Abstract: A nonwoven fabric includes fibers of a fiber raw material including gelatin, the fibers including at least one of an antimicrobially effective substance and an antibiotic, wherein the fibers are produced by rotational spinning.

Abstract: In various exemplary embodiments described herein, an absorbent structure (e.g., a paper material) having an applied absorbent material (e.g., an absorbent film) may be formed by treating a fiber (e.g., a cellulosic fiber) with an applied absorbent material forming system (also referred to as a “film forming system”), absorbent materials, compositions, methods of making absorbent materials, and the like.

Abstract: The present invention is directed to a unique technology for preparing a growth-factor free, cylindrical, hydrogel implant that has multiple (three or more) longitudinal hydrogel zones with varying chemical and physical properties. The implant may be wholly made of hydrogels or the hydrogels may be associated with cells, such as mesenchymal stem cells (MSCs).

Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

Abstract: The present invention relates to an implant (10) comprising: a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.5 to 1, and a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.

Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The method for producing a three-dimensional artificial tissue is a method in which a three-dimensional artificial tissue extending in a predetermined direction is produced. The method includes: preparing a device including a culture tank having a culturing space surrounded by sidewalls, and a flow channel-forming member that penetrates through the sidewalls that face each other and is suspended in the culturing space along a predetermined direction; culturing cells in the culturing space and thereby forming a three-dimensional artificial tissue through which the flow channel-forming member penetrates; and removing the flow channel-forming member from the three-dimensional artificial tissue and thereby forming a perfusion flow channel that penetrates through the three-dimensional artificial tissue.

Abstract: Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with Tenascin-C and/or fibrillin 2.

Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.

Abstract: A borate bioactive glass is described, and may be used in the form of particles in an acidic mixture to form a borate bioactive glass paste. The borate bioactive glass paste may be used for the restoration of dentin and enamel on a tooth surface by the precipitation of calcium phosphate. The borate bioactive glass may also be used as a bone grafting material.

Abstract: Disclosed are novel compositions and methods for making a polymer substrate and a ligand that includes a proximal portion with a photoactive compound bound to the polymer substrate, a terminal portion with an anti-infective/anti-microbial compound, and a reactive portion attaching the proximal portion and the terminal portion.

Abstract: A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract: A medical device including a plasma-treated porous substrate that is functionalized to provide a hydrophilic surface, and a process for preparing such a medical device, are disclosed. The method includes plasma treating at least a portion of a surface of a porous substrate with a gas species selected from oxygen, nitrogen, argon, and combination thereof. The gas species is configured to functionalize the surface of the medical device and form a hydrophilic surface.

Abstract: A drainage device (1) particularly for aspiration in case of therapies with aspiration, fistulas, dehiscences of surgical wounds, bedsores, traumas and similar lesions, comprising an aspiration pouch (2) which is supported by a sheet-like element (5) which can be associated with the lesion (10) and is connected to aspiration means (3) by way of a connecting element (4).

Abstract: The invention relates to a method for estimating a negative pressure at a wound site during a negative pressure wound therapy. The method comprises the steps of determining a negative pressure value by means of a pressure sensor, determining a pump speed associated with the electrical pump, multiplying the pump speed by a constant to obtain a modification value, and combining said modification value with the negative pressure value determined by means of the pressure sensor to obtain a modified negative pressure value. Said modified negative pressure value corresponds to the estimated negative pressure present at the wound site. The invention further relates to a negative pressure wound therapy system adapted to execute said method of estimating a negative pressure at a wound site.

Abstract: A chest wound seal for treating traumatic pneumothorax following a penetrating chest wound. The chest wound seal comprises a wound pad with an absorbent bottom surface and a nonporous top surface embedded with unidirectional valves that allow evacuation of air and fluid from the pleural cavity but prevents re-entry of air into the thorax. A central vacuum column mounted over at least one unidirectional valve. The chest wound seal further comprises a plurality of wound pad segments radiating from the central vacuum column, wherein each segment comprises at least one manual valve configured to create a separate sealed area against the skin surface to suit body types with different size and morphological features. The central vacuum column is adapted to be connected to a vacuum pump which enables evacuation of harmful air and fluid from the pleural cavity thereby reducing the shock induced by hypoxia and increasing patient survivability.

Abstract: Dressings, systems, and methods are disclosed that, in some embodiments, relate to treating a tissue site. In one embodiment, a dressing may include a manifold, a retention pouch, a sealing member, and a conduit interface. The manifold may be adapted to distribute reduced pressure to the tissue site, and the retention pouch may be adapted to retain and manage fluid extracted from the tissue site. The sealing member may cover the retention pouch and the manifold to provide a sealed space with the tissue site. The conduit interface may be in fluid communication with the sealed space and an exterior surface of the sealing member. The dressing may be utilized with a therapy device operable to control reduced pressure in the dressing and fluid flow over the sealing member.

Abstract: A method for filling containers with fresh blood components, comprising the following steps of: a) providing a piece of equipment (1) defining a transit channel (3) having at least a first gap (3a) associated with a bag (5) or the like containing a fresh blood component, at least a second gap (3b) connected to a plurality of containers (6) to be filled, and at least a third gap (3c) connected to pumping means (12); b) isolating the first gap (3a) from the second gap (3b) and placing the latter in communication with the third gap (3c); c) suctioning the air contained in the containers (6) to be filled by means of the pumping means (12) so as to define a vacuum inside them; d) placing the first gap (3a) in communication with the second gap (3b), the containers (6) suctioning the contents of the bag (5) by effect of the vacuum defined inside them; and where the channel (3) has at least a fourth gap (3d) associated with an empty syringe (4) or the like, and by the fact that it comprises, after step d), the fol

Abstract: A lactation system is disclosed. Embodiments include at least one extraction mechanism including a compression mechanism and a collection mechanism, and a controller. The compression mechanism can include a plurality of manipulable members, each operably coupled to an actuator and arrangeable circumferentially about a breast of a user such that each member can be actuated to selectively apply pressure to a region of the breast. The collection mechanism can be removably coupleable to the compression mechanism and can comprise a storage compartment to receive and store milk The controller can be operably coupleable to the actuators to cause the members to move according to a movement pattern which can be configured to stimulate the breast to induce the flow of milk from the breast and modulated based on sensor feedback. A wearable garment with an inner structure can be removably coupled to the extraction mechanism. An outer cover can be arrangeable to conceal the extraction mechanism.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: The present invention relates to a method for contactlessly establishing a coupling between a medical apparatus (e.g., a hemodialysis apparatus or a peritoneal dialysis apparatus) and a remote control apparatus. An optical coupling signal is exchanged between the involved communication entities, in order to establish bijective, data-processing coupling between the remote control apparatus and the medical apparatus. Only after successful coupling is a remote control procedure initiated for remote control of the medical apparatus.

Abstract: A blood purification apparatus and a blood purification system that is operable with increased ease even if a blood purifier requires special treatment conditions and operational settings is used. A blood purification apparatus includes a blood purifier for giving blood purification treatment by purifying blood of a patient; and a control device that executes, in accordance with preset treatment conditions and/or operational settings, an operation for performing the blood purification treatment or an operation associated with the blood purification treatment.

Abstract: A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialyzer, and a dialysate flow path and a blood flow path which flow in opposing directions through the dialyzer. The disposable cartridge includes pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. In addition, the disposable cartridge possesses pump actuators (but not pump motors) for pumping dialysate and blood through their respective flow paths. Preferably, the disposable cartridge includes a filter for removing waste products from dialysate.

Abstract: An airtrap for a medical or physiological fluid in one embodiment includes a conical housing having a radius that increases from its top to its bottom when the housing is positioned for operation; a medical or physiological fluid inlet located at an upper portion of the conical housing; a medical or physiological fluid outlet located at a lower portion of the conical housing, the inlet and the outlet positioned and arranged so that medical or physiological fluid spirals in an increasing arc around an inside of the conical housing downwardly from the inlet to the outlet; and a gas collection area located at an upper portion of the conical housing. In another embodiment, the airtrap is shaped like a seahorse having a head section and a tail section. Any of the airtraps herein may be used for example in blood sets, peritoneal dialysis cassette tubing, and drug delivery sets.

Abstract: A housing for a dialysis machine, with a wall, an opening which is provided in the wall, and a door by means of which the opening can be closed. The door or an additional wall has an installation space for a device component, which can be closed by means of an additional door.

Abstract: Embodiments of the disclosure provide a method for evaluating dialyzers used in different medical applications (e.g., hemodialysis). Red blood cell volume lost in a dialyzer is monitored by obtaining blood flowrate measurements and hematocrit measurements at input ports and output ports of the dialyzer. The flowrate and hematocrit measurements are used to determine an accumulation of red cell blood volume in the dialyzer. The measurements may be obtained in a lab environment with an in-vitro blood source or may be obtained in a clinical setting with an in-vivo blood source from a patient.

Abstract: An air separator of an extracorporeal blood treatment machine is disclosed in which a flow conducting element is arranged directly downstream of a fluid inlet of an air separator opening into an air separating chamber, the fluid inlet forcing the inflowing fluid into a flow direction at least along/tangential to the chamber periphery.

Abstract: A monitoring device is operated to detect a disruption of a fluid connection between two fluid containing systems. A disruption detector in the monitoring device operates on a measurement signal (Pi) to detect an apparent disruption of the fluid connection and generate a corresponding alarm indication. The monitoring device is configured to optimize the configuration of the disruption detector to limit the number of false alarms, by operating a false alarm analyzer to produce a count (FA #) of false alarm indications generated per unit time by the disruption detector for one or more configurations (?L) of the disruption detector, and by operating an updater to update the configuration (?L) of the disruption detector based on the count (FA #). The monitoring device may be connected to or part of an apparatus for blood treatment and operable to detect a disconnection of an extracorporeal blood circuit from a vascular system of a patient, e.g. a venous-side disconnection.

Abstract: An extracorporeal blood treatment apparatus (1) comprising a control unit (10) connectable to a blood warming device (200) and configured to issue a control signal for the blood warming device, wherein the control signal comprises a command directed to impose to the blood warming device (200) a modality of operation depending upon an identified mode of current operation of the blood treatment apparatus. A method for controlling the blood treatment apparatus (1) and an assembly including the blood treatment apparatus (1) and the blood warming device (200) are also disclosed.

Abstract: Data is received that characterizes infusions administered to a patient among each of a plurality of infusion channels. Thereafter, a plurality of infusion events and respective event times are identified based on the received data. A temporal view of the infusion events can then be displayed in a graphical user interface and/or the temporal view of the infusion events can form part of a report. The temporal view segregates each channel into a separate swim lane with each swim lane visualizing infusion events for the corresponding channel at the respective event times. Related apparatus, systems, techniques and articles are also described.

Abstract: An infusion device (1)comprises a housing (10)having a front side (102)and a back side (103)opposite to the front side (102). A display device (11)is arranged at the front side (102)of the housing (10). A pump mechanism (18)serves to act onto a disposable pump module (17, 4), the pump mechanism (18)being included in the housing (10). Herein, the housing (10)is constituted to receive the disposable pump module (17, 4)at the back side (103). In this way an infusion device is provided which allows placing a disposable pump module on the housing of the infusion device and which may offer space savings over existing infusion devices.

Abstract: Apparatus, systems and methods for the wireless communication of medical devices in an on-body fluid delivery system are disclosed. A system for on-body fluid delivery includes a primary patch pump adapted to attach a first infusion cannula to a user and to perform a plurality of primary patch pump functions, and a secondary patch pump adapted to attach a second infusion cannula to a user. The secondary patch pump is further adapted to perform a plurality of secondary patch pump functions substantially similar to the plurality of primary patch pump functions if an error condition associated with the primary patch pump is determined.

Abstract: An insertion mechanism (200) for a drug pump (10, 1300) includes an insertion mechanism (200) housing (202, 1202, 2202, 3202); a sleeve (220, 1220, 2220, 3220); a rotational biasing member (210, 1210, 2210, 3210) initially held in an energized state; a retraction biasing member (216, 1216, 2216, 3216) and a hub (212, 1212, 2212, 3212) connected to a proximal end of a needle (214, 1214, 2214, 3214), wherein the retraction biasing member (216, 1216, 2216, 3216) is held initially in an energized state between the hub (212, 1212, 2212, 3212) and the sleeve (220, 1220, 2220, 3220). The needle (214, 1214, 2214, 3214) is inserted into a target tissue by the rotational biasing member (210, 1210, 2210, 3210) and interaction between the hub (212, 1212, 2212, 3212) and housing (202, 1202, 2202, 3202). Retraction of the needle (214, 1214, 2214, 3214) is caused by decompressing or de-energizing of the retraction biasing member (216, 1216, 2216, 3216).

Abstract: A filling aid is provided for filling a cylinder ampule (7) with a medical or pharmaceutical fluid. The filling aid in a common housing (4) includes a first receiver (24) which is configured for receiving the cylinder ampule (7) to be filled, and a second receiver (26) which is configured for receiving a receptacle (18) containing a medical or pharmaceutical substance. A first access opening (28) is formed on the first receiver (24) and is arranged such that the first access opening (28) lies opposite an opening of a cylinder ampule (7) when this cylinder ampule is inserted into the first receiver (24). A second access opening (30) is formed on the second receiver (26) and is arranged such that the second access opening (30) lies opposite an opening of a receptacle (18) when this receptacle (18) is inserted into the second receiver (26).

Abstract: An injection guide globally aligns an injector to an angle selected for consistent subcutaneous delivery of an injectate, while locally aligning a patient's skin normal to the injection path at the location where the injection pierces the skin. This arrangement advantageously maintains controlled contact between an injector and a subject's skin in order to deliver the full, intended volume of injectate into the patient's subcutaneous layer while avoiding misdelivery into adjacent layers such as the patient's dermis or muscle.

Abstract: An apparatus for transdermal injection includes a collet configured to transition between first and second states. In the first state, the collet receives a cartridge with a predetermined elongate shape. In the second state, an inner surface of the collet substantially conforms to the predetermined elongate shape of the cartridge such that expansion of the cartridge, when the cartridge is pressurized, is substantially uniformly opposed.

Abstract: A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and circuitry configured to process signals provided by the sensing arrangement. The sensing arrangement is configured such that, when the sensor device is attached to the drug delivery device, the sensing arrangement is operable to read encoded information present on a rotatable component internal to the drug delivery device and that is able to be sensed through a window or aperture of the drug delivery device, and is operable to sense through the window or aperture at least a part of a drive mechanism of the drug delivery device. The circuitry is configured to determine information relating to a set dose, and to determine information relating to whether the drug delivery device is in a dose setting mode or whether the device is in a dose delivery mode.

Abstract: An auto-injector device including a syringe, a needle arranged in the vicinity of a first end of the syringe, and a plunger arranged within the syringe. A volume within the syringe between the plunger the needle accommodates medicine, such that movement of the plunger toward the needle dispenses medicine through the needle. A selection assembly configurable by a user to adjust an amount of medicine dispensed by the auto-injector device and depth to which the medicine is delivered. Also, a method for treating a skin lesion or skin disorder utilizing the auto-injector and a kit for patient administered treatment.

Abstract: The present disclosure relates to a magnifying device attachable to an injection device. The magnifying device includes a frame having a distal end and having a proximal end opposite to the distal end and further has a receptacle extending from the distal end towards the proximal end. The receptacle is accessible from the distal end to receive a proximal end section of the injection device therein. A magnifying lens is fixed to the proximal end of the frame and extending at least partially across the proximal end of the frame.

Abstract: A prefilled syringe includes a syringe barrel including: a liquid drug discharge portion on a distal end of the barrel, and an opening on a proximal end of the barrel; a cap; a gasket located in the syringe barrel; a plunger including: a shaft portion inserted in the syringe barrel from the opening, and a pressing portion located on a proximal end of the shaft portion and configured to be manually pushed by a user, the plunger being movable toward a distal direction by pushing the pressing portion to slide the gasket toward the liquid drug discharge portion; a liquid drug; an upraised portion located on an inner wall of the syringe barrel between the gasket and the opening; and a clicker.

Abstract: An injection device for holding and actuating a pre-filled syringe including a barrel holder having an axial passageway adapted to hold the barrel of the pre-filled syringe, a grip movable relative to the barrel holder to move a plunger of the pre-filled syringe, the grip configured to be locked to the barrel holder to prevent axial movement therebetween and unlocked from the barrel holder to permit axial movement therebetween, and a needle guard arranged to retract into the barrel holder in response to force against an injection site to unlock the grip from the barrel holder.

Abstract: There is provided a method involving a portable medical device (1), being carried by a user and a mobile phone (2) carried by the same user, the method comprising the steps of a) the mobile phone (2) at a time point (first time point) determining a geographical position of the mobile phone (2), and providing the geographical position and the first time point to a server (4) via a data connection, or the mobile phone (2) having its position determined by the cell network (3), and the cell network (3) providing the position and the first time point to the server (4), then b) the server (4) using the position and the time point to retrieve position-specific data for the time point, then c) the server (4) using a the data from step b. to determine whether the medical device should be serviced or replaced. There is also provided a system, a server and a mobile phone.

Abstract: A safety syringe comprising a needle redirection device that is desirably configured to bend the needle shaft forwardly of the barrel following an injection to thereby redirect the needle tip from a first position where it projects forwardly in coaxial alignment with the syringe barrel to a second position where the needle tip is covered or protected from incidental or accidental contact and associated needle sticks. Both sliding and pivoting embodiments are disclosed.

Abstract: A needle system for penetrating to or passing thought an object or an organ comprising a semiconductor die, one or more needles, wherein the needles move relative to the die using one or more actuators. The actuators are controlled by a controller wherein the controller instruct the needle to penetrate into or to pass through and/or retract from the object or organ. The needle system is used among other treatments for drug delivery, blood extraction, blood analysis, glucose measurements, blood measurements, nerve system stimulus treatment, hair removal, skin lesions coloring or removal or tattoo painting or removal.

Abstract: The present disclosure describes a syringe assembly including a syringe and a tamper evident cap disposed over a Luer connection of the syringe, the tamper evident cap having a main body that defines a proximal end defining an opening, a distal end opposite the proximal end along the axial direction, an outer surface, and an inner surface opposite the outer surface that defines a passage to receive a tip cap and the Luer connection, where the tamper evident cap is spaced from the tip cap. The main body further defines a frangible connection between the proximal and distal ends of the main body. The frangible connection can break under a force applied to the distal end of the tamper evident cap such that the proximal end of the tamper evident cap remains engaged with the syringe when the frangible connection breaks.

Abstract: An ultrasonic topical applicator and method is provided for dispensing a topical including an adjustable head including a mesh nebulizer having a perforated plate with a plurality of pores and a vibrating actuator, a cartridge having a reservoir for holding a topical and a port configured to secure the reservoir to the mesh nebulizer, and a handle including a power source and a controller configured to control energy from the power source to the mesh nebulizer based on an energy profile, where the vibrating actuator is configured to produce ultrasonic vibration based on the energy profile, and where the adjustable head is configured to lock into within the handle and to allow the adjustable head to rotate.

Abstract: The present inventions are directed to spray tips for multidirectional or three-dimensional spraying of an unmixed two-part sealant and/or hemostat comprising a first biocompatible component and a biocompatible second component onto a tissue or wound comprising: a hollow body having inside a first component distribution compartment and a second component distribution compartment, said compartments not in fluid communication with each other. The first component can contain one or more biologic components, preferably fibrinogen and the second component can contain one or more biologic component different from the first biologic component, preferably thrombin and/or thrombin precursors. The present inventions are also directed to methods of spraying the unmixed two-part sealant or hemostat using the spray tip and associated components described above by simultaneously expressing the first component and the second component from the syringes.

Abstract: Drug supply units are disclosed which comprise substrates having a plurality of holes formed therein.

Abstract: A blister packaging for a pharmaceutical cartridge or capsule and methods of forming same are disclosed.