Abstract: The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘Composite Method’, is carried out with a body-worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. A network of body-worn sensors, typically placed on the patient's right arm and chest, connect to the body-worn monitor and measure time-dependent ECG, PPG, accelerometer, and pressure waveforms. The disposable sensors can include a cuff that features an inflatable bladder coupled to a pressure sensor, three or more electrical sensors (e.g. electrodes), three or more accelerometers, a temperature sensor, and an optical sensor (e.g., a light source and photodiode) attached to the patient's thumb.

Abstract: Disclosed is finger cuff that is connectable to a patient's finger to aid in measuring the patient's blood pressure. The finger cuff may comprise: a shell, a bladder, and a clamping mechanism. The shell may have a finger cavity. The finger cavity of the shell may be placed under a patient's finger to receive the patient's finger. Further, the finger cavity may include a light emitting diode (LED)—photodiode (PD) pair. The bladder may include a pair of openings and the bladder may be mountable within the finger cavity such that the pair of openings surround the LED-PD pair, respectively. The clamping mechanism may be used to suitably clamp the patient's finger received in the finger cavity of the shell against the bladder mounted within the finger cavity of the shell.

Abstract: A method and system for determining anaerobic threshold intensity (AnT) of a user in a freely performed physical exercise. A physiological response of a user is measured by heart rate and measured heart rate values are recorded as heart rate data. An external workload values are recorded and are each associated with one measured heart rate values to form a plurality of data points. The data points are filtered to form accepted data points, which are classified within a plurality of heart rate segments representing a heart rate within an anaerobic threshold (AnT) of the user. A data point with highest probability is stored for each segment. A first probability factor for each accepted data point is calculated. The calculated first probability factor is compared to a stored probability factor in each segment, and the higher probability factor is retained. AnT is calculated using the stored probabilities in each segment.

Abstract: Provided is a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the rotational area profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. Thereafter, an aggregated stability map is generated map based on the plurality of rotational area profile maps, wherein the aggregated stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter level of highest rotation intensity values for that location from corresponding locations of the plurality of rotational area profile maps.

Abstract: A pulse photometry probe includes a holding member that includes a contact face which is to be in contact with living tissue of a patient, an emitter that is placed in the holding member, a detector that is placed in the holding member and detects light emitted from the emitter, and, a spacer that is disposed between the contact face and the emitter and has an opening, wherein an air layer defined by the opening is disposed between an emitting face of the emitter and the contact face.

Abstract: A first data window of a pulse waveform signal comprising a first number of samples is analyzed to determine a level of confidence that a pulse sensing device is placed correctly. If an initial level of confidence is met, the user is given positive feedback, and a second data window of a pulse waveform signal comprising a second, larger number of samples is analyzed. If an increased level of confidence is met, the user is given increased positive feedback. If a level of confidence is not met, the user is given negative feedback. If a final level of confidence is met, the user is given feedback that the pulse sensing device is placed correctly.

Abstract: The invention relates to a computer-implemented medical data processing method for determining a heartbeat signal describing the heartbeat of a patient in the time domain, the method comprising executing, on a processor of a computer, steps of: a) acquiring, at the processor, acceleration measurement data describing an acceleration in the time domain of an anatomical body part measured on an external surface of the anatomical body part; b) determining, by the processor, component analysis data describing a result of an independent component analysis in the time domain of the acceleration measurement data; c) acquiring, at the processor, heartbeat template data describing template shapes of heartbeat in the time domain; d) determining, by the processor and based on the component analysis data and the heartbeat template data, recurrent shape data describing a recurrence of certain signal shapes in the component analysis data; e) determining, based on the recurrent shape data, heartbeat signal data describing a

Abstract: A system that assesses health condition by measuring pulse includes: a pulse measuring device that measures an artery of a user who receives assessment of health condition; a terminal that has a function that transmits measured-value data on pulse measured by the pulse measuring device to a health assessing administrator and receives information from the health assessing administrator; an administrative server that is administered by the health assessing administrator, analyzes the measured-value data transmitted from the terminal, and stores various data on health condition that is necessary to assess and analyze health condition. The user transmits the measured-value data on measured pulse from the terminal to the health assessing administrator, and the health assessing administrator transmits assessment information on health condition analyzed by the administrative server to the terminal.

Abstract: A vital information measurement device and a vehicle seat which improves the durability of sheet-shaped sensors configured to detect vital information of a seated passenger can stably measure the heart rate of the seated passenger. A vehicle seat includes sheet-shaped sensors attached to a seat back, and can measure the heart rate of a seated passenger based on vital signals of the seated passenger detected by the sheet-shaped sensors. At each sheet-shaped sensor, a sensor overlap reduction section is provided to reduce partial overlapping of the sheet-shaped sensor when the seated passenger leans on the seat back. Specifically, each sheet-shaped sensor includes a first cutout extending toward the center of the sheet-shaped sensor at an outer peripheral portion of the sheet-shaped sensor, and a second cutout formed continuously from the first cutout and extending opposite to the center along the outer peripheral portion of the sheet-shaped sensor.

Abstract: To provide a biomedical electrode which is capable of restraining displacement or release of the electrode even if a living body takes a hard action, and which is mountable without an occurrence of discomfort. This biomedical electrode has conductive gels 11, 11, retaining members 12, 12 to retain the conductive gels 11, 11, and an adhesive surface 31a, and comprises a sheet-shaped adhesive member 30 to adhere the conductive gels 11, 11 to a living body surface S via the retaining members 12, 12, and further, the adhesive member 30 is formed in an enough size to cover substantially all regions of the retaining members 12, 12, and is configured to have liquid through holes 30b to 30b, 30c, 30c to discharge sweat which is accumulated in internal spaces R, R formed between the living body surface S and the retaining members 12, 12.

Abstract: A method of planning a patient-specific cardiac procedure according to an embodiment of the current invention includes receiving three-dimensional imaging data of a patient's heart, simulating at least one of electrophysiological or electromechanical activity of at least a portion of the patient's heart using the three-dimensional imaging data, and planning the patient-specific cardiac procedure based on the simulating. The cardiac procedure is for providing a preselected alteration of at least one of electrophysiological or electromechanical behavior of the patient's heart.

Abstract: An ear plug for arrangement in an ear canal includes at least two electrodes for detecting an EEG signal from a skin surface when the ear plug is arranged in the ear canal. The ear plug further includes a housing having an outer wall made from a resilient material, and a signal acquisition circuit. The electrodes are provided with a skin contact part arranged on an outside surface of the housing and connected through the outer wall of the housing to a supporting member on the inner part of the housing. The skin contact part and the supporting member are arranged for clamping the outer wall.

Abstract: An electrical impedance tomography device (1) includes an electrode array, including a plurality of electrodes (33) arranged spaced apart from one another, a signal feed unit (51) and a signal acquisition unit (50). A calculation and control unit (70) is configured to determine a situation with an axial twist angle of the electrode array on a thorax (34) of a human being and to provide a control signal (79), which indicates the situation with axial twist angle of the electrode array. The calculation and control unit (70) may be configured as a central unit or an array of distributed units (cloud computing) in order to determine and to provide the axial twist angle.

Abstract: An electrical impedance tomography device (1) includes an electrode array, including a plurality of electrodes (33) arranged spaced apart from one another, a signal feed unit (51) and a signal acquisition unit (50). A calculation and control unit (70) is configured to determine a current elliptical circumferential shape (20?) of the electrode array on a thorax (34) of a human being and to provide a control signal (79), which indicates the elliptical circumferential shape (20) of the electrode array. The calculation and control unit (70) may be configured as a central unit or an array of distributed units (cloud computing) in order to determine and to provide the current elliptical circumferential shape (20?).

Abstract: An imaging system includes a magnetic resonance imaging device and a radiation generator that are mechanically linked to each other such that both surround a patient bore for receiving and positioning the examination subject. The magnetic resonance imaging device has at least one main magnet for generating a magnetic field, and the radiation generator has a radiation source for generating radiation. The imaging system is configured from a static part and a part that is rotatable through an angle of rotation such that at least one rotatable main magnet is rotatable around a static radiation generation unit or a rotatable radiation generation unit is rotatable around at least one static main magnet. The imaging system includes at least two passive shim units, of which at least one static shim unit is stationary and at least one rotatable shim unit is fixedly connected to the rotatable part.

Abstract: The present invention is related to a system and method to ensure the reproducibility of the position of the feet and lower parts of the legs during Magnetic Resonance Imaging (MRI) studies, and to obtain robust quantitative information through the time. The system includes a device that is inserted into the radiofrequency coils of any MRI equipment. The device includes a foot support section, a leg support section and a base adapted to allow that the abovementioned sections be fixed in it. With this device and method, and through external and internal markers, quantitative studies of the evolution of pathophysiological phenomena that affect the anatomy and physiology of the feet and lower parts of the legs are performed.

Abstract: An apparatus and method for determining a volume of tissue mass destroyed. The present invention includes a temperature probe and a laser probe having a temperature sensor. The laser probe and temperature probe are inserted to measure a temperature of the tissue mass and a temperature of tissue mass surrounding the tissue mass. By determining the volume of tissue mass destroyed, a graphical representation of the volume of tissue mass destroyed is provided whereby real-time visual monitoring of the destruction of the tissue mass is achieved.

Abstract: A method of obtaining information about the position and/or orientation of a magnetic component relatively to a magnetometric detector, the magnetic component and the magnetometric detector being moveable independently from each other relatively to a static secondary magnetic field, the method comprising the steps of: measuring in the presence of the combination of both the magnetic field of the magnetic component and the static secondary magnetic field essentially simultaneously the strength and/or orientation of a magnetic field at at least a first position and a second position spatially associated with the magnetometric detector, the second position being distanced from the first position; and combining the results of the measurements to computationally eliminate the effect of the secondary magnetic field and derive the information about the position and/or orientation of the magnetic component.

Abstract: Methods, systems, and devices for measuring respiratory parameters from an ECG device are described. The method may include receiving an electrocardiogram (ECG) signal associated with a patient. The method may further include detecting a change in modulation of the ECG signal between a first portion of the ECG signal and a second portion of the ECG signal. The method may further include determining a change in respiratory effort of the patient based at least in part on the change in modulation.

Abstract: A method of determining a length of an object by using an electronic device includes obtaining, by the electronic device, a length, of the electronic device, between a first point and a second point on the electronic device; obtaining, by the electronic device, a tension applied to a third point on the electronic device, the third point being located between the first point and the second point; and correcting the obtained length by using the obtained tension and prestored reference tension information, the prestored reference tension information indicating a relationship of the tension applied to the third point with respect to the length of the object, and determining the corrected length as a final length of the object.

Abstract: The ability to capture an undistorted image of the foot or foot and ankle is essential to the production of effective custom orthotics and shoes. This patent solves the problem of providing an accurate three-dimensional measurement of an undistorted foot/ankle by using a system involving the automated and controlled orbit of a point cloud capture device around the foot/ankle with the foot/ankle in a non-weight bearing position so as to capture a three-dimensional image.

Abstract: According to an embodiment, a gait analysis device includes a measuring unit configured to measure a subject's motion; a determining unit configured to determine a walking start point in time at which the subject starts walking based on the subject's motion; a feature quantity calculator configured to, when the walking start point in time is determined, calculate a feature quantity of the subject's motion measured during a predetermined time period starting from the walking start point in time as a time period in which the subject's motion is not stabilized; and an estimating unit configured to estimate a subject's walking condition based on the feature quantity.

Abstract: A medical sensor device includes a sensor assembly including an underside surface for attachment against a patient's skin, a sensor portion to detect a characteristic of the patient, and sensor assembly contacts which in operation carry signals representing the detected characteristic. The device also includes a transmitter assembly removably engageable with the sensor assembly and including circuitry to take the signals from the sensor assembly contacts and to transmit readings of the detected characteristic to external equipment. The device also includes mechanical interface components on the sensor assembly and the transmitter assembly which allow the transmitter assembly to be brought into abutment with the sensor assembly at a first angular position via relative axial movement between them, and then allow a relative rotation of the assemblies with respect to one another towards a second angular position and presents axial separation of the assemblies in the second angular position.

Abstract: Provided is a technique for calculating an oxygen extraction fraction by using MRI where the oxygen extraction fraction in a brain including brain parenchyma is calculated via a simple processing without an impact on an examinee, such as administration of caffeine. For this purpose, an MRI apparatus of the present invention measures a complex image of nuclear magnetic resonance signals, and calculates from thus measured complex image, a physical property distribution for obtaining a physical property image reflecting the oxygen extraction fraction. Then, thus calculated physical property distribution is separated into tissue-specific physical property distributions for at least two tissues (separated tissue images). After converting any of the separated tissue images into the oxygen extraction fraction, a distribution of the oxygen extraction fraction is estimated based on the condition that a value of any selected pixel is substantially equal to a mean value of pixels surrounding the selected pixel.

Abstract: A light-based method and technique for measuring the static and average plasma glucose concentration over a prolonged period of time. More specifically, the disclosure relates to a method that utilizes mathematical analysis of appendage mobile LED flash IR light transmittance, absorption and scattering by using high resolution mobile camera data to estimate the concentration of glucose and glycated hemoglobin (HbA1c) in millimoles per liter (mmol/L).

Abstract: Disclosed herein are systems and methods for providing a compressible interconnect for allowing electrical communication between an electronics unit and an analyte sensor in an on-body analyte monitoring device. In other embodiments, systems and methods are provided for reducing the Z-height of an on-body analyte monitoring device by utilizing novel interconnects.

Abstract: A multi-sensor non-invasive blood glucose monitoring instrument based on impedance spectroscopy-optical method, which belongs to a blood glucose measuring instrument for human body. The blood glucose monitoring instrument comprises a detection probe, a microprocessor, a display unit and a storage unit. The detection probe comprises a temperature and humidity sensor, an LED array, a photoelectric sensor, a pair of low-frequency electrodes, and a pair of high-frequency electrodes. The high-frequency electrode employs parallel electrodes, a matching inductor is directly soldered to the positive electrode or negative electrode of the electrode, and a shielding electrode is provided around the high-frequency electrode. The distance between the two low-frequency electrodes is 1 cm-2 m, and the low-frequency electrodes can test the low-frequency impedance of the tissue stably.

Abstract: A flexible, body-mountable analyte sensing device includes a flexible substrate configured for mounting to skin of a living body. The sensing device additionally includes a sensor probe attached to the flexible substrate and configured to penetrate the skin such that a sensor disposed on the end of the sensor probe can be exposed to an analyte in interstitial fluid. The sensor could be an electrochemical sensor that includes two or more electrodes disposed at the end of the sensor probe and configured to electrochemically detect the analyte. The sensing device is configured to display detected concentrations or other information about the analyte in the interstitial fluid. The flexible substrate of the sensing device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the living body.

Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.

Abstract: This disclosure describes methods, systems, and devices configured to determine a timing of a future bladder related event of a patient. For example, a system includes processing circuitry configured to identify a timing of a plurality of bladder related events of a patient, determine, based on the timing of the plurality of bladder related events of the patient, a probability to experience a bladder related event function for the patient, the probability to experience a bladder related event function indicating a probability that the patient will experience a bladder related event at an elapsed time after a previous bladder related event, predict, based on the probability to experience a bladder related event function, a timing of a future bladder related event, and control delivery of a therapy to the patient based on the predicted timing of the future bladder related event.

Abstract: A system for tracking a bone-altering tool in computer-assisted surgery, comprising a first trackable reference secured to a first bone, with a first frame of reference being associated with the first trackable reference. A bone-altering tool is securable to the first bone in a secured configuration. Sensors track the trackable reference for position and orientation. A position/orientation calculator is connected to the sensor device to calculate a position and orientation of the first frame of reference. An alteration parameter calculator is associated with the position/orientation calculator to determine a position and orientation of the bone-altering tool in the secured configuration as a function of the position and orientation of the first frame of reference and of the secured configuration. A method for tracking tools using the tracking of a bone is provided.

Abstract: A system and a method for detecting a muscle activity are provided. The system includes a vibration sensor. The vibration sensor detects a vibration signal at a sensing point located at an opposite side of an operating muscle system for analyzing a body movement.

Abstract: A dental instrument configured to measure a degree of tapering of a side wall of a tooth is described. The dental instrument may include a handle and a taper measuring component coupled to a distal end of the handle. The taper measuring component includes a first, second, and third elongated member. A bottom surface may be formed at a coupling point of the second and third elongated member, where the second elongated member is configured to be substantially vertical when the bottom surface is placed adjacent to a tooth, and the third elongated member projecting radially from the second elongated member at a predefined angle. The third elongated member is shaped and positioned to rest substantially flush along the at least one side wall of the tooth when a degree of tapering of the tooth is substantially similar to the angle, and may include a measuring component.

Abstract: Sensing circuitry of an implantable medical device (IMD) system may sense a cardiac signal that varies according to a cardiac cycle of a patient. Processing circuitry of the IMD system may determine a series of consecutive cardiac cycle length metric values based on the sensed cardiac signal, identify a plurality of pairs of the cardiac cycle length metrics, each of the pairs of cardiac cycle length metrics separated by an integer ‘n’ of the cardiac cycle length metrics, and construct a distribution of the pairs of cardiac cycle length metrics based on values of the cardiac cycle length metrics for each of the pairs. The processing circuitry may detect a sleep apnea episode of the patient based on one or more characteristics of the constructed distribution, and control communication circuitry of the IMD system to transmit an indication of the detected sleep apnea episode to the external computing device.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: Devices are provided to automatically inject drugs or other payloads into or beneath skin. These devices include an injector configured to drive a hollow needle into the skin and subsequently to deliver the payload through the hollow needle. Applied suction acts to draw blood from the puncture formed in the skin through the hollow needle, into the device, and to a sensor, blood storage element, or other payload. In some examples, the blood is drawn through the hollow needle when the hollow needle is penetrating the skin. In some examples, these devices are additionally configured to retract the hollow needle from the skin and/or to perform some other functions. These devices can be wearable and configured to automatically access blood or deliver a payload into skin, for example, to operate at one or more points in time while a wearer of a device is sleeping.

Abstract: A method, display apparatus, and display system for displaying an image of an abdominal cross-section includes storing plural abdominal CT sample images that have at least either of different visceral fat areas or different subcutaneous fat areas, estimating at least one of a visceral fat area and a subcutaneous fat area of an abdominal cross-section, and displaying an abdominal CT sample image corresponding to the estimated at least one of the visceral fat area and the subcutaneous fat area from among the plural abdominal CT sample images.

Abstract: A headgear for placing sensors on a subject's head includes a centerpiece; a plurality of arms attached to and radiating outward and generally downward from the centerpiece; and sensor tips attached to the dorsal ends of at least some of the arms. At least one of the plurality of arms is a lower arm that is elastic and/or spring-like. When the headgear is placed on a subject's head, the at least one lower arm is so disposed in relation to the maximum circumference of the subject's head that the at least one lower arm must be bent outward for placement of the headgear on the subject's head and thereby provide a reactive force toward the head that causes the at least one lower arm to grasp at least a portion of the head that is at and/or below the maximum circumference of the head.

Abstract: A sensor garment for monitoring an individual engaged in an athletic activity includes a garment formed of textile material, and a sensor module inseparably coupled to the textile material of the garment. The sensor module includes a single-purpose sensor configured to sense a single characteristic, and a radio antenna configured to transmit data generated by the single-purpose sensor. The sensor module includes no external port.

Abstract: A smart bracelet (100) is provided. The smart bracelet (100) has a length direction, and includes: a first pulse detector (12) and a blood flow sensor (11) sequentially arranged along the length direction, wherein, the blood flow sensor (11) is configured for identifying a blood flow direction and sending a blood flow direction signal; the first pulse detector (12) is configured for detecting a pulse signal. The smart bracelet (100) can intelligently detect whether it is worn on a left hand or a right hand and avoid manually input.

Abstract: An appliance includes a belt that is worn by being wound around a wrist. The appliance includes: at least a first display region that is positioned in an area of the belt that corresponds to a volar-side surface or a radius-side surface of the wrist; and a second display region that is positioned in an area of the belt that corresponds to a back-side surface of the wrist. During a blood pressure measurement period, first control for displaying ongoing blood pressure measurement information only on the first display region is performed, and during a period other than the blood pressure measurement period, second control for displaying information that needs to be displayed on the first or second display region is performed.

Abstract: Modular physiological sensors that are physically and/or electrically configured to share a measurement site for the comfort of the patient and/or to ensure proper operation of the sensors without interference from the other sensors. The modular aspect is realized by providing outer housing shapes that generally conform to other physiological sensors; mounting areas for attachment of one sensor to another sensor; providing release liners on the overlapping sensor attachment areas; and/or providing notches, tabs or other mechanical features that provide for the proper placement and interaction of the sensors.

Abstract: Exemplary implementations may provide objective, continuous, and clinically useful assessment of asthma control in subjects including young children using a device that is compact, non-intrusive, and simple. The device may include a water-resistant, flexible patch that can be comfortably worn for two weeks or more. In some implementations, the patch may resemble a Band-Aid® that is placed on the supra-sternal notch. The device may record respiratory sounds that can be analyzed to identify coughing and wheezing episodes. The device may operate in different modes including ones for assessment of nocturnal symptoms, exercise-induced asthma, and overall asthma control. The device may be useful for objectively assessing asthma control to aid clinical therapy, and for an improved way to diagnose exercise-induced asthma.

Abstract: A simple, disposable sensing device for sensing an analyte is housed in a single case. The sensing device can transmit sensor data to monitoring device(s). The sensing device includes: a case having a lower major wall adapted to be mounted against a patient's skin, and an upper opposing major wall; a sensor extending from the case and having a distal end sensitive to the analyte to produce an electrical signal, and a proximal end within the case having electrical contacts; a printed circuit board assembly within the case supported by one of the major walls to receive the electrical signal via the electrical contacts; and an elastomeric pad disposed in the case and biased by the other major wall to urge the proximal end of the sensor into contact with the printed circuit board assembly and maintain an electrical connection between the electrical contacts and the printed circuit board assembly.

Abstract: Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

Abstract: A three-dimensional (3D) electrical mapping system and method may be used to generate a 3D image of the epicardial surface of a heart by integrating one or more epicardial images with a 3D image of the cardiac structure that may be generated by real-time 3D location and mapping system for cardiac mapping and ablation. The visual textural representation of the epicardial surface of the heart may be reconstructed using, for example, an image sensor or camera-based catheter to collect images of the epicardial surface. For each image that is captured, the system and method may store the image data along with the corresponding catheter location, orientation and/or distance information relative to the cardiac structure. The location, orientation, and/or distance information may be used to reconstruct a 3D textural model of the epicardial surface of the cardiac structure.

Abstract: Various embodiments of a sealed package and a method of forming such package are disclosed. The package can include a non-conductive substrate that includes a cavity disposed in a first major surface. A cover layer can be disposed over the cavity and attached to the first major surface of the non-conductive substrate to form a sealed enclosure. The sealed package can also include a feedthrough that includes a via between a recessed surface of the cavity and a second major surface of the substrate, and a conductive material disposed in the via. An external contact can be disposed over the via on the second major surface of the non-conductive substrate, where the external contact is electrically connected to the conductive material disposed in the via. The sealed package can also include an electronic device disposed within the sealed enclosure that is electrically connected to the external contact.

Abstract: An analyte monitoring system may include an analyte sensor and a transmitter. The analyte sensor may include an indicator element that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator element. The analyte sensor may be configured to generate one or more raw signals indicative of one or more analyte amounts or concentrations. The transmitter may be configured to receive from the analyte sensor one or more raw signals indicative of analyte concentration. The transmitter may be configured to denoise the raw signal using a real-time filtering technique with one or more time-varying parameters. The transmitter may be configured to predict ahead of time an analyte concentration based on one or more of the received one or more raw signals using one or more prediction models.

Abstract: A client device includes a display and a processor configured to obtain a data stream from a remote sensor via a communication protocol. The remote sensor is a physiological sensor monitoring a subject and/or an environmental sensor monitoring an environment in a vicinity of the subject, and the data stream includes a sensor metric, a metric identifier, and dynamically updated integrity information about the sensor metric. The processor is also configured to identify a statistical distribution function associated with the remote sensor via a function selector associated with the communication protocol, and display, via the display, the sensor metric with statistical information about the sensor metric using the identified statistical distribution function.

Abstract: Systems and methods are provided for operating a physiological monitoring system for determining a physiological parameter of a subject. The physiological system may comprise a pulse oximetry sensor for generating a photoplethysmography (PPG) signal and a gain controller for setting a light detection level. The system may also comprise a filter for filtering the PPG signal. The filter may comprise at least one of filter history and filter coefficients. The system may comprise a processor for determining the power level of light sources of the pulse oximetry sensor and the light detection gain level, and calculating a scaling factor based on the determined power level and the light detection gain level. The processor may also be used for scaling one or more of the filter history and filter coefficients based on the scaling factor, and determining at least one physiological parameter based on the filtered PPG signal.