Patents Issued in October 29, 2019
  • Fuel compositions
    Patent number: 10457881
    Abstract: Low sulphur marine fuel compositions are provided. Embodiments comprise greater than 50 to 90 wt % of a residual hydrocarbon component comprising at least one of an atmospheric tower bottoms (ATB) residue and a vacuum tower bottoms residues (VTB), wherein the residual hydrocarbon component has a kinematic viscosity at ˜50 degrees C. of at least 100 cSt; and at least 10 and up to 50 wt % of a non-hydroprocessed hydrocarbon component comprising deasphalted oil (DAO), where the marine fuel composition has a kinematic viscosity at ˜50 degrees C. of at least 10 cSt. Embodiments of the marine fuel composition can have a sulphur content of about 0.1 wt % or less.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: October 29, 2019
    Assignee: SHELL OIL COMPANY
    Inventors: Danny F. Droubi, Michael Allen Branch, Cynthia Delaney-Kinsella, Dana Tatum Lipinsky, Lawrence Stephen Kraus, Tommy Louis Brumfield, Ariel Bru, Koen Steernberg, Pierre Tardif, Shannon Boudreaux
  • Methods of producing solid fuel using low ash, low sulfur coal replacement from fast pyrolysis of biomass
    Patent number: 10457882
    Abstract: The present invention is directed to a method of producing a solid fuel which includes providing a bio-oil and thermally curing the bio-oil to form a carbonaceous solid. The present invention is also directed to a method of producing a solid fuel which includes providing a bio-oil; subjecting the bio-oil to an extraction procedure with an aqueous liquid to produce a concentrated pyrolytic sugar-containing extract and a water insoluble raffinate comprising a lignin-derived phenolic oil; and thermally curing the phenolic oil to form a carbonaceous solid.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Robert C. Brown, Marjorie Rover, Andrew J. Friend, Ryan G. Smith
  • Method of separating and de-watering fine particles
    Patent number: 10457883
    Abstract: A process for cleaning and dewatering hydrophobic particulate materials is presented. The process is performed in in two steps: 1) agglomeration of the hydrophobic particles in a first hydrophobic liquid/aqueous mixture; followed by 2) dispersion of the agglomerates in a second hydrophobic liquid to release the water trapped within the agglomerates along with the entrained hydrophilic particles.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 29, 2019
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventor: Roe-Hoan Yoon
  • Mixed detergent composition for intake valve deposit control
    Patent number: 10457884
    Abstract: A detergent additive package, fuel additive concentrate, fuel composition and method for operating an engine on an unleaded gasoline fuel. The additive package includes a Mannich base detergent mixture, wherein the mixture contains a first Mannich base detergent component derived from a di- or polyamine and a second Mannich base detergent component derived from a monoamine. A weight ratio of the first Mannich base detergent to the second Mannich base detergent in the mixture ranges from about 1:6 to about 3:1.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: October 29, 2019
    Assignee: Afton Chemical Corporation
    Inventors: Joseph M. Russo, William Jay Colucci
  • Coating film, manufacturing method for same, and PVD device
    Patent number: 10457885
    Abstract: Provided are a coating film, a manufacturing method for the same, and a PVD device that not only sufficiently improve the balance of low-friction properties and wear resistance, but also improve chipping resistance and peeling resistance. This film is coated on a substrate surface, wherein the coating film has a hard carbon that presents relatively black and white when observed in a cross-sectional bright-field TEM image, a mesh-shaped hard carbon layer is formed using a PVD method, said layer having white-colored hard carbon in a mesh shape extending in the thickness direction and black-colored hard carbon dispersed into the cavities in the mesh, and the ID/IG ratio is 1-6 when the mesh-shaped hard carbon layer is measured using Raman spectroscopy, said ratio being the ratio of the Raman spectrum D band peak area intensity and G band peak area intensity.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: October 29, 2019
    Assignees: NIPPON ITF, INC., NIPPON PISTON RING CO., LTD.
    Inventors: Hideki Moriguchi, Tadashi Saito, Yoshikazu Tanaka, Akinori Shibata, Tetsumi Arahi, Katsuaki Ogawa, Takahiro Okazaki, Hiroyuki Sugiura, Yoshihiro Ito
  • Catalytic depolymerisation of polymeric materials
    Patent number: 10457886
    Abstract: A process for converting a molten polymeric material is provided. The process includes effecting disposition of a molten polymeric material, having at least one carbon-carbon double bond, in sufficient proximity to a catalyst material within a reaction zone, to affect a reactive process that effects generation of a reaction product. The reactive process effects cleaving of at least one carbon-carbon double bond. The catalyst material includes [Fe—Cu—Mo—P]/Al2O3 prepared by binding a ferrous-copper complex to an alumina support to generate an intermediate material and reacting the intermediate material with a heteropolyacid.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 29, 2019
    Assignee: GreenMantra Recycling Technologies Ltd.
    Inventors: Anil Kumar, Pushkar Kumar
  • Trunk piston engine oil composition
    Patent number: 10457887
    Abstract: A low sulfur marine distillate fuel trunk piston diesel engine lubricating oil composition comprising (a) a major amount of a Group I base oil or a Group II base oil or mixtures thereof; (b) at least one or more detergents comprising at least one overbased salt of an alkyl-substituted hydroxybenzoic acid; and (c) a succinimide dispersant derived from polyalkylene having a number average molecular weight (Mn) of 1400-3000; wherein the succinimide dispersant is present at greater than 1.20 wt. % on an actives basis; and the TBN of the composition is less than 30 mg KOH/g.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: October 29, 2019
    Assignee: CHEVRON ORONITE TECHNOLOGY B.V.
    Inventor: Wilhelmus Petrus Antonie van Houten
  • Lubricating members for razor cartridges
    Patent number: 10457888
    Abstract: The invention relates to a lubricating member for a razor cartridge comprising a lipophilic structurant and a silicone polyether block copolymer and optionally a liquid phase, which can be manufactured in a simple one batch process without thermal degradation and exhibiting improved lubricating and skin care properties over a sustained period.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: October 29, 2019
    Assignee: Braun GMBH
    Inventors: Alison Fiona Stephens, Poppy Clea Reese
  • Low-temperature treated perilla oil for suppressing generation of coagulated suspended materials during low-temperature cold storage and preparation method therefor
    Patent number: 10457889
    Abstract: The present invention relates to a low-temperature treated perilla oil for suppressing generation of coagulated suspended materials during low-temperature cold storage and a preparation method therefor, and more particularly, to a low-temperature treated perilla oil for suppressing generation of coagulated suspended materials during low-temperature cold storage and a preparation method therefor, wherein in the low-temperature storage and cold storage of perilla oil, which are essentially implemented to increase the storage period of the perilla oil through the minimization of rancidity of the perilla oil, a perilla oil without the generation of coagulated suspended materials during low-temperature cold storage is provided, and thus a high-quality clean perilla oil that does not give an eating person an unpleasant feeling due to suspended materials is provided.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: October 29, 2019
    Assignee: Soobook LIM
    Inventor: Soobok Lim
  • Phospholipase C
    Patent number: 10457890
    Abstract: The present invention relates to a polypeptide having phospholipase C activity, selected from the group consisting of i. a polypeptide comprising a mature polypeptide sequence of SEQ ID NO: 2; ii. a polypeptide that has least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to the mature polypeptide sequence of SEQ ID NO: 2; iii. a polypeptide encoded by a nucleic acid that hybridizes under medium stringency, preferably under high stringency conditions to the complementary strand of the mature polypeptide coding sequence of SEQ ID NO:1; iv. a polypeptide encoded by a nucleic acid that has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to the mature polypeptide coding sequence of SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: October 29, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Arjen Sein, Rene Marcel De Jong, Evert Tjeerd Van Rij, Willem Bijleveld, Maarten Hotse Wilbrink
  • Organic compounds
    Patent number: 10457891
    Abstract: An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal care and household care products.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: October 29, 2019
    Assignee: Givaudan S.A.
    Inventors: Andreas Goeke, Philip Kraft, Heike Laue, Yue Zou, Francis Voirol
  • Fatty acid ester-based wax compositions and methods of making thereof
    Patent number: 10457892
    Abstract: This invention relates to a wax composition comprising one or more fatty acid diester compounds having the formula of R1 and R2 are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; and n1 is an integer from 2 to 10. This invention also relates to a wax composition comprising: a) one or more fatty acid monoester or diester compounds having the formula of: and b) one or more hydroxylated fatty acid diester compounds having the formula of In these formulae, R is H or COR1?; R1? and R2? are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; n2 is an integer from 2 to 24; m is an integer from 2 to 12; and .(OH)m represents 2 to 12 hydroxyl groups substituting for 2 to 12 hydrogen atoms in the alkyl groups R1? and/or R2?. Uses of the compositions are also disclosed.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Tong Wang, Tao Fei
  • Process of washing fabrics that have a softening active deposited thereon
    Patent number: 10457893
    Abstract: The present disclosure relates to a process of washing fabrics where the fabrics have a softening active deposited thereon. It also relates to the use of a liquid laundry detergent composition used in the described process.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: October 29, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Colin Ure, Alan Thomas Brooker, Samantha Jane Martell
  • Color-protecting detergent or cleaning agent having an optical brightener
    Patent number: 10457894
    Abstract: The application describes a water-soluble packaging having at least two chambers and containing a first liquid detergent or cleaning agent with a low content of water, a second liquid detergent or cleaning agent with a low content of water and a water-soluble wrapping, the first liquid detergent or cleaning agent with a low content of water containing an optical brightener and the second liquid detergent or cleaning agent with a low content of water containing a color transfer inhibitor.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: October 29, 2019
    Assignee: Henkel AG & Co. KGaA
    Inventors: Frank Meier, Sabine Schuemann, Thorsten Ott, Luca Bellomi, Matthias Sunder
  • Washing or cleaning agent for reducing malodors
    Patent number: 10457895
    Abstract: A washing or cleaning agent that has MOFs (metal organic frameworks) in order to reduce offensive odor, a method for reducing malodors, and the use of MOFs to reduce malodors.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 29, 2019
    Assignees: Henkel AG & Co. KGaA, Technische Universität Dresden Fachbereich Anorganische Chemie I
    Inventors: Christian Kropf, Matthias Sunder, Ursula Huchel, Peter Schmiedel, Marc Weyhe, Stefan Kaskel, Anja Guenther, Steffen Hausdorf
  • Dry and portable spot removal product and method comprising an aluminum dioctahedral phyllosilicate
    Patent number: 10457896
    Abstract: A stain removal product formulation and method utilizing a dry, portable product. The dry, portable removal product preferably contains specially treated ingredients, including a composition of microporous silica and alumina tetrahedra and combined with aluminum dioctahedral phyllosilicales family of minerals, ingredients may vary depending on the type of stain to treat, for example, for stains having an oil. grease or fat base. Due to the nature of stains and their varied content the product formulation may also include a combination of other dry ingredients such as clays, minerals, baking soda, com stareh, flour or other dry ingredients. Optional ingredients which may be added including dry coloring and/or dry fragrance components. The dry product formulation is provided in a powder, granule or flake form in moisture resistant packages and kits.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: October 29, 2019
    Assignee: Spot Stuff, Inc.
    Inventor: Milissa Nelson
  • Liquid laundry detergent composition comprising a first polymer and a second polymer
    Patent number: 10457897
    Abstract: Liquid laundry detergent compositions comprising a first and second polymer. Water-soluble unit dose articles containing such compositions. Related methods.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 29, 2019
    Assignee: The PRocter & Gamble Company
    Inventors: Carly Pickering, Alan Thomas Brooker, Nigel Patrick Somerville Roberts, Colin Ure
  • Liquid detergent composition comprising cellulosic polymers and cellulase
    Patent number: 10457898
    Abstract: Liquid laundry detergent compositions comprising a first and a second cellulosic polymer and a cellulase. Related methods.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 29, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Carly Pickering, Alan Thomas Brooker, Nigel Patrick Somerville Roberts, Colin Ure
  • Polyfunctional polymers based on phosphonate units and amine units
    Patent number: 10457899
    Abstract: The invention relates to polyfunctional polymers suitable in particular for the treatment of metal surfaces (metal finishing) and comprising: monomer units u1 bearing phosphonic acid functions; monomer units u2 bearing amine functions; and optionally monomer units u3 bearing alcohol units —OH.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: October 29, 2019
    Assignee: RHODIA OPERATIONS
    Inventors: Inigo Gonzalez, Marie-Pierre Labeau, Gary Woodward
  • Detergent composition comprising an alkyl ether sulfate-rich surfactant system and coated encapsulates
    Patent number: 10457900
    Abstract: Liquid detergent compositions having a surfactant system and encapsulates, where the surfactant system includes anionic alkoxylated alkyl sulphate surfactant. Methods of making and using such detergents.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 29, 2019
    Assignee: The Proctor & Gamble Company
    Inventors: Renae Dianna Fossum, Gregory Thomas Applegate, Anne Compton Rodrigue
  • Cleaning composition, method of making and use thereof
    Patent number: 10457901
    Abstract: A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 29, 2019
    Assignees: Morehouse School of Medicine, DevMar Products, LLC, Innovative Environmental Companies
    Inventors: Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr.
  • Solid tablet unit dose oven cleaner
    Patent number: 10457902
    Abstract: A solidification matrix includes sodium hydroxide, sodium carbonate, a water charge, an anhydrous metasilicate, a polycarboxylic acid polymer or salt or derivative thereof, and additional functional ingredients. The sodium hydroxide, sodium carbonate, a water charge, an anhydrous metasilicate, a polycarboxylic acid polymer, and additional functional ingredients interact to form a hydrate solid. The solidification matrix may be used, for example, in a solid detergent composition. Methods of making solid detergent compositions are disclosed.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: October 29, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Caleb Jones, Katherine Molinaro, Darryl Bowling, Karen Rigley, Brenda Lynn Tjelta, Lisa Maureen Sanders, Michael Edward Besse
  • Tank for wine fermentation
    Patent number: 10457903
    Abstract: The tank comprises a cylindrical vessel, air tight sealing means, pressure control means, and in addition: a first gas adduction nozzle, located in proximity of the bottom of the cylindrical vessel; a second gas adduction nozzle, provided at an intermediate height of the cylindrical vessel; a third gas adduction nozzle, provided in the upper part of the cylindrical vessel, above the maximum level reached by the liquid; power and control means, functionally connected to the pressure control means, first, second and third gas adduction nozzles, adapted to determine for the same respective predetermined operative phases, in order to perform vinification processes with controlled oxidation, even without the addition of sulphites. The tank is advantageously equipped with organs for taking the must from the bottom and spreading it from the top, by up-down shaking, activated by the power and control means.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: October 29, 2019
    Assignee: U.G.C. SAS DI GHIDI PIETRO & C.
    Inventors: Pietro Ghidi, Marco Ghidi, Pier Paolo Ghidi
  • Miniaturized continuous-flow fermenting apparatus
    Patent number: 10457904
    Abstract: A system, method, and apparatus for the fermentation of a beverage by use of continuous flow is provided. The fermented beverage can be any of a wine, beer, mead, ale, soda, cider, or other. The invention provides for small-scale fermentation that can be done in a much shorter time than previous batch fermentations. The small-scale and shortened time allows for variables to be introduced and tested to produce new varieties, flavors, qualities, and other combinations that are inputs of the fermented beverage.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Daniel Attinger, Liang Dong, Yuncong Chen
  • Bioreactor connectors
    Patent number: 10457905
    Abstract: Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.
    Type: Grant
    Filed: March 15, 2014
    Date of Patent: October 29, 2019
    Assignee: Biostage, Inc.
    Inventor: Herbert Hedberg
  • Method for the effective delivery of photonic energy to cultures in a fluid medium
    Patent number: 10457906
    Abstract: An apparatus to prevent bio-filming during the delivery of photonic energy to a culture or set of organisms in a fluid culture medium, the device including a culture medium, a container configured to house the culture medium, and an assembly to generate and deliver a liquid energy transfer medium between the culture medium and the photonic device, the assembly including one or more apertures sized and shaped to form one or more liquid replenishing lenses and a fluid-light unit in the container to house the photonic device and the liquid energy transfer medium, the photonic device is at least one from among a photoreceptor, a photoemitter, or a combination of the photoreceptor and the photoemitter, and further including a pump coupled to the fluid-light unit, the assembly is configured to convey the photonic energy between the photonic device and the culture medium through the liquid energy transfer medium.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: October 29, 2019
    Assignee: Staterra LLC
    Inventors: Jared P. Green, Eric R. Brooks
  • Electrochemical measurement device
    Patent number: 10457907
    Abstract: An electrochemical measurement device includes: a base; a specimen placement portion disposed on the base, for placing a biological specimen; a first electrode disposed on the base and surrounding the specimen placement portion; and a first insulating layer covering the first electrode. The first insulating layer has a plurality of openings, and the first electrode has a plurality of first electrode exposed portions which are portions of the first electrode that are exposed from the openings of the first insulating layer.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: October 29, 2019
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Atsushi Shunori, Masahiro Yasumi, Makoto Takahashi
  • Method of microbiological analysis of a sample in a unique container
    Patent number: 10457908
    Abstract: The present invention relates to a method of analysis comprising the preparation and the analysis of a sample in a flexible container without direct handling of the sample and without reopening the flexible container at the end of the preparation of the sample, and also to a container and a kit that enable the implementation of this method.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: October 29, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, PRESTODIAG, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Roberto Calemczuk, David Carrara, Thierry Livache, Thibaut Mercey, Félix Piat, Yoann Roupioz, Sami Slimani
  • High yield algal biomass production without concentrated COsupply under open pond conditions
    Patent number: 10457909
    Abstract: Methods and systems for efficient culturing of algae in open ponds. Further, the methods include a method for culturing algae in an open pond medium that is free of any concentrated supply of CO2, and no concentrated source of CO2 is used to supply carbon for culturing the algae. Also, the algae are cultured in the open pond which has a pH above 9.5. In addition, the open pond medium has incorporated therein an inorganic carbon buffer at a specified concentration under conditions for obtaining an increased biomass. Also, the pH above 9.5 permits sufficient increased fixation of atmospheric CO2 into the open pond medium.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 29, 2019
    Assignee: The University of Toledo
    Inventors: Brahmaiah Pendyala, Agasteswar Vadlamani, Sridhar Viamajala, Sasidhar Varanasi, Mohammadmatin Hanifzadeh
  • Method for deep dehydration and desiccation of cyanobacteria
    Patent number: 10457910
    Abstract: A method for deep dehydration and desiccation of cyanobacteria includes steps of flocculation conditioning, high pressure diaphragm plate-frame pressure filtration, quartz glass box-type desiccation and negative pressure paddle drying.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: October 29, 2019
    Assignee: JIANGSU PROVINCIAL ACADEMY OF ENVIRONMENTAL SCIENCE
    Inventors: Bo Bian, Binbin Fang, Lingjun Zhou, Haisuo Wu, Qin Zhang, Weili Jiang, Wei Cheng, Yamin Fan
  • Medium for stem cell use
    Patent number: 10457911
    Abstract: Culture media which contain a water-soluble polymer, such as polyvinyl alcohol and the like, and albumin, and the like, are useful for the proliferation of stem cells, and show good culture results, particularly with iPS cells, and maintain the stability of the medium properties, as well as using a reduced amount of albumin.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 29, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventors: Yoko Kuriyama, Satoru Okamoto, Manabu Kitazawa, Nao Sugimoto, Takuya Matsumoto
  • Stromal vascular fraction processing devices and methods
    Patent number: 10457912
    Abstract: Disclosed herein are systems, devices and methods for processing tissue, such as autologous tissue. Implementations of a Stromal Vascular Fraction (SVF) system are described that can isolate and wash harvested cells contained within various tissues, such as isolate and wash stem cells from fat tissue. The SVF system can minimize the handling and transferring of tissue and fluids, including minimizing the number of human interventions and manipulations required throughout processing. The SVF system can ensure sterility of processed tissue and harvested cells, as well as significantly reduce cost and time associated with the processing.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: October 29, 2019
    Inventors: Philip J. Simpson, David G. Matsuura, Darryl D'Lima, Daniel Kincade
  • Corneal epithelioid cells derived from surface ectodermal cells
    Patent number: 10457913
    Abstract: The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically, the present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell, comprising introducing PAX6, KLF4, and OCT4 into a surface ectoderm-derived cell, such as an oral mucosal epithelial cell, and a corneal epithelioid cell induced by the method.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 29, 2019
    Assignee: Osaka University
    Inventors: Kohji Nishida, Yuzuru Sasamoto, Ryuhei Hayashi
  • Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
    Patent number: 10457914
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: October 29, 2019
    Assignee: Katholieke Universiteit Leuven
    Inventors: Karen Pauwelyn, Catherine M. Verfaillie
  • Chemical differentiation of pluripotentstem cells into retinal epithelial cells
    Patent number: 10457915
    Abstract: The present invention is based in part on a chemically defined method of generating retinal epithelial cells and retinal pigmented epithelial cells from human pluripotent stem cells (hpSCs). The present invention also provides methods and kits for treating degenerative eye disorders.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: October 29, 2019
    Assignee: International Stem Cell Corporation
    Inventors: Russell A. Kern, Rodolfo Gonzalez
  • Method for inducing differentiation of insulin-producing cells
    Patent number: 10457916
    Abstract: It is an object of the present invention to provide a method for efficiently directing differentiation into insulin-producing cells in a xeno-free culture system.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: October 29, 2019
    Assignee: Tokyo Institute of Technology
    Inventors: Shoen Kume, Nobuaki Shiraki
  • Methods for reprogramming somatic cells
    Patent number: 10457917
    Abstract: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: October 29, 2019
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Rudolf Jaenisch, Konrad Hochedlinger
  • Tyrosine hydroxylase variants and methods of use thereof
    Patent number: 10457918
    Abstract: The present disclosure provides a variant tyrosine hydroxylase that provides for increased production of L-DOPA in a host cell that expresses the tyrosine hydroxylase. The present disclosure provides nucleic acids encoding the variant tyrosine hydroxylase, and host cells genetically modified with the nucleic acids. The present disclosure provides methods of making L-DOPA in a host cell. The present disclosure provides methods of making a benzylisoquinoline alkaloid (BIA), or a BIA precursor. The present disclosure provides methods of detecting L-DOPA level in a cell. The present disclosure provides methods of identifying tyrosine hydroxylase variants that provide for increased L-DOPA production; and methods of identifying gene products that provide for increased tyrosine production.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: October 29, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, VALORBEC S.E.C.
    Inventors: Vincent J. J. Martin, Lauren Narcross, John E. Dueber, William C. DeLoache, Zachary N. Russ, P. James Scrivens
  • Feedback-resistant acetohydroxy acid synthase variant and method for producing L-valine using the same
    Patent number: 10457919
    Abstract: The present disclosure relates to an acetohydroxy acid synthase variant in which the feedback inhibition to L-valine is released, a polynucleotide encoding the acetohydroxy acid synthase variant, an expression vector including the polynucleotide, a microorganism producing L-valine including the acetohydroxy acid synthase variant, and a method for producing L-valine using the microorganism.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: October 29, 2019
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Ae Ji Jeon, Byeong Cheol Song, Jong Hyun Kim, Hye Won Kim, Ji Hye Lee
  • Stabilized humicola lanuginosa lipase variants in water-soluble films
    Patent number: 10457920
    Abstract: The invention relates to a lipase containing water-soluble film, and a detergent pouch formed by the water-soluble film.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: October 29, 2019
    Assignees: MONOSOL LLC, Novozymes A/S
    Inventors: Victor Casella, Thomas Hoenger Callisen, Tue Rasmussen, Lise Munch Mikkelsen, Ole Simonsen
  • Lipase variants and polynucleotides encoding same
    Patent number: 10457921
    Abstract: The present invention relates to a variant of a parent lipase, wherein said variant has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, has lipase activity, comprises a substitution at a position corresponding to position 92 and/or 96; and remains unaltered at the positions corresponding to positions 231, 233 and 254 of SEQ ID NO: 2. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 29, 2019
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Jesper Vind, Lone Baunsgaard, Jakob Skjold-Joergensen, Vikram Kjoeller Bhatia, Lars Henrik Oestergaard
  • Engineered cascade components and cascade complexes
    Patent number: 10457922
    Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: October 29, 2019
    Assignee: Caribou Biosciences, Inc.
    Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
  • Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
    Patent number: 10457923
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: October 29, 2019
    Assignees: Novozymes A/S, Novozymes, Inc.
    Inventors: Kirk Schnorr, Tarana Shaghasi
  • Variant maltohexaose-forming alpha-amylase variants
    Patent number: 10457924
    Abstract: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 29, 2019
    Assignee: DANISCO US INC
    Inventors: Luis G. Cascao-Pereira, David A. Estell, Marc Kolkman, Harm Mulder
  • Process for the production of cellulolytic and/or hemicellulolytic enzymes
    Patent number: 10457925
    Abstract: The process for the production of cellulolytic and/or hemicellulolytic enzymes by a cellulolytic and/or hemicellulolytic microorganism according to the present invention comprises at least one phase for growth in the presence of a source of carbon and at least one phase for production in the presence of an inducing substrate, in which said inducing substrate is a mixture comprising 40% to 65% by weight of glucose or cellulosic hydrolysates, 21% to 25% by weight of lactose and 10% to 39% by weight of xylose or a solution of a lignocellulosic hemicellulosic hydrolysate, the sum of these three constituents being equal to 100%.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: October 29, 2019
    Assignee: IFP ENERGIES NOUVELLES
    Inventors: Fadhel Ben Chaabane, Frederic Monot
  • Polypeptides having xylanase activity with a high conversion rate of xylose—containing polysaccharides
    Patent number: 10457926
    Abstract: The present application provides novel polypeptides having xylanase activity and the respective nucleic acid sequences encoding those polypeptides as well as vectors comprising these nucleic acid sequences and host cells transformed by these vectors. In addition the present invention provides a method for producing these polypeptides and a composition comprising the inventive polypeptides.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: October 29, 2019
    Assignee: Clariant Produkte (Deutschland) GmbH
    Inventors: Christoph Reisinger, Christian Gamauf, Michael Kraus, Isabel Unterstrasser, Aleksandra Mitrovic, Anton Glieder
  • Multiprotease therapeutics for chronic pain
    Patent number: 10457927
    Abstract: The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In preferred embodiments, the invention includes methods and compositions for the treatment of inflammatory disorders (such as arthritis); chronic pain, such as neuropathic pain and inflammatory pain through the use of such Clostridial neurotoxin derivatives, including those derived from an intact BoNT/A having an LC/E-derived endopeptidase joined to the LC/A endopeptidase.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: October 29, 2019
    Assignee: Dublin City University
    Inventors: James Oliver Dolly, Jiafu Wang, Jianghui Meng
  • Protease variants having an improved washing performance
    Patent number: 10457928
    Abstract: The disclosure relates to proteases, the amino acid sequence of which has been modified in particular with regard to the use thereof in detergents and cleaning agents, all sufficiently similar proteases having a corresponding modification and nucleic acids coding for them. The disclosure further relates to methods and uses of said proteases and to agents containing them, in particular detergents and cleaning agents.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 29, 2019
    Assignee: Henkel AG & Co. KGaA
    Inventors: Hendrik Hellmuth, Thomas Weber, Timothy O'Connell, Susanne Tondera, Brian Laufs, Ayhan Aydemir, Claudia Lindner
  • Compositions for the treatment of gluten intolerance and uses thereof
    Patent number: 10457929
    Abstract: The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain (or a biologically active fragment, analogue or variant thereof) alone or in combination with other suitable enzymes including bromelain, and/or an intestinal extract, as herein described. The present invention also provides methods of using such compositions for the prophylaxis or treatment of a condition arising from gluten intolerance.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: October 29, 2019
    Assignee: Glutagen Pty Ltd.
    Inventors: Teodor Stelmasiak, Hugh James Beatty Cornell
  • Oil-based material-producing method and oil-based material-producing apparatus
    Patent number: 10457930
    Abstract: An oil-based material-producing method includes a microwave irradiation step of irradiating oil-based material-producing microorganisms with microwaves. The oil-based material-producing method may also include a collecting step of collecting an oil-based material produced by the oil-based material-producing microorganisms after the microwave irradiation step.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: October 29, 2019
    Assignees: MICROWAVE CHEMICAL CO., LTD., OSAKA UNIVERSITY
    Inventors: Akinori Ishizuka, Iwao Yoshino, Yasunori Tsukahara