Patents Issued in November 21, 2019
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Publication number: 20190352218Abstract: The invention discloses a composition for preparing glass, a glass article and a use thereof, and a glass article made from the composition. The glass article is preferably a glass substrate made from a composition with an M value of from about 1 to about 10 as calculated by the empirical equation: M=0.13×wt (B2O3)×wt (B2O3)+0.42×wt (CaO)+0.55×wt (MgO)+0.75×wt (SrO)?0.05×wt (Al2O3)×wt (Al2O3). A use of the glass article (especially the glass substrate) for manufacturing a display device is disclosed herein, wherein the glass article has better properties, such as lowered content of solid inclusions and gas inclusions, lowered thickness range and lowered warpage.Type: ApplicationFiled: November 10, 2017Publication date: November 21, 2019Inventors: Debao Li, Qing Li, Guangtao Zhang, Zhonghua Wang, Feng Guo, Dongcheng Yan
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Publication number: 20190352219Abstract: The present invention relates to a glass material for sealing a large-area dye-sensitized solar cell and, more specifically, to a glass material capable of binding to a large area uniformly and very strongly without reacting with en electrolyte. According to the present invention as described above, the glass material is expected to have effects of uniformly sealing a dye-sensitized solar cell, securing stable chemical properties against a reaction with an electrolyte, and having physical strength suitable for large-area binding, and thus can improve reliability and lifetime of solar cell products.Type: ApplicationFiled: July 28, 2017Publication date: November 21, 2019Inventors: Woon Jin CHUNG, Han Sol LEE, Jae Kwun HWANG, Jae Hyoung PARK
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Publication number: 20190352220Abstract: The invention relates to a method for the preparation of a glass ceramic or a glass, which comprise cerium ions and are suitable in particular for the preparation of dental restorations, the fluorescence properties of which largely correspond to those of natural teeth. The invention also relates to a glass ceramic and a glass which can be obtained using the method according to the invention, the use thereof as dental material and in particular for the preparation of dental restorations, as well as a glass-forming composition which is suitable for use in the method according to the invention.Type: ApplicationFiled: July 31, 2019Publication date: November 21, 2019Inventors: Markus Rampf, Sebastian Krolikowski, Christian Ritzberger, Wolfram Höland, Marcel Schweiger
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Publication number: 20190352221Abstract: A glass-ceramic includes glass and crystalline phases, where the crystalline phase includes non-stoichiometric suboxides of titanium, forming ‘bronze’-type solid state defect structures in which vacancies are occupied with dopant cations.Type: ApplicationFiled: August 5, 2019Publication date: November 21, 2019Inventors: Matthew John Dejneka, Jesse Kohl
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Publication number: 20190352222Abstract: A preparation method for a high-refractive index hydrogenated silicon film, a high-refractive index hydrogenated silicon film, a light filtering lamination and a light filtering piece. The method includes: (a) by magnetic controlled Si target sputtering, Si deposits on a base body, forming a silicon film, which (b) forms an oxygenic hydrogenated silicon film in environment of active hydrogen and active oxygen, the amount of active oxygen accounts for 4%-99% of the total amount of active hydrogen and active oxygen, or, a nitric hydrogenated silicon film in environment of active hydrogen and active nitrogen, the amount of active nitrogen accounts for 5%-20% of the total amount of active hydrogen and active nitrogen. Sputtering and reactions are separately conducted, Si first deposits on the base body by magnetic controlled Si target sputtering, and then plasmas of active hydrogen and active oxygen/nitrogen react with silicon for oxygenic or nitric SiH.Type: ApplicationFiled: January 5, 2018Publication date: November 21, 2019Applicant: ZHEJIANG CRYSTAL-OPTECH CO., LTD.Inventors: Ruizhi ZHANG, Jian TANG, Ying WANG, Hui YU, Zhangwu LU, Zhengchi XU, Qibin ZHANG
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Publication number: 20190352223Abstract: The present invention relates to a process for preparing an anti-reflective sol-gel coating composition comprising: a) mixing a hydrolysable silicon alkoxide, (C1-C8)alcohols, an aqueous solution of one acid catalyst; and one or more surfactants of formula (II) wherein: R9 is (C1-C30)alkyl, and m is an integer selected from 2 to 40; the concentration of the surfactant of formula (II) is from 150 to 300 g/L; the molar ratio hydrolysable silicon alkoxide and aqueous solution of acid catalyst is from 0.15 to 1; the molar ratio hydrolysable silicon alkoxide and (C1-C8)alcohol is from 0.15 to 0.30, and molar ratio hydrolysable silicon alkoxide and the surfactant of formula (II) is from 7 to 11.5; b) preparing a second mixture by mixing (C1-C8)alcohols, and an aqueous solution of one acid catalyst; c) adding the second mixture to the mixture of step a); and adding (C1-C8)alcohols until the molar ratio hydrolysable silicon alkoxide and (C1-C8)alcohol is from 0.025 to 0.100 and the composition thus obtained.Type: ApplicationFiled: January 16, 2018Publication date: November 21, 2019Inventors: Cecilia AGUSTIN SAENZ, Oihana ZUBILLAGA ALCORTA, Marta BRIZUELA PARRA
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Publication number: 20190352224Abstract: Provided are: a low-emissivity coating comprising, in sequence, a first lower dielectric layer, a barrier layer, a second lower dielectric layer, a low-emissivity protective layer, a low-emissivity layer, a low-emissivity protective layer, and an upper dielectric layer; and a functional building material for windows and doors comprising the low-emissivity coating.Type: ApplicationFiled: January 13, 2017Publication date: November 21, 2019Inventors: Hyun-Woo YOU, Youn-Ki JUN, Dae-Hoon KWON, Sung-Jin PARK, Young-Woo CHOI
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Publication number: 20190352225Abstract: Laminated glass-based articles and methods of manufacture are disclosed. A glass-based article includes a glass-based substrate having a first surface and a second surface opposing the first surface defining a substrate thickness (t) in a range of about 0.1 millimeters to 3 millimeters, the glass-based substrate having a compressive region having a first compressive stress CS maximum at the first surface of the glass-based article extending to a depth of compression (DOC) and second local CS maximum at a depth of at least 25 ?m from the first surface, wherein the glass-based substrate comprises a glass-based core substrate having a first side and a second side, the glass-based core substrate sandwiched between a glass-based first cladding substrate and a glass-based second cladding substrate, the first cladding substrate and second cladding substrate directly bonded to the first side and the second cladding substrate directly bonded to the second side.Type: ApplicationFiled: January 16, 2018Publication date: November 21, 2019Inventors: Jason Thomas Harris, Vijay Subramanian, Chunfeng Zhou
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Publication number: 20190352226Abstract: A glass-based substrate having a Young's modulus, a first surface, and a second surface. A coating, on at least one of the first and second surfaces, having a Young's modulus equal to or greater than the substrate Young's modulus. A compressive region having a compressive stress CS of from 750 MPa to 1200 MPa at a surface and extending to a depth of compression (DOC). The compressive region having a first portion and a second portion, the first portion extending from the first surface up to a first depth, the second portion extending from the first depth to the DOC, points in the first portion comprise a tangent having a slope that is less than ?15 MPa/micrometers and greater than ?60 MPa/micrometers, and points in the second portion comprise a tangent having a slope that is less than or equal to ?1 MPa/micrometers and greater than ?12 MPa/micrometers.Type: ApplicationFiled: January 31, 2018Publication date: November 21, 2019Inventors: Jason Thomas Harris, Guangli Hu
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Publication number: 20190352227Abstract: A chemically strengthened glass includes a compressive stress layer. A compressive stress is 200 MPa or more at a surface of the chemically strengthened glass. A depth in the compressive stress layer at which the compressive stress is 50 MPa from the surface is 50 ?m or more. A depth in the compressive stress layer at which the compressive stress is 30 MPa from the surface is 60 ?m or more. A critical stress intensity factor KIC is 0.75 MPa·m1/2 or more.Type: ApplicationFiled: August 5, 2019Publication date: November 21, 2019Applicant: AGC Inc.Inventors: Akio Koike, Yusuke Kobayashi
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Publication number: 20190352228Abstract: A glass article having a glass bump formed integrally thereon by laser-irradiation methods. The glass bump includes a lower region connected to an upper region by an inflection region. The lower region projects from a surface of the glass article and is defined by concavely rounded sides with a radius of curvature R1. The upper region includes a transition portion and a top portion. The transition portion is defined by convexly rounded sides with a radius of curvature R2. The transition portion connects to the lower portion via the inflection region. The upper portion connects to the transition portion and is defined by a convexly rounded top surface with a radius of curvature R3, which is greater than radius of curvature R2.Type: ApplicationFiled: July 30, 2019Publication date: November 21, 2019Applicant: Corning IncorporatedInventors: Leonard Thomas Masters, Alexander Mikhailovich Streltsov
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Publication number: 20190352229Abstract: Bitumen which is solid at ambient temperature, in the form of granules including a core made of a first bituminous material and a coating layer made of a second bituminous material, in which: the first bituminous material includes at least one bitumen base and the second bituminous material includes: at least one bitumen base and at least one chemical additive chosen from: an organic compound, a viscosifying compound, a paraffin, a polyphosphoric acid and mixtures thereof; or at least one pitch having a ring-and-ball softening point (RBSP) greater than or equal to 80° C., it being understood that the RBSP is measured according to the EN 1427 standard; or a mixture of these materials.Type: ApplicationFiled: May 22, 2017Publication date: November 21, 2019Applicant: TOTAL MARKETING SERVICESInventors: Mouhamad MOUAZEN, Laurence LAPALU
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Publication number: 20190352230Abstract: A multi-component composition, in particular a three-component composition, especially for manufacture of a polyurethane cementitious hybrid flooring, including or made of: a polyol component (A) including at least one polyol and water; a hardener component (B) including at least one polyisocyanate compound; a solid component (C) including at least one hydraulic binder; and wherein at least one of the components of the multi component composition includes at least one comb polymer having a main chain including acid groups, and side chains being attached on the main chain.Type: ApplicationFiled: July 5, 2017Publication date: November 21, 2019Applicant: SIKA TECHNOLOGY AGInventors: Patricia GIMENO SANTOS, Carola KADDATZ, Jochen GRÖTZINGER
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Publication number: 20190352231Abstract: The present invention refers to a new concrete composition comprising fiberglass waste and an air-entraining additive. The concrete presents a thermo-insulating performance far superior to conventionally produced concretes. The present invention is mainly intended for the construction industry, in non-structural applications for thermal insulation. The use of fiberglass waste reduces the consumption of natural aggregates and allows for the use of waste which is expense to dispose of.Type: ApplicationFiled: May 16, 2019Publication date: November 21, 2019Inventors: Renata Eliane Frank VASCONCELOS, Júlia CASTRO MENDES, Ricardo Andre FIOROTTI PEIXOTO
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Publication number: 20190352232Abstract: Disclosed is a composite gypsum board comprising a board core and a concentrated layer, as well as related methods of preparing board and slurries. The board core and the concentrated layer both are formed from water and stucco. The concentrated layer is designed to have higher density and/or nail pull than the core. The concentrated layer is further formed from one or more of starch thickener, cellulose, and/or copolymer containing polyacrylamide and acrylic acid. In some embodiments, the concentrated layer is formed from an enhancing additive to enhance strength therein, while the core is formed without using enhancing additive or less enhancing additive than used in forming the board core.Type: ApplicationFiled: May 2, 2019Publication date: November 21, 2019Applicant: United States Gypsum CompanyInventors: Qinghua LI, Yijun SANG, Trevor S. RISCHE
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Publication number: 20190352233Abstract: Disclosed is a composite gypsum board comprising a board core and a concentrated layer, as well as related methods of preparing board and slurries. The board core and the concentrated layer both are formed from water and stucco. The concentrated layer is designed to have higher density and/or nail pull than the core. The concentrated layer is further formed from a polysaccharide that forms a complex with calcium ions, e.g., an alginate compound such as sodium alginate. In some embodiments, the concentrated layer is formed from an enhancing additive to enhance strength therein, while the core is formed without using enhancing additive or less enhancing additive than used in forming the board core.Type: ApplicationFiled: May 2, 2019Publication date: November 21, 2019Applicant: United States Gypsum CompanyInventors: Annamaria VILINSKA, Alfred C. Li
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Publication number: 20190352234Abstract: The localized formation of graphene and diamond like structures on the surface of boron carbide is obtained due to exposure to high intensity laser illumination. The graphitization involves water vapor interacting with the laser illuminated surface of boron carbide and leaving behind excess carbon. The process can be done on the micrometer scale, allowing for a wide range of electronic applications. Raman is a powerful and convenient technique to routinely characterize and distinguish the composition of Boron Carbide (B4C), particularly since a wide variation in C content is possible in B4C. Graphitization of 1-3 ?m icosahedral B4C powder is observed at ambient conditions under illumination by a 473 nm (2.62 eV) laser during micro-Raman measurements. The graphitization, with ˜12 nm grain size, is dependent on the illumination intensity. The process is attributed to the oxidation of B4C to B2O3 by water vapor in air, and subsequent evaporation, leaving behind excess carbon.Type: ApplicationFiled: May 3, 2019Publication date: November 21, 2019Inventors: MVS CHANDRASHEKHAR, JOSHUA LETTON, TRAVIS WILLIAMS, ABDULGANIYU AJILORE, MICHAEL SPENCER
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Publication number: 20190352235Abstract: A ceramic-based toughness-enhanced material includes the following starting materials by volume percentage: 92-96% ceramic substrate powder, 2-4% single crystal sapphire fiber, 0.3-0.4% ceramic substrate disperser, 0.6-0.7% single crystal sapphire fiber disperser and 3-5% sintering aid.Type: ApplicationFiled: July 6, 2018Publication date: November 21, 2019Inventors: Renchen LIU, Shishan JI, Yan LIU, Qing MA, Shugang YAN, Xinguo WU
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Publication number: 20190352236Abstract: A pillar-shaped honeycomb structure body of a honeycomb structure includes a circumferential cell structure, a central cell structure and a boundary wall therebetween. On a surface orthogonal to the cells there are a circumferential reinforcing region having the partition wall thicker than a basic partition wall thickness in the circumferential cell structure and existing outside a range of a distance from a centroid of the surface; and at least one of a first boundary reinforcing region having the partition wall thicker than the basic partition wall thickness and existing in a range of a distance from the centroid within a range of the circumferential cell structure and a second boundary reinforcing region having the partition wall thicker than a basic partition wall thickness in the central cell structure and existing outside of a range of a distance from the centroid within a range of the central cell structure.Type: ApplicationFiled: April 16, 2019Publication date: November 21, 2019Applicant: NGK Insulators, Ltd.Inventors: Akifumi KAWAKAMI, Takashi KINOSHITA, Yuji SASAKI, Mitsuhiro ITO
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Publication number: 20190352237Abstract: Provided is a masonry treatment composition containing a fluorine-containing polymer, which contains, as essential components, a fluorine-containing monomer having a fluoroalkyl group represented by the formula (a) CH2?C(—X)—C(?O)—Y—Z—Rf, a first hydrophilic monomer represented by formula (b) CH2?CX11C(?O)—O—RO—X12, a second hydrophilic monomer represented by formula (c) CH2?CX21C(?O)—O—(RO)n—X22 or CH2?CX31C(?O)—O—(RO)n—C(?O)CX32?CH2, and (d) repeating units derived from a monomer having an anion donor and an ethylenic unsaturated double bond. Provided is a treatment composition which can impart outstanding water repellency, oil repellency and anti-fouling properties to a masonry substrate.Type: ApplicationFiled: July 31, 2019Publication date: November 21, 2019Applicant: DAIKIN INDUSTRIES, LTDInventors: Kanako TAKAHASHI, Masaki FUKUMORI, Ikuo YAMAMOTO
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Publication number: 20190352238Abstract: Systems and methods for collecting and processing livestock waste to facilitate the reclamation of water used in such processes and likewise produce fertilizer/soil amendments. Animal waste is initially collected, mixed with water and sequentially processed whereby large fibers present in the waste are separated, and the resultant manure sludge effluent. The manure sludge effluent may be treated with ultrasound, enzymatic pretreatment, aeration and/or polymers to promote coagulation and flocculation. A solids separation step is then performed to facilitate the separation of water and isolation of solids, the latter of which are formed into manure cakes and ultimately fertilizer/soil amendment products. The separated water is purified for reuse while further generating a nutrient concentrate.Type: ApplicationFiled: May 16, 2018Publication date: November 21, 2019Applicant: FIGURE 8, INC.Inventors: SCOTT HARRISON, SCOTT SEVERSON, ANDY ITURRIRIA
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Publication number: 20190352239Abstract: A process and system for preparing C2 to C5 hydrocarbons includes introducing a feed stream containing hydrogen gas and a carbon-containing gas selected from carbon monoxide, carbon dioxide, and mixtures thereof into a first reaction zone, contacting the feed stream and a hybrid catalyst in the first reaction zone, introducing a reaction zone product stream into a water removal zone that is downstream from the first reaction zone, and introducing a product stream from the water removal zone into a second reaction zone, resulting in a final stream comprising C2 to C5 hydrocarbons. The hybrid catalyst includes a methanol synthesis component and a microporous solid acid component; the microporous solid acid component is a molecular sieve having 8-MR access. The water removal zone removes at least a portion of water from the reaction zone product stream.Type: ApplicationFiled: November 15, 2017Publication date: November 21, 2019Applicant: DOW GLOBAL TECHNOLOGIES LLCInventors: Davy L.S. Nieskens, Aysegul Ciftci Sandikci, Peter E. Groenendijk, Barry B. Fish, Andrzej M. Malek
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Publication number: 20190352240Abstract: The present invention relates to a method for dehydrogenating an alkane, the method including: a step of feeding into dehydrogenation reactors a feed gas stream containing a hydrocarbon to be dehydrogenated, hydrogen, and steam and performing dehydrogenation, wherein the dehydrogenation step is repeated in five or more sets, the dehydrogenation reactors have two parallel-connected reaction material heaters configured to heat the feed gas stream which is fed into each of the dehydrogenation reactors, and the steam is fed separately to the individual reactors for five or more sets of dehydrogenation steps; and a step of cooling and compressing a production gas stream resulting from the previous step, quenching the compressed product gas stream by passage through a cooling box, separating and purifying the product gas stream having passed through the cooling box, and recovering a product.Type: ApplicationFiled: June 29, 2017Publication date: November 21, 2019Inventors: Bu Young JO, Won Il KIM
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Publication number: 20190352241Abstract: Disclosed is a process for producing highly pure chlorinated alkane in which a chlorinated alkene is contacted with chlorine in a reaction zone to produce a reaction mixture containing the chlorinated alkane and the chlorinated alkene, and extracting a portion of the reaction mixture from the reaction zone, wherein the molar ratio of chlorinated alkane:chlorinated alkene in the reaction mixture extracted from the reaction zone does not exceed 95:5.Type: ApplicationFiled: September 19, 2017Publication date: November 21, 2019Applicant: SPOLEK PRO CHEMICKOU A HUTNI VYROBU A.S.Inventors: Zdenek ONDRUS, Pavel KUBICEK, Karel FILAS, Petr SLADEK
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Publication number: 20190352242Abstract: The present disclosure provides separation processes for removing heavy organics that are formed in various production processes of HCFO-1233zd(E). Such separation processes allow for the recovery and/or separation of the heavy organics from reactants that are used to form HCFO-1233zd(E), including HF. Such separation or recovery processes may utilize various separation techniques (e.g., decanting, liquid-liquid separation, distillation, and flash distillation) and may also utilize the unique properties of azeotropic or azeotrope-like compositions. Recovery of the heavy organic that is substantially free from HF may allow for their use in subsequent manufacture processes or disposal.Type: ApplicationFiled: August 1, 2019Publication date: November 21, 2019Inventors: Yuon Chiu, Stephen A. Cottrell, Gustavo Cerri, Jennifer W. McClaine, Tao Wang, Rajiv Ratna Singh, Rajiv Banavali
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Publication number: 20190352243Abstract: Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.Type: ApplicationFiled: March 21, 2019Publication date: November 21, 2019Applicant: Massachusetts Institute of TechnologyInventors: Mircea Dinca, Constanze Nicole Neumann
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Publication number: 20190352244Abstract: The present invention aims to improve the production capacity of alcohol in a method of producing high concentration alcohol using a distillation column and an adsorption-desorption column. The method is a method of producing high concentration alcohol by dehydration of a water-alcohol mixture, including: a distillation step of introducing a water-alcohol mixture into a distillation column to obtain crude alcohol; and an adsorption-desorption step of introducing a part of the crude alcohol into an adsorption-desorption column to obtain high concentration alcohol; wherein a further part of the crude alcohol is introduced into a dehydration apparatus to obtain high concentration alcohol.Type: ApplicationFiled: July 29, 2019Publication date: November 21, 2019Applicant: Mitsubishi Chemical CorporationInventors: Tadafumi Yamamura, Hideto Hidaka, Hiroyuki Kakiuchi
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Publication number: 20190352245Abstract: A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.Type: ApplicationFiled: July 15, 2019Publication date: November 21, 2019Inventors: Michael J. Mona, III, Joshua A. Hartsel, Greg Waterbury
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Publication number: 20190352246Abstract: A halogenated ca-fluoroether of the formula (2) (where HaloR represents haloalkyl; R1 represents hydrogen, halogen, alkyl or substituted alkyl; and R2 represents alkyl or substituted alkyl) is produced efficiently on an industrial scale by reacting a halogenated aldehyde of the formula (1) (where HaloR represents haloalkyl) or an equivalent thereof with hydrogen fluoride.Type: ApplicationFiled: December 15, 2017Publication date: November 21, 2019Inventors: Kenji HOSOI, Naoya UESHIMA
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Publication number: 20190352247Abstract: Improved two phase chemical reactions (liquid-liquid or liquid-gas) are provided by forming microdroplets of either or both liquid reagents and configuring the reaction as a collision between the microdroplet reagent and the other reagent. We have found that this approach can provide high reaction yields in short times (<1 s) without the use of a phase transfer catalyst.Type: ApplicationFiled: February 8, 2018Publication date: November 21, 2019Inventors: Richard N. Zare, Xin Yan
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Publication number: 20190352248Abstract: The present disclosure relates to a method for upgrading lignocellulosic material carbohydrates and/or carbohydrate derivatives by dimerisation and/or oligomerisation using specific catalysts and to the use of the upgraded products.Type: ApplicationFiled: December 22, 2017Publication date: November 21, 2019Applicant: Neste OyjInventors: Marina LINBLAD, Mats KÄLDSTRÖM, Susanna WALLENIUS, Sören SUNDBLOM, Maaria SELÄNTAUS, Elias IKONEN
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Publication number: 20190352249Abstract: The invention provides novel deoxybenzoin-containing polymers exhibiting branched (including hyperbranched) architectures, and related methods and uses thereof.Type: ApplicationFiled: May 17, 2019Publication date: November 21, 2019Inventors: Moira Caitlin Brown, Elizabeth Ganz Stubbs, Todd Emrick
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Publication number: 20190352250Abstract: Processes for producing a disubstituted oxalate are disclosed. The process includes contacting a cesium salt with one or more alcohols and carbon dioxide (CO2) under reaction conditions sufficient to produce a composition comprising a disubstituted oxalate.Type: ApplicationFiled: January 26, 2018Publication date: November 21, 2019Inventors: Ahmad AL-JABER, Ilia KOROBKOV, Khalid ALBAHILY, Balamurugan VIDJAYACOUMAR
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Publication number: 20190352251Abstract: The present invention describes storage-stable glycerol (meth)acrylate carboxylic esters and a method for preparing these esters.Type: ApplicationFiled: November 14, 2017Publication date: November 21, 2019Applicant: Evonik Röhm GmbHInventors: Patrik HARTMANN, Marita KAUFMANN, Steffen KRILL, Thorben SCHÜTZ, Marcel TRESKOW, Andrea WITTKOWSKI
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Publication number: 20190352252Abstract: Synthetic methods for the preparation of ligands and metal-ligand complexes are disclosed.Type: ApplicationFiled: January 5, 2018Publication date: November 21, 2019Applicant: Univation Technologies, LLCInventors: Catherine A. Faler, C. Jeff Harlan
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Publication number: 20190352253Abstract: Disclosed are compounds having the following formula: (I) wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of ?2; or R is a quaternary amine having the following formula: (1a) wherein Ra and Rb are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of ?3.Type: ApplicationFiled: January 10, 2018Publication date: November 21, 2019Inventors: Gaik Babikyan, Benjamin Jiaravanon
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Publication number: 20190352254Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: ApplicationFiled: April 12, 2019Publication date: November 21, 2019Inventors: Alexander James Grenning, Sarah Scott
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Publication number: 20190352255Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.Type: ApplicationFiled: November 20, 2017Publication date: November 21, 2019Inventors: Barbara Slusher, Rana Rais, Jan Vavra, Tomas Tichy, Pavel Majer, Andrej Jancarik, Lukas Tenora
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Publication number: 20190352256Abstract: The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).Type: ApplicationFiled: December 22, 2017Publication date: November 21, 2019Applicant: Intervet Inc.Inventors: Michael Berger, Thorsten Meyer, Joachim Ullrich, Ralf Warrass
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Publication number: 20190352257Abstract: The present invention provides novel sotalol derivatives and pharmaceutical compositions containing the same that are are useful as pharmaceutical agents in the treatment of supraventricular and ventricular arrhythmias.Type: ApplicationFiled: April 30, 2019Publication date: November 21, 2019Inventors: John Somberg, Robert J Chorvat
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Publication number: 20190352258Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described.Type: ApplicationFiled: July 12, 2019Publication date: November 21, 2019Applicant: NanoSynthons LLCInventors: Donald A. Tomalia, David M. Hedstrand, Linda S. Nixon
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Publication number: 20190352259Abstract: Compositions comprising a lactam. Pharmaceutical compositions comprising such lactams for use in methods of treatment.Type: ApplicationFiled: October 19, 2017Publication date: November 21, 2019Inventors: Panagiotis KOTSAKIS, Neil James PARRY
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Publication number: 20190352260Abstract: Provided is a compound represented by Formula (1).Type: ApplicationFiled: July 29, 2019Publication date: November 21, 2019Applicants: NIKON CORPORATION, Kanagawa UniversityInventors: Yusuke KAWAKAMI, Kazuo YAMAGUCHI, Michiko ITOU
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Publication number: 20190352261Abstract: There is described a ROR? modulator of the formula (I), or stereoisomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof. Also provided are pharmaceutical compositions comprising the same. The compound of the invention may be useful in methods for modulating ROR? activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR? activity, for example, autoimmune and/or inflammatory disorders.Type: ApplicationFiled: May 16, 2019Publication date: November 21, 2019Inventors: T.G. Murali Dhar, Zili Xiao, Michael G. Yang
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Publication number: 20190352262Abstract: The present invention is directed to novel pleuroniutilin antibiotic compounds, intermediates which are useful for making these novel amibioiic compounds and related methods and pharmaceutical compositions for treating pathogens, especially bacterial infections, including gram negative bacteria and synthesizing these compounds.Type: ApplicationFiled: February 1, 2018Publication date: November 21, 2019Inventors: Seth Herzon, Stephen K. Murphy, Mingshuo Zeng
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Publication number: 20190352263Abstract: Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease. For example, compounds of Formula I, compositions containing the compounds, and methods for using the compounds and compositions are provided herein: wherein X is absent, CH2, or C(O); R1 is H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino; R2 is H or C1-6 alkyl; R3 is H, C1-6 alkyl, —C(O)(C1-3 alkyl), or —C(O)O(C1-3 alkyl); R4 is C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups; and R5 is OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino.Type: ApplicationFiled: June 6, 2019Publication date: November 21, 2019Applicant: Mayo Foundation for Medical Education and ResearchInventors: Eugenia Trushina, Robert Greenhouse, Kevin Greenman, William Thomas
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Publication number: 20190352264Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.Type: ApplicationFiled: July 15, 2019Publication date: November 21, 2019Applicant: Purdue Research FoundationInventors: Mohamed Seleem, Mingji Dai, Dexter Cameron Davis, Haroon Taj Mohammad
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Publication number: 20190352265Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.Type: ApplicationFiled: July 15, 2019Publication date: November 21, 2019Applicant: Purdue Research FoundationInventors: Mohamed Seleem, Mingji Dai, Dexter Cameron Davis, Haroon Taj Mohammad
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Publication number: 20190352266Abstract: The present invention relates to compounds of general formula I, wherein the groups R, R1, R2, R3, m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.Type: ApplicationFiled: January 22, 2018Publication date: November 21, 2019Inventors: Matthias ECKHARDT, Holger WAGNER, Stefan PETERS
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Publication number: 20190352267Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.Type: ApplicationFiled: July 2, 2019Publication date: November 21, 2019Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, JR.