Abstract: The invention relates to an artificial bacteriophage for supplying medicaments, nutrients, proteins, DNA/RNA or other type of molecules to bacteria and/or diseased cells, directly to the cytoplasm, passing through the cell membrane thereof, through a pore of said membrane. The artificial bacteriophage is based on carbon nanostructures and comprises a nanocontainer for medicaments, a channel for transporting medicaments and a tip together with an array of linker proteins and protein receptors.

Abstract: The invention relates to a liquid formulation comprising propylene glycol and an effective amount of an inodilator, an angiotensin converting enzyme inhibitor, or a combination of an inodilator and an angiotensin converting enzyme inhibitor and to use of the formulation for treating cardiac disease and/or hypertension.

Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.

Abstract: Provided are drug delivery compositions and devices useful for the treatment and/or prevention of cancer and metastatic tumors. For example, a drug delivery device is provided that comprises a biodegradable scaffold carrying one or more anti-cancer therapeutic agents that activate the innate immune system (e.g., STING agonists) and/or the adaptive immune system (e.g., anti-PD-1 antibodies). The compositions and devices may include a cytokine (e.g., IL-15 superagonist). The drug delivery device can be implanted in the void volume of a resected tumor to prevent tumor regrowth and tumor metastasis. Also provided are methods of making the drug delivery compositions and devices as well as kits containing materials to provide the compositions and devices.

Abstract: The invention relates to a method for producing a mixture containing a hydrated egg product and a substance of interest, wherein the mixing is carried out by means of ultrasonic nebulization. The method comprises: beating at least one egg product until it is in a foam state; adding at least one substance of interest, in the form of a pressurized mist, to the foamy egg product; mixing until an emulsified mixture in a foam state is obtained; suctioning the emulsified mixture in order to transfer same to a dehydrator; dehydrating the emulsified mixture until a moisture level no greater than 5% is obtained; grinding the emulsified mixture to the desired grain size distribution; and sterilizing the ground mixture. The invention also relates to the mixtures produced using said method, and to the products containing said mixture.

Abstract: The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds, to a process for the preparation of the conjugate, to the use thereof for the protection of the kidney against nephrotoxic active compounds, and to a medicament comprising the conjugate.

Abstract: The present invention provides a novel process for preparing a cell-binding agent cytotoxic agent conjugate. The process comprises the steps of: (a) reacting a cytotoxic agent with a bifunctional crosslinking reagent represented by the structural formula (I) or a salt thereof, in a buffer solution comprising a buffering agent to provide a first mixture comprising a cytotoxic agent-linker compound, wherein the buffer solution has high buffer capacity; and (b) reacting the first mixture comprising the cytotoxic agent-linker compound from step (a) with a cell-binding agent in a solution having a pH of 4 to 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate. The cell-binding agent cytotoxic agent conjugates prepared according to the processes described herein are also included in the present invention.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug deliver}?. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

Abstract: Methods and products for altering or promoting the development of heart tissue are disclosed. The methods include the use of nucleic acids of cardiogenic inducing factor for treating a subject having heart disease.

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

Abstract: A first light source emits near-infrared radiation with a wavelength near 810 nm, which is excitation radiation for exciting indocyanine green, a second light source emits a violet light with a wavelength of 410 nm that is excitation radiation for exciting PpIX, and a third light source emits white light. An imaging portion comprises a first imaging element able to capture visible light, a second imaging element able to capture red light that is emitted by the PpIX, and a third imaging element able to capture near-infrared light emitted by the indocyanine green.

Abstract: The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to C3d (mAB 3d29) for imaging and methods of use thereof for detecting infectious and inflammatory cells in vivo. The presently disclosed subject matter also provides methods for detecting and/or monitoring a Mycobacterium tuberculosis (M. tuberculosis) infection in a subject, as well as methods of treating a M. tuberculosis infection in a subject.

Abstract: A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.

Abstract: A system for sanitizing a tray table may include a sanitation assembly operatively coupled to the tray table. The sanitation assembly includes an ultraviolet (UV) light source configured to emit UV light, and a sanitation control unit operatively coupled to the UV light source. The sanitation control unit operates the UV light source to emit the UV light onto the tray table when the tray table is secured in an upright position, and prevents the UV light source from emitting the UV light when the tray table is not secured in the upright position.

Abstract: A germicidal device is disclosed. The germicidal device may include a flexible panel that can be rolled up and/or folded. A plurality of LEDs embedded in the panel and a plurality of lenses are embedded in the panel. The panel includes an input connector coupled to the panel that receives input at a first voltage from a power source. The LEDs are coupled to the input connector and provided a second voltage that is suitable for operating the LEDs. The panel also includes one or more output connectors on the panel. The output connectors provide the first voltage as an output voltage from the panel. The panel may be coupled to additional panels with the additional panels receiving the first (output) voltage from the first panel as input voltage to the additional panels.

Abstract: A portable light fastening assembly for use with the human interface of an electronic device includes a lamp housing and an adjustable attachment device extending from the lamp housing. An ultra-violet (UV) light source is at least partially enclosed in the lamp housing such that the adjustable attachment device includes an engagement member and a receptacle housing such that the engagement member can be removably fastened within the receptacle housing for holding the lamp housing in a fixed position.

Abstract: A modular light assembly for an ultraviolet (UV) treatment device includes a UV light reflective surface. First and second sidewalls are coupled to respective sides of the reflective surface. Electrical input contacts are formed on each of the first and second sidewalls for receiving electrical power, and electrical output contacts are formed on each of the first and second sidewalls for delivering electrical power. A plurality of UV lamps are included, each of which have a first end and a second end. The first end of each of the UV lamps is coupled to a respective one of the electrical output contacts on the first sidewall, and the second end is coupled to a respective one of the electrical output contacts on the second sidewall.

Abstract: Disclosed herein is a multiple light emitter device which inactivates microorganisms. The device includes at least two light emitters and at least one light-converting material arranged to convert at least a portion of light from the light emitters. Any unconverted light emitted from the light emitters and converted light emitted from the at least one light-converting material mixes to form a combined light, the combined light being white. In one aspect, the light emitters include at least one blue light emitter and at least one violet light emitter. In another aspect, the light emitters include one blue light emitter and one emitter within the range of approximately yellow to infra-red light.

Abstract: A communicating sterile scale is described suitable for automated use in animal cages. An upper module provides a weighing platform, electronics, upward facing wireless communication elements, a protecting skirt, and interface to a combined weight-bearing and electrical penetration element. A lower module provides a case, internal electronics, load cell, power source, sterile-sealed flexible complaint membrane and a combined weight bearing and electrical penetration element through the membrane. The upper and lower modules are easily separable for sterilization by immersion in a sterilizing fluid. The power source in the case may be charged through same electrical penetrating element. The membrane comprises a perimeter that is attached and sealed to the case, a penetration area penetrated by the rigid weight-bearing element, and an isolating compliance area. The skirt on upper module protects detritus from entering from below onto the membrane, while providing open-air movement.

Abstract: A sterilization cabinet, comprising a top panel, at least two side panels, and a floor panel forming a part of a chamber of the sterilization cabinet; at least one door connected to at least one of the at least two side panels of the sterilization cabinet; a vent formed in at least one of the two side panels; at least one first filter covering the vent and a filter cover configured to hold the first filter against the vent; a drain positioned in the floor panel, wherein the floor panel has a slope configured to cause condensate within the chamber to flow into the drain and wherein the drain is the only outlet for the condensate along the floor panel; and a second filter covering the drain such that condensate flowing into the drain passes through the second filter.

Abstract: An electrical wall socket mounted aromatic gas emitting device includes an air bearing seat, a fragrance bottle mounted in the air bearing seat and having a volatile carrier partially inserted into the bottle mouth thereof to absorb the fluid fragrance for dissipation into outside open space, a gas delivery device for continuously delivering air to the air bearing seat so that the air bearing seat can guide the flow of air to flow along the surface of the volatile carrier for agitate the fluid fragrance to emit fragrance smell.

Abstract: A wall socket mounted solid fragrance aroma diffuser includes a bottom housing, an electrical plug assembly mounted in the bottom housing at one side, an air bearing seat mounted in the bottom housing, an air delivery device mounted inside the bottom housing and electrically coupled to the electrical plug assembly and adapted for creating a flow of air through the air bearing seat, and breathable fragrance capsules respectively filled with a solid fragrance material and placed in the air bearing seat in a stack. Each breathable fragrance capsule has vent holes on the opposing top and bottom sides for aroma diffusion so that the breathable fragrance capsule can be placed in the air bearing seat on either of the top and bottom sides, facilitating installation and replacement.

Abstract: A method of promoting hemostasis in the mouth or oral cavity utilizes a non-absorbent, low surface energy and highly conformable non-disruptive hemostasis material. Traditional wound packing material is highly absorbent and has large open surfaces that allow clot forming materials, such as the platelet plug to adhere to the packing material and whereupon removal, the clot is disrupted. A non-disruptive highly conformable hemostasis material does not have large open pores and therefore does not adhere to forming clots. A non-disruptive hemostasis material may consist of expanded polytetrafluoroethylene that has a pore size of no more than about 10 microns. A non-disruptive hemostasis material may comprise a thin film of material over a portion of the outside surface that is non-absorbent and thin to allow for conforming into an oral cavity, such as from a tooth extraction. A thin film may cover porous material, such as a foam, that may be elastomeric.

Abstract: Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

Abstract: The present invention provides a peripheral nerve growth conduit for peripheral nerve repair, in particular conduits through which peripheral nerves can grow. The conduit includes poly-?-caprolactone (PCL). Preferably, the inner (luminal) surface of the conduit comprises pits having a depth of 1-4?m. Suitably, the conduit may also include poly-lactic acid (PLA). The inner surface of the conduit may have been treated with an alkaline composition. The present invention also provides a method for treating a peripheral nerve damage using a peripheral nerve growth conduit including poly-?-caprolactone (PCL). The present invention also provides a kit for treating a peripheral nerve damage having a peripheral nerve growth conduit including poly-?-caprolactone (PCL).

Abstract: The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

Abstract: A transplant product derived from human umbilical cord has a collagenous tissue membrane derived from an umbilical cord, configured as a soft tissue barrier or wound covering or other internal or external wound healing attachment. The structural, chemical and biochemical properties are retained, the collagenous tissue membrane is cleaned removing the veins, arteries and Wharton's jelly without exposure to harsh chemicals. The collagenous tissue membrane is soaked in normal saline solution under mild agitation for a predetermined time to structurally increase tear resistance of the membrane. The collagenous tissue membrane is free of meconium. The collagenous tissue membrane has a general transparent or translucent appearance of a clear or slightly pink color. In one embodiment, the transplant product has one or more suture entry sites to facilitate suturing the product to tissue.

Abstract: Tissue scaffolds are described herein. Also described are devices for treating wounds and methods of treating wounds using tissue scaffolds.

Abstract: A sterile composition for intraepidermal, intradermal, and/or subcutaneous administration including an effective amount of hyaluronic acid or a salt thereof, the effective amount of hyaluronic acid or salt thereof ranging from 1 to 3 wt % of the overall weight of the sterile composition, mepivacaine or a salt thereof as a first anesthetic agent at a concentration ranging from 0.05 to 3 wt % of an overall weight of the sterile composition, and a balanced salt solution in which the sterile composition exhibits greater stability over time and/or during heat treatment resulting in sterilization in comparison to the same composition having lidocaine as the anesthetic agent instead of mepivacaine.

Abstract: Provided are surface-modified rubbers or surface-modified thermoplastic elastomers, such as catheters, syringe barrels, tubes of medical instruments, and mudguard fenders, and methods for modifying the surface of rubber or a thermoplastic elastomer, wherein a lubricant layer is firmly bonded to the surface of medical devices such as catheters, syringe barrels, and tubes of medical instruments to impart lubricity to the surface and, further, improve the durability of the lubricant layer on the surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified rubber or a surface-modified thermoplastic elastomer each having a surface at least partially treated by polymerization of a monomer in the presence of a thermal polymerization initiator.

Abstract: One aspect relates to a composite, including a ceramic body having a first layer surface and a second layer surface and at least one cermet conductor that electrically connects the surfaces. The composite includes a first layer with the first layer surface, a first ceramic, a first hole and a first cermet element in the first hole, a second layer with the second layer surface, a second ceramic, a second hole and a second cermet element in the second hole, and an intermediate layer that is located between the first and the second layer. The intermediate layer includes an intermediate layer ceramic, an intermediate hole and one intermediate cermet element in the intermediate hole. A projection of the cross-section of the first hole and a projection of the cross section of the second hole onto a plane Px,y are arranged offset to each other.

Abstract: A method of incorporating silver and/or copper into a biomedical implant includes: providing an implant having an outer surface; depositing silver and/or copper onto the outer surface of the implant; diffusing the silver and/or copper into a subsurface zone adjacent the outer surface; and oxidizing or anodizing the implant after the diffusion step to form an oxidized or anodized layer that contains at least some amount of elemental silver, elemental copper or silver or copper ions or compounds.

Abstract: Provided is a suction device that can suppress sound and vibration during use. A suction device includes a flow-passage forming section (1) having a suction port (20) from which fluid is sucked, a discharge port (29) from which the fluid is discharged, and a flow passage (2) which is sealed from an outside except at the suction port (20) and the discharge port (29) and through which the fluid flows, and a piezoelectric driving part (33) that generates a flow of the fluid in the flow passage (2). The piezoelectric driving part (33) includes a diaphragm (37) and a piezoelectric element (34) as a moving part that transmits driving force to the fluid. The moving part is entirely disposed inside the flow passage (2).

Abstract: A method and system of controlling medical suction is disclosed. The system comprises a vacuum regulator comprising a valve, wherein the first end of the regulator may be fluidly connected to a vacuum source and the second end of the regulator may be fluidly connected to a patient interface. The valve may comprise a small orifice or pathway, allowing fluid to pass from the second end of the regulator to the first end of the regulator while the valve is closed. The system may also comprise a flow detector, wherein the flow detector is capable of sensing when the patient interface is in contact with a liquid and cause the valve to open, thereby allowing full flow of fluids from the second regulator end to the first regulator end.

Abstract: An apparatus includes a housing, a first cannula, and a second cannula. The housing defines an inner volume having a first portion in fluid communication with a first set of openings, and a second portion in fluid communication with a second set of openings and fluidically isolated from the first portion. The first cannula has a proximal end portion fluidically couplable to a vacuum source and a distal end portion coupled to the housing such that the first portion of the inner volume and a lumen defined by the first cannula fluidically couple the first openings to the vacuum source. The second cannula has a proximal end portion fluidically couplable to a fluid source and a distal end portion coupled to the housing such that the second portion of the inner volume and a lumen defined by the second cannula fluidically couple the second openings to the fluid source.

Abstract: An apparatus and method for aspirating, irrigating and/or cleansing wounds is provided. The apparatus and method include one or more of the following: simultaneous aspiration and irrigation of the wound, supplying of thermal energy to fluid circulated through the wound; supplying physiologically active agents to the wound; a biodegradable scaffold in contact with the wound bed; and application of stress or flow stress to the wound bed.

Abstract: When sucking a fluid within a body cavity, foreign matter included in the fluid which exceeds the filtering diameter of a filtering apparatus may cause clogging of the filtering apparatus. Another concern is that a body cavity membrane getting stuck to a suction port of a suction tube may lead to the suction port being closed off. In response to such problems as these, provided is a suction apparatus, comprising a suction tube, and a filter member. The suction tube has side holes formed in a tube wall on a body cavity-side tail end part. The filter member has a tubular cap shape and covers a tail end aperture of the suction tube and the side holes, is formed from a foam body with an average aperture opening of 500-1000 ?m, and has a thickness of 7.5 mm or more.

Abstract: The invention relates to a fluid pump or rotary cutter having at least one first element (9??, 10??) which can be brought from a transport state into an operating state by changing at least one mechanical property. Such a pump can, for example, be a blood pump for the medical, microinvasive area. The object of achieving a transition between the transport state and the operating state which is as comfortable as possible and in so doing leaving a freedom in the design of the corresponding apparatus, in particular of a pump, which is as large as possible, is achieved using the means of the invention in that the first element at least partly comprises a material (24, 25, 26, 27) or can be filled with a material or material mixture which passes through a chemical reaction, in particular cross-linking, or a crystallization for transition into the operating state.

Abstract: A mechanical circulatory support device. The mechanical circulatory support device includes an inner casing defining a fluid flow path, the fluid flow path defines a longitudinal axis. A rotor is mounted within the fluid flow path and configured to rotate about the longitudinal axis. A housing is included, the inner casing and the rotor being substantially disposed within the housing. The housing having a cross-sectional shape in a plane transverse to the longitudinal axis which decreases in thickness extending from a medial position to opposite lateral positions.

Abstract: A method and apparatus for long-term assisting the left ventricle of a heart to pump blood is disclosed which includes at least one transluminally deliverable pump and a transluminally deliverable support structure which secures the at least one pump within the aorta for long-term use.

Abstract: A medical device system includes a medical device configured to be carried by a patient and a plurality of controllers capable of controlling operation of the medical device. Each controller has an active state in which the controller is in communication with, and controls the operation of, the medical device, and a passive state in which the controller is not controlling operation of the medical device. At any given time only one of the plurality of controllers will be in the active state and a remainder of the plurality of controllers will be in the passive state. The active controller may be configured to continually communicate with the remainder of passive controllers, without using the medical device as an intermediary, to update the information stored in the memories of the passive controllers to match the information in the memory of the active controller.

Abstract: A molded interconnect device can carry a Hall sensor for transducing a position of a rotor of the implantable blood pump. The molded interconnect device includes one or more integrated electronic circuit traces configured to electrically connect the hall sensor with a printed circuit board of the implantable blood pump, and the molded interconnect device is configured to be mounted to the printed circuit board.

Abstract: A TET system is operable to vary an amount of power transmitted from an external power supply to an implantable power unit in accordance with a monitored condition of the implantable power unit. The amount of power supplied to the implantable power unit for operating a pump, for example, can be varied in accordance with a cardiac cycle, so as to maintain the monitored condition in the power circuit within a desired range throughout the cardiac cycle.

Abstract: Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

Abstract: A fluid processing cassette and sensor coupling system is disclosed, comprising a cassette comprising a cap having an opening formed by an inner cylindrical wall having a first diameter, an outer cylindrical wall having a second diameter, and a contact surface connecting the inner and outer cylindrical walls. The contact surface includes a varying diameter that decreases from the second diameter to the first diameter. A sensor post comprises a ring disposed around a cylindrical body and is positioned to engage with the contact surface of the cap to form a seal.

Abstract: Renal failure therapy system includes a blood filter, a blood pump, a dialysis fluid pump, a blood line connecting to a patient, a transmitter for receiving a transmit signal and transmitting a wave into blood flowing through the blood line, a receiver for receiving the wave and emitting a corresponding received signal, and a processor for initiating the transmit signal and for receiving the received signal, configured to convert the transmit and received signals into a frequency domain, extract spectral values for the converted transmit and received signals, calculate at least one of a reflection coefficient (R) or an impedance ratio (I) using the spectral values, and analyze an imaginary part of at least one of R or I to determine if an access disconnection event concerning fluid communication between the blood line and the patient has occurred.

Abstract: An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line operational mode where the oxygen supply unit is being powered by battery only, a larger flow of recycled gas from the blood oxygenator is passed through the carbon dioxide scrubber and combined with a lesser amount of oxygen-rich gas from the oxygen concentrator. The oxygen supply unit may be used in combination with a blood pump and oxygenator to provide ambulatory blood oxygenation to patients with compromised lung function.

Abstract: An infusion management system includes an infusion management server configured for providing an order to an infusion device to administer an infusion and the infusion device. The infusion device may be configured for receiving the order, associating the order with a patient, and adjusting at least one setting according to the order. A method for administering an infusion, an interface for an infusion device and a computer program product are also disclosed.

Abstract: The present invention refers to a medical device for trans-dermal infusion of a medicament comprising a reservoir for holding a medicament to be infused, a pump for pumping medicament from the reservoir, wherein the device is assembled or adapted to be assembled in at least one pre-operational arrangement with or without the reservoir and is adapted to be rearranged from the at least one pre-operational arrangement into an operational arrangement comprising the reservoir. In particular, in the pre-operational arrangement without reservoir the pump is in a mechanically distressed condition preventing functional operation of the pump, and in the pre-operational arrangement comprising the reservoir the pump is in a mechanically distressed condition preventing functional operation of the pump and/or the reservoir is fluidically disconnected from the pump.

Abstract: A system for delivering fluid to a user transcutaneously includes a subcutaneous infusion cannula base assembly, a cannula inserter assembly and a fluid connection assembly. The subcutaneous infusion cannula base assembly is configured to be located on the user's skin. The cannula inserter assembly is coupled to the cannula base assembly and is configured to drive an infusion cannula through the user's skin in a nominally helical trajectory. The fluid connection assembly is configured to fluidically connect the cannula base assembly to a source of delivery fluid. Cannula and stylet assemblies configured for helical or non-helical insertion are also disclosed.