Abstract: A water-based liquid cosmetic comprising: sodium polyaspartate; at least one brilliant powder selected from the group consisting of a glass powder coated with a metal or a metal oxide, an aluminum powder, and a resin film powder coated with a metal; a water-soluble dispersant; and at least one metal oxide selected from the group consisting of yellow iron oxide, red iron oxide, black iron oxide, titanium dioxide, titanium oxynitride, and Prussian blue.

Abstract: An oil-in-water type emulsion cosmetic exhibits a high-level sunscreen effect and has a low viscosity and a high stability and is easy to use. The oil-in-water type emulsion cosmetic includes (A) an agar microgel, (B) one or more kinds of powders selected from (b1) a clay mineral powder and (b2) a highly oil-absorbing spherical powder, (C) a polyoxyethylene-hardened castor oil having an HLB value of 10-17; (D) an oil-soluble UV absorber, (E) 0.01-0.13 mass % of an (acrylate/alkyl acrylate (C10-30)) cross polymer, and (F) 0-0.5 mass % of a UV scattering agent, and is characterized in that the viscosity at 25° C. is not higher than 10,000 mPa·s.

Abstract: The invention relates to toothpaste tablets comprising a binding agent, an abrasive agent, a whitening agent, a polishing agent, a sulfate free surfactant, natural gum, sweetener, and a flavor agent.

Abstract: A first subject of the present disclosure is a special oxidant preparation for oxidative coloring of keratinous fibers, more particularly human hair, included in a cosmetic carrier (A) hydrogen peroxide and (B) at least one acid from the group of sulfuric acid, hydrochloric acid, phosphoric acid, lactic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, oxalic acid, ascorbic acid, phytic acid, gluconic acid, nitric acid, malonic acid, acetic acid and-or C3-C22 alkane carboxylic acids, wherein the oxidant preparation has a pH value of from about 0.5 to about 3.0. Additional subjects of the present disclosure are methods for oxidative color changing of human hair in which this special oxidant preparation is used.

Abstract: Aqueous dispersions which exhibit properties required of an aqueous dispersion and achieve stability and homogeneity include inorganic particle groups dispersed in an aggregation state in water. In this dispersion, when the total mole number ratio represented by moles of surface hydrophilic groups of the inorganic particle groups moles of surface hydrophobic groups is within a prescribed lower limit value or more depending on the aggregating properties of inorganic particles, the inorganic particle groups contain self-micelle-like aggregates and hydrophobic-rich aggregates.

Abstract: The present invention relates to a process for the elongation and/or densification of fibers, on a keratin material, characterized in that it employs a composition, especially a cosmetic composition, in particular a makeup composition, comprising at least: —one volatile hydrocarbon-based oil, —particles of at least one polymer surface-stabilized with a stabilizer, and —a hydrophobic film-forming polymer, chosen from hydrocarbon-based block copolymers, hydrocarbon-based resins, and mixtures thereof.

Abstract: A hair-colouring composition comprising an estolide ester derived from ricinoleic acid and direct dyes.

Abstract: The present invention relates to a composition for dyeing keratin fibres comprising, in a cosmetically acceptable medium: —one or more direct dyes of triarylmethane structure, —one or more amino silicones and —one or more surfactants. The invention also relates to a process for dyeing keratin fibres using said composition and also to a use for dyeing keratin fibres.

Abstract: The present invention relates to a non-dyeing composition comprising: (i) one or more cationic acrylic copolymers comprising at least the units obtained from the following monomers: a) monomer derived from acrylic or methacrylic esters or amides and comprising at least one cationic group, and b) alkyl acrylate or methacrylate monomer, the alkyl radical comprising from 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, better still 1 to 10 carbon atoms and preferentially 2 to 6 carbon atoms. and (ii) one or more conditioning agents chosen from functionalized silicones, cationic polymers and cationic surfactants, and mixtures thereof.

Abstract: The present invention relates to a cosmetic composition, especially for conditioning the hair, comprising: one or more fatty-chain sulfate, sulfonate or carboxylic anionic surfactants, one or more solid fatty alcohols, and one or more solid fatty esters. The invention also relates to a cosmetic treatment process, especially for conditioning keratin materials, in particular sensitized hair, using said composition.

Abstract: A subject of the invention is a process for dyeing keratin fibres such as the hair, using at least one cationic direct dye bearing a disulfide, thiol or protected-thiol function and comprising at least one ammonium group bearing an aliphatic chain (I). Another subject of the invention is the use i) of at least one cationic direct dye bearing a disulfide, thiol or protected-thiol function (I) combined with ii) steam and/or a heating iron for straightening keratin fibres, for dyeing keratin fibres, and novel cationic direct dyes bearing a disulfide, thiol or protected-thiol function (I), and also a cosmetic composition comprising same. The process used and the use of the thiol, protected-thiol or disulfide dyes combined with steam makes it possible in particular to obtain a long-lasting colouration with a care valency on the keratin fibres.

Abstract: The present invention discloses a hair care and nourishing cosmetic composite, which relates to a cosmetic product for the aid in the treatment of hair loss, baldness, alopecia, weakness of the threads among others, which is characterized by combining the auxina tricógena with caffeine, differentiating the product for female and male users, being formulas for each gender as follows: Formula for the female audience: 70% of Auxina Tricógena 15%, 30% of Caffeine 3%, Formula for Male use: 70% caffeine 3%, 30% Tricogen Auxin, in any of the compositions, a quantity of ml of Hydroalcoholic Solution is applied according to the need of each person.

Abstract: The present invention relates to a composition for inhibiting micro-organisms, as well as related processes, formulations, concentrates and uses. The composition comprises at least 30 wt.-% compound X, wherein compound X is according to Formula (I): wherein R is a saturated or unsaturated hydrocarbon chain having seven or nine carbon atoms, or a mixture thereof.

Abstract: An injectable hyaluronic acid composition including a hyaluronic acid; a local anesthetic selected from the group of amide and ester type local anesthetics or a combination thereof; and an ascorbic acid derivative in an amount which prevents or reduces the effect on the viscosity and/or elastic modulus G? of the composition caused by the local anesthetic upon sterilization by heat. Further, the medical and non-medical, such as cosmetic, use of such a composition, and to a method of manufacturing such a composition.

Abstract: The antioxidant compositions of various embodiments comprise methyl carboxymethylphenylaminocarboxy propylphosphonate, also known as MCAP, (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, also known as rosmarinic acid, and 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[?-L-rhamnopyranosyl-(1?6)-?-D-glucopyranosyloxy]-4H-chromen-4-one, also known as rutin wherein the antioxidant composition demonstrate a synergistic effect compared with the MCAP, the rosmarinic acid, or the rutin alone. The methods include treating skin or hair damaged by reactive oxygen species, preventing skin or hair damage, and treating aged skin.

Abstract: The subject of the present disclosure is a method for coloring of human hair, comprising the following steps in the specified sequence A) Mixing a first component (K1) with a second component (K2) to produce a first mixture (M1), B) Mixing the mixture (M1) with a third component (K3) to produce a second mixture (M2), C) Application of the mixture (M2) on the hair, D) Allowing the mixture (M2) to take effect for a period of from about 30 seconds to about 45 minutes, E) Rinsing the mixture (M2) from the hair, wherein the first component (K1) is a dye preparation comprising at least one oxidation dye precursor, and the second component (K2) is a color diluent which does not contain any oxidation dye precursors or oxidants and—the third component (K3) is an oxidant preparation comprising at least one oxidant.

Abstract: This invention relates to anhydrous polymer film compositions containing various polysaccharide ingredients useful for numerous applications. The invention relates to anhydrous liquid compositions that, when dried down, form a film that can release desired ingredients in a controlled and extended-use way. The films can be erodible, partially soluble or completely soluble when used in conjunction with water or water vapor.

Abstract: Disclosed is a stable whitening dentifrice composition including a whitening complex, wherein the whitening complex comprises (a) a whitening agent and (b) a cross-linked vinyl lactam based polymer. The stable whitening dentifrice composition further includes a blue pigment having a blue to blue-violet color with a hue angle in the CIELAB system ranging from 200 degrees to 320 degrees, a zinc salt, and an orally acceptable vehicle. Methods of using the composition to whiten tooth surfaces are also disclosed.

Abstract: The invention relates to siloxane elastomers, which can be obtained by the reaction of A one or more oligomeric organohydrogensiloxanes having at least two SiH-bearing siloxane units per molecule with B one or more oligomeric divinylsilanes and the use of C platinum(0)-1,2-divinyl-1,1,3,3-tetramethyldisiloxane as a hydrosilylation catalyst.

Abstract: Methods and compositions for preventing or reducing hair frizz. The compositions are anhydrous and comprise at least one polysiloxane fluid component selected from an amodimethicon e and a polysiloxane component comprising a plurality of hindered amine side chains. The compositions also comprise a silicone-compatible, volatile liquid carrier component, preferably selected from a low molecular weight, volatile siloxy component; a hydrocarbon; and an alcohol. The compositions are preferably serums or fluids, and are suitable for use in a conditioner, as a “leave-in” hair care product, or as a touch-up hair care product suitable for use during the day.

Abstract: A cream to be applied topically to the hair and scalp in order to infuse moisture. The present invention effectuates this capability through a mixture of a raw material blend, in a chemical composition' proportion that brings about effective results. The prevailing ingredients in the finished product are pumpkin seed oil (Cucurbita pepo), rosehip seed oil (Rosa canina L.), mango butter (Mangifera indica), and citric acid.

Abstract: The present specification discloses a composition for caring for skin damage caused by fine dust, wherein the composition includes a fermented tea extract as an active ingredient and adjusts the expression level of at least one selected from the following group of genes which are present in skin cells and have expression levels that are affected by fine dust to normal levels, said group consisting of: IL-1B (NM_000576), IL-36G (NM_019618), S100A7 (NM_002963), LCE3D (NM_032563), PTGS2 (NM_000963) and XDH (NM_000379). Damage to skin cells can be cared for by using the composition for caring for skin damage caused by fine dust to return gene expression levels, which change due to fine dust, to normal levels.

Abstract: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.

Abstract: The invention relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer (1) of polymer nanofibres workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer (1) of polymer nanofibres a drug and/or other physiologically active substance are deposited in a releasable manner.

Abstract: The present disclosure generally relates to compositions that inhibit matrix metalloproteinases (MMPs). These compositions may be particularly useful in treating periodontal disease and skin wrinkling. The compositions can be prepared as a topical formulation, ointment, mouthwash, or packaged in a syringe.

Abstract: The present invention relates to a composition, preferably an aqueous pharmaceutical solution, comprising a water-soluble polymer derived from cellulose and hyaluronic acid, preferably comprising carboxymethylcellulose and hyaluronic acid. More specifically, the invention relates to a composition, preferably an aqueous pharmaceutical solution, comprising 0.0001%-5% hyaluronic acid and 0.005%-2% carboxymethylcellulose. The invention also relates to the use of said composition, preferably an aqueous pharmaceutical solution, in the manufacturing of a medicament for the treatment of lesions in the mucosa by means of endoscopic resection, for example, the resection of polyps and/or tumors of the gastrointestinal mucosa.

Abstract: A paper-thin, one-piece, reusable gender-conscious nasal congestion to mitigate the morbidity/mortality from airborne broad-spectrum pathogens with elemental gold nanosheets. Climate warming coupled with World population's explosion with increased population intra-inter-mobility will weigh on air-born infections and transmissions by an order of magnitude. Global demand for a gender-conscious nasal broad-spectrum biocide which is reusable and affordable, is estimated at three (3) billion dollars.

Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.

Abstract: Biodegradable drug delivery systems, such as extruded implants, for the sustained delivery of a protein to an ocular region of the eye or intraarticular region in the body are described. The drug delivery systems may be used to treat a variety of ocular and medical conditions, including macular degeneration. Methods for using and making the drug delivery systems are also described. The drug delivery systems can be in the form of extruded filaments configured for placement in an ocular region such as the vitreous body or anterior chamber of the eye.

Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.

Abstract: A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional radical scavenger hydrogel formulation is generally formed from a hydrogel, a first radical scavenger and a second radical scavenger differing from the first radical scavenger with respect to at least one property. A portion of the first radical scavenger included with the formation and/or second radical scavenger included within the formulation may be dissolved, suspended and/or bonded to a polymer of the hydrogel.

Abstract: A lipid emulsion composition including soybean oil, egg lecithin, glycerol and, or osmolality and method for treating acute cannabinoid intoxication or intoxication from other substances, such as alcohol or other drugs, by orally or intravenously administering this composition according to a predetermine protocol to treat patients experiencing acute cannabinoid intoxication or intoxication from other substances. The lipid emulsion composition could be administered to the intoxicated patient orally or intravenously. In some embodiments, the lipid emulsion composition includes soybean oil, egg yolk phospholipids, and glycerin.

Abstract: The present disclosure provides a solution preparation for aerosol inhalation of carbocisteine, and a preparation method therefor. The solution preparation for aerosol inhalation of carbocisteine of the present disclosure comprises carbocisteine, a salt thereof and/or a hydrate thereof, a metal complexing agent, a pH adjusting agent, and water for injection. The solution preparation for aerosol inhalation of carbocisteine of the present disclosure has the characteristics of high efficiency, low toxicity, good stability and high safety, and particularly, greatly reduces the hepatotoxicity and the renal toxicity to patients using the drug.

Abstract: The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.

Abstract: Metastable liposomal formulations for hydrophobic drug delivery to a tissue or tissue lumen such the bladder have been developed. These are at least one micron in diameter and formed of one or more lipids having entrapped in the lipid a hydrophobic therapeutic, prophylactic or diagnostic agent. The greater stability of these liposomes, as well as the enhanced transfer of entrapped agent into the adjacent tissue, provides for better delivery, especially of hydrophobic agents such as tacrolimus which does not penetrate tissue well. The metastable liposomal formulations can be administered locally, preferably by instillation, or topically, for example, by spraying or painting, to a tissue or tissue lumen such as the bladder in need of treatment.

Abstract: A process for preparing and isolating pharmaceutical active ingredient particles having a particle size of between about 0.1 and 30 microns, wherein a slurry comprising the active ingredient and one or more pharmaceutically acceptable excipients is fed into a thin film evaporator under suitable conditions for less than 10 minutes sufficient to generate solid matrix particles comprising active ingredient and one or more excipients, wherein the particles have less than 5% residual solvent.

Abstract: A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent is a histone deactylase inhibitor.

Abstract: Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, and intracystic injection.

Abstract: The present invention relates to a targeted hydrophobic anti-tumor drug nanoformulation, which comprises a hydrophobic anti-tumor drug and a carrier with a mass ratio of 1:4-32.5, wherein the carrier is composed of 37.5-95.3 wt % albumin and 4.7-62.5 wt % hyaluronic acid-albumin conjugate, and the hyaluronic acid-albumin conjugate is prepared by albumin and hyaluronic acid with a molar ratio of 1:1-20. A preparation method of the nanoformulation comprises: preparing hyaluronic acid-albumin conjugate; formulating carrier solution; formulating drug solution; and preparing nanoformulation. The nanoformulation has even particle size distribution and good dispersibility, is stable without aggregating. The particle size of the lyophilized nanoformulation after being redissolved substantially remains unchanged, the yield of the nanoformulation is high and the efficacy is good after being filtered by a millipore filter (0.22 ?m).

Abstract: Methods and compositions are provided for lyophilization of bacteria or Listeria strains, such as Listeria monocytogenes. Provided are methods for producing a lyophilized composition comprising a bacteria or Listeria strain, formulations for lyophilization comprising a bacteria or Listeria strain, lyophilized bacteria or Listeria strains, and methods of preparing frozen bacteria or Listeria strains for lyophilization.

Abstract: The present invention is directed to oral neuro-attenuating ketamine (NAKET) tablet formulations, and methods of administration, which ensure the steady release of a therapeutically effective concentration of ketamine from an oral tablet without neurologically toxic spikes in ketamine concentration. In particular, the present invention provides single layer oral tablet formulation of NAKET. In a specific embodiment, the NAKET tablet formulation, and methods of administration provide steady administration of NAKET to a subject for 24 hours or greater, for example, up to 36 hours, after a single administration event.

Abstract: An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.

Abstract: The present disclosure provides extended release trihexyphenidyl compositions suitable for once- or twice-daily administration. The compositions comprise a core comprising organic acid that is coated with at least one drug layer comprising trihexyphenidyl hydrochloride, and a functional coat over the drug-layered core. The extended release compositions of the disclosure provide reduced Cmax, a Cmin:Cmax ratio of ?0.4, and extended release, while maintaining therapeutically effective concentration, of trihexyphenidyl for at least about 16 hours. The compositions of the disclosure improve solubility of trihexyphenidyl hydrochloride, at a pH of greater than or equal to 5, to maintain its minimum effective concentration at such pH.

Abstract: The present invention is directed to an oral pharmaceutical dosage form comprising a capsule containing at least two tablets, each tablet containing at least one different pharmaceutically active ingredient

Abstract: Disclosed are compositions comprising beta-caryophyllene (BCP) for use in the treatment of schizophrenia, methods of making such compositions and methods of treating schizophrenia using BCP. Disclosed are also compositions comprising CB2 receptor agonists for use in the treatment of schizophrenia, methods of making such compositions and methods of treating schizophrenia using CB2 receptor agonists.

Abstract: Disclosed is the use of (+)-2-borneol in the preparation of a drug for promoting the upregulation of the expression of sphingosine kinase-1 and/or BDNF (a brain-derived neurotrophic factor). Herein, (+)-2-borneol can be used to prepare a drug for promoting the upregulation of the expression of the sphingosine kinase-1 and/or the brain-derived neurotrophic factor. The drug can induce astrocyte spreading and migration, oligodendrocyte differentiation and survival, and neurite growth and nerve regeneration, and can promote the upregulation of the expression of the brain-derived neurotrophic factor, promote the survival of neurons and the growth of axons, inhibit the expansion of the infarct volume, and achieve the effect of repairing damage at the site of an immediate injury while preventing further expansion of the infarct area to completely treat brain damage, so that the long-term therapeutic effect thereof is significantly improved.

Abstract: The present invention discloses a composition for preventing and/or treating woman dysmenorrhea; the composition includes cannabidiol and/or cannabidivarol, a penetration enhancer as well as a carrier; the mass ratio of the cannabidiol and/or the cannabidivarol to the penetration enhancer is 1:(0.1-0.8). The composition provided by the present invention can effectively relieve woman dysmenorrhea, and solve the problem of lackness of a composition of cannabidiol and/or cannabidivarol which can effectively prevent and/or treat woman dysmenorrhea in the prior art. Meanwhile, the composition provided by the present invention can also be used in preparation of a feminine hygiene product for preventing and/or treating woman dysmenorrhea.

Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.

Abstract: A pharmaceutical composition in the form of an emulsion, in particular an oil-in-water emulsion, comprising certain polyunsaturated long-chain ketones and polysorbate. The composition may be used to treat or prevent certain inflammatory or proliferative conditions.

Abstract: Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided.