Abstract: The present invention provides a method for predicting subject's responsiveness to a corticosteroid medical regimen, prior to the start of the medical regimen, the method comprising the step of determining the amount of miR218-5p in an isolated test sample of the subject, wherein if no miR218-5p amount is present in the sample, it is indicative that the subject will be responder to the medical regimen, and if miR218-5p is detected in the test sample it is indicative that the subject will not respond to the medical regimen. The invention also provides the use of means for determining the amount of miR218-5p for predicting subject's responsiveness to a corticosteroid medical regimen.

Abstract: Whether a fetus has an aneuploidy associated with a first chromosome is detected using ratios of alleles detected in a maternal sample having a mixture of maternal and fetal DNA. DNA from the sample is enriched for target regions associated with polymorphic loci and then sequenced. Polymorphic loci (e.g., single nucleotide polymorphisms) in the target regions with fetal-specific alleles are identified on a first chromosome and on one or more reference chromosomes. A first ratio of the fetal-specific alleles and shared alleles is determined for the loci on the first chromosome. A second ratio of the fetal-specific alleles and shared alleles is determined for the loci on the reference chromosome(s). A third ratio of the first and second ratio can be compared to a cutoff to determine whether an aneuploidy is present, and whether the aneuploidy is maternally-derived or paternally-derived.

Abstract: Methods for diagnosing a cancer in a subject are provided in which a biological sample is provided from a subject including one or more exosomes. The exosomes are isolated from the biological sample and are used to identify a type and/or amount of one or more tumor suppressor miRNAs encapsulated by the exosomes. A measurable difference in the type and/or amount of the tumor suppressor miRNAs as compared to control levels allows for a diagnosis of cancer in the subject. Methods of selecting or modifying a treatment and methods for determining whether to initiate or continue prophylaxis or treatment for a cancer based on the exosomal miRNAs is further provided.

Abstract: A method for in vitro predicting of the outcome of an individual having a multiple myeloma, including the steps of: a) measuring the expression level of at least 5 genes and/or proteins encoded by the 5 genes, the genes being selected in a group including NRP2, REEP1, SV2B, ARRB1, CACNA1G, FBLIM1, FGFR1, IRF6, ITGA9, NOVA2, PPP2R2C, SLC5A1, SORL1, SYT7 and THY1, in a biological sample obtained from the individual; b) calculating a score value from the expression level obtained at step a); c) classifying the individual as having a good prognosis status or a bad prognosis status, by comparing the score value obtained at step b) with a reference score value.

Abstract: Compositions and methods are disclosed for identifying patients for treatment of hematological malignancy.

Abstract: The present invention concerns materials and methods useful for distinguishing between liposarcoma and non-liposarcoma. The invention further includes methods for treating a patient having a lesion from which a sample has been analyzed. The invention also includes arrays useful for distinguishing between liposarcoma and non-liposarcoma.

Abstract: The present invention covers 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyra-zol-5-yl)-1,7-naphthyridine (in the following called “Compound A”), an inhibitor of ATR kinase, for use in a method of treating a hyper-proliferative disease in a subject.

Abstract: The present disclosure provides a method for making an amplified methylome by extending fragments and treating the extended fragments with a methyl transferase and source of methyl groups to transform hemi-methylated double stranded DNA to fully methylated double stranded DNA.

Abstract: This disclosure provides methods of identifying or selecting a patient most likely to benefit from treatment with a telomerase inhibitor, such as e.g. imetelstat, by testing a patient for: a lack of a mutation in each of JAK2, CALR, and MPL; and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. The patient may be suffering from myelofibrosis. The disclosure also provides methods of treating myelofibrosis, which include identifying such patients.

Abstract: The present invention concerns materials and methods for identifying and classifying pancreatic ductal adenocarcinoma (PDAC) precursors or intraductal papillary mucinous neoplasm (IPMN) using messenger RNAs, microRNAs, long non-coding RNAs, radiomic features, radiologic measures of abdominal/visceral obesity, and combinations thereof, as diagnostic markers for integration with clinical management and interventions for personalized care.

Abstract: A highly sensitive and specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect ZIKV nucleic acid in biological samples is described. The disclosed assay is capable of detecting as few as one RNA copy per ?l and can be performed in a clinical or field setting with minimal equipment and technological expertise. Oligonucleotide primers and kits for detecting ZIKV nucleic acid are also described.

Abstract: Compositions and methods useful in identifying and/or selecting maize plants having resistance to northern leaf blight are provided herein. The resistance may be newly conferred or enhanced relative to a control plant. The methods use markers to identify, select and/or construct resistant plants. Maize plants identified, selected, and/or generated by the methods described herein are also provided.

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

Abstract: The present disclosure relates to a microorganism producing L-tryptophan in which the microorganism is modified such that a protein having an L-tryptophan-exporting activity comprising the amino acid sequence of SEQ ID NO: 1 is expressed, and a method for producing L-tryptophan using the microorganism.

Abstract: The aim of the present invention is a method for the preparation of anallergic probiotic bacterial cultures.

Abstract: The present invention relates to genetically engineered yeasts having a heterologous trehalase gene and fermentation processes for using such yeasts. The yeasts can express trehalase in a quantity sufficient to convert significant amounts of trehalose to glucose, thereby improving the yield of the product in a fermentation, and/or reducing or eliminating the need to add exogenous trehalase to the fermentation. The yeasts can also include other heterologous genes for expressing enzymes useful for improving yield and/or for reducing or eliminating the need to add exogenous enzymes to the fermentation.

Abstract: A method of processing raw sugar cane juice, comprising: reducing the pH of the sugar cane juice to a pH at which microbiological activity is substantially eliminated; separating chlorophyll from the sugar cane juice; separating particles having a diameter greater than 0.5 microns from the sugar cane juice; denaturing polyphenol oxidase (PPO) in the sugar cane juice by pasteurisation; separating the denatured polyphenol oxidase from the sugar cane juice.

Abstract: A sterilizing and soaking device for leather manufacturing includes a disinfecting machine (11), a soaking cavity (12) is formed in the disinfecting machine (11), the upper side of the soaking cavity (12) is communicated with an accommodating cavity (13) which penetrates left and right and is upward in opening, a rotating device (101) is arranged in the soaking cavity (12). The cow leather can be better contacted with the disinfectant, the cow leather can be automatically driven to rotate, the disinfection efficiency is increased, the water flow generated by rotation can be used for stirring the disinfectant, so that the disinfectant is uniformly mixed, and the disinfection effect is enhanced.

Abstract: Provided is a block structure that may uniformly distribute a force applied by a charging material, a container including the block structure, and a construction method applied thereto. The block structure includes: a main body having one face extending in one direction and another direction perpendicular to one direction; and a plurality of blocks coupled to one face of the main body and being in contact with each other. Further, an engaged groove and an engaging protrusion are respectively formed on both opposed faces of each of the blocks, the opposed faces facing away each other in at least one of one direction or another direction.

Abstract: An integral high pressure rapid quenching vacuum furnace utilizing an electrical isolation transformer in the blower motor power control system in order to isolate the motor windings, reduce the possibility of gas ionization and eliminate ground faults, particularly when quenching in argon gas, is described. In order to achieve the desired mechanical properties of certain metal alloys being quenched using argon gas as a quenching medium in the high pressure gas vacuum furnace chamber, a 600 HP-460 Volt motor is required. A 460 Volt primary-460 Volt secondary [delta-delta] isolation transformer, having input and output windings separated by an electrostatic shield connected to ground is placed between the power source and the gas blower motor in the quenching chamber filled with argon gas. The 460 Volt power source is connected to a variable frequency drive (VFD) and the VFD is connected to the primary transformer winding. The secondary transformer winding connects 460 Volts to the blower motor windings.

Abstract: A dynamically impacting method comprising simultaneously peening a substrate surface and forming a thin film of metallic glass on the substrate surface for increasing the surface hardness, fatigue resistance, anti-fracture toughness and corrosion resistance of the substrate simultaneously.

Abstract: There are provided a high-strength hot-rolled steel sheet having a tensile strength of 980 MPa or more and a production method therefor. The high-strength hot-rolled steel sheet has a predetermined component composition and a microstructure containing 75.0% or more by area and less than 97.0% by area of a primary phase composed of an upper bainite phase, the primary phase having an average grain size of 12.0 ?m or less, and more than 3.0% by area and 25.0% or less by area of a secondary phase that is a structure composed of one or two of a lower bainite phase and/or a tempered martensite phase, and a martensite phase, in which the number density of grains of the secondary phase having an equivalent circular diameter of 0.5 ?m or more is 150,000 grains/mm2 or less, and the steel sheet has an arithmetic mean surface roughness of 2.00 ?m or less.

Abstract: An aspect of the present invention relates to a wire rod for springs with high strength and excellent corrosion fatigue resistance, in which a combination of Cr, Cu, and Ni content is controlled to an appropriate level, the maximum depth of corrosion pits is set to be below a certain level, and fine carbides containing Mo are set to be at a certain level or greater.

Abstract: The invention relates to a non-oriented electrical steel strip or sheet, in particular for electrical engineering applications, an electrical engineering component produced from such an electrical steel strip or sheet, a process for producing an electrical steel strip or sheet and the use of such an electrical steel strip or sheet in components for electrical engineering applications.

Abstract: In a method for manufacturing a component containing an iron alloy material, a pulverulent pre-alloy is provided. The pre-alloy comprises, in wt. %, 0.01 to 1% C, 0.0.01 to 30% Mn, ?6% Al, and 0.05 to 6.0% Si, the remainder being Fe and usual contaminants. The pulverulent pre-alloy is mixed with at least one of elementary Ag powder, elementary Au powder, elementary Pd powder and elementary Pt powder so as to produce a powder mixture containing 0.1 to 20% of at least one of Ag, Au, Pd and Pt. The powder mixture is applied onto a carrier (16) by means of a powder application device (14). Electromagnetic or particle radiation is selectively irradiated onto the powder mixture applied onto the carrier (16) by means of an irradiation device (18) so as to generate a component from the powder mixture by an additive layer construction method.

Abstract: A steel comprising 0.07 to 0.14 wt. % of carbon, 13 to 15 wt. % of chromium, 1.3 to 1.7 wt. % of molybdenum, 1.5 to 2.0 wt. % of nickel and 1.0 to 1.5 wt. % of manganese and use of the steel for producing screws is provided.

Abstract: An alloy composition comprises that carbon at a concentration of from greater than or equal to about 0.15% by weight to less than or equal to about 0.5% by weight of the alloy composition, manganese at a concentration of from greater than or equal to about 0.1% by weight to less than or equal to about 3% by weight of the alloy composition; silicon at a concentration of from greater than or equal to about 0.1% by weight to less than or equal to about 0.

Abstract: Provided is a hot-dip galvanized steel plate which is applicable as a material for a vehicle outer panel and has an excellent bake hardenability and anti-aging property at room temperature, and a method for manufacturing a hot-dip galvanized steel plate, the method comprising a process including the steps of: winding a hot-rolled steel plate, followed by cooling at a speed of 0.002-0.027° C./sec; cold-rolling the cooled steel plate; continuously annealing the cold-rolled steel plate; and cooling the annealed steel plate in the multi-stage manner of primary to third rounds.

Abstract: A grain-oriented electrical steel sheet having excellent iron loss property is produced from a steel slab containing, by mass %, C: 0.002-0.15%, Si: 2.5-6.0%, Mn: 0.01-0.80%, Al: 0.010-0.050% and N: 0.003-0.020%, when: a heating rate between 500-700° C. In decarburization annealing is not less than 80° C./s, a surface roughness Ra of a work roll in final cold rolling is 0.01-3.0 ?m, a total content of alkaline earth metals to MgO in annealing separator is 0-5 mass %, an average length L in rolling direction of passed crystal grains is not more than 25 mm, a ratio of crystal grains having a length in rolling direction of not less than 0.5 ?m is 40-90%, and an existence ratio of alkaline earth metal sulfides having a size corresponding to circle of not less than 0.5 ?m in a cross section of forsterite film is not more than 0.2/?m per unit length in sheet width direction.

Abstract: This application discloses thin metal strips and methods of making thin metal strip. Particular embodiments of such methods include cooling the thin metal strip to a temperature equal to or less than a bainite or a martensite start transformation temperature BS or MS to thereby form bainite and/or martensite, respectively, within the thin metal strip, reheating the thin metal strip to a reheat temperature equal to or greater than transformation temperature Ac3 and holding the thin metal strip at the reheat temperature for at least 2 seconds and thereby forming austenite within the thin metal strip with at least 75% of austenite grains having a grain size equal to or less than 15 ?m, and rapidly recooling the thin metal strip to a temperature equal to or less than the martensite start transformation temperature MS and thereby providing finer martensite within the thin metal strip from a finer prior austenite.

Abstract: The present disclosure relates to a metal recovery process comprising a solvent extraction process. In an exemplary embodiment, the solution extraction system comprises a plant with a first and second circuit. A high-grade pregnant leach solution (“HGPLS”) is provided to the first and second circuit, and a low-grade pregnant leach solution (“LGPLS”) is provided to the second circuit. The first circuit produces a rich electrolyte, which can be forwarded to a primary metal recovery, and a low-grade raffinate, which can be forwarded to a secondary metal recovery process. The second circuit produces a rich electrolyte, which can also be forwarded to the primary metal recovery process. The first and second circuits are in fluid communication with each other.

Abstract: A method and plant for gold recovery from any gold-bearing ore by low-temperature chlorination, wherein the finely-divided gold-bearing feedstock is chlorinated gaseous chlorine at a temperature of about 245° C. to form a highly volatile chloride compound, which after leaving a reactor is directed to a low-temperature nitrogen plasma unit having a temperature of 900-1100° C., wherein the said compound decomposes and turns into high-purity gold powder, which is cooled with gaseous nitrogen at a cooling reactor's inlet, which is equipped with a water chamber, and collected in a dumping hopper. Some embodiments allow recovery of high-purity 999.9 fine gold using an environmentally friendly, cost effective and inexpensive method implemented on an industrial scale.

Abstract: A Ti-6Al-4V titanium powder alloy composition having enhanced strength resulting from the addition of one or more of the following elements without requiring an increase in oxygen content: Aluminum Iron Nitrogen Carbon The composition may also be used for Ti-6Al-4V titanium alloy starting bar stock.

Abstract: A metal alloy is for use at very high temperature, in particular the metal alloy can be used in a process for the manufacture of mineral wool by fiberizing a molten mineral composition. The metal alloy contains the following elements, the proportions being shown as percentage by weight of the alloy: Cr 20 to 35% Fe 10 to 25% W 2 to 10% Nb 0.5 to 2.5% Ti 0 to 1% C 0.2 to 1.2% Co less than 5% Si less than 0.9% Mn less than 0.9% the remainder consisting of nickel and unavoidable impurities.

Abstract: Provided are: a method for manufacturing a Ni-based heat-resistant superalloy wire having excellent bending workability; and a Ni-based heat-resistant superalloy wire. The method for manufacturing a Ni-based heat-resistant superalloy wire comprises a rod preparation step for preparing a Ni-based heat-resistant superalloy rod; and a rod processing step in which plastic working having a working rate of 40% or less is repeated several times toward the axis from the circumferential surface of the rod at a temperature of 500° C. or lower until the cumulative working rate reaches 60% or more to reduce the cross-sectional area of the rod. A Ni-based heat-resistant superalloy wire obtained by the manufacturing method has a plastic worked or recrystallized microstructure.

Abstract: An aluminum alloy additive manufacturing product and a method manufactures the same. The aluminum alloy additive manufacturing product is formed by molding a raw metal by an additive manufacturing method. The raw metal is made of an aluminum alloy. The aluminum alloy contains Fe and one or more of Mn and Cr. The Fe is an inevitable impurity of 0.3 weight % or less. The one or more of Mn and Cr have a total weight of 0.3 to 10 weight %. The aluminum alloy additive manufacturing product contains any one or more of an intermetallic compound and an aluminum alloy solid solution. The intermetallic compound contains two or more of Al, Mn, Fe, and Cr. One or more elements of Mn, Fe, and Cr are dissolved in the aluminum alloy solid solution.

Abstract: The present invention relates to a method for the economic production of light structural components with high flexibility in the geometry attainable. It also relates to the material required for the manufacturing of those parts. The method of the present invention allows a very fast manufacturing of the parts. The method of the present invention also allows the economic manufacturing of components with intricate internal geometries (such as for example cooling or heating circuits).

Abstract: A material (e.g., an alloy) comprises molybdenum, rhenium, and at least one element selected from the group consisting of tellurium, iodine, selenium, chromium, nickel, copper, titanium, zirconium, tungsten, vanadium, and niobium. Methods of forming the material (e.g., the alloy) comprise mixing molybdenum powder, rhenium powder, and a powder comprising at least one element selected from the group consisting of tellurium, iodine, selenium, chromium, nickel, copper, titanium, zirconium, tungsten, vanadium, and niobium. The mixed powders may be coalesced to form the material (e.g., the alloy).

Abstract: Composites comprising various fractions of ultra coarse (UC) tungsten carbide (WC) and cast carbide (CC), along with composites comprising fractions of UC-WC and CC having various particle size and showing an improved strength and erosion resistance, and methods for making the inventive composites.

Abstract: Mooring chains used in offshore environments are typically formed from carbon steels due to their wear and fatigue resistance properties. Although carbon steels may exhibit robust mechanical properties, they are susceptible to corrosion, which can shorten the usable working lifetime of mooring chains, particularly in a seawater environment. Austenitic steels comprising high percentages of manganese may have comparable mechanical properties to the carbon steels commonly used in mooring chains, yet exhibit less susceptibility to corrosion. Austenitic steels suitable for use in mooring chains and other structures in contact with or exposed to a seawater environment may comprise: 0.4-0.8 wt. % C, 12-25 wt. % Mn, 4-15 wt. % Cr, a non-zero amount of Si<3 wt. %, a non-zero amount of Al<0.5 wt. %, a non-zero amount of N<0.1 wt. %, <5 wt. % Mo, and balance Fe and inevitable impurities.

Abstract: Steel improved in all of the hardenability, toughness, surface-originated micropitting life, and bending fatigue strength and a part manufactured using such steel are provided having predetermined constituents having an Fn1 defined by the following formula (1) of 0.20 to 0.65 and having an Fn2 defined by the following formula (2) of 0.50 to 1.00: Fn1=4.2×[Cr]/(7.0×[Si]+16.0×[Mn])??(1) [Element]: mass % of element Fn2=A1/A2??(2) A1: total area (?m2) of sulfide-based inclusions containing 1.0 mol % or more of Ca with respect to the total number of moles in the sulfides and having a circle equivalent diameter of 1.0 ?m or more in observation regions of a total area of 4.0 mm2 A2: total area (?m2) of sulfide-based inclusions having a circle equivalent diameter of 1.0 ?m or more in observation regions of a total area of 4.

Abstract: A quench and temper steel alloy is disclosed having the following composition in weight percent. C 0.1-0.4 Mn 0.1-1.0 Si 0.1-1.2 Cr 9.0-12.5 Ni 3.0-4.3 Mo ??1-2 Cu 0.1-1.0 Co ??1-4 W ?0.2 max. V 0.1-0.6 Ti ?0.1 max. Nb up to 0.01 Ta up to 0.01 Al ??0-0.25 N 0.1-0.35 Ce 0.006 max. La 0.006 max. The balance of the alloy is iron and the usual impurities found in similar grades of quench and temper steels intended for similar use or service, including not more than about 0.01% phosphorus and not more than about 0.010% sulfur. A quenched and tempered steel article made from this alloy is also disclosed. Further disclosed is a method of making the alloy.

Abstract: A steel alloy and automotive components, such as crankshafts, produced therefrom are provided. The steel alloy includes iron, about 0.34 to about 0.40 weight percent carbon, about 0.8 to about 1.2 weight percent manganese, about 0.40 to about 0.60 weight percent silicon, about 0.04 to about 0.07 weight percent sulfur, about 0.9 to about 1.2 weight percent chromium, about 0.20 to about 0.35 weight percent molybdenum, about 0.08 to about 0.15 weight percent vanadium, and about 0.02 to about 0.06 weight percent aluminum. The steel alloy may also include up to 0.03 weight percent phosphorus, up to 0.25 weight percent nickel, up to 0.20 weight percent copper, up to 0.03 weight percent titanium, up to 0.03 weight percent nitrogen, and up to 0.002 weight percent boron.

Abstract: An essentially lead free steel having, in percent by weight (wt-%): Carbon: 0.39-0.43%; Manganese: 0.75-1.00%; Silicon: 0.15-0.35%; Chromium: 0.80-1.05%; Molybdenum: 0.15-0.25%; at least one of Tellurium: 0.003-0.090 wt-%, Selenium: 0.080-0.2 wt-%, Sulfur: 0.065-0.09% wt-%, and Bismuth: 0.03-0.1 wt-%; and the balance being Fe and normally occurring scrap steel impurities. A method for manufacturing an essentially lead free steel by subjecting a hot-rolled steel product to a heat treatment in which the steel product is subjected to a first temperature for a first duration; the steel product is subjected to a second temperature for a second duration, wherein the second temperature is less than the first temperature; and the steel product is subjected to a third temperature for a third time period, wherein the third temperature is greater than the second temperature; and cooling the steel product. After the heat treatment the steel is cold worked to the desired size.

Abstract: The present invention provides a high thermal conductivity iron-copper (Fe—Cu) alloy and a method of manufacturing the same. The present invention provides an iron-copper alloy containing 55 to 95 atomic % of iron and 5 to 45 atomic % of copper. The present invention also provides an iron-copper alloy manufacturing method including a first step of preparing a melting furnace; a second step of adding iron and copper to the melting furnace and performing dissolution and molten metal formation so as to contain 55 to 95 atomic % of iron and 5 to 45 atomic % of copper based on the weight of the iron-copper alloy; a third step of stabilizing the molten metal; and a fourth step of pouring the stabilized molten metal into a casting mold and performing casting.

Abstract: A system, method, and apparatus for an athlete to variably control the flexibility and stiffness parameters of a piece of athletic equipment to select a desired performance characteristic of the equipment based on the stiffness parameter. According to certain embodiments discussed herein, an item of sporting equipment may be embedded, impregnated, lined, or encased using nitinol components, wherein the nitinol components may themselves be treated using a specific method in order to achieve the desired transformation results, as described below.

Abstract: A method of forming a part from sheet metal alloy is provided, for example, forming a part from aluminium alloy. The method comprises heating (A) the sheet metal alloy to a temperature at which solution heat treatment of the alloy occurs and so as to achieve solution heat treatment. The sheet is cooled (B) at at least the critical cooling rate for the alloy and then placed between dies to form (C) it into or towards the part.

Abstract: The disclosure provides a crucible. The crucible includes a crucible body, wherein the crucible body includes a first crucible component (11) and a second crucible component (12), and a volume of the second crucible component (12) is smaller than that of the first crucible component (11); and the first crucible component (11) includes an opening (111) and a bottom surface (112) facing the opening (111), an end of the second crucible component (12) is connected with the bottom surface of the first crucible component (11), and an internal cavity of the second crucible component (12) connects with an internal cavity of the first crucible component (11). The crucible can prevent evaporation material in the crucible with a large volume from being heated non-uniformly.

Abstract: The present invention relates to a heating assembly, and a heating assembly for a deposition apparatus is provided, the heating assembly comprising: a crucible having a space, which is configured to accommodate a deposition material, formed therein and in which at least one or more nozzles configured to guide the deposition material to an outside are implemented, a coil disposed at an outer side of the crucible and around which a dynamic magnetic field is formed according to a flow of a coil current corresponding to high-frequency power applied to the coil, and a magnetic field focusing member disposed around the coil, wherein an induction current is formed at an outer wall of the crucible due to the dynamic magnetic field, and the crucible is heated by heat generated based on the induction current and an electrical resistance element of the crucible, and the dynamic magnetic field formed around the coil is focused by the magnetic field focusing member so that a quantity of heat generated in the crucible incr

Abstract: A system and method for depositing a coating may comprise a coating chemical reactor, surface activation component, and a deposition component. A target surface may be prepared for deposition with the surface activation component. The coating chemical reactor may comprise a coating chemical dispenser and a coating chemical verifier that prepares the coating chemical for deposition. The coating chemical verifier may utilize an optical excitation source and at least one optical detector, wherein chemical substances are identified by unique signatures composed of binary code. The coating chemical may be received by the deposition component to depositing the coating chemical on the target surface.