Patents Issued in June 9, 2020
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Patent number: 10676389Abstract: A glass article includes an alkali-alkaline-alumino-silicate composition, wherein the glass article has a coefficient of thermal expansion (CTE) in a range from about 110×10?7/° C. to about 130×10?7/° C. over a temperature range of 0-300° C.Type: GrantFiled: September 29, 2016Date of Patent: June 9, 2020Assignee: Corning IncorporatedInventors: Jeffrey Todd Kohli, Ronald Leroy Stewart
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Patent number: 10676390Abstract: The present invention discloses a glass-ceramic article and a glass-ceramic for an electric device cover plate, the glass-ceramic comprises, as a predominant crystalline phase, lithium silicate and the quartz crystalline phase, and has a composition expressed in weight percent including: SiO2: 65-85%, Al2O3: 1-15%, Li2O: 5-15%, ZrO2: 0.1-10%, P2O5: 0.1-10%, K2O: 0-10%, MgO: 0-10%, ZnO: 0-10%, and Na2O: 0-5%, wherein (SiO2+Al2O3+Li2O+ZrO2)/P2O5 is 40-90, the falling ball test height is 700 mm or more. By reasonable component design, the present invention achieves excellent mechanical properties of the glass-ceramic and the glass-ceramic article of the present invention and obtains the glass-ceramic or the glass-ceramic article suitable for electronic devices at a lower cost.Type: GrantFiled: December 18, 2018Date of Patent: June 9, 2020Assignee: CDGM GLASS CO., LTD.Inventor: Baoping Yuan
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Patent number: 10676391Abstract: Composite materials are provided which include a glass-ceramic matrix composition that is lightly crystallized, a fiber reinforcement within the glass-ceramic matrix composition which remains stable at temperatures greater than 1400° C., and an interphase coating formed on the fiber reinforcement. A method of making a composite material is also provided, which includes applying heat and pressure to a shape including fiber reinforcements and glass particles. The heat and pressure lightly crystallize a matrix material formed by the heat and pressure on the glass particles, forming a thermally stable composite material.Type: GrantFiled: June 19, 2018Date of Patent: June 9, 2020Assignee: FREE FORM FIBERS, LLCInventors: Shay L. Harrison, Joseph Pegna, John L. Schneiter, Erik G. Vaaler, Marvin Keshner
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Patent number: 10676392Abstract: Described are carbon nanotube dispersions containing single-walled carbon nanotubes dispersed in a dispersant solution comprising a solvent (water, organic polar protic solvents, and/or organic polar aprotic solvents), and an azo compound. The single-walled carbon nanotubes are not cross-linked with covalent bonds. The dispersions are useful for fabricating transparent conductive thin films on flexible and inflexible substrates. Methods for making the transparent conductive thin films are also described.Type: GrantFiled: January 20, 2017Date of Patent: June 9, 2020Assignee: Wisconsin Alumni Research FoundationInventors: Sundaram Gunasekaran, Ashok Kumar Sundramoorthy
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Patent number: 10676393Abstract: Embodiments disclosed therein generally pertain to selectively strengthening glass. More particularly, techniques are described for selectively strengthening cover glass, which tends to be thin, for electronic devices, namely, portable electronic devices.Type: GrantFiled: July 26, 2017Date of Patent: June 9, 2020Assignee: APPLE INC.Inventor: Douglas J. Weber
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Patent number: 10676394Abstract: Described herein are various antimicrobial glass articles that have improved resistance to discoloration when exposed to harsh conditions. The improved antimicrobial glass articles described herein generally include a glass substrate that has a low concentration of nonbridging oxygen atoms, a compressive stress layer and an antimicrobial silver-containing region that each extend inward from a surface of the glass substrate to a specific depth, such that the glass article experiences little-to-no discoloration when exposed to harsh conditions. Methods of making and using the glass articles are also described.Type: GrantFiled: November 9, 2018Date of Patent: June 9, 2020Assignee: Corning IncorporatedInventors: Yuhui Jin, Charlotte Diane Milia, Christine Coulter Wolcott
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Patent number: 10676395Abstract: An arrangement for burning lime mud into lime in a lime kiln. The lime mud flows counter-currently to flue gases from a feed end to a firing end and the fuel used is flue gas that is produced by gasifying a fuel in the presence of combustion air in a gasifier. The combustion air for gasification is preheated with heat generated in lime mud combustion. The arrangement is provided with a conduit between the lime kiln and the gasifier for leading air from the lime kiln into the gasifier as combustion air. At least a portion of the combustion air for gasification is preheated with heat generated in the lime mud combustion so that air is led into cooling of lime obtained in the combustion and further into the kiln, from or through the firing end of which air is taken into the gasification.Type: GrantFiled: May 9, 2017Date of Patent: June 9, 2020Assignee: Andritz OyInventor: Juhani Vehmaan-Kreula
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Patent number: 10676396Abstract: The invention pertains to a process for modifying gypsum, wherein a continuous feed of raw gypsum is provided; the water content of the raw gypsum is determined in the continuous feed by near infrared spectroscopy (NIR) measurement; the raw gypsum is calcined in a calcination unit at a fire rate to remove water from the raw gypsum and to obtain a continuous feed of calcined gypsum having a water content within a selected range; a water content of the calcined gypsum is determined by near infrared spectroscopy, and the fire rate is adjusted based on the water content of the raw gypsum and of the calcined gypsum. Further, the invention pertains to an apparatus for performing said process.Type: GrantFiled: November 18, 2016Date of Patent: June 9, 2020Assignee: KNAUF GIPS KGInventors: Olaf Johannsmann, Rainer Schulte, Juan Jose Ruiz
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Patent number: 10676397Abstract: A method for soil remediation by molecular binding for producing beneficial use determined polymer concrete product that removes hazardous pollutants from a quantity of contaminated soil. Hazardous pollutants are identified though chemical analysis in order to select at least corresponding polymer and at least one corresponding binder for each hazardous pollutant present in the contaminated soil. The at least one polymer chemically bonds with the hazardous pollutant in order to neutralize the hazardous pollutant within the contaminated soil to form a polymer concrete product. The polymer concrete product is then used as a concrete substitute for construction applications.Type: GrantFiled: December 22, 2016Date of Patent: June 9, 2020Inventors: Glenn Joseph Dominguez, Peter Pirozzi
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Patent number: 10676398Abstract: A sintered material includes cubic boron nitride grains and a binder, a grain size D50 of the cubic boron nitride grains when a cumulative value of the cubic boron nitride grains is 50% in an area-based grain size distribution being more than 0.5 ?m and less than or equal to 5 ?m, more than or equal to 70 volume % and less than or equal to 98 volume % of the cubic boron nitride grains being included in the sintered material, the binder being composed of A1-xCrxN, where 0?x?1, and a remainder, the remainder being composed of at least one of a first element and a compound including the first element and a second element, the first element being one or more elements selected from a group consisting of W, Co, Ni, Mo, Al, and Cr, the second element being one or more elements selected from a group consisting of nitrogen, carbon, oxygen, and boron.Type: GrantFiled: August 17, 2017Date of Patent: June 9, 2020Assignee: Sumitomo Electric Hardmetal Corp.Inventors: Kazushi Takahama, Yusuke Matsuda, Satoru Kukino
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Patent number: 10676399Abstract: Provided in one implementation is a method of manufacturing a three-dimensional object. The method can include depositing a substantially uniform layer of raw material onto a substrate. The raw material can include ceramic particles. The method can include selectively fusing particles of the raw material to form a first layer of the object. The method can include clearing non-fused particles of the raw material from the first layer of the object. The method can include repeating the steps of depositing a raw material, selectively fusing particles of the raw material, and clearing non-fused particles of the raw material to form additional layers of the object above the first layer.Type: GrantFiled: June 23, 2015Date of Patent: June 9, 2020Assignee: Applied Cavitation, Inc.Inventors: Joseph Albert Capobianco, Dana Lynn Hankey, Marshall Campion Tibbetts, Timothy Fahey
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Patent number: 10676400Abstract: The object of the present invention is an integrally bonded composite component, a method for the production thereof, and the use thereof. The invention particularly relates to integrally bonded transparent ceramic composite components, to a method for the production of such ceramic composite components, and to the use thereof.Type: GrantFiled: May 21, 2015Date of Patent: June 9, 2020Assignee: CeramTec-ETEC GmbHInventor: Lars Schnetter
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Patent number: 10676401Abstract: Oxalic acid is employed in a precursor mixture containing at least one milled alpha alumina powder having a particle size of 0.1 to 6 microns, boehmite powder that functions as a binder of the alpha alumina powders, and at least one burnout material having a particle size of 1-10 microns to provide a porous body having enhanced pore architecture in which extrusion cracks can be reduced. The presence of oxalic acid in such as precursor mixture can reduce and even eliminate NOx emission during a high temperature heat treatment process.Type: GrantFiled: April 23, 2018Date of Patent: June 9, 2020Assignee: Scientific Design Company, Inc.Inventors: Jean Adam, Michael Di Mare, Wojciech L. Suchanek
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Patent number: 10676402Abstract: A process for manufacturing an inorganic foam includes (i) separately preparing an aqueous foam and a cement slurry, the cement slurry including water W, a cement C, a water-reducing agent, a water-soluble calcium salt, a water-soluble silicate salt, the calcium/silicon molar ratio being 0.7 to 1.7 and the W/C weight ratio being 0.25 to 0.40, and given that the calcium ion concentration is 0.03 to 0.97%, expressed as weight percent relative to the weight of the cement, and that the silicate ion concentration is 0.04 to 1.67%, expressed as weight percent relative to the weight of the cement; (ii) contacting the cement slurry obtained with the aqueous foam to obtain a foamed cement slurry; and (iii) shaping the foamed cement slurry obtained in step (ii) and allowing setting to occur.Type: GrantFiled: November 17, 2016Date of Patent: June 9, 2020Assignee: HOLCIM TECHNOLOGY LTDInventors: Christian Blachier, Christine Chaumilliat, Hélène Lombois-Burger, Serge Sabio
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Patent number: 10676403Abstract: Protective coating systems for gas turbine engine applications and methods for fabricating such protective coating systems are provided. An exemplary protective coating system includes a substrate formed of a ceramic matrix composite material, a first coating layer formed directly on to the substrate and comprising an oxygen barrier material, a compliance material, or a bonding material and a second coating layer formed directly on to the first coating layer and comprising a thermal barrier material. The exemplary protective coating optionally includes a third coating layer partially formed directly on to the second coating layer and partially formed within at least some of the plurality of pores of the second coating layer.Type: GrantFiled: January 16, 2014Date of Patent: June 9, 2020Assignee: HONEYWELL INTERNATIONAL INC.Inventors: Reza Oboodi, Eric Passman, Bahram Jadidian
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Patent number: 10676404Abstract: A fertiliser comprising both sulphur and a solution of urea and ammonium nitrate in water is disclosed. Processes for making such a fertiliser are also disclosed.Type: GrantFiled: September 2, 2016Date of Patent: June 9, 2020Assignee: SHELL OIL COMPANYInventors: Rafael Alberto Garcia Martinez, Cyrille Paul Allais
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Patent number: 10676405Abstract: A process for preparing an elemental sulphur-containing composition for use as a fertilizer and/or soil improver comprises wet milling elemental sulphur in a liquid to produce a micronized sulphur slurry for application to soil, and further comprises adding a preventive scavenging additive for fixating sulphur dioxide and hydrogen sulphide gases that are released downstream of the mill.Type: GrantFiled: December 18, 2015Date of Patent: June 9, 2020Assignee: SHELL OIL COMPANYInventor: Cyrille Paul Allais
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Patent number: 10676406Abstract: Hopanoids, hopanoids-producing nitrogen-fixing bacteria, and related formulations, systems and methods are described herein. In particular, hopanoids alone or in combination with hopanoid-producing nitrogen-fixing bacteria can be used as biofertilizer to stimulate plant growth and yield with enhanced tolerance to diverse stresses found in plant-microbe symbiotic microenvironments.Type: GrantFiled: October 9, 2018Date of Patent: June 9, 2020Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Dianne K. Newman, Gargi Kulkarni, Brittany Jo Belin, Eric Giraud, Antonio Molinaro, Alba Silipo
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Patent number: 10676407Abstract: The present application provides a reactor with an inclined bottom gas-inlet for aerobic fermentation. A fermenter is provided with a circular inner tank, end covers and a jacket. An airtight fermentation space is formed in the fermenter by the inner tank, an upper end cover and a lower end cover. A feed opening and an exhaust outlet are arranged at an upper part of the fermenter, and a discharge opening is arranged at a lower part of the lower end cover of the fermenter. An energy-saving stirrer is mounted in the fermenter. A plurality of air chambers are arranged at an external wall at the bottom of the inner tank of the fermenter and are within the jacket. A plurality of aeration nozzles are defined on an inner side of each air chamber, and the aeration nozzles are disposed next to the inner tank.Type: GrantFiled: April 23, 2017Date of Patent: June 9, 2020Inventor: Shen Wang
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Patent number: 10676408Abstract: The invention concerns novel nitrification inhibitors.Type: GrantFiled: December 18, 2015Date of Patent: June 9, 2020Assignee: BASF SEInventors: Barbara Nave, Joachim Dickhaut, Peter Nesvadba, Mihiret Tekeste Sisay, Alexander Wissemeier, Wolfram Zerulla, Gregor Pasda, Olof Wallquist, Allan F. Cunningham
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Patent number: 10676409Abstract: An energetic composite comprises a metal powder; poly(vinylidene fluoride) (PVDF); and poly(lactic acid) (PLA). The metal powder comprises micrometer- or nanometer-sized particles, and the ratio of PVDF to PLA is between about 1:3 to 3:1. The metal powder comprises between about 4-32% wt of the energetic composite, and the metal powder consists of aluminum (Al), magnesium (Mg), or boron (B). A method of making an energetic composite material, comprises melt-blending a metal powder with poly(vinylidene fluoride) (PVDF) and poly(lactic acid) (PLA).Type: GrantFiled: March 31, 2017Date of Patent: June 9, 2020Inventors: Scott Iacono, Jena McCollum
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Patent number: 10676410Abstract: Embodiments disclosed herein related to processes and systems for alkane aromatization. In some embodiments, the process includes merging a benzene-containing stream into an ethane containing stream to form a feed stream. The feed stream has at least 5 wt. % benzene based on the total weight of the feed stream. In addition, the process includes contacting the feed stream with an aromatization catalyst to produce an effluent stream comprising C7+ aromatic hydrocarbons. Less than 5 wt. % net benzene is produced during the contacting, based on a total weight of the feed stream.Type: GrantFiled: April 23, 2018Date of Patent: June 9, 2020Assignee: ExxonMobil Chemical Patents Inc.Inventor: William J. Knaeble
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Patent number: 10676411Abstract: Processes for the production of olefins are disclosed, which may include: contacting a hydrocarbon mixture comprising linear butenes with an isomerization catalyst to form an isomerization product comprising 2-butenes and 1-butenes; contacting the isomerization product with a first metathesis catalyst to form a first metathesis product comprising 2-pentene and propylene, as well as any unreacted C4 olefins, and byproducts ethylene and 3-hexene; and fractionating the first metathesis product to form a C3-fraction and a C5 fraction comprising 2-pentene. The 2-pentene may then be advantageously used to produce high purity 1-butene, 3-hexene, 1-hexene, propylene, or other desired products.Type: GrantFiled: October 24, 2017Date of Patent: June 9, 2020Assignee: Lummus Technology Inc.Inventors: Sukwon Choi, Bala Ramachandran
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Patent number: 10676412Abstract: In a process for separating dimethyl biphenyl isomers a mixture comprising one or more 3,3?, 3,4?- or 4,4?-dimethyl biphenyl isomers, one or more 2,X?-dimethyl biphenyl isomers (where X=2, 3, or 4) and one or more further hydrocarbon components is contacted with a first adsorbent, thereby selectively adsorbing one or more of the dimethyl biphenyl isomers within the first adsorbent. A first raffinate stream containing less selectively adsorbed components is withdrawn from the first adsorbent and a first extract stream containing selectively adsorbed dimethyl biphenyl isomers is withdraw. The selectively adsorbed dimethyl biphenyl isomers comprise one or more of 3,3?-, 3,4?- or 4,4?-dimethyl biphenyl isomers and one or more of 2,X?-dimethyl biphenyl isomers (where X?=2, 3, or 4).Type: GrantFiled: March 27, 2019Date of Patent: June 9, 2020Assignee: ExxonMobil Research & Engineering CompanyInventors: Michael P. Lanci, Changyub Paek, Catherine M. Dorsi
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Patent number: 10676413Abstract: In a process for producing one or more 2,X?-dimethyl biphenyl isomers (where X=2, 3 or 4), a feed comprising toluene is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluene. At least part of the hydroalkylation reaction product is dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising dimethyl biphenyl isomers. The dehydrogenation reaction product is then separated into at least a first stream comprising one or more 3,3?-, 3,4?- and 4,4?-dimethyl biphenyl isomers and at least one second stream comprising one or more 2,X?-dimethyl biphenyl isomers (where X=2, 3 or 4).Type: GrantFiled: March 27, 2019Date of Patent: June 9, 2020Assignee: ExxonMobil Research & Engineering CompanyInventors: Michael P. Lanci, Changyub Paek, Catherine M. Dorsi
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Patent number: 10676414Abstract: A process for the manufacture of haloalkanes, or more particularly to a process for the manufacture of 1,1,1,3,3-pentachloropropane (HCC-240fa) and/or 1,1,1,3-tetrachloropropane (HCC-250fb). The process includes (a) mixing a catalyst, co-catalyst and a haloalkane starting material under conditions suitable to produce a homogeneous mixture; (b) reacting the homogeneous mixture with a haloalkene and/or alkene starting material under conditions suitable to produce a haloalkane product stream; and (c) recovering a haloalkane product from said product stream.Type: GrantFiled: August 21, 2017Date of Patent: June 9, 2020Assignee: Honeywell International Inc.Inventors: Hsueh Sung Tung, Ian Shankland
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Patent number: 10676415Abstract: Disclosed is a composition comprised of at least one compound selected from 2,3,3,3-tetrafluoropropene, 1,3,3,3-tetrafluoro-1-propene and 1-chloro-3,3,3-trifluoropropene and halogenated impurity selected from the group consisting of HFO-1141 (CH2?CHF), HCFO-1140 (CH2?CHCl), and HCFO-1131 (CH2?CFCl and/or trans/cis-CHF?CHCl) and combination thereof, said halogenated impurity being present in said composition in an amount of 50 ppm or less.Type: GrantFiled: October 12, 2018Date of Patent: June 9, 2020Assignee: Honeywell International Inc.Inventors: Haiyou Wang, Hsueh Sung Tung
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Patent number: 10676416Abstract: The invention relates to a process for methanol synthesis comprising the steps of providing a syngas feed stream comprising hydrogen and a mixture of carbon dioxide and carbon monoxide, wherein carbon dioxide represents from 1 to 50 mol % of the total molar content of the feed stream, carbon monoxide is contained from 0.1 to 85 mol % of the total molar content, and H2 is comprised from 5 to 95 mol % of the total molar content of the feed stream; providing an indium oxide catalyst selected from a bulk catalyst and a supported catalyst comprising indium oxide (In2O3) as the main active phase; putting in contact said stream with said catalyst at a reaction temperature of at least 373 K (99.85° C.) and under a pressure ranging of at least 1 MPa; and recovering the methanol effluents. The invention also relates to an indium oxide based catalyst.Type: GrantFiled: December 20, 2016Date of Patent: June 9, 2020Assignees: TOTAL RAFFINAGE CHIMIE, ETH ZURICHInventors: Daniel Curulla-Ferre, Charlotte Drouilly, Oliver Martin, Cecilia Mondelli, Javier Perez-Ramirez, Antonio J. Martin-Fernandez
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Patent number: 10676417Abstract: A halide compound having one or more carbon-carbon unsaturated bonds is catalytically reduced with substantially no dehalogenation to produce a reduced halide compound in which at least one of the one or more unsaturated bonds is reduced. Specifically provided is a method for producing a reduced halide compound including steps of: reacting a nickel compound, a zinc compound, and a borohydride compound in a solvent to obtain a reduction catalyst; and subjecting a halide compound having one or more carbon-carbon unsaturated bonds to catalytic reduction in the presence of the reduction catalyst to reduce at least one of the one or more carbon-carbon unsaturated bonds to thereby obtain a reduced halide compound.Type: GrantFiled: April 18, 2019Date of Patent: June 9, 2020Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Yuki Miyake, Takeshi Kinsho, Yusuke Nagae
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Patent number: 10676418Abstract: The present invention addresses the problem of providing a method for efficiently producing uniform microparticles of curcumin and/or ?-oryzanol at a higher yield. The target microparticles are produced by dissolving a starting material in a solvent to give a starting material solution and then subjecting the starting material solution to crystallization by a poor solvent method to thereby deposit the starting material. To prepare the starting material solution, curcumin and/or ?-oryzanol are used as the starting material(s) and ethanol is used as the solvent. The starting material(s) and the solvent are stirred in a pressurized state at a temperature of 78.3-130° C. inclusive to give the starting material solution. Then, the starting material solution thus obtained is subjected to crystallization by the poor solvent method and thus the target microparticles are produced.Type: GrantFiled: September 5, 2017Date of Patent: June 9, 2020Assignee: M. TECHNIQUE CO., LTD.Inventors: Masakazu Enomura, Kaeko Araki
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Patent number: 10676419Abstract: The method disclosed herein relates to two stage catalytic processes for converting syngas to acetic acid, acrylic acid and/or propylene. More specifically, the method described and claimed herein relate to a method of producing acrylic acid and acetic acid comprising the steps of: a) providing a feedstream comprising syngas; b) contacting the feedstream with a first catalyst to produce a first product stream comprising C2-C3 olefins and/or C2-C3 paraffins; and c) contacting the first product stream with oxygen gas and a second catalyst, thereby producing a second product stream comprising acrylic acid and acetic acid, wherein there is no step for separating the components of the first product stream before the first product stream is contacted with the second catalyst.Type: GrantFiled: September 25, 2018Date of Patent: June 9, 2020Assignee: SAUDI BASIC INDUSTRIES CORPORATIONInventors: Khalid Karim, Labeeb Chaudhary Ahmed
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Patent number: 10676420Abstract: A process for producing terephthalic acid, comprising: passing a feed stream through a catalytic reactor wherein the feed stream comprises p-xylene; contacting the feed stream with a catalyst within the catalytic reactor to produce an oxidation reaction wherein the catalyst comprises, less than or equal to 10% of a metal component wherein the metal component comprises cobalt ions, manganese ions, or a combination comprising at least one of the foregoing, less than or equal to 15% bromide ions, and less than or equal to 2% silver ions; and producing a product stream comprising terephthalic acid, wherein the product stream exits the catalytic reactor.Type: GrantFiled: October 17, 2016Date of Patent: June 9, 2020Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Syed Azhar Hashmi, Labeeb A. Chaudhary, Nedumbamana Sankaran
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Patent number: 10676421Abstract: The subject of the present invention is a process for the synthesis of C1-C10 alkyl (meth)acrylates, by direct esterification of the (meth)acrylic acid by the corresponding alcohol, the reaction being carried out in a fixed bed membrane reactor under conditions in which the water generated by the reaction is eliminated from the reaction mixture as it is formed. The process according to the invention may operate under conditions for which the reagents are not in excess, thereby minimizing the size and energy of the equipment for separation/recycling of the streams generated during the purification of the reaction medium.Type: GrantFiled: February 14, 2017Date of Patent: June 9, 2020Assignee: Arkema FranceInventors: Marianthi Elmaloglou, Anne Moreliere, Serge Tretjak
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Patent number: 10676422Abstract: The present invention relates to kinetic resolution of racemic ?-hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, racemic ?-hydroxyl esters were subjected to asymmetric catalytic hydrogenation to obtain extent optical purity chiral ?-hydroxyl esters and corresponding 1,5-diols. An optically active chiral ?-hydroxyl ester and 1,5-diols can be obtained at very high enantioselectivity and yield with relatively low usage of catalyst. The chiral ?-hydroxyl ester and 1,5-diols obtained by using the method can be used as a critical raw material for asymmetric synthesis of chiral drugs (R)-lisofylline and natural drugs (+)-civet, (?)-indolizidine 167B and (?)-coniine.Type: GrantFiled: August 8, 2015Date of Patent: June 9, 2020Assignee: ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD.Inventors: Qilin Zhou, Jianhua Xie, Xiaohui Yang, Lixin Wang
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Patent number: 10676423Abstract: Methods of synthesizing polyfluorinated amino acid derivatives are disclosed, along with polyfluorinated amino acid derivatives produced from said methods, as well as compositions containing same. The synthesis methods utilize an oxazolone and a perfluoroarene to produce the polyfluorinated amino acid derivatives.Type: GrantFiled: February 20, 2018Date of Patent: June 9, 2020Assignee: The Board of Regents for Oklahoma State UniversityInventors: Jimmie Dean Weaver, Kip Allen Teegardin, Amandeep Arora
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Patent number: 10676424Abstract: The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl); —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:Type: GrantFiled: September 17, 2018Date of Patent: June 9, 2020Assignee: The Research Foundation for the State University of New YorkInventors: Ming-Yu Ngai, Katarzyna N. Hojczyk
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Patent number: 10676425Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same, for treating a neurodegenerative diseases.Type: GrantFiled: September 24, 2015Date of Patent: June 9, 2020Assignee: MEGABIOWOOD CO., LTDInventors: Ki Duk Park, ChangJoon Justin Lee, Dong Jin Kim, Ae Nim Pae, Hyun Ah Choo, Sun Joon Min, Yong Koo Kang, Yun Kyung Kim, Hyo Jung Song, Ji Won Choi, Min Ho Nam, Jun Young Heo, Seul Ki Yeon, Bo Ko Jang, Eun Ji Ju, Seon Mi Jo, Jong-Hyun Park
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Patent number: 10676426Abstract: The present invention is directed to reactor systems and processes for producing acrylonitrile and acrylonitrile derivatives. In preferred embodiments of the present invention, the processes comprise the following steps: introducing an epoxide reagent and carbon monoxide reagent to at least one reaction vessel through at least one feed stream inlet; contacting the epoxide reagent and carbon monoxide reagent with a carbonylation catalyst to produce a beta-lactone intermediate; polymerizing the beta-lactone intermediate with an initiator in the presence of a metal cation to produce a polylactone product; heating the polylactone product under thermolysis conditions to produce an organic acid product; optionally esterifying the organic acid product to produce one or more ester products; and reacting the organic acid product and/or ester product with an ammonia reagent under ammoxidation conditions to produce an acrylonitrile product.Type: GrantFiled: June 29, 2018Date of Patent: June 9, 2020Assignee: Novomer, Inc.Inventor: Sadesh H. Sookraj
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Patent number: 10676427Abstract: The present invention relates compounds useful as reagents for the diazomethylation reaction, their preparation and the use thereof as reagents in a method for the diazomethylation reaction of aromatic substrates. It relates in particular to a compound of formula (I) wherein E is an electron withdrawing group.Type: GrantFiled: February 8, 2018Date of Patent: June 9, 2020Assignee: FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ)Inventors: Marcos García Suero, Zhaofeng Wang
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Patent number: 10676428Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.Type: GrantFiled: December 19, 2016Date of Patent: June 9, 2020Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Nir Ben-Tal, Roger S. Armen, Laurence C. Eisenlohr, Jitendra Belani, Michael Miller, Inbar Fish, Ori Kalid
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Patent number: 10676429Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.Type: GrantFiled: August 28, 2013Date of Patent: June 9, 2020Assignee: Janssen Sciences Ireland UCInventors: Koen Vandyck, Stefaan Julien Last, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
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Patent number: 10676430Abstract: The present disclosure is related to non-alpha-substituted, low molecular weight peracid compositions. The peracids have no or a negligible amount of odor, have good stability, and have antimicrobial properties. The peracid compositions can be formulated into a wide variety of end use products, including disinfectants, sanitizers, sporicides, fungicides, laundry products, hard surface cleaners, bleaching agents, personal cleansers, and water treatment products.Type: GrantFiled: September 19, 2018Date of Patent: June 9, 2020Assignee: Stepan CompanyInventors: Sangeeta Ganguly-Mink, Kenneth J. Littel, Shui Ping Zhu
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Patent number: 10676431Abstract: The disclosure relates to compounds of Formulae (I)-(IX), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.Type: GrantFiled: March 4, 2019Date of Patent: June 9, 2020Assignee: Bristol-Myers Squibb CompanyInventors: Pravin Sudhakar Shirude, Vishweshwaraiah Baligar, Balaji Seshadri, Amit Kumar Chattopadhyay, Nicholas R. Wurtz, Ellen K. Kick
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Patent number: 10676432Abstract: The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.Type: GrantFiled: August 21, 2018Date of Patent: June 9, 2020Assignee: Supernus Pharmaceuticals, Inc.Inventors: Martin Hanbauer, Zarghun Nazir, Peter Hildebrand, Attilia Figini, Likan Liang, Tiziano Fumagalli
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Patent number: 10676433Abstract: The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.Type: GrantFiled: January 31, 2019Date of Patent: June 9, 2020Assignee: Merck Patent GmbHInventor: Srinivasa R. Karra
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Patent number: 10676434Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.Type: GrantFiled: April 10, 2019Date of Patent: June 9, 2020Assignee: Bristol-Myers Squibb CompanyInventors: Saleem Ahmad, Douglas G. Batt, Qingjie Liu, John E. Macor, Joseph A. Tino, Scott Hunter Watterson, Satheesh Kesavan Nair, Tarun Kumar Maishal
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Patent number: 10676435Abstract: The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid (Compound 1) in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in the vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).Type: GrantFiled: April 9, 2019Date of Patent: June 9, 2020Assignee: Arena Pharmaceuticals, Inc.Inventors: Anthony C. Blackburn, Ryan O. Castro, Mark Allen Hadd, You-An Ma, Antonio Garrido Montalban, Jaimie Karyn Rueter, Lee Alani Selvey, Sagar Raj Shakya, Marlon Carlos
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Patent number: 10676436Abstract: Provided are compounds that target the nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) pathway. The compounds can be used to treat multiple conditions, including inflammatory, immune-mediated, and/or chronic inflammatory gastrointestinal diseases; systemic immune-mediated diseases; cancers; and infectious diseases.Type: GrantFiled: July 2, 2019Date of Patent: June 9, 2020Assignee: LANDOS BIOPHARMA, INC.Inventors: Josep Bassaganya-Riera, Andrew Leber, Raquel Hontecillas
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Patent number: 10676437Abstract: The application relates to 4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3 potassium channel modulators, and methods of their uses.Type: GrantFiled: December 13, 2018Date of Patent: June 9, 2020Assignee: SciFluor Life Sciences, Inc.Inventors: Takeru Furuya, Ben C. Askew, D. Scott Edwards
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Patent number: 10676438Abstract: The present invention relates to a compound represented by the general formula (I) (wherein the definition of each group has the same meaning as described in the specification). The compound is useful as preventive and/or therapeutic agent for KCNQ2-5 channel-related diseases.Type: GrantFiled: August 9, 2018Date of Patent: June 9, 2020Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kentaro Yashiro, Daisuke Wakamatsu, Tetsuji Saito