Abstract: A device for synthesizing a radiotracer includes a microfluidic chip having a concentration module configured to concentrate and capture a radioactive reagent from a radioactive regent mixture, a reaction chamber in fluidic communication with the concentration module and configured to synthesize a radiotracer by reaction of the concentrated radioactive reagent and a radiotracer precursor therein, and a purification module in fluidic communication with the reactor chamber and configured to purify the synthesized radiotracer. The device also includes a heating means positioned in relation to the microfluidic chip for heating the microfluidic chip during evaporation and reaction; and a first valve fluidically coupled with the concentration module and the reaction chamber and a second valve fluidically coupled with the reaction chamber and the purification module for operably controlling transit of various substances or mixtures among the concentration module, the reaction chamber and the purification module.

Abstract: The present disclosure provides immunes cells comprising a radiolabeled tracer useful in imaging tests such as positron emission topography (PET)/computed tomography (CT) scans. The present disclosure further includes engineered cells comprising a chimeric antigen receptor (CAR) further comprising a nucleic acid molecule comprising a ligand binding domain capable of binding to radiolabeled tracer. This disclosure also includes methods for assessing the efficacy or toxicity of an adoptive cell therapy in a subject, methods for detecting the quantity of engineered T cells in a subject, methods for monitoring an immunotherapy treatment in a subject and methods of imaging engineered T cells in a subject. In some embodiments, the radiolabeled tracer is [18F]fluoropropyl-trimethoprim ([18F]FPTMP).

Abstract: The present invention relates to radiolabeled compounds of formula I wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.

Abstract: Targeted pharmaceuticals, particularly targeted radiopharmaceuticals, are provided which possess extended tumor retention time.

Abstract: An apparatus for decontaminating and storing lab instruments such as pipettes. A carousel feature of the apparatus provides convenient access and allows multiple items to be decontaminated at the same time. The ultraviolet lamp directs UV radiation to surface contaminations of the instruments and effectively eliminates various microorganisms.

Abstract: A powder sterilization method for sterilizing powder, in particular an active pharmaceutical ingredient in powder form or food in powder form, using fluid vapor, in particular steam. According to the invention, the fluid vapor is applied to the powder in an evacuated treatment chamber (3), in particular it is applied to the powder during its free fall along a drop section (7), in particular in countercurrent.

Abstract: Described herein are packages for orienting and cooling polyesters during a sterilization process, and containers for storing, transporting, and cooling the package. Also described herein are methods of sterilizing polyesters.

Abstract: Described herein is a sanitization assembly including: a sanitization device, such as for example a photocatalytic device or ionizer or the like; and a containment element. The sanitization device is received in the containment element, and the containment element includes a box-shaped, box-like containment body. The box-like containment body includes side containment body surfaces and has dimensions in the width and thickness thereof that are substantially the same as those of a panel or rack or shelf of a furnishing element that includes side shelf surfaces. The box-like containment body can be assembled on the panel or rack or shelf, thus being continuous with the panel or rack or shelf. The side shelf surfaces substantially continue in the side containment body surfaces.

Abstract: The present invention relates to mobile devices for disinfecting an object. The mobile device includes: one or more light sources for generating a disinfection light; a display; one or more processors coupled to the one or more light sources and display; and a non-transitory computer-readable medium comprising one or more sequences of instructions which, when executed by the one or more processors, causes steps to be performed including: determining a required dosage of the disinfection light; determining an exposure time of the disinfection light that corresponds to the required dosage of the disinfection light; illuminating the disinfection light on the surface; and displaying a disinfection map on the display to report a result of a disinfection process performed by the illumination of the disinfection light.

Abstract: A system and methods for sterilizing and drying contaminated articles, particularly medical articles, and more particularly the hollow internal areas of medical instruments or lumens of medical endoscopes. The system includes a plasma generator having an electrode, a shield, and a dielectric gap between the electrode and the shield. A source of electrical power connected to the plasma generator applies an electrode energy density between the electrode and the shield. A source of a sterilizing gas precursor provides a flow of the sterilizing gas precursor through the plasma generator to generate a plasma, thereby forming a sterilizing gas including acidic and/or oxidizing species. The contaminated article is exposed to the sterilizing gas for a time sufficient to achieve a desired degree of sterilization. A turbulent flow of a drying gas is used to dry the contaminated article alternately with the exposure of the contaminated article to the sterilizing gas.

Abstract: Disclosed is a process for treating at least one hollow body made of thermoplastic material, such as a preform or a cap, the treatment process successively including at least the following steps: a first step, consisting in treating at least the inside of the hollow body using hydrogen peroxide; a second step, consisting in heating the hollow body; a third step, consisting in treating the hollow body with plasma in order to reduce the concentration of hydrogen peroxide residues. Also disclosed is a plant for manufacturing containers in which the process is carried out in particular by way of a unit for the plasma treatment of the preforms.

Abstract: The deodorant dispersion of the present invention includes (A) two or more powdery inorganic chemical adsorbents, (B) a dispersing agent, and (C) a dispersion medium, a content proportion of the component (A) is in a range from 10% to 30% by mass based on a total of the deodorant dispersion, a content proportion of the component (B) is in a range from 1% to 10% by mass based on a total of the deodorant dispersion, and a median particle diameter of a dispersoid is in a range from 0.1 ?m to 0.4 ?m. A gas adsorption capacity of the component (A) is preferably 25 mL/g or more.

Abstract: A device for evaporating volatile substances including a solid body impregnated with volatile substances and a support for the solid body. The solid body includes a protrusion defining on the inside thereof a housing and the solid body includes a hole, inside of which the protrusion is placed, such that the device further includes a container to house a liquid which impregnates the solid body with volatile substances. The device allows the solid body to be correctly held in the support during the entire useful life thereof. Furthermore, due to the presence of the container with liquid, the user may know if the device is still evaporating the volatile substances correctly or if it must be replaced.

Abstract: A scented plug-in night light provides a pedestal for variable, interchangeable thematic character statuettes, which are illuminated by the scented plug-in night light. The scented plug-in night light is optionally provided with a digital clock incorporated into the housing for the scented night light to turn on the night at specified times to illuminate a child's favorite thematic character, which can serve as an inducement for a child who is reluctant to observe bedtime. Thereafter the illuminated thematic character of the night light stays on to act as a safety night light during the selected duration of time, and an alarm for waking the child.

Abstract: A fluid disinfecting system includes a straight fluid directing conduit and a light source disposed on a side of the fluid directing conduit. The light source is operative to emit ultraviolet light into the fluid directing conduit, such that one or more cross sections of said fluid directing conduit are saturated with ultraviolet light. Any fluid passing through the fluid directing conduit is necessarily exposed to the ultraviolet light.

Abstract: A biodegradable, disposable absorbent article, such as a diaper, having a non-woven inner layer of natural fibers and a non-woven outer layer of natural fibers and a treatment applied to at least one surface thereof. The treatment includes at least one compound selected from the group consisting of waxes, urethanes, silicones, fluorocarbons, and non-fluorochemical repellants. The absorbent article has a core of natural fibers or fibrous material, and optionally polyacrylate superabsorbent particles, positioned between the inner layer and the outer layer. The article may contain polylactic acid films between the layers.

Abstract: Disposable absorbent articles assembled from a collection of components using an adhesive having an amorphous polyolefin composition with a random butane-?-olefin copolymer and a heterophase polyolefin copolymer composition with a first set of comonomer units and a second set of comonomer units, wherein the first set of comonomer units are propene.

Abstract: Disclosed is a medical material manufactured using collagen and a method of manufacturing the same. The method includes (1) preparing collagen using distilled water as a solvent, (2) filling a syringe with the prepared collagen and then spinning the collagen through a syringe needle, (3) immediately immersing the spun collagen in a cross-linking solution, which is a mixture including therein a hyperosmotic agent and a cross-linking agent mixed with each other, (4) removing and then washing the collagen after cross-linking is completed, and (5) removing and then drying the collagen after the washing is completed. When the collagen is spun and processed into the form of a thread and the spun thread is then cross-linked, the cross-linked collagen thread has increased strength compared to before cross-linking, and the shape thereof is retained in an aqueous solution.

Abstract: The present invention relates to an alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof. The alkyl chitosan-graphene oxide composite sponge provided by the present invention includes alkyl chitosan and graphene oxide absorbed on the alkyl chitosan, and the adsorbing capacity of the graphene oxide is 3-28 wt. %. In the present invention, alkyl chitosan is used as a matrix to combine graphene oxide and alkyl chitosan; the obtained composite sponge has excellent hemostatic performance and blood absorption capacity. Results of embodiments indicate that the in-vitro whole blood coagulation time is less than 58 s, the hemostasis time of a rabbit femoral artery hemorrhage model is less than 155 s, the hemorrhage mass is less than 5.4 g, and the hemostatic effect is superior to a pure alkyl chitosan sponge or graphene oxide powder when the composite sponge provided by the present invention is used for hemostasis.

Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

Abstract: The invention relates to the field of medicine and medical technology, namely to bone implants, and can be used in surgery, orthopedics, dentistry. Bone implants made of dense tough fibrous or fine-crystal silicate mineral aggregate or rock, jade, have high strength, resistance to crack formation, biological compatibility and the ability to integrate into bone tissue. The technical result—expanding the field of medical devices for implantation into bone tissue.

Abstract: Soft hydrophobic acrylic materials with improved resistance to fluid diffusion and suitable mechanical properties that allow deformation upon application of force are disclosed. The acrylic materials are particularly suitable for use in fluid-based accommodating intraocular lenses and comprises combination of a perfluoro-substituted alkyl (meth)acrylate and an alkyl (meth)acrylate, and a cross-linking agent.

Abstract: Collagen compositions, methods for preparing those collagen compositions, and 3D constructs formed from those collagen compositions are provided. In particular, methods of isolating collagen that exhibits an enhanced rate of gelling, such collagen compositions, and 3D constructs formed from such collagen compositions are provided.

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.

Abstract: A cardiac patch for treatment of a mammalian heart including perfusable vessels embedded integratedly between two layers of anisotropically oriented myocardial fibers. The cardiac patch is made using a dual 3D bioprinting technique using stereolithography to form an anisotropic construct and extrusion printing to form perfusion vessels. A nutrient and oxygen containing media can be provided within the perfusion vessels for growth of cells in the cardiac patch. The technique permits larger patches to be made for the treatment of cardiac damage in both small and large mammalian hearts.

Abstract: A process of forming a coated textile includes culturing human cells on a fiber of a textile such that the human cells produce and deposit human extracellular matrix (hECM) on the textile. The process also includes removing the human cells from the hECM to provide the coated textile of the textile and a coating comprising a residual of the hECM produced and deposited by the human cells on the textile during the culturing. A coated textile includes a textile and a coating on the textile. The coating includes hECM in a cell-deposited state in the coating. A solid-state bioreactor composition includes a poly(glycerol sebacate) (PGS) adduct. The PGS adduct includes PGS and a promoting factor or a promoting factor precursor. Another method includes implanting a coated textile in a human. The coated textile is an autograft. The coating includes hECM deposited by human cells from the human.

Abstract: One aspect of the present disclosure can include a biocompatible tissue graft. The graft can include an extracellular matrix (ECM) patch or strip and at least one fiber stitched into the ECM patch or strip in a peripheral reinforcement pattern. The at least one fiber can have opposing terminal ends. The at least one fiber can mitigate tearing and/or improve fixation retention of the ECM patch or strip. The at least one fiber can comprise a plurality of interconnected stitches. The opposing terminal ends of the at least one fiber can be stitched together to form a continuous stitching construction.

Abstract: Described are embodiments of a multilaminate or multiple layer implantable surgical graft comprising remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

Abstract: Disclosed herein are methods of regional gene-therapy with growth-factor transduced cells, in bone graft scenarios. In embodiments, the methods comprise use of 3D printed scaffolds.

Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 ?m; providing a dispersion of bioactive ceramic particles of particle size at most 10 ?m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent. Further disclosed is an osteoconductive polymer article for use as an orthopedic implant, which article is made from a biocompatible, non-biodegradable polymer and comprises a non-flat surface with roughness Ra of at least 5 ?m, wherein bioactive ceramic particles of particle size at most 10 ?m are partly embedded in the polymer at the surface of the article.

Abstract: A method of producing an injectable gel product is provided, comprising (a) cross-linking a first glycosaminoglycan (GAG) with a first crosslinking agent to produce a gel, wherein the charging ratio of crosslinking agent to disaccharide unit is below 0.15; (b) preparing particles of the gel; (c) mixing the glycosaminoglycan (GAG) gel particles with a second GAG to provide a mixture; (d) cross-linking the mixture with a second crosslinking agent to obtain cross-linking between the GAGs of the second, outer phase, thereby providing a gel having a first, inner phase of the cross-linked GAG gel particles, embedded in a gel of the second GAG outer phase; and (e) preparing injectable particles, each such particle containing a plurality of the cross-linked GAG gel particles of the first, inner phase. An injectable gel product, an aqueous composition, and a pre-filled syringe as also provided.

Abstract: The present disclosure relates to bioactive hydrogels derived from human blood plasma. More particularly, the disclosure relates to multifunctional materials for cell encapsulation, cell culture platforms, medical treatment apparatus and methods, more particularly, hydrogels derived from human blood components and technologies for use of such materials in research, biomedical treatment, biotech and pharmaceutical industry. The disclosure further relates to 3D printable scaffolds, sponges, foams, fibers, particles, capsules, membranes and injectable systems comprising said hydrogel. Additionally, this disclosure allows for the controlled placement of biologically active components that may be delivered by the hydrogel compositions.

Abstract: An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including at least one growth factor, a first layer including at least one of one or more interleukins and capsaicin, and a second layer including an antigen operatively arranged to activate an innate immune system.

Abstract: A composite dura substitute implant for implantation at a dura defect site having a porous layer that provides an osteoconductive scaffold for bony ingrowth, a porous layer that provides a scaffold for regeneration of collagen at a dura surface, and an intervening layer for preventing cerebrospinal leakage is disclosed. The composite dura substitute implant facilitates regeneration of dura mater and promotes osteointegration with bony tissue. Methods of manufacturing such an implant and methods of treatment using such composite dura substitute implants are further disclosed.

Abstract: A radiopaque filler material contains a mixture of a first radiopaque material and a second radiopaque material different from the first radiopaque material. The radiopaque filler material may be dispersed in a polymeric material. The polymeric material may be used to prepare a medical device or a part thereof. The polymeric material containing the radiopaque filler material exhibits a level of radiopacity that is substantially even across varying imaging energy levels.

Abstract: Disclosed are hydrogels polymerized with or around a solid biofunctional moiety, biodegradable or permanent, designed to be implantable in a mammalian body, intended to block or mitigate the formation of tissue adhesions, and intended to aid in functional healing. The hydrogels of the present invention are characterized by comprising multiphasic structural elements: a) at least one gel phase, b) at least one solid phase, c) optional polymeric chains connecting gel and solid phases, d) optional shape designs that provide for an interpenetrating geometry between gels and solids, e) optional shape designs that enhance a tissue-hydrogel interface, and f) optional shape designs that provide a biofunctional aspect. The hydrophobicity of the various phases is chosen to reduce tissue adhesion and enhance tissue healing. The morphology of the polymers comprising the gel phase is typically of high molecular weight and has morphology that encourages entanglement.

Abstract: The silicon-reinforced stent is a specially designed stent structured and arranged with a silicon coating over the metal stent structure to maintain a firmer and longer lasting stent. The silicon may be similar to Vaseline and may also prevent plaque from further accumulating in the vein. Additionally, the silicon coating will help prevent the edges of the metal structure from collapsing, thereby ensuring that if the stent moves or comes out, the movement will cause less damage.

Abstract: A bioresorbable haemostatic foam sponge for adhering to a wound. The sponge has a tissue-contacting surface divided into a plurality of closely-spaced tissue contacting elements. Also disclosed are methods for forming the haemostatic sponge and methods of using the sponge.

Abstract: There is provided inter alia a solid object having a surface comprising a layered coating of cationic and anionic polymer, wherein the outer coating layer is a layer comprising cationic polymer to which is covalently bound an anticoagulant entity; and wherein the anionic polymer is characterized by having (a) a total molecular weight of 20 kDa-650 kDa; and (b) a solution charge density of ?4 ?eq/g.

Abstract: System and methods for stimulating cartilage formation at a first tissue site through a second tissue site is presented. The system includes a fluid source for supplying a therapeutic solution, a reduced pressure source for supplying reduced pressure, a fluid delivery manifold for deploying adjacent the first tissue site, and a vacuum manifold for deploying within the second tissue site. The fluid delivery manifold extends between a proximal end fluidly coupled to the fluid supply and a distal end having at least one aperture for delivering the therapeutic solution to the defect adjacent the articulating surface of the first tissue site. The vacuum manifold extends between a proximal end fluidly coupled to the reduced pressure source and a distal end having at least one aperture for delivering the reduced pressure to the first tissue site adjacent the opposing surface of the first tissue site.

Abstract: Various aspects of a skin treatment device and a method to cleanse and balance pH value of skin are disclosed herein. In accordance with an embodiment, the skin treatment device includes a nozzle to be directed into contact with the skin of a subject. A vacuum pump may be operably coupled to the nozzle for generating a suction force of the nozzle to evacuate impurities from the skin. A liquid replenishing assembly may be operably coupled to the nozzle for atomizing liquid at a pre-defined pH value. The liquid from the liquid replenishing assembly may pass into the nozzle based on the pre-defined pH value. The first control valve may be connected to an outlet of the vacuum pump and an outlet of the liquid replenishing assembly for communication with the nozzle.

Abstract: A wound therapy apparatus is disclosed that includes a wound interface securable to a skin surface around a wound bed to form an enclosed space over the wound bed that is fluid-tight. The wound therapy apparatus-may include a dressing engaged with the wound interface to contact the wound bed. A spacer may be disposed within the enclosed space proximal of the dressing to define a plenum between portions of the wound interface and a proximal side of the dressing. Gas within the enclosed space may have an O2 concentration greater than the O2 concentration in atmospheric air. The dressing may include a hydrophobic material, hydrophobic material, or a distal layer comprised of silicone having fenestrations therein, in various aspects. The pressure p0 within the enclosed space may vary over a pressure range pmin?p0?pmax. Related methods of use are also disclosed.

Abstract: A suction-based medical dressing assembly and method of dermal irrigation provides a flexible tube that is fluidly coupled to at least two bifurcated tube portions defined by a plurality of apertures. The tube has a proximal end opening for discharging ambient fluid. The length of the bifurcated tube portions is surrounded by an absorbent gauze material covered substantially with an occlusive sheet material, and having an adhesive strip thereon. A vacuum assembly creates a negative pressure in the tubes. The ambient fluid is absorbed by the absorbent material, and the negative pressure sucks the fluid through the apertures in the bifurcated tube portions for discharge through the opening in the tube. In operation, a patient applies the adhesive side of the occlusive device to the skin where liquid removal is desired and activates the vacuum-inducing source, thereby causing fluid runoff from the patient to be effectively removed for disposal.

Abstract: A medical gauze and gas flow assembly and method of applying a medical gauze with gas flow over a wound, provides a medical dressing cover that couples to a gas flow framing structure. The gas flow framing structure provides a flow of gas over a wound. A medical grade gauze material adheres to the lower surface of the medical dressing cover, so as to create spacing between the medical grade gauze material and the wound treatment area. The gas flow is directed between the medical grade gauze material and the wound treatment area. The gas flow vents to ambient though the gas permeable medical dressing cover. When degraded, the assembly is replaced or only the medical dressing cover and medical grade gauze material is replaced. The synergistic combination of a medical grade gauze material that is a gas permeable, with a gas flow structure that discharges gas over the wound enhances healing the wound.

Abstract: Disclosed herein are improved devices, systems, and methods for the expression and collection of breast milk, such as human breast milk. A breast shield assembly for expression of breast milk may comprise a breast interface and an actuatable assembly interface fluidly coupled with a tube, wherein the breast interface is configured to engage the breast and the actuatable assembly interface is configured to removably couple to an actuatable assembly. The breast shield assembly may comprise an enclosed fluid reservoir extending between the breast interface and the actuatable assembly interface, the fluid reservoir physically separated from the expressed breast milk and filled with a driving fluid comprising a liquid. The breast shield assembly may further comprise a fill port configured to allow addition or removal of the driving fluid to or from the fluid reservoir.

Abstract: A medical fixation device which may include an elongate body with a proximal portion, a distal portion, and define a longitudinal axis extending therethrough. A first fixation member on the proximal portion of the elongate body and a second fixation member on the distal portion of the elongate body may also be included with the medical fixation device. The first fixation member and the second fixation member may each have a delivery configuration in which the first fixation member and the second fixation member are collapsed along the longitudinal axis, and an anchoring configuration in which the first fixation member and the second fixation member each extend radially outward from the elongate body, define a septal aperture therebetween, and each have a tip facing away from each other.

Abstract: A sheath device for inserting a catheter into a patient's body is described. The device has a first sheath with a proximal end and a distal end. When the device is used as intended, the distal end of the first sheath is provided for arrangement in the patient's body and the proximal end of the first sheath is provided for arrangement outside the patient's body. The first sheath comprises a tubular section and a sheath housing, which is disposed at the proximal end of the section and has a receiving channel for a strand-shaped body. The device solves the problem of reliably fixing a second sheath or a catheter with respect to the first sheath by providing a clamping element on the receiving channel for fixing a strand-shaped body in the receiving channel by way of clamping.

Abstract: A method and apparatus for long-term assisting the left ventricle of a heart to pump blood is disclosed which includes at least one transluminally deliverable pump and a transluminally deliverable support structure which secures the at least one pump within the aorta for long-term use.

Abstract: A method and apparatus for long-term assisting the left ventricle of a heart to pump blood is disclosed which includes at least one transluminally deliverable pump and a transluminally deliverable support structure which secures the at least one pump within the aorta for long-term use.

Abstract: A dialysis system may include a dialysis machine (e.g., a peritoneal dialysis machine or a hemodialysis machine) for transferring a liquid to a patient via tubing. The dialysis system may include an air management device for filtering out air content from the liquid prior to transferring to the patient. The air management device may be a connector cap for use in a peritoneal dialysis system during a priming process. Alternatively, the air management device may be a drip chamber for use in a hemodialysis system. The air management device may include a vent. In addition, the air management device may include a movable element for sealing the vent. In addition, and/or alternatively, the air management device may include a reservoir for receiving an overflow of liquid.