Abstract: A drainage bag is provided for a thermal control unit adapted to deliver temperature-controlled liquid to a patient in order to control the patient's temperature. The drainage bag is used to hold and transport the liquid when the liquid inside the thermal control unit is changed. The drainage bag includes a bottom layer, a top layer sealed thereto, and a float secured to the top layer that is positioned adjacent an opening in the top layer. As the liquid from the thermal control unit drains into the opening in the top layer, the liquid lifts the float and the float lifts the top layer of the bag. The bag thereby expands its volume to accommodate the liquid from the thermal control unit. The bag may further be designed to be carried without sealing the opening and without spilling the liquid. A method for using the bag is also disclosed.

Abstract: Embodiments of negative pressure wound therapy systems and methods are disclosed. In one embodiment, an apparatus includes a housing, negative pressure source, circuit board, and one or more controllers. The circuit board can be supported by the housing and include a conductive pathway extending around at least part of a perimeter of a first side of the circuit board. The conductive pathway can be electrically coupled to an electrical ground for the circuit board. The one or more controllers can be mounted on the circuit board and activate and deactivate the negative pressure source.

Abstract: A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.

Abstract: An apparatus is disclosed for collecting fluid during a medical or a surgical operation. The apparatus can include positions for collection containers, a pressure sensor and a manifold having a housing, at least one port for connecting to a patient, more than one port for collection container tubes extending from the manifold to a collection container and a by-pass channel for connecting to the pressure sensor.

Abstract: A device for removing fat from a body can include a pair of nested hollow members that each has at least one opening and an adjustment means for adjusting the orientation of the nested hollow members from a first configuration to a second configuration to change an amount of overlap between openings in the nested hollow members. The nested members can be deformable to change the shape of the openings.

Abstract: A multi-layer dressing for treating tissue with negative pressure, instillation, or both. In some embodiments a first layer may be formed from reticulated foam having a series of holes. A second layer disposed adjacent to the first layer may be formed from a perforated polymer. The dressing may optionally include a third layer formed from a soft polymer, such as a silicone gel. The third layer may also have perforations or apertures. The third layer is generally oriented to face a tissue site, and may be disposed adjacent to the first layer so that the first layer is disposed between the third layer and the first layer. The perforations or apertures in the third layer may be registered with one or more perforations in the first layer.

Abstract: Certain embodiments described herein are directed to an elongated layer of material and a lip to be placed in contact with a wound and the elongated layer of material to be wrapped around a wound filler, their methods of use and systems incorporating the same, wherein the wound filler lip is configured to be positioned beneath the fascia. Additionally, some embodiments described herein are directed to the closure of the wound and the use of attachment mechanisms on the elongate layer and lip to attach to the wound surface.

Abstract: Apparatuses and methods disclosed herein relate to various embodiments of wound fillers that, in some cases, preferentially collapse in one direction as compared to another direction. Such apparatuses and methods may aid in the closure of wounds and may further be used in combination with pressure sensors and controllers to provide for controlled collapse of the wound fillers.

Abstract: Embodiments of negative pressure wound therapy systems and methods are disclosed. In one embodiment, an apparatus includes a housing, a negative pressure source, a canister, an antenna, and one or more controllers. The negative pressure source can provide negative pressure via a fluid flow path to a wound dressing. The canister can be positioned in the fluid flow path and collect fluid removed from the wound dressing. The antenna can be supported by the housing and wirelessly communicate with an electronic device. The antenna can be oriented in the housing to face downward toward the ground when the negative pressure source is providing negative pressure. The one or more controllers can activate and deactivate the negative pressure source and transmit first data to the electronic device using the antenna or receive second data from the electronic device using the antenna.

Abstract: The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue.

Abstract: Provided are a blood bag system and a blood treatment method capable of securely and efficiently obtaining a medium specific gravity blood component having a sufficiently low content rate of a light specific gravity blood component. In a blood bag system (10) used for a blood treatment method, in a transfer completed state in which whole blood in a first bag (12) is centrifuged to transfer blood plasma to a second bag (14) through a first transfer tube (24) and transfer red cell concentrates to a third bag (16) through a second transfer tube (26), a buffy coat is left in the first bag (12). In the transfer completed state, when a platelet added solution is transferred from a fourth bag (18) to the first bag (12) on which a centrifugal force acts through a third transfer tube (28), blood plasma in the buffy coat is discharged from the first bag (12).

Abstract: A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

Abstract: Apparatus and methods are described, including apparatus (20) for implanting in a heart of a human subject. The apparatus includes an interatrial anchor (22) shaped to define an opening (26) having a diameter of 4-8 mm, and a bag (24) in fluid communication with the opening of the anchor. The apparatus is shaped to fit within a right atrium of the heart of the subject, and has a capacity of between 4 and 20 cm3. Other applications are also described.

Abstract: The present technology provides a blood pump device and associated systems and methods of use thereof to assist blood circulation in a patient. The blood pump device includes a flexible member disposed within a housing. Movement of the flexible member in the housing varies the volume of chambers within the housing and effectuates pumping of blood to and from a vessel in fluid connection with a chamber of the blood pump device.

Abstract: A method of controlling a blood pump including executing a control command to temporarily displace an impeller of the blood pump within a pump housing from a first axial position relative to the pump housing to a second axial position a distance away from the first axial position using a vector control method, and causing the impeller to move from the second axial position to a third axial position, the third axial position including a positive and a negative displacement of the impeller relative to the first axial position.

Abstract: A method of determining an adverse event within a patient having an implantable blood pump including calculating a plurality of power consumption trends of the blood pump during a plurality of time periods using a low-pass filter, determining a plurality of power trend differences between the plurality of power consumption trends, calculating a total amount of the plurality of power trend differences during a time interval, and generating an alarm when the total amount of the plurality of power trend differences exceeds a pre-determined threshold.

Abstract: Methods and apparatus for estimating flow rate in a blood circulation assist system employing impeller eccentricity. A method includes magnetically rotating an impeller within a blood flow channel of a blood pump. The impeller is levitated within the blood flow channel transverse to the impeller axis of rotation. A rotational speed for the impeller is determined. At least one impeller transverse position parameter is determined. The at least one impeller transverse position parameter is based on at least one of (1) an amount of a bearing current that is used to levitate the impeller transverse to the impeller axis of rotation, and (2) a position of the impeller within the blood flow channel transverse to the impeller axis of rotation. A flow rate of blood pumped by the blood pump is estimated based on the impeller rotational speed and the at least one impeller transverse position parameter.

Abstract: A system for omni-orientational wireless energy transfer is described. A transmitter unit has a transmitter resonator with a coil that is configured to be coupled to a power supply to wirelessly transmit power to a receiver unit. A receiver unit has a receiver resonator with a coil coupled to a device load. At least one of the resonators is a non-planar resonator that spans a non-degenerate two-dimensional surface having at least one concave portion.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: This dialysis device is configured so that residual liquid in a powder container 42 and a bypass path 51 can be drained. Accordingly, the dialysis device is provided with: a first liquid draining path 71 connecting a clean water supply path 31 to a stock solution supply path 44 on the upstream side of a liquid feed pump 33; a second liquid draining path 72 connecting the clean water supply path to a dialysate discharge path 32 on the downstream side of the liquid feed pump; and an opening path 77 allowing a branch path 43 to communicate with the outer space by opening an on-off valve 78. By opening the on-off valve of the opening path and actuating the liquid feed pump, a liquid in the powder container 42 and a liquid in the bypass path 51 can be discharged through the first liquid draining path and the second liquid draining path.

Abstract: A dialysis system comprising a sorbent cartridge for fluidly communicating with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication with the sorbent cartridge and the storage container; and a control unit in operable communication with the pump to cause the pump to (i) recirculate a dialysis fluid through the sorbent cartridge for at least two recirculation cycles such that the dialysis fluid in each cycle contacts the zirconium phosphate layer first before contacting the at least one of the urease layer, zirconium oxide layer or carbon layer, and (ii) store the dialysis fluid in the storage container after the at least two recirculation cycles.

Abstract: Methods and design for a Slotted T-shaped PD Catheter are disclosed. The present invention includes a unique port design for peritoneal dialysis catheters that allows high outflow and inflow rates, with a minimum fluid velocity through the fluid entry ports. Features of this device include T-shaped catheter with subcutaneous tubing joining to an intraperitoneal portion that is essentially at right angles to the intraperitoneal tubing and slit shaped flow ports as opposed to round shaped flow ports.

Abstract: Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. The flow control assembly includes one or more components that interact with the blood flow through the shunt.

Abstract: A device and method are used for monitoring an extracorporeal blood treatment device, such as a dialysis machine, which includes an extracorporeal blood circuit having an arterial blood line with an arterial patient port and/or at least one venous blood line with a venous patient port, and a dialysis fluid system which has a dialysis fluid supply line and a dialysis fluid drain line. The monitoring device selects and senses a measured value during operation of the extracorporeal blood treatment device which is suitable for monitoring the blood treatment device to compare a time-related actual course of the measured value with a target course of the measured value stored in a memory, and to determine that there is a defect if, at least in sections, the actual course of the measured value deviates from the target course by more than a defined tolerance.

Abstract: A method for continuously washing packed red blood cells includes (1) transferring, at a first flow rate, packed red blood cells from a container to a separation device and (2) transferring, at the same time as the packed red blood cells, wash solution from a container to the separation device. The wash solution may be transferred at a second flow rate that is greater than the first flow rate. The wash solution mixes with the packed red blood cells within the inlet line of the separation device and dilutes/washes the packed red blood cells. The separation device separates the red blood cells from the wash solution and a supernatant. The method may then monitor the volume of washed red blood cells within the separation device and begin to extract the washed red blood cells into a red blood cell product container when a target volume is collected within the separation device.

Abstract: A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core.

Abstract: The present invention relates to an apparatus for flow tempering medical irrigation fluids and to a method carried out with the aid of this apparatus.

Abstract: A pump with a controller for adjusting head pressure using a pressure boost is provided. The pressure boost may be dynamically adjusted during a surgical procedure based on the device being used and inflow and/or outflow settings.

Abstract: A pressure regulation system for discharging a liquid having a predetermined liquid pressure from a liquid opening, including an elastic bag having a liquid phase and a gas phase, where the liquid opening in an operational position of the elastic bag is formed in the lower area of the elastic bag, at least two push elements, at least one drive unit and a control unit. The elastic bag has a gas opening, which extends into the gas phase. The pressure regulation system has a ventilation unit, which is connected to the control unit for communication and which connects to the gas opening of the elastic bag. The ventilation unit regulates the liquid pressure of the liquid discharged through the liquid opening by means of a gas supply into the elastic bag and/or a gas discharge from the elastic bag.

Abstract: A catheter for use with an injection apparatus, preferably for rectal irrigation. The catheter has a main body with a funnel-shaped part delimited by an annular funnel wall which tapers into an elongate tubular catheter part delimited by an annular catheter wall. The main body accommodates at least a liquid flow channel and a fluid flow channel and the liquid flow channel is adapted to expel a liquid via at least one injection opening in a free end of the elongate tubular catheter part opposite the funnel-shaped part. An expandable balloon surrounds an elongate fixation section of the elongate tubular catheter part a distance from its free end, and the fluid flow channel is adapted to, via at least one delivery opening provided in the annular catheter wall of the elongate fixation section of the elongate tubular catheter part, deliver a fluid to the expandable balloon.

Abstract: An example system for administrating a liquid medication includes a syringe assembly including a barrel portion containing liquid medication, a plunger portion sealingly engaged with the barrel portion to form a chamber for expelling the liquid medication from the barrel portion, and a needle. A ring is positioned about the plunger portion of the syringe assembly, wherein the ring limits movement of the plunger portion in an axial direction as the plunger portion is moved in the axial direction to administer a first dose of the liquid medication. The ring is configured to be modified to allow the plunger to move further in the axial direction to administer a second dose of the liquid medication.

Abstract: A medical device packaging comprises a container having an opening. A medical device is disposed within the container. The medical device includes an adhesive contact face facing the opening. A first cover is disposed over the opening in the container to close the container. A second cover is disposed over the adhesive contact face of the medical device. The first and second covers are connected such that removal of the first cover from the container causes detachment of the second cover from the medical device.

Abstract: A retaining device for use with various medical equipment attached to the body such as PODs, CGMs (Continuous Glucose Monitors) or other equipment is connected to the body assists in protecting the medical equipment, and hopefully prevents the medical equipment from being dislodged, or even lost during strenuous activity.

Abstract: A needle insertion and retraction mechanism for a drug delivery device, comprises a motion source, a user-operated control for the motion source, an interrupter for stopping motion of the motion source at a predetermined location and thereby dividing the motion into two parts which are continuous relative to each other. A motion translation mechanism connects the source of continuous motion to a needle, to extend the needle during the first motion part and to retract the needle during the second motion part. The needle is thus extended and retracted by continued operation of a single tension source rather than two tension sources operating in opposition to each other. The motion source may be a spring, and a winding mechanism may be provided to wind the spring. The second motion part may be initiated by pulling the adhered delivery device from the skin.

Abstract: Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.

Abstract: A fluid injector including an injector housing with at least one syringe port for receiving a syringe, and a locking mechanism associated with the at least one syringe port for securing the syringe within the at least one syringe port. The locking mechanism is configured for engaging at least one syringe retaining member of the syringe to releasably lock the syringe within the at least one syringe port. The at least one syringe retaining member rotationally guides the syringe into self-orienting alignment with the locking mechanism and is rotated by the locking mechanism into fully locked position after axial installation of the syringe into the at least one syringe port. The locking mechanism also axially ejects the syringe from the locking mechanism upon rotation of the syringe during removal.

Abstract: An intravenous tubing set is provided having a coupling component for accessing a source of flush solution; a flush chamber; a first IV tubing for delivering saline solution from the source of flush solution to the flush chamber; a first flow control device disposed in the tubing between the source of flush solution and the flush chamber to control the flow of flush solution into the flush chamber; a second IV tubing for delivering flush solution to a patient catheter; and a second flow control device disposed in the second tubing between the flush chamber and the patient catheter.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.

Abstract: A wearable automatic injection device is provided for administering a final medicament to a patient. The wearable automatic injection device comprises a housing, an injection assembly for injecting the patient with the final medicament, a container holding a bulk intermediate medicament and a diluent to be mixed to form the medicament, and a mixing mechanism for mixing the bulk intermediate medicament and the diluent in the container to form the final medicament prior. A system for administering a final medicament to a patient is also provided. The system comprises a container, a mixing mechanism for mixing a bulk intermediate medicament and a diluent in the container to form the final medicament, and a wearable automatic injection device configured to receive the container.

Abstract: A drug delivery device comprising a housing body; a piston rod configured to rotate in a first direction during dose dispensing under a driving force; and a threaded insert, wherein the piston rod is in threaded engagement with the threaded insert such that during dose dispensing, the piston rod displaces axially in a distal direction relative to the threaded insert for displacement of a cartridge bung. The threaded insert is movable relative to a stop provided in the housing body and a resilient means is provided to bias the threaded insert against the stop so that rotation of the piston rod causes the threaded insert to move away from the stop in response to reaction forces acting on the piston rod (in a proximal direction when the reaction forces exceed the biasing force of the resilient means.

Abstract: A cartridge retainer comprises a sleeve having a distal end a proximal end and a longitudinal axis extending between the distal end and the proximal end. One or more tabs extend radially from the sleeve toward the longitudinal axis and are configured to radially deflect away from the longitudinal axis. One or more deformable members extend axially from the distal end of the sleeve toward the one or more tabs and are configured to deform in a longitudinal direction toward the distal end.

Abstract: An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).

Abstract: A living cell transplanting device has a flexible tube capable of accommodating living cells and a cell pushing shaft inserted into the tube. The tube has a lumen penetrating therethrough and a reduced diameter front end open portion. The shaft has a small diameter end portion having a diameter smaller than that of the reduced diameter front end open portion and an enlarged diameter portion having an outer diameter larger than an inner diameter of reduced diameter front end open portion. Owing to contact between the enlarged diameter portion of the shaft and the reduced diameter front end open portion of the tube, a progress of the shaft is regulated.

Abstract: A colored seal system, method, and apparatus. The colored seal system includes a barrel having a delivery end and an open end. The barrel includes multiple markings. The barrel markings include at least measurements and multiple fill indicators. The colored seal system includes a colored seal slidably positioned within the barrel for moving a delivery agent. The colored seal is visible within at least one of the fill indicators.

Abstract: Flush syringe assemblies are described herein. Such flush syringe assembly may include a barrel including a side wall defining a chamber, a collar mounted on a distal wall of the barrel and surrounding an elongate tip. A cap may be attached to the collar via a hinge. The flush syringe assembly may also include a cap attached to the collar via a hinge. A ring may be disposed around the collar with a locking element that engages with a corresponding mating locking projection on the cap. The cap may include a slanted surface. The slanted surface of the cap may include one or more ribs made of an elastomeric material.

Abstract: Flush syringe assemblies are described herein. Such flush syringe assembly may include a barrel including a side wall defining a chamber, an open proximal end, a distal end having a distal wall with an elongate tip extending distally therefrom having a passageway therethrough in fluid communication with said chamber. A collar may be mounted on the distal wall of the barrel and surrounding the elongate tip. The flush syringe assembly may also include a removable cap.

Abstract: The present invention relates to incorporation of in-line filter into the drug administration device to minimize the entry of particulates into the human body during injection of therapeutic proteins/peptides. Particulate matter can be of non-proteinaceous and/or proteinaceous and/or mixture thereof. Particles such as undissolved or precipitated solids, fibers, glass flakes, rubber fragments, silicone oil etc. represent non proteinaceous particles while protein aggregates (amorphous and fibrils) represent proteinaceous particles. Although particulate matter in injectable formulation require to be controlled within various regulatory and compendial limits, methods to minimize particulate matter further are beneficial as proteinaceous particulates poses the risk of immunogenicity.

Abstract: The invention relates to an injection unit, preferably a pen-shaped injection unit, for administering or delivering a fluid product. The injection unit comprises a housing, an axially movable piston rod mounted in the housing in a non-rotatable manner, a delivery apparatus having a threaded nut that is able to move the piston rod in order to deliver product, a dosing device having a dosing sleeve, a rotary knob, a discharge button arranged coaxially on the dosing sleeve, and a receptacle for the product. The dosing device is connected to the delivery apparatus via a coupling mechanism, wherein the coupling mechanism includes of at least two coupling surfaces that each carry a toothing comprising teeth, wherein the coupling surfaces are used to generate an acoustic and/or tactile signal corresponding to the set or corrected dose of the product to be administered during the dosing operation or during correction of the dose.