Patents Issued in May 12, 2020
  • Patent number: 10646617
    Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: May 12, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R. Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
  • Patent number: 10646618
    Abstract: The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic bone replacement for a patient in need thereof. The bone graft is made of a scaffold or matrix of sheet material having a 3-dimensional pattern of a continuous network of voids and/or indentations for enhancing new bone growth.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: May 12, 2020
    Inventor: Timothy Ganey
  • Patent number: 10646619
    Abstract: A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, which material shows an increased capacity to induce bone formation, and a process of preparation thereof.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 12, 2020
    Assignee: GEISTLICH PHARMA AG
    Inventors: Claudio Zihlmann, Michael Bufler
  • Patent number: 10646620
    Abstract: A copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, such as a catheter balloon, with improved bursting strength, in which said copolymer has the following characteristics: number-average molecular mass of the PE blocks greater than 500 g/mol, and number-average molecular mass of the PA blocks greater than 10 000 g/mol.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: May 12, 2020
    Assignee: ARKEMA FRANCE
    Inventors: René-Paul Eustache, Frédéric Malet, Eric Gamache, Alejandra Reyna-Valencia, Damien Rauline
  • Patent number: 10646621
    Abstract: An apparatus is disclosed for a biofunctional molecular imprint apparatus comprising a supportive structure that cuts, punctures, retains, repairs, protects, interrogates, and/or supports the function of a body tissue or other substance; a surface material that receives and retains a molecular imprint and that is positioned to contact the body tissue or other substance during use; and a molecular imprint of a bioactive molecule that influences blood coagulation, tissue damage, pain, immune response, inflammation, infection, healing, tissue regeneration, cell adhesion, the formation of extracellular matrix, tumorigenesis, angiogenesis, bacterial growth, and/or side effects.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 12, 2020
    Assignee: Utah Valley University Foundation, Inc.
    Inventors: Timothy Edwin Doyle, Natalie Charlotte Sullivan
  • Patent number: 10646622
    Abstract: This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 ?m thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: May 12, 2020
    Inventors: Gerhard Schmidmaier, Michael Raschke, Axel Stemberger
  • Patent number: 10646623
    Abstract: An implantable medical device, which comprises a device substrate, a coating on the substrate which includes a drug, and a protective layer which overlies the coating. The protective layer comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid and a lactic acid/glycolic acid copolymer having a weight average molecular weight of not more than 40,000.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 12, 2020
    Assignee: DePuy International Limited
    Inventors: Yufu Li, Deborah Schachter, Raymond S. Shissias, Sandra Wechsler
  • Patent number: 10646624
    Abstract: Apparatus and a method for the provision of topical negative pressure therapy to a wound site are described, the apparatus comprising: vacuum generating means for generating a negative pressure at said wound site said vacuum generating means being operably connected to a dressing at said wound site by aspiration conduit means; pressure sensing conduit means in fluid communication with said aspiration conduit means at a junction adjacent said dressing; first pressure sensing means between said junction and said vacuum generating means; second pressure sensing means operably associated with said pressure sensing conduit means; diagnostic means in communication with said first and second pressure sensing means; and control means in communication with said diagnostic means for controlling pressure in said aspiration and said pressure sensing conduit means.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 12, 2020
    Assignee: Smith & Nephew PLC
    Inventor: Edward Hartwell
  • Patent number: 10646625
    Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible member having a distal end portion arranged for anchoring the instrument in the patient's stomach and for enabling fluids to be removed from the patient's stomach. Suction is applied to the patient's stomach by the distal end portion of the instrument to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the instrument to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: May 12, 2020
    Assignee: Boehringer Laboratories, Inc.
    Inventors: Christopher L. Radl, Trevor Smith, Helmut Laenger
  • Patent number: 10646626
    Abstract: A reduced-pressure device includes a housing having recesses on sidewalls thereof, an air pressure storage unit and a compression unit. The air pressure storage unit is installed in the housing and comprises a pressure storage container, a piston assembly and a piston spring, and the compression unit is mounted on the piston assembly. The compression unit further includes a pressing element and a turntable. The pressing element is accommodatable in the recesses of the housing, and rotatable by the turntable in relative to the air pressure storage unit and the housing, and when the pressing element is pulled out of the recesses and rotated to a predetermined position to compress the piston assembly to produce a negative pressure in the pressure storage container, the pressing element can be rotated back to the original position to be accommodated in the recesses again after using.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 12, 2020
    Assignee: BenQ Materials Corporation
    Inventor: Mao-Sung Huang
  • Patent number: 10646627
    Abstract: An anti-clog suction tip apparatus includes a suction tip having a suction opening and an interior defining a suction channel. An ejection wire channel extends to a wire exit opening into the suction channel that is located proximate the suction opening. An ejection wire including a ball tip at an end thereof occupies the ejection wire channel and is transitionable between a retracted configuration and an advanced configuration such that, in the retracted configuration, the ejection wire including the ball tip is retained within the ejection wire channel and does not obstruct suctioning of debris through the suction channel; and in the advanced configuration, the ball tip of the ejection wire does not extend more than three millimeters beyond the suction opening.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: May 12, 2020
    Inventors: Robert Sean Hensler, Thomas Eric Melin
  • Patent number: 10646628
    Abstract: Various forms of anti-clog suction tips apparatus are disclosed. An exemplary anti-clog suction tip apparatus includes a suction tip assembly having a suction tip with a suction opening at a first end thereof for removing debris through suction, a hose attachment portion for attaching the suction tip assembly to a suction source, and an ejection wire channel. The apparatus further includes an ejection wire assembly having an ejection wire extending within the channel and an ejection button integral with or connected to the ejection wire. Applying a force to the ejection button advances the ejection wire through the channel such that an end portion of the ejection wire enters the suction tip and dislodges debris clogging the suction tip. The ejection wire may include an enlarged end portion such as, for example a ball tip. One or more of the components of the apparatus may be single-use and disposable.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: May 12, 2020
    Inventors: Robert Sean Hensler, Thomas James Philpott, Daniel Lee Bizzell, Michael Starkey, Raeshon Lamont McNeil, Juan Carlos Perez, Thomas Eric Melin, Kenneth D. Ballard
  • Patent number: 10646629
    Abstract: A pleural manometry catheter comprises two tubes and a pressure transducer. The first tube provides a first flow path from the pleural cavity to the pressure transducer. The second tube provides a second flow path from the pleural cavity such that fluid can be drained from the pleural cavity. The pressure transducer comprises a processor for processing, continuously, the real-time fluctuations in the pressure of the second flow path and therefore the pleural cavity as fluid is aspirated from it via the first tube.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: May 12, 2020
    Assignee: Rocket Medical PLC
    Inventors: Edwin Richard Roe, Richard Martin Varey
  • Patent number: 10646630
    Abstract: Blood pump devices having improved rotor design are provided herein. Such blood pump devices include rotors having cantilevered support through a sealed mechanical bearing disposed outside a blood flow path of the device so as to avoid thrombus formation caused by blood contact with the bearing. The bearing means can be rotatably coupled with a proximal portion of the rotor shaft extending outside the fluid path, while a stator drives rotation of the rotor shaft so that one or more rotor blades on a distal portion of the rotor force blood flow through the device. The bearing means may include one or more radial bearings on a proximal portion of the rotor shaft that are isolated from the blood flow path by one or more rotary seals.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: May 12, 2020
    Assignee: TC1 LLC
    Inventor: William V. Hodges
  • Patent number: 10646631
    Abstract: An apparatus for treating a medical fluid is provided which includes a treatment machine having a coupling surface, with a cassette made of a hard part having liquid-conducting passages which are covered by a flexible film being able to be coupled to the coupling surface of the treatment machine. A corresponding medical cassette is also provided. An air-free coupling of the flexible film of the cassette to the treatment machine is ensured in that air can be sucked out areally along a plane between the flexible film and the coupling surface during the coupling process and/or with a coupled cassette. A method for coupling the cassette and a method for checking the leaktightness of the cassette via the vacuum control of the air suction is also provided.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: May 12, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Götz Günther, Jürgen Häcker, Markus Köhler, Martin Lauer, Ralf Müller, Hans-Peter Schneider, Tobias Weber, Manfred Weis
  • Patent number: 10646632
    Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: May 12, 2020
    Assignee: GAMBRO LUNDIA AB
    Inventors: Paolo Rovatti, Alessandro Surace, Carlo Alberto Lodi, Anders Wallenborg, Anders Nilsson, Kristian Solem, Jan Sternby, Thomas Hertz
  • Patent number: 10646633
    Abstract: A heating device for one or more components of an extracorporeal circuit of a blood treatment device, in particular a dialyzer, an adsorber, or a filter, includes at least one reception region for the component, and at least one heating element for heating the component located in the receiver. The heating device has a plurality of layers, with at least one layer being a flexible layer or an elastically deformable layer.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: May 12, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Arne Peters, Goekhan Oerter
  • Patent number: 10646634
    Abstract: An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine comprising a pumping mechanism and a peritoneal dialysis fluid heater. The example peritoneal dialysis system also includes a disposable set comprising a disposable cassette operable with the pumping mechanism and a heater bag operable with the heater. The example peritoneal dialysis system additionally includes a conductivity sensor positioned and arranged to provide feedback to the APD machine. The example APD machine is configured to mix a peritoneal dialysis fluid for treatment in the heater bag using a plurality of peritoneal dialysis constituent fluids. In addition, the example APD machine is configured to use feedback from the conductivity sensor to evaluate the mixed peritoneal dialysis fluid for treatment.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: May 12, 2020
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Alex Anping Yu, James Grayson, Robert W. Childers
  • Patent number: 10646635
    Abstract: The present disclosure concerns a method for preparing an extracorporeal blood circuit for its use in a blood treatment of a patient, which treatment is carried out using a blood treatment apparatus and using a blood treatment device, which comprises a blood chamber and a dialysate chamber partitioned off therefrom by a membrane, The method comprising: filling the extracorporeal blood circuit using a priming solution, wherein the priming solution comprises citrate, or filling of the extracorporeal blood circuit using a priming solution and using a citrate solution. The invention further comprises devices suitable for carrying out the method.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: May 12, 2020
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Robert Pohlmeier, Wofgang Wehmeyer
  • Patent number: 10646636
    Abstract: A needle dislodgement and blood leakage detection device includes a sensor assembly having a flexible sensor and a flexible substrate. The flexible sensor is provided, on an underside thereof at a location close to the flexible substrate, with a photoelectric sensor including near infrared transmitters that are of an array arrangement. The photoelectric sensor includes a signal amplifier module and a signal filter module that are electrically connected. An alarm device is coupled to the sensor assembly and includes a microprocessor unit, which includes a digital signal converter module, a signal sampling module, a signal demodulation module, a signal processing module, a time division module, a storage module, and a wireless transmission module that are connected in series. The digital signal converter module is connected to the signal filter module. The storage module and the wireless transmission module are respectively connected to a display unit and a computer.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: May 12, 2020
    Assignee: SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yi-Chun Du, Bee Yen Lim, Ming-Jui Wu
  • Patent number: 10646637
    Abstract: A cardioplegic agent delivery system comprises a syringe pump for providing cardioplegic agent into a carrier fluid of a perfusion system, a flow sensor for sensing a flow of the carrier fluid, and an interlock responsive to the flow sensor. The interlock prevents operation of the syringe pump in the absence of carrier fluid flow sensed by the flow sensor. This provides increased safety in a cardioplegic agent delivery system.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 12, 2020
    Assignee: Spectrum Medical Ltd.
    Inventor: Stephen Turner
  • Patent number: 10646638
    Abstract: The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: May 12, 2020
    Inventor: Gary L. McNeil
  • Patent number: 10646639
    Abstract: A valved container assembly has a container for containing a fluid, extending in an axial direction, and having an open front end and a valve disposed in the container. A plunger element is disposed axially rearward of the valve and is axially moveable in the container. The plunger element is configured to increase the pressure of a fluid in a first volume of the container upon axial movement of the plunger element relative to the valve. The valve includes a channel bypassing a seal, the channel having a first opening in fluid communication with the atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable from a sealing configuration to an open configuration upon the pressure of the fluid in the first volume exceeding a first pressure threshold.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: May 12, 2020
    Assignee: Consort Medical PLC
    Inventors: Ian Anderson, Matt Ekman
  • Patent number: 10646640
    Abstract: The package for a pharmaceutical product includes a syringe and an electronic tag for obtaining information relating to the integrity of the product as assessed from an exposure of said product to physical or environmental conditions during a time span. The tag is attached at or to a constituent of the syringe; or at least a portion of the tag is integrated in a constituent of the syringe. The tag includes an electronics unit having a control unit, a sensor unit having at least one sensor for monitoring the physical or environmental conditions, a display unit having a display for displaying data relating to the integrity referred to as status data and a switch. The control unit is structured and configured for effecting that the display unit displays the status data in reaction to an operation of the switch.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: May 12, 2020
    Assignee: BERLINGER & CO. AG
    Inventor: Corneliu Tobescu
  • Patent number: 10646641
    Abstract: A liquid dispensing pump includes a lead screw having a lead screw shaft extending along a lead screw axis, and the lead screwing is operably connected to a piston connected to a liquid reservoir. A thrust bearing is connected to the lead screw and configured to support an axial force on the lead screw when dispensing liquid. A magnet is engaged to the thrust bearing so as to move in response to the axial force on the lead screw. A magnetic transducer is mounted in proximity to the magnet and configured to generate an output signal in responsive to the magnet move.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: May 12, 2020
    Assignee: Micromo Electronics, Inc.
    Inventors: Robert Gloeckner, Isaac Diggs
  • Patent number: 10646642
    Abstract: A medicinal device includes a first member; and a second member configured to be attachable to and detachable from the first member, the second member being a part of a medicinal-liquid administering device and including: a first member comprising a first-member-side power transmission part, and a second member comprising a second-member-side power transmission part; wherein the first-member-side power transmission part and the second-member-side power transmission part are configured to be engaged with each other for administering medicinal liquid into a living body; and wherein the second member is configured to open a housing covering the first-member-side power transmission part to engage the second-member-side power transmission part with the first-member-side power transmission part at a time of attaching the first member to the second member.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: May 12, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Akira Kondo, Joji Uchiyama, Hideyuki Sato
  • Patent number: 10646643
    Abstract: A system and method are provided for preventing a sharp stick hazard from a needle tip of an automatic injector device. In some embodiments, a skin contact surface of the device is attached to an injection site, for example by an adhesive. Optionally a locking mechanism holds a needle extended into an injection site. A body of the device is optionally movably attached to the skin contact surface. Pulling the body away from the injection site optionally moves the body with respect to the skin contact surface. Movement of the body with respect to the skin contact surface optionally moves interlinked parts of the locking mechanism, releasing the locking mechanism.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 12, 2020
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Ran Hezkiahu, Tal Hammer
  • Patent number: 10646644
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: May 12, 2020
    Assignee: CalXStars Business Accelerator, Inc.
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Patent number: 10646645
    Abstract: The present invention relates to a medical injection device for preventing a target substance contained in an injection solution from being lost when the target substance is not settled or floated, and for evenly agitating the injection solution to be safely injected. A medical injection device according to the present invention includes a container having an agitation means and a vibration sensing ball, an injection solution filter, an injection solution level controller, a bellows connector, and a guide tube.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: May 12, 2020
    Assignee: DONGKOO BIO & PHARMA CO., LTD.
    Inventor: Jun-Woo Kim
  • Patent number: 10646646
    Abstract: Implantable infusion apparatus, systems and methods that involve the use of a sensor that is associated with the catheter outlet.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 12, 2020
    Assignee: The Alfred E. Mann Found. For Scientific Research
    Inventors: Lawrence Scott Ring, Peter C. Lord, Scott R. Gibson, Sam W. Bowman, Brian M. Shelton
  • Patent number: 10646647
    Abstract: An adjusting device for adjusting the flow rate of a medicinal fluid-conveying system, said device having a selection wheel for selecting one of a number of possible flow rates, having an adjusting disc connected to said selection wheel for adjusting the selected flow rate, and having a catching nose that cooperates with the outer edge of the adjusting disc, is improved in that the adjusting disc has a star shape.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: May 12, 2020
    Assignee: B. Braun Melsungen AG
    Inventor: Karsten Haslbeck
  • Patent number: 10646648
    Abstract: An intravenous delivery system may operate by gravity feed, and may have a liquid source containing a liquid, a drip unit that receives the liquid from the liquid source, and tubing that receives the liquid from the drip unit for delivery to a patient. A flow rate sensor may be used to measure a flow rate of liquid through the intravenous delivery system, and may generate a flow rate signal indicative of the flow rate. A controller may receive the signal, and may compare the flow rate with a desired flow rate. If the flow rate is more or less than the desired flow rate, the controller may transmit a control signal to a flow rate regulator. The flow rate regulator may receive the control signal and, in response, modify the flow rate to bring the flow rate closer to the desired flow rate.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: May 12, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: S. Ray Isaacson, Weston F. Harding, Ralph L. Sonderegger, Austin Jason McKinnon, Milan Ivosevic
  • Patent number: 10646649
    Abstract: Medical devices and methods and apparatuses for identifying fluids in a conduit of a device are provided. An exemplary apparatus for identifying an infusate in a conduit of an infusion device includes a transmitter element for transmitting a beam of energy for interaction with the infusate. Further, the apparatus includes a receiver element for receiving a signal from the beam of energy after interaction with the infusate. Also, the apparatus includes an identifier element coupled to the receiver element for analyzing the signal to identify the infusate. The transmitter element and receiver element may form a spectroscopy device and may transmit and receive a beam of infrared light or near infrared light.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: May 12, 2020
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Guangping Zhang, Sarnath Chattaraj, Anuradha Biswas Bhatia, Maria C. LoVerme, Afshin Bazargan
  • Patent number: 10646650
    Abstract: Methods and modules for using physiological (biometric) variables to advance the state of the artificial pancreas. The method and system includes one or more modules for recursive model identification, hypoglycemia early alert and alarm, adaptive control, hyperglycemia early alert and alarm, plasma insulin concentration estimation, assessment of physical activity (e.g., presence, type, duration, expected effects on insulin sensitivity and GC), detection of acute stress and assessment of its impact on insulin sensitivity, detection of sleep and its stages and assessment of sleep stages on GC, sensor fault detection and diagnosis, software and controller performance evaluation and adjustment and/or pump fault detection and diagnosis.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: May 12, 2020
    Assignee: ILLINOIS INSTITUTE OF TECHNOLOGY
    Inventors: Ali Cinar, Kamuran Turksoy, Iman Hajizadeh
  • Patent number: 10646651
    Abstract: A system and method for monitoring and delivering medication to a patient. The system includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule based application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. A system monitor is also in communication with the controller to monitor system, remote system, and network activity and conditions. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: May 12, 2020
    Assignee: ICU Medical, Inc.
    Inventors: William Kenneth Day, Timothy L. Ruchti
  • Patent number: 10646652
    Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and one or more controllable elements. The drug delivery system may further include one or more sensors coupled to the drug delivery device, and a controller coupled to the one or more sensors and the one or more controllable elements. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device. Furthermore, the controller may be configured to control the controllable element based on the condition or the operational state of the drug delivery device and/or identity information stored in a memory onboard the device. A method for use with a drug delivery device is also disclosed.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: May 12, 2020
    Assignee: AMGEN INC.
    Inventors: Adam B. McCullough, Ferry Tamtoro, Huaying Yang, Mark Ka Lai Lee, Desheng Yin, Scott R. Gibson, Donald Busby, Peter V. Shultz, Keith P. Kogler, Basel Hasan Taha, Jimmie L. Ward, Christopher R. Folk, Steven William Badelt
  • Patent number: 10646653
    Abstract: Methods for operating an injection device that is mated to a mobile device are disclosed. Methods include sensing movements of the injection device and enabling inputs on the mobile device based on the movements of the injection device. Methods also include receiving desired injection parameter values into the mobile device, transmitting signals indicative of injection parameters from the mobile device to the injection device, activating injection of medicament with the injection device in accordance with the signals received from the mobile device, and obtaining data regarding the administered injection from the injection device.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 12, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Mircea Stefan Despa, Sundeep Kankanala, Dylan Wilson
  • Patent number: 10646654
    Abstract: An autoinjector includes a case adapted to hold a medicament container having a needle telescopically coupled to the case and movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The autoinjector includes a plunger rotationally and slidably disposed in the case rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case engages the plunger to rotate the plunger from the first rotational position to the second rotational position when the needle shroud translates from the first extended position to the retracted position. The autoinjector includes a cap removably coupled to the case includes at least one compliant case beam adapted to releasably engage at least one aperture in the case.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 12, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Carsten Mosebach, Thomas Kemp
  • Patent number: 10646655
    Abstract: A syringe having a dispensing element (20) and having a mounting element (2), wherein the dispensing element (20) has a dispensing sleeve (21) and a leaf spring system (3), wherein the mounting element (2) has a syringe body (17), and an injection needle (16) is formed on one end on the syringe body (17) and a detent-engagement flange (19) is formed on the other end, wherein, in the syringe body (17), there is arranged a movable stopper (18), wherein the leaf spring system (3) comprises a piston (6) and a spiral spring (5) arranged around the piston (6), wherein the piston (6) can be slid into the dispensing sleeve (21), and the spiral spring (6) is arranged between a leaf spring base (22) and a spiral spring abutment, wherein the piston (6) abuts against the stopper (18), wherein the dispensing sleeve (21) has a guide duct and the dispensing sleeve (21) comprises a first locking means (7) and a second locking means (9), wherein the detent-engagement flange (19) is movable in the guide duct and is fixable and
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: May 12, 2020
    Assignee: F+K Innovationen GmbH & Co. KG
    Inventor: Karl-Heinz Fuchs
  • Patent number: 10646656
    Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: May 12, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Yannick Hourmand, Douglas Ivan Jennings, Matthew Ekman
  • Patent number: 10646657
    Abstract: The present disclosure describes an extended finger flange that facilitate use of syringe systems. The extended finger flange increases the surface area available for an end user's fingers thereby allowing a more secure grip on the device and providing greater control during administrations of the medication.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: May 12, 2020
    Assignee: SAFETY SYRINGES, INC.
    Inventor: Philip E. Dowds
  • Patent number: 10646658
    Abstract: An injection device includes: a housing defining a longitudinal axis; an operating element; a metering member held in the housing so as to be rotatable and fixed in the direction of the axis; the operating element, in a first position for setting a quantity to be dispensed, being mounted so as to be rotatable relative to the housing and rotationally fixedly connected to the metering member via a first coupling; the operating element, in a second position for dispensing, being rotationally fixedly connected to the housing via a second coupling and being rotatable in relation to the metering member; a first latching installation acting between operating element and housing, wherein the first latching installation is effective only in the operating element's first position; and, a second latching installation acting between operating element and metering member, wherein the second latching installation is effective only in the operating element's second position.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 12, 2020
    Assignee: Haselmeier AG
    Inventor: Joachim Keitel
  • Patent number: 10646659
    Abstract: Described is a medicament delivery device (1), comprising a body (2), a container carrier (7) for retaining a medicament container within the body (2) and being slidably disposed in the body (2), a sleeve (6) slidably coupled to body (2), and a piston rod (11) coupled to the body (2) and the container carrier (7). The piston rod (11) and the container carrier (7) provide a feedback as the container carrier (7) moves from a first position (P1) to a second position (P2) relative to the body (2).
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: May 12, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Winfried Huthmacher, Peter Nober
  • Patent number: 10646660
    Abstract: A method and apparatus are provided for use in locating a target region which is situated in the body of a subject, for example for the delivery of drugs. The system includes an assembly for controlling the flow of fluid from a fluid reservoir to a conduit, such as a needle. A sensor detects a characteristic indicative of the fluid pressure in the conduit. The system processes data from the sensor to detect the presence of a pulsatile waveform. A controller may control further operation of the system based on information regarding the presence of the pulsatile waveform and features of the waveform, such as amplitude.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: May 12, 2020
    Assignee: MILESTONE SCIENTIFIC, INC.
    Inventors: Mark N. Hochman, Richard K. Buck
  • Patent number: 10646661
    Abstract: A needle assembly for mounting on an injection device which comprises a body configured to be attached to an injection device in use; a double ended needle; and a needle shield coupled to the body. The needle shield is arranged for axial movement with respect to the body. The needle assembly has an injection configuration, in which the shield is positioned such that the forward tip of the needle projects beyond a forward end of the shield. The needle assembly also has a shroud configuration, in which the shield is positioned such that the forward end of the shield extends beyond the forward tip of the needle. The needle assembly further comprises a needle support fixed relative to the body when the needle assembly is in the injection configuration. Movement of the shield from the injection configuration to the shroud configuration axially displaces the needle support relative to the body.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: May 12, 2020
    Assignee: Owen Mumford Limited
    Inventor: Jack Calvert
  • Patent number: 10646662
    Abstract: An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: May 12, 2020
    Assignee: Antares Pharma, Inc.
    Inventors: Peter L. Sadowski, Paul R. Lesch, David L. Bremseth
  • Patent number: 10646663
    Abstract: The disclosure pertains to a safety syringe having a retractable needle shield which is capable of being retracted to expose the needle for use; being advanced to a needle shielding position; and, if desired, of being removed from the syringe with the shielded needle safely contained within the retractable needle shield via a frangible segment between the syringe barrel and the needle/needle shield components. The disclosure further pertains to a method of using the safety syringe having a retractable needle shield.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: May 12, 2020
    Assignee: Ultimed, Inc.
    Inventors: Thomas E. Erickson, James J. Erickson, Thomas Sauro
  • Patent number: 10646664
    Abstract: An injector for delivering a therapeutic product may include a base having a flexible surface that conforms to various body contours of a patient and defines one or more an injection chambers. The injector may have a height that is substantially less than its width, thereby defining a low profile, which provides a larger more stable base that can pinch or stretch the skin in a controlled manner. The larger base can also accommodate larger volumes via multiple injection chambers and/or large combined primary containers.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 12, 2020
    Assignee: AMGEN INC.
    Inventors: Mark Ka Lai Lee, Stephanie Toy, Valerie M. Fenster
  • Patent number: 10646665
    Abstract: A system for detecting and removing a gas bubble from a vascular infusion line, the system comprising: a disposable cassette adapted for disposition intermediate the fluid line, the disposable cassette comprising: a body comprising an inlet port, a chamber, an outlet port, and a purge port, a first passageway connecting the inlet port to the chamber, the first passageway comprising a first bubble detection section where a gas bubble may be detected within the first passageway, a second passageway connecting the chamber with the outlet port, and a first pinch valve disposed along the second passageway intermediate the chamber and the outlet port, and a third passageway connecting the chamber with the purge port, the third passageway comprising a second bubble detection section where a gas bubble may be detected within the third passageway, and a second pinch valve disposed along the third passageway intermediate the chamber and the bubble detection section.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: May 12, 2020
    Assignee: Clearline MD, LLC
    Inventors: Ihsan A. Haddad, David T. Healey
  • Patent number: 10646666
    Abstract: Described herein are cryolipolysis devices, systems, and methods for facilitating percutaneous access to a target blood vessel by performing cryolipolysis on subcutaneous adipose tissue obscuring the target blood vessel (e.g., a vessel used for hemodialysis treatment). Generally, the devices include a cooling member carrying a coolant that cools a selected portion of adipose tissue overlying the target blood vessel to reduce the selected portion of adipose tissue, thereby forming a depression in the adipose tissue and allowing the target blood vessel closer to the surface of the skin. In some variations, the cooling member is placed subcutaneously to directly cool the selected portion of adipose tissue. In other variations, the cooling member is placed external to the patient to indirectly cool the selected portion of adipose tissue through the skin.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: May 12, 2020
    Assignee: TVA Medical, Inc.
    Inventors: William E. Cohn, Thomas Diffley Pate, Adam L. Berman