Patents Issued in April 30, 2019
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Patent number: 10273173Abstract: A plant and method for controlling such a plant suitable for treatment of waste water. The plant includes a basin, a flow generating machine adapted to generate a liquid flow in the basin, equipment in the basin that effects the momentum of the liquid flow, and a control unit. The method includes the steps of: storing a predetermined relationship between the operational speed N of the flow generating machine and an operational parameter P from which the torque M of the flow generating machine may be derived, determining the operational speed N, determining a set value of the operational parameter P of the flow generating machine, determining a real value of the operational parameter P of the flow generating machine, and adjusting the operational speed N if the real value of the operational parameter P is different than the set value of the operational parameter P.Type: GrantFiled: June 15, 2015Date of Patent: April 30, 2019Assignee: XYLEM IP MANAGEMENT S.À R.L.Inventor: Lars Uby
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Patent number: 10273174Abstract: A device for treating wastewater liquids, the device comprising a housing (4) incorporating a membrane supported biofilm reactor (MSBR) (2) of the type comprising a lumen containing a gas phase, a liquid phase, and a gas permeable membrane (20) providing an interface between the gas and liquid phases; and a means (6) for mixing the wastewater liquids in the device, wherein the means (6) for mixing the wastewater liquids is configured to create a mixing intensity sufficient to ensure that there is contact between the membrane (20) and the wastewater liquid to be treated.Type: GrantFiled: March 4, 2015Date of Patent: April 30, 2019Assignee: Oxymem LimitedInventors: Eoin Syron, Wayne Byrne
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Patent number: 10273175Abstract: A septic system, including a septic tank and a pipe positioned within the septic tank, is provided. The pipe receives sewage and provides a flooded, anaerobic environment for sewage passing therethrough. The outlet of the pipe is positioned inside the septic tank and is optionally spaced from the outlet of the septic tank. In operation, the sewage introduced into the pipe generally separates into a solid portion comprising sludge, which remains in the pipe, and a liquid portion, which passes through and around the sludge. In one embodiment, the septic system has an absence of a sump chamber upstream of the septic tank.Type: GrantFiled: April 12, 2017Date of Patent: April 30, 2019Assignee: Waterloo Biofilter Systems Inc.Inventor: Edwin Craig Jowett
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Patent number: 10273176Abstract: The present invention relates to partial decarboxylation of polyitaconic acid polymers or copolymers. The partially decarboxylated resins are suitable for use in preparation of dispersions as well as for anti-scaling applications.Type: GrantFiled: October 4, 2016Date of Patent: April 30, 2019Assignee: Itaconix CorporationInventors: Yvon Durant, Brian Luthi, John Shaw
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Patent number: 10273177Abstract: An apparatus to lift liquid from a reservoir of liquid and aerate the liquid. A downwardly opening enclosure has an inlet for liquid to flow from a reservoir into the enclosure. The enclosure includes a channel for the liquid to flow upward. An inner cone within an outer cone forms a gas chamber connected to an external gas compressor. Holes in the gas chamber walls allow the gas to flow into the channel and aerate the liquid which is returned to the reservoir.Type: GrantFiled: October 4, 2017Date of Patent: April 30, 2019Inventor: John T. Vlahogeorge
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Patent number: 10273178Abstract: A glassmelting furnace is provided in which the burners are elevated above the glassmelt surface and are oriented at an angle upwards relative to the glassmelt surface.Type: GrantFiled: December 16, 2015Date of Patent: April 30, 2019Assignee: PRAXAIR TECHNOLOGY, INC.Inventors: Osemwengie Uyi Iyoha, Hisashi Kobayashi, Euan J. Evenson
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Patent number: 10273179Abstract: A glass manufacturing system and method are described herein for forming a high quality thin glass sheet. In one embodiment, the glass manufacturing system and method use at least one of a compensated rolling roll, a temperature controlled environment and edge rolls to form a high quality thin glass sheet that has a thickness less than about 2 mm and more preferably less than about 100 ?m.Type: GrantFiled: June 4, 2014Date of Patent: April 30, 2019Assignee: Corning IncorporatedInventor: Allan Mark Fredholm
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Patent number: 10273180Abstract: A cartridge assembly includes a hub portion having a first end and a second end, a first retaining ring portion including a first snap ring and a first retaining ring member, and a second retaining ring portion including a second snap ring and a second retaining ring member. The cartridge assembly further includes a plurality of disc elements positioned between the first retaining ring portion and the second retaining ring portion, where the plurality of disc elements has an outer diameter that is greater than an outer diameter of the first retaining ring portion and the second retaining ring portion, and a plurality of fastening members positioned at the first end and the second end of the hub portion, the plurality of fastening members extending radially inward from the hub portion.Type: GrantFiled: May 5, 2017Date of Patent: April 30, 2019Assignee: Corning IncorporatedInventors: Ralph Alfred Langensiepen, Brandon Thomas Sternquist, Lewis Kirk Klingensmith, Eric Joseph Teator, Izhar Zahoor Ahmed, Do-hun Lee
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Patent number: 10273181Abstract: A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.Type: GrantFiled: November 21, 2017Date of Patent: April 30, 2019Assignee: Mosci, Corp.Inventor: Steven Jung
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Patent number: 10273182Abstract: An apparatus, method, and process that includes a substantially transparent substrate having a first surface, a second surface, and an edge extending around at least a portion of a perimeter of the substantially transparent substrate, wherein the edge is a laser induced channel edge having enhanced edge characteristics.Type: GrantFiled: August 21, 2014Date of Patent: April 30, 2019Assignee: GENTEX CORPORATIONInventors: Donald L. Bareman, William L. Tonar, Niels A. Olesen, Thomas J. Scott, David J. Cammenga, Henry A. Luten, George A. Neuman
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Patent number: 10273183Abstract: A soda-lime-silica glass-ceramic article having an amorphous matrix phase and a crystalline phase is disclosed along with a method of manufacturing a soda-lime-silica glass-ceramic article from a parent glass composition comprising 47-63 mol % SiO2, 15-22 mol % Na2O, and 18-36 mol % CaO. The crystalline phase of the glass-ceramic article has a higher concentration of sodium (Na) than that of the amorphous matrix phase.Type: GrantFiled: July 14, 2017Date of Patent: April 30, 2019Assignee: Owens-Brockway Glass Container Inc.Inventors: Scott P Cooper, Samuel Schuver, Carol A Click
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Patent number: 10273184Abstract: A method of performing ion exchange of a thin, flexible glass substrate having an average thickness equal to or less than about 0.3 mm to chemically strengthen the glass substrate is disclosed. The chemically strengthened glass substrate comprises a first compressive stress layer having a first depth of layer, and a second compressive stress layer having a second depth of layer, the first and second stress layers being separated by a layer of tensile stress. A laminated article comprising the chemically strengthened glass substrate is also described.Type: GrantFiled: October 13, 2014Date of Patent: April 30, 2019Assignee: Corning IncorporatedInventors: Sean Matthew Garner, Michael Lesley Sorensen
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Patent number: 10273185Abstract: A repair compound for use in all applications and particularly well-suited for large hole repair. The repair compound includes a latex resin, a thickener, fibers, and a filler material. In some embodiments, the repair compound is configured to exhibit pseudoplastic-type behavior. In some embodiments, the repair compound has a density of not greater than 4.0 lbs/gal. In some embodiments, the repair compound includes hydrophobic and hydrophilic fibers of different morphologies. In some embodiments, the repair compound includes HASE-type thickeners. In some embodiments, the repair compound includes a bimodal distribution of hollow glass microspheres from two different strength/size curves.Type: GrantFiled: June 10, 2015Date of Patent: April 30, 2019Assignee: 3M Innovative Properties CompanyInventors: John E. Gozum, DanLi Wang, Dwight B. Schoenherr
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Patent number: 10273186Abstract: A reactive resin composition is described, with a resin component, which contains a radical-polymerizable compound, and an initiator system, which contains an ?-halocarboxylic acid and a catalyst system, which comprises a nitrogen-containing ligand and Cu(0) or an inorganic Cu(I) compound, as is the use of the same for construction purposes.Type: GrantFiled: December 18, 2015Date of Patent: April 30, 2019Assignee: Hilti AktiengesellschaftInventor: Armin Pfeil
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Patent number: 10273187Abstract: A process for making a cement, the cement containing a naturally occurring silicate bound in an organic binder, and a metal oxide. An example process includes dissolving the organic binder at least in part, using an effective amount of a chemical activator. An example process also includes providing the silicate to react with other components of the cement. An example process also includes providing the silicate to participate in crystal growth. An example process also includes providing the silicate so that the cement is a structural load bearing cement.Type: GrantFiled: December 18, 2017Date of Patent: April 30, 2019Inventor: Trevor Cyril Waters
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Patent number: 10273188Abstract: The invention relates to a pulverulent composition which can be produced by bringing a powder which comprises at least one inorganic binder into contact with from 0.01 to 10% by weight, based on the total mass of the composition, of a liquid component comprising at least one copolymer which can be obtained by polymerization of a mixture of monomers comprising (I) at least one ethylenically unsaturated monomer which comprises at least one radical selected from the group consisting of carboxylic acid, carboxylic acid salt, carboxylic esters, carboxamide, carboxylic anhydride and carboximide and (II) at least one ethylenically unsaturated monomer having a polyalkylene oxide radical, where the liquid component contains at least 1% by weight of the at least one copolymer and at least 30% by weight of an organic solvent. Furthermore, a process for producing the liquid component, the use thereof and also specific copolymers are disclosed.Type: GrantFiled: September 25, 2012Date of Patent: April 30, 2019Assignee: BASF Construction Solutions GmbHInventors: Manfred Bichler, Michael Schinabeck, Norbert Steidl, Werner Strauss, Markus Maier, Markus Wilde
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Patent number: 10273189Abstract: A zirconia sintered body that suppresses discoloration due to porcelain. The zirconia sintered body contains at least one of a coloring agent A, which is erbium oxide and a coloring agent B, which is nickel oxide, and contains a composite oxide of zirconium and vanadium. A composition, containing zirconium oxide, yttrium oxide, and a coloring agent, where the coloring agent contains at least one of a coloring agent A, which is erbium oxide and a coloring agent B, which is nickel oxide, and contains a coloring agent C, which is a composite oxide of zirconium and vanadium.Type: GrantFiled: October 30, 2015Date of Patent: April 30, 2019Assignee: KURARAY NORITAKE DENTAL INC.Inventors: Yoshihisa Ito, Atsushi Matsumoto, Tomohiro Emoto
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Patent number: 10273190Abstract: The present invention provides a focus ring having favorable plasma resistance. In addition, the present invention provides a method for producing a focus ring which enables the easy production of focus rings having favorable plasma resistance. The focus ring of the present invention is a focus ring made of a sintered body of silicon carbide, in which the sintered body includes a plurality of first crystal grains having an ?-SiC-type crystal structure and a plurality of second crystal grains having a ?-SiC-type crystal structure, a content of the first crystal grains is 70% by volume or more of a total of the first crystal grains and the second crystal grains, and a volume-average crystallite diameter of the first crystal grains is 10 ?m or less.Type: GrantFiled: August 23, 2016Date of Patent: April 30, 2019Assignee: SUMITOMO OSAKA CEMENT CO., LTD.Inventor: Hiroaki Nagatomo
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Patent number: 10273191Abstract: Provided is a zirconia sintered body having both high translucency and high strength. The zirconia sintered body includes crystal grains that include a cubic domain and a tetragonal domain, wherein a stabilizer and lanthanum is dissolved as a solid solution therein. The sintered body can be obtained by a manufacturing method including: a mixing step of obtaining a mixed powder by mixing a zirconia source, a stabilizer source, and a lanthanum source; a molding step of obtaining a green body by molding the obtained mixed powder; a sintering step of obtaining a sintered body by sintering the obtained green body at a sintering temperature of 1650° C. or higher; and a temperature lowering step of lowering the temperature from the sintering temperature to 1000° C. at a temperature lowering rate exceeding 1° C./min.Type: GrantFiled: January 12, 2016Date of Patent: April 30, 2019Assignee: TOSOH CORPORATIONInventors: Isao Yamashita, Yuya Machida
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Patent number: 10273192Abstract: A ceramic article includes a flexible backing selected from paper, woven fabric, non-woven fabric, polymeric films, metal foils, and combinations thereof. A green ceramic layer is on a first side of the flexible backing, wherein the green ceramic layer includes a ceramic material and a polymeric binder. A major surface of the green ceramic layer includes a pattern of features.Type: GrantFiled: February 17, 2016Date of Patent: April 30, 2019Assignee: Rolls-Royce CorporationInventors: Benjamin John Bowin Lai, Kang N. Lee, David J. Thomas
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Patent number: 10273193Abstract: A horticulture growth medium includes a base organic soil, a soft rock phosphate component, a limestone component, a hydrated magnesium sulfate salt, volcanic dust comprising trace mineral nutrients, one or more humic acids, a shell source of calcium, a bone or blood meal component selected from fish bone meal, blood meal, steamed bone meal, and/or combinations thereof, bat guano, and worm castings. A method of growing a plant using the horticulture growth medium of includes planting a plant with the horticulture growth medium and providing periodic water to the plant, the horticulture growth medium being sufficient for plant growth during a complete cycle without the use of additional fertilizing agents. A kit includes the horticulture growth medium along with instructions for using the horticulture growth medium to grow plants.Type: GrantFiled: September 29, 2015Date of Patent: April 30, 2019Inventor: Evan James Schick
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Patent number: 10273194Abstract: Disclosed are compositions and methods of making a liquid fertilizer additive of biodegradable polymers and/or oligomers comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more groups that react with the aldehyde(s) wherein said reactive groups are selected from the group consisting of a) primary and secondary amines, b) amides, c) thiols, d) hydroxyls and e) phenol.Type: GrantFiled: December 26, 2017Date of Patent: April 30, 2019Inventors: Gary David McKnight, Randall Linwood Rayburn, Wei Xu
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Patent number: 10273195Abstract: A method for the production of an agent for enhancing soil growth is described, comprising: grinding a biomass feedstock to produce ground biomass particles; subjecting the ground biomass particles to a biofractioning process including an auger reactor; selectively collecting at least one volatile component as it is released from the ground biomass particles; collecting a last remaining nonvolatile component comprising BMF char; rendering a surface of the BMF char hydrophilic; exposing the BMF char to microorganisms; and adding the BMF char to soil.Type: GrantFiled: November 10, 2016Date of Patent: April 30, 2019Assignee: Cool Planet Energy Systems, Inc.Inventors: Michael C. Cheiky, Ronald A. Sills
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Patent number: 10273196Abstract: The invention relates to hydrocarbon dehydrocyclization to produce products such as aromatic hydrocarbon, to equipment and materials useful for dehydrocyclization, to processes for carrying out dehydrocyclization, and to the use of dehydrocyclization for, e.g., natural gas upgrading. The dehydrocyclization is carried out in a catalytic reaction zone of a reverse-flow reactor.Type: GrantFiled: August 18, 2016Date of Patent: April 30, 2019Assignee: ExxonMobil Chemical Patents Inc.Inventors: Paul F. Keusenkothen, John S. Buchanan, John S. Coleman, Seth M. Washburn
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Patent number: 10273197Abstract: A method for producing high-purity terephthalic acid, comprising following steps (a) to (c): the step (a); obtaining crude terephthalic acid crystal by liquid phase-oxidizing a p-phenylene compound; the step (b); obtaining a terephthalic acid crystal slurry by a catalytic hydrogenation treatment of the crude terephthalic acid crystal; and the step (c); introducing the terephthalic acid crystal slurry into an upper portion of a mother liquor replacement tower, and bringing the slurry into contact with an upward flow of replacement water introduced from a bottom portion of the mother liquor replacement tower while making the terephthalic acid crystal settled down in the tower, and extracting the terephthalic acid crystal as a slurry with the replacement water from the tower bottom portion, wherein (1) a stirring blade unit is disposed in a slurry layer in the bottom portion of the mother liquor replacement tower, and fluidity of the slurry layer is maintained by rotating the stirring blade unit in such a wayType: GrantFiled: July 21, 2016Date of Patent: April 30, 2019Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Goh Nakamura, Hideaki Fujita, Kotaro Murakami
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Patent number: 10273198Abstract: A solvent exchanger and a method is provided for: pressurizing a CTA slurry into a solvent exchanger for separation and obtaining a mother liquor, a bias flow mother liquor and a suspended matter A; washing the suspended matter A to obtain a primary filtrate, a bias flow primary filtrate and a suspended matter B; washing the suspended matter B to obtain a secondary filtrate, a bias flow secondary filtrate and a suspended matter C; washing the suspended matter C to obtain a tertiary filtrate, a bias flow tertiary filtrate and a suspended matter D; washing the suspended matter D to obtain a fourth filtrate, a bias flow fourth filtrate and a suspended matter E; washing the suspended matter E to obtain a fifth filtrate, a bias flow fifth filtrate and a filter cake; and after finished, back-flushing the filter cake and then pulping to obtain a slurry, and discharging.Type: GrantFiled: January 9, 2015Date of Patent: April 30, 2019Assignee: TIANHUA INSTITUTE OF CHEMICAL MACHINERY AND AUTOMATION CO., LTDInventors: Xu Zhao, Wanyao Zhang, Zhongxin Sun, Yongpeng Tan, Xiangnan Zhai, Tianbao Wang, Yuanyue Liang, Guohai Zhang, Xiaopeng Feng, Yanshun Shen
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Patent number: 10273199Abstract: The invention relates to an hydrolysis vessel (200) used during amidification step of acetone cyanohydrin (ACH), in the industrial process for production of a methyl methacrylate (MMA) or methacrylic acid (MAA). The hydrolysis vessel (200) is used for hydrolyzing acetone cyanohydrine with sulfuric acid to produce a mixture comprising ?-sulfatoisobutyramide (SIBAM). It comprises at least one cooling system (212; 244) on its internal annular periphery area and it is divided into at least two stages, preferably three, along its vertical wall, each stage (S1 to S3) comprising a ACH feeding inlet (201, 202, 203). Such vessel allows controlling both homogeneity and temperature of the mixture, and thus obtaining a high yield for the hydrolyzing reaction in very safe conditions.Type: GrantFiled: October 17, 2014Date of Patent: April 30, 2019Assignee: Arkema FranceInventors: Yves Bernardin, Romain Billon, Xavier Marcarian, Florent Vallet
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Patent number: 10273200Abstract: Disclosed is a practical method for production of 3,3-difluoro-2-hydroxypropionic acid, which is important as pharmaceutical and agrichemical intermediates. The method includes forming a 4,4-difluoro-2,2-dichloro-3-oxobutanoic acid ester by reaction of a 4,4-difluoro-3-oxobutanoic acid ester with chlorine (Cl2), forming 3,3-difluoro-1,1-dichloro-2-propanone by reaction of the chlorination product with an acid, and then, reacting the degradation product with a basic aqueous solution.Type: GrantFiled: March 15, 2016Date of Patent: April 30, 2019Assignee: Central Glass Company, LimitedInventors: Takako Yamazaki, Ryuichi Okamoto, Akihiro Ishii
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Patent number: 10273201Abstract: The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the methacrolein obtained in step A) in an oxidative esterification reaction to give methyl methacrylate, characterized in that the two steps A) and B) take place in a liquid phase at a pressure of from 2 to 100 bar, and step B) is carried out in the presence of a heterogeneous noble-metal-containing catalyst comprising metals and/or comprising metal oxides.Type: GrantFiled: October 27, 2017Date of Patent: April 30, 2019Assignee: EVONIK RÖHM GmbHInventors: Steffen Krill, Torsten Balduf, Martin Koestner, Matthias Groemping, Alexander Lygin, Rudolf Burghardt
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Patent number: 10273202Abstract: Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.Type: GrantFiled: September 22, 2014Date of Patent: April 30, 2019Assignee: The Johns Hopkins UniversityInventors: John P. Toscano, Christopher M. Pavlos, Preeya Kapur Boppana
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Patent number: 10273203Abstract: The present invention relates to purified compounds of 3-methanesulfonylpropionitrile, in which at least one of the hydrogen, oxygen, sulfur, and nitrogen atoms is substituted with a respective isotope that includes, but not limited to 2H (deuterium), 3H (tritium), 13C, 14C, 15N, 17O, 18O, and 35S. The purified compound has at least 90% purity. Preferred compounds are deuterated 3-methanesulfonylpropionitriles.Type: GrantFiled: April 4, 2018Date of Patent: April 30, 2019Assignee: Olatec Therapeutics LLCInventors: Gerald S. Jones, Scott A. Goodrich, Joseph P. St. Laurent
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Patent number: 10273204Abstract: Disclosed herein are systems and processes involving the catalyzed cleavage reaction of dimethyl sulfide to methyl mercaptan. The catalyzed cleavage reaction can be a standalone system or process, or can be integrated with a methyl mercaptan production plant.Type: GrantFiled: August 19, 2016Date of Patent: April 30, 2019Assignee: Chevron Phillips Chemical Company LPInventors: Reza Khankal, Henry Hwu, Daniel M. Hasenberg, Christina M. Barry, Mitchell D. Refvik, Michael S. Hankinson
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Patent number: 10273205Abstract: The present invention relates to methods, formulations, and compositions for the treatment of biofilms. In particular, the application discloses isothiocyanate functional surfactants either alone or combination with adjunct agents to treat biofilms.Type: GrantFiled: October 18, 2017Date of Patent: April 30, 2019Assignee: The William M. Yarbrough FoundationInventor: Michael E. Silver
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Patent number: 10273206Abstract: The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.Type: GrantFiled: June 27, 2014Date of Patent: April 30, 2019Assignee: ALLERGAN, INC.Inventors: Thomas K. Karami, Scott W. Smith, Fiona Dubas-Fisher, Adrian St. Clair Brown
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Patent number: 10273207Abstract: Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.Type: GrantFiled: February 7, 2018Date of Patent: April 30, 2019Assignee: Araxes Pharma LLCInventors: Pingda Ren, Yi Liu, Liansheng Li, Jun Feng, Tao Wu
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Patent number: 10273208Abstract: Disclosed are methods for preparing and screening for an inhibitor of the activity of a biological molecule having a catalytic or non-catalytic cysteine residue. The methods including preparing a library of candidate inhibitor molecules by conjugating an electrophile to a plurality of drug molecules where the library of candidate inhibitor molecules thus formed react with cysteine residues. The library of candidate inhibitor molecules then may be reacted with the biological molecule to identify those inhibitor molecule that react with the catalytic or non-catalytic cysteine residue of the biological molecule in order to identify an inhibitor of the biological molecule.Type: GrantFiled: February 9, 2017Date of Patent: April 30, 2019Assignee: Northwestern UniversityInventors: Alexander V. Statsyuk, Stefan G. Kathman
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Patent number: 10273209Abstract: A molecular building block composition can include a metal ion component; and a ligand component including a core including at least one functional group associated with the metal ion component and the core.Type: GrantFiled: May 26, 2015Date of Patent: April 30, 2019Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Mohamed Eddaoudi, Dongxu Xue, Ryan Luebke, Vincent Guillerm, Abdul Malik Puthan Peedikakkal, Karim Adil, Lukasz Weselinski
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Patent number: 10273210Abstract: A pyridine compound represented by formula (I), or an N-oxide thereof is provided, wherein the variable groups are as defined in the specification. The pyridine compound of formula has excellent control effects against harmful arthropods.Type: GrantFiled: October 18, 2016Date of Patent: April 30, 2019Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Takeshi Tsuruda, Yoshihiko Nokura, Yuji Nakajima, Takamasa Tanabe
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Patent number: 10273211Abstract: The invention relates to metabolites of cabozantinib (I) as well as uses thereof.Type: GrantFiled: March 17, 2014Date of Patent: April 30, 2019Assignee: Exelixis, Inc.Inventors: Dana T. Aftab, Sriram Naganathan, Wei Xu, Steven Lacy, Linh Nguyen
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Patent number: 10273212Abstract: The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.Type: GrantFiled: June 28, 2017Date of Patent: April 30, 2019Assignee: SARCODE BIOSCIENCE INC.Inventors: Scott Tweedie, Sripathy Venkatraman, James Zeller
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Patent number: 10273213Abstract: The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound and subsequent cyclization.Type: GrantFiled: August 10, 2016Date of Patent: April 30, 2019Assignee: Merck Patent GmbHInventors: Luc Eberhardt, Andreas Waechtler, David Maillard, Stefan Lehmann
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Patent number: 10273214Abstract: Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-J, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are disclosed.Type: GrantFiled: June 2, 2014Date of Patent: April 30, 2019Assignee: Emory UniversityInventors: Stephen F. Traynelis, Dennis C. Liotta, Rose M. Santangelo, Ethel C. Garnier
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Patent number: 10273215Abstract: The present invention relates to a novel process for preparing 3,5-bis substituted pyrazoles containing haloalkoxy- and haloalkylthio groups.Type: GrantFiled: June 21, 2016Date of Patent: April 30, 2019Assignees: BAYER CROPSCIENCE AKTIENGESELLSCHAFT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Sergii Pazenok, Jean-Pierre Vors, Frédéric R. Leroux, Etienne Schmitt
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Patent number: 10273216Abstract: The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.Type: GrantFiled: August 2, 2016Date of Patent: April 30, 2019Assignee: BASF SEInventors: Eric George Klauber, Timo Frassetto, Reinhold Niemes, Ralf Bauer, Jochen Schroeder
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Patent number: 10273217Abstract: The present invention relates to compounds of formula I wherein R1? is CH3 R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1? and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ring; R2 is hydrogen, methyl, ethyl, isopropyl, tert-butyl, cyclopropyl, hydroxmethyl, or 2-propyl-2-ol; R3 is Cl, F, CF3, cyano, methyl, methoxy, isopropyl, or cyclopropyl; R4 is hydrogen, methyl, F or Cl; or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds of formula I may be used in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder.Type: GrantFiled: March 28, 2018Date of Patent: April 30, 2019Assignee: HOFFMANN-LA ROCHE INC.Inventors: Marius Hoener, Juergen Wichmann
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Patent number: 10273218Abstract: The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure: wherein A, B, W, Y, Z, R2, R4, R5, R6, Rq and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.Type: GrantFiled: July 31, 2015Date of Patent: April 30, 2019Assignee: University College Cardiff Consultants LimitedInventors: Andrew David Westwell, Andrea Brancale, Richard William Ernest Clarkson
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Patent number: 10273219Abstract: The present invention includes crystalline forms of (2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)-pentanamide and salts thereof. Furthermore, the present invention provides compositions comprising the crystalline forms and therapeutic uses of the crystalline forms.Type: GrantFiled: August 25, 2017Date of Patent: April 30, 2019Assignee: PharmatrophiX, Inc.Inventors: Rajgopal Munigeti, Frank M. Longo
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Patent number: 10273220Abstract: A derivative of inula lineariifolia lactone A, and in particular, a dimethylamine 4-O-acetyl inula lineariifolia lactone A or a salt thereof, preparation of same, and an application of same in preparation of medicine for treating multiple sclerosis.Type: GrantFiled: August 31, 2016Date of Patent: April 30, 2019Assignee: Shanxi Zhendong Leading Biotechnology Co., Ltd.Inventors: Weidong Zhang, Qingyan Sun, Minghua Li, Baohua Yang
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Patent number: 10273221Abstract: Compounds of the formula (I) wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling infestation of plants, harvested food crops, seeds or non-living materials by phytopathogenic microorganisms, in particular fungi.Type: GrantFiled: March 21, 2016Date of Patent: April 30, 2019Assignee: SYNGENTA PARTICIPATIONS AGInventors: Farhan Bou Hamdan, Laura Quaranta, Stephan Trah, Matthias Weiss
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Patent number: 10273222Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: GrantFiled: June 7, 2017Date of Patent: April 30, 2019Assignee: CELGENE QUANTSCEL RESEARCH, INC.Inventors: Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal