Abstract: A system and method for using optical coherence tomography for identity authentication. Embodiments include fingerprint validation, iris scan validation and facial scan validation. A preferred embodiment uses an optical coherence tomography system in conjunction with at least one additional two or three dimensional imaging of fingerprint, iris or facial biological indicators. Various embodiments provide additional combinations of two and three dimensional identification features so as to increase likelihood of accurate authentication of a subject under test.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: An oxygen measurement device includes a catheter including a flexible hollow shaft, the flexible shaft having an open port configured to allow urine from a bladder to flow into the open port, and a urinary passage in communication with the open port configured to discharge the urine; and an oxygen sensor including an oxygen sensor main body capable of detecting oxygen in the urine, the oxygen sensor being disposed in the catheter and configured such that the oxygen sensor main body is in contact with the urine flowing in the urinary passage.

Abstract: Methods, devices, systems, and computer program products are provided to improve sensitivity calibration of an in vivo analyte sensor and usability of an associated analyte monitoring system. In certain embodiments, methods are provided that improve the user experience of using an analyte monitoring system. Certain embodiments of the present disclosure include features that reduce the amount of calibration or re-calibration performed by the analyte monitoring system. More specifically methods of using a suspect calibration attempt to avoid having to recalibrate by adjusting the calibration or mitigating effects of sensor signal attenuation that caused the calibration attempt to be suspect are provided. Additional features are disclosed.

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Abstract: A method and apparatus for inserting at least a portion of a sensor into a patient is provided. Simple and easy to use mechanisms are provided that can position the sensor or any other device accurately with minimal complication. The method and apparatus can include an inserter device for use with the sensor. The method and apparatus can be for use in continuous or semi-continuous monitoring systems such as analyte monitoring systems.

Abstract: Receiver apparatus for use with an analyte sensor, and methods of operation and manufacturing. In one embodiment, the analyte sensor is an implanted/implantable blood glucose sensor, including oxygen-based detector elements. The receiver apparatus is a wireless-enabled small form-factor device with limited functionality that can be easily worn or kept with the user on a continual basis, thereby obviating the need for a more fully featured receiver or smartphone for extended periods of time (e.g., one week). The exemplary oxygen based analyte sensor, with high degree of stability over time, enables the user to divorce themselves from the more fully functioned receiver or smartphone, since no external calibration of the sensor is required during the extended period. In one variant, the device is a lightweight wristband. Other variants include e.g., pendants, finger-worn rings, arm or head bands, skin patches, and even dental, subcutaneous, or prosthetic implants.

Abstract: A blood glucose detection device includes a carrier body, a flow-guiding actuator, a microneedle patch, a sensor and a controlling chip. The carrier body has a liquid guiding channel, a compressing chamber and a liquid storage chamber. The flow-guiding actuator seals the compressing chamber. The microneedle patch is attached on the carrier body and has plural hollow microneedles. The sensor is disposed within the liquid storage chamber. The controlling chip is disposed on the carrier body. The plural hollow microneedles puncture the skin of a human subject with minimal invasion. The controlling chip controls the flow-guiding actuator to actuate and the tissue fluid is sucked into the liquid storage chamber through the plural hollow microneedles, whereby the sensor detects the blood glucose of the tissue fluid to generate and transmit the measured data to the controlling chip. The controlling chip can generate monitoring information by calculating the measured data.

Abstract: A transdermal sampling system includes a microfluidic assembly for retrieving and transferring at least one biomarker transdermally from the skin of a subject. The biomarker is selected from a group of biomarkers consisting of: a nicotine biomarker, ?-hCG, luteinizing hormones, ESAT6; CFP10, Hsp16.3, marijuana and its derivatives, opiates, narcotics, ethanol, barbiturates, pyridinoline crosslinks, Calcitonin, FSH, estrogen, vitamin D, calcium, glial fibrillary acid protein (GFAP), microtubule-associated protein tau, SNTF-calpain cleaved N terminal fragment proteins, estradiol, P4-progesterone, troponin, lactate, CO2 levels, and pH levels. A transdermal detector identifies and quantifies the at least one biomarker.

Abstract: Methods, apparatuses, and systems are provided for determining whether to administer a medication dose as a single dose or whether to fractionate the single dose to be administered as at least two discrete doses. Embodiments include determining a first analyte level and a first rate of change of the analyte level; determining an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold; administering the initial medication dose; determining a second analyte level and a second rate of change of the analyte level based on subsequent analyte data; and determining a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change relative to the rate of change threshold.

Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.

Abstract: A retractor has an oximeter sensor at its tip, which allows measuring of oxygen saturation of a tissue being retracted by the retractor. The tip includes one or more openings for at least one source and detector. A specific implementation is a spinal nerve root retractor with an oximeter sensor.

Abstract: Systems and methods of optical transcutaneous oxygenation monitoring. The oxygenation monitor comprises a photoluminescent oxygen-sensitive probe, a photon source positioned to direct photons at the probe, a photodetector positioned to detect light emitted from the probe when the photon source directs photons at the probe, a controller in electrical communication with the photon source and the photodetector, the controller being configured to execute a program stored in the controller to calculate a level of oxygen adjacent the probe from an electrical signal received from the photodetector. The photon source, the photodetector, and the controller are disposed in or on a support structure.

Abstract: This disclosure relates to a nanoporous composition including a number of clusters of nanoparticles dispersed in a liquid, a nanoporous layer formed of the nanoporous composition, a glucose-oxidation electrode including the nanoporous layer, and a glucose-sensing device and system including the glucose-oxidation electrode. This disclosure also relates to a method of making the nanoporous composition, the nanoporous layer, the glucose-oxidation electrode and the glucose-sensing device and system. Further, this disclosure also relates to devices, systems and methods for continuous glucose monitoring (CGM) and blood glucose monitoring (BGM).

Abstract: This disclosure relates to a glucose-sensing electrode including a nanoporous metal layer and a maltose-blocking layer formed over the nanoporous metal layer. The nanoporous metal layer is capable of oxidizing both glucose and maltose without an enzyme specific to glucose or maltose in the glucose-sensing electrode. The maltose-blocking layer has porosity that permits glucose to pass therethrough and inhibits maltose from passing therethrough toward the nanoporous metal layer.

Abstract: This disclosure relates to a glucose-sensing electrode including a nanoporous metal layer and an electrolyte ion-blocking layer formed over the nanoporous metal layer. The nanoporous metal layer is capable of oxidizing both glucose and maltose without an enzyme specific to glucose in the glucose-sensing electrode. The electrolyte ion-blocking layer is configured to inhibit Na+, K+, Ca2+, Cl?, PO43? and CO32? from diffusing toward the nanoporous metal layer such that there is a substantial discontinuity of a combined concentration of Na+, K+, Ca2+, Cl?, PO43? and CO32? between over and below the electrolyte ion-blocking layer.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprise at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: A biological property testing device includes a base comprising a primary surface extending in a base plane, and a first lancet station supported by the base. A first test strip channel provided in the base can have a main channel portion extending generally parallel with the base plane, and an angled channel portion that forms an angle with the main channel portion between 5 degrees and 90 degrees. The first test strip channel can house a biological test strip oriented so that a meter connecting end of the biological test strip is adjacent to the main channel portion and a sample end of the biological test strip is adjacent to the angled channel portion.

Abstract: The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

Abstract: A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

Abstract: A data processing method comprises, under program control of test instructions programmed in a mobile computing device, generating and causing displaying on a display device of the mobile computing device, a prompt associated with a first cognitive relating to a cognitive test of a feature of a human cognitive domain, the prompt comprising a prompt image of spatially positioned display objects; in conjunction with causing displaying the prompt, reading and storing a first time stamp value indicative of a first time when the prompt is first displayed on the display device of the mobile computing device, the system clock continuously generating signals representing a current time that may be queried programmatically by the application; displaying the prompt for a specified time period using the system clock; in response to displaying the prompt for the specified time period, capturing response input at the mobile computing device, the response input representing movements to recreate the prompt image of the spa

Abstract: The present disclosure pertains to a system configured to predict a lucidity level of a subject.

Abstract: A system includes at least one wearable device configured to monitor a bladder volume of a user associated with the at least one wearable device, monitor moisture associated with the user, and transmit information regarding the bladder volume and moisture. The system also includes a display device configured to receive the information regarding the bladder volume and moisture from the at least one wearable device, and display information to the user based on the received information.

Abstract: Methods and systems for diagnosing a condition of a central nervous system are provided. A method includes providing a DBSI-MRI data set obtained from the central nervous system of the subject, and transforming the DBSI-MRI data set to obtain at least one DBSI biomarker value. The method further includes comparing each DBSI biomarker value to at least one corresponding threshold value from a diagnostic database to obtain a relation between each DBSI biomarker value and the at least one corresponding threshold value, and diagnosing the condition according to at least one diagnostic rule, wherein each diagnostic rule defines a candidate condition in terms of the relations between the at least one DBSI biomarker value and the at least one corresponding threshold value.

Abstract: Systems and methods for supporting and adapting to changes in cognitive ability are provided. The system includes a user interface and a processor system, the processor system being configured to detect changes in cognitive ability based on detected interactions with the user interface. The system is configured to change its interaction with the individual based on detected changes in cognitive ability. The system is configured to change system access controls for third parties based on detected changes in cognitive ability in a manner that respects the individual.

Abstract: A fiber quality sensor (S) comprises a first pair of mutually adjacent electrodes arranged for contacting the fiber to generate a first voltage over the electrodes, the first voltage being indicative of the quality of the fiber, the first pair of electrodes including a first conductive electrode (1), and a first dielectric electrode (D, 2) having a first dielectric material (D) with a conductive backing (2). The fiber quality sensor (S) may further comprise a second pair of electrodes arranged for contacting the fiber to generate a second voltage over the electrodes, the second voltage being indicative of the quality of the fiber, the second pair of mutually adjacent electrodes including a second conductive electrode (1), and a second dielectric electrode (D, 2) having a second dielectric material with a conductive backing, wherein in a tribo-electric series of materials, the material of the conductive electrode is arranged between the first and second dielectric materials.

Abstract: A gum diagnosis assisting apparatus includes a sectional data extractor configured to extract sectional data in a depth direction of a gum marginal portion from three-dimensional point group data of a frontal view of an oral cavity, and a gum diagnosis data generator configured to process the sectional data into a format suitable to a gum diagnosis to generate gum diagnosis data. The gum diagnosis data generator is configured to generate, for example, a two-dimensional graph as the gum diagnosis data with a right-left direction or the up-down direction of the frontal view of the oral cavity as a first axis and the depth direction of the frontal view of the oral cavity as a second axis.

Abstract: A method and system for detecting errors when practicing fluency shaping exercises. The method includes setting each threshold of a set of thresholds to a respective predetermined initial value; analyzing a voice production to compute a set of first energy levels composing the voice production, wherein the voice production is of a user practicing a fluency shaping exercise; detecting at least one speech-related error based on the computed set of first energy levels, a set of second energy levels, and the set of thresholds, wherein the detection of the at least one speech-related error is with respect to the fluency shaping exercise being practiced by the user, wherein the set of second energy levels is determined based on a calibration process; and generating feedback indicating the detected at least one speech-related error.

Abstract: A wearable device capable of recognizing doze-off stage including a processor and an electrocardiogram sensor is provided. The processor trains a neural network module. The processor is coupled to the electrocardiogram sensor. The electrocardiogram sensor is configured to generate an electrocardiogram signal. The processor performs a heart rate variability analysis operation and a R-wave amplitude analysis operation to analyze a heart beat interval variation of the electrocardiogram signal, so as to generate a plurality of characteristic values. The processor utilizes the trained neural network module to perform a doze-off stage recognition operation according to the characteristic values, so as to obtain a doze-off stage recognition result. In addition, a recognition method is also provided.

Abstract: A wearable device capable of recognizing sleep stage including a processor, an electrocardiogram sensor, an acceleration sensor and an angular acceleration sensor is provided. The processor trains a neural network module. The electrocardiogram sensor generates an electrocardiogram signal. The processor analyzes the electrocardiogram signal to generate a plurality of first characteristic values. The acceleration sensor generates an acceleration signal. The processor analyzes the acceleration signal to generate a plurality of second characteristic values. The angular acceleration sensor generates an angular acceleration signal. The processor analyzes the angular acceleration signal to generate a plurality of third characteristic values. The processor utilizes the trained neural network module to perform a sleep stage recognition operation according to the first characteristic values, the second characteristic values and the third characteristic values, so as to obtain a sleep stage recognition result.

Abstract: Examples of systems and methods for on-demand CPAP therapy are described herein. One example method of providing on-demand CPAP therapy includes monitoring a physiological parameter of a wearer, the physiological parameter associated with sleep apnea, the wearer wearing an air mask connected to an air supply device; detecting a sleep apnea event based on the physiological parameter; and in response to detecting the sleep apnea event, activating the air supply device.

Abstract: A system and method determines a user's compliance with a prescribed therapeutic pneumatic compression treatment by applying external pressure to a body limb using a pneumatic compression sleeve having a pneumatically fillable cell; measuring pneumatic pressure within the pneumatically fillable cell; generating a pressure signal corresponding to the measured pneumatic pressure; determining biological events associated with the user based upon the pressure signal; generating a positive detection signal for each determined biological event associated with the user; and determining a user's compliance with a prescribed therapeutic pneumatic compression treatment when a predetermined number of positive detection signals have been generated within a predetermined time interval.

Abstract: This invention relates to a method or system for providing an indication or establishment of airway patency of a patient comprising monitoring of at least one targeted gas (e.g. CO2, N2 or may be other gases capable of being detected, monitored, and measured) that is being expired or being expelled from an airway of a patient (e.g. an apnoeic or non-spontaneously breathing patient), and based on measurements of the at least one targeted gas for a period of time, providing an indicator as to an output of the measurements of the at least one targeted gas for the period of time, or a determination as to airway patency, or a determination as to a location of a blockage or obstruction in the airway, or combinations of these.

Abstract: A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.

Abstract: A system for obtaining and analyzing data for overall joint motion from a plurality of joints of a subject experiencing a movement disorder involves a plurality of kinematic sensors configured to be placed on a body of a subject experiencing a movement disorder proximal a plurality of joints of the subject. The kinematic sensors are selected to measure overall joint motion with sufficient degrees of freedom for individual joints so that data collected by the sensors can be deconstructed into multiple degrees of freedom for individual joints and analyzed to provide amplitude of the movements caused by the movement disorder and/or relative contributions from and/or directional bias for each muscle group that may be implicated in the movement of each joint.

Abstract: Device and method for determining an efficacy of chronic pain treatment including providing a first set of at least one stimulus to a subject, obtaining first measurements of at least two physiological parameters in response to the first set of at least one stimulus, providing chronic pain treatment to the subject, providing a second set of at least one stimulus to the subject, obtaining second measurements of the at least two physiological parameters in response to the second set of at least one stimulus; and determining an efficacy of the chronic pain treatment by applying a classification algorithm on the first and second measurements of the at least two physiological parameters.

Abstract: An implantable device for sensing data includes a subcutaneous sensor configured to couple with an implant. The implantable device is operably configured to wirelessly and transcutaneously transmit data sensed by the subcutaneous sensor. The sensor may be powered wirelessly and transcutaneously. Transmission of data and/or power may be provided by ultrasound sound waves. The sensor may be in electrical communication with a piezoelectric transducer configured to receive the ultrasound sound waves.

Abstract: A method for using saliva to measure at least one substance or physiological parameter of a human or animal subject may involve inserting a first end of a sensor into a handheld saliva testing device. The method may also involve receiving saliva from the subject on a second end of the sensor, moving the saliva from the second end of the sensor to the first end, and processing the saliva with the handheld saliva testing device to provide initial saliva data related to the at least one substance or physiological parameter of the subject. In some embodiments, the sensor remains inserted in the handheld device while the subject deposits saliva on the opposite, free end of the sensor.

Abstract: A mechanism is provided in a data processing system comprising a processor and a memory wherein the memory comprises instructions which are executed by the processor to cause the processor to be specifically configured to implement a recognizer module for detecting user input. The recognizer module receives sensor signals from at least one wearable device being worn by a user. The recognizer module analyzes the sensor signals using a machine learning model to determine at least one user input indicator describing user input activity of the user. The recognizer module outputs the at least one user input indicator.

Abstract: An apparatus for obtaining EEG signals utilizes adjustable arms and EEG sensors mounted on an adjustable frame adapted to fit the head of an individual.

Abstract: Device for detecting characteristic signals of tissues and materials and methods for calculating thereof. Apparatus and methods for detecting the presence of tissue (skin) in pulse oximeter are disclosed. Specifically, analysis using optical techniques are used to identify characteristic signals of different compositions of matter. The present application discloses using a plurality of photodetectors at different distances from a source to measure light scattering through a variety of materials, and more specifically, to detect the presence of tissue.

Abstract: An extraventricular drain system can include a catheter. The catheter can have a shaft including a proximal end and a distal end, a lumen extended along a length of the catheter, and a drain located on the shaft. The drain can be fluidly coupled with the lumen. In an example, an electrode can be located along the shaft at an axial location. A reference contact can be located on the shaft at an axial location further from the distal end than the electrode. The electrode and the reference contact can be configured for electrical communication with a processing unit. In a further example, a first pressure port and a second pressure port can be located at the distal end and have different respective axial locations and respective radial locations. The first and second pressure ports can be in fluid communication with a first and second pressure sensors respectively.

Abstract: A device includes an orally-administrable capsule and a tissue capture device coupled to the orally-administrable capsule. The tissue capture device is configured to connect to gastrointestinal tissue within a body. The tissue capture device is configured to detach from the orally-administrable capsule after the tissue capture device connects to the gastrointestinal tissue. A device includes an orally-administrable capsule, a tissue capture device coupled to the orally-administrable capsule, a chamber within the orally-administrable capsule, and an actuator. The tissue capture device includes multiple fasteners configured to connect the tissue capture device to gastrointestinal tissue within a body. The chamber is configured to draw gastrointestinal tissue towards the fasteners when a fluid pressure of the chamber is decreased. The actuator is configured to cause a decrease of the fluid pressure of the chamber.

Abstract: A medical system for removing far-field signals from a unipolar electrical signal is disclosed. In embodiments, the medical system comprises a catheter and a processing device communicatively coupled to the catheter. The catheter comprises a plurality of electrodes configured to sense a plurality of unipolar signals transmitted through tissue. The processing device is configured to: receive the sensed unipolar electrical signals, determine an electrode having a high level of contact with the tissue, and determine an electrode having a lower level of contact with the tissue than the electrode having the high level of contact with the tissue. Further, the processing device is configured to determine a sensed near-field electrical signal based on the unipolar electrical signal received from the electrode having the high level of contact and the unipolar electrical signal received from the electrode having the lower level of contact.

Abstract: There is provides a biological information monitoring system for monitoring biological information on subjects on a bed. The system includes a plurality of load detectors to be placed in the bed or under legs of the bed, each of the plurality of load detectors being configured to detect loads of the subjects and output the detected loads as a load signal; and a signal separation unit configured to determine a number of the subjects on the bed based on a frequency spectrum of the load signal outputted from each of the plurality of load detectors, and separate, with respect to each of the subjects, components each corresponding to each of a plurality of frequency ranges from the load signal outputted from each of the plurality of load detectors.

Abstract: There is provided a biological information monitoring system for monitoring a biological information on a subject on a bed. The system includes a plurality of load detectors which are to be placed in the bed or under legs of the bed, and which are configured to detect a load of the subject; a load separation unit configured to separate a load component which oscillates according to a heartbeat of the subject, from the load of the subject; and a center of gravity position calculation unit configured to obtain a position of a center of gravity of the subject based on the load component which oscillates according to the heartbeat of the subject.

Abstract: A physiological detection system including a light source module, a photo sensor and a processor is provided. The light source module is configured to provide light to illuminate a skin region. The photo sensor is configured to detect emergent light passing the skin region with at least one signal source parameter and output an image signal. The processor is configured to calculate a confident level according to the image signal to accordingly adjust the at least one signal source parameter.

Abstract: A parallel biometric signal processor and a method of controlling the parallel biometric signal processor are described. The processor and corresponding method include amplifiers configured to amplify a biometric signal based on an amplifying attribute and converters configured to convert the amplified signal to a converted signal based on a converting attribute. The processor also includes preprocessors configured to preprocess the converted signal based on a preprocessing attribute, and feature extractors configured to extract a set of biometric information from an output signal of the preprocessors.

Abstract: An apparatus is configured to execute: a first process for estimating a first component at a first time point by using a waveform and the first component calculated from the waveform before the first time point, the waveform being based on a running trace of a vehicle, the first component being less than a first frequency; a second process for estimating the first component at the first time point by using the waveform, the first component calculated from the waveform before the first time point, and a second component at the first time point, the second component being greater than the first frequency and predicted from the second component calculated from the waveform before the first time point; and a calculation process for calculating the second component at the first time point from the waveform based on the first components estimated by the first and second process.

Abstract: An image processing apparatus includes: a processor comprising hardware, the processer being configured to execute: setting, in an image, an area of interest where classification is evaluated; calculating surface layer structure information representing a surface layer structure in the area of interest; calculating at least focus degrees of the outside of the area of interest in the image; and classifying the image based on the surface layer structure information and the focus degrees of the outside of the area of interest.