Abstract: Devices, system and methods for deforming body channels are disclosed herein. At least some embodiments described may be used to deform a body channel so as to decrease or prevent the normal intrachannel flow of material within the body channel. Such deformation may be used to treat such maladies as Gastroesophageal Reflux Disease.

Abstract: A catheter assembly comprises a catheter having a distal end and a longitudinal axis, a stent disposed about the distal end of the catheter, and a stent protector. The stent protector has a stent covering portion disposed about the stent and a catheter engagement portion that removably engages the stent protector to the catheter assembly. The stent covering portion is disposed about the stent without substantially engaging the stent.

Abstract: A removable blood clot filter includes a number of locator members and anchor members disposed radially and extending angularly downward from a hub. The locator members include a number of linear portions having distinct axes configured to place a tip portion approximately parallel to the walls of a blood vessel when implanted to apply sufficient force to the vessel walls to position the filter near the vessel centerline. The anchor members each include a hook configured to penetrate the vessel wall to prevent longitudinal movement due to blood flow. The hooks may have a cross section sized to allow for a larger radius of curvature under strain so that the filter can be removed without damaging the vessel wall.

Abstract: A valve to perform lung volume reduction procedures is described. The valve is formed of a braided structure that is adapted for endoscopic insertion in a bronchial passage of a patient's lung. The braided structure has a proximal end and a distal end and is covered with a non porous coating adapted to prevent flow of air into the. A constricted portion of the braided structure is used to prevent flow of air through a central lumen of the structure, and to define at least one funnel shaped portion. The funnel shaped portion blocks the flow of air towards the constriction, i.e. towards the core of the lung. At least one hole is formed in the braided structure to permit flow of mucus from the distal end to the proximal end, to be expelled out of the lungs.

Abstract: The present disclosure relates to a system for manufacturing of vascular patches in the form pre-operative surgical planning prototypes providing optimized patient specific 3-D patch geometries. The present disclosure relates more particularly to a patch generation device for manufacturing of vascular patches in the form pre-operative surgical planning prototypes providing optimized patient-specific patch geometries, said patch generation device comprising a processing unit effectuating processing of the optimized patient-specific patch geometries.

Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

Abstract: A stent for use in a medical procedure having opposing sets of curved apices, where the curved section of one set of apices has a radius of curvature that is greater than the curved section of the other set of apices. One or more such stents may be attached to a graft material for use in endovascular treatment of, for example, aneurysm, thoracic dissection, or other body vessel condition.

Abstract: A bifurcated endovascular prosthesis that includes a tubular main body having a diameter, a proximal end, a distal end, an internal lumen extending from the proximal end to the distal end, an anterior side, and a posterior side. The anterior and posterior sides are opposite each other circumferentially around the internal lumen. The prosthesis also includes a first limb that extends from the distal end of the tubular main body along the anterior side of the main body. The first limb has a diameter less than the diameter of the tubular main body and having a proximal end and a distal end. The prosthesis also includes a fenestration adjacent to the proximal end of the first limb. The fenestration extends from the proximal end of the first limb to the posterior side of the tubular main body. The prosthesis also includes a second limb that extends within the internal lumen from the fenestration toward the proximal end of the tubular main body.

Abstract: An apparatus is configured to be implanted within a biological structure. The apparatus includes a plurality of magnetic elements, an absorbable component, and a non-absorbable component. The plurality of magnetic elements are configured to transition the biological structure between an occluded state and an opened state. The plurality of magnetic elements are biased to encourage the biological structure toward the occluded state. The absorbable component includes a therapeutic substance. The absorbable component is configured to temporarily couple the plurality of magnetic elements with the biological structure when the apparatus is initially implanted within the biological structure.

Abstract: Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.

Abstract: A variety of configurations of implant management devices are provided. The configurations provide different combinations of features for maintaining a location of an implant with respect to the device and managing filaments of the implant. One exemplary embodiment of a device includes a generally rectangular-shaped body having an implantable body retainer, an opening disposed a distance apart from the retainer and configured to receive a ligament graft therein, and a fold extending across the body and intersecting the opening. Folding one end of the body towards a bottom surface of the body along the fold can form a filament loop engaging region to hold in tension a filament loop extending from the implant. Additional filament(s) associated with the implant can be managed by various filament retention features. Methods for preparing a ligament graft for implantation by relying upon indicia formed on a surface of the device body are also provided.

Abstract: The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and/or in using the device, donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.

Abstract: The disclosure describes a breast implant device product that mimics the natural pectoral fat of the breast and is characterized by an incomplete pyramid with isosceles triangular base and wedge-shaped edges and sloping faces that meet at acute angles with variable degree located medially, laterally, and on the top and a footprint characterized by a semicircular lower portion and an oval paraboloid upper portion and a center of gravity located closer to the footprint than to the profile, the said footprint is advantageously converging and moving towards the underlying surface as the chest wall with a method of manufacturing and a method of use of the said implant including a breast pyramid sizing system.

Abstract: A method of treating a lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern of the light beam, delivering the treatment pattern to the lens of a patient's eye to create a plurality of cuts in the lens in the form of the treatment pattern to break the lens up into a plurality of pieces, and removing the lens pieces from the patient's eye. The lens pieces can then be mechanically removed. The light beam can be used to create larger segmenting cuts into the lens, as well as smaller softening cuts that soften the lens for easier removal.

Abstract: An intraocular lens system is presented that comprises an electro-active lens comprising multiple independently controllable zones or pixels, and a controller capable of being remotely programmed.

Abstract: A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.

Abstract: The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member having an upstream portion and a downstream portion. The device further includes an extension member coupled to the fixation frame and extending radially outward therefrom. The extension member includes a plurality of wires, at least a portion of which include an inner core surrounded by an outer material. The wires include a plurality of recesses extending through at least a portion of the thickness of the outer material, and a therapeutic agent in the recesses for delivery to the anatomy when the prosthetic heart valve device is positioned at a native annulus.

Abstract: Stented prosthetic heart valves including a stent frame having a plurality of stent frame support structures collectively defining an interior surface, an exterior surface and a plurality of cells. The stented prosthetic heart valve further including a valve structure including valve leaflets disposed within and secured to the stent frame and defining a margin of attachment. The stented prosthetic heart valve including one or both of an outer paravalvular leakage prevention wrap and an inner skirt for supporting the valve leaflets. In various embodiments, the outer wrap is positioned entirely on one side of the margin of attachment. In embodiments including an inner skirt, the outer wrap and the inner skirt are on opposite sides of the margin of attachment such that the inner skirt and the outer wrap do not overlap. In other embodiments, the outer wrap includes a plurality of zones having varying thickness.

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

Abstract: A system for deploying a device to a distal location across a diseased vessel, comprising a sheath comprising an expandable distal portion comprising a porous wall defining a lumen there-through, the distal portion having a collapsed configuration, wherein the sheath has a first cross-sectional outer diameter and a first lumen inner diameter, and an expanded configuration, wherein the sheath has a second cross-sectional outer diameter and a second lumen inner diameter; wherein in the collapsed configuration, the sheath is configured to be advanced across at least a portion of the diseased vessel to a position adjacent the distal location and wherein said system comprises a removable expansion retention member configured to retain the expandable sheath in the collapsed configuration.

Abstract: A dynamic, adjustable annuloplasty ring sizer can include an adjustable ring replica, which can be adjusted through a range of sizes corresponding to available prosthetic annuloplasty repair ring sizes. Actuation of an adjustment trigger on a handle portion of the ring sizer can displace tension wires that extend through a malleable shaft and through a plurality of articulating segments that form the ring replica. Displacement of the tension wires causes flexion of the joints between adjacent articulating segments, thereby reducing the overall size of the ring replica. Releasing the tension wires can allow an elastic extension wire to act on the ring replica, enlarging the ring replica to its maximum, at-rest size. In this manner, the appropriate size of annuloplasty ring prosthesis can be determined with a single device, without requiring a plurality of static ring sizers that require individual insertion and placement for the conventional trial-and-error sizing methods.

Abstract: An inflatable penile prosthetic system includes a pump adapted for attachment to a reservoir; a penile prosthetic assembly including an inflatable bladder having a distal end sized for placement within a glans penis, a base connected to the inflatable bladder, with base including an interior channel extending an entire length of the base from a hole formed in a proximal end of the base to the inflatable bladder, and a tubing port coupled to an exterior surface of the base, with the tubing port adapted for attachment to the pump, a plug sized for insertion into the hole; and a push rod.

Abstract: The present application is generally directed to an expandable sleeve component of an implantable penile prosthesis, to a prosthesis containing the sleeve, and to related methods of preparation and use. More specifically, the present application is directed to an implantable penile prosthesis having a cylindrical polymeric (e.g., extruded, molded, etc.) sleeve for controlling cylinder expansion upon placement of the prosthesis within a corpus cavemosum and expansion during use.

Abstract: A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.

Abstract: Techniques, mixtures, mixing and delivery kits, and improved delivery instruments for implantation of micronized allograft tissue over a microfractured defect. Allograft cartilage tissue is delivered over a cartilage defect that has been debrided and microfractured, without the need for a periosteal covering or separate type of patch sewn over the top. The allograft tissue may be any micronized cartilage particulates obtained by various methods, for example, cartilage delivered in its native form, dehydrated via lyophilization, “freeze-dried,” dehydrated via desiccation, or dehydrated by any other method.

Abstract: An implant for an artificial hip joint and, more specifically, a dual mobility acetabular cup assembly for an artificial hip joint is configured to have improved locking mechanism between a liner and a shell and improved resistance to micromotion and to guide the liner into the shell with proper orientation by providing stable liner-shell fastening structure to the acetabular cup assembly.

Abstract: An orthopaedic knee prosthesis includes a femoral component having a condyle surface. The condyle surface is defined by one or more radii of curvatures, which are controlled to reduce or delay the onset of anterior translation of the femoral component relative to a tibial bearing.

Abstract: An implant configured for fusing a first bone segment and a second bone segment during an operative procedure and constructed in accordance to one example of the present disclosure includes an implant body, a first bone interfacing portion and a second bone interfacing portion. The implant body can extend longitudinally between an insertion end and an opposite end. The first bone interfacing portion can be provided on the implant body and be configured to be implanted relative to the first bone segment. The second bone interfacing portion can be provided on the implant body and be configured to be implanted relative to the second bone segment. The first and second bone interfacing portions can be inserted dorsally into the first and second bone segments, respectively.

Abstract: An expandable, intervertebral spacer includes a top component and a base component in engagement with the top component, the base component defining at least one channel for receiving a hardening material, and placement of the hardening material within the channel causes the top component to move between a first position in which the top component is a first distance from the base component and a second position in which the top component is a second distance from the base component, the second distance being greater than the first distance. The hardening material can be removed from the channel by a flexible coring tool, and the top component forced toward the base component to collapse the spacer.

Abstract: An expandable implant is made via a central strut having a pivotable arm on each end. The implant can be inserted into a disc space either horizontally or vertically with the arms in a closed position and then (if inserted horizontally) optionally rotated up into place. The arms are then pivoted out, thereby increasing the foot print of a horizontally inserted implant. The expanded implant can be locked in place through the use of an additional insert or ratchet that fits between the arms and locks the arms in place.

Abstract: A beam acts as an implantable spinal support structure. The beam is generally cylindrical in form with two semi-cylindrical shells defining a cylindrical contour of the beam and with a web passing through a central axis of the beam and joining midpoints of the two shells together. The shells preferably have threads on an outer surface thereof to engage bone within a cylindrical hole passing through two adjacent vertebrae spanning a disk space, for support of the vertebrae such as for fusion thereof together. One end of the beam can be tapered to maximize structural support for the vertebrae. This tapered end can be provided as a separate extension removably attachable to other portions of the beam in one embodiment. A method for implantation is also disclosed where the beam is implanted at an angle to the spinal axis and intersecting a disk space between adjacent vertebrae.

Abstract: A spinal implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body defines a cavity. A plate is connectable with the implant body via a coupling member adjacent the cavity and is translatable relative thereto. The coupling member has a portion including a frangible torque limit. The plate defines at least one opening oriented to implant a fastener with tissue. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A surgical implant and a method for the making the surgical implant is provided. The surgical implant includes various granules incorporated into an upper surface and a lower surface of a body portion thereof. The granules can be pressed into the upper surface and the lower surface via physical force using at least one mold portion. The physical force applied by the at least one mold portion can deform and/or extrude the upper surface and the lower surface to impregnate these surfaces with the granules. The granules can provide the implant with bioresorbable and/or mechanically-reinforced properties.

Abstract: Illustrative methods and systems for customizing a pre-manufactured acetabular shell to a specific patient are described herein. An illustrative method can include positioning a provisional shell at an acetabulum of the patient, the provisional shell having a plurality of selectable openings. The method further including marking, based on the assessing of the bone, a patient-matched hole location on a provisional liner that corresponds to one of the plurality of selectable openings in the provisional shell. With the provisional liner marked, the method can further include removing the provisional liner from the provisional shell and positioning the provisional liner in the pre-manufactured acetabular shell that is to be implanted in the patient. Using the provisional liner as a guide, the method can include forming a hole in the acetabular shell corresponding to the marked patient-matched hole location on the provisional liner.

Abstract: A system and method for allowing any surgeon, including those surgeons who perform a fewer number of a replacement procedure as compared to a more experienced surgeon who performs a greater number of procedures, to provide an improved likelihood of a favorable outcome approaching, if not exceeding, a likelihood of a favorable outcome as performed by a very experienced surgeon with the replacement procedure.

Abstract: A bone fusion method, system and device for insertion between bones that are to be fused together and/or in place of one or more of the bones, such as, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable tabs having a central rib. The bone fusion device includes one or more support channels configured to receive an insertion instrument that is then secured to the bone fusion device via a coupling mechanism. As a result, the coupled device is able to be securely positioned between vertebrae using the insertion instrument with minimal risk of slippage.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: A bone fusion method, system and device for insertion between bones that are to be fused together and/or in place of one or more of the bones, such as, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable tabs having a central rib. The bone fusion device includes one or more support channels configured to receive an insertion instrument that is then secured to the bone fusion device via a coupling mechanism. As a result, the coupled device is able to be securely positioned between vertebrae using the insertion instrument with minimal risk of slippage.

Abstract: The present invention relates to a an attachment device for attaching a prosthesis to a bone, comprising: a base plate having an extension in an xy-plane; a first holder for holding a first abutment; a second holder for holding a second abutment; a locking plate attached to the base plate to restrict movement of the holders in a z-direction away from the base plate. The locking plate is configured to allow rotation of the first and second holder around a z-axis perpendicular to the xy-plane. The locking plate and the base plate is configured to allow movement of the first holder along the x-direction and to prevent movement the y-direction and to prevent movement of the second holder in the x- and y-direction.

Abstract: Disclosed herein are systems and methods for sensor systems. In one embodiment, a system may include an implantable component and an external component. The implantable component may comprise a housing and an electrode array configured to receive a plurality of biopotential signals. The housing may comprise a wireless power receiver and a wireless data transmitter to transmit representations of the biopotential signals. The external component may comprise a wireless data receiver configured to receive the plurality of digital representations of the biopotential signals and a wireless power transmitter configured to provide power to the internal component. A shielding component may separate the wireless power transmitter from the wireless data receiver. An interface may be configured to communicate with a prosthesis and configured to cause the prosthesis to implement a voluntary motion based on the plurality of digital presentations of the biopotential signals.

Abstract: An upper extremity post-operative residual limb support assembly includes an upper frame; a lower frame adjustably coupled to the upper frame; a liner coupled to the upper frame and the lower frame, the liner including: a first liner portion configured to be positioned adjacent the upper frame and extend at least partially about an arm of a user; and a second liner portion configured to be positioned adjacent the lower frame, the second liner portion including a closed end configured to receive a distal end of a residual portion of the arm.

Abstract: A liner is arranged for use in prosthetic and orthopedic devices. The liner defines first and second end portions, and inner and outer surfaces. The liner includes an inner layer having a frictional component and forms at least part of the periphery of the inner liner surface. The inner layer defines a plurality of apertures. A porous element is in communication with the inner liner surface and is connected to the inner layer such that the apertures permit a transfer of air from the inner surface to the porous element. A base layer adjoins the porous element and extends between the first and second end portions of the liner.

Abstract: A dynamic support system includes a control system for controlling inflation and deflation of at least one actuator having an inlet connectable to the a control unit of the dynamic support system. The control unit may be in communication with a sensor and may control inflation and deflation of the at least one actuator in response to information provided by the sensor.

Abstract: A vacuum suspension system includes a pump mechanism operatively connectable to a prosthetic socket. The pump mechanism has a first member and a second member. An inflatable bladder is disposed between the first and second members. A fluid chamber is located between the first and second members and fluidly separate from the inflatable bladder. Inflation of the inflatable bladder mechanically separates the first and second parts to create a vacuum pressure in the fluid chamber.

Abstract: The present invention provides devices and methods for fabricating and deploying an implantable device within the body. The invention is particularly suitable for delivering and deploying a stent, graft or stent graft device within a vessel or tubular structure within the body, particularly here the implant site involves two or more interconnecting vessels. The delivery and deployment system utilizes a plurality of strings which are releasably attached to the luminal ends of the implantable device.

Abstract: A medical lumen-expansion balloon may include a generally cylindrical central body between first and second body end portions, a low-profile unexpanded first state and a radially-expanded second state, wherein the first body end portion is constrained by fiber material such that it will not expand longitudinally and circumferentially beyond a predetermined size, and the central body is constrained by fiber material so as to be circumferentially substantially noncompliant, but is longitudinally compliant, such that it will elongate with increased volume but will not substantially radially expand.

Abstract: A hand support device and method for somatosensory input to the palm comprises a support portion and an attachment portion. The support portion forms a rounded surface that supports a hand of a user. The attachment portion attaches to a structure. The device activates purposeful motor movement with accurate motor control for users with Dyspraxia when employed in conjunction with evidence-based developmental pedagogy in high stimulating tasks such as music education per the Rancer Method (Kupferstein & Walsh, 2015). In one example, the hand support device attaches to a piano and clamps to the keyslip allowing the user to rest their hand while playing the piano. In another example, the hand support device is adapted to attach to a surface of a laptop or desk with a base surface that is disposed above the laptop, allowing the user to rest their hand while typing on the keyboard.

Abstract: Methods, devices and systems for delivering a device assembly into a gastric or other space within the body, allowing the device to expand to occupy volume within the gastric space and, after an effective period of time, delivering a substance or stimulus to begin breakdown of the expanded device so that it may release from the body.

Abstract: A gastrointestinal device for implanting within a patient's gastrointestinal tract, the device having a central axis and a first expandable portion comprising a hollow tubular braided structure of wire and having a first cylinder extending parallel to the central axis, the first cylinder having a length and a first face; a neck portion extending from the first face of the first expandable portion parallel to the central axis, the neck portion having a first end, a second end, a wall extending between the first end and second end, and a diameter sized to fit within a pylorus; and a second expandable portion comprising a hollow tubular braided structure of wire and having a second cylinder extending parallel to the central axis, the second cylinder having a second face located at the proximal end of the second cylinder and oriented transverse to the central axis.

Abstract: An ankle/foot orthosis with a foot part, which has a sole for receiving a foot, and with a shin part which, when fitted in place, bears on the frontal aspect of a shin and is connected to the foot part via a medially extending spring, wherein the spring, behind an ankle area, forms a hinge area that allows a movement of the shin part relative to the foot part in the anterior-posterior direction.