Abstract: The present disclosure relates to methods for treating type 1 diabetes (T1D) using a glucagon receptor blocking agent. More specifically, the present disclosure relates to methods for treating T1D using substantially lower doses of insulin supplementation, or even in the absence of insulin supplementation, using antigen binding and antagonizing proteins, e.g., fully human antibodies that specifically bind to and antagonize the function of the human glucagon receptor.

Abstract: The present invention relates to humanized monoclonal antibodies or antigen-binding fragments thereof that specifically bind to human CD40 receptor and induce CD40 signaling independent of Fey mediated CD40 receptor crosslinking. The antibodies of the present invention bind to a CD40 epitope that overlaps with the epitope of the CD40 ligand and can activate human APCs. The present invention also provides for compositions comprising said antibodies and uses for the antibodies and compositions in the treatment of patients suffering from cancer.

Abstract: Provided is a fusion protein comprising an agonist for CD40 and an agonist for OX40. Compositions comprising the fusion protein and methods of use are also provided.

Abstract: The invention provides methods and compositions for modulating the immune response in a subject, such as decreasing the activity of CD30+ T regulatory cells and increasing the ratio of CD8+ T cells to CD30+ T regulatory cells, through administration of antibody drug-conjugates that bind to CD30. The invention also provides articles of manufacture or kits comprising said antibody drug-conjugates that bind to CD30 for modulating the immune response.

Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.

Abstract: Described herein is a method of sensitizing a cancer in a subject and methods of treating, slowing the progression of, reducing the severity of, preventing the recurrence of, and/or reducing the recurrence likelihood of a cancer in a subject. The invention further provides for a method of preventing the recurrence of and/or reducing the recurrence likelihood of a cancer in a subject who has been treated with a cancer therapy.

Abstract: The present invention relates to a method and a pharmaceutical composition for treating an HCC negative for HBV/HCV, comprising administering a subject in need thereof an therapeutically effective amount of an inhibitory agent to control the genetic alteration of lipid homeostasis associated genes, including CD36 amplification and ABCG4 deletion. According to the present invention, medicines targeting the lipid metabolism pathways are developed to treat HCC patients with CD36 amplification and/or ABCG4 deletion.

Abstract: The present disclosure provides methods for treating multiple myeloma (such as refractory multiple myeloma or relapsed and refractory multiple myeloma) in an individual who received at least two prior therapies for multiple myeloma. The methods comprise administering to the individual an anti-CD38 antibody, pomalidomide, and dexamethasone. Also provided are methods of improving renal impairment in an individual having multiple myeloma.

Abstract: The disclosure provides antigen binding proteins useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.

Abstract: The invention provides antibodies that specifically bind to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies, as well as polynucleotides, vectors, host cells, and methods useful for production thereof. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, optionally in combination with another anti-cancer agent. Still further provided are methods and kits for treating or preventing gastrointestinal disease in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine.

Abstract: The present disclosure generally relate to novel chimeric antigen receptors (CARs) that bind an engulfment receptor expressed on the surface of a phagocytic cell and activate the endogenous phagocytic signaling pathway. Also disclosed are compositions and methods useful for producing such CARs, nucleic acids encoding same, phagocytic cells that have been modified to include a targeted effector activity directed towards a cell of interest such as, e.g., a cancer cell, as well as for modifying a cell and/or for the treatment of various health disorders such as cancer, including solid tumor and hematologic malignancy.

Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.

Abstract: The present describes monoclonal antibody to MUC1*.

Abstract: The present invention concerns fixed dosing of HER antibodies, such as Pertuzumab.

Abstract: The present invention relates to a composition for producing an extracellular matrix from a eukaryotic cell, the composition comprising a polypeptide or compound capable of specifically binding to a microtubule associated serine/threonine kinase family member 4 (MAST4) protein or a fragment thereof or a polynucleotide, polypeptide or compound capable of specifically binding to a nucleic acid coding for the MAST4 protein or a fragment thereof, and a composition for promoting chondrogenesis, comprising the same composition.

Abstract: This application generally relates to the field of methods, systems and compositions for addressing diseases associated with apoptotic cell death, including autoimmune diseases and inflammatory diseases, and more particularly to such methods, systems and compositions that use antibodies having binding specificity to PKM2.

Abstract: The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for anti-body-based methods, such as a lateral flow immunoassay and other point of care devices.

Abstract: The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.

Abstract: The present invention provides a method for controlling colocalization of two or more proteins in a cell. The method comprises expressing the proteins, scaffold RNA molecules having binding motifs for the proteins, and a trigger RNA molecule in the cell. In the presence of the trigger RNA molecule, a scaffold may be assembled (ON) by the scaffold RNA molecules via hybridization such that the proteins may be colocalized; or disassembled (OFF) such that the proteins may be separated and not colocalized. The proteins may provide a biological activity when colocalized or not colocalized.

Abstract: A crosslinked polymeric network is disclosed. The crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Abstract: The present invention includes a rubber composition containing a modified diene polymer having a group represented by Formula (I) below and a group represented by Formula (II) below, and silica; and a modified diene polymer and a production method thereof. In Formula (I), X1 represents at least one selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, X3 represents a hydrocarbon group, n3 represents from 0 to 4, and X2 represents at least one selected from the group consisting of sulfone-based protecting groups, carbamate-based protecting groups, and —(R—O)n4—H. In Formula (II), R1-1 represents a divalent hydrocarbon group, R1-2 and R1-3 each independently represent a monovalent hydrocarbon group, m1 is from 1 to 3, m2 is from 0 to 2, m1+m2 is 3, and R1-4 represents a hydrogen atom or a hydrocarbon group.

Abstract: Provided are a chemical polymerization initiator including (a) a thiourea compound, (b) a peroxyester, (c) a divalent copper compound, and (d) an aryl borate compound, an adhesive composition, an adhesive composition kit, a dental material, and a dental material kit each using the chemical polymerization initiator, and a method of storing the adhesive composition.

Abstract: Methods for preparing supported chromium catalysts containing a chromium (III) compound and an activator-support are disclosed. These supported chromium catalysts can be used in catalyst compositions for the polymerization of olefins to produce polymers having low levels of long chain branching, and with greater sensitivity to the presence of hydrogen during polymerization.

Abstract: The invention is generally related to a process for producing a relatively high molecular weight poly(methacrylic acid) (“PMAA”) in a water-based system. The process of the invention comprises polymerization of from about 1% to about 20% by weight of methacrylic acid in water or a water-based system in the presence of thiol compound and an azo radical initiator under controlled reaction and process conditions. A process of the invention can be easily scaled up into the pilot scale for producing large quantities of high molecular weight PMAAs. The invention is also related to high molecular weight poly(methacrylic acid)s obtained according to a process of the invention.

Abstract: A polymeric article comprises an elastomeric layer comprising cured synthetic polyisoprene particles that comprise a Ziegler-Natta catalyzed polyisoprene.

Abstract: A method of preparing a catalyst support comprising contacting an acid-soluble titanium-containing compound with an acid to form a first mixture; contacting the first mixture with an alkali metal silicate to form a hydrogel which has a silica content of from about 18 wt. % to about 35 wt. % based on the total weight of the hydrogel; contacting the hydrogel with an alkaline solution to form an aged hydrogel; washing the aged hydrogel to form a washed hydrogel; and drying the washed hydrogel to produce a titanium-containing-silica support wherein the support has a pore volume equal to or greater than about 1.4 cm3/g.

Abstract: The present invention relates to homopolypropylene resin for non-woven fabric, and according to the present invention, by optimizing tacticity to 80% to 90%, having narrow molecular weight distribution of 2.4 or less, and fulfilling melt index of 20 g/10 min to 30 g/10 min, melting point of 145° C. or less, and residual stress rate of 0.05% or less, thereby optimizing modulus, high strength non-woven fabric that is softer than the existing products, and is not easily torn due to high tenacity, can be prepared.

Abstract: The present disclosure relates to a polymer including a unit represented by Chemical Formula 1 and a unit represented by Chemical Formula 2, a coating composition including the polymer, and an organic light emitting device formed using the same.

Abstract: An ethylene-(meth)acrylic acid copolymer has a polydispersity index (PDI) in a range from 3.5 to 8.0, and has a melt flow index (MFI) measured at 190° C. and 2.16 kg in a range from 350 g/10 min to 1800 g/10 min A water-dispersive composition includes the ethylene (meth)acrylic acid copolymer, a neutralizing agent and an aqueous medium.

Abstract: An acrylic rubber has a residual calcium content of 60 wt ppm or less and a polymer pH of 7.0 or less, and preferably has a carboxyl group.

Abstract: Provided is a water repellent composition which does not use a fluorine-containing monomer, especially a fluoroalkyl group-containing monomer. A water repellent composition which contains (1) (a) a polymer which has a repeating unit derived from an amide group-containing monomer that is represented by formula: (wherein R1 represents an organic residue having an ethylenically unsaturated polymerizable group; R2 represents a hydrocarbon group having 7-30 carbon atoms; and R3 represents a hydrocarbon group having 1-5 carbon atoms) in an amount of 2-100% by weight relative to the polymer, and (2) a liquid medium.

Abstract: Provided is a rubber-containing graft polymer capable of reducing wet heat aging of a shaped article while improving the strength developing property of a thermoplastic resin. In the rubber-containing graft polymer of the present invention, a content of components having a weight-average molecular weight of 800,000 or more is 1% by mass or more with respect to an organic solvent-soluble fraction (100% by mass) of the rubber-containing graft polymer, and a phosphorus content in the rubber-containing graft polymer is 3 to 30 mmol/kg.

Abstract: A vinylamide block copolymer kinetic hydrate inhibitor and a preparation method thereof are disclosed. The vinylamide block copolymer kinetic hydrate inhibitor has a structural formula as shown in formula I. Through reverse atom transfer radical polymerization, under an anaerobic operating condition, with vinylcaprolactam and acrylamide as monomers, dimethylformamide as a solvent, azobisisobutyronitrile as an initiator, and a transition metal complex composed of a catalyst anhydrous copper chloride and a ligand 2,2?-bipyridine as a catalytic system, the method has achieved to catalyze a controllable free radical solution polymerization to obtain a poly(vinylcaprolactam-acrylamide) block copolymer kinetic hydrate inhibitor. The synthesized kinetic hydrate inhibitor has a controllable molecular weight, a narrow molecular weight distribution, and a controllable synthesis process, and exhibits an excellent inhibitory effect.

Abstract: A block polymer comprising a first block and a second block is provided. The first block contains aromatic ?-mono-olefin units, and the second block contains both 1,3-diene units and mono-olefin units.

Abstract: An amine-functionalized, crosslinked porous copolymer can be synthesized by linking 1,4-benzenediamine and pyrrole with p-formaldehyde in the presence of concentrated hydrochloric acid catalyst. The polymer is permanently microporous, with a BET surface area of 250 to 350 m2/g. Due to the high concentration of polar amines within its backbone, the polymer exhibits a CO2 uptake of 17.5 to 30 cm3/g at 298 K and 1 bar, but demonstrated a remarkably high selectivity for CO2 over N2 at 298 K. Dynamic breakthrough experiments indicate that this material is an effective adsorbent for selectively separating CO2 from a dry and wet gas mixture containing N2 for over 45 cycles without significant loss of performance. Furthermore, the polymer can be regenerated at room temperature after each cycle by a simple N2 flow.

Abstract: Curable cyanoacrylate compositions are reported that comprise cyanoacrylate and a thermoplastic polyurethane (TPU) components. Such compositions are toughened cyanoacrylate compositions exhibiting long term viscosity stability when stored for prolonged periods at room temperature (25° C.). TPU components are reported having structural units in which at least one of the structural units has the formula —O—R1—O—Ar—O—R2—O—, wherein Ar is a C6-C20 aromatic group with at least one aromatic ring; R1 is a C2-C10 alkyl group; and R2 is a C2-C10 alkyl group. The thermoplastic polyurethane (TPU) component may be present in the curable cyanoacrylate composition from about 1 wt % to about 40 wt %, for example from about 2 wt % to about 30 wt %, such from about 3 wt % to about 20 wt %, suitably from about 5 wt % to about 10 wt %, based on the total weight of the composition.

Abstract: A method of producing a polyether polyol includes reacting a low molecular weight initiator with one or more monomers in the presence of a polymerization catalyst, and the low molecular weight initiator has a nominal hydroxyl functionality of at least 2. The one or more monomers includes at least one selected from propylene oxide and butylene oxide. The polymerization catalyst is a Lewis acid catalyst having the general formula M(R1)1(R2)1(R3)1(R4)0 or 1, whereas M is boron, aluminum, indium, bismuth or erbium, R1, R2, R3, and R4 are each independent, R1 includes a fluoroalkyl-substituted phenyl group, R2 includes a fluoroalkyl-substituted phenyl group or a fluoro/chloro-substituted phenyl group, R3 includes a fluoroalkyl-substituted phenyl group or a fluoro/chloro-substituted phenyl group, and optional R4 includes a functional group or functional polymer group, R1 being different from at least one of R2 and R3.

Abstract: The present invention generally relates to polyurethanes and polyurethane nanocomposites having improved mechanical, rheological, and thermal properties over ordinarily produced polyurethanes and polyurethane nanocomposites. Such polyurethanes and polyurethane nanocomposites include very small amounts of a small chain diol, such as glycerol, and more specifically, between 0.01 and 4 weight percent of the small chain diol, based on the total polymer composition.

Abstract: Compositions suitable for production of polyurethane foams, comprising at least one OH-functional compound (OHC) obtainable by the partial or complete hydrogenation of ketone-aldehyde resins, wherein the OH-functional compound contains at least one structural element of the formula (1a) and optionally of the formulae (1b) and/or (1c), with R=aromatic with 6-14 carbon atoms, (cyclo)aliphatic with 1-12 carbon atoms, R1=H, CH2OH, R2=H, or a radical of the formula —(CH2—CH(R?)O—)y—H where R? is hydrogen, methyl, ethyl or phenyl and y=1 to 50, k=2 to 15, preferably 3 to 12, more preferably 4 to 11, m=0 to 13, preferably 0 to 9, l=0 to 2, where the sum of k+1+m is from 5 to 15, preferably from 5 to 12, and k>m, are described.

Abstract: The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs). The present invention also relates to: (a) malleable, repairable, and reprogrammable shape memory polymers having HUBs, (b) reversible or degradable (e.g., via hydrolysis or aminolysis) linear, branched or network polymers having HUBs, and (c) to precursors for incorporation of HUBs into these polymers. The HUB technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating the HUBs can be used in a wide variety of applications including plastics, coatings, adhesives, biomedical applications, such as drug delivery systems and tissue engineering, environmentally compatible packaging materials, and 4D printing applications.

Abstract: A method for deblocking a blocked isocyanate is described herein. The method includes contacting a blocked isocyanate and a halide ion source under conditions effective to provide a deblocked isocyanate. A method of making a polyurethane is also disclosed. The method of making a polyurethane includes combining a blocked isocyanate, a polyol, and a halide ion source in the presence of solvent and under conditions effective to provide the polyurethane.

Abstract: A glycidyl amine epoxy resin(s) and a process for production of glycidyl amine epoxy resin(s) are disclosed. The glycidyl amine epoxy resin(s) is/are free from Bisphenol A (BPA) and Bisphenol F (BPF) and are based on AMES negative amine precursors.

Abstract: The resin composition is a resin composition for a fiber-reinforced composite material including: a main agent containing an epoxy resin (A) and an acrylate compound (B) having 4 or more acryloyl groups in a molecule thereof; and a curing agent containing an amine compound (C) represented by the following general formula (1), the resin composition being a two-component curable resin composition including the main agent and the curing agent at a mass ratio in the range of from 90:10 to 65:35, wherein the main agent has a viscosity at 25° C. measured with an E-type viscometer of 20,000 mPa·s or less, and wherein the curing agent has a viscosity at 25° C. measured with the E-type viscometer of 800 mPa·s or less: X—(CH2NH2)n ??(1) where X represents an n-valent organic group having 1 to 16 carbon atoms, and “n” represents 2 or 3.

Abstract: The present invention provides efficient processes for preparing brush polymers. In general, the process comprises three distinct reaction steps utilizing two separate catalysts. In the first step, the initiating compound comprising norbornene is contacted with a silane in the presence of a catalyst, thereby forming a silated intermediate. This silated intermediate is then contacted with a monomer in the presence of a catalyst via Group Transfer Polymerization (GTP). The resulting compound from GTP is contacted with a ring opening metathesis polymerization (ROMP) catalyst to prepare the brush polymer. Surprisingly, the brush polymers obtained from the above process are accessed in an efficient and rapid GTP methodology as compared to prior methods.

Abstract: Provided are integrated processes for the conversion of ethylene oxide to polypropiolactone. System for the production of polypropiolactone are also provided.

Abstract: The present invention relates to a tape comprising a composition comprising a copolyester comprising polymeric units derived from ethylene glycol and terephthalic acid or a diester thereof and >0.50 and <5.00 wt % of polymeric units with regard to the total weight of the polyester derived from an oligomeric dihydroxy compound having a number average molecular weight of >500 g/mol and <5000 g/mol. Such tape has an improved tensile-impact strength and a reduced proneness to splitting during weaving.

Abstract: Disclosed are polymer compounds wherein the main polymer chain is a polyester and the pendants are polyalkylpiperidine. The compounds of the invention, either alone or mixed with other known agents, are useful as stabilisers of polymers, especially polyolefins.

Abstract: The present invention provides an aliphatic polycarbonate that can be thermally decomposed (dewaxed) at a relatively low temperature. The aliphatic polycarbonate comprises a constituent unit represented by formula (1): wherein R1, R2, and R3 are identical or different, and each represent a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 15 carbon atoms, or a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; R4 represents a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, or a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; and n is an integer of 0 to 3.

Abstract: A method for the manufacture of polyether ketone ketone (PEKK), including: providing a 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex; purifying said 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex; reacting said 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex with at least one difunctional aromatic acyl chloride in a reaction solvent and optional additional Lewis acid to obtain a product mixture including a PEKK-Lewis acid complex; and decomplexing the PEKK-Lewis acid complex to obtain a PEKK polymer. Also, a composition including at least 40 wt. % of 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex and an anhydrous aprotic solvent or solvent mixture, wherein the composition includes less than 1 wt. %, preferably less than 0.5 wt. % and in particular less than 0.1 wt. % of molecules comprising xanthydrol groups. And, the use of the composition for the manufacture of polyether ketone ketone.