Abstract: This document provides implantable intraluminal stent graft medical devices. In some embodiments, the stent graft devices provided herein are implantable in bodily conduits that have side branches, and the stent graft devices are operable to allow the flow of fluids between the conduit and the side branches. In some embodiments, the walls of the stent graft devices provided herein include compliant channels which allow for fluid communication between the interior and the exterior of the stent graft devices. In some embodiments, the compliant channels are configured to inhibit or reduce tissue ingrowth, tissue bridging, and/or endothelialization.

Abstract: The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In a first embodiment of the present invention, a two part prostheses, where one part is an expandable sponge structure and the other part is an expandable tubular mesh structure, is provided. In the first embodiment, the expandable sponge structure is intended to fill the aneurysm cavity to prevent further dilatation of the vessel wall by creating a buffer or barrier between the pressurized pulsating blood flow and the thinning vessel wall. In the first embodiment, the expandable tubular mesh structure is placed across the aneurysm, contacting the inner wall of healthy vessel proximal and distal to the aneurysm.

Abstract: The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In one embodiment, a system for treating an aneurysm is disclosed. The system comprises a catheter delivery system, an expandable foam configured to pass through the catheter delivery system, and a stent having a first end and a second end. The stent is configured to extend across the aneurysm. The expandable foam is configured to expand in the aneurysm when exposed to a fluid.

Abstract: A torsional actuator formed of a yarn of twisted shape memory material. The yarn has multiple strands of homogeneous shape memory material that have been homochirally twisted. For torsional actuation, a fractional portion of the yarn is heated such as by Joule heating. Various Joule heating mechanisms include passing an electrical current through an unwound segment of the yarn, or by coating a fractional portion of the length of each homogeneous strand with a coating material of higher electrical conductivity than the electrical conductivity of the shape memory material an passing current through the length of the yarn. The shape memory material may be a shape memory alloy such as a NiTi alloy.

Abstract: An implantable article for attaching tendons and/or ligaments to bone and/or cartilage, assemblies thereof, and methods of use thereof are provided. The article is configured for attaching at least one of a tendon and a ligament to at least one of bone and cartilage. The article comprises a membrane comprising a biological material that promotes cell growth. The membrane comprises a first end, a second end, a cavity, and an expandable portion. The second end is configured to be attached to at least one of the bone, the cartilage, the tendon, and the ligament. The cavity extends from the first end to the second end. The cavity is configured to receive the cell growth mixture from the open end. The expandable portion is positioned intermediate the first end and the second end and is configured to increase in size responsive to the cell growth mixture entering the cavity.

Abstract: Embodiments concern an intraocular implantable device operable comprising a disk-shaped body having a symmetry axis and which further comprises a light-transmissive portion and an opaque portion wherein the light-transmissive portion is decentered with respect to the symmetry axis.

Abstract: Apparatuses, systems and methods for providing improved intraocular lenses (IOLs), include features for reducing side effects, such as halos, glare and best focus shifts, in multifocal refractive lenses and extended depth of focus lenses. Exemplary ophthalmic lenses can include a continuous, power progressive aspheric surface based on two or more merged optical zones, the aspheric surface being defined by a single aspheric equation. Continuous power progressive intraocular lenses can mitigate optical side effects that typically result from abrupt optical steps. Aspheric power progressive and aspheric extended depth of focus lenses can be combined with diffractive lens profiles to further enhance visual performance while minimizing dysphotopsia effects. The combination can provide an increased depth of focus that is greater than an individual depth of focus of either the refractive profile or the diffractive profile.

Abstract: A method of forming an electrospun prosthetic valve includes utilizing a rotatable and angularly adjustable prosthetic valve mold. The prosthetic valve mold is set to a first angle. The prosthetic valve mold is rotated at a first rotational velocity and a first layer of electrospun fibers is deposited on the prosthetic valve mold. The prosthetic valve mold is stopped and a frame is positioned over the first layer. The prosthetic valve mold is set to a second angle. The prosthetic valve mold is rotated at a second velocity and a second layer of electrospun fibers is deposited on an outer surface of the first layer and an outer surface of the frame.

Abstract: A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from a polymeric composition. When the method is employed to replace a native mitral valve, the method positions the prosthetic valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.

Abstract: A prosthetic heart valve includes a self-expanding wire frame body, a valve disposed in the body, a leaflet clip coupled to the body, and a control element operably coupled to the leaflet clip. The body has a proximal end and a distal end. The leaflet clip is configured to be transitioned between a first configuration in which the prosthetic valve can be inserted into a heart, and a second configuration in which the leaflet clip is disposed to capture a native valve leaflet between the leaflet clip and the wire frame body when the body is disposed in a native annulus of an atrioventricular valve of a heart. The control element extends from the leaflet clip through a ventricle of the heart and out a wall of the ventricle to allow a user to transition the leaflet clip from its first configuration to its second configuration.

Abstract: A prosthetic heart valve includes a self-expanding wire frame body, a valve disposed in the body, a leaflet clip coupled to the body, and a control element operably coupled to the leaflet clip. The body has a proximal end and a distal end. The leaflet clip is configured to be transitioned between a first configuration in which the prosthetic valve can be inserted into a heart, and a second configuration in which the leaflet clip is disposed to capture a native valve leaflet between the leaflet clip and the wire frame body when the body is disposed in a native annulus of an atrioventricular valve of a heart. The control element extends from the leaflet clip through a ventricle of the heart and out a wall of the ventricle to allow a user to transition the leaflet clip from its first configuration to its second configuration.

Abstract: Features for a restraint, such as a cap, are described. The restraint secures a cardiac device in a collapsed, delivery configuration for transcatheter delivery to a heart. The restraint may have a tubular sidewall extending from a proximal end to a distal end, a proximal opening defined by the sidewall at the proximal end and a channel defined by the sidewall and extending distally from the proximal opening. The restraint is configured to receive the implant in the collapsed configuration through the proximal opening to radially restrain the implant within the channel. The restraint eliminates the need for a surrounding sheath, reducing the delivery profile and size of the overall delivery system, among other advantages. The restraint may have an atraumatic leading edge to reduce the risk of injury to the patient.

Abstract: The invention pertains to implants that facilitate tissue expansion while not substantially inhibiting normal anatomical movement. The implants may be made of different materials or made in different configurations such that such that a measured property at a first location on said implant is different than said same measured property at a second location on said implant. In one particular embodiment the implants may be a cosmetic penile implant.

Abstract: According to an aspect, an implant includes an inflatable member and a pump assembly configured to facilitate a transfer of a fluid from the reservoir to the inflatable member. The inflatable member defining a lumen and including a structural member. The inflatable member includes a coating.

Abstract: An implant is provided that is operable to be disposed between and fuse two sections of a bone. The implant includes an inner layer and an outer layer. The outer layer at least partially surrounds the inner layer and is operable to abut against the two sections of the bone. The outer layer is porous and/or fibrous and is operable to receive at least one cellular growth factor.

Abstract: Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.

Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.

Abstract: A bone fusing implant device includes an elongated body extending along a longitudinal direction. The elongated body includes a first segment having an outer surface with cortical threads, a second segment having an outer surface with cancellous threads, a top segment and a bottom segment. The first segment is adjacent to the second segment along the longitudinal direction and is configured to engage a cortical bone with the cortical threads and the second segment is configured to engage a cancellous bone with the cancellous threads. The elongated body has one or more elongated fusing gutters extending along the longitudinal direction on an outer surface of the elongated body covering the first and second segments, a central opening extending along the longitudinal direction through the elongated body's center and one or more through-openings that extend horizontally and intersect with the one or more fusing gutters.

Abstract: An intervertebral disc replacement device comprising a superior plate and an inferior plate, in which each plate contains one or more embedded magnets. The one or more magnets in the superior plate and the one or more magnet in the inferior plate are oriented such that a magnetic force exists between the one or more magnets in the superior plate and the one or more magnet in the inferior plate. In addition, an intervertebral disc replacement device comprising a superior plate and an inferior plate, in which each plate contains one or more embedded magnets, and the plates are designed to form an articulating surface. Further, an intervertebral disc replacement device comprising a superior plate, an inferior plate, and a spacer, in which each plate contains one or more embedded magnets, and the superior and inferior plates are designed to form articulating surfaces with the spacer.

Abstract: A multi-matrix composite socket includes struts formed from a first matrix composite and inner and outer layers relative to the struts formed from at least a second matrix composite. Each matrix composite is comprised of fibers embedded in a resin. The fibers create spaces into which a flowable resin infuses during manufacturing and also reinforce the resin. A base and a plurality of struts are assembled and positioned over a first fabric layer and a second fabric layer is positioned over the struts. A resin is infused into the spaces defined by the first and second fabric layers and around the struts to form an over-molded multi-composite matrix socket.

Abstract: The present invention is directed to an autonomous exoskeleton device that includes one or more actuators, one or more controllers, one or more sensors with one or more unidirectional transmissions. The present invention provides a mechanical joint in parallel with a biological joint. The exoskeleton device preferably includes and electric motor and winch, chain, belt, cam transmission or other mechanism for providing unidirectional force to assist rotation about the biologic joint. Moreover, a controller, a motor angle sensor, joint angle sensor and/or force sensor may be used for additional control and monitoring of the device. The motor may be any type of motor, but is preferably brushless in configuration where its diameter is larger than its length to provide a compact and lightweight exoskeleton device.

Abstract: The present invention is directed to an autonomous exoskeleton device that includes one or more actuators, one or more controllers, one or more sensors with one or more unidirectional transmissions. The present invention provides a mechanical joint in parallel with a biological joint. The exoskeleton device preferably includes and electric motor and winch, chain, belt, cam transmission or other mechanism for providing unidirectional force to assist rotation about the biologic joint. Moreover, a controller, a motor angle sensor, joint angle sensor and/or force sensor may be used for additional control and monitoring of the device. The motor may be any type of motor, but is preferably brushless in configuration where its diameter is larger than its length to provide a compact and lightweight exoskeleton device.

Abstract: A prosthetic joint can include a first attachment member and a second attachment member coupled to the first attachment member. The second attachment member can include a cylindrical chamber. The prosthetic joint can include a fixation system disposed within the cylindrical chamber comprising at least one cam. The prosthetic joint can have an unlocked configuration, wherein in the unlocked configuration the first attachment member and the second attachment member can rotate relative to each other. The prosthetic joint can have a locked configuration, wherein in the locked configuration the first attachment member is substantially prevented from rotating relative to the second attachment member.

Abstract: Artificial limbs and joints that behave like biological limbs and joints employ a synthetic actuator which consumes negligible power when exerting zero force, consumes negligible power when outputting force at constant length (isometric) and while performing dissipative, nonconservative work, is capable of independently engaging flexion and extension tendon-like, series springs, is capable of independently varying joint position and stiffness, and exploits series elasticity for mechanical power amplification.

Abstract: A system for powering a prosthetic arm is disclosed. The system includes at least one internal battery located in the prosthetic arm, at least one external battery connected to the prosthetic arm, and a master controller configured to connect either the at least one internal battery or the at least one external battery to a power bus to power the prosthetic arm.

Abstract: A continuous socket/suspension monitoring system according to principles of the present invention tracks relative displacement between amputee residuum and their socket using magnetic sensors. The system includes at least one magnetic sensor in a liner worn on the amputees' residuum which correspond to sensors provide in or on the prosthesis socket. The system allows for monitoring of pistoning continuously during locomotion and does not require socket modification, is safe to amputee patients, is easy to use, and is low cost.

Abstract: An adjustable prosthetic socket includes proximal and distal ends and an axis extending between the proximal and distal ends. A distal base is adapted to support a distal portion of a residual limb and is located at the distal end of the socket. First and second spines extend upward from the distal base that define at least part of a circumference of the socket about the axis. A proximal support is connected to the second spine and arranged to distribute pressure from the second spine over a portion of the residual limb. A tensioning system is operatively connected to the first and second spines and arranged to selectively adjust the circumference of the socket. The tensioning system includes a dial tensioner connected to the first spine.

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Abstract: The invention relates to a medical device and a method of using it. The device is a stent which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The stent is configured to have a central portion defined by “open” cells and at least two end portions, defined by “closed” cells, spaced apart and directly connected to the distal and proximal ends of the central portion of the stent. The stent may also optionally have a covering or a lattice with openings.

Abstract: A delivery catheter comprises an inner shaft and an outer sheath. A stent-graft is held on a region of the inner shaft. An enlarged diameter distal region of the outer sheath constrains the stent-graft. Its retraction allows the stent-graft to deploy. A finger wheel on a handle is used to retract the outer sheath and is coupled to a sliding block with cable(s). The sliding block is coupled to the outer sheath and is held within a sliding track. The wheel can be actuated to tension the cable(s) and deform latch(es) coupled to sliding block, freeing them from slot(s) in the sliding track and allowing retraction of the sliding block and the outer sheath. A reinforcement sleeve is coupled to a smaller diameter proximal region of the outer sheath. A gap between the outer sheath distal region and the reinforcement sleeve allows the distal outer shaft region to be retracted.

Abstract: There is described an endovascular prosthesis delivery device. The subject endovascular prosthesis delivery device comprises a combination of a delivery frame element and a hub insert element that are secured to one another by a first retention element. At a distal portion of the delivery frame element, there is a prosthesis attachment zone for coupling to an endovascular prosthesis. When it is desired to deploy the endovascular prosthesis, the first retention element is broken in a manner to allow relative movement between the hub insert element and the delivery frame element. A pull wire assembly is secured with respect to the hub insert element and comprises a pull wire which is coupled to the endovascular prosthesis in the prosthesis attachment zone of the delivery frame element.

Abstract: A system and method for non-surgical treatment of plantar fasciitis is disclosed. The system comprises a primary support strap split at both ends; a secondary support strap split at one end; and a cover support strap; wherein the straps are applied to a foot such that the combination of straps provides dynamic windlass support to the foot.

Abstract: An active wearable system includes a one or more positioning elements configured as a torso support and/or other wearable item, one or more sensors for sensing motion, posture, or gait of a subject, and at least one of force applying elements for applying force to selected regions of a body of a subject, and feedback device and other actuators, under the control of control circuitry responsive to sensed motion, posture or gait of the subject. In an aspect, force is applied according to spatial or temporal patterns. Related devices and methods are described.

Abstract: Devices for nasal insertion may include an open-ended tubular element which extends along a central tube axis between a first end and a second end, the first end being larger than the second end, and in which the tubular element includes at least one spiral strut extending from the first end to the second end, and/or a nodule having an internal face, a rounded external face, and a stalk extending from the internal face and terminating in an anchor sufficiently larger than a receptacle in the tubular element and sufficiently deformable as to be pressed through the receptacle to affix the nodule to the tubular element.

Abstract: A hygiene product is provided having a waterproof layer with a perimeter and an adhesive strip disposed around the perimeter of the waterproof layer. The adhesive strip has a body-facing side and an air-facing side, wherein the body-facing side has an adhesive material that is configured to adhere to a user's body and the air-facing side has an adhesive material that is configured to adhere to the perimeter of the waterproof layer. The hygiene product also includes a pull tab attached to the waterproof layer, wherein the pull tab is configured to detach at least a portion of the waterproof layer from the adhesive strip to define an opening through the adhesive strip and the waterproof layer is re-attachable to the adhesive strip after the at least a portion of the waterproof layer is detached from the adhesive strip.

Abstract: A container for menstrual collection and emptying thereof, in the shape of a cup or of a flat cup, with a drainage tube composed of at least one very flexible thin-walled portion, and a wall portion of greater thickness. By applying an upward force on the portion, the tube is folded by its portion closing off the liquid passageway, and the tube end remaining directly anchored to the vaginal wall or below a hollow formed in the container. For a mid-day emptying, a downward force is applied on the portion to unfold the drainage tube. The horizontal rim of the cup has a number of notches to aid the folding and can have a sloped shape, or double-ringed.

Abstract: Disclosed is a pessary for transvaginal haemostasis, wherein the radial dimension of a balloon body can be changed to form a relatively large pressure on a vaginal wall, therefore achieving the effect of high-pressure haemostasis.

Abstract: A method may include accessing a terminal branch of an ophthalmic artery through a face of a subject. Additionally, the method may include positioning a device within the ophthalmic artery of the subject and treating at least one of a blockage, a stenosis, a lesion, plaque or other physiology in at least one of the ophthalmic artery or a junction between an internal carotid artery and the ophthalmic artery.

Abstract: A method for determining spherical aberration parameters for a corneal laser treatment to treat presbyopia may include performing pupillometry to measure various actual pupil diameters of a patient from a photopic diameter to a mesopic diameter. An actual pupil center of the patient may also be measured. The measured pupil diameters and the pupil center may be used to customize the spherical aberration parameters to the eye of the patient for improved ocular results after treatment.

Abstract: In certain embodiments, apparatus for self-aligning elements of coupled platforms includes a radially repulsive magnetic bearing. The radially repulsive magnetic bearing includes a first axially polarized magnet and a second axially polarized magnet that is concentrically disposed around the first axially polarized magnet and radially repulsive to the first axially polarized magnet. The radially repulsive magnetic bearing is configured to align a first element of a first platform with a second element of a second platform when the first and second platforms are coupled together.

Abstract: An ophthalmic implant for drug delivery. The implant includes a primary intracapsular device coupled to a secondary device, wherein, when implanted in a patient's eye, the primary intracapsular device is held in place by the patient's capsular bag and the secondary device is held in place by the primary intracapsular device. The implant may be inserted in the eye by injecting the primary intracapsular device into the eye either before or after attaching the secondary device to the primary intracapsular device, and subsequently positioning the joined secondary device and primary intracapsular device with the primary intracapsular device held in place by the patient's capsular bag and the secondary device held in place by the primary intracapsular device. The secondary device may be designed to hold a tertiary device that can be implanted and attached at the time of surgery or anytime postoperatively.

Abstract: Devices, systems, and methods for performing an ophthalmic procedure in an eye are disclosed. The devices include a hand-held portion and a distal, elongate member coupled to the hand-held portion having a lumen operatively coupled to a vacuum source. A drive mechanism operatively coupled to the elongate member is configured to oscillate the elongate member. When in use, the device is configured to aspirate ocular material from the eye through the lumen. The drive mechanism retracts the elongate member with a retraction speed profile and advances the elongate member with an extension speed profile. The retraction speed profile is different from the extension speed profile.

Abstract: A tympanostomy tube containing a polymeric material and a drug is described. The polymeric material may comprise a non-resorbable polymer and a water-soluble polymer. The drug may be released when the device is contacted by an aqueous liquid such as middle ear exudate during otitis media. The implant may contain sufficient drug to treat multiple episodes of otitis media or to catch subsequent episodes in their early stages as a prophylactic. The device may be hydrophilic and further may contain a surfactant. The implant may be porous. The implant may have enhanced surface area at places exposed to middle ear liquid and may have enlarged mass so as to contain an increased total amount of drug. Intentional reorientation of the patient's head may aid in moving drug-containing liquid around the middle ear cavity. Similar implants can be used in other mucosal cavities.

Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.

Abstract: An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. microfiltration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.

Abstract: The tape product prevents wounds on skin when peeling off a tape member from occurring. The tape product 100 includes a tape member 10 having an adhesive surface, and a mesh member 20 releasably provided on the adhesive surface of the tape member 10. When the tape product 100 is applied to skin, the adhesive surface of the tape member 10 adheres to the skin through the openings 21 of the mesh member 20.

Abstract: Disclosed embodiments relate to apparatuses and methods for wound treatment. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, a spacer layer, an absorbent layer positioned on the spacer layer, an electronics unit comprising a negative pressure source and/or electronic components, wherein the absorbent layer comprises a recess configured to receive the electronics unit and the absorbent layer is configured to be in fluid communication with the electronics unit, and a cover layer configured to cover and form a seal over the wound contact layer, the spacer layer, the absorbent layer, and the electronics unit.

Abstract: A mouth-insertable device, including a main body having a cylindrical shape, a first end disposed at an end of the main body, and a second end disposed at another end of the main body opposite from the first end, wherein the main body has a size to fit between an inner upper lip and an upper gum line of a user.

Abstract: Absorbent articles of the present disclosure may be constructed with a secondary liner sheet placed on top of a body facing liner of the articles configured to form a pocket. The pocket provides a barrier, thereby separating a front region of the absorbent articles from a rear region. In this manner, the absorbent articles of the present disclosure may reduce the spread of bodily exudates throughout the articles. The reduced spreading of exudates may help to keep skin healthy by reducing the amount of skin exposed to the skin irritants within the exudates and/or by preventing additional skin irritants from being created by preventing the mixing of BM and urine, at least in proximity to the skin of the wearer.

Abstract: A disposable absorbent article, having a front-back direction that is perpendicular to a width direction and a thickness direction that extends from a skin contact surface side to a non-skin contact surface side of a wearer, includes: an absorbent constituent; a liquid-permeable topsheet that is disposed on the skin contact surface side of the absorbent constituent; and a leakage-preventing sheet that is disposed on at least one of an outside, in the thickness direction, of the absorbent constituent, and an outside, in the width direction, of the absorbent constituent. The leakage-preventing sheet includes a water repelling layer including a nonwoven fabric. The nonwoven fabric of the water repelling layer includes fiber and has an average fiber diameter of 0.5 to 10 ?m. The water repelling layer includes a water repelling section where a group of particles adhere to a surface of the fiber.