface includes a taper (such that the landing surface tapers inwardly towards the pocket floor) and a radius (such that the landing surface is not flat). Also provided is a softgel having a trailing edge thickness that is at least about 40% the thickness of the softgel wall thickness.

Abstract: A baby feeding bottle (1) comprising a cavity (2) adapted to hold a fluid; and a nipple (3) having an opening (4), the nipple (3) is coupled to the cavity, so as to allow the fluid to pass through the opening (4) of the nipple (3), wherein the nipple (3) further comprises a tube (5) which is placed within the nipple (3), and a sealed end (6) of the tube (5) is coupled to the opening of the nipple, and a free end (7) opposite to the sealed end (6) is having a flexible closure (8) adapted to be in an open position to allow the flow of the fluid on application of force onto an outer surface of the nipple (3), and to be in a closed position to disallow the flow of the fluid on removing the force onto the outer surface of the nipple (3). Embodiments including an assembly of the feeding bottle and method for using the feeding bottle is are also presented.

Abstract: Provided herein is an enteral safe feeding catheter that allows for a higher rate of delivering liquid food and/or drugs to the stomach and/or duodenum of a mammal while simultaneously allowing for aspiration of any regurgitated reflux escaping the stomach into the esophagus. Systems incorporating the catheter and methods of use thereof are also provided herein.

Abstract: A system and method for fitting pacifiers and other implements to a particular child. One or more images of the child are used to determine anthropometric data that can be used to properly size a pacifier bulb and properly fit other implements.

Abstract: A method of making a monolithic dental restoration. The method includes the steps of providing a monolithic precursor of a dental restoration and firing the monolithic dental restoration precursor to provide the monolithic dental restoration. The zirconia material of both the dental restoration precursor as well as the dental restoration has a relative density of greater than 98% of the theoretic density of the zirconia material. The invention helps providing a color of a non-glazed dental restoration which resembles the color of a glazed dental restoration.

Abstract: Dental composition comprising (a) a homogeneous phase comprising monomer combinations (i) and (ii), (i) and (iii), (ii) and (iii), or (i), (ii) and (iii), or comprising monomer (iii), wherein (i) represents one or more compounds having one or more radically polymerizable carbon-carbon double bonds; (ii) represents one or more compounds having one or more cationically polymerizable groups; and (iii) represents one or more compounds having a combination of one or more radically polymerizable carbon-carbon double bonds and one or more cationically polymerizable groups; (b) an initiator system comprising (iv) one or more radical polymerization initiator of the following formula (I): wherein M is Ge or Si; R1, R2 and R3 may be the same or different, independently represent an organic group, and R4 represents a hydrogen atom, an organic or organometallic group; provided that when R4 is a hydrogen atom, the initiator system further comprises a sensitizer compound having a light absorption maximum in the rang

Abstract: Disclosed here in is a dental composition having a novel polymerizable compound, a photosensitizer and an iodonium salt. Further disclosed are method of preparing a dental composition.

Abstract: Provided is a polyether-based urethane foam for impregnating a cosmetic composition. The polyether-based urethane foam has excellent touch feel, portability and stability.

Abstract: The invention provides a personal cleansing composition having an aqueous continuous phase including cleansing surfactant and a solubilised hydrocarbon oil having a kinematic viscosity of 1 to 35 cSt at 40° C. and a specific gravity of 0.76 to 0.87 at 25° C.; in which the hydrocarbon oil is solubilised in wormlike micelles in the aqueous continuous phase by means of a linker molecule and an inorganic electrolyte; in which the linker molecule is selected from one or more compounds of formula: R(X)n, in which R is a C6 to C14 mono-, di- or trivalent saturated aliphatic or an aromatic hydrocarbyl group, n is 1 to 3 and each X is independently selected from —OH and —COOH; and in which the level of hydrocarbon oil in the composition ranges from 0.8 to 1.5% by weight based on the total weight of the composition.

Abstract: The present invention relates to a cosmetic composition for concealing wrinkles. The cosmetic composition according to the present invention causes diffuse reflection of light on a wrinkled spot without using powder and effectively fills the wrinkled spot of skin, thereby enabling a temporary concealing of the wrinkle. Because powder is not used, the cosmetic composition has an excellent feeling of use when applied to the skin and prolonged adhesion to the skin, with no white turbidity.

Abstract: The present invention relates to personal cleansing compositions in ‘post-foaming’ gel or cream form, which are particularly mild, can contain high levels of emollient skin-care ingredients and produce copious amounts of creamy foam in use. The structure of the compositions enables stable post-foaming gels or creams to be made combining unusually low surfactant levels with high levels of emollient oils. The present invention provides an effective solution to the dual consumer need for highly skin caring cleansing formulations with excellent foaming characteristics.

Abstract: The present invention relates to a self-foaming or post-foaming gel or cream composition, comprising surface active agents and polymer, plus a post-foaming agent packaged in an aerosol or other container. The composition is milder than a typical soap based system, and delivers acceptable performance at a cost below that of equivalently performing systems based upon synthetic surfactants.

Abstract: The invention provides liquid cleansing composition comprising having mild surfactant, specifically salts of N-acyl polycarboxylic acid where pH of composition is preferably 6.5 and below. By combining with particular defibrillated cell wall materials, the mild surfactants can be structured and also have surprisingly good foam stability.

Abstract: A composition comprises a fragrance and/or oil and a surfactant, wherein the composition is free of lower alkyl alcohols and wherein the composition is a nanoemulsion.

Abstract: A water-in-oil type emulsified cosmetic has an unprecedented property wherein, by coming into contact with perspiration or water, the color development and the color uniformity are improved over the conditions immediately after application. The water-in-oil type emulsified cosmetic includes: (A) an organically modified clay mineral; (B) an oil phase thickener other than the (A) organically modified clay mineral; (C) a non-volatile liquid oil other than a silicone oil; (D) a silicone-based surfactant having an HLB of less than 8; and (E) a colorant; wherein a weight ratio defined by [(A)+(B)]/(C) is at least 0.04 and less than 0.68.

Abstract: Oral care compositions comprising an antifibrinolytic agent (e.g., tranexamic acid) and stannous ion source are provided for promoting Gum Health of a consumer.

Abstract: The present invention provides a sunscreen composition comprising cerium oxide (CeO2) particles that are surface-modified with silicone, wherein the silicone is methicone, a methicone derivative, or an alkyl silane. The sunscreen composition according to an embodiment of the present invention is easy to be prepared into a formulation applicable to cosmetics and may have a high physical ultraviolet protection effect to block ultraviolet rays in a wide range of wavelengths with an excellent sun protection factor (SPF). In addition, the sunscreen composition according to an embodiment of the present invention has a skin-like color in view of the color tone of the composition and does not cause white cast even when applied to the skin, and thus the composition can be effectively used in producing cosmetics for UV protection that aim to express natural color.

Abstract: The present specification discloses a composition comprising, consisting essentially of, or consisting of one or more grip enhancers, one or more hydrophilic clays, and/or one or more polysaccharides, kits comprising, consisting essentially of, or consisting of a disclosed composition, methods and uses to improve the grip capacity of an individual by applying a disclosed composition, and methods and uses to improve the grip capacity of an object by applying a disclosed composition.

Abstract: The present invention provides an aqueous oral rinse composition which includes zinc chloride, sorbitol, one or more pyrophosphates, and water. Methods of providing such an oral rinse composition are also provided herein.

Abstract: The invention provides a zinc-lysine complex having the formula [Zn(C6H14N2O2)2Cl]+Cl? having antibacterial and antiperspirant properties, together with personal care compositions comprising the complex, and methods of making and using these complexes and compositions.

Abstract: A packaged aerosol foaming skin cleanser can include a multiphase skin cleansing composition; a foaming agent including a hydrofluoroolefin, a hydrochlorofluoroolefin, or a combination thereof; and a package.

Abstract: The present invention relates to an antimicrobial composition and more particularly an antimicrobial composition for leave-on applications. The present invention discloses an antimicrobial composition comprising; a) 0.01 to 2% by weight of thymol; b) 0.01 to 2% by weight of terpineol; and c) 0.1 to 2% by weight of a cationic phospholipid complex.

Abstract: The present invention relates to topical compositions comprising 10-hydroxystearic acid or a salt thereof in combination with 12-hydroxystearic acid or a salt thereof. The present invention also relates to a method to retard or inhibit the recrystallisation of 10-hydroxystearic acid or a salt thereof in a topical composition, said method comprising formulating 10-hydroxystearic acid or a salt thereof in the presence of 12-hydroxystearic acid or a salt thereof.

Abstract: The present invention relates to a composition for dyeing keratin fibres, in particular keratin fibres such as the hair, comprising: a) at least one oxidation base 3-(2,5-diaminophenyl)-1-propanol acid salts thereof or solvates thereof such as hydrates; b) at least one heterocyclic oxidation base; c) at least one coupler; d) optionally at least one fatty substance; e) optionally at least one basifying agent; and f) optionally at least one chemical oxidizing agent. The invention also relates to a process for dyeing keratin fibres such as the hair using the composition of the invention, and to a multi-compartment device for using the composition of the invention.

Abstract: The present invention refers to a hair dye comprising a) an alkalinising agent consisting of at least one amino acid having a pKa of greater than 10.00 and at least one ester of a fatty acid and glycerol polyethoxylate; and b) at least one oxidation colourant. In particular, the composition of the invention does not comprise any further alkalinizing agent. Kits and methods for colouring hair based on this composition also fall within the scope of this invention.

Abstract: An oral care composition comprising zinc phosphate, stannous fluoride, arginine or lysine and an organic acid buffer system, as well as methods of using the same.

Abstract: The invention relates to a hair care composition comprising: from about 23 weight % to about 45 weight % total surfactant; from about 15 weight % to about 45 weight % anionic surfactant; from about 1 wt % to about 4.75 wt % soluble salt, and an aqueous carrier, wherein the hair care composition has a viscosity of less than 8,000 cP at 26.5° C. The hair care composition can be dispensed as a foam.

Abstract: The invention relates to a aerosol compact hair care composition comprising: from about 23 weight % to about 45 weight % total surfactant; from about 15 weight % to about 40 weight % anionic surfactant; less than about 12 wt % of zwitterionic surfactant; from about 0.5 wt % to about 50 wt % of a viscosity reducing agent selected from the group consisting of a water-miscible solvent, hydrotrope and mixtures thereof; from about 3 wt % to about 15 wt % hydrocarbon foaming agent; wherein the ratio of zwitterionic surfactant to viscosity reducing agent is less than about 1.5.

Abstract: The invention relates to a aerosol compact hair care composition comprising: from about 23 weight % to about 45 weight % total surfactant; from about 15 weight % to about 40 weight % anionic surfactant; less than about 0.5 wt % of zwitterionic surfactant; from about 0.5 wt % to about 6 wt % of a material selected from the group consisting of a water-miscible solvent, hydrotrope and mixtures thereof; from about 3 wt % to about 15 wt % hydrocarbon foaming agent; wherein the ratio of zwitterionic surfactant to water-miscible solvent or hydrotrope is less than about 2.

Abstract: A packaged aerosol foaming skin cleanser can include a multiphase skin cleansing composition, a low pressure foaming agent, and a package.

Abstract: The present invention belongs to the fields of pharmaceuticals and cosmetics, and concerns on the one hand a medicament for the inhibition of and refers also on the cosmetic, non-therapeutic use for the treatment of hyperpigmentation, particularly induced by sun light radiation, preferably induced by visible light radiation.

Abstract: The invention provides a cosmetic composition for skin and/or hair care comprising one or more ?-aspartyl dipeptides, or oligomers thereof, or salts thereof, wherein each of said ?-aspartyl dipeptides comprises a ?-L-aspartyl moiety as the first amino acid residue. The invention further relates to a method for human skin and/or hair care, including anti-aging and/or anti-hair loss utilizing this composition.

Abstract: The instant disclosure relates to methods and kits for artificially coloring hair and improving the durability of the artificially colored hair. The methods include: (I) combining an antioxidant booster composition, a hair coloring base composition, and a developer composition to form an antioxidant-enriched hair coloring composition within 2 hours of application to the hair; (II) applying the antioxidant enriched hair coloring composition to the hair and allowing the antioxidant enriched hair coloring composition to remain on the hair for a period of time; and (III) rinsing the antioxidant enriched hair coloring composition from the hair. The antioxidant booster composition can be included in a kit with a hair coloring base composition and/or a developer composition, wherein the antioxidant booster composition, the coloring base composition, and the developer composition are separately contained.

Abstract: Method for treating hair comprising the successive application onto hair of polymeric layers which can be removed to a large extent or even totally in an easy manner upon request of the user by using a composition having a pH less than 7.

Abstract: The invention relates to a cosmetic composition comprising: (a) at least 2% by weight, relative to the total weight of the composition, of one or more compounds chosen from urea and/or urea derivatives, (b) one or more polymeric thickeners chosen from nonionic, cationic, amphoteric polymeric associative thickeners or anionic polymeric associative thickeners comprising one or more acrylic and/or methacrylic units. The invention also relates to the use of this composition for straightening keratin fibres. Finally the invention relates to a process for straightening keratin fibres.

Abstract: Aqueous emulsions containing a high proportion of aminoalkyl-functional organopolysiloxane and a lesser proportion of emulsifying surfactant are stable and clear when the emulsifying surfactant comprises an ethoxylated linear alcohol having 10 carbon atoms or less.

Abstract: A method for at least one of whitening skin, improving skin condition, protecting skin, and treating skin disease is provided, wherein the method comprises administering to a subject in need an effective amount of a Pyrenaria buisanensis extract. A method for at least one of preventing cardiovascular disease, treating cardiovascular disease, preventing diabetes, treating diabetes, preventing neurodegenerative disease, and treating neurodegenerative disease is also provided, wherein the method comprises administering to a subject in need an effective amount of a Pyrenaria buisanensis extract.

Abstract: The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone, paliperidone or a combination thereof, as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved from the first day up to at least 14 days or more even up to at least four weeks.

Abstract: The present invention relates to a sublingual composition comprising a part of branch extract, preferably from at least one resinous tree comprising at least about 50% by weight of polyphenols and less than about 10% by weight of terpenes, relative to the total weight of the extract. The present invention further relates to the non-therapeutic uses of such sublingual composition for improving the respiratory wellness, relieving joint pain and/or muscular pain and cramps and/or improving endurance, and improving libido and/or fertility.

Abstract: Formulation comprising buprenorphine or a pharmaceutically acceptable salt thereof as the sole active ingredient, a viscosity enhancer, and a buffering agent in an amount to provide a pH of from 5.0 to 7.0 are useful for treating opioid withdrawal syndrome.

Abstract: The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.

Abstract: Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.

Abstract: The present invention relates to a composition for treating inflammation and/or promoting wound healing comprising macadamia oil, beeswax and shea butter as the major active components. The composition has efficacy in the treatment of a range of skin conditions.

Abstract: A method of treating a patient in need of therapy with fentanyl or a salt thereof, the method comprising providing a ready-to-administer solution consisting essentially of fentanyl or a salt thereof as the sole active ingredient, a sugar or sugar alcohol and water for injection, the solution having a pH in the range of 3.5 to 7.5, and parenterally administering the solution to the patient.

Abstract: The present invention relates to a self-assembled nanoparticle releasing microneedle structure which is formed of biocompatible amphiphilic block copolymers containing a drug, and a preparation method therefor. The microneedle structure according to the present invention can deliver a water-soluble or hydrophobic drug while being carried in a microneedle. In particular, since a fat-soluble drug is delivered while being carried by micelle-type self-assembled nanoparticles which are formed as the structure is dissolved, it is possible to greatly increase the solubility in an aqueous solution. As such, existing drugs with poor absorption can be delivered through the skin of a body.