Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: Ocular fundus inspection apparatus (10) having a frame (11) provided with references for the positioning of at least one of the patient's eyes in an inspection position, and an inspection unit (100) fixed to the frame (11) and comprising: a first optical unit (12) having an optical axis incident in correspondence of the inspection position references; an image detecting device (13); a second optical unit (14), for the focusing, having an optical axis incident on the detecting device (13), in said inspection unit (100) being defined an optical path between the first optical unit (12) and the detecting device (13); a first lighting unit (15) for projecting a focusing pattern, for focusing the ocular fundus on said detecting device (13), the focusing pattern being formed by an infrared radiation. The first lighting unit (15) emits the focusing pattern from a first emission position.

Abstract: Methods and apparatus, including computer program products, are provided for remote monitoring. In some example implementations, there is provided a method. The method may include receiving, at a remote monitor, a notification message representative of an event detected, by a server, from analyte sensor data obtained from a receiver monitoring an analyte state of a host; presenting, at the remote monitor, the notification message to activate the remote monitor, wherein the remote monitor is configured by the server to receive the notification message to augment the receiver monitoring of the analyte state of the host; accessing, by the remote monitor, the server, in response to the presenting of the notification message; and receiving, in response to the accessing, information including at least the analyte sensor data. Related systems, methods, and articles of manufacture are also disclosed.

Abstract: A system and method for applying a uniform dynamic gain over cardiac data with the aid of a digital computer is provided. A time series of a plurality of voltage values that comprises a digital representation of a raw electrocardiography (“ECG”) signal recorded by an ambulatory monitor recorder is obtained by an least one computer processor, the time series including segments of noise and segments of non-noise. The segments of non-noise are analyzed by the at least one computer processor and a single gain factor for all of the values in the analyzed non-noise segments is determined by the at least one computer processor based on the analysis. The single gain factor to all of the values in the non-noise segments is applied by the at least one computer processor.

Abstract: In part, the disclosure relates to systems for imaging a blood vessel using intravascular image data and extravascular image data and methods to calibrate such systems. In one embodiment, multiple calibration trials are performed to determine a plurality of time lag values. A minimum time lag value is used to align intravascular image data and extravascular time lag data in one embodiment.

Abstract: Apparatus and methods are described for receiving into at least one processor a set of images of blood vessels of a subject. A road map of the subject's blood vessels is generated, by automatically (a) deriving at least one image from the set of images of the blood vessels, based upon visibility of at least a portion of the blood vessels in the set of images, and (b) in the derived image, determining a location of edge lines of at least some of the portion of the blood vessels in the image. An output is generated by the processor, based on the road map. Other embodiments are also described.

Abstract: Provided is an object information acquiring apparatus including a supporting unit configured to be capable of holding a liquid acoustic matching member, a plurality of receiving elements each supported on the supporting unit to receive an acoustic wave propagated from an object via the acoustic matching member and output an electrical signal, a scanning unit that changes a relative position of each of the receiving elements and the object by moving the supporting unit, a controlling unit that controls a velocity of movement of the supporting unit performed by the scanning unit, and a processing unit that acquires specific information of an inside of the object based on the electrical signal. The scanning unit moves the supporting unit on a path having portions of different curvatures.

Abstract: An apparatus and method that utilizes thermal dilution to detect a wide range of flow rates and/or flow status in cerebrospinal fluid (CSF) shunt systems. The use of a large cold source in combination with thermosensor pad of a particular construction provide a fluid flow analyzer with the ability to detect very low levels of CSF flow. In addition, a method for adjusting thermal dilution readings to compensate for varying shunt catheter depth is shown and for determining a steady state of the thermal dilution readings. The thermosensor pad is conformable to a patient's skin contour thereby making the apparatus and method less sensitive to ambient temperature errors and, as a result, more accurate in assessing CSF flow. Furthermore, a software error check is provided for identifying poor sensor-to-skin contact for alerting an operator to re-apply the thermosensor pad to correct, as well as a post-test check to determine if temperature data is reasonable before determining flow status or flow rate.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example method may include a method for calculating fractional flow reserve including providing a pressure sensing guidewire, advancing the pressure sensing guidewire through a blood vessel to a first position distal of an intravascular occlusion, determining a distal pressure within the body lumen with the pressure sensing guidewire, proximally shifting the pressure sensing guidewire to a second position proximal of the occlusion, determining a proximal pressure within the body lumen with the pressure sensing guidewire, measuring an aortic pressure, and calculating a pressure drift. The pressure drift may be the difference between the aortic pressure and the proximal pressure. The method may also include calculating a drift-compensated fractional flow reserve. The drift-compensated fraction flow reserve may correspond to (the distal pressure+the pressure drift) divided by the aortic pressure.

Abstract: A method for monitoring autoregulation includes, using a processor, using a processor to execute one or more routines on a memory. The one or more routines include receiving one or more physiological signals from a patient, determining a correlation-based measure indicative of the patient's autoregulation based on the one or more physiological signals, and generating an autoregulation profile of the patient based on autoregulation index values of the correlation-based measure. The autoregulation profile includes the autoregulation index values sorted into bins corresponding to different blood pressure ranges. The one or more routines also include designating a blood pressure range encompassing one or more of the bins as a blood pressure safe zone indicative of intact regulation and providing a signal to a display to display the autoregulation profile and a first indicator of the blood pressure safe zone.

Abstract: Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a system for measuring blood pressure. The system may include a pressure sensing guidewire including a pressure sensor and a first optical fiber extending proximally from the pressure sensor. The system may also include an optical connector cable including a distal connector capable of being coupled to the guidewire. The optical connector cable may include a second optical fiber that is capable of optically communicating with the first optical fiber. A coupler may be disposed within the distal connector and disposed between the first optical fiber and the second optical fiber.

Abstract: Techniques, systems and apparatus are described for implementing a heart rate sensor based on optical measurements of color response of human blood. An optical heart rate sensor can include light source circuitry including a first light emitting diode (LED) to output a first source light signal to a target measurement site, a second LED to output a second source light signal to the target measurement site, a first current pulse driver communicatively coupled to the first LED to modulate the first source light signal output from the first LED at a first predetermined frequency and a second current pulse driver communicatively coupled to the second LED to modulate the second source light signal output from the second LED at a second predetermined frequency different from the first predetermined frequency. The optical heart rate sensor can include detector circuitry including a light detecting photodiode connected to a bias voltage.

Abstract: Small implantable silicon-based devices offer an ability to revolutionize the management of trauma victims. For example, implantable pressure sensors allow the devastating outcomes of compartment syndrome to be minimized through continuous or periodic monitoring whilst being compatible with the ongoing drives to increase out-patient care and reduced hospitalization time. Further, small implantable silicon-based sensor microsystems according to embodiments of the invention whilst being capable of measuring pressures under diverse conditions are easily used by nurses in hospital settings as well as also being easily deployed by paramedical personnel in cases of accidents, natural disasters, war, etc. Beneficially, the implantable sensor microsystem will not interfere with movement of the patient during stabilization, surgery, intensive care stay, outpatient management, etc.

Abstract: Disclosed is a method and system for selection of Electroencephalography (EEG) channels valid for determining cognitive load of subject. According to one embodiment, EEG signals are obtained from EEG channels associated with subject performing cognitive tasks are received. Time-frequency features of EEG signals are extracted for a frequency band comprise maximum energy value, minimum energy value, average energy value, maximum frequency value, minimum frequency value, and average frequency value. Weight of an EEG channel associated with time-frequency feature is derived using statistical learning technique. Binary values for EEG channels corresponding to time-frequency feature are assigned using weight of EEG channel associated with time-frequency feature.

Abstract: A portable medical device having improved ECG trace display and reporting. Embodiments implement features to ameliorate artifacts created by virtue of attempting to eliminate compression artifacts due to mechanical compression devices. Other embodiments additionally implement features to seek to detect the occurrence of ROSC while chest compressions are ongoing.

Abstract: An ECG monitoring system for ambulatory patients includes a disposable multi-electrode patch that adhesively attaches to the chest of a patient. A reusable battery-powered ECG monitor clips onto the patch and receives patient electrical signals from the electrodes of the patch. A processor continuously processes received ECG signals and stores the signals in memory in the monitor. The processor also analyzes the received ECG signals for predefined arrhythmia. If an arrhythmia is detected, a bi-directional wireless transceiver in the ECG monitor transmits the event information and an ECG strip to a cellphone handset. The cellphone handset automatically relays the event information and ECG strip to a monitoring center for further diagnosis and necessary intervention.

Abstract: A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display.

Abstract: A method and system are provided for measuring the cognitive state of an individual by combining analysis of 2 independent quantities derived from a single sensor. The method comprises placing an array of electrocardiogram (ECG) sensors in contact with the individual. The sensors continually measure the ECG voltages and signal-to-noise ratios from each ECG. A distance to sensor and pressure applied to sensor our calculated for each ECG sensor that corresponds to the ECG voltage and signal-to-noise ratio measurements from each respective ECG sensor. Next, a graphical distance and pressure map is generated based on the combined signal-to-noise ratios of the ECG sensors and continually analyzed to determine the cognitive state of the individual.

Abstract: The present invention provides systems and methods for monitoring a heart. According to one embodiment, the system includes an implantable registering unit for registering an electrical signal from the heart. The system includes a local data unit in operable communication with registering unit. The local data unit may be placed in communication with a computer, which may be at a location remote from the local data unit. The computer is adapted to receive the data from the local data unit corresponding to the registered electrical signal and to compare the registered electrical signal to a reference electrical signal to determine whether the heart is functioning properly.

Abstract: A system and method for profiling electrical activity in smooth muscle of the gastrointestinal tract muscular of a patient are disclosed. The system includes electromyographic-sensing patches adapted for placement on the skin of the abdomen of the patient. Each patch has at least one bipolar electrode pair, or a multitude arranged in an array, and is enabled for communication of a signal indicative of a sensed electromyographic signal. The system further includes networked computing devices. The local patch device is configured for wireless communication between the EMG-sensing patches and a local computing device, to enable wireless transmission from the patch to the networked computing devices. The networked computing device is configured to process large aggregate collections of multi-hour or day signals received from the local computing device to yield diagnostically valuable physiological parameters of gastrointestinal smooth muscle electrical activity.

Abstract: A magnetic resonance system, useful for imaging a patient, comprising: (a) a magnetic resonance device (MRD) for imaging a patient, comprising an open bore, the MRD at least partially contained in an envelope comprising in its circumference at least one recess; and, (b) an MRI-safe cart made of MRI-safe material, comprising a substantially horizontal base and at least one substantially horizontal incubator above the base, the base and the incubator are interconnected by at least one pillar. At least a portion of the cart and the MRD are configured to fit together such that at least a portion of the incubator is reversibly housed within the MRD, and further at least a portion of the base is reversibly housed within at least one recess.

Abstract: Systems and methods for monitoring medical procedures. Particular embodiments relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors.

Abstract: Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

Abstract: A wearable device and a method for monitoring eating are provided. The wearable device is wearable on an arm of a user and includes: an acceleration sensor, used to acquire acceleration information of the arm of the user; a processing unit connected to the acceleration sensor, used to calculate times of eating performed by the user in a predetermined duration based on the acceleration information and obtain an eating frequency of the user; a comparing unit connected to the processing unit, used to compare the eating frequency with a reference frequency and generate a first alarming signal if determining through comparison that the eating frequency is equal to or larger than the reference frequency; and an alarm connected to the comparing unit, used to alarm upon reception of the first alarming signal.

Abstract: A patient movement notification device is provided that includes a sensor pad for sensing movement of a patient and generating a signal when movement of the patient is sensed, and an electronics module for generating a notification of patient movement in response to receipt of the signal from the sensor pad. The patient movement notification device may be disposable. Accordingly, the electronics module may permanently shut down to become non-functional a specified time period after activation. Further, the electronics module may include a housing including a slot; a contact terminal disposed in the housing; a battery disposed in the housing; and a tab extending between the battery and the contact terminal and extending out through the slot, wherein the tab prevents the electronics module from receiving power until such time as a user pulls the tab from the slot. The housing may be sealed to prevent access to the battery.

Abstract: Methods and systems are provided for determining fluid responsiveness in the presence of noise. The system may determine an instantaneous value indicative of fluid responsiveness. In some embodiments, the system may determine a difference between an instantaneous value indicative of fluid responsiveness and a previous value indicative of fluid responsiveness, and select an update characteristic based on whether the difference indicates that the fluid responsiveness is increasing or decreasing. In some embodiments, the system may determine a parameter indicative of fluid responsiveness based on the update characteristic and a previously reported value indicative of fluid responsiveness.

Abstract: An oxygen saturation measuring sensor is capable of increasing reliability of information of parts having different depth and includes a pad attachable to a human body; plural light sources arranged on the pad to be adjacent in a separate state, and irradiate near-infrared light; plural light receiving elements arranged on the pad to be adjacent in a separate state and correspond one to one to the plural light sources with reference to a common center with an innermost side of the plural light sources, and that receive transmitted light from the corresponding plural light sources; and a ROM unit that stores a reference value through measuring transmitted light using a phantom in advance and stores a light receiving amount of the transmitted light received by the plural light receiving elements.

Abstract: A system for wirelessly monitoring the health of an infant comprising a sensing module removably disposed within a wearable article. At least a portion of the sensing module can be in contact with an infant's foot. The sensing module can include a processing unit configured to receive and process health readings received by the sensing module. A wireless transmitter can also be in communication with the processing unit. The wireless transmitter can be configured to transmit the processed health readings to a receiving station. The receiving station can indicate an alarm if the processed health readings indicate a health trend that falls outside of a particular threshold.

Abstract: A system, device and methods for quantitatively monitoring and evaluating changes in water and hemoglobin content in the brain in a non-invasive manner are provided. The system may be used for real-time detection and monitoring of brain edema and/or for an assessment of cerebral autoregulation.

Abstract: Methods and devices are provided for optically interrogating subsurface tissues of a body. Optical interrogation includes illumination of a target tissue through an external body surface and detection of light emitted in response to the illumination. Parameters of such optical interrogation are controlled according to operational modes that are selected to maximize detector sensitivity to a target property of the target subsurface tissues. Operational modes are selected based on detected properties of the target tissue and of intervening tissues (e.g., thickness of intervening tissues between the target tissue and an external body surface) between the target tissue and an interrogating optical device. Operational modes can be determined based on simulated optical interrogation of subsurface tissue across a range of optical detector configurations and tissue conditions. Operational modes can include calibration curves specifying optical interrogation parameters based on intervening tissue properties.

Abstract: A container assembly is disclosed including an outer container, a hollow inner member, and a closure. The outer container has a closed bottom, an open top, and a sidewall extending therebetween. The hollow inner member is disposed within the outer container and has an inner surface defining at least one capillary channel. The inner member includes a first end adjacent to the open top of the outer container and has an outer periphery seated against the sidewall of the outer container. The closure has a proximal end and a distal end. The closure proximal end is seated at least partially within the first end of the inner member to seal the outer container and inner member and define a fluid collection chamber. The closure distal end defines a recessed area shaped to direct fluid under capillary action to the at least one capillary channel in the inner member.

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract: Systems and methods for clinical assessment of balance may include a tilting balance platform further including: an upper platform, a lower platform, and an array of force transducers sandwiched between the upper platform and the lower platform. The systems may also include: a toroidal bladder supporting the lower platform; an air pressure sensor and a control valve connected to the toroidal bladder; an inclinometer that measures tilt information of the balance platform; and a computer that receives a control signal to activate one of: the array of force transducers and the inclinometer. If the array of force transducers is activated, then a clinical test is performed to measure changes to a subject's Center of Pressure on a stabilized balance platform, and if the inclinometer is activated, then another clinical test is performed to measure the tilt information caused by a subject's movements on a de-stabilized balance platform.

Abstract: The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. Preferably, the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity yielding a seizure index directly related to the current presence of ictal activity in the signal. Additionally, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. These indexes can be used in the context of emergency and/or clinical situations to assess the status and well-being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.

Abstract: A system for monitoring health parameters of a user includes a housing including: a plurality of sensors disposed on an outer surface of the housing or within the housing for measuring a plurality of parameters of interest; a processor disposed in the housing and communicatively coupled to the plurality of sensors; a coupling element on the housing for coupling the housing to an accessory; and an accessory identifier positioned on or within the housing and communicatively coupled to the processor. In some embodiments, the housing is reversibly transitionable between an uncoupled state and a coupled state with the accessory. In the coupled state, the accessory identifier senses a type of accessory and the processor activates a subset of the plurality of sensors to measure a subset of the plurality of parameters of interest. In some embodiments, the user is a pregnant female and a fetus developing in the pregnant female.

Abstract: A method for analyzing an image of a lesion on the skin of a subject including (a) identifying the lesion in the image by differentiating the lesion from the skin; (b) segmenting the image; and (c) selecting a feature of the image and comparing the selected feature to a library of predetermined parameters of the feature. The feature of the lesion belongs to any one selected from the group: color, border, asymmetry and texture of the image.

Abstract: This invention mainly discloses an EOG-based sleep staging method which is used to improve of an accuracy of automatic sleep judging result. The method may be executed by a processor and comprises steps of reading a to-be-test data having a variation depending on time of EOG generated by a user during a sleep process; acquiring a plurality of eye movement characteristics based on a variation of the EOG of a period, with the characteristics including an eye movement ratio, a blink count, a low frequency power ratio, a high frequency power ratio, an alpha rhythm ratio, a spindle rhythm ratio, a delta rhythm ratio and an average amplitude of eletrooculogram (EOG) signals; and determining a sleep state of the period is a “WAKE stage”, a “REM stage”, a “S1 stage”, a “S2 stage”, or a “SWS stage” based on the EOG characteristics. Furthermore, a computer readable medium with stored programs, and electronic apparatuses are provided.

Abstract: Surgical devices and methods for utilizing optical coherence tomography (OCT) to monitor and control tissue sealing are disclosed. The surgical device includes an end effector assembly that includes first and second jaw members that are movable between a first, spaced-apart position and a second proximate position. An OCT system, at least a portion of which is incorporated into the end effector assembly, is configured to sense properties of the tissue, e.g., the structural density of the tissue, disposed between the first and second jaw members. A tissue-sealing energy source may be disposed within at least one of the jaw members and may provide tissue-sealing energy to tissue disposed between the jaw members. A controller, which is coupled to the OCT system and the tissue-sealing energy source, controls the tissue-sealing energy generated by the tissue-sealing energy source based on the properties of the tissue sensed by the OCT system.

Abstract: A patient treatment unit for analyzing and treating abnormality of human or animal tissues, includes a display; a pulse generator circuit that outputs a sequence of electrical pulses at a pulse frequency, the electrical pulses having a pulse width, the pulse generator controlling the pulse frequency and the pulse width of the electrical pulses; a pair of probes for contacting a body of a patient and electrically coupled to the pulse generator; and a voltage and current sensing circuit that senses a voltage or a current via the probes when contacting the body of the patient.

Abstract: Methods and apparatuses for athletic training optimization are disclosed. In one example, a fitness level change is identified. In one example, a current training intensity is updated to reflect an updated user fitness level.

Abstract: In some embodiments, the instant invention provides for a computer-implemented method, including: providing, to a user, in real time, by at least one specialized computing device being specifically programmed with wellbeing management software, at least one personalized breathing instruction via a graphical user interface displayed on the at least one specialized computing device, receiving, in real time, by the at least one specialized programmed computing device, user sensor data from at least one heart rate sensor being associated with the user, determining, in real time, by the at least one specialized programmed computing device, user heart rate variability of the user (user HRV), based, at least in part, on the user sensor data, automatically calculating, by the at least one specialized programmed computing device, a parameter status percentage; providing, to the user, at least one personalized breathing recommendation being configured to modify the parameter status percentage.

Abstract: A system for control of a prosthetic device includes at least one Inertial Measurement Unit detecting orientation of a user's foot. The at least one Inertial Measurement Unit is in communication with a device module configured to command at least one actuator of a prosthetic device. The at least one Inertial Measurement unit sends output signals related to orientation of the user's foot to the device module and the device module controls the at least one actuator of the prosthetic device based on the signals from the at least one Inertial Measurement Unit.

Abstract: A dental appliance is described herein. The dental appliance includes an abutment device adapted to be coupled to a jawbone and a sensor support assembly coupled to the abutment device. The sensor support assembly includes a sensor chamber that is configured to receive a sensing device therein. A chamber cover is coupled to the sensor support assembly to enclose the sensor chamber. The chamber cover includes a plurality of orifices that are configured to couple the sensor chamber in flow communication with an oral cavity. A tooth cap is coupled to the abutment device and includes a cap opening to receive the sensor support assembly therein.

Abstract: A method involves supporting both a sensor which measures biological information and an insertion needle at a location proximally spaced from the distal end portion of a device body. The sensor includes a detector which detects a body fluid component of the patient used to measure the biological information, and a signal processor which is attached to the device body and which processes a signal including the biological information. The method also involves moving the sensor and the insertion needle in the distal direction so that the detector and a portion of the insertion needle protrude distally beyond the distal end portion of the device body, separating the insertion needle from the sensor by moving the insertion needle relative to the sensor toward a proximal direction, and electrically connecting the sensor and the signal processor by operation of the device body after the insertion needle is separated from the sensor.

Abstract: Aspects presented herein are directed to techniques for eliminating acquisition related artifacts in electro-physiological recording. In order to eliminate artifacts in neural response recordings, a pair of recordings is made with, respectively, inverted and non-inverted polarity at one pair of electrodes. An average of the two recordings will eliminate the acquisition artifact without the need for an extra recording, such as a baseline.

Abstract: Assemblies are provided for positioning within a lumen comprising a stent graft; and a sensor positioned on the stent graft. Within certain aspects the sensors are wireless sensors, and include for example one or more fluid pressure sensors, contact sensors, position sensors, pulse pressure sensors, blood volume sensors, blood flow sensors, chemistry sensors (e.g., for blood and/or other fluids), metabolic sensors (e.g., for blood and/or other fluids), mechanical stress sensors and/or temperature sensors.

Abstract: A computer-implemented method for biological signal recording, including modulating a sampled evoked biological signal with a carrier sequence code resulting in a modulated evoked biological signal. The carrier sequence code has an autocorrelation function. The method includes demodulating the modulated evoked biological signal by calculating a convolution of the modulated evoked biological signal with the carrier sequence code resulting in an evoked biological signal spectrum. The evoked biological signal spectrum has a peak to sideband ratio as a function of the carrier sequence code. The method includes calculating deviations between each element of the sampled evoked biological signal and the peak to sideband ratio and filtering noise artifacts from the sampled evoked biological signal based on the deviations. Peak to sideband ratios may also be optimized by varying the sampling rate.

Abstract: Methods and systems for medical diagnosis by machine learning are disclosed. Imaging data obtained from different medical techniques can be used as a training set for a machine learning method, to allow diagnosis of medical conditions in a faster a more efficient manner. A three-dimensional convolutional neural network can be employed to interpret volumetric data available from multiple scans of a patient. The imaging data can be analyzed in real-time to prescribe additional testing while the patient is still within the medical facility.

Abstract: Systems and methods for detecting events indicative of worsening using heart sounds are disclosed. A system can include a signal sensor circuit to sense a heart sound (HS) signal. The system can detect at least first and different second HS components using the HS signal, and generate respective first and second HS metrics. The system can determine a trend indicator for the first or second HS metric, and selectively generate one or more composite HS metrics using the first and second HS metrics, according to the trend indicator indicating a growing or decay trend. The system can include a heart failure (HF) event detector to produce a HF status using the composite HS metrics, and output an indication of the HF status, or deliver therapy according to the HF status.