Patents Issued in December 26, 2019
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Publication number: 20190388656Abstract: A system to dilate a stenotic region of an airway of a patient includes a stylet and a dilation catheter. The dilation catheter includes a catheter shaft and an inflatable balloon. The catheter shaft defines a shaft lumen and is configured to receive at least a portion of the stylet. The shaft lumen is axially aligned with a first longitudinal axis. The inflatable balloon is in fluid communication with an inflation lumen. The inflatable balloon is configured to transition between non-expanded and expanded configurations using the inflation lumen. The inflatable balloon has an outer perimeter configured to contact the stenotic region of the airway when in the expanded configuration. The inflatable balloon includes a pass-through lumen that is axially aligned with a second longitudinal axis that is laterally offset a distance from the first longitudinal axis. The pass-through lumen is disposed completely within the outer perimeter of the inflatable balloon.Type: ApplicationFiled: May 3, 2019Publication date: December 26, 2019Inventors: Ehsan Shameli, Fatemeh Akbarian
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Publication number: 20190388657Abstract: A catheter device and method are disclosed for transvascular delivery of a medical device to a cardiac valve region of a patient. The catheter device comprises an elongate sheath with a lumen and a distal end for positioning at a target site e.g. a heart valve.Type: ApplicationFiled: December 5, 2017Publication date: December 26, 2019Applicant: ITSO Medical ABInventor: Anders Jönsson
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Publication number: 20190388658Abstract: A balloon catheter has an outer shaft which surrounds a shaft lumen. The outer shaft has a proximal outer shaft portion connected to a distal outer shaft portion. An inner shaft is in a distal portion of the shaft lumen. A guide wire lumen is in the inner shaft. An opening at a proximal end portion of the inner shaft permits the guide wire to be guided out from the outer shaft. A metallic tube is in the shaft lumen. The proximal end portion of the inner shaft is engaged with the metallic tube. A separate, elongate and metallic stiffening element is in the shaft lumen, and is connected to the metallic tube and protrudes from the metallic tube into the distal portion of the shaft lumen and into the proximal portion of the shaft lumen to stiffen portions of the outer shaft.Type: ApplicationFiled: June 7, 2019Publication date: December 26, 2019Inventor: Bodo Quint
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Publication number: 20190388659Abstract: A urinary catheter device having a means for unblocking the catheter includes a tube, which has a distal end that is closed. The tube is resilient and is configured to insert through a urethra of an animal to position the distal end in a bladder. A hole is positioned through a wall of the tube proximate to the distal end and is configured to drain urine from the bladder through a proximal end of the tube, which is open. A channel extends through the wall from a first valve that is coupled to the tube to a chamber that is positioned in the wall proximate to the hole. Introduction of a fluid via the first valve into the chamber expands the chamber and increases a circumference of the hole so that debris that is impeding a flow of the urine through the tube enters and passes through the tube.Type: ApplicationFiled: June 21, 2018Publication date: December 26, 2019Inventor: Steven Ruel
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Publication number: 20190388660Abstract: A device and associated method for adjusting the opening pressure of an implantable valve. The valve has a rotor of rotation axis, whose angular position determines the opening pressure. The rotor has a rotor micro-magnet movable between positions of locking and unlocking, in which positions the micro-magnet respectively prohibits and permits the rotation of the rotor. The method includes: arranging a locator to align an axis of a locator receptacle with the rotation axis and to orient the locator in an angular position; determining the angular position of the rotor about its rotation axis with respect to the locator; inserting an actuator into the locator receptacle as far as a first insertion depth; partially withdrawing the actuator from the locator receptacle as far as a second insertion depth less than the first insertion depth; rotating the actuator starting from the second insertion depth; separating the actuator from the valve.Type: ApplicationFiled: February 1, 2018Publication date: December 26, 2019Inventor: Philippe NEGRE
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Publication number: 20190388661Abstract: A guidewire includes a guidewire shaft and an inflatable element arranged at a distal end of the guidewire shaft. At least a portion of the guidewire shaft is formed of metal, and the guidewire shaft includes a lumen that fluidly communicates with an interior of the inflatable element. The inflatable element is operable to transition between a deflated state in which the inflatable element is configured to pass through an isthmus of a Eustachian tube (ET), and an inflated state in which the inflatable element is configured to dilate the ET.Type: ApplicationFiled: June 22, 2018Publication date: December 26, 2019Inventors: Jetmir Palushi, Fatemeh Akbarian, Itzhak Fang, Athanasios Papadakis
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Publication number: 20190388662Abstract: A dilation catheter includes a shaft, a distal tip sized and configured to pass through an isthmus of a Eustachian tube (ET), and an expandable element moveable along an exterior of the shaft between a proximal position and a distal position. The expandable element is operable to transition between an unexpanded state in which the expandable element is configured for insertion into the ET via the isthmus, and an expanded state in which the expandable element is configured to dilate the ET.Type: ApplicationFiled: May 3, 2019Publication date: December 26, 2019Inventors: Jetmir Palushi, Fatemeh Akbarian
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Publication number: 20190388663Abstract: An intrathecal drug delivery system configured to monitor one or more physiological conditions of the patient to look for opportunities to time medicament delivery to coincide with patient activity inferring heightened cerebrospinal fluid oscillations, thereby improving dispersion of the medicament within the intrathecal space of the patient. The intrathecal drug delivery system includes an implantable medical pump, one or more physiological sensors, and an external programmer configured to program the implantable medical pump with a treatment protocol specifying at least one period of time during which a specified quantity of medicament is to be administered during which the implantable medical pump utilizes data from the one or more physiological sensors to time delivery of the medicament.Type: ApplicationFiled: June 18, 2019Publication date: December 26, 2019Inventor: Jeffrey Bodner
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Publication number: 20190388664Abstract: Provided is a method of controlling local release of target compounds by patterning a hydrogel carrying a bone morphogenetic protein as the target compounds on a nanoporous membrane. The nanoporous membrane is capable of controlling local release of the bone morphogenetic protein as a carrier of the bone morphogenetic protein while performing a basic function of the membrane of preventing infiltration of connective tissue, and thus, there is an advantage in that the nanoporous membrane can facilitate generation of controlled bone in a local region.Type: ApplicationFiled: June 26, 2019Publication date: December 26, 2019Inventor: Kwang Ho LEE
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Publication number: 20190388665Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.Type: ApplicationFiled: September 4, 2019Publication date: December 26, 2019Applicant: Boston Scientific Scimed, Inc.Inventors: Laura CHRISTAKIS, Ashleigh PETERSON, Jeffrey Bean, Claude CLERC, Andrew PIC, Gerald FREDRICKSON, Stan GILBERT, Amanda SMITH, Jose VEGA
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Publication number: 20190388666Abstract: Device for the medical treatment of humans and/or animals, particularly for treating wounds and/or dermatoses, comprising a reactive gas generator designed for generating reactive gases and an application device for applying the reactive gases in a treatment area, comprising a neutralization device designed for neutralizing reactive gases, by means of which the concentration of reactive gases outside the treatment area can be reduced.Type: ApplicationFiled: October 26, 2017Publication date: December 26, 2019Inventors: PATRICIA BUCHEGGER, DOMINIK BURGER, DARIUSZ KORZEC, STEFAN NETTESHEIM, CHRISTIAN ROHRER, FLORIAN HOPPENTHALER, KATHARINA MERZ
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Publication number: 20190388667Abstract: A closed-loop wearable device or platform integrates sensors, actuators, and microcontroller on board. The device is applied directly to the skin using stretchable epidermal electronics. It can sense a variety of signals from the human body, thus collecting medically relevant information, and can activate delivery of a therapeutic upon detection of an abnormal condition. The therapeutic can be delivered at a personalized dosage and/or with a unique combination of drugs or other agents based on the individual's metabolism as tracked by various sensor modules integrated with the medical device.Type: ApplicationFiled: April 14, 2017Publication date: December 26, 2019Inventor: Sheng Xu
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Publication number: 20190388668Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.Type: ApplicationFiled: December 15, 2017Publication date: December 26, 2019Inventors: Takuya TAJIMA, Naoki YAMAMOTO, Seiji TOKUMOTO
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Publication number: 20190388669Abstract: A microneedle comprising a shaft has a proximal end and a distal end and, optionally, a capillary space within said shaft, said capillary space (i) connecting said proximal and distal ends or (ii) extending from the distal end of the shaft and connecting with one or more external openings positioned between the proximal end and distal end or (iii) performing the functions of both (i) and (ii). The microneedle includes a polymer mixture that includes (a) polycarbonate, (b) polycarbonate-polysiloxane copolymer and (c) mold release agent.Type: ApplicationFiled: January 29, 2018Publication date: December 26, 2019Inventors: Maria Dolores MARTINEZ CANOVAS, Mark Adrianus Johannes VAN DER MEE, Robert Dirk VAN DE GRAMPEL, Johannes DE BROUWER, Herwig JUSTER
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Publication number: 20190388670Abstract: A method of forming a microneedle array having alternating layers of material includes transforming a multilayer sheet by cutting, assembling and stretching steps to form a stretched, stacked multilayer sheet. The stretched, stacked multilayer sheet is cut, assembled and stretched to form a film, the film is heated, and at least a portion of the film is caused to be displaced into a plurality of recesses thereby forming a plurality of protrusions at a surface of the film.Type: ApplicationFiled: January 30, 2018Publication date: December 26, 2019Inventors: Johannes DE BROUWER, Herwig JUSTER, Pieter Jan Antoon JANSSEN, Marco NEFS
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Publication number: 20190388671Abstract: A syringe having an enteral collar with a vent is disclosed. The syringe may also include a plug which reversibly covers the vent. Other embodiments relate to the use of the syringe. The vent allows fluid within the region between the enteral collar and the tip to be removed.Type: ApplicationFiled: June 21, 2018Publication date: December 26, 2019Inventors: Milind Rao, Lokesh Ramamurthy, Thirumurugan Nagu, Thomas Fraites
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Publication number: 20190388672Abstract: A dry-booster adapter assists in connecting a dry booster to an endoscope and may further assist in preventing detachment of the dry booster from the endoscope during a sterilization process. The adapter may include a fixation feature that fits between a surface of an endoscope control body and flanges thereof. It may also include another fixation feature including a locking tab. The adapter may also include a living hinge, which may assist in attaching the adapter to the endoscope, and that may be broken assist in removing the adapter from the endoscope.Type: ApplicationFiled: June 20, 2019Publication date: December 26, 2019Inventors: Cole Gavin MCNEAL, Samuel J. RHODES
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Publication number: 20190388673Abstract: A medical device including a connector portion having a distal end and a proximal end, and a screw groove configured for fluid communication between the connector portion and another medical device. The screw groove has a first side wall provided close to the distal end and a second side wall provided close to the proximal end. The first side wall has a stop portion whose lead angle has been reduced or eliminated.Type: ApplicationFiled: September 4, 2019Publication date: December 26, 2019Applicant: TERUMO KABUSHIKI KAISHAInventor: Toshihiko KAKINOKI
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Publication number: 20190388674Abstract: A medical connector that allows ventilation of vapor used in vapor sterilization and has an internal flow route that is tightly closable without using any separate clamping device.Type: ApplicationFiled: September 5, 2019Publication date: December 26, 2019Inventors: Shigeru Sasahara, Kazuhide Ono, Ryo Kato, Hironobu Sugiyama
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Publication number: 20190388675Abstract: Systems and methods are described for operating an electroporation system with single cell resolution. A micromanipulator assembly includes three orthogonally-positioned linear movement stages and a rotational stage to adjust the position of a tip of a micropipette. The system is configured to detect when the tip of the micropipette is placed in contact with an exterior surface of a cell based at least in part on a measured resistance from a first electrode positioned within the micropipette. In some implementations, the resistance is measured between the first electrode and a second electrode positioned at a defined distance from the tip of the micropipette and moved by the micromanipulator assembly with the micropipette. In some implementations, the control unit applies filtering and conditioning mechanisms to the measured resistance signal in order to detect contact between the tip of the pipette and the exterior surface of the cell.Type: ApplicationFiled: February 2, 2018Publication date: December 26, 2019Inventors: John Kohoutek, Jonathon Prinz
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Publication number: 20190388676Abstract: Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with local computing device and a remote server for patient monitoring, prescription and/or device servicing.Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Inventor: John Y. BABICO
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Publication number: 20190388677Abstract: A device for promoting healing of an injury in a living being is provided. Such device is based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.Type: ApplicationFiled: September 9, 2019Publication date: December 26, 2019Inventors: Lisa S. Carnell, Emilie J. Siochi, Kam W. Leong
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Publication number: 20190388678Abstract: Various methods of manufacture can produce three-dimensional, high density, high-electrode probe arrays that can advantageously be used in neural-based applications. In one example, deep reactive ion etched (DRIE) ultra-high aspect ratio holes are etched in silicon and refilled with multiple films to a high density array of individual probes, each probe having individual recording and/or stimulation sites or tips. Using a DRIE lag effect technique can help control tip sharpness and electrode length, allowing for narrow, long, and dense needles to be formed side-by-side in a single array. In some examples, multimodal probe arrays are manufactured, with some probes having a recording/stimulating site, other probes having a waveguide, and yet other probes having a microfluidic channel.Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Inventors: Khalil Najafi, Seyed Amin Sandoughsaz Zardini, Daniel Egert
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Publication number: 20190388679Abstract: A method of analyzing performance of a brain stimulation tool is disclosed. The method comprises: obtaining encephalography data collected from a brain of a subject electrically stimulated by at least one of the electrode contacts of the brain stimulation tool; segmenting the data into a plurality of epochs, each corresponding to a single stimulation event generated by the brain stimulation tool; and applying a spatiotemporal analysis to the epochs so as to determine at least one of (i) location of the at least one electrode contact in the brain, and (ii) therapeutic effect of the at least one electrode contact.Type: ApplicationFiled: March 7, 2018Publication date: December 26, 2019Applicants: Elminda Ltd., Yissum Research Development Company of the Hebrew University of Jersusalem Ltd.Inventors: Amir B. GEVA, Hagai BERGMAN, Ziv PEREMEN, Dror HAOR, Daniel SAND, Yaki STERN, Boaz SADEH
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Publication number: 20190388680Abstract: A shield member is placed within a polymer flexible carrier in between a manipulation member used to aid implant of a nerve cuff and the nerve to avoid touching the nerve surface with the manipulation member because the texture or material of the flexible member typically causes more foreign body reaction or other biologic reaction from the nerve and surrounding tissues than the polymer of the flexible carrier itself.Type: ApplicationFiled: June 26, 2018Publication date: December 26, 2019Inventor: Ravi JAIN
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Publication number: 20190388681Abstract: An information processing device that determines a treatment content to be performed from a behavior tendency of a user itself of an electrical treatment device. The information processing device includes a control unit configured to control the information processing device, wherein the control unit includes a storage processing unit configured to acquire behavior information indicating a content of a behavior of a user of an electrical treatment device and store the behavior information in a storage unit, a tendency determination unit configured to determine a behavior tendency on the basis of the behavior information indicating the content of the behavior of the user stored in the storage unit, and a program determination unit configured to determine a treatment program for causing the electrical treatment device to perform a treatment content corresponding to the behavior tendency.Type: ApplicationFiled: September 6, 2019Publication date: December 26, 2019Applicant: OMRON HEALTHCARE Co., Ltd.Inventors: Mitsuru SAMEJIMA, Yui WATANABE, Makoto TABATA, Tetsuya SATO, Shozo TAKAMATSU
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Publication number: 20190388682Abstract: Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.Type: ApplicationFiled: August 27, 2019Publication date: December 26, 2019Inventors: Mir A. Imran, Mir Hashim, Emily Arnsdorf
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Publication number: 20190388683Abstract: A system and method are provided for a wireless electrical stimulation. The system generally includes at least two electrical stimulation units. Each electrical stimulation unit includes electrodes connected to the unit. The system also includes a transmitter for remotely, wirelessly controlling each of the electrical stimulation units to selectively apply a time-varying electric potential to the electrodes to provide an electrical stimulation to tissue in electrical contact with the electrodes.Type: ApplicationFiled: September 5, 2019Publication date: December 26, 2019Inventor: Eric Ye CHEN
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Publication number: 20190388684Abstract: A stimulation device includes an energy source; an electronics unit; an actuator that is coupled with the electronics unit and/or the energy source. The electronics unit includes a controller. The energy source, the electronics unit and the actuator are arranged in a housing. A fixing unit which is coupled with the housing and affixes the stimulation device on a heart or in a heart. The actuator emits electromagnetic waves for the stimulation of genetically manipulated tissue, and the controller controls the stimulation of the tissue by way of the electromagnetic waves of the actuator.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388685Abstract: An implantable device for implantation in a human body or animal body. The device includes an energy source, an energy storage device, and an electronics unit. Further, an actuator is coupled with the energy storage device and it is configured to emit electromagnetic waves by discharging the energy storage device.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388686Abstract: A stimulation device contains an energy source, an electronics unit, and an actuator that is coupled with the electronics and/or the energy source. The actuator is configured to emit electromagnetic waves for stimulation of genetically manipulated tissue. The stimulation device is configured for at least temporary implantation in the human or animal body. The electronics unit has a controller configured to stimulate the tissue by use of the electromagnetic waves from the actuator.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388687Abstract: A device has an energy source, an electronics unit and a pickup unit that is coupled with the electronics unit and is configured to measure electromagnetic waves in the frequency range 1013-1020 Hz. The device is configured for implantation in the human or animal body. The device is configured to detect that the electromagnetic waves were radiated from genetically manipulated tissue.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388688Abstract: Methods and apparatuses to detect configuration commands from waveforms received at a retina prosthesis device for calibrating the device are described. The device can comprise an array of pixel units to receive light to stimulate neuron cells to cause an effect of visual sensation from the light. The pixel units may have configurable parameters for the stimulation to the neuron cells. The configurable parameters may be updated according to the configuration commands detected without requiring micro processor and non-volatile memory in the device. The stimulation may be generated according to the updated configurable parameters to improve the effect of visual sensation from the light including compensation for the physiological and environmental variations and drifts.Type: ApplicationFiled: August 30, 2019Publication date: December 26, 2019Inventor: LONG-SHENG FAN
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Publication number: 20190388689Abstract: A device is described that is implantable in the human or animal body, this device comprising at least one substance that is designed to modify human or animal cell structures so that action potentials in the cell structures can be detected and/or evoked by irradiation with electromagnetic waves in the frequency range 1013-1020 Hz. The device comprises application means to deliver the substance to the tissue.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388690Abstract: A closed loop control system automatically ensures that an output of a device is constant. The system can receive an input to set a fixed value for a variable (e.g., a current, a heart rate, a tissue perfusion, an ion level, etc.), and this variable can be delivered to a feedback component. The system can also include the device to deliver the variable to a load. The feedback component can be coupled to the delivery device to sample the output of the delivery device at different times. Based on the sampling, the feedback component can vary a property of the delivery device related to the delivery of the variable to the load to ensure that the variable remains constant at the fixed value. In some instances, the system can be implemented as a stimulator that delivers the constant current of a current source and has a low output impedance of a voltage source.Type: ApplicationFiled: September 4, 2019Publication date: December 26, 2019Inventor: Dominique M. Durand
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Publication number: 20190388691Abstract: The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.Type: ApplicationFiled: June 4, 2019Publication date: December 26, 2019Inventors: Jesse J. Wheeler, Philip D. Parks, James E. Moran, Andrew Czarnecki, Keith B. Baldwin, David Goldberg, Alex Kindle, Marc W. McConley
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Publication number: 20190388692Abstract: Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of time and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Inventors: David A. Dinsmoor, Heather Diane Orser, Scott R. Stanslaski, Erik J. Peterson
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Publication number: 20190388693Abstract: Some embodiments relate to a method of adjusting therapeutic stimulation from a therapeutic stimulation system. The method comprising: providing therapeutic stimulation based on a plurality of stimulation parameters to a patient with an implanted controller and at least two electrodes; receiving data indicative of feedback associated with a patient rating of the therapeutic stimulation via a patient input device; automatically adjusting, with the implanted controller, at least one of the plurality of stimulation parameters; and providing adjusted therapeutic stimulation based on the adjusted at least one stimulation parameter to the patient with the controller and the at least two electrodes.Type: ApplicationFiled: January 30, 2017Publication date: December 26, 2019Inventor: Hugh McDermott
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Publication number: 20190388694Abstract: A deep brain stimulation system, said system comprising: a programmable neurostimulator, said neurotransmitter having a first output and a second output; a first electrical line, said first electrical line having a first color and functionally connected to said first outlet of said neurostimulator; a second electrical line, said second electrical line having a second color and functionally connected to said second outlet of said neurostimulator; a first deep brain stimulating lead, said first lead connected to said first electrical line; a second deep brain stimulating lead, said second lead connected to said second electrical line; said neurostimulator programmed to deliver a unique first signal through said first electrical line and a unique second signal through said second electrical line.Type: ApplicationFiled: June 24, 2018Publication date: December 26, 2019Inventor: Kara Stumpf
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Publication number: 20190388695Abstract: Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of time and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Inventors: David A. Dinsmoor, Kristin N. Hageman, Hank Bink
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Publication number: 20190388696Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.Type: ApplicationFiled: June 20, 2019Publication date: December 26, 2019Inventors: Ignacio A. Armesto, Luis Daniel Villamil, Refet Firat Yazicioglu, Kristina Schlegel, Kent Leyde
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Publication number: 20190388697Abstract: Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.Type: ApplicationFiled: July 2, 2019Publication date: December 26, 2019Inventors: GABY PELL, ABRAHAM ZANGEN, YIFTACH ROTH, ALON FRIEDMAN, UDI VAZANA
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Publication number: 20190388698Abstract: Methods for treating a patient using time varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.Type: ApplicationFiled: September 4, 2019Publication date: December 26, 2019Inventors: Tomás SCHWARZ, Ondra PROUZA
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Publication number: 20190388699Abstract: A stimulation device has an energy source, an electronics unit with a controller, a fixing unit and an actuator that is coupled with the electronics and/or the energy source. The actuator is configured to emit electromagnetic waves for stimulation of genetically manipulated tissue. The stimulation device is configured for at least temporary implantation in a human or animal body. The controller is configured to control the stimulation of the tissue by use of the electromagnetic waves of the actuator. The stimulation device has a control unit that picks up data that characterizes the tissue activity and/or the success of a stimulation by a stimulation carried out through the electromagnetic actuator.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388700Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: April 12, 2019Publication date: December 26, 2019Applicant: Circuit Therapeutics, Inc.Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
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Publication number: 20190388701Abstract: A stimulation system includes an energy source, an electronics unit with a controller, and an actuator that is coupled with the electronics unit and/or the energy source. The actuator emits electromagnetic waves for stimulation of genetically manipulated tissue. The electronics unit is disposed in a housing. The stimulation system is configured for at least temporary implantation in a human or animal body. The controller controls the stimulation of tissue in the body by way of the electromagnetic waves emitted by the actuator. A selector of the stimulation system selects the area of the said tissue for stimulation. The selector includes a masking device for masking certain areas of the tissue, so that an intensity of the stimulation for the masked areas is reduced or equal to zero.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: THOMAS DOERR, INGO WEISS
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Publication number: 20190388702Abstract: A tumor treatment method for treating a tumor in a subject, the method includes: a step I of administering a therapeutically effective amount of one or a plurality of antibody-IR 700 molecules to the subject, in which the antibody specifically binds to a cell surface protein of the tumor; a step II of inserting an optical probe into the subject; a step III of applying light having a wavelength in a range from 660 nm to 740 nm from the optical probe, to supply energy of at least 1 J/cm2 to at least a part of the tumor; a step IV of waiting for a time until an immune response is elicited in the tumor; a step V of inserting an energy device into the subject; and a step VI of resecting tissues of the subject including the tumor using the energy device.Type: ApplicationFiled: June 20, 2018Publication date: December 26, 2019Applicant: OLYMPUS CORPORATIONInventors: Toshiaki WATANABE, Masahiro YOSHINO, Tetsuhide TAKEYAMA, Motohiro MITAMURA
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Publication number: 20190388703Abstract: A system includes a laser source coupled to an optical waveguide which has a laser output portion, and a vaginal housing transparent to laser energy which is emitted by the laser source and which exits the laser output portion, wherein the optical waveguide is movable along a path inside the vaginal housing.Type: ApplicationFiled: June 26, 2018Publication date: December 26, 2019Applicant: Zlasers Ltd.Inventor: Ziv Karni
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Publication number: 20190388704Abstract: Differing from conventional approaches for improving sexual dysfunction of an adult man being commonly achieved by letting the adult man administer a dosage of synthetic drug or a composition of Chinese herbal medicines, the present invention particularly discloses a method for treating male sexual dysfunction by using underpants comprising far-infrared fibers. Clinical data have proved that, after wearing this underpants for 3 months, both the men diagnosed with sexual dysfunction and the men not sure to suffer from sexual dysfunction have an apparent progress on improvements of their erectile ability, erectile quality, ejaculation control ability, and lower urinary tract symptoms (LUTS). Moreover, clinical data have also proved that, despite the fact that a male person wears the underpants provided by the present invention for three months, there is no adverse effect induced by the underpants for causing the physiological condition of the men be abnormal.Type: ApplicationFiled: September 5, 2019Publication date: December 26, 2019Inventor: Tien-Show LIANG
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Publication number: 20190388705Abstract: Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing an NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Inventors: Karl Deisseroth, Feng Zhang, Edward Boyden