Patents Issued in June 30, 2020
  • Patent number: 10695482
    Abstract: The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: June 30, 2020
    Assignee: SeaStar Medical, Inc.
    Inventors: H. David Humes, Deborah A. Buffington, Christopher J. Pino
  • Patent number: 10695483
    Abstract: The present invention discloses a self-sealing cannula that through a self-sealing mechanism fixed on the ventricular wall or atrial wall, the cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula; in the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: June 30, 2020
    Assignee: University of Maryland, Baltimore
    Inventors: Zhongjun Wu, Bartley P. Griffith, Keshava Rajagopal
  • Patent number: 10695484
    Abstract: System and method for accessing and treating a patient's cerebrospinal fluid. The system comprises a device with at least one implantable single or multilumen catheter, configured for placement along a patent's cerebrospinal fluid pathway, with at least one domed subcutaneous reservoir and/or pump connected to the catheter(s). The device can also be equipped with control circuitry and controllable valves. The devices allow for drug administration and/or simultaneous, bidirectional cerebrospinal fluid access and exchange. The catheter(s), may be coupled with medical probes that transmit sensor data to the device's processor, which can be configured transmit and receive data and instructions. The catheters may also be configured with guide devices to facilitate implantation. Various configurations, from single dome to multiple dome devices are taught, along with various applications such as epidural and other cerebrospinal drug administration, and various medical diagnostic applications.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: June 30, 2020
    Inventor: Milan Radojicic
  • Patent number: 10695485
    Abstract: A wearable drug delivery device that can deliver high volumes of liquid drugs stored in one or more corresponding containers to a patient is provided. The wearable drug delivery device can include first and second containers to store first and second liquid drugs, respectively. A first set of energy transfer spheres can be coupled to a first spring and a first plunger positioned within the first container. A second set of energy transfer spheres can be coupled to a second spring and a second plunger positioned within the second container. The first spring can expand to advance the first set of energy transfer spheres and the first plunger to expel the first liquid drug for delivery to the patient. The second spring can expand to advance the second set of energy transfer spheres and the second plunger to expel the second liquid drug for delivery to the patient.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: June 30, 2020
    Assignee: Insulet Corporation
    Inventor: David Nazzaro
  • Patent number: 10695486
    Abstract: A liquid drug-filtering filter medium is provided, which can include a nanofiber web having a three-dimensional network structure for filtering foreign substances included in a liquid drug. According to the embodiment, the occurrence of differential pressure when drawing in and filtering a liquid drug is minimized, and thus the liquid drug may be quickly drawn into a syringe cylinder within a short time and by applying small force, and at the same time, the filtration rate of foreign substances in the liquid drug is very outstanding. A method for producing the liquid drug-filtering filter medium is also provided, which enables the very easy adjustment of a pore structure of the filter medium or the diameters of the pores in order to enable the pore structure to minimize the occurrence of differential pressure or change the differential pressure to a target level.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: June 30, 2020
    Assignee: AMOGREENTECH CO., LTD.
    Inventors: In Yong Seo, Ui Young Jeong
  • Patent number: 10695487
    Abstract: A controlled delivery drive mechanism includes a drive housing, a piston, and a biasing member initially retained in an energized state and is configured to bear upon an interface surface of the piston. The piston is configured to translate a plunger seal and a barrel. A tether is connected between the piston and the winch drum to restrain the free expansion of the biasing member and the free axial translation of the piston upon which the biasing member bears upon. The drive mechanism may further include a gear assembly and an escapement regulating mechanism configured to control the rotation of the gear assembly to release the tether from the winch drum. The metering of the tether by the escapement regulating mechanism controls the rate or profile of drug delivery to a user.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 30, 2020
    Assignee: UNL Holdings LLC
    Inventors: Ian B. Hanson, Paul F. Bente, IV, Mark A. Destefano
  • Patent number: 10695488
    Abstract: A device for limitation of the injection pressure of a medical instrument for introduction of a fluid, having a housing, with an entrance of the housing for introducing the fluid at an inlet pressure, with an outlet of the housing for introducing the fluid to the instrument, with a flow-through channel of the housing connecting the entrance and the outlet and with a plunger guided in the housing which is impinged on by the pressure of the fluid and through this pressure is movable against a resetting force. On the plunger a blocking element is arranged, which is located in the flow cross section of the flow-through channel, and that the blocking element releases the flow cross section, when the pressure of the fluid impinging on the plunger lies beneath a value preset by the resetting force, and blocks the flow cross section when the pressure of the fluid impinging on the plunger exceeds this preset value and moves the plunger against the resetting force.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 30, 2020
    Assignee: Pajunk GmbH Medizintechnologie
    Inventors: Xavier Capdevila, Olivier Choquet, Siddharth Desai
  • Patent number: 10695489
    Abstract: There is provided a fluid delivery system (100), comprising a pump (102) for pumping fluid from a cartridge (400) to an outlet. The pump comprises a housing (302), a cartridge which can be removably attached to the housing, and a switch (308) for activating the pump. The switch is arranged such that attaching the cartridge to the housing activates the switch to automatically activate the pump. The system may also include a control unit for wireless connection with the pump.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: June 30, 2020
    Assignee: VICENTRA B.V.
    Inventors: Timothy William Oakes, Joseph Cefai
  • Patent number: 10695490
    Abstract: A semi-automated system (100) suitable for use in a hospital setting for filling patient-specific liquid medication prescriptions from bulk medicine containers (104) into oral/enteral syringes (S) for administration on a just-in-time basis. The system enables hospital pharmacists to simplify and streamline their task, increasing the number of prescriptions that can be filled in a day, improving patient safety and care by minimizing medication errors and the consequences that ensue.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: June 30, 2020
    Inventors: Nicholas J Perazzo, Robert A Rosen, John G Grosskopf, Jr., Mark Bennett, John M Chopper
  • Patent number: 10695491
    Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: June 30, 2020
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Shane Alistair Day, Daniel Thomas De Sausmarez Lintell, Steven Wimpenny, Christopher Jones, Aidan Michael O'Hare, Barry Yates, Robert Frederick Veasey, Christopher James Smith, Malcolm Boyd, David Martin Leak, Carmen Patricia Keating, David Sanders, Elizabeth Anne Marshall
  • Patent number: 10695492
    Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir and a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient. The drug delivery system may further include one or more sensors coupled to the drug delivery device, a wireless transmitter, and a controller coupled to the one or more sensors and the wireless transmitter. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device, and control the wireless transmitter to wirelessly transmit one or more reports representative of the condition or the operational state of the drug delivery device. A method for use with a drug delivery device is also disclosed.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: June 30, 2020
    Assignee: AMGEN INC.
    Inventors: Adam B. McCullough, Ferry Tamtoro, Huaying Yang, Mark Ka Lai Lee, Desheng Yin, Scott R. Gibson, Donald Busby, Peter V. Shultz, Keith P. Kogler, Jimmie L. Ward, Christopher R. Folk, Steven William Badelt
  • Patent number: 10695493
    Abstract: A pen includes a carpule having a longitudinal axis, a first end with a dispensing opening closable by a closure part, a second end via which at least one stopper can be inserted in the direction of the longitudinal axis, and an interior that is tightly closed by the closure part and the at least one stopper. A pen housing has a central axis, receives the carpule, and has a piston rod that interacts with the at least one stopper and a drive for moving the at least one stopper within the interior of the carpule, wherein the second end of the carpule can be inserted into the housing.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: June 30, 2020
    Assignee: VETTER PHARMA-FERTIGUNG GMBH
    Inventors: Tilman Roedle, Tobias Kistler, Sarah Kühnle, Roland Limbeck
  • Patent number: 10695494
    Abstract: The invention relates to a needleless injection device, comprising a firing chamber (11) for the needleless injection of a substance (25), having a firing chamber containing a pyrotechnic material and a gel-like medium, with which a substance, in particular an active substance, can be accelerated at high speed and injected in a needleless manner into a tissue or into a body by means of a membrane (15). The invention also relates to a method for producing a needleless injection device of this type containing a firing chamber together with pyrotechnic material and filled with a gel-like medium, and use thereof.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: June 30, 2020
    Inventor: Peter Lell
  • Patent number: 10695495
    Abstract: An apparatus includes a housing, an actuator, a lock mechanism, and a medicament container. The lock mechanism selectively engages a portion of the housing such that (1) the lock mechanism is maintained in a substantially fixed position when the housing is in a first orientation and (2) the lock mechanism is removable from the housing when the housing is in a second orientation. The medicament container is moved in a proximal direction when the lock mechanism is removed from the housing to mix a first medicament portion contained within the medicament container with a second medicament portion contained within the medicament container. The actuator can be moved from a first position to a second position when the lock mechanism is removed from the housing to release energy stored within an energy storage member such that the medicament container is moved in a distal direction.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 30, 2020
    Assignee: kaleo, Inc.
    Inventors: Frank E. Blondino, Eric S. Edwards, Evan T. Edwards, Paul F. Meyers
  • Patent number: 10695496
    Abstract: A cartridge comprising a reservoir part and an extension extending from said reservoir part, said extension defining a fluid path and comprising a molding and a first needle extending from said molding, the extension turning to a finite angle with respect to an axis of said reservoir part and wherein at least part of said first needle is likewise at said finite angle, at least some of said part of said first needle at said finite angle being enclosed within said molding of said fluid path. A drug delivery device may be used with the cartridge and includes a skin-contacting surface. In use the longitudinal axis of the interior of the cartridge may be disposed substantially parallel to the skin-contacting surface.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: June 30, 2020
    Assignee: WEST PHARMA. SERVICES IL, LTD.
    Inventors: Paul H. Norton, Oz Cabiri, Ran Hezkiahu, Hubert Jansen
  • Patent number: 10695497
    Abstract: A manual subcutaneous jet injector includes an injector body having an injection portion provided with an injection system including an injection fluid volume fluidically connected to a subcutaneous injector outlet, and a pumping portion. The pumping portion includes an interior chamber having a pumping portion and a pressure chamber portion fluidically connected to the injection fluid volume. A manually operated injector pump is arranged in the pumping portion. At least one one-way valve is arranged between the pumping portion and the pressure chamber portion, the one-way valve including an inlet end and an outlet end. A piston is arranged in the pumping portion at the inlet end of the one-way valve.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: June 30, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Andrew C. Hicks, Alex M. Hytha
  • Patent number: 10695498
    Abstract: A method of manually charging a subcutaneous jet injector includes shifting a piston arranged within a pressure chamber portion of the subcutaneous jet injector, forcing a fluid through a one-way valve with the piston into a chamber of the subcutaneous jet injector, pressurizing the fluid in the chamber creating a pressurized fluid, forcing the pressurized fluid in the chamber into another chamber including a bolus dose of injectable fluid, and directing the bolus dose of injectable fluid from the subcutaneous jet injector with the pressurized fluid.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: June 30, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Andrew C. Hicks, Alex M. Hytha
  • Patent number: 10695499
    Abstract: The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member (20, 22, 120, 122) and a piston rod guide (40, 140) in a housing (10, 110) such that the piston rod member extends through a guide structure (13, 113) fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rotation with respect to the housing, bringing a displaceable wall (62, 162) of a variable volume drug reservoir (60, 160) into abutment with a distal end portion of the piston rod member, movin
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 30, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Carsten Schau Andersen, Simon Roervig, Steffen Hansen
  • Patent number: 10695500
    Abstract: A mechanism for a drug delivery device includes a body, a dial that is moved with respect to the body for setting a dose, and an indicator member coupled with the dial. A movement of the dial generates a helical movement of the indicator member, and a movable window is coupled to the indicator member.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: June 30, 2020
    Assignee: Sanofi
    Inventor: Simon Lewis Bilton
  • Patent number: 10695501
    Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring a volume or number of doses remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a light guide disposed and configured to reflect electromagnetic radiation toward the container. The dose measurement system also includes a light guide disposed and configured to emit electromagnetic radiation into the light guide. A plurality of sensors are located in the apparatus that are optically coupleable to the light guide and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light guide. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: June 30, 2020
    Assignee: Common Sensing Inc.
    Inventors: Kevin Sihlanick, Richard Whalley, Matthew Legrand, James White, Jeffrey Carothers
  • Patent number: 10695502
    Abstract: A drive mechanism of a drug delivery device and a respective drug delivery device for setting and dispensing of a dose of a medicament are presented, where the drive mechanism has an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge containing the medicament, a dosing arrangement manually and axially displaceable relative to the housing for setting and dispensing of the dose, and an accessory drive operably engaged with the piston rod to support a manually operated dose dispensing displacement of the dosing arrangement.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: June 30, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Paul Richard Draper, Anthony Paul Morris, Stephen Francis Gilmore
  • Patent number: 10695503
    Abstract: The present disclosure is directed to a drive sleeve with a hollow body having a ring of crown teeth with a first outer diameter forming a clutch interface at a first end and a thread extending on an outer surface of the body. The thread has a major diameter and a minor diameter, wherein the ring of crown teeth has at least two cavities. The at least two cavities extend on the outer surface of the body from the first end to the thread and defining a second outer diameter which is smaller than the major diameter of the thread. Further, some embodiments are directed to a drug delivery device with such a drive sleeve and a method for assembling a drug delivery device.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: June 30, 2020
    Assignee: Sanofi
    Inventors: William Marsh, Anthony Paul Morris
  • Patent number: 10695504
    Abstract: A drug delivery system comprises means to create a log of expelled dose amounts of drug. Stored dose amounts determined within a given time period are combined to a single combined dose amount. The given time period is initiated by a detected expelling event taking place (i) a given amount of time after a previous detected expelling event, or (ii) after a given detected action. By this arrangement it is possible to create a log corresponding to what a user considers to be a single dose, i.e. combining “split doses” to create a single log entry for a per se split dose.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: June 30, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Preben Mikael Nielsen, Nikolaj Frogner Krusell, Jens Christian Andersen, Nikolaj Eusebius Jakobsen
  • Patent number: 10695505
    Abstract: A discharger comprising a housing, a piston arranged inside the housing and being movable between a first piston position and a second piston position, a hollow cylindrical container inside the housing, the container being movable between a first container position and a second container position, a first compartment defined within the housing, a second compartment defined within the container, an axially extending passage in the interior of the piston and in communication with the first compartment and a peripheral opening of the piston in the region of a proximal end of the piston, a sealing element configured to prevent communication between the second compartment and the peripheral opening of the piston when the container is in a first container position, and a releasable retaining device configured to retain the piston in a piston first position until the container has reached a second container position.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: June 30, 2020
    Assignee: SULZER MIXPAC AG
    Inventor: Josef Ettlin
  • Patent number: 10695506
    Abstract: A drug injection device (10) including a housing (12) for holding a container (20) having a needle (24) for penetrating skin and a plunger (42) for expelling a drug stored in the container. The device includes visual and/or audible indicators for indicating that the correct depth of needle penetration has been achieved and that drug injection/extrusion has been started and/or completed. The device may further include a label (140) for visually confirming the quality of the drug contained therein. Alternatively, a tray (110) may be provided for receiving the drug injection device, which allows the quality of the drug contained therein to be visually confirmed.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: June 30, 2020
    Assignee: AMGEN INC.
    Inventors: Peter V. Shultz, Christopher R. Folk, Sigrid Moeslinger, Masamichi Udagawa, Molly Evans, Lin Gao, Lisa Nugent
  • Patent number: 10695507
    Abstract: A needle tip (22) for being connected and disconnected in use from a needle tip support (16), comprises a needle (24) having a forward end and a rearward end and, a connector secured to the needle intermediate its ends. The connector comprises two arms (28) each extending outwardly and rearwardly relative to the needle (16) and configured to be coupled and uncoupled in use from said needle tip support, and the arms are disposed on opposite sides of the needle. Also disclosed are arrangements for storing, dispensing and later disposing such needle tips, as well as coupling interfaces between the needle tip and a needle support cap to which it is fitted in use.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: June 30, 2020
    Assignee: Owen Mumford Limited
    Inventors: Timothy Evans, Toby Cowe, Colin Webb
  • Patent number: 10695508
    Abstract: An instrument is applied to body tissue of a body part to produce vibration to thereby reduce pain of injection or other pain producing stimulus. The device has a frame, and a source of vibration connected to the frame. A removable tip is connectable to the frame which has a distal end that is connected to the source of vibration when the tip is connected to the frame, to thereby vibrate the distal end when the source of vibration is activated. At the distal end of the tip are mutually facing arms which define an opening between them. Each arm forms a projection which extends at an angle from the arm. The projections are shaped to fit the body part so that the arms and projections are sized and dimensioned to position, retain, and transmit vibration to the body part in a position proximate the opening.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: June 30, 2020
    Assignee: BING INNOVATIONS, LLC
    Inventors: Mark Lorberbaum, Philip Ralabate, Paul Dicesare
  • Patent number: 10695509
    Abstract: A negative pressure injection device which includes a suction cup and an inner skirt that encircles an injection port and depends into the interior of the suction cup. An injection member is surrounded by and protrudes below the inner skirt. When air is drawn from the suction cup an epidermis of a patient is drawn into the suction cup until the epidermis comes into contact with the inner skirt and that portion of the injection member protruding below the inner skirt. The inner skirt provides consistent epidermis positioning. The depth of injection is consistently defined by the extent to which the injection member protrudes below the inner skirt.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: June 30, 2020
    Assignee: BIOPREME MEDICAL TECHNOLOGIES INC.
    Inventors: Alexsandr Kavokin, Nigel Anthony Syrotuck, Mark Sasha Drlik
  • Patent number: 10695510
    Abstract: A novel aromatherapy vaporization device is disclosed having a first and second housing with a heating chamber for receiving of phyto material. The heating chamber has an ambient air input port that receives ambient air that does not flow past hot electrical components when entering the heating chamber. An inhalation tube is coupled with the heating chamber for receiving of phyto material vapor therein in a second mode of operation and in a first mode of operation the inhalation tube is uncoupled from the heating chamber to allow for loading of phyto material therein.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: June 30, 2020
    Assignee: Vapium Inc.
    Inventor: Michael Trzecieski
  • Patent number: 10695511
    Abstract: A method and assembly for calibrating the pneumatic performance range of a system for delivering pneumatic power to a trocar, which includes the steps of: supplying pneumatic power to a trocar to achieve a desired cavity pressure; measuring the pneumatic power and cavity pressure over a time period, as the system attempts to maintain the desired cavity pressure; calculating performance characteristics of the trocar based on the measured cavity pressure and pneumatic power values; and adjusting the pneumatic power supplied to the trocar based upon the performance characteristics of the trocar.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: June 30, 2020
    Assignee: Conmed Corporation
    Inventors: Kenneth Varner, Mikiya Silver
  • Patent number: 10695512
    Abstract: An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 30, 2020
    Assignees: Ivax Pharmaceuticals Ireland, Norton (Waterford) Limited, Teva Pharmaceuticals Ireland
    Inventors: Declan Walsh, Derek Fenlon, Simon Kaar, Jan Geert Hazenberg, Daniel Buck, Paul Clancy, Robert Charles Uschold, Jeffrey A. Karg
  • Patent number: 10695513
    Abstract: A breathing assistance apparatus includes an inner volumetric member pressurizable from a first pressure to a second pressure and an outer volumetric member surrounding at least a portion of the inner expandable volumetric member. The inner volumetric member pressurizes the outer volumetric member as the inner volumetric member is pressurized from the first pressure to the second pressure. In another embodiment, a breathing assistance apparatus includes exhalation and inhalation chambers with respective biasing members providing for the exhalation chamber to apply a pressure to the inhalation chamber and thereby provide assisted inhalation. Methods for assisting breathing are also provided.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: June 30, 2020
    Assignee: Trudell Medical International
    Inventors: Jean-Pierre Robitaille, Stephen Costella, Jennifer Pevler, James Schmidt
  • Patent number: 10695514
    Abstract: A breathing system for an anesthesia machine is provided, which comprises an operation mode switch, a CO2 canister, a bellows, a patient inspiratory branch and a patient expiratory branch. The operation mode switch comprises a vent communicating with the patient inspiratory branch, a vent communicating with the patient expiratory branch, a vent communicating with the bellows, and a vent communicating with the CO2 canister. The CO2 canister is positioned below the operation mode switch, so as to collect the water flowing through the operation mode switch.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: June 30, 2020
    Assignee: General Electric Company
    Inventors: Jiancheng Zhang, Huiqun Cheng, Hui Fang
  • Patent number: 10695515
    Abstract: A rodent intubation system includes a main body member including a first port, a second port and a third port. The main body member further includes a magnification lens of approximately 3 to 7× magnification power, which lens is rotatably connected to the main body member so that an animal being intubated may be viewed through the magnification lens during use of the system. An intubation catheter is releasably connected to one port. An inflation bulb is removably connected to another port. Yet another port of the three port system is sized and dimensioned to receive a fiber optic cable there through.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: June 30, 2020
    Inventor: Vahagn Ohanyan
  • Patent number: 10695516
    Abstract: Systems and devices for monitoring, detecting, and removing fluid build-up found at various regions along a tracheal tube of an intubated patient. The fluid management system includes pressure and flow sensors for detecting whether there is fluid at the various regions along the tracheal tube, and a means for drawing out the fluid into collection jars. The system also includes lavage features that is able to rinse different the various regions along a tracheal tube. Also disclosed are respiration insertion devices that either couple to existing tracheal tubes or incorporate tracheal tubing, where the respiration insertion body has channels and ports that contact various regions along the tracheal tube. The combination of the fluid management system and the respiration insertion devices effectively monitor and remove fluid at various locations along a tracheal tube of an intubated patient.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 30, 2020
    Inventors: Jagdish Chaturvedi, Nitesh Kumar Jangir, Nachiket Deval, Ramakrishna Pappu, Raghuveer Rao, Mohammed Sajid Ali, Vimal Kishore Kakani, Sujay Suresh Kumar Shetty
  • Patent number: 10695517
    Abstract: A nasal breathing apparatus with multifunction has two nasal inserts and one tubular chamber. In one embodiment, the first nasal insert forms an airtight barrier inside one nostril for delivering gases. The second nasal insert does not block the other nostril and is for sampling gases. The tubular chamber is in fluid communication with the first nasal insert but not the second nasal insert and has an outlet for discharging and delivering gases and for providing continuous positive airway pressure and ventilation. In another embodiment, both nasal inserts form an airtight barrier in the corresponding nostrils. The first nasal insert is dedicated for delivering gases and the second nasal insert for sampling gases. The tubular chamber is in fluid communication with both nasal inserts and has an outlet for discharging and delivering gases and for providing continuous positive airway pressure and ventilation.
    Type: Grant
    Filed: October 21, 2017
    Date of Patent: June 30, 2020
    Inventor: Baiping Lei
  • Patent number: 10695518
    Abstract: An oral cannula for placement within the oral cavity of a patient for delivery of a treatment gas and for collecting end-tidal carbon dioxide (ETCO2) includes a treatment gas delivery lumen including at least one aperture near a distal end of the treatment gas delivery lumen; an end-tidal CO2 sampling lumen. The cannula also includes a cap having (i) a gas diverter adapted for diverting at least a portion of the treatment gas and (ii) an end-tidal CO2 inlet including flutes and apertures there between that are in communication with the end-tidal CO2 sampling lumen. The oral cannula is adapted for custom bending or has a bend such that the oral cannula is insertable and retainable in a patient's mouth and functional for supplying a treatment gas and sampling gas exhaled by the patient.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: June 30, 2020
    Inventors: Wendy Weaver, Glen Weaver, Peter Stoelzle, Michael Medors, Boon Pheng Tang
  • Patent number: 10695519
    Abstract: A non-invasive ventilation system may include a nasal interface. The nasal interface may include a left outer tube with a left distal end adapted to impinge a left nostril, at least one left opening in the left distal end in pneumatic communication with the left nostril, and a left proximal end of the left outer tube in fluid communication with ambient air. The left proximal end of the left outer tube may curve laterally away from a midline of a face. A right outer tube may be similarly provided. One or more left jet nozzles may direct ventilation gas into the left outer tube, and one or more right jet nozzles may direct ventilation gas into the right outer tube. The jet nozzles may be in fluid communication with the pressurized gas supply.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: June 30, 2020
    Assignee: Breathe Technologies, Inc.
    Inventors: Anthony D. Wondka, Todd Allum, Joseph Cipollone, Gregory Kapust, Darius Eghbal, Joey Aguirre, Anthony Gerber
  • Patent number: 10695520
    Abstract: A portable oxygen concentrator designed for medical use where the sieve beds, adsorbers, are designed to be replaced by a patient. The concentrator is designed so that the beds are at least partially exposed to the outside of the system and can be easily released by a simple user-friendly mechanism. Replacement beds may be installed easily by patients, and all gas seals will function properly after installation.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 30, 2020
    Assignee: Inogen, Inc.
    Inventors: Brenton Taylor, Peter Hansen, Patrick Burgess, Daniel Chin
  • Patent number: 10695521
    Abstract: A patient interface for supplying a flow of breathable gas to the airways of a patient may comprise a heat and moisture exchanger (HME). The HME may be positioned in a flow path of the flow of breathable gas. The HME may absorb heat and moisture from gas exhaled by the patient and the incoming flow of breathable gas to be supplied to the patient's airways may be heated and moisturized by the heat and moisture held in the HME.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: June 30, 2020
    Assignee: ResMed Pty Ltd
    Inventor: Matthew Rolf Harrington
  • Patent number: 10695522
    Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder comprising a housing, a blower structured and configured to produce a flow of air at positive pressure, a flexible connector electrically and physically connected to the blower; and a blower rotation limitation structure configured to reduce rotation of the blower during use. The apparatus may comprise first and second blower suspensions for holding opposite ends of the blower. The blower suspension(s) may be flexible and in tension. The apparatus may comprise one or more connector anchors for anchoring a longitudinal middle section of the flexible connector to another part of the apparatus.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: June 30, 2020
    Assignee: ResMed Pty Ltd
    Inventors: Melanie Lucia Cariola, Barton John Kenyon
  • Patent number: 10695523
    Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: June 30, 2020
    Assignee: Third Pole, Inc.
    Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Ian J. Gillerman
  • Patent number: 10695524
    Abstract: Nebulizer systems, apparatus, and methods are disclosed. The apparatus includes a body, a breathing gas inlet and outlet, and a barrier. The body is sized to be positioned within an adaptor of the nebulizer system. The breathing gas inlet and the breathing gas outlet are at opposite ends of the body. The barrier is coupled to the body. A plurality of holes are formed in the barrier. The plurality of holes open in a direction orthogonal to the breathing gas inlet. The system employs the apparatus in conjunction with a nebulizer and an adaptor. The method includes generating an aerosolized medicament, providing the aerosolized medicament to the adaptor, passing the aerosolized medicament through the barrier of the apparatus, providing a breathing gas to the apparatus, and flowing the aerosolized medicament and the breathing gas through the breathing gas outlet of the apparatus.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: June 30, 2020
    Assignee: VAPOTHERM, INC.
    Inventors: Felino V. Cortez, Jr., William F. Niland
  • Patent number: 10695525
    Abstract: A gas valve is arranged for controlling the flow of medical gas for oxygen therapy in case of spontaneous breathing. An embodiment of the gas valve contains a connection component to connect the gas valve to an external supply such as for example an external supply network for medical gases at a pressure lower than 50 bars. The gas valve may contain a regulating system configured to select and supply a pulsating or continuous flow of medical gas in which the regulating system contains a flow rate regulator to controllable set the flow rate of the continuous flow.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: June 30, 2020
    Assignee: OXYPOINT NV
    Inventors: Dirk Borgonjon, Philip Hendrickx
  • Patent number: 10695526
    Abstract: A respiration device (1) supports cardio-pulmonary resuscitation (CPR) and a method for operating a respiration device (1) supports cardio-pulmonary resuscitation (CPR). The respiration device (1) has a control and regulation unit (7) in order to actuate an expiratory metering unit (3), and an inspiratory metering unit (2) such that, in a first phase, a current value of pressure is increased relative to a first pre-defined value (16) and such that, in a second phase, the current value of the pressure is reduced relative to the first pre-defined value (16).
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: June 30, 2020
    Assignee: DRÄGERWERK AG & CO. KGAA
    Inventors: Judith Löser, Götz Kullik
  • Patent number: 10695527
    Abstract: A gas washout vent, and a patient interface with the gas washout vent, configured to allow patient-exhaled CO2 to flow to an exterior of the plenum chamber to minimise rebreathing of exhaled CO2 by the patient, the gas washout vent including at least one outlet orifice; a diffusing member at least partly covering the outlet orifice; and a blocking member having an air-impermeable material, the blocking member preventing gas exiting from the outlet orifice from flowing straight through the diffusing member.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: June 30, 2020
    Assignee: ResMed Pty Ltd
    Inventor: Muditha Pradeep Dantanarayana
  • Patent number: 10695528
    Abstract: The invention relates to a self-contained device (1) for stimulating slow brain waves, capable of being worn by a person (P), in particular during a period of time when said person is sleeping. The device (1) comprises a supporting element (2), capable of surrounding the head of a person, and on which electrodes (3) are mounted in contact with the person in order to acquire a measurement signal that represents a physiological electrical signal of the person; an acoustic transducer (4) for emitting an acoustic signal (A) stimulating the inner ear of the person; and on-board conditioning and control electronics (5) for, in flexible real time, receiving the measurement signal and controlling the emission of an acoustic signal (A) synchronised with a predefined slow brain wave time pattern.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: June 30, 2020
    Assignee: DREEM
    Inventors: Quentin Soulet De Brugiere, Hugo Mercier, Mathieu Galtier
  • Patent number: 10695529
    Abstract: Methods, systems, and apparatus for changing a cognitive state of a user are disclosed. An example system includes a sensor to gather first electroencephalographic data from the user and an analyzer to determine a first cognitive state of the user based on the first electroencephalographic data and to determine a first binaural beat to present to the user based on the first cognitive state and a second cognitive state. The example system also includes an output to present the first binaural beat to the user. The sensor is to gather second electroencephalographic data from the user exposed to the first binaural beat. The analyzer is to determine a first effectiveness of the first binaural beat to place the user in the second cognitive state, and to determine a second binaural beat to present to the user based on the first cognitive state, the second cognitive state, and the second electroencephalographic data. The output is to present the second binaural beat to the user.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 30, 2020
    Assignee: Intel Corporation
    Inventors: Nishanth Ramaprakash, Sreenidhi Koti
  • Patent number: 10695530
    Abstract: A subject's forehead, and underlying pre-frontal cortex may be cooled by positioning a pre-cooled heat transfer pack on the subject's forehead so that the heat transfer pack is in thermal communication with the subject's forehead, the temperature of the pre-cooled heat transfer pack being below 10° Celsius. Thermal communication between the subject's forehead and the heat transfer pack may be maintained for a period of time sufficient to cool the subject's pre-frontal cortex. Cooling of the pre-frontal cortex may slow the metabolic rate of the subject's pre-frontal cortex and/or induce an onset of sleep for the subject.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: June 30, 2020
    Assignee: Slumber Science LLC
    Inventor: Kevin Surace
  • Patent number: 10695531
    Abstract: An inner tube includes a tubular body made of a first resin and a reinforcing member disposed on an inner side of the tubular body. The reinforcing member is configured of a linear body including a second resin. The inner tube has a first region including a distal portion provided with a distal opening portion and a second region that is disposed to be closer to a proximal side than the first region. The linear body projects inwardly from the inner surface of the tubular body in the first and second regions, and inwardly projects less in the first region than in the second region. In a balloon catheter, guide wire operability is improved and problems which can arise when using a metal reinforcing member are avoided. In a medical elongated body, sliding resistance of a medical device inserted in a lumen can be reduced.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: June 30, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Kenta Suzuki