Abstract: A system for identifying a location of a device includes a first antenna mounted to a plug. The first antenna surrounds one or more prongs of the plug, and the plug has a memory that stores a device ID. A second antenna receives the device ID from the first antenna when the plug is coupled to a power outlet. A controller uses a communication module to wirelessly transfer the device ID and a power outlet ID to a computer server. The computer server uses the device ID and the power outlet ID to determine the location of the device within a building.

Abstract: In some examples, devices, systems, and techniques are configured to compensate for changes in sensed blood pressure due to issues such as blood pressure sensor movement. For example, processing circuitry of a device may determine a difference value between a first blood pressure value representative of a blood pressure at a first time and a second blood pressure value representative of the blood pressure at a second time. Responsive to determining that the difference value is greater than or equal to a threshold value, the processing circuitry may generate updated blood pressure values by applying an offset value to the second blood pressure value and subsequently received blood pressure values that compensates for the difference value between the first blood pressure value and the second blood pressure value.

Abstract: An apparatus generates a pulse (or other hemodynamic) signal from an ECG signal, and displays a waveform of that signal. An ECG unit comprises electrode(s) for receiving an ECG signal waveform from live tissue and for generating a digital ECG signal; a memory storage; hardware processor(s) configured to constantly apply an integral function to the digital ECG signal and display a waveform of the integral function during a time period. The waveform of the integral function has a shape of a pulse signal waveform of the subject during the time period. The integral function comprises PWF(t)T=A?tt+TF(ECG(u))du ECG(u) represents an ECG over a specific time period using a specific time resolution. T is determined from the ECG(u) time resolution and pulse frequency, T satisfies the Nyquist sampling theory, t, u are time variables and A is a positive constant. The memory stores the integral function waveform. A weight function PWF(t)T=A?tt+TF(ECG(u))·W(u?t)du may be included.

Abstract: The invention provides a fluid analysis apparatus, a method for operating a fluid analysis apparatus, and a fluid analysis program that display a flow velocity vector such that the tendency of a fluid flow is easily checked. A representative two-dimensional flow velocity vector representing a plurality of two-dimensional flow velocity vectors obtained by projecting three-dimensional flow velocity vectors of a plurality of voxels that overlap each other in a projection direction of a projection plane to the projection plane is acquired from three-dimensional volume data that has information of the three-dimensional flow velocity vector indicating the flow velocity of a fluid in an anatomical structure for each voxel and is displayed.

Abstract: The invention provides a fluid analysis apparatus, a method for operating a fluid analysis apparatus, and a fluid analysis program that perform display such that the tendency of a fluid flow in a blood vessel is easily checked. Route position information that is capable of identifying an order along a route of the anatomical structure is assigned to each position in the anatomical structure, using three-dimensional volume data in which each voxel has the information of a three-dimensional flow velocity vector indicating a flow velocity of a fluid in an anatomical structure. The three-dimensional flow velocity vector is selected such that the route position information of a position where the three-dimensional flow velocity vector is present is sequentially arranged from one point in the anatomical structure and a trajectory indicating the flow of the fluid is drawn so as to be visibly recognized.

Abstract: A photoplethysmogram device is provided comprising a light source configured to emit light to illuminate skin, a photo-detector configured to receive the light illuminating the skin and generate an electrical output as a function of an intensity of the received light, a skin temperature regulator configured to heat and/or cool a temperature of the skin adjacent to the photo-detector and light source to increase the signal-to-noise ratio (SNR) of the electrical output from the photo-detector, and a processor configured to generate, based on the electrical output, an output signal indicative of blood properties, including physiological parameters such as blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance, blood vessel elasticity, and arterial oxygen saturation.

Abstract: An electronic device may include a display, a photoplethysmogram (PPG) sensor, a wireless communication circuit, a processor operatively connected to the display, the PPG sensor, and the wireless communication circuit, and a memory operatively connected to the processor. The electronic device implements the method, including monitoring blood glucose values of a user using the PPG sensor, displaying a notification prompting the user to measure blood glucose values using an external electronic device based at least partially on the monitored blood glucose values, and receive additional blood glucose values measured by the external electronic device using the wireless communication circuit.

Abstract: A structure for monitoring and stimulation includes an external power supply unit. The structure also includes an internal hub communicatively coupled to the external power supply unit. The structure further includes a plurality of sensor modules communicatively coupled to the internal hub by a plurality of flexible interconnects. The plurality of sensor modules include three-dimensional (3D) comb sensor devices.

Abstract: A computer implemented method includes supplying stimuli to an organism, measuring brain activity of the organism responsive to the stimuli and producing a brain feature activity map characterizing the brain activity. The operations of supplying, measuring and producing are repeated for different stimuli to form a brain feature activity map database. New stimuli are received. New stimuli features are mapped to a projected brain activity map. The projected brain activity map is compared to the brain feature activity map database to identify similarities and dissimilarities between the projected brain activity map and entries in the brain feature activity map database to designate a match. The new stimuli are characterized based upon the match.

Abstract: A method includes receiving (i) a plurality of electrocardiogram (ECG) signals acquired by a mapping catheter at a plurality of locations on a surface of a heart of a patient, (ii) a reference ECG signal from a reference catheter positioned at a nominal location in a coronary sinus (CS) of the patient, and (iii) position signals indicative of a position of the reference catheter in the CS. An electrophysiological (EP) map of at least part of the heart is calculated by time-referencing the ECG signals relative to the reference ECG signal. Based on the position signals, a displacement of the reference catheter from the nominal location in the CS, which distorts the time-referencing, is estimated. The distortion in the EP map is mitigated using the estimated displacement.

Abstract: An implantable device for analyzing a high frequency (HF) electrogram signal received from subcutaneous, above-rib pickup locations, the device including an implantable electrode for use inside a living body, and a can for subcutaneous implantation, the can including a signal pickup configured to pick up an electrogram signal including a high frequency (HF) component, a signal filter connected to the signal pickup and configured to measure a high frequency (HF) component from the electrogram signal, and an analyzer for analyzing the HF component of the electrogram signal, wherein the analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal, and the signal filter is configured to measure the electrogram signal by using a signal picked up from at least two pickup locations which are both subcutaneous and above-rib. Related apparatus and methods are also described.

Abstract: A system for marking cardiac time intervals from heart valve signals includes a non-invasive sensor unit for capturing electrical signals and composite vibration objects, a memory containing computer instructions, and one or more processors coupled to the memory. The one or more processors causes the one or more processors to perform operations including separating a plurality of individual heart vibration events into heart valve signals from the composite vibration objects, and marking cardiac time interval from the heart valve signals by detecting individual heartbeats using at least one or more of a PCA algorithm or deep learning.

Abstract: Devices and systems as described herein is configured to sense a signal, such as a signal from an individual. In some embodiments, a signal is a magnetic field. In some embodiments, a source of a signal is an individuals organ, such as a heart muscle. A device or system, in some embodiments, comprises one or more sensors, such as an array of sensors configured to sense the signal. A device or system, in some embodiments, comprises a shield or portion thereof to reduce noise and enhance signal collection.

Abstract: The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Abstract: A computer-implemented method for processing ECG data may include: receiving, over an electronic network, ECG data, wherein the ECG data represents a plurality of heartbeats; analyzing the ECG data, by at least one processor, to determine whether each of the plurality of heartbeats is a normal heartbeat or an abnormal heartbeat; associating, by the at least one processor, each of the abnormal heartbeats with either only one of a plurality of existing templates or a new template; receiving, from a user, input related to each new template, wherein the input includes either: a) a confirmation that the new template represents an abnormal heartbeat, or b) a reclassification of the new template as representing a normal heartbeat or a different abnormal heartbeat; and in response to the user input, updating, by the at least one processor, a label of each of the heartbeats associated with each confirmed new template and each of the heartbeats associated with each reclassified new template.

Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

Abstract: An implantable cardioverter defibrillator (ICD) performs a method that includes determining whether first criteria for detecting a ventricular tachyarrhythmia are met by a cardiac electrical signal. The ICD determines features from cardiac signal segment of a group of cardiac signal segments and determines whether a first portion of the features satisfy monomorphic waveform criteria and determines whether a second portion of the features satisfy supraventricular beat criteria. The ICD determines whether second criteria for detecting the ventricular tachyarrhythmia are met and withholds detecting of the ventricular tachyarrhythmia in response to the monomorphic waveform criteria and the supraventricular beat criteria being met.

Abstract: A three-dimensional (3D) comb probe structure includes a carrier, a plurality of combs arranged in the carrier and spaced apart from one another, a plurality of shanks forming the combs, each shank including a base portion and a stem portion extending from the base portion, wherein sets of the shanks are joined together by the base portions thereof to form a respective comb, and a plurality of sensing elements disposed along the stem portion of each of the shanks and electrically connected to electrical contacts disposed at respective ones of the base portions. The sensing elements can include nanopatterned features on surfaces thereof forming a non-random topography.

Abstract: The invention provides for a medical instrument (100, 400, 500, 600) comprising an activity measurement system (106) configured for measuring brain activity data (138) from a subject (102). The medical instrument further comprises a stimulus presentation system (108) configured for providing sensory stimulus to the subject. The medical instrument further comprises a memory (130) for storing machine executable instructions (132) and for storing a stimulus reinforcer database (134). The stimulus reinforcer database comprises entries. Each entry comprises commands configured for controlling the stimulus presentation system to provide the sensory stimulus to the subject. The medical instrument further comprises a processor (120) for controlling the medical instrument.

Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally (in the midline) on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and, to a lesser extent, the QRS interval signals indicating ventricular activity in the ECG waveforms. Additionally, the monitor recorder includes an ECG sensing circuit that measures raw cutaneous electrical signals and performs signal processing prior to outputting the processed signals for sampling and storage.

Abstract: To suppress the image quality deterioration due to respiratory motion and changes thereof, and improve the data acquisition rate. An MRI device according to the present invention repeats a main measurement in a predetermined unit, and performs a navigation measurement to acquire one or a plurality of the navigator echoes between the measurements in the temporally adjacent two predetermined units, and performs determination as to whether to continue or discontinue the main measurement and determination as to whether to discard immediately prior measurement data. In the determination, at least two navigator echoes are used, and by using a position of a site to be monitored by the navigation measurement and a displacement width serving as a reference of the displacement stability, whether the position and the displacement width satisfy a reference displacement and a reference displacement width, which have been obtained in advance, is determined.

Abstract: Methods and apparatus, including computer program products, are provided for activity tracking. In some example embodiments, there may be provided a method that includes deriving, from radio frequency based data, pseudo sensor data representative of at least an activity of a user, the pseudo sensor data derived based on at least a machine learning model configured to transform the radio frequency based data into the pseudo sensor data; and providing the pseudo sensor data. Related systems, methods, and articles of manufacture are also described.

Abstract: The disclosure describes assemblies for use during image-guided procedures and can include turret arms and/or longitudinally extending and laterally extending cooperating devices for holding surgical tools such as trajectory guides.

Abstract: An example method includes applying a localization signal to a source electrode positioned within a conductive volume and a ground electrode at a known location. Electrical activity is sensed at a plurality of sensor electrodes distributed across an outer surface of the conductive volume. The locations of each of the sensor electrodes and the location of the ground electrode being stored in memory as part of geometry data. The electrical activity sensed at each of the sensor electrodes is stored in the memory as electrical measurement data. The method also includes computing a location of the source electrode by minimizing a difference between respective pairs of source voltages determined for the plurality of sensor electrodes. The source voltage for each of the sensor electrodes is determined based on the electrical measurement data and the geometry data.

Abstract: Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

Abstract: Systems and methods for positioning an intracranial device are disclosed. Certain embodiments of the invention encompass devices configured for implantation within the body that include elements responsible for detecting and transmitting electrical activity from the surrounding tissues and fluids. The system may include associated hardware and software designed for transmitting, processing, analyzing, and displaying relevant aspects of detected electrical activity. This information can be used throughout or following an insertion procedure to optimize or confirm device position within a particular intracranial location or tissue compartment.

Abstract: The present invention includes a system and device for aiding in the diagnosis of a physiological abnormality resulting in detectable, measurable variations in contents of breathed air. The system includes a handheld unit defining an airway, wherein the airway includes a plurality of sensors adapted to measure a plurality of parameters related to the presence of a physiological abnormality. The system further includes a control unit remotely connected to the handheld unit. The control unit includes a controller adapted to receive input signals from the handheld unit and remit output signals in response thereto. The output signals are usable by a user in determining the presence or absence of a physiological abnormality. The control unit further also can include a display adapted to display the output signals to a user thereby easing the determination of the physiological abnormality. The system further includes a mouthpiece selectively connectable to the handheld unit.

Abstract: A wearable device for continuous monitoring of the respiratory rate of a patient, using a first inertial sensor positioned on the abdomen, a second inertial sensor positioned on the thorax, and a third inertial sensor being positioned on a part of the body not subject to respiratory movements, fixed with respect to the torso. Each inertial sensor includes a microprocessor connected to a transmitter configured for processing the signals and supplying a signal represented by a quaternion that describes the orientation of the inertial sensors with respect to the Earth's reference system. A receiver is configured for receiving the abdominal quaternion of the first inertial sensor, the thoracic quaternion of the second inertial sensor, and the reference quaternion of the third inertial sensor and sending them to a control center configured for calculating the respiratory rate from the signals represented by a filtered abdominal quaternion and a filtered thoracic quaternion.

Abstract: Systems and methods for mobile real-time breath ketone and exhaled gas detectors are described. For example, a device comprises an opening, providing a flow path through which a person breathes, a sensor, providing a ketone signal corresponding to a concentration of a respiratory component in exhalations of the person and including metabolic data, wherein the concentration of the respiratory component is associated with a level of ketone bodies in blood of the person, a display, and an electronic circuit, receiving the ketone signal and the metabolic data and providing a visual indication of the ketone signal and the metabolic data on the display.

Abstract: A portable incentive spirometry monitoring device and method of use. The device connected to the base of an incentive spirometer and is capable of monitoring inspiration within the incentive spirometer. The portable incentive spirometry monitoring device has a user interface for inputting a variety of different parameters, including a desired air volume, as well as attempt thresholds. Results can be stored such that medical personnel can review attempts by a patient to monitor therapeutic use, as well as encouraging patient use. The portable incentive spirometry monitoring device may be reused with different incentive spirometers without the need for extensive sterilization.

Abstract: A device and method for human intention detection Sensor Band (HID). In preferred embodiments, it makes use of an array of force sensing resistors (FSRs) which are embedded inside a flexible band, which is capable of reading the muscle activity for different motion type and muscle forcein a human user. In one implementation of the invention two of such bands are attached to the forearm and the upper arm. From the readings of the sensors, the patterns for motion type and muscle force are then distinguished autonomously by machine learning, a Support Vector Machine (SVM) algorithm, or a neural network. The method is advantageous e.g. the detection of dexterous motion of the arms, upon which assistive exoskeleton can be controlled for motion assistance. The invention can also be applicable to hand gestures recognition and bilateral rehabilitation, besides this the invention can be used to control lower body exoskeleton as well.

Abstract: A method of gait data collection, the method comprising collecting movement data, determining from the data a movement parameter that includes a third order derivative of position, comparing the movement parameter with a threshold value, and counting at least a near fall if the movement parameter exceeds the threshold value.

Abstract: An apparatus configured to, based on: a received daily target activity level for a user; and a received user daily activity profile for the user, the user daily activity profile comprising activity features each comprising specific intensity and specific duration at intervals throughout at least a portion of a day to cumulatively provide a particular activity level for the day, the user daily activity profile based on one or more of: at least one previous user daily activity profile of the user; and at least one previous user daily activity profile of one or more comparable users; generate an adjusted user daily activity profile comprising adjusted activity features each comprising one or more of adjusted specific intensity and adjusted specific duration at intervals throughout at least a portion of a day to cumulatively provide the daily target activity level for the user; and output the adjusted user daily activity profile for use by the user.

Abstract: A sensor cable support device is described. The sensor cable support device can be used to implemented in wearable monitoring device to support a proximal portion of a sensor cable and electrically connect the proximal portion with a sensing circuitry. A distal portion of the sensor cable is insertable into a person's skin. The sensor cable support device may include a rigid body defining a pair of openings, a set legs attached to the rigid body, and a pair of electrical traces extending between the pair of openings and distal ends of a pair of legs of the set of legs. The pair of openings may be sized and configured to receive a pair of pucks that mechanically retain a sensor cable to the body and electrically connect the sensor cable with the electrical traces.

Abstract: Compositions, devices, kits, and methods for calibrating at least one oxygen sensor in a blood gas, electrolyte, and/or metabolite instrument utilizing a calibration fluid comprising a pyrogallol oxygen scavenger.

Abstract: Disclosed is an apparatus for measuring bio signals. The apparatus for measuring bio signals includes: a sensor module configured to include a needle sensor to be inserted into the skin; and a main body to which the sensor module is separably coupled, and which is configured to include a controller controlling the sensor module to measure a bio signal through the needle sensor, once the sensor module is coupled.

Abstract: A measuring apparatus includes a light source configured to output light in a mid-infrared region, a detector configured to irradiate a measuring object with the light output from the light source and detect reflected light reflected by the measuring object, and a blood glucose level measuring device configured to measure a blood glucose level of the measuring object. A wavenumber between a plurality of absorption peak wavenumbers of glucose is used as a blood glucose level measuring wavenumber for measuring the blood glucose level.

Abstract: A system, device and methods for quantitatively monitoring and evaluating changes in water and hemoglobin content in the brain in a non-invasive manner are provided. The system may be used for real-time detection and monitoring of brain edema and/or for an assessment of cerebral autoregulation.

Abstract: A biological property testing device includes a base comprising a primary surface extending in a base plane, and a first lancet station supported by the base. A first test strip channel provided in the base can have a main channel portion extending generally parallel with the base plane, and an angled channel portion that forms an angle with the main channel portion between 5 degrees and 90 degrees. The first test strip channel can house a biological test strip oriented so that a meter connecting end of the biological test strip is adjacent to the main channel portion and a sample end of the biological test strip is adjacent to the angled channel portion.

Abstract: The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

Abstract: Blood samples are maintained in a modified atmosphere sealed environment, where moisture is reduced using a desiccant and oxygen is removed using a deoxygenation compound, thus resulting in the preservation of numerous blood analytes, for delayed (e.g., 14 days from collection) blood testing, such as for enzymatic activity, concentration of protein and measurement of other blood components in human and veterinary blood test applications.

Abstract: A kit for separating and concentrating body fluid cells is provided. The kit includes a first sealing cap provided with a first dose contact body; a first cap connection housing having a first inner connection body in which a first elastic body having a first slit line formed at an end thereof, with which the first close contact body comes into elastic contact when coupled to the first sealing cap, is inserted and disposed in an inner hole so that the first inner connection body is assembled with the first sealing cap; a first housing having one end screw-coupled to the first cap connection housing, and having an inner partition wall formed therein so that a first connection hole corresponding to the inner hole is formed through the inner partition wall; a central housing having one end screw-coupled to the other end of the first housing.

Abstract: A delivery device for delivering an instrument into a catheter assembly may include a syringe having a barrel and a plunger movable within the barrel. In response to depression of the plunger within the barrel, an instrument may be advanced distally. The instrument may include a catheter, a probe, a light tube for disinfection, or another suitable instrument. In response to depression of the plunger within the barrel, a distal end of the instrument may move through a catheter assembly coupled to the delivery device and into vasculature of a patient.

Abstract: A method of discovering relationships between eye physiology and cognitive and/or emotional responses of a user starts with engaging the user in a plurality of tasks configured to elicit a predicted specific cognitive and/or emotional response. A first camera films at least one eye of the user recording a time series of events of eye movements of the user, the camera not being in physical contact with the user. The first time series of eye movements are sent to a computing device which compares the eye movements and the plurality of events. The computing device can then identify at least one relationship between eye movements that correlate to an actual specific cognitive and/or emotional response.

Abstract: A shovel includes a lower traveling body, an upper turning body turnably mounted on the lower traveling body, a cab mounted on the upper turning body, an operating information obtaining device configured to obtain operating information, and a processor configured to store the operating information. The processor is configured to obtain the biological information of an operator in the cab and to correlate the biological information and the operating information.

Abstract: A device can screen swallowing safety and swallowing efficiency. The device includes a processor configured to receive accelerometry data, determine a an A-P and S-I signal summed spectrogram from the accelerometry data, and perform one or more of identifying a missing swallow, identifying that the data was clipped from the start, identifying that the data was clipped from the end, or identifying that the data contains noise. The device can have a user interface configured to provide one or more outputs including at least one of audio or graphics based on these identifications. If the data does not contain these signal quality issues, the device can compare the data against preset classification criteria defined for each of swallowing safety and swallowing efficiency and thus classify each of the swallowing events with a swallowing safety classification and a swallowing efficiency classification.

Abstract: Provided is a method for performing printing on a recording paper with a medical apparatus that continuously prints acquired biological information of a patient on the recording paper while feeding the recording paper. The method includes reading a first identification image attached to the recording paper; determining whether or not the recording paper is a genuine product on the basis of a comparison result between information based on the read first identification image and paper information previously stored in the medical apparatus; reading a second identification image attached to the recording paper, and determining whether or not the recording paper is within an expiration date on the basis of expiration date information included in information based on the read second identification image; and printing the biological information on the recording paper in a case where the recording paper is determined to be the genuine product and the recording paper is determined to be within the expiration date.

Abstract: There is shown and described a deep learning based system and method for skin diagnostics as well as testing metrics that show that such a deep learning based system outperforms human experts on the task of apparent skin diagnostics. Also shown and described is a system and method of monitoring a skin treatment regime using a deep learning based system and method for skin diagnostics.

Abstract: According to an example aspect of the present invention, there is provided method for measuring wound healing, comprising, measuring a wound impedance by a first tetrapolar arrangement of electrodes arranged on both sides of a wound, measuring a reference impedance by a second tetrapolar arrangement of electrodes arranged on one side of the wound, determining, by a controller, wound healing on the basis of the wound impedance and the reference impedance measured over a frequency range.