Patents Issued in June 11, 2019
  • Patent number: 10315960
    Abstract: A carbon fiber preform that includes a plurality of fibrous layers stacked together and a plurality of sacrificial fibers that bind the plurality of fibrous layers together, where at least one fibrous layer of the plurality of fibrous layers includes a plurality of carbon fibers or carbon fiber precursor fibers.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: June 11, 2019
    Assignee: Honeywell International Inc.
    Inventors: Mark L. La Forest, Slawomir T. Fryska, David M. Wright
  • Patent number: 10315961
    Abstract: Provided herein is porous material which includes, as a framework of a porous structure, ZrO2 particles and a dissimilar material present on the surfaces of the ZrO2 particles. The dissimilar material includes at least one oxide selected from a first group of oxides and at least one oxide selected from a second group of oxides, or both. The first group of oxides includes, but is not limited to, SiO2, TiO2, La2O3, Al2O3, SrCO3, Gd2O3, Nb2O5, Y2O3, and a complex oxide including two or more of these oxides. The second group of oxides includes, but is not limited to, SiO2, TiO2, La2O3, Al2O3, SrCO3, Gd203, Nb2O5, Y2O3, and a complex oxide including two or more of the oxides, and ZrO2.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: June 11, 2019
    Assignee: NGK INSULATORS, LTD.
    Inventors: Takahiro Tomita, Hiroharu Kobayashi, Akinobu Oribe
  • Patent number: 10315962
    Abstract: This disclosure relates to a semi-humic material, and compositions comprising the same, obtained from leonardite ore and a non-humic organic carbon source and a process for obtaining the same. Also described are methods for maintaining more available nitrogen and phosphorus in the plant root zone and minimizing premature leaching and loss of the nitrogen and/or phosphorus into the atmosphere, surface waters and/or subsurface ground water.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: June 11, 2019
    Assignee: Actagro, LLC
    Inventors: Taha Rezai, John Breen, Thomas J. Gerecke, Qingwen He, Margaret Mae Abercrombie, Susan Her, Ryan Dierking, Gregory A. Crawford, Montell L. Bayer
  • Patent number: 10315963
    Abstract: A composting facility includes: a floor for receiving compostable material thereon, wherein the floor is constructed above-grade; a dovetail extending from the floor to allow ingress of a vehicle from a grade level to the floor; one or more channels defined within the floor and extending through the dovetail; a covering extending over the one or more channels to maintain the compostable material away from the channel, the covering defining at least one aperture extending from above the covering into the one or more channels for allowing flowthrough of gases; and an air source for providing air through the channels to provide cooling characteristics to the compostable material or oxygen to aid an aerobic process associated with composting. In operation, liquids draining from the composting material pass through the at least one aperture into the channel and out through a portion of the channel extending through the dovetail.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 11, 2019
    Assignee: McGill Environmental Systems of N.C., Inc.
    Inventor: Michael Noel Lyons
  • Patent number: 10315964
    Abstract: According to the present invention, a deuterium-substituted marker for fuel is synthesized through substitution with deuterium so as to have structurally and chemically similar properties to those of a molecule configuring fuel oil. A molecule of the deuterium-substituted marker is significantly similar to the conventional molecule configuring the fuel oil, which may prevent illegal removal of the marker by the fake oil manufacturers. According to the present invention, it is able to pursue public safety and environmental protection from fake oil products, and to prevent national tax evasion, by preventing the illegal mixing of fuel oil to secure a legal distribution of the oil market according to the present invention.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: June 11, 2019
    Assignee: Korea Institute of Petroleum Management
    Inventors: Young-Kwan Lim, Hee-Yeon Baek, Kyoung-Heum Lee, Seung-Hyun Ryu, Ju Min Youn, Jong Ryeol Kim, In Ha Hwang, Jong Han Ha
  • Patent number: 10315965
    Abstract: Systems and methods are presented that reduce energy and water consumption in processes for producing fuel from renewable alcohol-containing feedstreams. Alcohol content is converted directly to hydrocarbon transport fuels in a catalytic process, with heat transferred between intermediate process streams to reduce heat energy consumption. Overall water consumption is reduced by recovery of water from the catalytic process and reduction of water temperature to reduce evaporative losses.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 11, 2019
    Assignee: VERTIMASS LLC
    Inventors: Charles E. Wyman, John R. Hannon
  • Patent number: 10315966
    Abstract: Provided are fuel components, a method for producing fuel components, use of the fuel components and fuel containing the fuel components based on 5-nonanone.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: June 11, 2019
    Assignee: NESTE OY
    Inventors: Jukka Myllyoja, Mats Käldström, Marina Lindblad, Jarno Kohonen, Maaria Seläntaus, Elias Ikonen
  • Patent number: 10315967
    Abstract: Reactant materials for use in the synthesis of compounds comprising a non-metal and hydrogen, and methods of making and using the same are provided. The reactant materials generally comprise first and second non-metals, metals, a cation, and a transition metal, and can be formed and used in reactions occurring at relatively low-pressure conditions using heat energy that can be supplied via solar radiation. In particular, the reactant materials can be used in the synthesis of ammonia and various hydrocarbon compounds using air, water, and sunlight.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: June 11, 2019
    Assignee: Kansas State University Research Foundation
    Inventors: Ronald Michalsky, Peter Pfromm
  • Patent number: 10315968
    Abstract: A steam cracking process for converting hydrocarbons into smaller hydrocarbons, particularly olefins, in a tube reactor comprising a convection section, a cross-over section, and a radiant section. The process includes heating the fluid mixture inside the tube to a temperature at the end of the convection section where significant cracking occurs in the cross-over section. The high convection section and cross-over section temperatures allow for lower tube wall temperature in the radiant section resulting in less coke deposition on the inner wall of the tube, and hence extended run-lengths between adjacent decoking sessions.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: June 11, 2019
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Gary F. Janda, David B. Spicer
  • Patent number: 10315969
    Abstract: Provided are a method of preparing a multicomponent bismuth-molybdenum composite metal oxide catalyst, and a multicomponent bismuth-molybdenum composite metal oxide catalyst prepared thereby. According to the preparation method, since the almost same structure as that of a typical quaternary bismuth-molybdenum catalyst may be obtained by performing two-step co-precipitation, i.e., primary and secondary co-precipitation, of metal components constituting the catalyst, the reduction of catalytic activity due to the deformation of the structure of the catalyst may be suppressed.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: June 11, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Ye Seul Hwang, Dong Hyun Ko, Kyong Yong Cha, Dae Heung Choi, Myung Ji Suh, Jun Han Kang, Joo Hyuck Lee, Hyun Seok Nam, Jun Kyu Han, Sang Jin Han
  • Patent number: 10315970
    Abstract: The present invention relates to a catalyst based on iron oxide for the dehydrogenation of hydrocarbons and also a process for producing it. The catalyst comprises at least one iron compound, at least one potassium compound and at least one cerium compound, wherein the at least one iron compound and the at least one potassium compound are at least partly present in the form of one or more K/Fe mixed oxide phases of the general formula KxFeyOz, where x is from 1 to 17; y is from 1 to 22 and z is from 2 to 34, where the catalyst comprises at least 20% by weight, based on the total catalyst, of the K/Fe mixed oxide phases and comprises crystalline cerium dioxide having a crystallite size in the range from 10 nm to 30 nm.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: June 11, 2019
    Assignee: BASF SE
    Inventors: Florina C. Patcas, Bernd Hinrichsen, Martin Dieterle
  • Patent number: 10315971
    Abstract: Systems and processes for heat recovery associated with the separation of hydrocarbon components. Two compressors are used to compress a portion of an overhead vapor stream from a fractionation column. A pressure of the liquid portion of the compressed overhead is reduced and used to recover heat from an overhead of another separation zone having a fractionation column. Once the heat has been recovered the stream is recompressed. The recovered heat may be removed from the recompressed stream in a reboiler of another fractionation column. The fractionation columns may comprise a deethanizer stripper, propane-propylene splitter, and a depropanizer column.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: June 11, 2019
    Assignee: UOP LLC
    Inventors: Stephen T. King, Michael R. Van de Cotte, Adam J. Kanyuh, Steven C. Kozup
  • Patent number: 10315972
    Abstract: The present invention relates to a separation method and a separation process system for easily recovering ethanol from an ethanol oligomerization reactant containing unreacted ethanol. A separation method according to the present invention may easily reflux ethylene while reducing or excluding the use of a reflux system which uses an expensive cooling medium, and the like, and thus may improve the economics while increasing separation efficiency.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: June 11, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Hoi In Jeong, Jong Ku Lee, Jeong Seok Lee, Mi Kyung Kim
  • Patent number: 10315973
    Abstract: This invention provides a method for preparing ethylene glycol by hydrolyzing ethylene glycol monomethyl ether.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: June 11, 2019
    Assignee: Dalian Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Youming Ni, Wenliang Zhu, Yong Liu, Hongchao Liu, Lei Shi, Zhongmin Liu
  • Patent number: 10315974
    Abstract: [Object] It is intended to provide a crystalline maltitol powder less prone to consolidation, which is free from the formation of a lump during delivery or storage thereof, does not require pulverization or re-classification in use, is easy to handle in transfer, package opening, addition or mixing to another food material, and so on, and allows for automated transportation and so on. [Means for solving the object] The crystalline maltitol powder less prone to consolidation is obtained by charging crystalline or powdery maltitol into a shelf type dryer, a tunnel-type dryer, a cylindrical container, or the like and subjecting the equipment or container to a treatment wherein an air having a temperature of 30 to 33° C. and a relative humidity of 5% is allowed to flow into the equipment or container from one side thereof and withdrawn out of the other side thereof at a space velocity of 11 to 12 for consecutive 24 hours.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 11, 2019
    Assignee: MITSUBISHI SHOJI FOODTECH CO., LTD.
    Inventors: Chihaya Sano, Takashi Noguchi, Tohru Nemoto, Koshiro Shimazu
  • Patent number: 10315975
    Abstract: The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: June 11, 2019
    Assignees: BASF SE, Ruprecht-Karls-Universität Heidelberg
    Inventors: Julia Strautmann, Stefan Rüdenauer, Christian Rein, Melanie Weingarten, Rocco Paciello, Wolfgang Siegel, Michael Breuer, Peter Hofmann, Sebastian Schmidt
  • Patent number: 10315976
    Abstract: 5,9-dimethyl-9-hydroxy-decen-4-al, having the formula (I)
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: June 11, 2019
    Assignee: GIVAUDAN S.A.
    Inventors: Alain Alchenberger, Chloe Berbez, Clare Finn, Dominique Lelievre, Martin Alan Lovchik, Roseline Poignon-Martel, Gilles Romey
  • Patent number: 10315977
    Abstract: The present invention relates to a method of preparing n-butyric acid by using poly-3-hydroxybutyrate. The method comprises following steps: placing poly-3-hydroxybutyrate in a closure means, passing hydrogen into the closure means to eliminate air after making an initial hydrogen pressure be 2 to 6 MPa, carrying out an agitation at 190 to 240° C. for reaction for 6 to 36 hours to obtain n-butyric acid. The preparation method provided by the present invention does not require a catalyst or a reaction solvent, and converts poly-3-hydroxybutyrate into n-butyric acid by a one-step reaction under a hydrogen atmosphere. The conversion rate of poly-3-hydroxybutyrate is 100%, the yield of n-butyric acid reaches up to 97%, the purity of n-butyric acid in all obtained liquid products reaches up to 98%, and no additional subsequent separation process is needed to the target product n-butyric acid.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: June 11, 2019
    Assignee: DONGGUAN UNIVERSITY OF TECHNOLOGY
    Inventors: Shimin Kang, Hang Zhang, Jietai Li, Zhilin Li, Yongjun Xu, Chenghua Sun, Nanlong Hong
  • Patent number: 10315978
    Abstract: A method of reducing the formation of an impurity in a terephthalic acid (TPA) production process includes: combining in a reactor, a catalyst, a mixture comprising the impurity and the TPA, and a compound comprising an active carbon atom; reacting the impurity with the compound in the presence of the catalyst by a condensation-dehydration reaction process comprising a nucleophilic addition of the active carbon atom of the compound to a carbonyl group of the impurity to form an intermediate followed by a dehydration reaction of the intermediate to form a product mixture comprising a water, the TPA, and an alkene; and recovering the product mixture from the reactor.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: June 11, 2019
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Nedumbamana Sankaran, Syed Azhar Hashmi, Vinodkumar Vasudevan
  • Patent number: 10315979
    Abstract: Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from C6 and C5 sugars in the presence of a Lewis Acid material, wherein the yield of the 2,5,6-trihydroxy-3-hexenoic acid or 2,5-dihydroxy-3-pentenoic acid or esters thereof exceeds 15%.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: June 11, 2019
    Assignee: HALDOR TOPSØE A/S
    Inventors: Esben Taarning, Irantzu Sadaba Zubiri, Sebastian Meier
  • Patent number: 10315980
    Abstract: The present disclosure relates to a catalyst used in the preparation of acrylic acid and acrylic acid preparation method using the same, and more specifically, discloses a catalyst capable of enhancing selectivity of acrylic acid and a production yield of acrylic acid when preparing acrylic acid from allyl alcohol using a heterogeneous catalyst including bimetallic alloy catalyst particles of gold and another metal, and an acrylic acid preparation method using the same.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: June 11, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Dongsu Song, Daesung Kim, Wonjae Lee, Yongjin Choe, Hyunjoo Lee, Minsu Kim
  • Patent number: 10315981
    Abstract: A process for preparing a diaryl carbonate from a dialkyl carbonate and an aryl alcohol is disclosed. The process takes place in apparatus comprising at least two distillation columns, and at least one of the distillation columns is operated at subatmospheric pressure which is achieved using vacuum equipment.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: June 11, 2019
    Assignee: SHELL OIL COMPANY
    Inventors: Kunquan Yu, Garo Garbis Vaporciyan
  • Patent number: 10315982
    Abstract: The present invention relates to a composition comprising: a) at least one primary, secondary or tertiary amine and b) at least one agent which masks the odor of said at least one amine, said at least one odor-masking agent comprising at least one ether (b1), optionally, but preferably, at least one terpene and/or one terpenoid (b2) and optionally, but preferably, at least one oxime (b3). The invention also relates to the use of an odor-masking agent in order to mask the odor of at least one amine.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: June 11, 2019
    Assignee: ARKEMA FRANCE
    Inventors: Christophe Ruppin, Christian Forquy
  • Patent number: 10315983
    Abstract: The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a hydrohydroxymethylation reaction.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 11, 2019
    Assignees: PIVERT S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'ARTOIS
    Inventors: Frederic Hapiot, Eric Monflier, Theodore Vanbesien
  • Patent number: 10315984
    Abstract: In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: June 11, 2019
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Melissa Fleury, Adam D. Hughes
  • Patent number: 10315985
    Abstract: The invention provides a bio-based acrylic monomer, particularly a plant oil-based acrylic monomer, which is well-suited for emulsion polymerization and latex formation in aqueous medium. Polymers and copolymers formed from the bio-based acrylic monomer are also provided. The invention further provided methods for making the monomer from bio-based triglycerides or fatty esters.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: June 11, 2019
    Assignee: NDSU RESEARCH FOUNDATION
    Inventors: Andriy Voronov, Ihor Tarnavchyk
  • Patent number: 10315986
    Abstract: A method for forming a solution of ammonium carbamate is provided herein. The method includes, but is not limited to, providing a reactor comprising a solution of ammonia. The method further includes, but is not limited to, feeding carbon dioxide through the solution of ammonia to form a mixture. The method further includes, but is not limited to, combining a solution of sodium hydroxide and the mixture to form the ammonium carbamate.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: June 11, 2019
    Assignee: SOLENIS TECHNOLOGIES, L.P.
    Inventors: Cecil Coutinho, Michael Mitchell, Stephen Vinciguerra
  • Patent number: 10315987
    Abstract: Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: June 11, 2019
    Assignee: Surmodics, Inc.
    Inventor: Aleksey V. Kurdyumov
  • Patent number: 10315988
    Abstract: Methods of making an alpha-olefin sulfonic dimer acid (AOS dimer acid) are disclosed. In one method, an alpha-olefin is sulfonated, preferably with sulfur trioxide, to produce a mixture comprising an alpha-olefin sulfonic acid (AOS acid) and sulfur dioxide. This mixture is then heated while purging sulfur dioxide and hydrogen sulfide from the reactor to produce an AOS dimer acid composition. In another method, the AOS acid mixture is treated to remove sulfur dioxide and is then heated to produce an AOS dimer acid composition. With either method, the resulting AOS dimer acid composition has at least a 30% decrease in the level of elemental sulfur when compared with that of an AOS dimer acid composition prepared by a similar process in the absence of any active removal of sulfur dioxide or hydrogen sulfide. AOS dimer acid compositions and salts of the AOS dimer acids, which are useful surfactants for oilfield and other applications, are also disclosed.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: June 11, 2019
    Assignee: STEPAN COMPANY
    Inventors: Gregory P. Dado, Aaron Sanders, Xue Min Dong, E. Carolina Rojas
  • Patent number: 10315989
    Abstract: The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to compositions comprising these compounds.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: June 11, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Reiner Friedrich, Fanny Schooren
  • Patent number: 10315990
    Abstract: The present invention provides an isothiocyanate compound and its application. The compound is an aryl-substituted isothiocyanate compound that has a structure of the general formula I. The isothiocyanate compound of the present invention has very good solubility in water, far better inhibitory activity for XPO1 protein than other non-aryl substituted congeneric compounds, little side effects, and good biological safety and bioavailability, and is quite suitable for clinical application. Therefore, the isothiocyanate compound would have tremendous potential market space and economic benefits.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: June 11, 2019
    Assignee: DRIVINGFORCE THERAPEUTICS
    Inventor: Yongliang Yang
  • Patent number: 10315991
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: June 11, 2019
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Qing Xu, Zhe Li
  • Patent number: 10315992
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: June 11, 2019
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • Patent number: 10315993
    Abstract: The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: June 11, 2019
    Assignee: Cadila Healthcare Limited
    Inventors: Mukul R. Jain, Suresh Giri, Himanshu M. Kothari, Kaushik Banerjee, Rashmikant Kachhiya
  • Patent number: 10315994
    Abstract: The present invention describes compounds and uses thereof in applications relating to absorption of electromagnetic energy. Preferred compounds are double bond-containing cyclic compounds capable of absorbing electromagnetic radiation energy and having improved photostability due to the presence and location of one or more fluorine groups in relation to the double bond of the ring.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: June 11, 2019
    Assignee: Commomwealth Scientific and Industrial Research Organization
    Inventors: John Ryan, Mark York
  • Patent number: 10315995
    Abstract: Methods for deposition of elemental metal films on surfaces using metal coordination complexes comprising nitrogen-containing ligands are provided. Also provided are nitrogen-containing ligands useful in the methods of the invention and metal coordination complexes comprising these ligands.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: June 11, 2019
    Assignee: Applied Materials, Inc.
    Inventors: Jeffrey W. Anthis, David Thompson
  • Patent number: 10315996
    Abstract: Compounds according to Formula I: or a pharmaceutically acceptable salt wherein: A1 is NR1 or CR1, with R1 herein; the cyclopropyl moiety with one or more methyl and one or more F; A2-A5 are N or CR2-CR5, with no more than two of the four positions A in A2-A5 can be simultaneously N; R2-R5 are described; R6 and R7 are independently H, F, methyl, ethyl, hydroxyl or methoxy or R6 and R7 together is carbonyl, all alkyl groups, if substituted with one or more F; R8 is H or C(1-6)alkyl; A9-A12 are N or CR9-CR12, with no more than two of the four positions A in A9-A12 can be simultaneously N; R9-R12 herein; R13 and R14 herein; or R13 and R14 fused forming a ring having 5 to 7 atoms by joining R13 being C(1-6)alkyl or C(2-6)alkenyl. The ROR? compounds can treat ROR? mediated diseases.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: June 11, 2019
    Assignees: LEAD PHARMA HOLDING B.V., SANOFI
    Inventors: Joseph Maria Gerardus Barbara Cals, Vera De Kimpe, Sander Bernardus Nabuurs
  • Patent number: 10315997
    Abstract: A cyclopropyl unsaturated quinoline compound used as leukotriene receptor antagonist and applications thereof, wherein the structural formula of the compound is as follows: An application of the compound or its pharmaceutically acceptable salts, hydrates, solvates, or prodrugs in preparing a drug for treating and/or preventing and/or delaying and/or providing adjuvant therapy for asthma and/or allergic rhinitis and asthma syndromes is provided. A drug composition includes the cyclopropyl unsaturated quinoline compound or the pharmaceutically acceptable salts, hydrates, solvates, or prodrugs thereof. The compound series has favorable foreground in preparing the drugs for treating and/or preventing and/or delaying and/or providing adjuvant therapy for asthma and/or allergic rhinitis and asthma syndromes.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: June 11, 2019
    Assignee: GUANGDONG MOLTECH PHARMA CO., LTD.
    Inventor: Yingjie Lai
  • Patent number: 10315998
    Abstract: The present invention belongs to the field of fungicides, and relates to an amide compound and the preparation method and use thereof. The amide compound is as shown in general formula I: Each substituent in Formula I is defined in the description. The compound of general formula I of the present invention has an outstanding fungicidal activity, and can be used for controlling fungal diseases.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 11, 2019
    Assignee: SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.
    Inventors: Liang Lv, Gang Wang, Zhonggang Shan, Jiyong Liu, Qin Sun, Junfeng Wang, Bin Li
  • Patent number: 10315999
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: June 11, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Thomas Clark, Kaitlyn Gray, Belgin Canturk, Elisabeth J. Kane, Yu Zhang, Joseck M. Muhuhi
  • Patent number: 10316000
    Abstract: The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: June 11, 2019
    Assignee: Cornell University
    Inventors: Samie R. Jaffrey, Jeremy S. Paige
  • Patent number: 10316001
    Abstract: The present invention concerns a new and improved method for preparation of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluormethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I), as well as the preparation and use of the crystal form (A) of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluormethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I).
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: June 11, 2019
    Assignee: pH Pharma Co., Ltd.
    Inventors: Heiko Schirmer, Philipp Rubenbauer, Birgit Keil, Britta Olenik
  • Patent number: 10316002
    Abstract: The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: June 11, 2019
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Nathanael Gray, Hwan Geun Choi, Li Tan
  • Patent number: 10316003
    Abstract: Disclosed are a method of synthesizing prothioconazole and optically active isomers thereof and intermediates. The method includes reacting hydrazine with glyoxylic acid to produce a hydrazono acetic acid as an intermediate, and then reacting the intermediate with thiocyanate to produce the target product prothioconazole. The present method is very specific in terms of regioselectivity, resulting in minimum byproducts and a high product yield. The present method does not require special equipment, nor anhydrous or oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: June 11, 2019
    Assignee: ORIENTAL (LUZHOU) AGROCHEMICALS. CO., LTD.
    Inventors: Qiuju Sheng, Zhiming Zhang, Junliang Wang, Bangchi Chen
  • Patent number: 10316004
    Abstract: A process for preparing clomazone is provided, the process comprising reacting 4,4-dimethyl-3-isoxazolidinone with 2-chlorobenzyl chloride in an aqueous medium in the presence of a base, in particular an alkali metal hydroxide. A method for preparing clomazone is also disclosed, the method comprising (a) crystallizing clomazone from solution in an organic solvent; and (b) isolating the resulting crystals. N-benzene is a particularly suitable solvent. Further, there is provided Form I crystalline 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone (clomazone), wherein the polymorph Form I is characterized by at least one of the following properties: (i) an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2?(+/?0.20° ?) at one or more of the following positions: about 10.63, 16.07, 18.08, 19.11, 19.34, 21.20, 24.78 and 28.80; and (ii) an infrared (IR) spectrum having a characteristic peak: at about 2967 and 2870 cm?1.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: June 11, 2019
    Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED
    Inventor: James Timothy Bristow
  • Patent number: 10316005
    Abstract: The present invention relates to a process for the preparation of bis(dimercaptothiadiazole) (or bis-DMTD), more particularly of 5,5?-dithiobis(1,3,4-thiadiazole-2-thiol), said process being carried out in a single reactor and making possible a preparation with improved yields which is more respectful of the environment.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: June 11, 2019
    Assignee: MLPC INTERNATIONAL
    Inventors: Carole Coucharriere, Thierry Aubert, Dominique Bonhomme, Jean-Yves Ehlinger
  • Patent number: 10316006
    Abstract: An ionic liquid compound includes an azepanium-functionalized cation. An electrochemical cell electrolyte for an electrical energy storage device includes the ionic liquid compound, aprotic organic solvent, alkali metal salt and an additive.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: June 11, 2019
    Assignee: NOHMS Technologies, Inc.
    Inventors: Surya Moganty, Luigi Abbate, Gabriel Torres, Kevin Brown, John Sinicropi
  • Patent number: 10316007
    Abstract: A continuous process for preparing propylene oxide proceeds by (a) reacting propene with hydrogen peroxide in a reaction apparatus in the presence acetonitrile as solvent, obtaining a stream S0 containing propylene oxide, acetonitrile, water, at least one further component B; (b) separating propylene oxide from S0, obtaining stream S1 containing acetonitrile, water and B; (c) dividing S1 into streams S2 and S3; (d) subjects S3 to vapor-liquid fractionation in a first fractionation unit, obtaining vapor fraction stream S4a being depleted, relative to S3, of at least one of B and obtaining liquid bottoms stream S4b, and subjecting at least part of vapor fraction stream S4a to vapor-liquid fractionation in a second fractionation unit, obtaining vapor fraction stream S4c and liquid bottoms stream S4 being depleted, relative to S4a, of at least one of B; (e) recycling at least a portion of S4 to (a).
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: June 11, 2019
    Assignees: BASF SE, DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Joaquim Henrique Teles, Dominic Riedel, Bianca Seelig, Philip Kampe, Markus Weber, Alexander Schroeder, Andrei-Nicolae Parvulescu, Ulrich Mueller, Daniel Urbanczyk, Meinolf Weidenbach, Werner J. Witzl, Holger Baer
  • Patent number: 10316008
    Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 11, 2019
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
  • Patent number: 10316009
    Abstract: The invention relates generally to the preparation of hydroxymethyl furfural derivatives such as 5-carboxymethyl furfural derivatives, ethers such as 5-alkoxymethyl furfural derivatives, 5-hydroxymethyl furfural, levulinic acid, levulinic acid esters, and/or formic acid, formic acid esters from sugar.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 11, 2019
    Assignee: GFBIOCHEMICALS IP ASSETS B.V.
    Inventors: Brian D. Mullen, Cora M. Leibig, Roger Schoonover, Arie De Rijke, Kevin Jon Bechtold