Abstract: A fundus image capture system operates to determine if the system has captured an image that identifies the fundus, a region of interest in the image, or the current field of view. According to the determination, the system can guide the user to operate the system to capture a desired fundus image.

Abstract: A system includes a monitor configured to be coupled to multiple sensors over time to monitor one or more physiological characteristics of one or more patients. A first sensor of the multiple sensors includes a sensor memory, and the monitor is configured to transfer information to the first sensor for storage in the sensor memory of the first sensor. The information includes information related to one or more sensors of the multiple sensors that were coupled to the monitor prior to the first sensor.

Abstract: The subject matter disclosed herein provides methods for presenting glucose level data. Glucose data for a patient may be received. A current glucose level and a rate of change of the current glucose level may be determined based on the received glucose data. A first interface may be displayed on a screen of a device. The first interface may include a unitary icon. The unitary icon may display the current glucose level and a visualization of the rate of change. Related apparatus, systems, techniques, and articles are also described.

Abstract: A smart telehealth ECG recording system includes a wearable patch to be worn on a user's skin. The wearable patch includes a stretchable substrate, a pair of electrodes mounted in the stretchable substrate and configured to measurement a voltage signal across the user's skin to produce ECG data, a mechanical sensor configured to measure a pulse from the user's body to produce pulse data, an acceleration sensor configured to measure a movement of the user to produce movement data, an antenna over the stretchable substrate and in electric communications with the pair of electrodes, the mechanical sensor, and the acceleration sensor, wherein the antenna is configured to wirelessly transmit the ECG data, the pulse data, and the movement data associated with the user, and a circuit electrically connected with the pair of electrodes, the mechanical sensor, the acceleration sensor, and the antenna.

Abstract: Systems and methods for electronically monitoring chest sounds and/or sensing electrical cardiac signals such as ECG signals are provided. In one embodiment, a hybrid stethdiographer has a sensing assembly with a chestpiece and a user interface. Stethdiographer also includes a conduit, a power source compartment, a pair of binaurals and a corresponding pair of earpieces. The user interface includes a record button, a mode selector and a display screen. The chestpiece includes a diaphragm and a plurality of electrical cardiac sensors.

Abstract: Methods, systems, and devices for determining an adaptive health score are described. Methods may include receiving physiological information at a medical device and determining first and second patient health scores based in part on historical patient data and data associated with a larger population. The method may also include assigning complimentary first and second weighted values to the respective scores and, ultimately, determining an adaptive health score for the patient. In addition the method may update, or calculate a new adaptive health score, based on predetermined time intervals, or changes in the type or quantity of physiological data.

Abstract: For heart segmentation in magnetic resonance or other medical imaging, deep learning trains a neural network. The neural network, such as U-net, includes at least one long-short-term memory (LSTM), such as a convolutional LSTM. The LSTM incorporates the temporal characteristics with the spatial to improve accuracy of the segmentation by the machine-learnt network.

Abstract: An analyzer for diagnosing pulmonary and abdominals including, a pulsed force generator for outputting a mechanical disturbance to generate vibrations and reflected/return waves/vibrations in a patient's torso, and sensors for detecting the vibration/return wave signals. The apparatus compares the detected electrical signals with pre-stored reference wave profiles and based on the compared data generates an output signal indicative of a potential presence or absence of a pulmonary disease and/or condition.

Abstract: One aspect of the present disclosure relates to a handheld device that can be used to perform a screening or diagnostic test. The handheld device can include a disposable microsampler unit, an analysis unit, a controller unit, and an output unit. The disposable microsampler unit can collect 10 microliters or less of a sample. The analysis unit can include two electrodes that can apply alternating periods of coulometry and potentiometry to the sample to determine a total content of a target chemical in the sample. During the coulometry period, the two electrodes are a working electrode and a counter electrode, and during the potentiometry period the two electrodes are an indicator electrode and a reference electrode. The controller unit can control the sequence of coulometry and potentiometry. The output unit can display the total content of the target chemical in the sample.

Abstract: A device for cancer screening and triage using an optical coherence tomography (OCT) imaging system integrated with optical imaging probe is provided. Endoscopic OCT images are generated using the OCT system having a helical probe. The images are further analyzed to generate a depth resolved intensity OCT signal to classify the region of tissue into variable grades of dysplasia to guide the physician's biopsy or resection.

Abstract: Methods and apparatus are presented for confocal microscopy using dispersed structured illumination. In certain embodiments the apparatus also comprises an optical coherence tomography (OCT) system, and OCT images acquired from two or more regions of a sample are registered using a corresponding set of two or more larger area images acquired with the confocal microscopy system. In preferred embodiments the apparatus is suitable for analysing the retina of an eye. The confocal microscopy system can be operated in a purely intensity mode or in a coherent mode. In other embodiments a confocal microscopy system using dispersed structured illumination is utilised for surface metrology.

Abstract: A contactless system for assessing tissue viability and other hemodynamic parameters includes one or more light sources configured to emit lights at a predetermined wavelength sensitive to hemoglobin concentration associated with spontaneous hemodynamic oscillations at tissue in a predetermined area of a human subject. One or more polarizers are each coupled to one or more of the one or more light sources and are configured to polarize the light to a polarized state such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth and the polarized light is maintained in the polarized state at the predetermined depth. One or more detectors each including a detector polarizer coupled thereto are configured to discriminate the light maintained in the polarized state and at the predetermined depth and are configured to generate a plurality of frames of the tissue in the predetermined area at the predetermined depth.

Abstract: Devices, systems and methods useable for useable for monitoring a physiological variable in a target tissue or body fluid located within the thorax of a subject by optical spectroscopy.

Abstract: An intraoral scanning apparatus has a source of low coherence light. An interferometer directs the low coherence light to a reference path and a sample path and generates image data according to interference from combined light returned along the reference and sample paths. A fixture is optically coupled to the sample path and has a bite portion featured for clamping between the jaws of a patient, a track that defines a curved scan path for scanning, one or more scanners configured to direct the sample path light to and from the teeth, and an actuator and translation apparatus that urges the one or more scanners along the curved scan path. A control logic processor synchronizes light scanning and acquisition from the fixture. A display is in signal communication with the control logic processor for display of acquired scan data.

Abstract: An insert includes: a puncture needle main body which has an opening at a tip and is formed in a hollow shape and of which at least a tip portion is inserted into a subject; an optical fiber that is provided in a hollow portion of the puncture needle main body along a length direction of the puncture needle main body; and a photoacoustic wave generation unit that is provided at a light emission end of the optical fiber which is disposed on a tip side of the puncture needle main body, absorbs light emitted from the light emission end, and generates photoacoustic waves. A through-hole is formed in a wall portion forming the hollow portion and the photoacoustic wave generation unit is fixed to the through-hole.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for managing an esophagus of a subject during a medical procedure, such as cardiac tissue ablation or bronchial tissue ablation. Managing the esophagus may include displacing the esophagus, imaging the esophagus, and/or measuring temperature at one or more locations inside the esophagus. One example esophageal management system generally includes a tube configured for insertion through a mouth and into the esophagus of the subject. The tube generally includes a first port located at a proximal end of the tube and in fluid communication with a distal portion of the tube via a first path, a second port located at the proximal end of the tube, and a third port located between the proximal end of the tube and a distal end of the tube and in fluid communication with the second port via a second path.

Abstract: An electronic device includes a sensor, a memory, and a display, and a processor. The processor is configured to determine bio-information and blood pressure information of a user measured through the sensor, determine reliability of calibration of the blood pressure information, based on at least one of elapsed time of the calibration, the bio-information, and the blood pressure information, determine, based on the reliability of the calibration, whether an event associated with the calibration occurs, and display a user interface (UI) to request another calibration, through the display, when the event is determined to have occurred.

Abstract: A blood pressure measuring device, including a wristband, a control system, and a pressure sensing device, wherein the pressure sensing device is provided on the wristband; the control system is electrically coupled to the pressure sensing device; the pressure sensing device is configured to receive a pressure generated by skin surface and to generated an electrical signal; and the control system is configured to receive the electrical signal and to convert the electrical signal into a pulse wave, and to acquire a blood pressure value based on the pulse wave.

Abstract: A system for detecting blood pressure based on imaging photoplethysmography (iPPG) includes a first inward-facing head-mounted camera to capture images of a first region of interest located on the face below the eyes and above the lips (IMROI1) of a user, and a second inward-facing head-mounted camera to capture images of a second region of interest comprising a portion of a temple and/or forehead (IMROI2) of the user. The system further includes a computer to calculate a blood pressure value for the user based on first and second photoplethysmographic signals recognizable in IMROI1 and IMROI2.

Abstract: A sensor device includes a first light emitter that emits light with a wavelength from a first spectral range, a second light emitter that emits light with a wavelength from a second spectral range, a first light detector configured to detect light with a wavelength from the first spectral range, but not to respond to light with a wavelength from the second spectral range, and a second light detector configured to detect light with a wavelength from the first spectral range and light with a wavelength from the second spectral range, wherein a distance between the first light emitter and the first light detector is smaller than a distance between the second light emitter and the second light detector.

Abstract: Disclosed is a method for computerizing delineation and/or multi-label classification of an ECG signal, including: applying a neural network to the ECG, labelling the ECG, and optionally displaying the labels according to time with the ECG signal.

Abstract: A vital information measurement device and a vehicle seat which improves the durability of sheet-shaped sensors configured to detect vital information of a seated passenger can stably measure the heart rate of the seated passenger. A vehicle seat includes sheet-shaped sensors attached to a seat back, and can measure the heart rate of a seated passenger based on vital signals of the seated passenger detected by the sheet-shaped sensors. At each sheet-shaped sensor, a sensor overlap reduction section is provided to reduce partial overlapping of the sheet-shaped sensor when the seated passenger leans on the seat back. Specifically, each sheet-shaped sensor includes a first cutout extending toward the center of the sheet-shaped sensor at an outer peripheral portion of the sheet-shaped sensor, and a second cutout formed continuously from the first cutout and extending opposite to the center along the outer peripheral portion of the sheet-shaped sensor.

Abstract: In one embodiment, an ECG monitoring system includes two or more electrodes configured to record cardiac potentials from a patient, at least one processor, and a rapid acquisition module executable on the at least one processor to: determine that an impedance of each electrode is less than an impedance threshold; record initial ECG lead data based on the cardiac potentials; determine that a noise level in each ECG lead of the initial ECG data is less than a noise threshold; start a recording timer once the noise level is below the noise threshold; record an ECG dataset while the noise level is maintained below the noise threshold until the recording timer reaches a predetermined test duration; store the ECG dataset and provide a completion alert.

Abstract: According to one embodiment, an electrocardiographic (ECG) waveform timing detector includes an ECG waveform receiving circuit, a threshold value determining circuit, and a comparator. The threshold value determining circuit includes a heart rate calculating circuit, a threshold value setting circuit, and a comparing/determining circuit. The heart rate calculating circuit calculates the heart rate based on ECG waveform received by the ECG waveform receiving circuit. The threshold value setting circuit sets a threshold value. The comparing/determining circuit compares the heart rate with the number of R wave detection triggers detected using the threshold value to determine a threshold value for R wave detection trigger. The comparator compares the ECG waveform output from the ECG waveform receiving circuit with the threshold value for R wave detection trigger to output an R wave detection trigger.

Abstract: A method and system for determining a source of a cardiac rhythm disorder includes collecting cardiac signals at a plurality of locations during a cardiac arrhythmia and identifying activation times within the cardiac signals. After computing the time-dependent phase of each region of tissue, a level of phase synchrony is determined between each pair of locations to assign a synchronization number for each pair of locations. Using the synchronization number, a spatial synchrony map is generated to identify one or more asynchronous tissue regions surrounded by regions of synchrony in the patient's heart.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for determining a precise localization of an arrhythmia origin or exit site in a heart of a subject using internal electrocardiograph (ECG) signals sensed and stored by an implantable device implanted in the subject. One example method of analyzing an arrhythmia in a subject generally includes reading, from an implantable device implanted in the subject, a plurality of internal ECG signals sensed and stored by the implantable device while the subject was experiencing an arrhythmia event (e.g., at any time, including while the subject was ambulatory); performing an analysis of the read internal ECG signals; and determining a localization of the arrhythmia associated with the arrhythmia event, based on the analysis.

Abstract: An apparatus for measuring the fatigue of a user includes a first sensor configured to sense a factor causing the fatigue of a user; a second sensor configured to sense a brain wave signal of the user; and a processor configured to calculate a primary fatigue of the user based on the factor sensed by the first sensor, to calculate a secondary fatigue of the user based on the brain wave signal sensed by the second sensor, and to measure the fatigue of the user by using the primary fatigue and the secondary fatigue.

Abstract: An augmented reality system and methods for improving augmented reality are presented herein. Such systems are configured to monitor the brain state of an individual and configured to create a feedback loop whereby the brain state of the individual modulates parameters of the augmented reality system, thereby changing the augmented reality presented to the individual and tailoring the augmented reality presented to the individual in real time to suit the particular needs of the individual at any particular moment in time. Also presented herein are methods designed to monitor the brain state of an individual and create a feedback loop whereby the brain state of the individual modulates parameters of the augmented reality system, thereby changing the augmented reality presented to the individual and tailoring the augmented reality presented to the individual in real time to suit the particular needs of the individual at any particular moment in time.

Abstract: The present invention is related to a wearable physiological activity sensor, sensing device and sensing system, which employs at least an ear-worn structure to install physiological sensing element(s), thereby acquiring physiological signals from the head and/or the ear(s) of a user. The sensor, sensing device and sensing system also can be used to perform procedure(s) capable of influencing the user's physiological state in accordance with the physiological signals.

Abstract: Methods and apparatus for mitigating neuromuscular signal artifacts are described. The method comprises detecting in real-time, by at least one computer processor, one or more artifacts in a plurality of neuromuscular signals recorded by a plurality of neuromuscular sensors, determining, based at least in part, on the detected one or more artifacts, a plurality of derived neuromuscular signals to mitigate the one or more artifacts, and providing, as input to one or more trained statistical models, the plurality of derived neuromuscular signals.

Abstract: Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

Abstract: A medical image diagnostic apparatus has an imaging unit that images volume data of a region-of-interest of an object, an extracting unit that extracts a characteristic point from the volume data; and, a generating unit that generates an observation sectional image from tile volume data using the characteristic point and correlation parameters.

Abstract: This disclosure relates to wireless electronics designed for use within the oral cavity to measure biological or chemical variables, including pH or analyte concentrations, and transmit the measurements. More particularly, the disclosure relates to a wearable intraoral sensor comprising sensing electronics arranged within a flexible circuit mounted onto a molar band, a wireless transmission unit coupled to the sensing electronics and configured to wirelessly transmit electrical data signals to a receiver outside of the oral cavity, and a power source operably coupled to the sensing electronics and wireless transmission unit. The wearable intraoral sensor can be installed around a tooth and continually measure and wirelessly transmit measurement data for extended periods of time without user action.

Abstract: The present invention provides a system and method for multi-phase flow decomposition using electrical capacitance imaging techniques. The present invention provides a system and method to obtain permittivity distributions at a plurality of frequency markers using volume tomography image reconstruction to determine volume fraction of each phase and to produce images of the volume fraction for each phase.

Abstract: A system includes an electrical interface and a processor. The electrical interface is configured for communicating with a probe inserted into a heart of a patient. The processor is configured to receive, via the electrical interface, (i) a first indication of an electrical impedance measured by the probe at a given location on an inner surface of the heart, and (ii) a second indication of a quality of mechanical contact between the probe and the inner surface of the heart during measurement of the electrical impedance. The processor is further configured, based on the first and second indications, to classify tissue at the given location as scar tissue.

Abstract: Systems and methods for performing, assessing, and adjusting neuromodulation therapy are disclosed herein. One method for assessing the likely efficacy of neuromodulation therapy includes positioning a neuromodulation catheter at a target site within a renal blood vessel of a human patient and obtaining a measurement related to a diameter of the renal blood vessel via the neuromodulation catheter. The method can further include determining a diameter of the renal blood vessel at or near the target site based on the measurement. In some embodiments, (i) one or more parameters of neuromodulation energy to be delivered to the renal blood vessel can be adjusted based on the determined diameter and/or (ii) the neuromodulation catheter may be repositioned within the renal blood vessel.

Abstract: A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.

Abstract: A position sensor used in medical devices for use with medical positioning systems. The position sensor includes a core (80) having a body and one or more projections (841,842) extending from the body, wherein the core comprises a high-permeability material. The position sensor further includes a coil (74) surrounding the body, wherein the coil is configured to generate a voltage when subject to a magnetic field. The one or more projections extending from the body of the core are configured to concentrate the magnetic field into the coil and increase the voltage. Thus, various core designs are described which have projections which may increase the electrical and/or mechanical integrity of the position sensor and/or which may also induce magnetic flux flow within the position sensor thereby increasing the signals generated by the position sensor.

Abstract: A medical device-placing system is disclosed including, in some embodiments, a medical-device tip-location sensor (“TLS”) configured for placement on a chest of a patient, an ultrasound probe, a console, and an alternative-reality headset. The ultrasound probe is configured to emit ultrasound signals into the patient and receive echoed ultrasound signals from the patient. The console is configured to transform the echoed ultrasound signals to produce ultrasound-image segments corresponding to anatomical structures of the patient, as well as transform TLS signals from the TLS into location information for a medical device within the patient. The alternative-reality headset includes a display screen through which a wearer of the alternative-reality headset can see the patient. The display screen is configured to display over the patient a virtual medical per the location information for the medical device within objects of virtual anatomy corresponding to the ultrasound-image segments.

Abstract: A composite planarity member for a medical device that can comprise a planarity member and a tracking sensor coupled to the planarity member. A catheter that can comprise a tip electrode, a catheter body comprising a lumen, the catheter coupled to the tip electrode, and a composite planarity member comprising a planarity member and a flat coil coupled to the planarity member, wherein the composite planarity member is disposed within the lumen of the catheter body.

Abstract: A medical puncture device system includes a puncture device, a sensor, and an indicator system. The puncture device is configured to create a puncture through patient tissue and into an internal patient cavity to enable a medical tool to be inserted through the puncture into the cavity. The sensor is configured to generate a signal indicative of motion of the puncture device through the tissue into the cavity. The indicator system is operable by a controller to produce human-perceptible feedback in response to the signal generated by the sensor.

Abstract: A registration method whereby a sensor-based approach is used to establish initial registration and whereby upon the commencement of navigating an endoscope, image-based registration methods are used in order to more accurately maintain the registration between the endoscope location and previously-acquired images. A six-degree-of-freedom location sensor is placed on the probe in order to reduce the number of previously-acquired images that must be compared to a real-time image obtained from the endoscope.

Abstract: A method and apparatus for non-invasive assessment of lung inhomogeneity by accurate high temporal resolution measurement of respiratory gas flows at the mouth during steady state breathing and inert gas wash-in or wash-out and using these measurements to fit a mathematical model of the inhomogeneous lung. The model of the lung is based on modelling the lung as plural alveolar compartments each having an identical volume at functional residual capacity, but varying in its fractional share of total lung compliance, total pulmonary vascular conductance and total anatomical deadspace. A bivariate log-normal distribution of the lung compliance and pulmonary vascular conductance is used, together with a normal distribution of deadspace fraction.

Abstract: A strain sensor unit and a skin sensor module comprising the same are provided. The strain sensor unit according to an embodiment of the present disclosure includes a substrate having a through-hole, and including a first electrode and a second electrode formed at one side and the other side of the through-hole on one surface of the substrate, a piezoelectric device drawn from the first electrode and extending inward the through-hole, and a piezoresistor drawn from the second electrode and extending inward the through-hole, wherein the piezoresistor overlaps with a whole or part of the piezoelectric device.

Abstract: The present invention is a system and method for identifying certain physical properties of human feet. The system uses electronic and optical elements to perform before and after pronation test and before and after arch tests (meaning before and after use of an orthotic), and develop a 360 degree, three-dimensional view of the foot. It includes an insertable shoe-simulator used to assist in providing before- and after analysis of pronation.

Abstract: Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four calculations. The present system can automatically sense train of four response of a patient and reduce the likelihood of false train of four indications.

Abstract: This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

Abstract: This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

Abstract: An injector for cm 11transcutaneously introducing a sensor into a patient, including a cannula, a sensor arranged in the cannula, a base element, a sliding element arranged displaceably on the base element in an injection direction, for transcutaneously introducing the cannula having the sensor into the patient in an injection operation. The cannula has a slot in a longitudinal direction of the cannula. The injector has a holding element arranged displaceably on the base element that, in an ejection operation, prevents the sensor from being pulled out as the cannula is withdrawn, by engaging in a distal end region of the sensor through the slot into the cannula. The holding element and/or base element have at least one fixing arrangement to automatically lock the holding element on the base element when the cannula is introduced transcutaneously into the patient. A method for transcutaneously introducing a sensor into a patient is also provided.

Abstract: An injector for transcutaneously introducing a sensor into a patient, including a cannula, a base element, a sliding element arranged displaceably on the base element, for transcutaneously introducing the cannula into the patient in an injection direction, and including an ejection element for automatically pulling the cannula out of the patient counter to the injection direction by the ejection element in an ejection operation. The injector has a locking element for the ejection element such that, in a delivery state, the ejection element is lockable in an energy-charged state, and the sliding element and the locking element are configured to interact indirectly or directly in order, in an injection state, when the cannula is introduced transcutaneously into the patient, to release the locking of the ejection element in order automatically to start the ejection operation.