Patents Issued in April 14, 2020
  • Combination therapy for the treatment of glioblastoma
    Patent number: 10617755
    Abstract: This invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: April 14, 2020
    Assignee: Genentech, Inc.
    Inventors: Carlos Bais, Richard Bourgon, Heidi Phillips, Thomas Sandmann
  • Drug regimen for treatment of cerebral ischemia
    Patent number: 10617756
    Abstract: Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (VEGF-RST) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: April 14, 2020
    Assignee: Shimojani, LLC
    Inventors: Lawrence M. Kauvar, Damir Janigro
  • Methods for treating multiple myeloma
    Patent number: 10617757
    Abstract: The present disclosure provides methods of treating multiple myeloma in an individual, the methods comprising genotyping an HLA allele and a KIR allele in the individual; and, depending on the outcome of the genotyping, administering a multiple myeloma therapy to the individual. In some embodiments, the multiple myeloma therapy comprises an anti-CD38 antibody, lenalidomide, and dexamethasone. The present disclosure provides methods for selecting a multiple myeloma patient for a multiple myeloma therapy. The present disclosure provides methods for identifying a multiple myeloma patient as likely to experience a beneficial clinical outcome from a multiple myeloma therapy.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: April 14, 2020
    Assignee: The Regents of the University of California
    Inventor: Jeffrey M. Venstrom
  • Anti-cancer vaccine combination
    Patent number: 10617758
    Abstract: The invention relates to an anti-cancer vaccine combination. Particularly, the invention relates to a pharmaceutical combination comprising a PD-L1/PD-1 expression inhibitor in combination with a viral antigen-associated vaccine.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: April 14, 2020
    Assignee: Global Biopharma, Inc.
    Inventors: Huei Lee, Yu-Ju Huang
  • Light-stimulated release of cargo from oligonucleotides
    Patent number: 10617759
    Abstract: The invention provides oligonucleotide conjugates including a photolabile crosslinker attached to a cargo moiety, e.g., a therapeutic or diagnostic agent. The invention further provides reagents useful in the preparation of such conjugates and methods of their use.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 14, 2020
    Assignee: Trustees of Boston University
    Inventors: Xue Han, Richie E. Kohman, Susie S. Cha
  • Composition for target-specific photothermal therapy
    Patent number: 10617760
    Abstract: Provided are a composition for target-specific photothermal therapy and a method of photothermal therapy using the composition and more particularly, a method of photothermal therapy for selectively killing inflammatory cells by using the composition for target-specific photothermal therapy comprising carbon nanotubes coated with dextran. According to the present invention, the composition for photothermal therapy comprising the carbon nanotubes coated with dextran is absorbed only into desired target cells, i.e., inflammatory cells, and causes thermotherapeutic action through light irradiated from an external light source, while not damaging cells except for inflammatory cells. The method of photothermal therapy using the composition for photothermal therapy has advantages of minimizing side effects and maximizing therapeutic effects.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: April 14, 2020
    Assignee: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Woo Jae Kim, Jo-Eun Um
  • Compositions and solutions for colon cleansing
    Patent number: 10617761
    Abstract: The invention relates to polysiloxanes contained as defoaming agents, amongst other things, in medicinal compositions such colon cleansing solutions and antiflatulants. The aim of the invention is to further improve the defoaming effect of polysiloxanes and also the compatibility of the agents. According to the invention, the use of calcium sulphate increases the defoaming effect of dimeticon or simeticon as polysiloxane defoaming agents. The invention also relates to PEG-containing colon cleaning solutions based thereon.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: April 14, 2020
    Assignee: REGALISMONS S.A.
    Inventor: Uwe Willi Albrecht
  • Devices and methods and agent-assisted medical procedures
    Patent number: 10617762
    Abstract: Various embodiments of bulking or cushioning agents or material and related medical devices and methods are disclosed. For example, a method of performing a medical procedure in a tract of a body may include injecting a material in a liquid phase proximate a target site between a first tissue layer and a second tissue layer, allowing the material to transition from the liquid phase to the gel phase in response to a raise in temperature of the material to approximately at or above the predetermined temperature, and performing a surgical procedure on the target site. The material may have the liquid phase at temperatures below a predetermined temperature and a gel phase at temperature approximately at or above the predetermined temperature.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: April 14, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Paul Scopton, Samuel Zhong, Yem Chin
  • Compositions and methods for the treatment of presbyopia
    Patent number: 10617763
    Abstract: The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine and a cryoprotectant. The compositions optionally contain a cycloplegic agent, a surfactant, a viscosity enhancer, an osmolarity modifier and a preservative.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: April 14, 2020
    Assignee: PRESBYOPIA THERAPIES, LLC
    Inventors: Gerald Horn, Lee Nordan
  • Lyophilized anti-tissue factor antibody-drug conjugates
    Patent number: 10617764
    Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: April 14, 2020
    Assignee: GENMAB A/S
    Inventors: Jesper Valbjørn, Xiaona Jing, Kelly Ann Roby, Timothy Warren Paul, Gregory Allan Sacha, Nathan Alan Pease, Bodil Willumsen
  • Additive systems for use in protein PEGylation
    Patent number: 10617765
    Abstract: The present disclosure provides an additive system for use in protein PEGylation. The additive system includes p-aminobenzoic hydrazide used either alone or in combination with aromatic amines, such as 3,5-diaminobenzoic acid, or with ammonium salts such as ammonium chloride or ammonium acetate. The disclosed additive combination provides several benefits including increased reaction rates, higher yields and reduction in the aminoxy-PEG equivalents required to complete the conjugation reaction. Typical reactions can be run by combining the additive or additive system with a solution of a protein and aminoxy-PEG reagent. The solution is adjusted to pH 4 and held at 20-25° C. without stirring until completion, typically within 24 hours.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: April 14, 2020
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Matthew R. Hickey, Antonio Ramirez
  • Multivalent meningococcal polysaccharide-protein conjugate vaccine
    Patent number: 10617766
    Abstract: The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: April 14, 2020
    Assignee: Sanofi Pasteur Inc.
    Inventor: Robert P. Ryall
  • Compositions and methods for oral delivery of therapeutic cargo
    Patent number: 10617767
    Abstract: The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: April 14, 2020
    Assignee: Applied Molecular Transport Inc.
    Inventors: Randall J. Mrsny, Tahir Mahmood
  • Engineered exosomes for the delivery of bioactive cargo using transmembrane tetraspanins
    Patent number: 10617768
    Abstract: Engineered exosomes for the delivery of bioactive cargo are provided. The exosomes incorporate a tetraspanin transmembrane anchoring scaffold onto the membrane of the exosome. The tetraspanin transmembrane anchoring scaffold has a C-terminal attachment site in the inner-vesicle space of the exosome, a N-terminal attachment site in the inner-vesicle space or the outer-vesicle space, and/or a loop attachment site in the outer-vesicle space. Peptides can be attached to the different attachments sites in any form or combination. Tetrapanins naturally anchor on the exosome membrane, are biocompatible, and allow for robust loading and delivery of bioactive cargos in mammalian system.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 14, 2020
    Assignee: Santa Clara University
    Inventors: Biao Lu, Conary Meyer, Joseph Losacco, Zachary Stickney
  • Bacterium-contained hydrogel and method of making the same
    Patent number: 10617769
    Abstract: The present disclosure provides a bacterium-contained hydrogel including: hydrogel, bacteria, and metabolites. The hydrogel includes a plurality of polymer chains crosslinked with each other, and each of the polymer chains include at least one polyethylene glycol chain. The bacteria are located in the hydrogel, and the bacteria use the polymer chains as a carbon source for fermentation. The metabolites are produced from the fermentation of the bacteria using the polymer chains as a carbon source. The metabolites distribute in the hydrogel. The present disclosure also provides a method for making bacterium-contained hydrogel.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: April 14, 2020
    Assignee: TCI Co., Ltd.
    Inventor: Chun-Ming Huang
  • AAV vector for treatment of Friedreich's ataxia
    Patent number: 10617770
    Abstract: Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating Friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve use of a FXN coding sequence, a truncated FXN 3? UTR, and a promoter.
    Type: Grant
    Filed: April 23, 2016
    Date of Patent: April 14, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Manuela Corti, Barry John Byrne
  • Adenoassociated virus vectors for the treatment of mucopolysaccharidoses
    Patent number: 10617771
    Abstract: The present invention provides new Adeno-associated virus-derived vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidoses Type II.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 14, 2020
    Assignees: UNIVERSITAT AUTÓNOMA DE BARCELONA, ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Maria Fàtima Bosch Tubert, Virginia Areba Haurigot, Sandra Motas Mallol
  • Hsp9O-targeted inflammation and infection imaging and therapy
    Patent number: 10617772
    Abstract: The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: April 14, 2020
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Mark Dunphy, Gabriela Chiosis
  • Antibodies against the MUC1-C/extracellular domain (MUC1-C/ECD)
    Patent number: 10617773
    Abstract: The present disclosure is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 14, 2020
    Assignees: DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
    Inventors: Donald W. Kufe, Surender Kharbanda
  • Cover with disinfecting illuminated surface
    Patent number: 10617774
    Abstract: A light emitting cover which inactivates microorganisms for covering a high touch surface is disclosed. The light emitting cover includes a body having an interior configured to cover at least a portion of the high touch surface and an exterior surface configured to be disinfected. At least an exterior portion of the body is transparent or translucent. A light emitter operably is coupled to the body for emitting a light through the exterior surface. The light exiting the exterior surface has at least a portion thereof having a wavelength in a range of 380 to 420 nanometers to disinfect the exterior surface.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 14, 2020
    Assignee: Vital Vio, Inc.
    Inventors: Cori Winslow, Colleen Costello, Nicholas Jones, Robert Barron, William Grambo, Jorel Lalicki
  • Lighting device that deactivates dangerous pathogens while providing visually appealing light
    Patent number: 10617775
    Abstract: A lighting device configured to deactivate MRSA bacteria in air in an environment, including a housing; a light-emitting diode (LED) configured to emit light having a wavelength of about 470 nm; a light converting phosphor coating; wherein a first component of the light emitted by the LED travels through the light converting phosphor coating without alteration, and a second component of light emitted by the LED is converted by the converting phosphor coating into light having a wavelength of greater than 500 nm; wherein the first component of the light has a minimum integrated irradiance of 0.01 mW/cm2; wherein the first component of the light emitted by the LED and the second component of light emitted by the LED mix to form a combined light, with the combined light being visible light; and means for directing the combined visible light to the air in the environment.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: April 14, 2020
    Assignee: KENALL MANUFACTURING COMPANY
    Inventors: James W. Hawkins, Nathan D. Heiking, Patrick J. Marry
  • Gas delivery system and method of sanitizing the gas flow path within a gas delivery system
    Patent number: 10617776
    Abstract: A gas delivery system (50) for delivering a flow of breathing gas to a patient (54) includes a blower assembly (100) structured to generate the flow of breathing gas. The blower assembly includes a gas flow path including an inlet manifold, an assembly (130) structured to adjust a pressure and/or flow rate of the flow of breathing gas, and an outlet manifold structured to be coupled to a patient circuit. The gas delivery system additionally includes a light system structured to generate sanitizing light and deliver the sanitizing light to one or more internal surfaces of at least one of the inlet manifold, the assembly and the outlet manifold for sanitizing the one or more internal surfaces.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: April 14, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: John Raymond Pujol, David Scott Arnold, John Michael Cosnek, Christopher Randall Baker, Mark William Dimatteo
  • Sanitizing door handle with external fluid container
    Patent number: 10617777
    Abstract: Various implementations of the invention are directed toward a sanitizing door handle and/or components of such sanitizing door handle. Some implementations of the invention are directed toward a manual sanitizing door handle while some implementations of the invention are directed toward an auto-sanitizing door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto an exterior surface of the sanitizing door handle in connection with an operation of the door handle to sanitize the door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto a user's hand(s) in connection with an operation of the door handle to sanitize the user's hand(s).
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 14, 2020
    Assignee: KleanTouch LLC
    Inventor: Michael Rafko
  • Self-sterilizing package and methods for making and using the same
    Patent number: 10617778
    Abstract: The presently disclosed subject matter provides a system and method for sterilizing a wide variety of products. Specifically, in some embodiments, the presently disclosed subject matter is directed to a package that is capable of self-sterilizing by initiating sterilizing conditions inside the package interior without the necessity of being treated with an externally-supplied sterilizing medium. Particularly, the disclosed package includes at least one dual-layer lid that comprises inner and outer layers and an interstitial space that houses a sterilizing gas-producing component.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 14, 2020
    Assignee: Cryovac, Inc.
    Inventors: William P. Roberts, Joshua D. Wofford, Charles D. Robnett
  • Vacuum exhaust system of sterilizer
    Patent number: 10617779
    Abstract: The invention relates to a vacuum exhaust system of a sterilizer, comprising: a sterilization chamber; a first vacuum pump connected to one side of the sterilization chamber; an oil mist trap section for exhausting steam incoming from the sterilization chamber via the first vacuum pump; and a second vacuum pump connected to the first vacuum pump and the oil mist trap section. The vacuum exhaust system of a sterilizer according to the invention comprises the second vacuum pump connected to the first vacuum pump and the oil mist trap section, wherein by turning the second vacuum pump on to apply a vacuum to the operating oil in the first vacuum pump, thereby providing a certain pressure for evaporating water in liquid state to the first vacuum pump, the invention can vaporize the water vapor trapped in the operating oil in the first vacuum pump.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: April 14, 2020
    Assignee: CMTECH CO. LTD.
    Inventors: Heung Sik Min, Young Keun Ahn, Sung Jin Yang, Jin Woo Min
  • Disinfectant caps
    Patent number: 10617780
    Abstract: A cleaning device for LADs, and other such threaded devices, comprising a cap and a cleaning agent. The cap comprises a casing having an opening to an interior cavity. A threaded coupling mechanism is located on the inner surface of the casing proximate the opening. The coupling mechanism has retention features that provide localized pressure points on the threads of the LAD to accommodate thread variance and reduce the chance of premature disengagement.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: April 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Alan R. Dombrowski, Timothy C. McFarland, John C. Detloff
  • Device for catalytic diffusion of a fragrance
    Patent number: 10617781
    Abstract: Some embodiments are directed to a device for catalytically diffusing a fragrance or active substances, wherein the device includes a bottle with a base, and containing a liquid including a fragrance; a catalytic combustion burner mounted on the base; a capillary wick attached to the burner and partially submerged in the liquid; and a closing cap removably mounted on the base and covering the burner. The cap includes a sealing means bearing against a periphery of a top of the base.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: April 14, 2020
    Assignee: PRODUITS BERGER
    Inventors: Vincent Cholet, Corinne Gerard
  • Flowing fluid disinfection method and disinfector
    Patent number: 10617782
    Abstract: A method for disinfecting a fluid includes emitting UV light into a flowing fluid pillar along its axial direction. The flowing fluid pillar is surrounded by and in contact with a fluid medium having a refractive index lower than that of the fluid to be disinfected so that total internal reflection occurs when the UV light travels within the flowing fluid pillar. Also provided is a UV disinfector for disinfecting a flowing fluid.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 14, 2020
    Assignee: BOLB INC.
    Inventors: Jianping Zhang, Ling Zhou, Ying Gao
  • Air purification assembly and method of using same
    Patent number: 10617783
    Abstract: An air purification assembly is described. The air purification assembly includes an intake portion, a flow apparatus coupled to the intake portion; and a chamber portion coupled to the flow apparatus. The intake portion includes a surface and at least one first opening in the surface such that the intake portion is enabled to receive contaminated air flow through the at least one first opening. The chamber portion includes at least one second opening and further comprises an activated nonmetallic element and an ultraviolet (UV) light assembly. The flow apparatus is adapted to draw contaminated air into the air purification assembly through the at least one first opening and direct the contaminated air out of the air purification assembly through the second openings.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: April 14, 2020
    Assignee: Scientific Air Management, LLC
    Inventor: Dana Leonaggeo
  • Anti-microbial articles and methods of using same
    Patent number: 10617784
    Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate overlaying the occlusive layer, wherein the substrate having two opposing major surfaces; a metal oxide layer overlaying the substrate, wherein the metal oxide layer comprises a metal oxide and wherein the metal oxide layer comprises less than 40 wt. % non-oxidized metal; and a metal layer overlaying the metal oxide layer.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: April 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Ta-Hua Yu, Döne Demirgöz, Junkang J. Liu, Badri Veeraraghavan, Narina Y. Stepanova
  • Collagen reinforced tissue grafts
    Patent number: 10617785
    Abstract: This invention is directed to a multi-layered tissue graft comprising a collagen layer and at least one separated and washed placental tissue component and/or umbilical cord component, wherein the collagen is human collagen substantially free of non-human antigens.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: April 14, 2020
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Adhesive article comprising a poly(meth)acrylate-based primer layer and methods of making same
    Patent number: 10617786
    Abstract: An adhesive article comprising a poly(meth)acrylate-based primer layer and methods of making same. The article can include a backing, a primer layer located on a first major surface of the backing, and a silicone-based adhesive located on the primer layer. The primer layer can be derived from a primer precursor comprising poly(meth)acrylate functionalities. The method can include applying a primer precursor onto a first major surface of a backing, the primer precursor comprising a compound comprising poly(meth)acrylate functionalities; irradiating the primer precursor; applying an adhesive on the irradiated primer precursor; and irradiating the adhesive and the irradiated primer precursor to form a primer layer located between the adhesive and the first major surface of the backing.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: April 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Bruce D. Kluge, Junkang J. Liu, Robin E. Wright, Timothy M. Dietz, Melissa A. Iseminger, Margaux B. Mitera, Daniel O. Manalo
  • Biopolymer compositions, scaffolds and devices
    Patent number: 10617787
    Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: April 14, 2020
    Assignee: EMBODY INC.
    Inventors: Michael Francis, Nathan Kemper, Hilary Wriggers
  • Collagen permeated medical implants
    Patent number: 10617788
    Abstract: The invention herein relates to the field of attaching and securing manmade material onto or into bone in correcting bone defects by implanting stress-bearing bone replacements. In particular, the invention relates to applying a coating of collagen securely onto the implant to ensure the collagen material will not be removed from the implant during installation, such as screwing the anchor into the bone. This addresses the removal of the coatings by the scraping action of the bone on the soft collagen. In the past, it has not been possible to provide adequate adhesive strength to the bone collagen/implant interface or the cohesive force of the collagen itself to prevent the removal of the coating by the abrasive action between bone and known implants.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: April 14, 2020
    Assignee: McCoy Enterprises, LLC
    Inventor: Annick F McCoy
  • Hydrophilic coatings and methods of forming the same
    Patent number: 10617789
    Abstract: Hydrophilic coatings including a base coat layer and a top coat layer wherein at least one of the base coat and top coat compositions that form the hydrophilic coatings comprises a diacrylate compound have a number average molecular weight less than 1000.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: April 14, 2020
    Assignee: Hollister Incorporated
    Inventors: John P. O'Mahony, David J. Farrell
  • Decellularized biomaterial from non-mammalian tissue
    Patent number: 10617790
    Abstract: The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: April 14, 2020
    Assignee: ISE Professional Testing & Consulting Services, Inc.
    Inventor: Ryanne Early
  • Injectable hydrogels from microfiber suspensions
    Patent number: 10617791
    Abstract: Provided is a hydrogel. The hydrogel includes a liquid and a plurality of microfibers suspended in the liquid as an entangled network. The entangled network includes physically entangled microfibers that are mechanically interlocked.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: April 14, 2020
    Assignees: THE TRUSTEES OF PRINCETON UNIVERSITY, UNIVERSITÀ DI NAPOLI “FEDERICO II” DIPARTIMENTO DI INGEGNERIA CHIMICA, DEI MATERIALI E DELLA PRODUZIONE INDUSTRIALE
    Inventors: Janine K. Nunes, Antonio Perazzo, Stefano Guido, Howard A. Stone
  • Compositions and methods for treating and preventing tissue injury and disease
    Patent number: 10617792
    Abstract: The present invention provides novel compositions comprising multipotent cells or microvascular tissue, wherein the cells or tissue has been sterilized and/or treated to inactivated viruses, and related methods of using these compositions to treat or prevent tissue injury or disease in an allogeneic subject.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: April 14, 2020
    Assignee: MicroVascular Tissues, Inc.
    Inventors: Dale R. Peterson, Ralph-Heiko Mattern, Corey Wilson, Kevin L. Ohashi
  • Delivery of hydrophobic active agent particles
    Patent number: 10617793
    Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: April 14, 2020
    Assignee: Surmodics, Inc.
    Inventors: Joram Slager, Toni M. Heyer, David E. Babcock
  • Macroinitiators for hydrophilic coatings on latex and applications thereof
    Patent number: 10617794
    Abstract: Provided herein are methods comprising the use of a macroinitiator and application protocols to apply a hydrophilic coating to latex, or natural rubber, and compositions resulting from such methods. This coating results in e.g., an increased sense of lubrication when in contact with water or an aqueous solution.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: April 14, 2020
    Assignees: Trustees of Boston University, Boston Medical Center Corporation
    Inventors: Mark W. Grinstaff, Stacy L. Chin, Ruiqing Xiao, Benjamin Goldman Cooper, Karen Buch, Ducksoo Kim
  • Stents having biodegradable layers
    Patent number: 10617795
    Abstract: A method for preparing a laminate coronary stent comprising: providing a stent framework; and depositing a plurality of layers on said stent framework to form said laminate coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: April 14, 2020
    Assignee: Micell Technologies, Inc.
    Inventors: James B. McClain, Charles Douglas Taylor, Robert Rabiner
  • Drug eluting medical implant
    Patent number: 10617796
    Abstract: Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 14, 2020
    Assignee: Lyra Therapeutics, Inc.
    Inventors: Maria Palasis, Changcheng You, Danny Concagh, Lee Core, Kicherl Ho, Upma Sharma, Gregory T. Zugates
  • Composite material for the X-ray contrast imaging of non-X-ray contrast implants
    Patent number: 10617797
    Abstract: The invention relates to the field of biotechnology and medicine, more precisely, to manufacturing technique of implantable medical devices (stents) containing organic lanthanum compound-based X-ray contrast agents distributed within the coating. The objective of this invention is the development of a biocompatible (and biodegradable) polymeric coating with glycolane on the surface of polymeric biodegradable vascular stents and other polymeric implants, which ensures, by means of introduction into a stent, satisfactory radiopacity both during stent installation in a patient and after installation, with a simultaneous additional positive effect provided by therapeutic properties of glycolane.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 14, 2020
    Assignee: LIMITED LIABILITY COMPANY “BIOSTEN”
    Inventors: Alla Nikolaevna Generalova, Anna Igorevna Prostyakova, Igor Ivanovich Pashkin, Vitaly Pavlovich Zubov, Dmitry Valeryevich Kapustin
  • Device for aspirating and transferring blood
    Patent number: 10617798
    Abstract: A device for aspirating and transferring blood during a surgical operation has a first chamber and a second chamber for collecting and transferring the aspirated blood, and an electronically controlled valve unit for connecting the chambers to a vacuum source. The valve unit establishes this connection alternately between the first chamber and the vacuum source and the second chamber and the vacuum source, such that the first or second chamber connected to the vacuum source can be filled with aspirated blood, and the other, second or first chamber can be emptied at the same time. The valve unit is connected to the first and second chamber and permits a pressure increase in the first or second chamber to be emptied. This device allows blood to be efficiently collected and transferred during operations in a way that is gentle on the blood.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: April 14, 2020
    Assignee: MEDELA HOLDING AG
    Inventors: Robin Mann, Martin Walti
  • Removable inlet manifold for a medical waste collection system
    Patent number: 10617799
    Abstract: A removable manifold for a medical/surgical waste collection system. The manifold is dimensioned to be mounted to a receiver integral with the system. The manifold includes at least one tube through which waste is drawn into a manifold cage. The tube extends through an inlet port into a void space internal to the manifold cage at an angle. The tube exits the manifold cage and centered along an axis that is off center to the longitudinal axis of the manifold cage where it engages a complementary valve internal to the receiver. The valve regulates flow between the receiver and the down line components of the waste collection system. The valve is normally closed. When the manifold is fitted to the receiver the tube engages the valve and rotation of the manifold moves the valve to the open position allowing fluid flow from the manifold and receiver to the downstream components of the system.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: April 14, 2020
    Assignee: Medline Industries, Inc.
    Inventors: Andrew Mills, David Noskowicz, Brian Barkeley, Zachary Zott, Stuart Mintz
  • Silencer for vacuum system of a wound drainage apparatus
    Patent number: 10617800
    Abstract: Apparatus (10, 200) for the provision of TNP therapy to a wound is described, the apparatus (10, 200) including: a waste canister (22, 204) into which fluid is aspirated from a wound by aspiration pump means (44, 248) and a fluid flow path (420, 422) for at least a part of said aspirated fluid on an outlet side of said aspiration pump means (44) wherein said fluid flow path (420, 422) on the outlet side comprises a silencing system (400) having a plurality of silencing elements (402, 404, 406) therein.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: April 14, 2020
    Assignee: Smith & Nephew PLC
    Inventors: Max Middleton, Stephen Jacob
  • Canister status determination
    Patent number: 10617801
    Abstract: A method and apparatus are disclosed for determining status of a canister of a topical negative pressure (TNP) system. The method includes the steps of monitoring pressure provided by a pump element of the TNP system, determining at least one characteristic associated with the monitored pressure and determining status of at least one parameter associated with a canister of the TNP system responsive to the determined characteristics.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: April 14, 2020
    Assignee: Smith & Nephew PLC
    Inventors: Edward Vernon-Harcourt, Jake Turner, Benjamin Gordon
  • Aspirators
    Patent number: 10617802
    Abstract: A valve assembly (50) comprising a three-way connector (51) operatively interconnecting: an inlet (58), an outlet (56) and a vent (66), the inlet (58) being operatively connectable, in use, to an aspirator tube; the outlet (56) being operatively connectable, in use, to a syringe (82); and the vent (66) comprising a one-way valve (70) permitting, in use, the flow of a fluid out of the three-way connector (51), wherein the inlet (58) comprises a receptacle (60) containing a porous or perforated element (62) which, when dry, permits the flow of gasses into the three-way connector (51), but which when wetted by a liquid, inhibits or prevents the flow of liquid into the three-way connector (51).
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: April 14, 2020
    Assignee: Aspirate N Go Ltd.
    Inventor: George Gallagher
  • Aspirating cautery forceps
    Patent number: 10617803
    Abstract: Multiple surgical devices that may be used during surgical procedures are shown and described herein. A surgical device includes an outer cannula and an inner member that has a pair of electrodes positioned at a distal end. The inner member defines an aspiration delivery channel with an opening. A handle assembly actuates the outer cannula relative to the inner member, thereby adjusting a size of the opening of the aspiration delivery channel. In another exemplary configuration, an irrigation hub is provided to deliver irrigation through the surgical device.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: April 14, 2020
    Assignee: Nico Corporation
    Inventors: Joseph L. Mark, Brian C. Dougherty
  • Integrated autotransfusion bowl and fluid line organizer
    Patent number: 10617804
    Abstract: An autotransfusion system for separating fluid constituents includes a centrifuge housing and a rotatable driving member mounted within the centrifuge housing. The rotatable driving member is configured to receive therein and rotationally engage any one of a plurality of centrifuge bowls with different heights. In some embodiments, the centrifuge bowl is integrated with a fluid line organizer to provide for easy and efficient organization of a plurality of different fluid lines incorporated into the autotransfusion system. In some embodiments, the centrifuge bowl and fluid line organizer are easily and efficiently coupled to the centrifuge housing for autotransfusion processing.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: April 14, 2020
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Andrea Galavotti, Elisa Maculan, Giampaolo Simonini, Ivo Panzani