Patents Issued in July 2, 2019
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Patent number: 10336652Abstract: The present invention discloses cementitious compositions which contain hydratable cement, limestone, or mixture thereof, having improved strength properties due to the presence of calcined clay and certain higher alkanolamines, wherein the calcined clay has an Fe2O3 content of greater than one percent (1%). Also disclosed are exemplary additives and methods for enhancing strength of cement and/or limestone compositions.Type: GrantFiled: November 10, 2017Date of Patent: July 2, 2019Assignee: GCP Applied Technologies Inc.Inventors: Elise Berodier, Josephine H. Cheung, Nathan A. Tregger
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Patent number: 10336653Abstract: A refractory object may include a Cr2O3 content of at least about 80 wt. % of a total weight of the refractory object, an Al2O3 content of at least about 0.7 wt. % and not greater than about 10.0 wt. % of the total weight of the refractory object, a SiO2 content of at least about 0.3 wt. % and not greater than about 5.0 wt. % of the total weight of the refractory object and a TiO2 content of at least about 1.0 wt. % and not greater than about 5.6 wt. % TiO2 of the total weight of the refractory object. The refractory object may further include an MOR of at least about 37 MPa as measured at 1200° C.Type: GrantFiled: February 2, 2017Date of Patent: July 2, 2019Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.Inventors: Kristen E. Pappacena, Julien P. Fourcade
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Patent number: 10336654Abstract: In one aspect, sintered cemented carbide compositions are described herein exhibiting desirable wear resistance without deleterious losses in fracture toughness. Such cemented carbide compositions can be employed as tooling in a variety of applications including earth boring and mining operations as well as machining various metals and alloys. For example, a sintered cemented carbide composition described herein comprises a hard particle phase including tungsten carbide and a cobalt-based metallic binder comprising a cubic cobalt-molybdenum solid solution phase.Type: GrantFiled: August 28, 2015Date of Patent: July 2, 2019Assignee: KENNAMETAL INC.Inventor: Oladapo Eso
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Patent number: 10336655Abstract: A process is provided for producing shaped bodies including carbon fiber reinforced carbon in which the fibers are present in the form of bundles having a defined length, width and thickness. The defined configuration of the fibers in the bundles allows a targeted configuration of the reinforcing fibers in the carbon matrix and thus a structure of the reinforcement which matches the stress of shaped bodies including carbon fiber reinforced carbon, for example brake disks.Type: GrantFiled: September 28, 2016Date of Patent: July 2, 2019Assignee: SGL Carbon SEInventors: Andreas Kienzle, Ingrid Kraetschmer
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Patent number: 10336656Abstract: A machined ceramic article having an initial surface defect density and an initial surface roughness is provided. The machined ceramic article is heated to a temperature range between about 1000° C. and about 1800° C. at a ramping rate of about 0.1° C. per minute to about 20° C. per minute. The machined ceramic article is heat-treated in air atmosphere. The machined ceramic article is heat treated at one or more temperatures within the temperature range for a duration of up to about 24 hours. The machined ceramic article is then cooled at the ramping rate, wherein after the heat treatment the machined ceramic article has a reduced surface defect density and a reduced surface roughness.Type: GrantFiled: April 15, 2015Date of Patent: July 2, 2019Assignee: APPLIED MATERIALS, INC.Inventors: Ren-Guan Duan, Thorsten Lill, Jennifer Y. Sun, Benjamin Schwarz
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Patent number: 10336657Abstract: A composition that may be used to retain moisture within fresh concrete as it cures to optimize the curing of the concrete may include one or more hardening and densifying agents (e.g., alkali metal polysilicate, colloidal silica, etc.) and one or more temporary moisture sealing agents (e.g., a wax, etc.). Additionally, such a composition may include a siliconate (e.g., a metal siliconate, such as an alkali metal siliconate like potassium methyl siliconate, etc.). The hardening and densifying agent of such a composition may penetrate the surface of fresh concrete to react with free lime, providing the fresh concrete with a strong surface. The temporary moisture sealing agent may form a moisture barrier on the surface of the fresh concrete to prevent moisture from escaping from the fresh concrete (e.g., evaporating, etc.) before the fresh concrete has sufficiently cured. The temporary moisture sealing agent may degrade within a matter of days (e.g., three days, seven days, 14 days, less than a month, etc.Type: GrantFiled: March 13, 2018Date of Patent: July 2, 2019Assignee: Advanced Concrete Technologies LLCInventors: Dal N. Hills, Kent Barrus
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Patent number: 10336658Abstract: A pull mat for tunnel composting includes: a layer of straight unidirectionally oriented threads oriented in the longitudinal direction of the pull mat, the layer including a multitude of straight individual threads which are placed essentially parallel to each other in a single plane, the straight unidirectionally oriented threads being spaced apart from each other, at least one layer of open material, the at least one layer of open material being selected from a woven fabric, a laid scrim, a nonwoven fabric, and a perforated film, and optionally, a further layer of open material, wherein when the optional further layer of open material is present, the at least one layer of open material and the further layer of open material are positioned on opposite sides of the layer of straight, unidirectionally oriented threads.Type: GrantFiled: April 30, 2014Date of Patent: July 2, 2019Assignee: IFG EXELTO NVInventors: Ives Swennen, Kris Coen, Tim Parrein
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Patent number: 10336659Abstract: Improved agriculturally useful products are provided, including solid materials such as nitrogenous fertilizers (e.g., urea), together with a polycarboxylated polymer selected from the group consisting of a salts of copolymers containing individual quantities of maleic and itaconic moieties. The polymer composition also includes from about 10-60% by weight of an organic drying agent such as a lower alcohol which enhances the quick drying properties thereof. The compositions may also include an amount of boron, and bimodal vinylic polymer made up of quantities of high and low molecular weight (MW) vinylic polymers such as PVA.Type: GrantFiled: December 17, 2015Date of Patent: July 2, 2019Assignee: VERDESIAN LIFE SCIENCES, LLCInventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
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Patent number: 10336660Abstract: An inhibitor composition contains alkyl thiophosphoric triamide (or a mixture of alkyl thiophosphoric triamide and dicyandiamide), dissolved in a liquid medium comprising at least one organic solvent, at least one amine stabilizer and, optionally, at least one dye and/or at least one odor masking agent, is useful in making fertilizer compositions and in a method of fertilizing target plants.Type: GrantFiled: June 29, 2017Date of Patent: July 2, 2019Assignee: RHODIA OPERATIONSInventors: Hong Liu, Jiamin Wu, Andre Gomes, Krish Shanmuga, Zhiyun Chen
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Patent number: 10336661Abstract: An energetic nanocomposite includes fuel nanoparticles and oxidizer nanoparticles covalently bonded to negatively charged functionalized graphene sheets. A preferred example includes Al fuel nanoparticles and Bi2O3 nanoparticles. A preferred method of formation mixes a solution of positively charged fuel nanoparticles, positively charged oxidizer nanoparticles, and negatively charged functionalized graphene sheets having functional groups to bond with the positively charged fuel nanoparticles and positively charged oxidizer nanoparticles. Self-assembly of the energetic nanocomposite is permitted over a predetermined time via the attraction and aggregation of the positively charged fuel nanoparticles positively charged oxidizer nanoparticles and negatively charged functionalized graphene sheets. Additional methods and nanocomposites include unfunctionalized graphene sheets, which can be commercial grade sheets.Type: GrantFiled: August 4, 2014Date of Patent: July 2, 2019Assignee: The Curators of the University of MissouriInventors: Shubhra Gangopadhyay, Stephen W. Chung, Rajagopalan Thiruvengadathan, Clay Stephen Staley, Keshab Gangopadhyay, Kristofer Emile Raymond
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Patent number: 10336662Abstract: The invention is an article of manufacture, a composition of matter and an in-situ process for making non-hygroscopic ammonium nitrate prills. The non-hygroscopic prills are formed from dried prills of ammonium nitrate, in reaction vessel having an inert gas atmosphere and a nonpolar reaction diluent. A shell is formed in situ by reacting a first reactant with a second reactant in the presence of the AN prills en masse. The prills, en masse, are individually sealed in the shell made of a highly crosslinked polymeric material. The material is a reaction product of a diglycidyl hydantoin and a polyoxypropylene-triamine.Type: GrantFiled: September 26, 2016Date of Patent: July 2, 2019Assignee: The United States of America as represented by the Secretary of the NavyInventors: Joseph D Mannion, John P Consaga
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Patent number: 10336663Abstract: The present invention discloses processes for oligomerizing an olefin feedstock containing C4 to C20 alpha olefins using a catalyst system containing a metallocene compound, an organoaluminum compound, and a suspension of a chemically-treated solid oxide. The liquid medium for the suspension of the chemically-treated solid oxide can be an alpha-olefin oligomer product formed by the oligomerization process.Type: GrantFiled: September 12, 2017Date of Patent: July 2, 2019Assignee: Chevron Phillips Chemical Company LPInventors: Graham R. Lief, Eric J. Haschke, Pasquale Iacono
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Patent number: 10336664Abstract: Fluidizable catalysts for the gas phase oxygen-free oxidative cracking of alkanes, such as hexane, to one or more olefins, such as ethylene, propylene, and/or butylene. The catalysts comprise 1-15% by weight per total catalyst weight of one or more vanadium oxides (VOx), such as V2O5. The catalysts are disposed on an alumina support that is modified with cerium to influence catalyst acidity and characteristics of lattice oxygen at the catalyst surface. Various methods of preparing and characterizing the catalyst as well as methods for the gas phase oxygen free oxidative cracking of alkanes, such as hexane, to one or more olefins, such as ethylene, propylene, and/or butylene with improved alkane conversion and olefins product selectivity are also disclosed.Type: GrantFiled: July 13, 2018Date of Patent: July 2, 2019Assignee: King Fahd University of Petroleum and MineralsInventors: Mohammad Mozahar Hossain, AbdAlwadood Hassan Elbadawi, Muhammad Yasir Khan, Shaikh Abdur Razzak
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Patent number: 10336665Abstract: A process for the production of para-xylene is presented. The process includes the isomerization of C8 aromatics to para-xylene utilizing a new catalyst. The new catalyst is a layer MFI zeolite and is represented by the empirical composition in the as synthesized and anhydrous basis expressed by the empirical formula of: Mmn+Rrp+AlSiyOz where M is at least one exchangeable cation selected from the group consisting of alkali and alkaline earth metals and R is at least one organoammonium cation.Type: GrantFiled: March 3, 2015Date of Patent: July 2, 2019Assignee: UOP LLCInventors: Gregory B. Kuzmanich, Jaime G. Moscoso, Deng-Yang Jan
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Patent number: 10336666Abstract: Processes for catalytic dehydrogenation of paraffin stream is disclosed. The process includes passing a first portion of the paraffin-containing feedstream through a select catalytic reactor in a plurality of catalytic reactors. An internal differential pressure is measured in the select catalytic reactor. A second portion of the paraffin-containing feed stream is bypassed around the select catalytic reactor when the measured internal differential pressure is above a predetermined limit of the internal differential pressure. The bypassed second portion is passed to at least one other catalytic reactor in the plurality of reactors located downstream of the select catalytic reactor being bypassed.Type: GrantFiled: August 9, 2017Date of Patent: July 2, 2019Assignee: UOP LLCInventor: Gary A. Dziabis
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Patent number: 10336667Abstract: The present invention relates to a catalyst for the dehydrogenation of hydrocarbons which is based on iron oxide and a process for producing it. The catalyst comprises at least one iron compound, at least one potassium compound and from 11 to 24% by weight of at least one cerium compound, calculated as CeO2, wherein the at least one iron compound and the at least one potassium compound are at least partly present in the form of one or more K/Fe mixed oxide phases of the general formula KxFeyOz, where x is from 1 to 17; y is from 1 to 22 and z is from 2 to 34, and comprises at least 50% by weight, based on the total catalyst, of the K/Fe mixed oxide phases, and also a process for producing it.Type: GrantFiled: May 6, 2015Date of Patent: July 2, 2019Assignee: BASF SEInventors: Florina C. Patcas, Martin Dieterle
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Patent number: 10336668Abstract: A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture.Type: GrantFiled: November 18, 2015Date of Patent: July 2, 2019Assignee: BASF SEInventors: Jan-Oliver Weidert, Sandra Kramp, Regina Benfer, Alexander Panchenko, Andreas Weickgenannt, Norbert Gutfrucht, Klaus Breuer, Artur Kozicki, Ralph Busch
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Patent number: 10336669Abstract: The present invention relates to a method for preparing hexafluorobutadiene comprising the following steps: (a) hydrodechlorinating hexachlorobutadiene to form a first stream comprising 1,2,3,4-tetrachlorobutadiene and optionally unreacted hexachlorobutadiene; (b) fluorinating the first stream comprising 1,2,3,4-tetrachlorobutadiene obtained in step (a) to form a second stream comprising 1,1,2,3,4,4-hexafluorobutane, (c) dehydrogenating the second stream comprising 1,1,2,3,4,4-hexafluorobutane to form a third stream comprising hexafluorobutadiene.Type: GrantFiled: March 20, 2017Date of Patent: July 2, 2019Assignee: ARKEMA FRANCEInventors: Grégory Schmidt, Rémy Teissier
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Patent number: 10336670Abstract: The invention relates to the field of petrochemistry, and specifically to a method for synthesizing high-octane oxygen containing components of motor fuel. The objects of the invention consist in variants of a method for synthesizing high-octane oxygen-containing components of motor fuel from olefin-containing gas mixtures via oxidative non-catalytic conversions using nitrous oxide, and the subsequent condensation and hydrogenation of the produced oxygenates using heterogeneous catalysts. The high-octane components according to the proposed method consist in a mixture of carbonyl compounds (ketones, aldehydes, hydroxy ketones, hydroxy aldehydes) C2-C9 and/or branched hydrocarbons C5-C9 and/or alcohols in different ratios. Depending on the production method variant, the octane number of a mixture of the proposed high-octane components consists in a value between 100 and 130 RON.Type: GrantFiled: November 29, 2016Date of Patent: July 2, 2019Assignee: Aktsionernoe Obschestvo “Gazpromneft—Moskovsky NPZ” (AO Gazpromneft-MNPZ)Inventors: Aleksandr Sergeevich Haritonov, Konstantin Aleksandrovich Dubkov, Mihail Vladimirovich Parfenov, Aleskandr Stepanovich Noskov, Valery Aleksandrovich Golovachev, Andrei Vladimirovich Kleimenov, Dmitry Olegovich Kondrashev, Valentina Dmitrievna Miroshkina, Dmitrii Petrovich Ivanov, Sergey Vladimirovich Semikolenov, Valery Sergeevich Chernyavsky, Larisa Vladimirovna Piryutko, Kristina Andreevna Rusetskaya, Sergey Evgenyevich Kuznetsov
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Patent number: 10336671Abstract: A process for recovering a metallic component from a hydrocarbon product stream is disclosed. The hydrocarbon product stream is subjected to a thermal oxidation. A process for preparing glycols from a saccharide-containing feedstock is additionally disclosed.Type: GrantFiled: September 5, 2016Date of Patent: July 2, 2019Assignee: SHELL OIL COMPANYInventors: Hendrik Albertus Colijn, Dionysius Jacobus Maria De Vlieger
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Patent number: 10336672Abstract: The present invention describes a process for production of neopentyl glycol (NPG) from formaldehyde (FD) and isobutyraldehyde (IBD). FD and IBD first react to form hydroxypivaldehyde (HPD) in an aldol condensation step, then HPD is hydrogenated to form NPG in a hydrogenation step. The aldol condensation step is performed using a solid catalyst such as an ion exchange resin catalyst, which can be easily separated from the reaction product. The feed to the aldol condensation step is made homogeneous by adjusting the ratio of IBD, FD, and water in the feed or by adding a solvent that is miscible with both IBD and water. High purity NPG is recovered from the product of the hydrogenation step by a suitable method such as crystallization.Type: GrantFiled: August 3, 2015Date of Patent: July 2, 2019Assignees: ClearWaterBay Technology, Inc., ClearWaterBay Technology, Ltd.Inventors: Drow Lionel O'Young, Christianto Wibowo, Yik Chung Chan
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Patent number: 10336673Abstract: The present application relates to a process for production of hydrocarbons comprising the steps of converting a feed stream comprising alcohols, ethers or mixtures hereof over a metal-containing zeolite based catalyst, active in dehydrogenation of hydrocarbons, in a conversion step thereby obtaining a conversion effluent, separating said effluent to obtain an aqueous process condensate stream, a liquid hydrocarbon stream and a gaseous stream, removing part of the hydrogen formed in the conversion step, and recycling at least part of the gaseous and/or liquid hydrocarbon stream to the conversion step.Type: GrantFiled: January 22, 2016Date of Patent: July 2, 2019Assignee: HALDOR TOPSØE A/SInventors: Finn Joensen, Uffe Vie Mentzel, Ian Menjon
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Patent number: 10336674Abstract: The present disclosure relates to chemical synthesis. Various embodiments of the teachings thereof may include the synthesis of methanol, generated from hydrogen and a carbonaceous gas. For example, a method may include: compressing gaseous starting materials to an operating pressure of at least 200 bar; supplying the starting materials to a synthesis reactor; removing a product mixture from the synthesis reactor in a liquid state; withdrawing mechanical energy from the product mixture by reducing a pressure of the product mixture; and using the mechanical energy to compress the gaseous starting materials.Type: GrantFiled: July 27, 2016Date of Patent: July 2, 2019Assignee: SIEMENS AKTIENGESELLSCHAFTInventor: Alexander Tremel
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Patent number: 10336675Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.Type: GrantFiled: December 14, 2016Date of Patent: July 2, 2019Assignee: DSM IP ASSETS B.V.Inventors: Igor Bendik, Piero Geotti-Bianchini, Marc Heidl, Eileen Jackson, Alexander Schlifke-Poschalko
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Patent number: 10336676Abstract: The present invention pertains to novel (alkoxymethylene)octahydro-1H-4,7-methanoindene compounds and their unexpected advantageous use thereof in enhancing, improving or modifying the fragrance of perfumes, colognes, toilet waters, fabric care products, personal products, and the like.Type: GrantFiled: September 12, 2018Date of Patent: July 2, 2019Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Nicole Giffin, Michael G. Monteleone
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Patent number: 10336677Abstract: The present invention relates to a process for the purification of curcumin comprising provision of a curcuminoid composition, contacting said curcuminoid composition with basic amino acid or amino acid ester in order to form an amino acid salt of curcumin, separating the salt of curcumin, and recovering curcumin at increased purity levels. Curcumin may be obtained at purity levels beyond 90 wt. %.Type: GrantFiled: March 16, 2017Date of Patent: July 2, 2019Assignee: BIOPTEQ SPRLInventor: Philippe Neven
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Patent number: 10336678Abstract: The present disclosure provides methods for enantioselective synthesis of acyclic ?-quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation.Type: GrantFiled: May 11, 2018Date of Patent: July 2, 2019Assignee: California Institute of TechnologyInventors: Samantha E. Shockley, John C. Hethcox, Brian M. Stoltz
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Patent number: 10336679Abstract: The present disclosure provides polymorphic forms of sodium benzoate with a X-ray diffraction pattern comprising characteristic peaks at a reflection angle 2? of approximately 5.9, 30.2, and 31.2 degrees; or a X-ray diffraction pattern comprising characteristic peaks at a reflection angle 2? of approximately 3.7, 5.9, and 26.6 degrees. Also provided herein are methods of preparing the polymorphic forms of sodium benzoate and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, or Alzheimer's disease).Type: GrantFiled: March 7, 2017Date of Patent: July 2, 2019Assignee: SyneuRx International (Taiwan) Corp.Inventors: Guochuan Emil Tsai, Ching-Cheng Wang, Tien-Lan Hsieh
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Patent number: 10336680Abstract: A process for preparing bis(2-hydroxyethyl) terephthalate, comprising a step of: subjecting ethylene oxide and terephthalic acid in a molar ratio of from 2:1 to 3:1 to a reaction at an elevated temperature in the presence of a solvent mixture containing water and a C6-C8 hydrocarbon in a weight ratio of from 1:1 to 3:1.Type: GrantFiled: October 11, 2017Date of Patent: July 2, 2019Assignee: FAR EASTERN NEW CENTURY CORPORATIONInventors: Der-Ren Hwang, Cheng-Ting Wang, Hsiao-Chan Wang
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Patent number: 10336681Abstract: The patent discloses a process for the synthesis of dialkyl carbonates catalyzed by a catalyst composition AB oxides, wherein A and B are rare earth metals or A and B are combination of rare earth and transition metals with ratios ranging from 0.5:10 to 10:0.5.Type: GrantFiled: March 23, 2016Date of Patent: July 2, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Vivek Vinayak Ranade, Ashutosh Anant Kelkar, Vilas Hari Rane, Anil Kisan Kinage, Savita Kiran Shingote, Lalita Sanjib Roy
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Patent number: 10336682Abstract: A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.Type: GrantFiled: March 20, 2019Date of Patent: July 2, 2019Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Chengyuan Liang, Lei Tian, Yuzhi Liu, Xingke Ju, Nan Hui, Mi Wu, Juan Li, Han Li, Bin Tian, Qianqian Zhao, Gennian Mao, Nan Qin, Juan Xia, Zhenfeng Shi
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Patent number: 10336683Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.Type: GrantFiled: March 3, 2017Date of Patent: July 2, 2019Assignee: Genentech, Inc.Inventors: Stephan Bachmann, Serena Maria Fantasia, Michael Jansen, Stefan Koenig, Xin Linghu, Sebastian Rieth, Nathaniel L. Segraves, Andreas Zogg
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Patent number: 10336684Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.Type: GrantFiled: July 12, 2018Date of Patent: July 2, 2019Assignee: Bristol=Myers Squibb CompanyInventors: Peter T. W. Cheng, David S. Yoon
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Patent number: 10336685Abstract: The present invention relates to crystalline modification of (3,4-dichlorophenyl)propanamide (propanil), to a process for the preparation of the same, to pesticidal mixtures and compositions comprising the crystalline modification of 5 (3,4-di-chlorophenyl)propanamide and to a method of combating weeds using said mixtures and compositions.Type: GrantFiled: December 31, 2015Date of Patent: July 2, 2019Assignee: UPL LIMITEDInventors: Birja Shanker, Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff
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Patent number: 10336686Abstract: Provided is a fluorine atom-containing compound represented by formula (1) below (In the formula, Z represents a predetermined divalent group, each Ar independently represents a predetermined aromatic ring-containing group, and each ArF independently represents a predetermined fluorine atom-containing aryl group).Type: GrantFiled: January 11, 2017Date of Patent: July 2, 2019Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Taichi Nakazawa, Toshiyuki Endo
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Patent number: 10336687Abstract: The present invention relates to a selected amide of ?-hydroxybutyric acid, a process of manufacture and uses thereof. The invention also includes a pharmaceutical composition comprising an effective amount of the selected compound of the invention for use in preventing or treating drug addiction, especially alcohol misuse or dependency.Type: GrantFiled: August 3, 2016Date of Patent: July 2, 2019Assignee: LABORATORIO FARMACEUTICO C.T. S.R.L.Inventors: Roberto Cacciaglia, Antonella Loche
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Patent number: 10336688Abstract: The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.Type: GrantFiled: November 29, 2018Date of Patent: July 2, 2019Assignee: GLENMARK PHARMACEUTICALS S.A.Inventors: Sanjib Das, Laxmikant A. Gharat, Rajendra L. Harde, Dnyaneshwar E. Shelke, Shailesh R. Pardeshi, Abraham Thomas, Neelima Khairatkar-Joshi, Daisy M. Shah, Malini Bajpai
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Patent number: 10336689Abstract: A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.Type: GrantFiled: March 20, 2019Date of Patent: July 2, 2019Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Chengyuan Liang, Shunjun Ding, Nan Hui, Juan Li, Dezhu Zhang, Xiaolin Xie
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Patent number: 10336690Abstract: Methods for purifying an acetonitrile waste stream are provided. An exemplary method for purifying an acetonitrile waste stream includes generating an acetonitrile waste stream during oligonucleotide synthesis and fractionating the acetonitrile waste stream to produce a single overhead fraction. The method includes condensing the single overhead fraction to produce a condensed single overhead fraction and contacting the condensed single overhead fraction with an adsorbent material to produce an acetonitrile stream that comprises an amount of an impurity that is reduced relative to the acetonitrile waste stream.Type: GrantFiled: January 29, 2015Date of Patent: July 2, 2019Assignee: HONEYWELL INTERNATIONAL INC.Inventors: Gregory J. Gajda, Mark G. Riley, Venkatraman Mohan, Sandra M. Lorenz, Alan P. Cohen
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Patent number: 10336691Abstract: The present invention relates to compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: GrantFiled: June 1, 2016Date of Patent: July 2, 2019Assignee: Syngenta Participations AGInventors: Fides Benfatti, Andre Jeanguenat
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Patent number: 10336692Abstract: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3?-dithiodipropionic acid (DPDPA) and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.Type: GrantFiled: March 7, 2018Date of Patent: July 2, 2019Assignee: MAY-HWA ENTERPRISE CORPORATIONInventors: Hsien-Yeh Chen, Zhen-Yu Guan, Chih-Yu Wu
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Patent number: 10336693Abstract: An oseltamivir analog and nanoparticles having the analog bound thereto, of the present invention, strongly bind to oseltamivir-resistant influenza virus, and thus, the use of the same can allow detection of oseltamivir-resistant influenza viruses quickly and conveniently with the naked eye. Therefore, the present invention can be favorably utilized in promptly establishing a therapeutic schedule for a patient infected with influenza viruses.Type: GrantFiled: July 4, 2016Date of Patent: July 2, 2019Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Juyeon Jung, Eun Kyung Lim
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Patent number: 10336694Abstract: It is an object of the present invention to provide methods for producing vitamin D that gives improved yields and reduced side product contamination. In various aspects, these methods provide for production of vitamin-D2 using ergosterol as provitamin D2 or a dihydroxy derivative thereof as a starting material, or production of vitamin-D3 using 7-dehydrocholesterol as provitamin D3 or a dihydroxy derivative thereof as the starting material. The methods described herein comprise irradiating the starting material in a solution including an organic or inorganic base with light in the wavelength range 245-360 nanometers (nm) to obtain a product containing pre-vitamin-D2 or pre-vitamin-D3, and heating the product to convert the resulting pre-vitamin-D2 or pre-vitamin-D3 to vitamin D2 or vitamin D3. In various embodiments, these methods further comprise recovering vitamin D2 or vitamin D3 from this reaction as a purified product.Type: GrantFiled: December 18, 2015Date of Patent: July 2, 2019Assignee: NUCELIS LLCInventor: Laszlo Treiber
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Patent number: 10336695Abstract: The present invention provides a novel crystalline form I of hydrochloride, a crystalline form II of hydrochloride, a crystalline form of succinate, a crystalline form of tartrate, a crystalline form I of fumarate and a crystalline form II of fumarate of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine. The above-described novel crystalline forms have high solubility in water and excellent stability under moisture-proof conditions and high-humidity exposure conditions, and thus can be pharmaceutically used.Type: GrantFiled: March 17, 2017Date of Patent: July 2, 2019Assignee: Daewoong Pharmaceutical Co., Ltd.Inventors: Aeri Kim, Kwan Hyung Cho
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Patent number: 10336696Abstract: A photopolymerizable material contains, as a main polymerization component, a bicarbazole compound represented by structural formula (1). In structural formula (1), X1 and X2 are each independently a photopolymerizable functional group, a structural site having a photopolymerizable functional group, or a hydrogen atom, at least one of X1 and X2 is a photopolymerizable functional group or a structural site having a photopolymerizable functional group, R1 and R2 are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a bromine atom, or a chlorine atom, and at least one of R1 and R2 is a hydrogen atom.Type: GrantFiled: April 30, 2014Date of Patent: July 2, 2019Assignee: DIC CorporationInventors: Changjun Deng, Masanori Miyamoto, Nobuo Kobayashi, Xia Yang
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Patent number: 10336697Abstract: The present invention provides novel spiro[cyclobutane-1,3?-indolin]-2?-one derivatives of formula (I) in which Cy, R1, R2, R4, L, and m have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as bromodomain inhibitors in the treatment or prevention of diseases or disorders where bromodomain inhibition is desired.Type: GrantFiled: June 15, 2016Date of Patent: July 2, 2019Assignee: ORION CORPORATIONInventors: Ravi Kotrabasaiah Ujjinamatada, Susanta Samajdar, Chandrasekhar Abbineni, Subhendu Mukherjee, Tero Linnanen, Gerd Wohlfahrt
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Patent number: 10336698Abstract: A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.Type: GrantFiled: January 21, 2016Date of Patent: July 2, 2019Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Hermut Wehlan, Kai Rossen, Alexander Schaefer
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Patent number: 10336699Abstract: The present invention relates to a method for synthesizing N,N?-bis(2,2,6,6-tetramethyl-4-piperidyl)-1,3-benzenedicarboxamide as shown in the following formula (III), comprising the following steps that a compound of the following formula (I) and a compound of the following formula (II) react under stirring in an organic solvent in the presence of a solid supported catalyst, and after the completion of the reaction, a compound of the formula (III) is obtained by post-treatment, wherein R1 to R2 are each the same or different selected from C1-6 alkyl. The method can achieve good technical effects through the use of a unique catalyst and the compounding of the organic solvent, has the advantages of reduced pollution, good environment and significant improvement on yield compared with the prior art, can provide more inexpensive functional additives for the field of plastic processing, and has good industrial production prospects and application potential.Type: GrantFiled: October 8, 2017Date of Patent: July 2, 2019Assignee: SUNSHOW (YANTAI) SPECIALTY CHEMICAL COMPANY LIMITEDInventors: Xiuxiu Zhang, Xuqiao Gai
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Patent number: 10336700Abstract: Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease. For example, compounds of Formula I, compositions containing the compounds, and methods for using the compounds and compositions are provided herein: wherein X is absent, CH2, or C(O); R1 is H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino; R2 is H or C1-6 alkyl; R3 is H, C1-6 alkyl, —C(O)(C1-3 alkyl), or —C(O)O(C1-3 alkyl); R4 is C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups; and R5 is OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino.Type: GrantFiled: March 3, 2016Date of Patent: July 2, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Eugenia Trushina, Robert Greenhouse, Kevin Greenman, William Thomas
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Patent number: 10336701Abstract: The present invention is directed to pyridin-2-one derivatives, pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.Type: GrantFiled: August 9, 2018Date of Patent: July 2, 2019Assignee: Janssen Pharmaceutica NVInventors: Xuqing Zhang, Mark J. Macielag