Abstract: A system and method is provided to measure intrathoracic complex impedance and to identify and indicate disease conditions based on the impedance measurements. Multiple impedance vectors may be taken into account, and an optimal vector may be selected to provide the most useful impedance measurement for the identification and indication of disease conditions.

Abstract: The present disclosure relates to various methods for determining a neuromuscular blockade status and systems suitable for performing such methods. The present disclosure further relates to electro-stimulation electrodes for stimulating a muscle of a patient, optionally in the context of at least some of the mentioned methods. The present disclosure still further relates to hybrid air-signal connectors for use in an electro-stimulation cuff which can be used in the context of at least some of the cited methods. The present disclosure also relates to electro-stimulation circuits comprising an electrode portion and a track portion suitable for pressure cuffs for electro-stimulation, and to pressure cuffs configured to be arranged around a limb of a patient and comprising an active electro-stimulation electrode and a passive electro-stimulation electrode. These electro-stimulation circuits and pressure cuffs may also be used in the context of at least some of the mentioned methods.

Abstract: Disclosed herein, among other things, are apparatus and methods for automated assessment and adjustment of tinnitus-masker impact on speech intelligibility during use of the tinnitus-masker. In various embodiments, a method of fitting a tinnitus-masker device for a patient is provided. The method includes using a speech intelligibility model to predict impact of therapy provided by the tinnitus-maker device on speech understanding of the patient. A parameter of the tinnitus-masker device is automatically adjusted during use to reduce the impact of the therapy provided by the tinnitus-maker device on speech understanding of the patient, according to various embodiments.

Abstract: Apparatuses and methods for improving the accuracy of an analyte sensor are disclosed. The sensor may include a photodetector and a low angle sensitive (LAS) optical filter. The photodetector may be configured to convert received light into current indicative of the intensity of the received light. The LAS optical filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass region to the photodetector. The percentage of light passing through the LAS optical filter may decrease as the angle of incidence of the light increases.

Abstract: The subject matter discloses a device for measuring biological properties of an examined tissue, the device comprising at least one light source configured and operable to illuminate the examined tissue with light radiation of one or more wavelengths at a certain light illumination direction; and a light detector located at a same side of said examined tissue and configured and operable to receive light components of said one or more wavelengths reflected from the examined tissue in response to the illuminated light radiation at a certain light detection direction, and to generate measurement data indicative thereof; at least one of said light illumination direction and detection direction is positioned at an angle of at least 20 relative to an imaginary line perpendicular to the examined tissue or form an angle of at least 20 between the light illumination direction and detection direction.

Abstract: A device includes source and detector sensors. In a specific implementation, the device has two near detectors, two far detectors, and two sources. The two near detectors are arranged closer to the two sources than the two far detectors. A light-diffusing layer covers the two near detectors. The device may be part of a medical device that is used to monitor or measure oxygen saturation levels in a tissue. In a specific implementation, light is transmitted into the tissue and received by the detectors. An attenuation coefficient is first calculated for a shallow layer of tissue. The attenuation coefficient is then used to calculate an attenuation coefficient for a deep layer of tissue.

Abstract: A device for measuring electrophysiological data includes: a series of electrodes; a control circuit including a DC voltage source connected to the electrodes in order to apply, to a pair of electrodes, DC voltage pulses, and in order to connect another high-impedance electrode; and a measurement circuit for measuring the potential of the electrodes and data representative of the current passing through at least one active electrode. The device further includes at least one base incorporating the control circuit and the measurement circuit, and a housing suitable for receiving an electrode assembly which includes at least one electrode of the series in a removable manner, so as to be able to connect or disconnect the electrodes to/from the control circuit and to/from the measurement circuit.

Abstract: Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier and lubricity coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system is also disclosed.

Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.

Abstract: A system and a method is provided for assessing motion of a biological tissue of a subject including one or more superficial biological layers and a targeted biological layer. An optical perturbation is introduced within the one or more superficial biological layers but not within the targeted biological layer. A set of optical signal data is acquired preceding, during, or following the optical perturbation and, using the set of optical signal data, a set of optical characteristics is determined that is representative of light transiting the biological layers. Using the set of optical characteristics and a model of the biological layers, a target optical signal consistent with a target biological layer is separated and a movement of the desired biological tissue is determined using the target optical signal.

Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.

Abstract: The subject matter described herein relates to methods, systems, and computer readable media for visualization of a resection target during epilepsy surgery and for real time spatiotemporal visualization of neurophysiologic biomarkers. One exemplary method includes a real time neurophysiologic biomarker visualization system implemented by at least one computer, receiving, as input, a pre-electrode-implantation MRI of an epilepsy patient's brain.

Abstract: Apparatuses for detecting swallowing disorders and methods for using same are provided. In a general embodiment, the apparatuses include a disposable sensor base and a sensor that is received by the disposable sensor base. The sensor base includes a sensor interface having a predetermined cut-away shape and a directionally-keyed mating surface. The sensor includes a handle portion having a shape that corresponds to the predetermined shape of the sensor interface, a support portion configured to be received by the directionally-keyed mating surface when the sensor is inserted into the sensor interface, and electronics configured to collect data sensed by the sensor. The apparatuses of the present disclosure can be attached to a patient's neck to detect and/or diagnose swallowing disorders during a swallowing test.

Abstract: A method of operating a CPAP apparatus in which the interface pressure is controlled to rapidly drop at the start of expiration by an expiratory relief pressure (ERP) that is independent of instantaneous respiratory flow, following which the pressure rises to an inspiratory level at or shortly before the end of expiration, or at the onset of an expiratory pause, if any. The ERP is an increasing function of the inspiratory pressure. The expiratory pressure follows a template that is a function of the expected expiration time, the magnitude of the template being equal to the ERP. The current estimated proportion of expiration is determined by comparing the expiration time of the breath in progress to low-pass filtered expiratory durations measured for a number of the preceding breaths.

Abstract: The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.

Abstract: Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.

Abstract: According to the embodiments, a medical image diagnosis apparatus includes a memory and processing circuitry. The memory stores volume data on a target portion including a vessel network and a plurality of blood vessels connected to the vessel network. The processing circuitry extracts the vessel network and the blood vessels from the volume data. The processing circuitry analyzes how hemodynamics in the vessel network are after treatment of the vessels.

Abstract: The present invention includes two embodiments of a tethered ankle-foot prosthesis, one with a single toe to provide plantarflexion and with two independently-actuated toes that are coordinated to provide plantarflexion and inversion-eversion torques. An end-effector was designed which is worn by a subject, and which was integrated with existing off-board motor and control hardware, to facilitate high bandwidth torque control. The platform is suitable for haptic rendering of virtual devices in experiments with humans, which may reveal strategies for improving balance or allow controlled comparisons of conventional prosthesis features. A similar morphology is also effective for autonomous devices.

Abstract: The present disclosure relates generally to electronic devices and methods for sensor signal collection. The electronic devices may include retroreflectors for redirecting scattered light back to the photodetector. The retroreflectors may be positioned at various locations on or in the electronic device, and may employ various geometric elements having retroreflective capability.

Abstract: A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a diffuser. The diffuser is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the diffuser.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.

Abstract: A computer-implemented method including, transmitting a high-spectrum energy wave towards a subject from a first sensor and transmitting a low-spectrum energy wave towards the subject from a second sensor. In response, modulation with a carrier sequence code results in a modulated evoked biological signal. The carrier sequence code has an autocorrelation function. The method includes demodulating the modulated evoked biological signal by calculating a convolution of the modulated evoked biological signal with the carrier sequence code resulting in an evoked biological signal spectrum. The evoked biological signal spectrum has a peak to sideband ratio as a function of the carrier sequence code. The method includes calculating deviations between each element of the sampled evoked biological signal and the peak to sideband ratio and filtering noise artifacts from the sampled evoked biological signal based on the deviations.

Abstract: Systems and methods are provided for determining respiration information from physiological signals such as PPG signals. A physiological signal is processed to generate at least one respiration information signal and an autocorrelation sequence is generated based on the at least one respiration information signal. In some embodiments, a respiration peak is identified based on the autocorrelation sequence and a composite peak is generated based on the identified peak and at least one previous respiration peak. Respiration information is calculated based on the composite peak. In some embodiments, a determination is made whether the autocorrelation sequence includes an undesired harmonic. When the autocorrelation sequence includes an undesired harmonic, the autocorrelation sequence may not be used in the calculation of respiration information.

Abstract: A system to generate medical monitor alarm settings (10) which includes a normative analyzer (36) and/or observational analyzer (48) configured to receive (130) data from logs (32, 34) of a plurality of medical monitors (12), and generate (134, 138) one or more suggested alarm settings (26) based on a constructed model of the received log data.

Abstract: A system and method for monitoring a medical procedure performed in a clinical environment is provided. An audio recorder is configured to produce a verbal data signal that is representative of a verbal communication occurring in the clinical environment, and a data analyzer is configured to detect an adverse condition based upon the verbal data signal. An alert module is configured to alert an operator upon the detection of an adverse condition.

Abstract: Self-describing calibration targets for inclusion in medical imagery and automated quality control and calibration are provided. In various embodiments, a medical image is received. The medical image includes a calibration target in its field of view. A description of the calibration target is read from the calibration target. The description includes size and at least one color reference. Based on the description of the calibration target, correction parameters are determined for the medical image. The correction parameters include pixel shape correction parameters, scale correction parameters, contrast correction parameters, or color correction parameters.

Abstract: Techniques are provided that enable displaying of medical images that depict cyclic motions in the subject. An X-ray CT system scans, with X-rays, the subject whose targeted region is experiencing a cyclic motion and acquires detection data. This X-ray CT system comprises a reconstruction processor, a moving image creator, and a display controller. The reconstruction processor generates a plurality of sets of volumetric data based on a plurality of sets of detection data that have been acquired during one cycle of the cyclic motion. The moving-image creator creates a moving image that shows the cyclic motion, on the basis of at least a part of the plural sets of volumetric data. The display controller superposes the moving image over an image based on the volumetric data and displays these images on the display unit.

Abstract: An X-ray device for an inverse computer tomography configuration, includes a plurality of X-ray emitters and a detector arranged opposite the X-ray emitters. The X-rays emitted by the X-ray emitters can be detected by the detector after at least partly passing through an examination region located in the intermediate region between the X-ray emitters and the detector. In an embodiment, the X-ray emitters are grouped into at least two mutually spaced sub-arrangements. Each sub-arrangement comprises multiple X-ray emitters. The spacing between the at least two sub-arrangements is greater than the spacing between adjacent X-ray emitters of at least one of the sub-arrangements.

Abstract: A radiation imaging apparatus is provided. The apparatus comprises pixels arranged in an image sensing region, a first and a second detecting elements configured to obtain radiation irradiation information, a first signal line to which a signal from the first detecting element is to be output and a second signal line to which a signal from the second detecting element is to be output, and a signal processing circuit configured to process the signals output from the first and the second detecting elements. The first the second signal lines are arranged in the image sensing region or arranged adjacent to the image sensing region, the first detecting element has a larger region to detect radiation than the second detecting element. The signal processing circuit generates the radiation irradiation information based on the signals from the first and the second signal lines.

Abstract: According to one embodiment, a medical image diagnostic apparatus includes a gantry, columns, gantry drive motors, position detectors, and gantry control circuitry. The gantry has a bore along a vertical direction. The columns movably support the gantry along the vertical direction, with one end of the bore facing a floor surface and the gantry being interposed between the columns. The gantry drive motors move the gantry along the vertical direction. The position detectors detect support positions at which the gantry is supported in each of the columns. The gantry control circuitry determines whether or not movement of the gantry along the vertical direction is possible, based on information regarding misalignment between the support positions.

Abstract: A radiation tomography system is provided that includes a control unit to control a data collection system to acquire first data by scanning a first scan region centered on a first position in a body axis direction of a subject in synchronization with heartbeats, and second data by scanning a second scan region adjacent to the first scan region and centered on a second position in the body axis direction in synchronization with the heartbeats. A reconstructing unit is provided to reconstruct an image of a slice between the first position and second positions using the first and second data. The reconstructing unit determines a view-angle-range-based use rate for the first data and a view-angle-range-based use rate for the second data according to the position of the slice relative to the first and second positions.

Abstract: An extra-oral imaging apparatus is intended to obtain a cephalometric image of a portion of a head of a patient. Exemplary apparatus embodiments of cephalometric functionality of such extra-oral imaging apparatus can include a cephalometric support mounted to a base of the imaging system that is configured to position a cephalometric sensor about a cephalometric imaging area so that x-rays impinge the cephalometric sensor after radiating the cephalometric imaging area. A cephalometric patient positioning unit mounted to the cephalometric support can be positioned between an x-ray source of the x-rays and the cephalometric sensor. A cephalometric alignment sight can be mounted to patient positioning unit to provide a visual indication of alignment between the x-ray source and the mounted alignment sight/cephalometric sensors. Exemplary methods are provided that can use such exemplary cephalometric alignment sights and/or install cephalometric functionality to imaging systems using the same.

Abstract: Systems and methods for determining an attenuation sinogram for a time-of-flight (TOF) positron emission tomography (PET) scan using only TOF PET data, and including use of the total amount of tracer provided to the subject of the TOF PET scan, are provided. The total amount of injected tracer can be used to determine the otherwise unknown constant shift present when an attenuation sinogram is estimated using the gradient of the attenuation sinogram. The attenuation sinogram can therefore be accurately and stably determined without any additional knowledge on the attenuation sinogram or map.

Abstract: A three-dimensional, head mounted microphone array is employed to isolate and analyze intracranial sound sources such as may provide for objective tinnitus. The microphone array allows a region of interest within the patient's head to be isolated for the detection of sounds and allows episodic sounds to be automatically identified as to location. An interactive display allows a better understanding of sound locations and the extracted sounds can be analyzed with respect to a library of sounds linked to particular locations and diagnoses.

Abstract: An ultrasound diagnosis apparatus includes: transmission and reception circuitry that generates reception signals corresponding to channels, from reflected waves arranged to be received at mutually the same time by transducer elements that transmitted an ultrasound wave, by controlling transducer elements included in an ultrasound probe; extracting circuitry that extracts, prior to a beam forming process, first signals corresponding to the channels from the reception signals corresponding to the channels while suppressing signals originating from a tissue and further extracts a second signal by performing the beam forming process after suppressing, of the extracted first signals corresponding to the channels, a component in a predetermined direction; calculating circuitry that calculates blood flow information from the second signal; and controlling circuitry that generates a blood flow image from the blood flow information and causes display to display the generated blood flow image.

Abstract: Ultrasound devices and guidance systems for ultrasound devices for subdermal devices (e.g., needles) used in conjunction with the ultrasound devices are described. The guidance systems can includes features for easy release of a device from the system following targeting to a subdermal site. A guidance system can be ambidextrous such that a needle can be released by use of either the left or right hand and by use of either a thumb or a finger of an operator. Embodiments that include guidance tracks and slidable guidance cartridges that grasp the hub of a subdermal device are also described.

Abstract: A method and ultrasound imaging system for detecting a coherent reflector comprises acquiring ultrasound channel data from a volume with a probe including a 2D aperture, calculating a MRT from the ultrasound channel data, identifying a first angle of a projection of the coherent reflector in a plane parallel to the 2D aperture based on the MRT, detecting a line-shaped echo pattern in the ultrasound channel data, determining a second angle of the coherent reflector with respect to the 2D aperture, determining a position and an orientation of the coherent reflector based on the first angle and the second angle, enhancing a representation of the coherent reflector in an image generated based on the ultrasound channel data, and displaying the image on a display device after enhancing the representation of the coherent reflector.

Abstract: Embodiments of the invention provide a dermatological cosmetic treatment and imaging system and method. In some embodiments, the system (20) includes a hand wand (100) with at least one finger activated controller (150, 160), and a removable transducer module (200) having an ultrasound transducer (280). In some embodiments, the system (20) can include a control module (300) that is coupled to the hand wand (100) and has a graphical user interface (310) for controlling the removable transducer module (200), and an interface (130) coupling the hand wand (100) to the control module (300). The interface (130) may provide power to the hand wand or may transfer a signal from the hand wand to the control module. In some embodiments, the cosmetic treatment system (20) may be used in cosmetic procedures on at least a portion of a face, head, neck, and/or other part of a patient.

Abstract: Various embodiments include systems and methods for detecting amniotic fluid position based on shear wave propagation. Ultrasound image data may be acquired, and shear wave related data for an area corresponding to the acquired ultrasound image data may also be acquired. Identification data associated with one or more particular structures or elements within the area may be generated based on the shear wave related data, and ultrasound imaging during an ultrasound examination may then be controlled based on the identification data. The ultrasound imaging may comprise generating and rendering one or more ultrasound images based on the acquired ultrasound image. The ultrasound examination may be obstetric (OB) ultrasound examination, with the area comprising one or more of: at least portion of a fetus, amniotic fluid surrounding the fetus, and tissue of a mother carrying the fetus.

Abstract: Medical tool positioning and control devices, systems, and methods. Handle assemblies that allow a steerable shaft to be steered, while allowing the separate movement of a medical tool. The handle assemblies can allow for rotation and axial movement of the medical tool, and optionally with an actuator disposed distal to a second actuator that controls steering of the steerable shaft.

Abstract: An information providing method which is implementable by using an ultrasound apparatus includes obtaining ultrasound image data which relates to an object; displaying, on a first area of a screen, a gain setup window for setting a gain of the obtained ultrasound image data; receiving a gain which is set by a user on the gain setup window; and displaying, on a second area of the screen, an ultrasound image of the object to which the set gain is applied.

Abstract: A catheter for prevention of stroke by diverting and filtering the blood flow to carotid and vertebral arteries is provided. The catheter includes at least one balloon with an outer mesh cover that expands upon the balloon inflation and stays expanded after the balloon is deflated. The inflation of the balloon in the aortic arch or head vessels provides the deflection of embolic particles from the cerebral circulation and expands the outer mesh that provides for filtering and deflection of cerebral emboli after the balloon is deflated. An associated method of prevention of cerebral emboli and embolic stroke is provided.

Abstract: A method of generating an image of a scanned subject includes: emitting, by multiple ultrasonic elements of an array, multiple respective ultrasonic signals into a subject, the multiple respective ultrasonic signals defining at least two beam portions traveling in different directions; receiving, by the multiple ultrasonic elements, multiple respective ultrasonic echo signals; and generating at least one image of a portion of the subject from the received multiple ultrasonic echo signals. A negatively focused wavefront including the at least two beam portions traveling in the different directions may be emitted. Multiple negatively focused wavefronts may be generated and emitted.

Abstract: The present invention obtains certainty of the blood-flow velocity information that is estimated in the blood-flow mapping display. The signal processor in the ultrasound imager is provided with a Doppler velocity operation part configured to calculate a Doppler velocity from echo signals by using the Doppler effect, and a first blood-flow velocity operation part configured to generate a tissue tomographic image from the echo signals and calculate a blood-flow velocity of a predetermined portion from a motion of the tissue, on the basis of the tissue tomographic image. It is further provided with a second blood-flow velocity operation part configured to calculate the blood-flow velocity of the predetermined portion by using the Doppler velocity calculated by the Doppler velocity operation part.

Abstract: A biopsy device for percutaneous tissue removal includes an elongated housing having an operational axis, a stylet hub slidably mounted in the housing, where the stylet hub is movable relative to the housing between a proximal, armed position, and a distal, fired position, the stylet hub having a stylet strike, a cannula hub slidably mounted in the housing alongside the stylet hub, and a spring-biased arming member. The cannula hub is movable relative to the housing between a proximal, armed position, and a distal, fired position. The arming member is moveably mounted to the housing proximal of the respective stylet and cannula hubs, and configured for manually-actuated movement from a relaxed, extended position to a loaded, compressed position to define a compressive arming stroke. The biopsy device also includes an arming member biasing spring that restores the arming member from the compressed position to the extended position.

Abstract: An apparatus for closing an opening in a body tissue. The apparatus includes a shaft, a plurality of arms, and an expander. The arms each extend between a proximal end and a distal end. The distal end of each arm is hingedly attached to or integrally formed with the shaft. The arms are laterally spaced apart from each other. The arms are movable between a retracted configuration, in which the arms are each aligned along the shaft, and a deployed configuration, in which the proximal end of each arm pivots respectively about the distal end of the arm so as to extend laterally away from the shaft. The expander is positioned within the shaft, and movement of the expander causes the arms to move between the retracted and deployed configurations. Methods of using the apparatus are also included.

Abstract: A method for closing a puncture in a vessel wall of a blood vessel that includes advancing a guide member into proximity with a puncture in a vessel wall, positioning a distal end of an angle adjustment member distal to openings of the guide member, deploying the needle guides from the guide member through the openings, advancing the deflected needle guides and the suture securing devices through the vessel wall, retracting the needle guides to release the suture securing devices distally of the vessel wall, and establishing tension in the sutures to move the suture securing devices toward each other to thereby close the puncture.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.