Patents Issued in June 30, 2020
  • Patent number: 10696592
    Abstract: A blister resistant asphalt impregnating composition comprises asphalt, a linear styrene butadiene block copolymer, a radial styrene butadiene block copolymer, a reactive elastomeric polymer and a fire retardant.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 30, 2020
    Assignee: TREMCO INCORPORATED
    Inventors: Ge Wang, Richard Ogrocki
  • Patent number: 10696593
    Abstract: The present invention relates to a method of preparing a geopolymer using a coal bottom ash. In the method, an alkali activating agent is used in a relatively smaller amount than in a conventional technology so that the mixture of the coal bottom ash and the alkali activating agent does not become a gel state, and a process for radiating a microwave is further provided after curing of a geopolymer specimen in an oven.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: June 30, 2020
    Assignee: HEUNGKUK INDUSTRY CO., LTD.
    Inventor: Kee-Yun Lee
  • Patent number: 10696594
    Abstract: Acoustical tile including a dried base mat of: about 70 to about 90 wt % mineral wool; about 5 to about 15 wt % perlite; 0 to about 10 wt % starch; about 3 to about 10 wt % latex; 0 to about 5 wt % gypsum; and less than 5 wt % water. The dried base mat without including glass fibers and without a laminate layer or coating and without perforations has a NRC of about 0.70 or greater, a density of about 10 pcf to about 12 pcf, and a thickness of about ½ to about 1 inch. The acoustical tile can further include a back coating at a surface weight of about 5 grams per square foot (gsf) to about 40 gsf to the dried base mat, wherein the acoustical tile has the CAC rating of about 30 to about 35.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: June 30, 2020
    Assignee: USG INTERIORS, LLC
    Inventors: Wei Xu, Thomas M. Mayers, Scott C. Bakken
  • Patent number: 10696595
    Abstract: An ultrastable cementitious material with nano-molecular veneer makes a cementitious material by blending 29 wt % to 40 wt % of a magnesium oxide dry powder containing 80 wt % to 98 wt % of magnesium oxide based on a final total weight of the cementitious material, with 14 wt % to 18 wt % of a magnesium chloride dissolved in water and reacting to form a liquid suspension, mixing from 2 to 10 minutes, adding a phosphorus-containing material, and allowing the liquid suspension to react into an amorphous phase cementitious material, wherein a portion of the amorphous phase cementitious material grows a plurality of crystals. The plurality of crystals are encapsulated by the amorphous phase cementitious material forming a nano-molecular veneer. A process to make the ultrastable cementitious material. A tile backer board incorporating the ultrastable cementitious material and a process for making the tile backer board.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: June 30, 2020
    Assignee: MITEK HOLDINGS, INC.
    Inventors: James A. Wambaugh, Brett Rochner
  • Patent number: 10696596
    Abstract: A method for producing a dielectric ceramic includes: shaping mixed powdery particles including a cordierite material (2MgO.2Al2O3.5SiO2) and a low-temperature-sintering material including Al, Si and Sr, the Si being partially vitrified; and firing the resultant shaped body. The method includes the step of wet-pulverizing the low-temperature-sintering material together with at least the cordierite material to prepare mixed powder particles having a median diameter D50 less than 1 ?m; and, in a process until a time of the preparation of the mixed powder particles, the low-temperature-sintering material undergoes no step of wet-pulverizing only the low-temperature-sintering material, and drying the resultant pulverized material.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 30, 2020
    Assignee: HITACHI METALS, LTD.
    Inventor: Hirokazu Nakajima
  • Patent number: 10696597
    Abstract: The present disclosure relates to a precursor solution for the preparation of a ceramic of the BZT-?BXT type, where X is selected from Ca, Sn, Mn, and Nb, and ? is a molar fraction selected in the range between 0.10 and 0.90, said solution comprising: 1) at least one barium precursor compound; 2) a precursor compound selected from the group consisting of at least one calcium compound, at least one tin compound, at least one manganese compound, and at least one niobium compound; 3) at least one anhydrous precursor compound of zirconium; 4) at least one anhydrous precursor compound of titanium; 5) a solvent selected from the group consisting of a polyol and mixtures of a polyol and a secondary solvent selected from the group consisting of alcohols, carboxylic acids, esters, ketones, ethers, and mixtures thereof; and 6) a chelating agent, as well as method of using the same.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 30, 2020
    Assignee: STMicroelectronics S.R.L.
    Inventors: Angela Cimmino, Giovanna Salzillo, Valeria Casuscelli, Andrea Di Matteo
  • Patent number: 10696598
    Abstract: To provide a dielectric porcelain composition and an electronic component that demonstrate ferroelectricity. A dielectric porcelain composition that is characterized by having a perovskite-type oxynitride as a principal component and by including a polycrystalline body that demonstrates ferroelectricity.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 30, 2020
    Assignees: TDK CORPORATION, NATIONAL UNIVERSITY CORPORATION HOLLAIDO UNIVERSITY
    Inventors: Kumiko Yamazaki, Yuki Nagamine, Takeshi Shibahara, Shinichi Kikkawa, Yuji Masubuchi
  • Patent number: 10696599
    Abstract: There is provided a shape memory ceramic structure including an aggregate population of crystalline particles. Each crystalline particle in the population, of crystalline particles comprises a shape memory ceramic particle material. Each crystalline particle in the population of crystalline particles has a crystalline particle extent that is between about 0.5 microns and about fifty microns. At least a portion of the population of crystalline particles has a crystalline structure that is either oligocrystalline or monocrystalline.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: June 30, 2020
    Assignees: Massachusetts Institute of Technology, Nanyang Technological University
    Inventors: Zehui Du, Hang Yu, Christopher A. Schuh, Chee Lip Gan
  • Patent number: 10696600
    Abstract: A method for producing a component includes a) providing at least two preforms each made of a carbon composite material, b) joining the at least two preforms at least at one respective connecting surface to form a composite, in which a joining compound is introduced between the joining surfaces of the preforms and then cured and the joining compound contains silicon carbide and at least one polymer adhesive, and c) siliconizing the composite to form the component. A component, such as an optical component produced thereby, is also provided.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: June 30, 2020
    Assignee: SGL Carbon SE
    Inventors: Peter Polster, Andreas Kienzle, Thomas Putz, Albin Von Ganski, Blasius Hell, Alfred Haeusler
  • Patent number: 10696601
    Abstract: Compounds are generally provided, which may be particularly used to form a layer in a coating system. In one embodiment, the compound may have the formula: AxBbLn1?x?bHf1?t?dTitDdMO6, where: A is Al, Ga, In, Sc, Y, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Fe, Cr, Co, Mn, Bi, or a mixture thereof; x is about 0.01 to about 0.99; b is 0 to about 0.5, with 1?x?b being 0 to about 0.99 such that Ln is present in the compound; Ln is a rare earth or a mixture thereof that is different than A; t is 0 to about 0.99; D is Zr, Ce, Ge, Si, or a mixture thereof; d is 0 to about 0.5; the sum of t and d is less than 1 such that Hf is present in the compound; and M is Ta, Nb, or a mixture thereof.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: June 30, 2020
    Assignee: General Electric Company
    Inventor: Glen Harold Kirby
  • Patent number: 10696602
    Abstract: Embodiments of the invention relate to a method of making a mineral product. The method includes contacting a carboxylic acid and an inorganic mineral compound sufficient to form a solution, reacting the solution over a period of time sufficient to provide a mineral chelated compound, transferring the mineral chelated compound to one or more molds prior to the compound substantially solidifying and reducing the size of the mineral chelated compound sufficient to provide a rapidly soluble mineral chelated product.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: June 30, 2020
    Assignee: Ralco Nutrition, Inc.
    Inventors: Brian Jon Knochenmus, Jon Kent Knochenmus, Richard Dale Lamb, Myrra Arlene Lamb
  • Patent number: 10696603
    Abstract: A treated biochar comprising a porous carbonaceous particle that has been treated and mixed with a media containing a mineral solubilizing microorganism, whereby the porous carbonaceous particle after mixing has retained the mineral solubilizing microorganism.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: June 30, 2020
    Assignee: Carbon Technology Holdings, LLC
    Inventors: Richard W. Belcher, Han Suk Kim, Brian Buege, Ronald A. Sills
  • Patent number: 10696604
    Abstract: Novel granular fertilizers and methods of making those fertilizers are provided. The method utilized involves recycling streams, including one that provides water having dissolved solids therein, with that water being used during the mixing and granulation process. This method results in a low-moisture, hard, substantially spherical granule, which can include any number of macronutrients and/or micronutrients. Advantageously, the granular fertilizer can be applied to the soil around plants to supply those plants with the necessary nutrients.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: June 30, 2020
    Assignee: Produquímica Indústria e Comércio S.A.
    Inventors: André Cotrim, Ricardo Oliveira, Michel Castellani, Ithamar Prada
  • Patent number: 10696605
    Abstract: The present invention relates to uses of vanadium to convert aldehydes and ozonides into their respective acids and/or ketones. More particularly, this invention relates to the oxidative work-ups following ozonolysis using vanadium during ozonolysis, and using vanadium to oxidize aldehydes in general. The invention also relates to methods comprising the ozonolysis of oleyl alcohol in the presence of either an acid or an alcohol.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: June 30, 2020
    Assignee: P2 SCIENCE, INC.
    Inventors: Patrick Foley, Yonghua Yang, Tania Salam
  • Patent number: 10696606
    Abstract: A method for converting an alcohol to a hydrocarbon fraction reduced in gaseous hydrocarbon content, the method comprising: (i) contacting said alcohol with a metal-loaded zeolite catalyst under conditions suitable for converting said alcohol to a first hydrocarbon fraction containing liquid hydrocarbons having at least five carbon atoms along with gaseous hydrocarbons having less than five carbon atoms, wherein said metal-loaded zeolite catalyst is catalytically active for converting said alcohol to said first hydrocarbon fraction; and (ii) selectively removing said gaseous hydrocarbons from the first hydrocarbon fraction and contacting said gaseous hydrocarbons with a metal-loaded zeolite catalyst under conditions suitable for converting said gaseous hydrocarbons into liquid hydrocarbons having at least five carbon atoms to produce a second hydrocarbon fraction reduced in gaseous hydrocarbon content, wherein the metal-loaded zeolite catalyst in steps (i) and (ii) are the same or different.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: June 30, 2020
    Assignee: UT-Battelle, LLC
    Inventors: Chaitanya K. Narula, Brian H. Davison, Zhenglong Li
  • Patent number: 10696607
    Abstract: Disclosed is a process for producing C2+ hydrocarbons, and systems for implementing the process, that includes providing a reactant feed that includes methane and an oxygen containing gas to a first reaction zone, wherein the temperature of the reactant feed is less than 700° C. contacting the reactant feed with a first catalyst capable of catalyzing an oxidative coupling of methane reaction (OCM) to produce a first product stream that includes C2+ hydrocarbons and heat, and contacting the first product stream with a second catalyst capable of catalyzing an OCM reaction to produce a second product stream that includes C2+ hydrocarbons, wherein the produced heat is at least partially used to heat the first product stream prior to or during contact with the second catalyst, wherein the amount of C2+ hydrocarbons in the second product stream is greater than the amount of C2+ hydrocarbons in the first product stream.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: June 30, 2020
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Wugeng Liang, Sagar Sarsani, David West, James Lowrey, Aghaddin Mamedov, Istvan Lengyel
  • Patent number: 10696608
    Abstract: In a process for producing paraxylene, a hydrocarbon feedstock comprising benzene and/or toluene is contacted with an alkylating reagent comprising methanol and/or dimethyl ether in an alkylation reaction zone under alkylation conditions in the presence of an alkylation catalyst to produce an alkylated product comprising xylenes. The alkylation catalyst comprises a molecular sieve having a Constraint Index ?5, and the alkylation conditions comprise a temperature less than 500° C. At least part of the alkylated product is supplied to a paraxylene recovery unit to recover paraxylene and produce a paraxylene-depleted stream, which is then contacted with a xylene isomerization catalyst under conditions effective to isomerize xylenes in the paraxylene-depleted stream and produce an isomerized stream having a higher concentration of paraxylene than the paraxylene-depleted stream. At least part of the isomerized stream is then recycled to the paraxylene recovery unit to recover the paraxylene therein.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: June 30, 2020
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Todd E. Detjen, Tan-Jen Chen, Brett T. Loveless, Robert G. Tinger
  • Patent number: 10696609
    Abstract: A method of producing p-xylene, the method comprising the steps of converting the C9+ aromatic hydrocarbons and the hydrogen gas in the presence of a dealkylation catalyst to produce a dealkylation effluent, separating the dealkylation effluent to produce a carbon-nine (C9) aromatics stream, a xylene stream, and a toluene stream, separating the p-xylenes from the xylene stream in the p-xylene separation unit to produce a p-xylene product and a p-xylene depleted stream, converting the m-xylene and o-xylene in the p-xylene depleted stream in the isomerization unit to produce an isomerization effluent, reacting the C9 aromatics stream and the hydrogen stream in the presence of a transalkylation catalyst in the transalkylation reactor to produce a transalkylation effluent, separating the C6 to C9+ aromatic hydrocarbons in the isomerization effluent and the transalkylation effluent in the splitter column to produce a benzene recycle, a toluene recycle, a xylene recycle and a C9+ recycle.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: June 30, 2020
    Assignee: Saudi Arabian Oil Company
    Inventors: Qi Xu, Raed Abudawoud
  • Patent number: 10696610
    Abstract: A procedure for hydrogenation of alpha dimethyl styrene dimer that is scalable, economical, and safe is provided. These processes routinely provide greater than a 98% yield and require no purification step. The methods of producing hydrogenated alpha dimethyl styrene dimer comprising adding to a reactor under nitrogen a catalyst comprising Ru/C or Rh/C and an alpha dimethyl styrene dimer to form a catalyst and alpha dimethyl styrene dimer reaction mixture. The reaction mixture is then heated under pressure until hydrogenation of the alpha dimethyl styrene dimer is complete. To recover the hydrogenated alpha dimethyl styrene dimer, the reaction mixture is filtered through a celite bed under nitrogen.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: June 30, 2020
    Assignee: VALVOLINE LICENSING AND INTELLECTUAL PROPERTY LLC
    Inventors: Rajkumar Rajule, Jesse Dambacher
  • Patent number: 10696611
    Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: June 30, 2020
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Yung Hyup Joo, Song Seok Shin, Byoung Young Woo, Heung Soo Baek, Yong Deog Hong, Hong-Ju Shin, Yeon Su Jeong, Jon Hwan Lee
  • Patent number: 10696612
    Abstract: An amorphous molecular material having stilbene and benzyl group substituents at both side of stilbene has fluorescent characteristics.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: June 30, 2020
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Woong Kim, Ka Hoe Ku, Hee Yeon Park
  • Patent number: 10696613
    Abstract: Disclosed are processes for the dechlorination of haloethanes comprising reacting in the gaseous phase a haloethane and reducing agent such as an alkene, an alkane, hydrogen or combinations of two or more of these, in the presence of a silicon-based catalyst.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: June 30, 2020
    Assignee: HONEYWELL INTERNATIONAL INC.
    Inventors: Haridasan K. Nair, Rajiv Ratna Singh, Mark Makar
  • Patent number: 10696614
    Abstract: Provided herein are methods of CO2 reduction to methanol or CO using a Cu2O catalyst.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: June 30, 2020
    Assignee: UChicago Argonne, LLC
    Inventors: Yimin Wu, Tijana Rajh, Ian McNulty, Yuzi Liu
  • Patent number: 10696615
    Abstract: A method for treating cancer can include administering a therapeutically effective amount of a compound of formula (Ia): or pharmaceutically acceptable salts or solvates thereof, wherein R1a, R1b, R1c, R1d, R2, and R3 are as defined, and A----B is selected from CH?CH, CH?CH(CH2)pCH2, or CH2—CH2(CH2)pCH2, and where p is 1 or 2.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: June 30, 2020
    Assignee: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan Tran, Rujee Kyokajee Duke
  • Patent number: 10696616
    Abstract: It is intended to provide a method capable of lowering a formic acid concentration in acetic acid product by a simple approach. The method for producing acetic acid according to the present invention comprises at least one step selected from a step that satisfies the following operating condition (i) and a step that satisfies the following operating condition (ii) in an acetic acid production process, and controlling an oxygen concentration in an embodiment satisfying at least one selected from the following (iii) and (iv) for one or more processes: (i) operating conditions involving a hydrogen partial pressure of less than 500 kPa (absolute pressure), a carbon dioxide partial pressure of less than 70 kPa (absolute pressure), and an operating temperature of more than 150° C.; (ii) operating conditions involving a hydrogen partial pressure of 5 kPa or less (absolute pressure), a carbon dioxide partial pressure of less than 20 kPa (absolute pressure), and an operating temperature of more than 100° C.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: June 30, 2020
    Assignee: DAICEL CORPORATION
    Inventor: Masahiko Shimizu
  • Patent number: 10696617
    Abstract: Provided is a method for the alcoholysis of an amide. The method comprises subjecting an amide-containing compound to alcoholysis under alkaline conditions using an epoxy compound as an accelerant of alcoholysis, the method comprising: mixing the amide-containing compound, the epoxy compound, a pH adjuster and a solvent to form an alkaline reaction system, the pH of the alkaline reaction system being 7.5-9.5; reacting the alkaline reaction system at 50° C. ˜150° C. to subject the amide-containing compound to alcoholysis.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: June 30, 2020
    Assignee: ASYMCHEM LABORATORIES (TIANJIN) CO., LTD
    Inventors: Jiangping Lu, Qinglan Pei, Jinquan Yu, Enxuan Zhang
  • Patent number: 10696618
    Abstract: Polymerization inhibitor compositions are provided. The polymerization inhibitor compositions may include at least one hydroxylamine of a nitroxide and at least one phenylenediamine. Methods of inhibiting the unwanted polymerization of monomers are also provided. The methods include adding the presently disclosed polymerization inhibitor compositions to a fluid containing the monomers. The monomers may be ethylenically unsaturated monomers, such as acrylic acid, methacrylic acid, acrylonitrile, methacrylonitrile, acrolein, methacrolein, acrylate, methacrylate, acrylamide, methacrylamide, vinyl acetate, butadiene, ethylene, propylene, and styrene.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: June 30, 2020
    Assignee: ECOLAB USA INC.
    Inventor: David Youdong Tong
  • Patent number: 10696619
    Abstract: A method for preparing dialkyl carbonate is provided. The preparation method includes the following steps. An alcohol compound, carbon dioxide and a catalyst are mixed to form a mixing solution. Organic acid is added to the mixing solution to carry out a synthesis reaction of dialkyl carbonate. The alcohol compound includes methanol, ethanol, propanol or butanol. The catalyst includes cerium oxide, zirconium oxide, titanium oxide, lanthanum oxide or a combination thereof. The organic acid includes formic acid, acetic acid, propionic acid, butyric acid, valeric acid or a combination thereof.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: June 30, 2020
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yen-Chih Chen, Man-Yin Lo, Hsi-Yen Hsu
  • Patent number: 10696620
    Abstract: Disclosed herein are compounds for use as antimicrobial agents, having a structure of formula (I):
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: June 30, 2020
    Assignee: Boulos & Cooper Pharmaceuticals Pty Ltd
    Inventors: Allan James McKinley, Thomas V. Riley, Nigel Lengkeek, Scott Stewart, Ramiz Boulos
  • Patent number: 10696621
    Abstract: The present invention relates to a novel chiral phase-transfer catalyst, and a method for preparing an alpha-amino acid by using the same. According to the present invention, an alpha-amino acid of high optical purity could be synthesized in a high yield under an easy industrially applicable reaction condition by using a novel cinchona alkaloid compound as a chiral phase-transfer catalyst, and thus the present invention can be used as a key technique of the asymmetric alpha-amino acid synthesis and preparation field.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: June 30, 2020
    Inventors: Kee Pyung Nahm, Yeon Ji Lee, Bae Geun Lim, Seung A Woo, Ji Inn Oh, Won Gyoung Son
  • Patent number: 10696622
    Abstract: Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1-alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N-methyl,1alkoxyethylformamide.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: June 30, 2020
    Assignee: Eastman Chemical Company
    Inventors: Kim Dumoleijn, Kristof Moonen, Alexis Henricot, Cai Xing Simon Han
  • Patent number: 10696623
    Abstract: The present invention relates to a novel phenolic acid derivative compound with whitening and antioxidant activities and use thereof. The phenolic acid derivative compound is a compound represented by Formula 1, which is described in the specification, an isomer thereof or a salt thereof. The compound of the present invention has skin whitening activity to inhibit tyrosinase, thus being suitable for use in a pharmaceutical composition or cosmetic product for skin whitening. In addition, the compound of the present invention is suitable for the prevention or treatment of oxidation-derived skin abnormality or disease such as skin aging due to its antioxidant activity.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: June 30, 2020
    Assignee: DAEBONG LS, LTD
    Inventors: Jin Oh Park, Ji Won Lee, Jae Young Lee, Hye Ja Lee, Bo kyung Kwon
  • Patent number: 10696624
    Abstract: Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: June 30, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Xiang-Qun Xie, Abdulrahman Almehizia, Peng Yang
  • Patent number: 10696625
    Abstract: A process for preparing polyaryl ethers in which a polycondensation of the monomer building blocks is carried out using microwave irradiation leads to thermoplastic molding compositions having improved color properties.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: June 30, 2020
    Assignee: BASF SE
    Inventors: Frauke Thrun, Joaquim Henrique Teles, Jun Gao
  • Patent number: 10696626
    Abstract: A photoinitiator is provided which incorporates a camphorquinone photoinitiator moiety.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: June 30, 2020
    Assignee: Coloplast A/S
    Inventors: Charlotte Juel Fristrup, Petr Sehnal, Bahar Bingol
  • Patent number: 10696627
    Abstract: A process for producing a pentaerythritol mercaptocarboxylic acid ester of the present invention includes: a step of reacting pentaerythritol with a mercaptocarboxylic acid, in which an absorbance of a 5 wt % aqueous solution of the pentaerythritol at a wavelength of 270 nm, which is measured using a quartz cell having an optical path length of 50 mm, is 0.07 or less.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 30, 2020
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Shigetoshi Kuma, Masayuki Furuya, Takeshi Nishimura
  • Patent number: 10696628
    Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: June 30, 2020
    Assignee: TPAT IP LLC
    Inventor: Thomas Daly
  • Patent number: 10696629
    Abstract: The present invention provides a crystalline form of dextral oxiracetam. The crystalline form has a diffraction peak when a diffraction angle, 2?, is 17.12±0.2°, 18.88±0.2°, 19.24±0.2°, 21.18±0.2°, 24.88±0.2°. The crystalline form having oxiracetam can promote synthesis of phosphorylcholine and phosphoethanolamine, boosts cerebral metabolism, has a stimulating function on a specific central nervous pathway through a blood-brain barrier, improves the intelligence and memory, has an obvious effect on a memory dysfunction, and has special biologic activity in the field of sedation and the antiepileptic field. The method for preparing the crystalline form is simple and is suitable for industrial production.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: June 30, 2020
    Assignee: CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED
    Inventor: Lei Ye
  • Patent number: 10696630
    Abstract: Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect. The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: June 30, 2020
    Assignee: Kyorin Pharmaceuticals Co., Ltd.
    Inventors: Hiroyasu Takahashi, Yoshifumi Saito, Kosuke Tsuda, Mitsuhito Shibasaki, Kohei Ohata
  • Patent number: 10696631
    Abstract: The present invention is directed to a compound of Formula I or Formula III or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: wherein the definitions R1-R13 and L1-L4 are provided in the disclosure, and wherein R14 is a peptide. The compounds of Formula I may be covalently bonded to a peptide via a linker to provide a compound of Formula III and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 30, 2020
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Xiaoyuan Chen, Orit Jacobson Weiss
  • Patent number: 10696632
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 30, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Patent number: 10696633
    Abstract: A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 30, 2020
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Hermut Wehlan, Kai Rossen, Guenter Billen
  • Patent number: 10696634
    Abstract: The present invention relates to compounds I wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and intermediates for compounds I.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: June 30, 2020
    Assignee: BASF SE
    Inventors: Wassilios Grammenos, Christian Winter, Bernd Mueller, Antje Wolf, Ana Escribano Cuesta, Erica Cambeis, Jan Klaas Lohmann, Thomas Grote, Manuel Kretschmer, Nadine Riediger, Ian Robert Craig, Christine Wiebe, Violeta Terteryan-Seiser, Andreas Koch, Marcus Fehr, Tobias Mentzel
  • Patent number: 10696635
    Abstract: A class of mono-protected 3-amino-2-hydroxypyridine (MPAHP) ligands that enable the meta-C—H arylation of anilines, phenols, phenylacetic acids, and biologically relevant heterocyclic compounds using norbornene as a transient mediator is disclosed, such as in the formation of a reaction product of Formula IA: The applicability of this meta-arylation methodology in the pharmaceutical industry is illustrated for heteroaryl substrates and heteroaryl iodide coupling partners, a feat made possible by using the MPAHP ligand. The enabling nature of MPAHP ligands to achieve other meta-C—H functionalization processes is also illustrated by the development of a meta-C—H amination reaction and a meta-C—H alkynylation reaction.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: June 30, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventor: Jin-Quan Yu
  • Patent number: 10696636
    Abstract: The present invention provides compound of formula (XVII), wherein P is hydroxyl protecting group; R2 and R3 are independently lower alkyl or R2 and R3 can be alkyl and joined to form a 5-, 6- or 7-membered ring; R4 is lower alkyl, and process for its preparation.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 30, 2020
    Assignee: Lupin Limited
    Inventors: Girij Pal Singh, Dhananjai Shrivastava, Harishchandra Sambhaji Jadhav, Pramod Sudhakar Utekar, Digambar Yashwant Salunke
  • Patent number: 10696637
    Abstract: A compound represented by the general formula, or a salt thereof, has exceptional CXCL10 inhibitory activity and is useful as a treatment agent for the prevention and/or treatment, etc., of diseases involving overproduction of CXCL10. In the formula: R1 is a C1-6 alkyl group, etc.; R2 is a hydrogen atom, etc.; R3 is a halogen atom, etc.; Z1, Z2, and Z3 are CH, etc.; X1 is CONH, etc.; ring A is a phenyl group, etc.; R4 is a halogen atom, etc.; and m is an integer of 0-5.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 30, 2020
    Assignees: FUJIFILM Corporation, FUJIFILM Toyama Chemical Co., Ltd.
    Inventors: Tadashi Tanaka, Masataka Fujino, Kentaro Furuya
  • Patent number: 10696638
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is —C(?Z)—, wherein Z is N—CN, NH, NR4, NCOR4, NCONR4R5, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, —NH2, —CN, —OH, —O-alkyl, —O-aryl, —COOH, —COOR4, —CONHR4, —CONHCH2-aryl, —CONR4CH2-aryl, —NHCOR4, halogen, halogened alkyl, -alkyl-OR4, -alkyl-ONO2, alkyl-ONO2, —OCOOR4, —O(C?O)-aryl, —CHR4OH, —CH2OH, —CH2O(C?O)-aryl, —CH2O(C?O)—R4, —CHR4O(C?O)-aryl, —CHR4O(C?O)—R4, unsaturated carboxylic ester, substituted alkynyl, —NHSO2R4, —SO2R4, —SO2NHR4, or —SO2NR4R5, or Y and J bond together to form a carbocylic or aromatic ring, wherein R4 and R5 are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR6R7, —S(O)0-2-(alkyl-NR6R7).
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: June 30, 2020
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chih-Hung Chen, Yi-Hsun Chen, Jui-Wen Huang, Kuo-Kuei Huang, Chih-Peng Liu, Chrong-Shiong Hwang
  • Patent number: 10696639
    Abstract: The present invention is directed to compounds of Formula (I), pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 30, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Tanweer Khan, Elizabeth Smith, Peter Williams, Catherine Wiscount, Brian McKittrick, John McCauley
  • Patent number: 10696640
    Abstract: Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R1 is a C1 to C8 fluoroalkyl group; R2 and R3 are each independently a C1 to C12 alkyl group or the like; Y1 to Y4 are each independently a hydrogen atom, a halogen atom, or the like; and X? is a monovalent anion. A compound of the general formula (3): R4—S—R1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R4—S—Z wherein R4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: June 30, 2020
    Assignee: Kumiai Chemical Industry Co., Ltd.
    Inventors: Kentaro Kawazoe, Kotaro Yoshioka
  • Patent number: 10696641
    Abstract: Disclosed are novel bis(aminophenylphenol) ligands and transition metal compounds derived therefrom. Also disclosed are methods of making the ligands and transition metal compounds.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: June 30, 2020
    Assignee: Univation Technologies, LLC
    Inventors: Catherine Anne Faler, Kevin P. Ramirez