Patents Issued in June 11, 2019
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Patent number: 10315960Abstract: A carbon fiber preform that includes a plurality of fibrous layers stacked together and a plurality of sacrificial fibers that bind the plurality of fibrous layers together, where at least one fibrous layer of the plurality of fibrous layers includes a plurality of carbon fibers or carbon fiber precursor fibers.Type: GrantFiled: October 5, 2016Date of Patent: June 11, 2019Assignee: Honeywell International Inc.Inventors: Mark L. La Forest, Slawomir T. Fryska, David M. Wright
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Patent number: 10315961Abstract: Provided herein is porous material which includes, as a framework of a porous structure, ZrO2 particles and a dissimilar material present on the surfaces of the ZrO2 particles. The dissimilar material includes at least one oxide selected from a first group of oxides and at least one oxide selected from a second group of oxides, or both. The first group of oxides includes, but is not limited to, SiO2, TiO2, La2O3, Al2O3, SrCO3, Gd2O3, Nb2O5, Y2O3, and a complex oxide including two or more of these oxides. The second group of oxides includes, but is not limited to, SiO2, TiO2, La2O3, Al2O3, SrCO3, Gd203, Nb2O5, Y2O3, and a complex oxide including two or more of the oxides, and ZrO2.Type: GrantFiled: May 20, 2016Date of Patent: June 11, 2019Assignee: NGK INSULATORS, LTD.Inventors: Takahiro Tomita, Hiroharu Kobayashi, Akinobu Oribe
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Patent number: 10315962Abstract: This disclosure relates to a semi-humic material, and compositions comprising the same, obtained from leonardite ore and a non-humic organic carbon source and a process for obtaining the same. Also described are methods for maintaining more available nitrogen and phosphorus in the plant root zone and minimizing premature leaching and loss of the nitrogen and/or phosphorus into the atmosphere, surface waters and/or subsurface ground water.Type: GrantFiled: October 27, 2017Date of Patent: June 11, 2019Assignee: Actagro, LLCInventors: Taha Rezai, John Breen, Thomas J. Gerecke, Qingwen He, Margaret Mae Abercrombie, Susan Her, Ryan Dierking, Gregory A. Crawford, Montell L. Bayer
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Patent number: 10315963Abstract: A composting facility includes: a floor for receiving compostable material thereon, wherein the floor is constructed above-grade; a dovetail extending from the floor to allow ingress of a vehicle from a grade level to the floor; one or more channels defined within the floor and extending through the dovetail; a covering extending over the one or more channels to maintain the compostable material away from the channel, the covering defining at least one aperture extending from above the covering into the one or more channels for allowing flowthrough of gases; and an air source for providing air through the channels to provide cooling characteristics to the compostable material or oxygen to aid an aerobic process associated with composting. In operation, liquids draining from the composting material pass through the at least one aperture into the channel and out through a portion of the channel extending through the dovetail.Type: GrantFiled: August 23, 2017Date of Patent: June 11, 2019Assignee: McGill Environmental Systems of N.C., Inc.Inventor: Michael Noel Lyons
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Patent number: 10315964Abstract: According to the present invention, a deuterium-substituted marker for fuel is synthesized through substitution with deuterium so as to have structurally and chemically similar properties to those of a molecule configuring fuel oil. A molecule of the deuterium-substituted marker is significantly similar to the conventional molecule configuring the fuel oil, which may prevent illegal removal of the marker by the fake oil manufacturers. According to the present invention, it is able to pursue public safety and environmental protection from fake oil products, and to prevent national tax evasion, by preventing the illegal mixing of fuel oil to secure a legal distribution of the oil market according to the present invention.Type: GrantFiled: November 9, 2016Date of Patent: June 11, 2019Assignee: Korea Institute of Petroleum ManagementInventors: Young-Kwan Lim, Hee-Yeon Baek, Kyoung-Heum Lee, Seung-Hyun Ryu, Ju Min Youn, Jong Ryeol Kim, In Ha Hwang, Jong Han Ha
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Patent number: 10315965Abstract: Systems and methods are presented that reduce energy and water consumption in processes for producing fuel from renewable alcohol-containing feedstreams. Alcohol content is converted directly to hydrocarbon transport fuels in a catalytic process, with heat transferred between intermediate process streams to reduce heat energy consumption. Overall water consumption is reduced by recovery of water from the catalytic process and reduction of water temperature to reduce evaporative losses.Type: GrantFiled: June 10, 2016Date of Patent: June 11, 2019Assignee: VERTIMASS LLCInventors: Charles E. Wyman, John R. Hannon
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Patent number: 10315966Abstract: Provided are fuel components, a method for producing fuel components, use of the fuel components and fuel containing the fuel components based on 5-nonanone.Type: GrantFiled: September 18, 2017Date of Patent: June 11, 2019Assignee: NESTE OYInventors: Jukka Myllyoja, Mats Käldström, Marina Lindblad, Jarno Kohonen, Maaria Seläntaus, Elias Ikonen
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Patent number: 10315967Abstract: Reactant materials for use in the synthesis of compounds comprising a non-metal and hydrogen, and methods of making and using the same are provided. The reactant materials generally comprise first and second non-metals, metals, a cation, and a transition metal, and can be formed and used in reactions occurring at relatively low-pressure conditions using heat energy that can be supplied via solar radiation. In particular, the reactant materials can be used in the synthesis of ammonia and various hydrocarbon compounds using air, water, and sunlight.Type: GrantFiled: November 25, 2013Date of Patent: June 11, 2019Assignee: Kansas State University Research FoundationInventors: Ronald Michalsky, Peter Pfromm
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Patent number: 10315968Abstract: A steam cracking process for converting hydrocarbons into smaller hydrocarbons, particularly olefins, in a tube reactor comprising a convection section, a cross-over section, and a radiant section. The process includes heating the fluid mixture inside the tube to a temperature at the end of the convection section where significant cracking occurs in the cross-over section. The high convection section and cross-over section temperatures allow for lower tube wall temperature in the radiant section resulting in less coke deposition on the inner wall of the tube, and hence extended run-lengths between adjacent decoking sessions.Type: GrantFiled: November 20, 2017Date of Patent: June 11, 2019Assignee: ExxonMobil Chemical Patents Inc.Inventors: Gary F. Janda, David B. Spicer
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Patent number: 10315969Abstract: Provided are a method of preparing a multicomponent bismuth-molybdenum composite metal oxide catalyst, and a multicomponent bismuth-molybdenum composite metal oxide catalyst prepared thereby. According to the preparation method, since the almost same structure as that of a typical quaternary bismuth-molybdenum catalyst may be obtained by performing two-step co-precipitation, i.e., primary and secondary co-precipitation, of metal components constituting the catalyst, the reduction of catalytic activity due to the deformation of the structure of the catalyst may be suppressed.Type: GrantFiled: June 4, 2015Date of Patent: June 11, 2019Assignee: LG CHEM, LTD.Inventors: Ye Seul Hwang, Dong Hyun Ko, Kyong Yong Cha, Dae Heung Choi, Myung Ji Suh, Jun Han Kang, Joo Hyuck Lee, Hyun Seok Nam, Jun Kyu Han, Sang Jin Han
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Patent number: 10315970Abstract: The present invention relates to a catalyst based on iron oxide for the dehydrogenation of hydrocarbons and also a process for producing it. The catalyst comprises at least one iron compound, at least one potassium compound and at least one cerium compound, wherein the at least one iron compound and the at least one potassium compound are at least partly present in the form of one or more K/Fe mixed oxide phases of the general formula KxFeyOz, where x is from 1 to 17; y is from 1 to 22 and z is from 2 to 34, where the catalyst comprises at least 20% by weight, based on the total catalyst, of the K/Fe mixed oxide phases and comprises crystalline cerium dioxide having a crystallite size in the range from 10 nm to 30 nm.Type: GrantFiled: May 6, 2015Date of Patent: June 11, 2019Assignee: BASF SEInventors: Florina C. Patcas, Bernd Hinrichsen, Martin Dieterle
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Patent number: 10315971Abstract: Systems and processes for heat recovery associated with the separation of hydrocarbon components. Two compressors are used to compress a portion of an overhead vapor stream from a fractionation column. A pressure of the liquid portion of the compressed overhead is reduced and used to recover heat from an overhead of another separation zone having a fractionation column. Once the heat has been recovered the stream is recompressed. The recovered heat may be removed from the recompressed stream in a reboiler of another fractionation column. The fractionation columns may comprise a deethanizer stripper, propane-propylene splitter, and a depropanizer column.Type: GrantFiled: November 15, 2017Date of Patent: June 11, 2019Assignee: UOP LLCInventors: Stephen T. King, Michael R. Van de Cotte, Adam J. Kanyuh, Steven C. Kozup
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Patent number: 10315972Abstract: The present invention relates to a separation method and a separation process system for easily recovering ethanol from an ethanol oligomerization reactant containing unreacted ethanol. A separation method according to the present invention may easily reflux ethylene while reducing or excluding the use of a reflux system which uses an expensive cooling medium, and the like, and thus may improve the economics while increasing separation efficiency.Type: GrantFiled: April 28, 2016Date of Patent: June 11, 2019Assignee: LG CHEM, LTD.Inventors: Hoi In Jeong, Jong Ku Lee, Jeong Seok Lee, Mi Kyung Kim
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Patent number: 10315973Abstract: This invention provides a method for preparing ethylene glycol by hydrolyzing ethylene glycol monomethyl ether.Type: GrantFiled: December 8, 2015Date of Patent: June 11, 2019Assignee: Dalian Institute of Chemical Physics, Chinese Academy of SciencesInventors: Youming Ni, Wenliang Zhu, Yong Liu, Hongchao Liu, Lei Shi, Zhongmin Liu
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Patent number: 10315974Abstract: [Object] It is intended to provide a crystalline maltitol powder less prone to consolidation, which is free from the formation of a lump during delivery or storage thereof, does not require pulverization or re-classification in use, is easy to handle in transfer, package opening, addition or mixing to another food material, and so on, and allows for automated transportation and so on. [Means for solving the object] The crystalline maltitol powder less prone to consolidation is obtained by charging crystalline or powdery maltitol into a shelf type dryer, a tunnel-type dryer, a cylindrical container, or the like and subjecting the equipment or container to a treatment wherein an air having a temperature of 30 to 33° C. and a relative humidity of 5% is allowed to flow into the equipment or container from one side thereof and withdrawn out of the other side thereof at a space velocity of 11 to 12 for consecutive 24 hours.Type: GrantFiled: December 9, 2015Date of Patent: June 11, 2019Assignee: MITSUBISHI SHOJI FOODTECH CO., LTD.Inventors: Chihaya Sano, Takashi Noguchi, Tohru Nemoto, Koshiro Shimazu
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Patent number: 10315975Abstract: The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.Type: GrantFiled: July 8, 2016Date of Patent: June 11, 2019Assignees: BASF SE, Ruprecht-Karls-Universität HeidelbergInventors: Julia Strautmann, Stefan Rüdenauer, Christian Rein, Melanie Weingarten, Rocco Paciello, Wolfgang Siegel, Michael Breuer, Peter Hofmann, Sebastian Schmidt
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Patent number: 10315976Abstract: 5,9-dimethyl-9-hydroxy-decen-4-al, having the formula (I)Type: GrantFiled: July 18, 2016Date of Patent: June 11, 2019Assignee: GIVAUDAN S.A.Inventors: Alain Alchenberger, Chloe Berbez, Clare Finn, Dominique Lelievre, Martin Alan Lovchik, Roseline Poignon-Martel, Gilles Romey
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Patent number: 10315977Abstract: The present invention relates to a method of preparing n-butyric acid by using poly-3-hydroxybutyrate. The method comprises following steps: placing poly-3-hydroxybutyrate in a closure means, passing hydrogen into the closure means to eliminate air after making an initial hydrogen pressure be 2 to 6 MPa, carrying out an agitation at 190 to 240° C. for reaction for 6 to 36 hours to obtain n-butyric acid. The preparation method provided by the present invention does not require a catalyst or a reaction solvent, and converts poly-3-hydroxybutyrate into n-butyric acid by a one-step reaction under a hydrogen atmosphere. The conversion rate of poly-3-hydroxybutyrate is 100%, the yield of n-butyric acid reaches up to 97%, the purity of n-butyric acid in all obtained liquid products reaches up to 98%, and no additional subsequent separation process is needed to the target product n-butyric acid.Type: GrantFiled: November 28, 2018Date of Patent: June 11, 2019Assignee: DONGGUAN UNIVERSITY OF TECHNOLOGYInventors: Shimin Kang, Hang Zhang, Jietai Li, Zhilin Li, Yongjun Xu, Chenghua Sun, Nanlong Hong
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Patent number: 10315978Abstract: A method of reducing the formation of an impurity in a terephthalic acid (TPA) production process includes: combining in a reactor, a catalyst, a mixture comprising the impurity and the TPA, and a compound comprising an active carbon atom; reacting the impurity with the compound in the presence of the catalyst by a condensation-dehydration reaction process comprising a nucleophilic addition of the active carbon atom of the compound to a carbonyl group of the impurity to form an intermediate followed by a dehydration reaction of the intermediate to form a product mixture comprising a water, the TPA, and an alkene; and recovering the product mixture from the reactor.Type: GrantFiled: November 14, 2016Date of Patent: June 11, 2019Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Nedumbamana Sankaran, Syed Azhar Hashmi, Vinodkumar Vasudevan
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Patent number: 10315979Abstract: Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from C6 and C5 sugars in the presence of a Lewis Acid material, wherein the yield of the 2,5,6-trihydroxy-3-hexenoic acid or 2,5-dihydroxy-3-pentenoic acid or esters thereof exceeds 15%.Type: GrantFiled: June 20, 2016Date of Patent: June 11, 2019Assignee: HALDOR TOPSØE A/SInventors: Esben Taarning, Irantzu Sadaba Zubiri, Sebastian Meier
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Patent number: 10315980Abstract: The present disclosure relates to a catalyst used in the preparation of acrylic acid and acrylic acid preparation method using the same, and more specifically, discloses a catalyst capable of enhancing selectivity of acrylic acid and a production yield of acrylic acid when preparing acrylic acid from allyl alcohol using a heterogeneous catalyst including bimetallic alloy catalyst particles of gold and another metal, and an acrylic acid preparation method using the same.Type: GrantFiled: August 24, 2016Date of Patent: June 11, 2019Assignee: LG CHEM, LTD.Inventors: Dongsu Song, Daesung Kim, Wonjae Lee, Yongjin Choe, Hyunjoo Lee, Minsu Kim
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Patent number: 10315981Abstract: A process for preparing a diaryl carbonate from a dialkyl carbonate and an aryl alcohol is disclosed. The process takes place in apparatus comprising at least two distillation columns, and at least one of the distillation columns is operated at subatmospheric pressure which is achieved using vacuum equipment.Type: GrantFiled: November 24, 2016Date of Patent: June 11, 2019Assignee: SHELL OIL COMPANYInventors: Kunquan Yu, Garo Garbis Vaporciyan
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Patent number: 10315982Abstract: The present invention relates to a composition comprising: a) at least one primary, secondary or tertiary amine and b) at least one agent which masks the odor of said at least one amine, said at least one odor-masking agent comprising at least one ether (b1), optionally, but preferably, at least one terpene and/or one terpenoid (b2) and optionally, but preferably, at least one oxime (b3). The invention also relates to the use of an odor-masking agent in order to mask the odor of at least one amine.Type: GrantFiled: February 3, 2015Date of Patent: June 11, 2019Assignee: ARKEMA FRANCEInventors: Christophe Ruppin, Christian Forquy
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Patent number: 10315983Abstract: The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a hydrohydroxymethylation reaction.Type: GrantFiled: February 9, 2016Date of Patent: June 11, 2019Assignees: PIVERT S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'ARTOISInventors: Frederic Hapiot, Eric Monflier, Theodore Vanbesien
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Patent number: 10315984Abstract: In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.Type: GrantFiled: December 15, 2017Date of Patent: June 11, 2019Assignee: THERAVANCE BIOPHARMA R&D IP, LLCInventors: Melissa Fleury, Adam D. Hughes
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Patent number: 10315985Abstract: The invention provides a bio-based acrylic monomer, particularly a plant oil-based acrylic monomer, which is well-suited for emulsion polymerization and latex formation in aqueous medium. Polymers and copolymers formed from the bio-based acrylic monomer are also provided. The invention further provided methods for making the monomer from bio-based triglycerides or fatty esters.Type: GrantFiled: August 7, 2015Date of Patent: June 11, 2019Assignee: NDSU RESEARCH FOUNDATIONInventors: Andriy Voronov, Ihor Tarnavchyk
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Patent number: 10315986Abstract: A method for forming a solution of ammonium carbamate is provided herein. The method includes, but is not limited to, providing a reactor comprising a solution of ammonia. The method further includes, but is not limited to, feeding carbon dioxide through the solution of ammonia to form a mixture. The method further includes, but is not limited to, combining a solution of sodium hydroxide and the mixture to form the ammonium carbamate.Type: GrantFiled: April 6, 2018Date of Patent: June 11, 2019Assignee: SOLENIS TECHNOLOGIES, L.P.Inventors: Cecil Coutinho, Michael Mitchell, Stephen Vinciguerra
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Patent number: 10315987Abstract: Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.Type: GrantFiled: December 9, 2011Date of Patent: June 11, 2019Assignee: Surmodics, Inc.Inventor: Aleksey V. Kurdyumov
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Patent number: 10315988Abstract: Methods of making an alpha-olefin sulfonic dimer acid (AOS dimer acid) are disclosed. In one method, an alpha-olefin is sulfonated, preferably with sulfur trioxide, to produce a mixture comprising an alpha-olefin sulfonic acid (AOS acid) and sulfur dioxide. This mixture is then heated while purging sulfur dioxide and hydrogen sulfide from the reactor to produce an AOS dimer acid composition. In another method, the AOS acid mixture is treated to remove sulfur dioxide and is then heated to produce an AOS dimer acid composition. With either method, the resulting AOS dimer acid composition has at least a 30% decrease in the level of elemental sulfur when compared with that of an AOS dimer acid composition prepared by a similar process in the absence of any active removal of sulfur dioxide or hydrogen sulfide. AOS dimer acid compositions and salts of the AOS dimer acids, which are useful surfactants for oilfield and other applications, are also disclosed.Type: GrantFiled: July 28, 2016Date of Patent: June 11, 2019Assignee: STEPAN COMPANYInventors: Gregory P. Dado, Aaron Sanders, Xue Min Dong, E. Carolina Rojas
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Patent number: 10315989Abstract: The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to compositions comprising these compounds.Type: GrantFiled: February 18, 2015Date of Patent: June 11, 2019Assignee: MERCK PATENT GMBHInventors: Reiner Friedrich, Fanny Schooren
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Patent number: 10315990Abstract: The present invention provides an isothiocyanate compound and its application. The compound is an aryl-substituted isothiocyanate compound that has a structure of the general formula I. The isothiocyanate compound of the present invention has very good solubility in water, far better inhibitory activity for XPO1 protein than other non-aryl substituted congeneric compounds, little side effects, and good biological safety and bioavailability, and is quite suitable for clinical application. Therefore, the isothiocyanate compound would have tremendous potential market space and economic benefits.Type: GrantFiled: February 3, 2016Date of Patent: June 11, 2019Assignee: DRIVINGFORCE THERAPEUTICSInventor: Yongliang Yang
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Patent number: 10315991Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.Type: GrantFiled: August 28, 2017Date of Patent: June 11, 2019Assignee: Global Blood Therapeutics, Inc.Inventors: Qing Xu, Zhe Li
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Patent number: 10315992Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.Type: GrantFiled: January 6, 2017Date of Patent: June 11, 2019Assignee: Tetraphase Pharmaceuticals, Inc.Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
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Patent number: 10315993Abstract: The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.Type: GrantFiled: April 25, 2018Date of Patent: June 11, 2019Assignee: Cadila Healthcare LimitedInventors: Mukul R. Jain, Suresh Giri, Himanshu M. Kothari, Kaushik Banerjee, Rashmikant Kachhiya
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Patent number: 10315994Abstract: The present invention describes compounds and uses thereof in applications relating to absorption of electromagnetic energy. Preferred compounds are double bond-containing cyclic compounds capable of absorbing electromagnetic radiation energy and having improved photostability due to the presence and location of one or more fluorine groups in relation to the double bond of the ring.Type: GrantFiled: November 28, 2016Date of Patent: June 11, 2019Assignee: Commomwealth Scientific and Industrial Research OrganizationInventors: John Ryan, Mark York
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Patent number: 10315995Abstract: Methods for deposition of elemental metal films on surfaces using metal coordination complexes comprising nitrogen-containing ligands are provided. Also provided are nitrogen-containing ligands useful in the methods of the invention and metal coordination complexes comprising these ligands.Type: GrantFiled: January 17, 2017Date of Patent: June 11, 2019Assignee: Applied Materials, Inc.Inventors: Jeffrey W. Anthis, David Thompson
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Patent number: 10315996Abstract: Compounds according to Formula I: or a pharmaceutically acceptable salt wherein: A1 is NR1 or CR1, with R1 herein; the cyclopropyl moiety with one or more methyl and one or more F; A2-A5 are N or CR2-CR5, with no more than two of the four positions A in A2-A5 can be simultaneously N; R2-R5 are described; R6 and R7 are independently H, F, methyl, ethyl, hydroxyl or methoxy or R6 and R7 together is carbonyl, all alkyl groups, if substituted with one or more F; R8 is H or C(1-6)alkyl; A9-A12 are N or CR9-CR12, with no more than two of the four positions A in A9-A12 can be simultaneously N; R9-R12 herein; R13 and R14 herein; or R13 and R14 fused forming a ring having 5 to 7 atoms by joining R13 being C(1-6)alkyl or C(2-6)alkenyl. The ROR? compounds can treat ROR? mediated diseases.Type: GrantFiled: June 3, 2016Date of Patent: June 11, 2019Assignees: LEAD PHARMA HOLDING B.V., SANOFIInventors: Joseph Maria Gerardus Barbara Cals, Vera De Kimpe, Sander Bernardus Nabuurs
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Patent number: 10315997Abstract: A cyclopropyl unsaturated quinoline compound used as leukotriene receptor antagonist and applications thereof, wherein the structural formula of the compound is as follows: An application of the compound or its pharmaceutically acceptable salts, hydrates, solvates, or prodrugs in preparing a drug for treating and/or preventing and/or delaying and/or providing adjuvant therapy for asthma and/or allergic rhinitis and asthma syndromes is provided. A drug composition includes the cyclopropyl unsaturated quinoline compound or the pharmaceutically acceptable salts, hydrates, solvates, or prodrugs thereof. The compound series has favorable foreground in preparing the drugs for treating and/or preventing and/or delaying and/or providing adjuvant therapy for asthma and/or allergic rhinitis and asthma syndromes.Type: GrantFiled: September 10, 2015Date of Patent: June 11, 2019Assignee: GUANGDONG MOLTECH PHARMA CO., LTD.Inventor: Yingjie Lai
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Patent number: 10315998Abstract: The present invention belongs to the field of fungicides, and relates to an amide compound and the preparation method and use thereof. The amide compound is as shown in general formula I: Each substituent in Formula I is defined in the description. The compound of general formula I of the present invention has an outstanding fungicidal activity, and can be used for controlling fungal diseases.Type: GrantFiled: May 4, 2016Date of Patent: June 11, 2019Assignee: SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.Inventors: Liang Lv, Gang Wang, Zhonggang Shan, Jiyong Liu, Qin Sun, Junfeng Wang, Bin Li
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Patent number: 10315999Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.Type: GrantFiled: May 8, 2018Date of Patent: June 11, 2019Assignee: Dow AgroSciences LLCInventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Thomas Clark, Kaitlyn Gray, Belgin Canturk, Elisabeth J. Kane, Yu Zhang, Joseck M. Muhuhi
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Patent number: 10316000Abstract: The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.Type: GrantFiled: February 18, 2010Date of Patent: June 11, 2019Assignee: Cornell UniversityInventors: Samie R. Jaffrey, Jeremy S. Paige
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Patent number: 10316001Abstract: The present invention concerns a new and improved method for preparation of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluormethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I), as well as the preparation and use of the crystal form (A) of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluormethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I).Type: GrantFiled: March 15, 2016Date of Patent: June 11, 2019Assignee: pH Pharma Co., Ltd.Inventors: Heiko Schirmer, Philipp Rubenbauer, Birgit Keil, Britta Olenik
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Patent number: 10316002Abstract: The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.Type: GrantFiled: September 6, 2017Date of Patent: June 11, 2019Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Nathanael Gray, Hwan Geun Choi, Li Tan
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Patent number: 10316003Abstract: Disclosed are a method of synthesizing prothioconazole and optically active isomers thereof and intermediates. The method includes reacting hydrazine with glyoxylic acid to produce a hydrazono acetic acid as an intermediate, and then reacting the intermediate with thiocyanate to produce the target product prothioconazole. The present method is very specific in terms of regioselectivity, resulting in minimum byproducts and a high product yield. The present method does not require special equipment, nor anhydrous or oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.Type: GrantFiled: December 28, 2018Date of Patent: June 11, 2019Assignee: ORIENTAL (LUZHOU) AGROCHEMICALS. CO., LTD.Inventors: Qiuju Sheng, Zhiming Zhang, Junliang Wang, Bangchi Chen
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Patent number: 10316004Abstract: A process for preparing clomazone is provided, the process comprising reacting 4,4-dimethyl-3-isoxazolidinone with 2-chlorobenzyl chloride in an aqueous medium in the presence of a base, in particular an alkali metal hydroxide. A method for preparing clomazone is also disclosed, the method comprising (a) crystallizing clomazone from solution in an organic solvent; and (b) isolating the resulting crystals. N-benzene is a particularly suitable solvent. Further, there is provided Form I crystalline 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone (clomazone), wherein the polymorph Form I is characterized by at least one of the following properties: (i) an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2?(+/?0.20° ?) at one or more of the following positions: about 10.63, 16.07, 18.08, 19.11, 19.34, 21.20, 24.78 and 28.80; and (ii) an infrared (IR) spectrum having a characteristic peak: at about 2967 and 2870 cm?1.Type: GrantFiled: June 13, 2014Date of Patent: June 11, 2019Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITEDInventor: James Timothy Bristow
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Patent number: 10316005Abstract: The present invention relates to a process for the preparation of bis(dimercaptothiadiazole) (or bis-DMTD), more particularly of 5,5?-dithiobis(1,3,4-thiadiazole-2-thiol), said process being carried out in a single reactor and making possible a preparation with improved yields which is more respectful of the environment.Type: GrantFiled: July 1, 2010Date of Patent: June 11, 2019Assignee: MLPC INTERNATIONALInventors: Carole Coucharriere, Thierry Aubert, Dominique Bonhomme, Jean-Yves Ehlinger
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Patent number: 10316006Abstract: An ionic liquid compound includes an azepanium-functionalized cation. An electrochemical cell electrolyte for an electrical energy storage device includes the ionic liquid compound, aprotic organic solvent, alkali metal salt and an additive.Type: GrantFiled: April 21, 2017Date of Patent: June 11, 2019Assignee: NOHMS Technologies, Inc.Inventors: Surya Moganty, Luigi Abbate, Gabriel Torres, Kevin Brown, John Sinicropi
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Patent number: 10316007Abstract: A continuous process for preparing propylene oxide proceeds by (a) reacting propene with hydrogen peroxide in a reaction apparatus in the presence acetonitrile as solvent, obtaining a stream S0 containing propylene oxide, acetonitrile, water, at least one further component B; (b) separating propylene oxide from S0, obtaining stream S1 containing acetonitrile, water and B; (c) dividing S1 into streams S2 and S3; (d) subjects S3 to vapor-liquid fractionation in a first fractionation unit, obtaining vapor fraction stream S4a being depleted, relative to S3, of at least one of B and obtaining liquid bottoms stream S4b, and subjecting at least part of vapor fraction stream S4a to vapor-liquid fractionation in a second fractionation unit, obtaining vapor fraction stream S4c and liquid bottoms stream S4 being depleted, relative to S4a, of at least one of B; (e) recycling at least a portion of S4 to (a).Type: GrantFiled: October 27, 2015Date of Patent: June 11, 2019Assignees: BASF SE, DOW GLOBAL TECHNOLOGIES LLCInventors: Joaquim Henrique Teles, Dominic Riedel, Bianca Seelig, Philip Kampe, Markus Weber, Alexander Schroeder, Andrei-Nicolae Parvulescu, Ulrich Mueller, Daniel Urbanczyk, Meinolf Weidenbach, Werner J. Witzl, Holger Baer
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Patent number: 10316008Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.Type: GrantFiled: January 12, 2018Date of Patent: June 11, 2019Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
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Patent number: 10316009Abstract: The invention relates generally to the preparation of hydroxymethyl furfural derivatives such as 5-carboxymethyl furfural derivatives, ethers such as 5-alkoxymethyl furfural derivatives, 5-hydroxymethyl furfural, levulinic acid, levulinic acid esters, and/or formic acid, formic acid esters from sugar.Type: GrantFiled: August 19, 2016Date of Patent: June 11, 2019Assignee: GFBIOCHEMICALS IP ASSETS B.V.Inventors: Brian D. Mullen, Cora M. Leibig, Roger Schoonover, Arie De Rijke, Kevin Jon Bechtold