Abstract: A method for non-invasive detection of coronary artery disease (CAD). The method includes acquiring a raw ECG signal from a patient, generating a denoised ECG signal by applying a first wavelet transform on the raw ECG signal, generating an artifact-free ECG signal by applying a second wavelet transform on the denoised ECG signal, generating a filtered ECG signal by applying a band-stop filter on the artifact-free ECG signal, extracting an averaged ECG signal of a plurality of averaged ECG signals from the filtered ECG signal, detecting an ST segment in the averaged ECG signal by applying a delineation algorithm on the averaged ECG signal, detecting an isoelectric line in the averaged ECG signal, determining an existence of CAD in the patient responsive to detecting a CAD detection condition, and determining a non-existence of CAD responsive to not detecting the CAD detection condition.

Abstract: A catheter comprising an elongated catheter body, an electrode array distal of the catheter body, the array having a mounting member and at least first and second spine supports. Each spine support includes a base having a planar configuration, and a plurality of spines extending from the base, wherein the first base extends in a first plane and the second base extends in a second plane different from the first plane in the mounting member.

Abstract: Systems and methods for reconstructing heart sounds from heart sound samples taken under a sub-optimal condition, such as at a low sampling rate, are discussed. An exemplary system receives acceleration information from a patient sensed at a first sampling rate, and generate a heart sound ensemble of portions of acceleration information over multiple cardiac cycles. The system can reconstruct a heart sound segment to have a second sampling rate, higher than the first sampling rate, using the generated heart sound ensemble. A heart sound metric can be generated using the reconstructed heart sound segment, and used for detecting a cardiac event, such as a cardiac arrhythmia episode, or a worsening heart failure event.

Abstract: Systems and methods for detecting atrial tachyarrhythmia are discussed. An exemplary atrial tachyarrhythmia detection system includes an arrhythmia detector circuit configured to receive physiologic information of a patient, generate a morphological similarity metric between the received physiologic information and a sinus rhythm (SR) template representing a morphology of conducted sinus beats during normal SR, and generate a morphological variability metric indicative of a variability in morphology between heart beats in the received physiologic information. The arrhythmia detector circuit may detect an atrial tachyarrhythmia episode the morphological similarity and morphological variability metrics.

Abstract: A massage machine includes an electroencephalograph (brain wave measuring device), arranged to measure brain waves of a person being treated, an emotion estimating portion, which, when a massage is being executed, estimates, based on the brain waves measured by the electroencephalograph, an emotion of the person being treated, a question message outputting portion, arranged to vocally output a question message for asking the person being treated whether or not to perform, on the massage currently being executed, a setting change that is in accordance with the emotion of the person being treated estimated by the emotion estimating portion, and a setting changing portion, performing the setting change if a reply of the person being treated to the question message is one that accepts the setting change.

Abstract: A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain is described. The method includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively. A system and apparatus for performing a procedure to identify and treat a nerve that is the source of chronic pain are also described.

Abstract: An electrocardiography device is described that can include a main body, an adjustable cap, and a power switch. The main body can include an electrode of a plurality of electrodes configured to acquire electrical signal from a patient. The adjustable cap can include two electrodes of the plurality of electrodes. The adjustable cap can be rotatable around an axis on the main body to orient the plurality of electrodes on different locations on a body of the patient. The power switch can activate the plurality of electrodes to acquire the electrical signal from the patient. Related apparatuses, systems, methods, techniques and articles are also described.

Abstract: Disclosed is a method for the generation of a consciousness indicator for a non-communicating subject, including the steps of generating an auditory stimulation, receiving an electrocardiographic signal of the subject obtained from a recording during the generation of the auditory stimulation, extracting at least one feature from the electrocardiographic signal and deducing a consciousness indicator from an analysis of the electrocardiographic feature.

Abstract: The present disclosure pertains to a reference slow wave activity metric determination system. Instead of collecting information during sleep sessions without stimulation (e.g., baseline and/or sham sessions) to determine a reference amount of slow wave activity in a subject, the present system is configured to build a model between stimulation properties and slow wave enhancement, and determine the reference amount of slow wave activity in the subject (e.g., corresponding to what would occur during baseline sleep and/or sham sessions) using the model. Advantageously, this approach does not require performance of baseline and/or sham sleep sessions, and enables personalization of the reference amount of slow wave activity, which dynamically increases its accuracy as more information is collected.

Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.

Abstract: A pen like device for contactless imaging of the electrical conductivity of a target tissue during a surgery to different between cancerous cells and normal cells. The device operation is based on the principal of conductivity imaging by a magnetic induction. The device has a cylindrical transmitter coil and two receiver coils that are wound on a cylindrical rod of an electrically insulating material. The measured contactless conductivity through a non-electrically conductive wall of the device's body is displayed on a rotatable screen to help surgeons to make immediate decisions during a surgery.

Abstract: Systems and methods are provided for identifying and locating a plurality of reflector markers implanted within a target tissue region within a patient's body. A probe is provided that is activated to transmit electromagnetic signals into the patient's body, receive reflected signals from the patient's body, and in synchronization with transmitting the electromagnetic signals, deliver light pulses into the patient's body. The markers reflector tags modulate reflected signals from the respective markers based on orthogonal code sequences opening and closing respective switches of the markers to modulate the reflective properties of the markers. The probe processes the return signals to separate the reflected signals based at least in part on the code sequences to identify and locate each of the plurality of reflector tags substantially simultaneously.

Abstract: Disclosed herein is a device detecting volatile organic compounds, such as acetone, using nanostructured K2W7O22 crystals. Methods for detecting a subject in a state of ketosis, such as diabetes, using a volatile organic sensing device are disclosed. A method for synthesizing K2W7O22 nanostructured sensing crystals is further disclosed.

Abstract: Systems and methods provide registration of anatomical points of interest to a surgical navigation system using a camera only without a separate tracked probe. Graphical elements are overlaid on real time images of patient anatomy. Workflow directs the capture of image registration data (pose data) when the graphical elements are aligned. The graphical elements may represent positional features of the camera such as one or more axis positions.

Abstract: Systems and methods for a bedside handle system having two-stage laser motion detection and wireless communication alert. The system detects and sends wireless alerts when a patient sits up and when the patient stands up. The system further includes a mobile app for receiving and displaying the alerts.

Abstract: The disclosure provides a smart strap and a method for defining human posture. The smart strap includes a first shoulder strap, a second shoulder strap, a chest strap, a camera, and a microcontroller. Two ends of the chest strap are respectively connected to the first shoulder strap and the second shoulder strap, and the chest strap includes a stiffness segment. The camera is disposed on a surface of the stiffness segment, faces a first direction, and captures object images of an object on the first direction. The microcontroller receives the object images from the camera, detects a distance between the object and the camera based on the object images, and adjust a screen shown to a wearer of the smart strap according to the distance.

Abstract: A method of determining a CRF level for a user of a fitness tracking system includes receiving activity data from at least one activity sensor carried by the user during a number of workouts, the activity data including distance data for each of the number of workouts, and then generating workout data based on the activity data. The method further includes storing the workout data in a memory, the memory further including demographic data for the user. When the an attribute of the workout data is less than a threshold number, the method includes determining a first CRF level for the user based on a first CRF model. When the attribute of the workout data is greater than the threshold number, the method includes determining a second CRF level for the user based on a second CRF model, and displaying the first and second CRF levels.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: During childbirth process, trauma to an infant can readily arise, ultimately resulting in fetal hypoxia, academia, and brain damage. Such unfavorable conditions can be prevented by measuring the fetus' blood-oxygen level and heart rate. Without a fetal pulse oximeters, blood oxygen level cannot be monitored non-invasively reliably, which reduces the chance for birth complications to be recognized in time. A noninvasive system to implement such goals and maximize the potential welfare of the fetus may include devices to measure oxygen saturation of hemoglobin (SpO2) that have been available for at least 50 years. Such a device may be an oxy probe that uses a trans-reflective method of SpO2 measurement where oxygen saturation data can be transmitted through wire, fiber optics, and or using a radio frequency link, fetal monitor data can be analyzed, compared to existing data base, and or transmitted via radio waves or internet.

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: A method, a system and a computer program product for forecasting blood glucose concentration. One or more features for training a blood glucose concentration forecasting model are determined. The features are determined based on one or more input data parameters associated with a user in a plurality of users. Using the determined one or more features, the blood glucose concentration forecasting model is trained. Using the trained blood glucose concentration forecasting model, one or more expected blood glucose concentrations for the user are generated.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: Embodiments of the invention provide apparatus, systems, and methods wherein pre-event and post-event analyte concentration readings associated with an event are collected and processed to determine a numerical delta. The numerical delta may be displayed on a visual display to aid in a ready determination of the affect that the event (alone or in combination with medication and/or insulin dosages) had on the analyte concentration levels. Medication and/or insulin dosages may be displayed alongside the numerical delta to gauge immediate relationships between numerical delta, dosage, and/or an associated event. Apparatus and systems for calculating and displaying the numerical delta are described, as are other aspects.

Abstract: This fluid evaluation device is provided with an irradiation unit for irradiating a fluid with light, a light reception unit for receiving scattered light from the fluid and outputting a light reception signal, and an estimation unit for estimating at least one from among flow rate and density by mapping input points, which are on a first plane defined by flow rate and frequency and are expressed by light amount information indicating the amount of scattered light included in the light reception signal and frequency information indicating a frequency for a beat signal resulting from the Doppler shifting of the light included in the light reception signal, onto a second plane defined by fluid flow rate and fluid density.

Abstract: The invention provides a pulse oximetry sensor for attachment to the lower half of the palm or the ulnar edge of the palm. The sensor may be portable, untethered and in some instances, disposable. The features of the sensor make it effective in stable, chronic or emergency medical settings.

Abstract: The present disclosure provides a method of using a sweat sensing device to determine a kidney profile for an individual. The method includes taking concentration, ratio, and trend measurements of one or more kidney biomarkers in the individual's sweat, along with other contemporaneous device measurements to inform sweat rate, skin temperature, sweat sample pH, or other factors. The method further considers these measured values in the context of external information about the individual, and uses such information to develop a kidney function profile or a kidney injury profile indicative of the physiological state of the individual.

Abstract: A system for comprehensive multisensory vision, hearing, and cognitive screening includes a headwear test unit comprising a configurable video, audio, and hand-gesture capable testing device. The system further includes an identification, anonymization and security module, a patient interface, an operator interface, a communication module, and a unit charging and calibration module and/or station. An adaptive real-time compiler compiles sequences of optometric hearing and cognition tests. A cloud-based web service module is configured for storing encrypted personal optometric information. A machine learning module is operatively connected to the cloud-based web service module.

Abstract: A phrenic nerve pacing monitor assembly for a cryogenic balloon catheter system used during a cryoablation procedure, which monitors movement of a diaphragm of a patient, includes a pacing detector and a safety system. The pacing detector directly monitors movement of the diaphragm of the patient to detect when phrenic nerve pacing is occurring. Additionally, the pacing detector generates monitor output based on the movement of the diaphragm of the patient. The safety system receives the monitor output and based at least in part on the monitor output selectively provides an alert when movement of the diaphragm of the patient is atypical. The safety system is configured to provide the alert only while at least one of (i) phrenic nerve pacing is occurring, and (ii) cryoablation is occurring.

Abstract: Disclosed is an apparatus for therapy of cognitive impairment. In an embodiment, the apparatus includes a headwear cognition therapy unit comprising a housing having a display, a camera, a microphone, a speaker, a communication module configured to exchange data with an external service unit, an accelerometer, a three-axis gyroscope, and a memory storing data comprising firmware. The firmware is configured to use the speaker and the display to implement cognitive therapy and to detect when a patient is moving and switch the unit from VR mode to AR mode or transparent mode such that the patient can see his/her surroundings.

Abstract: Embodiments for determining the cardiac health of a subject using voice analysis are disclosed. In an embodiment, a method comprises receiving a voice sample from the subject. The method further comprises determining one or more characteristics of the voice sample. And, the method further comprises determining the subject's cardiac health based on the one or more characteristics.

Abstract: Methods, systems, and techniques for providing neurofeedback and for training brain wave function are provided. Example embodiments provide a Brain Training Feedback System (“BTFS”), which enables participants involved in brain training activities to learn to evoke/increase or suppress/inhibit certain brain wave activity based upon the desired task at hand. In one embodiment, the BTFS provides a brain/computer interaction feedback loop which monitors and measures EEG signals (brain activity) received from participant and provides feedback to participant. The BTFS may use an FFT based system or machine learning engines to deconstruct and classify brain wave signals. The machine learning based BTFS enable optimized feedback and rewards, adaptive feedback, and an ability to trigger interventions to assist in desired brain transitions.

Abstract: The present invention provides systems, methods, and articles for stress reduction and sleep promotion. A stress reduction and sleep promotion system includes at least one remote device, at least one body sensor, and at least one remote server. In other embodiments, the stress reduction and sleep promotion system includes machine learning.

Abstract: A patient treatment unit for analyzing and treating abnormality of human or animal tissues, includes a display; a pulse generator circuit that outputs a sequence of electrical pulses at a pulse frequency, the electrical pulses having a pulse width, the pulse generator controlling the pulse frequency and the pulse width of the electrical pulses; a pair of probes for contacting a body of a patient and electrically coupled to the pulse generator; and a voltage and current sensing circuit that senses a voltage or a current via the probes when contacting the body of the patient.

Abstract: A physical area network described herein enables significantly improved health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and information.

Abstract: A physical area network described herein enables significantly improved health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and information.

Abstract: A physical area network described herein enables significantly improved health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and information.

Abstract: A method for analyzing neuropharmacology of a drug, including the steps of providing a set of brain activity maps representing changes of a brain activity of a living species under an influence of a plurality of known drugs each consisting of a known chemical structure; clustering the set of brain activity maps to form a plurality of functional classifiers; and classifying a brain activity map associated with a chemical compound using the functional classifiers so as to predict a neuropharmacology of the chemical compound.

Abstract: A method of treating a host with a medication, comprising assigning a unique identifier to a host treatment apparatus; assigning a unique identifier to the host; storing the unique host identifier and the unique host treatment apparatus identifier on at least one remote server of a network and associating the unique host identifier and the unique host treatment apparatus identifier on the at least one remote server such that the unique host identifier and the unique host treatment apparatus identifier are exclusively associated to each other; activating the host treatment apparatus; coupling the host medication delivery device to the host; operating the host medication delivery device to deliver the medication contained in the host medication delivery device to the host; and operating the host treatment apparatus such that the host treatment apparatus communicates wirelessly to the at least one remote server an operational status of the host medication delivery device.

Abstract: The subject of the invention is a sports physiological measuring system and method for the monitoring of the aerobic and anaerobic metabolic energy generating system and the autonomic nervous system, primarily during physical exercise.

Abstract: The present invention involves systems and related methods for performing percutaneous pedicle integrity assessments involving the use of neurophysiology.

Abstract: A wireless wearable sensor device, system, method, and non-transitory computer readable medium for screening for structural heart disease based on electrocardiogram, phonocardiogram, and/or accelerometer signals on a patient's skin surface.

Abstract: Methods and apparatuses are provided for measuring a vital signal. An application is executed to output vital information of a user wearing an electronic device. Instructions are output that guide inhalation and exhalation of the user based on the executed application. At least one vital signal for the user is obtained while outputting the instructions. Vital information corresponding to the obtained at least one vital signal is output.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing that is configured to anchor the device to a muscle, a bone, and/or a first tissue, and a first prong with a proximal end attached to the housing and a distal end extending away from the housing that is configured to contact a first lung. A first electrode on the device is configured to contact the first lung, and a second electrode on the device is configured to contact the first lung or a second lung. Sensing circuitry in the housing in electrical communication with the first electrode and the second electrode is configured to measure an impedance in the first lung and/or the second lung, and/or a transthoracic impedance across the first lung and the second lung.

Abstract: Detecting user contact with one or more electrodes of a physiological signal sensor can be used to ensure physiological signals measured by the physiological signal sensor meet waveform characteristics (e.g., of a clinically accurate physiological signal). In some examples, a mobile and/or wearable device can comprise sensing circuitry, stimulation circuitry, and processing circuitry. The stimulation circuit can drive one or more stimulation signals on one or more electrodes, the resulting signal(s) can be measured (e.g., by the sensing circuitry), and the processing circuitry can determine whether a user is in contact with the electrode(s). Additionally or alternatively, in some examples, mobile and/or wearable device can comprise saturation detection circuitry, and the processing circuitry can determine whether the sensing circuitry is saturated.

Abstract: Detecting user contact with one or more electrodes of a physiological signal sensor can be used to ensure physiological signals measured by the physiological signal sensor meet waveform characteristics (e.g., of a clinically accurate physiological signal). In some examples, a mobile and/or wearable device can comprise sensing circuitry, stimulation circuitry, and processing circuitry. The stimulation circuit can drive one or more stimulation signals on one or more electrodes, the resulting signal(s) can be measured (e.g., by the sensing circuitry), and the processing circuitry can determine whether a user is in contact with the electrode(s). Additionally or alternatively, in some examples, mobile and/or wearable device can comprise saturation detection circuitry, and the processing circuitry can determine whether the sensing circuitry is saturated.

Abstract: A biosensor calibration structure is provided that includes at least two electrode structures in which at least one of the electrode structures has a non-random nanopattern on the sensing surface which provides a different sensing surface area than at least one other electrode structure. The at least one other electrode structure may be non-patterned (i.e., flat) or have another non-random nanopattern on the sensing surface. A biological functionalization material such as, for example, glucose oxidase or glucose dehydrogenase, can be located on at least the sensing surface of each electrode structure. The biosensor calibration structure can be used within a biosensor calibration method.

Abstract: A needle member includes: a tubular side wall through which a hollow portion extends in a longitudinal direction. An opening portion connected to the hollow portion extends laterally through the tubular side wall. The tubular side wall comprises a side wall reinforcement portion located at a position opposing the opening portion, wherein the hollow portion is interposed between the opening portion and the side wall reinforcement portion.

Abstract: A conductor arrangement is provided for connection to a miniature sensor. First and second conductor wires are spaced by a spacer. The maximum lateral dimension of the conductor arrangement, perpendicular to the wire length direction, is less than 500 ?m. The spacing means that wire bending processes do not need to be carried out in order to make connection to the miniature sensor.

Abstract: A catheter adapted for greater mapping resolution and location precision has a basket-shaped, high density electrode assembly for large-area mapping, and an integrated distal tip providing an array of ultra-high density microelectrodes for acute focal mapping. The basket-shaped electrode assembly 18 has a plurality of electrode-carrying spines and the distal tip has a nonmetallic, electrically insulating substrate body with indentations in which microelectrodes are positioned in a manner that the outer surface is generally flush with the outer surface of the substrate body to present a generally smooth, atraumatic distal tip profile.

Abstract: A method for confirming effectiveness of therapy provided by an insulin infusion system comprising a computing device communicatively coupled to an insulin delivery pump and a blood glucose sensor, is provided.