Abstract: Systems and methods for monitoring patient vasoactivity are discussed. An exemplary patient monitor system includes a sensor circuit configured to generate a heart sound (HS) metric using a HS signal sensed from a patient, and a vasoactivity monitor configured to monitor vasoactivity, such as degree of vasoconstriction or vasodilation, using the HS metric. The system can provide the monitored vasoactivity to a user to alert patient hemodynamic responses to vasoactive drugs, or initiate or adjust a vasoactive therapy according to the vasoactivity. The system may use the monitored vasoactivity to detect a medical condition such as worsening heart failure, pulmonary edema, or syncope.

Abstract: A blood pressure measurement method and a blood pressure measurement device using the same are provided. The method includes identifying an input value; if the input value is larger than 2, performing, by a blood pressure detector, N times of blood pressure measurement operation sequentially according to the input value, so as to obtain N blood pressure detection values, wherein a value of N is equal to the input value; sorting, according to the size of the N blood pressure detection values, the N blood pressure detection values to obtain N sorted blood detection values, and selecting one or more target sorted blood detection values which is ordered in the middle of the N sorted blood pressure detection values, so as to obtain a blood pressure measurement result value; and outputting, by an output unit, the blood pressure measurement result value.

Abstract: Provided is a method and apparatus for measuring a bio-signal using a radar. An apparatus for measuring a bio-signal using a radar according to an embodiment of the present invention comprises: a first signal acquisition unit for acquiring, from a first radar, a first signal including a first bio-signal measured from a measurement subject, a second signal acquisition unit for acquiring, from a second radar, a second signal including both a second bio-signal and the first bio-signal measured from the measurement subject; a signal synchronization unit for synchronizing the first signal and the second signal and a bio-signal detection unit for calculating the difference between the synchronized first and second signals so as to eliminate the first bio-signal and detect the second bio-signal from the second signal.

Abstract: A non-invasive, optical-based physiological monitoring system is disclosed. In an embodiment, the non-invasive, optical-based physiological monitoring system comprises an emitter configured to emit light into a tissue site of a living patient; a detector configured to detect the emitted light after attenuation by the tissue site and output a sensor signal responsive to the detected light; and a processor configured to determine, based on the sensor signal, a first physiological parameter indicative of a level of pain of the patient.

Abstract: The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.

Abstract: A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a biophysical simulator component (126) configured to determine a fractional flow reserve value via simulation and a traffic light engine (128) configured to track a user-interaction with the computing system at one or more points of the simulation to determine the fractional flow reserve value. A processor (120) is configured to execute the biophysical simulator component to determine the fractional flow reserve value and configured to execute the traffic light engine to track the user-interaction with respect to determining the fractional flow reserve value and provide a warning in response to determining there is a potential incorrect interaction. A display is configured to display the warning requesting verification to proceed with the simulation from the point, wherein the simulation is resumed only in response to the processor receiving the requested verification.

Abstract: The technology relates to a remote ischemic preconditioning system having a cuff configured to contract about a limb of a subject; an actuator connected to the cuff that, when actuated, causes the cuff to contract about the limb of the subject; a controller that controls the actuator to operate according to a treatment protocol that includes a plurality of treatment cycles of contracting and releasing the cuff about the limb of a subject; a first sensor for measuring oxygen saturation level in the blood of the limb; a second sensor for measuring a pulse property in the limb; and a feedback control unit in communication with the controller and configured to receive the oxygen saturation measurement from the first sensor and the pulse property from the second sensor; wherein the feedback control unit is further configured to: compare the oxygen saturation level to a first predetermined value and signal the controller to operate the actuator to further inflate the cuff if the oxygen saturation level is above the

Abstract: Certain aspects of the present disclosure provide methods, apparatus, and computer-readable media for determining hemodynamic stability in a subject. In one example method, an optical signal is transmitted via at least one optical fiber in a set of one or more optical fibers partially disposed in a heart of the subject, wherein the at least one optical fiber in the set is configured to bend with the mechanical movement of the heart. A reflected portion of the optical signal is received via the at least one optical fiber, wherein changes in at least one parameter of the received reflected portion of the optical signal are indicative of the mechanical movement of the heart. A hemodynamic stability of the heart is determined based on the received reflected portion. Hemodynamic stability of the subject may further be determined based on thermal, ultrasound, and/or impedance signals measured in or near the heart.

Abstract: A method of optical flow analysis and a detection device using the analysis method is shown. Examples shown include imaging using a fluid mechanic approach to visualizing flow, for example, in organic tissue. Example shown use apparent displacement in laser speckle patterns.

Abstract: A physiological detection system including an array sensor and a processing unit is provided. The array sensor is configured to output array PPG signals. The processing unit is configured to construct a 3D energy distribution according to the array PPG signals to accordingly identify different microcirculation states.

Abstract: An apparatus, system and method for obtaining hemodynamic characteristics of an individual is disclosed. The apparatus comprises a first sensor arranged to sense a first hemodynamic data from a first radial artery; a second sensor arranged to sense a second hemodynamic data from a second radial artery; and an occlusion device arranged to be positioned around a third major blood vessel where the second major blood vessel branch from, the occlusion device operable to occlude the third major blood vessel for a predetermined period. The apparatus, system and method are suitable for deriving a risk indicator of one or more types of cardiovascular diseases.

Abstract: A fluid pressure detection device capable of accurately detecting a pressure change of a fluid flowing inside a tube includes a substrate, a piezoelectric element formed on the top surface of the substrate, a support body which is annular and surrounds the piezoelectric element and supports the top surface of the substrate, and a lid body which is provided to close the top opening of the support body, and deforms the tube with the bottom surface of the substrate by pressing the substrate through the support body.

Abstract: A monopolar physiological signal detection device and a method of operating the monopolar physiological signal detection device are provided. With a differential amplifier, a delay circuit, a driven-body circuit, and a band-pass filter, the monopolar physiological signal detection device can reduce the common-mode interference induced by supply mains. Moreover, the monopolar physiological signal detection device employs a single electrode to generate electric potentials with different time factors from the same skin surface. Accordingly, consecutive heartbeat related information of a user can be collected even when the user is under natural and comfortable postures.

Abstract: A circuit arrangement for an optical monitoring system comprises a driver circuit configured to generate at least one driving signal for driving a light source and a detector terminal for receiving a detector current. The circuit arrangement further comprises a current source configured and arranged to generate at the detector terminal a reduction current. The reduction current has an amplitude which is given by a base value whenever none of the least one driving signal assumes a value suitable for activating the light source and by a sum of the base value and a reduction value otherwise. The circuit arrangement also comprises a processing unit configured to generate an output signal depending on a combination of the detector current and the reduction current.

Abstract: The present invention relates to a device, system and method for obtaining a vital signal of a subject. To achieved increased robustness against motion, the device comprises a decomposition unit (12) for performing a spectral decomposition of at least two photoplethysmography detection signals being related to a physiological property of the subject and allowing extraction of a vital sign of the subject to obtain two or more spectral components of the detection signals. A weight is determined per spectral component based on an estimate of the relevance of the respective spectral component to the vital sign, derived from a characteristic of said spectral component.

Abstract: A device and a method for assessing the likelihood of an imminent occurrence of cardiac arrest. The device comprises an optical sensor for monitoring the heart rhythm of a person. A Machine Learning Algorithm such as the Artificial neural network (ANN) algorithm analyze features from a trending of pulse intervals in the person's heart rhythm in real time to make the assessment. The device is provided in wearable form, such as a wrist worn device.

Abstract: Certain exemplary embodiments can provide a device that comprises a heart monitor. The device can further comprise GPS hardware and machine instructions. The device comprises a wireless transceiver and a battery. The battery that provides electrical energy to the wireless transceiver and a processor. The processor is constructed to receive signals from the heart monitor and determine that an emergency has occurred.

Abstract: A wrist worn heart rate monitor includes a photoplethysmogram (PPG) sensor and an inertial sensor. Signals from the inertial sensor are used to identify and remove noise from the PPG signals. An initial heart rate value is selected from a number of heart rate candidates that remain in the resulting PPG spectrum and is used to track the heart rate of the user. The PPG spectrum is monitored while tracking the heart rate to determine if the selected initial heart rate value is in error. The PPG spectrum may be monitored by determining a correlation of possible heart rate candidates in each PPG spectrum to the previous heart rate candidates and resetting the heart rate value accordingly. Additionally or alternatively, the PPG spectrum may be monitored by determining when only a single heart rate candidate is present in consecutive PPG spectra and resetting the heart rate value accordingly.

Abstract: Apparatus for monitoring activation in a heart comprises a probe 101, a plurality of electrodes 102 supported on the probe and extending over a detection area of the probe, the detection area being arranged to contact a detection region of the heart. Each of the electrodes 102 is arranged to detect electrical potential at a respective position in the heart during movement of a series of activation wave fronts across the detection region. A processor is arranged to analyse the detected electrical potentials to identify a propagation direction of at least one of the wave fronts, and to generate an output indicative of that direction.

Abstract: The present invention relates to a method to provide a mean temporal spatial isochrone (TSI) feature relating to an ECG feature (wave form) of interest, such as the activation of the heart from a single point (QRS), relative to the heart in a torso while using an ECG measurement from an ECG recording device.

Abstract: An aspect of the present disclosure calculates a phase variance value indicating a degree of variance of a phase in a surrounding of each position in a biological tissue, based on phase values of excitation wave at respective positions in the biological tissue that acts in response to excitation caused by propagation of the excitation wave in the tissue, and generates an analysis map, based on a time series of at least part of the phase variance values at the respective positions. Since the phase variance value indicates the degree of variance of the phase in the surrounding, a position having a large degree of variance of the phase in the surrounding may be specified as a rotation center of rotating excitation wave.

Abstract: Systems and methods for presenting physiologic data to a user are discussed. An exemplary system includes a presentation control circuit configured to generate signal metrics from data subsets of a physiologic signal corresponding to a device-detected presence of a physiologic event. The signal metrics represent characteristics of the physiologic event. The presentation control circuit may determine, from the plurality of data subsets, a target subset of clinical significance, which has the corresponding signal metric satisfying a specific condition. The presentation control circuit may present the recognized target subset over other subsets of the physiologic data. A user may adjudicate the device detection of the physiologic event or adjust device parameters.

Abstract: An injectable composition is described, which is capable of forming an hydrogel for electroencephalography (EEG) recording. The obtained hydrogel and method for its production is also an object of the invention, as well as the use of the injectable composition for EEG recording. The injectable composition comprises: natural or synthetic polymers, preferably alginate; a polymerization initiation system or a cross-linking agent, preferably calcium salts; and at least one ionized salt. The injectable composition can be applied into the electrode cavities of common commercial EEG caps and forms a solid hydrogel shortly after application. When the cap is taken off, the hydrogel either remains inside the electrode cavities, or it breaks into parts that are easily removed from the hair with a comb. It allows a faster and easier cleaning, reduces movement artefacts and also the risks of electrodes short-circuiting due to gel running, hence increasing EEG data reliability.

Abstract: An intention decoding apparatus and a decoding method that quickly and precisely analyze brain waves for decoding an intention decision without requiring an advance brain wave measurement for, for example, a calibration step, and an intention conveyance assist apparatus, an intention conveyance assist system, and a program using a decoding result of the intention decision in the brain. The intention decoding apparatus that analyzes brain waves to decode an intention performs a process to examine a dispersion by classifying brain wave data of event-related potentials corresponding to a plurality of stimulus events into any one stimulus event and the other stimulus events among the plurality of stimulus events, on all the stimulus events, and identifies a classification where the dispersion becomes maximum to identify the one stimulus event in the classification as the intention. The intention conveyance assist apparatus includes a presentation unit that presents a decoding result.

Abstract: An electrocardiogram sensor (400) is provided, comprising an electrode array (100), comprising a substrate (102) interconnecting three or more spaced apart electrodes (101a-c); and a flexible sheet (200) having a greater areal extent than that of the electrode array (100). The flexible sheet (200) is configured to secure the electrodes (101a-c) to the body of a subject.

Abstract: Apparatuses and methods for monitoring a patient for seizure activity and for verifying the contact integrity of electrodes included among an EMG sensor may include generating a test signal of known periodicity and applying the signal to at least one electrode in a sensor system. The test signal may be monitored to verify contact integrity of the electrodes.

Abstract: The present invention relates to a switchable filter device for use in a system for recording electro-physiological signals. The filter device comprises a plurality of recording channels, the recording channels comprising an ablation recording channel. Each recording channel has a patient side terminal at a patient interface and a corresponding recording side terminal at a recording device interface. Each recording channel comprises a first signal path with a first frequency dependent transmission characteristic having a first pass band, a second signal path with a second frequency dependent transmission characteristic different from the first frequency dependent transmission characteristic, the second frequency dependent transmission characteristic having a second pass band overlapping the first pass band, and switching devices operable to switch between the first signal path and the second signal path in response to a control signal indicative of a transient interference signal.

Abstract: An extended wear electrocardiography and physiological sensor monitor is provided. An electrode patch includes an integrated flexible circuit having a single piece of material that includes a longitudinal midsection between upper and lower ends and a mirror image shape of the upper end extending from at least a portion of one side of the upper end that runs substantially parallel to the midsection and folds over the upper end. A receptacle is adhered on an outward surface of the mirror image when the integrated circuit is folded over the upper end. One electrode is positioned on a contact surface of the integrated circuit on the upper end and another electrode is positioned on the contact surface on the lower end. A battery is directly adhered to the outward surface of the mirror image and positioned under the receptacle. A monitor is configured to be removably secured in the receptacle.

Abstract: Disclosed herein are example embodiments of devices, systems, and methods for mechanical fractionation of biological tissue using magnetic resonance imaging (MRI) feedback control. The examples may involve displaying an image representing first MRI data corresponding to biological tissue, and receiving input identifying one or more target regions of the biological tissue to be mechanically fractionated via exposure to first ultrasound waves. The examples may further involve applying the first ultrasound waves and, contemporaneous to or after applying the first ultrasound waves, acquiring second MRI data corresponding to the biological tissue. The examples may also involve determining, based on the second MRI data, one or more second parameters for applying second ultrasound waves to the biological tissue, and applying the second ultrasound waves to the biological tissue according to the one or more second parameters.

Abstract: A catheter device for deploying a local magnetic resonance imaging coil is provided. The catheter device comprises an inner shaft, an outer sheath, and a local magnetic resonance imaging coil. The outer sheath includes a plurality of slits extending in an axial direction proximate a distal end of the outer sheath. The slits separate a portion of the outer sheath into a plurality of struts. The local magnetic resonance imaging coil is disposed between the inner shaft and the outer sheath and is coupled to the plurality of struts. Moving the outer sheath relative to the inner shaft expands the catheter device from a contracted position to an expanded position.

Abstract: In one embodiment, an MRI apparatus includes a memory storing a predetermined program and processing circuitry. The processing circuitry is configured, by executing the predetermined program, to generate a first image having a first phase affected by susceptibility, generate a second image having a second phase affected by both of the susceptibility and flow, and distinguish difference in susceptibility or flow for a pixel of a third image by using the first phase and the second phase or by using a value calculated from the first phase and a value calculated from the first phase, the third image having regions which are substantially same in contrast.

Abstract: In a protocol parameter selection method and corresponding device, when previewing a current sequence in multiple predetermined sequences, a corresponding reference performance index radar chart is displayed in a standard radar chart, according to a reference value of each performance index in multiple performance indices obtained in advance on the basis of the current sequence. The standard radar chart is a radar chart generated using the multiple performance indices as components and using as a standard a standard value of each performance index obtained in advance on the basis of at least one sequence. The method and device also include determining, as a sequence required for scanning, a current sequence selected according to the reference performance index radar chart and a performance index currently of interest.

Abstract: The present invention provides a system and method for multi-phase flow decomposition using electrical capacitance imaging techniques. The present invention provides a system and method to obtain permittivity distributions at a plurality of frequency markers using volume tomography image reconstruction to determine volume fraction of each phase and to produce images of the volume fraction for each phase.

Abstract: An apparatus, method and computer program is described comprising: varying a magnetic field strength of a magnetic field applied to a subject; determining a rate of power loss of the magnetic field, wherein the rate of power loss is a function of the varying magnetic field strength; and providing an output signal based on the determined rate of power loss, wherein the output signal comprises information relating to a conductivity distribution of the subject.

Abstract: An elongate medical device may include an elongate body defining a longitudinal axis, a sensor, and a flexible substrate wrapped so as to form a tube. The sensor may be disposed within the tube, and the tube may be disposed about the longitudinal axis. The elongate body may be a corewire, in an embodiment, and the corewire may extend through the tube. The sensor may comprise a coil, in an embodiment, and the corewire may extend through the coil. The elongate medical device may be a guidewire, in an embodiment.

Abstract: The purpose of the present invention is to enable, even in an endoscopic operation, an operation upon a specific operation site while monitoring the overall surgical site, such as an organ. An artificial magnetic field is generated such that a surgical site of a patient is positioned within a generated three-dimensional artificial magnetic field space. A plurality of magnetic sensors are respectively mounted in a plurality of predetermined locations of the surgical site of the patient. Data of a 3-D image of the surgical site and position information of the mounting locations of the magnetic sensors with respect to the surgical site are stored in a storage unit as position information of the mounting locations with respect to the 3-D image of the surgical site.

Abstract: An apparatus includes a current source, an electronic circuit and a circuit board. The current source is configured to flow an electrical current having a selected frequency between a pair of electrodes coupled to a medical probe. The electronic circuit is configured to measure a single-ended voltage relative to ground that is formed on at least one of the electrodes in the pair in response to the electrical current, and, based on the measured voltage, to assess physical contact between the at least one of the electrodes and tissue. The circuit board includes the current source and the electronic circuit, and includes a layout that produces, at the selected frequency, a predefined capacitance between the current source and ground, thus forming a reference for measurement of the single-ended voltage.

Abstract: A system for light based interrogation of a lung includes a memory, an electromagnetic (EM) board, an extended working channel (EWC), an EM sensor, a light source, a light receptor and a processor. The memory stores a 3D model and a pathway plan of a luminal network and the EM board generates an EM field. The EWC navigates a luminal network of a patient toward a target in accordance with the pathway plan and the EM sensor extends distally from a distal end of the EWC and is configured to sense the EM field. The light source is located at or around the EWC and emits light, and the light receptor is located at or around the EWC and is configured to sense reflected light from airway of the luminal network. The processor converts the reflected light into light based data and identifies a type or density of tissue.

Abstract: A gait training method includes a sensor-based reduction or variation of the weight load (16) in order to improve the gait (21) of an individual (2). A device (1) is used to reduce or vary the weight load (16). The device (1) has a sensor system (3a-e) which detects physical and biometric characteristic data (12), in particular in real-time and automatically via different sensors, and the CPG activity via surrogate signals as additional characteristic data (13) of the individual (2). The characteristic data (12, 13) is used to regulate and/or control a reduction or variation of the weight load (16).

Abstract: There is provided a method of estimating a location and/or orientation of a handheld personal care device with respect to a user of the handheld personal care device. The method includes obtaining measurements of a posture of a part of the body of the user as the user uses the handheld personal care device. The method also includes using the measurements to estimate the location and/or orientation of the handheld personal care device with respect to the user during use of the handheld personal care device based on a predetermined relationship between the location and/or orientation of the handheld personal care device with respect to the user and, exclusively, the posture of the part of the body of the user. A personal care system and a machine-readable medium are also disclosed.

Abstract: A method includes receiving during a first time interval associated with a path of motion of a dynamic body, image data associated with a plurality of images of the dynamic body. The plurality of images include an indication of a position of a first marker coupled to a garment at a first location, and a position of a second marker coupled to the garment at a second location. The garment is coupled to the dynamic body. During a second time interval, an image from the plurality of images is automatically identified that includes a position of the first marker that is substantially the same as a position of a first localization element relative to the dynamic body and a position of the second marker that is substantially the same as a position of the second localization element relative to the dynamic body.

Abstract: The present disclosure includes systems and methods for deriving certain characteristics of the patient's body related to motion from captured motion data. The characteristics may be used to compare the characteristics of the supposed injury to the characteristics of a normally functioning body part as well as the functions of an injured body part. The present disclosure provides a reliable and reproducible way to determine whether a supposed injury is a feigned or exaggerated injury or an actual injury.

Abstract: A fully autonomous system is used to diagnose an ear infection in a patient. For example, a processor receives patient data about a patient, the patient data comprising at least one of: patient history from medical records for the patient, one or more vitals measurements of the patient, and answers from the patient about the patient's condition. The processor receives a set of biomarker features extracted from measurement data taken from an ear of the patient. The processor synthesizes the patient data and the biomarker features into input data, and applies the synthesized input data to a trained diagnostic model, the diagnostic model comprising a machine learning model configured to output a probability-based diagnosis of an ear infection from the synthesized input data. The processor outputs the determined diagnosis from the diagnostic model. A service may then determine a therapy for the patient based on the determined diagnosis.

Abstract: A torque coil 10 includes a first filar configured in an inner layer 14 that is helically wound in a constricted state such that it defines an inner lumen providing access between a proximal and distal end of the torque coil. A second filar is configured in an outer layer 18 that is helically wound over the inner layer in a constricted state. At least one of the first and second filars includes a signal transmitting material surrounded by an isolating material thereby allowing transmission of signals between the proximal and distal end of the torque coil in one of the layers. At least one of the first and second filars includes a torque transmitting material thereby configuring the torque coil to transfer torque from the proximal to the distal end.

Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.

Abstract: A system for calibrating a device for measuring materials concentration in the blood is disclosed. The system may include at least two sets of calibrating elements, each set may include a plurality of calibrating elements. Each of the calibrating elements in the sets may include, a first layer simulating a specific human skin characteristics; and a second layer consisting a specific concentration of one or more materials in the blood. For all calibrating elements in a set the first layer may be the same first layer simulating the same human skin characteristics such that each set of calibrating elements simulate different skin characteristics. Each calibrating element in a set of calibrating elements may include a different second layer consisting a different concentration of the one or more materials. The system may further include a controller.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Abstract: A sweat sensing device (20) comprises at least one sweat generation unit (22) capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit (24, 26) capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit (24, 26) is located above the indirect stimulation region when the sweat sensing device is placed on skin.