Abstract: The invention relates to processes for making pharmaceutical aqueous therapeutic particles (AQTP) having stable exterior water clustering with nanosized thickness less than 300 nanometers, wherein the AQTP has an improved bioavailability when administered to a mammal compared to conventional pharmaceutical drug particles administered to the mammal. The invention relates to an improved process apparatus which is computer controlled, capable of continuous operation with high efficiency so as to make a more consistently acceptable AQTP compared to an previous prototype process apparatus of the Inventors.

Abstract: A hydration system for use at night a providing hydration to a mouth of a person. The person may wish to be hydrated after a night of drinking to help hydrate and reduce hangovers, athletes to be hydrated prior to early morning competitions, fitness enthusiasts being hydrated prior to early morning workouts, patients being medicated, etc. The hydration system has a container that has a basin for containing a liquid. The container has a control board coupled to the container to control an outputting of the liquid from the container. The container further has a power source for providing electrical current to the control board. The hydration system has a connecting tube a conduit for the liquid. The hydration system has a mouthguard that has a receiving port, a first opening and a second opening. The mouthguard receives the liquid from the connecting tube at the receiving port and releases the liquid through the first opening and second opening to the mouth of the person.

Abstract: Apparatus and associated methods relate to a connected pill dispenser configured to treat a patient's illness with a robotic arm adapted to deliver a prescribed medication dose to a patient in their home, analyze the patient's response to the dose based on various sensor inputs, automatically determine whether the patient took the medicine and send the provider the result of providing the medication dose to the patient. In an illustrative example, the patient may be a chronic, acute, or terminal illness patient. The medication dose may be, for example, a medication prescribed by a doctor to be taken in a specific amount at specific times. In some embodiments, the connected pill dispenser may automatically notify the patient when a medication dose is due.

Abstract: A self-administered medicament delivery device system that desirably alert a clinician to improper and/or suboptimal patient use or compliance, and instructs and affirms the user on proper use in realtime. The invention improves the state of the art by proactively teaching and aiding users on proper techniques so the user obtains the most benefit from their device. By providing training, feedback, and reporting to both the user and the clinician, the invention allows users to make corrections immediately and allows clinicians to more accurately assess if medicine or technique is the problem in a patient whose condition is not remediated by a treatment regimen.

Abstract: The present invention relates to a glass ceramic for veneering a dental frame structure, wherein said glass ceramic is characterized by a high content of B2O3, to a process for the preparation thereof, and to the use thereof in the production of dental restorations.

Abstract: Cleansing and conditioning tablets and compositions are provided. The tablets are solid at room temperature and dissolve in water in one use (under about 15 seconds) to provide cleanser (e.g., shampoo or body wash) and conditioner for the hair and body. The tablet compositions are generally formed of between about 15 percent by weight to about 35 percent by weight of liquid components (i.e., in liquid state at room temperature) to allow the ingredients to be easily mixed together and allowed to set to form solid tablets without requiring compression to compact the solid ingredients together.

Abstract: The present disclosure concerns a cosmetic product for modifying the natural color of keratinous fibers, in particular human hair, comprising at least one packaging (VP) and a cosmetic composition (KM) contained in this packaging (VP). The packaging is made of a multi-layer film (F) comprising at least two polymer layers (P1) and (P2) and at least one barrier layer (BS). The cosmetic composition comprises at least one oxidizing agent and at least one thickening agent from the xanthane group. The use of the packaging (VP) in combination with the cosmetic composition (KM) does surprisingly not lead to an inflation of the packaging or an excessive water loss of the agent (KM) during storage.

Abstract: The present invention provides a multilayer type powder-containing cosmetic preparation which can be variously formulated and in which the powder ingredient has excellent re-dispersibility without being required to have undergone a surface treatment. The a multilayer powder-containing cosmetic preparation includes (a) to (c) components: (a) a 60-95% by mass lower alcohol; (b) a powder ingredient (excluding a (c) component); and (c) a finely particulate powder which has an average primary-particle diameter of 10-550 nm and includes silica or titanium dioxide as a core.

Abstract: The invention relates to a composition comprising an aqueous phase and an oily phase which are visually separate and superimposed, 1,3-propanediol and a ketone compound of formula (I): wherein R1 is a C2-C4 alkyl radical; R2 is H or a C1-C4 hydrocarbon-based radical; R3 is a C1-C4 hydrocarbon-based radical; and C—X is C?O. The invention can be used for the cosmetic treatment of keratin materials.

Abstract: A gelatinous composition may include a biosurfactant, water and/or a polyvalent alcohol, an oleaginous component, and an alkaline substance. The alkaline substance may be one or more selected from the group consisting of a hydroxy group-containing amine compound, an alkali metal hydroxide, and a basic amino acid. A concentration of the oleaginous component may be 50 to 99 mass %.

Abstract: Skin-tightening compositions for providing a physical tightening effect to the skin and methods for using the same. The compositions may be in the form of an oil-in-water emulsion and include about 0.1 wt. % to about 6 wt. % of sodium silicate; at least 3 wt. % to about 11.5 wt. % of magnesium aluminum silicate; about 1 wt. % to about 15 wt. % of one or more fatty compounds; about 0.1 to about 20 wt. % of one or more nonionic emulsifiers; about 1 to about 25 wt. % of one or more polyols; and about 50 to about 90 wt. % of water, wherein the weight percentages are based on the total weight of the composition. The weight ratio of the sodium silicate to magnesium aluminum silicate is from 0.08 to 1.0 and a total amount of sodium silicate and magnesium aluminum silicate is 3 wt. % to 13 wt. %.

Abstract: Skin-tightening compositions and methods for using the same, which provide a long-lasting skin-tightening effect and a mattifying finishing effect are described. The skin-tightening composition may be in the form of an oil-in-water emulsion and comprise one or more polyvalent silicates; one or more cellulose thickeners; one or more clays selected from hectorite and organically modified hectorites; one or more polysaccharide film forming agents; one or more polyols; one or more acrylate polymers; and water. The skin-tightening compositions are useful for improving the appearance of skin, especially skin of the neck and face.

Abstract: A system for delivering an active agent comprising an oral care composition, a delivery carrier, and optionally a device capable of producing electromagnetic radiation. The oral care composition can include a high internal phase oil-in-water emulsion and/or jammed oil-in-water emulsion. A method for delivering an active agent to an oral cavity including providing an oral care composition, contacting the oral care composition with at least one tooth, and optionally applying electromagnetic radiation to at least one tooth.

Abstract: The invention relates to oil-in-water emulsion in which specific oils (e.g., lauric oils) are used in the oil phase while surprisingly maintaining excellent transparency. In one aspect, said emulsions comprise fatty acid in oil phase. The invention comprises an energy efficient process for making said fatty acid containing transparent nanoemulsions.

Abstract: The present invention relates to a composition for surface modification. The composition for surface modification according to the present invention contains a particular carbodiimide-based compound, thus forms a covalent bond without damaging skin, hair, or fabric, and semipermanently provides desired skin or hair surface modification effects or fabric care effects.

Abstract: The color composition formula and method of the present invention uses a color composition to create colorful environments of single or multi-colored hues. It is possible to make the color composition into various different shapes and forms, and they have several different uses as well.

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.

Abstract: An antimicrobial composition containing: a component (A) that is at least one selected from the group consisting of 1,2-alkanediols having an alkyl group having 6 to 8 carbons and monoalkyl glyceryl ethers having an alkyl group having 6 to 8 carbons; and a component (B) that is at least one selected from the group consisting of tripropylene glycol, 2-methyl-1,3-propanediol, and 3-methyl-1,3-butanediol and a cosmetic containing the antimicrobial composition.

Abstract: Product for the oxidative dyeing of keratinous fibers, contained in a cosmetic carrier (A) at least one developer selected from the group of p-toluenediamine, 2-(2-hydroxyethyl)-p-phenylenediamine, N,N-bis-(2-hydroxyethyl)-p-phenylenediamine, 2-methoxymethyl-p-phenylenediamine, p-aminophenol, 4-amino-3-methyl phenol, bis-(2-hydroxy-5-aminophenyl)-methane, 4,5-diamino-1-(2-hydroxyethyl)pyrazole and their physiologically compatible salts, and (B) at least one coupler selected from the group of 1,5-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, 1-naphthol, 1,7-dihydroxynaphthalene, 2,6-dihydroxy-3,4-dimethylpyridine, 2-amino-3-hydroxypyridine, 3-amino-2-methylamino-6-methoxypyridine, 3-aminophenol, 5-amino-2-methyl phenol, 3-amino-2-chloro-6-methyl phenol, 5-(2-hydroxyethyl)-amino-2-methyl phenol, 3-phenylenediamine, 2-(2,4-diaminophenoxy)ethanol, 1,3-bis(2,4-diaminophenoxy)propane, 1-methoxy-2-amino-4-(2-hydroxyethyl)amino)benzene, 2,6-bis(2?-hydroxyethylamino)-1-methylbenzene, resorcinol, 2-methylresorcino

Abstract: The present invention relates to a composition for dyeing keratin fibres, comprising an oxidation base, a 2-amino-5-ethylphenol coupler and at least 20% by weight of fatty substance relative to the total weight of the composition. The invention also relates to a process for dyeing keratin fibres using this composition. Finally, the invention relates to the use of such a composition for dyeing keratin fibres, and in particular the hair.

Abstract: An emulsifier-free sunscreen composition includes a suspension of oil phase droplets in a gellified water phase, the oil phase droplets including a UV filter system present from at least about 20% by weight of the composition and including one or more oil soluble UV sun filters, an amino acid gelling agent and optionally at least one diol all of which oil phase components can be blended at a temperature that is below 100 degrees C.

Abstract: The disclosure relates to compositions and methods for removing semi-permanent hair dyes from hair. The compositions according to the disclosure comprise one or more anionic surfactants, one or more co-surfactants, and optionally one or more cyclic compounds. The methods comprise applying the compositions according to the disclosure to the hair.

Abstract: A hair care composition that removes calcium fatty carboxylate salts from the hair and scalp is provided. The hair care composition includes a calcium chelant, an anionic surfactant, a hydrotrope, a carrier, and optionally a zwitterionic surfactant.

Abstract: A personal care formulation comprising an emulsifier, a vegetable oil and optionally a texturizer, wherein the emulsifier contains an Acetone Insoluble (AI) component containing at least Phosphatidyl Choline (PC) and Phosphatidyl Ethanolamine (PE), wherein the emulsifier has a weight ratio R of at least 5.0.

Abstract: A composition includes polydatin and at least one photoisomerization stabilizer and a cosmetically acceptable carrier. The at least one photoisomerization stabilizer confers photostabilization to trans-polydatin by at least about 5%, relative to an otherwise identical composition without the at least one photoisomerization stabilizer.

Abstract: The present invention provides microbe-based products, as well as methods of their production and use, in oral health compositions. More specifically, the present invention provides materials and methods for enhancing and/or maintaining oral health using topical oral health compositions comprising microbial growth by-products, specifically, biosurfactants.

Abstract: The invention relates to a composition comprising at least one ceramide, at least one sphingoid base and triethyl citrate, a process for producing a formulation comprising at least one ceramide and the use of triethyl citrate for stabilization of a ceramide-containing formulation.

Abstract: Injectable compositions and methods of treating skin can help improve hydration, elasticity and/or texture of the skin. The compositions can be based on crosslinked hyaluronic acid matrices made with low molecular weight hyaluronic acids.

Abstract: Lip compositions including at least one semi-crystalline acrylate copolymer, wherein the compositions include at least two components prior to mixing and application to lips and are capable of forming a multilayer structure after application to lips, are provided.

Abstract: A bodypainting ink includes a coloring agent, a solvent, and a resin. The coloring agent includes an anion coloring agent, the resin includes a cation monomer, and a molar ratio of cations, constituting the cation monomer, to anions, constituting the anion coloring agent, is 1 or more.

Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.

Abstract: The present invention relates to a composition comprising a polymer, wherein this polymer is water-soluble and has a melting point of at least 145° C. and comprises sulfonic acid groups, and an organic amine having at least two amino groups, and optionally further cosmetic ingredients. Furthermore, the present invention relates to a process for restyling human hair comprising applying to the human hair a composition comprising a polymer, wherein this polymer is water-soluble and has a melting point of at least 145° C. and comprises sulfonic acid groups, and an organic amine, and optionally further cosmetic ingredients, thereafter heat-treating the hair, together with the composition on its surface, thereafter allowing the hair to cool down to a temperature of below 100° C., and thereafter changing the hair style by heat-treating the hair. Furthermore, the present invention relates to the use of the said polymer or of the said composition for restyling human hair.

Abstract: A cosmetic composition including component (A), which is an aqueous gelling agent represented by general formula (1) described in the specification, and a component (B), which is a polymeric thickening agent, wherein the component (A) presents a viscosity of an aqueous solution containing 1 mass % of at 25° C. of 1,000 to 5,000 mPa·s and a clouding point of the aqueous solution containing 1 mass % of component (A) of 60° C. to 80° C., and has a weight average molecular weight of 10,000 to 30,000; a method for producing the aqueous gelling agent and a method for producing the cosmetic composition are provided.

Abstract: A composition that contains powder in a dispersed state and enables the powder to rapidly disperse in water including a lipidic peptide gelator composed of at least one of compounds of the following Formula (1) or pharmaceutically usable salts of the compounds: (wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group optionally having a C1 or C2 branched chain; and R3 is a —(CH2)n—X group, wherein n is a number of 1 to 4, and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the 5-membered ring and the 6-membered ring); water; a fatty acid salt; an acidic low-molecular-weight compound; a surfactant; and powder.

Abstract: Disclosed is a cosmetic composition comprising (i) 1 to 30 wt % of a non-hydrocarbon emollient; and (ii) 2 to 60 wt % of a blend of silicone elastomer gel of the Formula (I) and solvent; wherein the solvent for the silicone elastomer gel is selected from cyclic or linear polydimethylsiloxanes; wherein the w/w ratio of the amount of the non-hydrocarbon emollient to the combined amounts of the silicone elastomer gel and said solvent is from 1:50 to 1:1 and where the amount of the non-hydrocarbon emollient is less than the amount of the silicone elastomer gel; and wherein the composition comprises less than 2 wt % capric caprylic triglycerides and less than 5 wt % crosslinked elastomeric silicone polyether, wherein said non-hydrocarbon emollient is an alkenyl or alkyl ester of a C10-20 fatty acid, an ether-ester, a polyhydric alcohol ester, a wax ester, a mono-, di- or triglyceride, a sterol ester, a fatty alcohol, a fatty acid, lanolin or its derivative, wax ester, a phospholipid, beeswax or a sterol.

Abstract: The present invention relates to a finger-moldable composition capable of forming a free-standing coating and suitable for application to, for example, human lips. The composition includes a thermoplastic block copolymer that includes styrenated blocks. It further includes a sufficient amount of cosmetic oil to allow a human user to mold the composition readily with the user's fingers and form a free-standing film.

Abstract: The present invention relates to a composition for topical application comprising at least one fatty phase; at least one volatile hydrocarbon-based oil; and at least one lipophilic polymer comprising at least hydroxyethyl acrylate units and acrylate units bearing a lipophilic group, the weight ratio of the sum of all the hydroxyethyl acrylate units to the sum of all the acrylate units bearing a lipophilic group ranging from 1:30 to 1:1 and the lipophilic polymer having a number-average molecular weight Mn ranging from 2000 to 9000 g/mol. The composition in accordance with the invention has improved sensory properties, allowing faster and more complete absorption into the skin. In particular, the composition in accordance with the invention leaves a non-greasy and non-tacky feel on the skin, during and after application, even in the presence of solid fatty substances such as waxes.

Abstract: An object is to provide a cosmetic composition that: has a high soft focus effect, a high skin beautifying effect, and a high moisture retaining effect; is safe; and enables reduction in environmental impact. Yeast cell wall particles retaining shapes of yeast cell walls and having an average particle diameter ranging from 1 to 25 ?m are prepared and blended in a cosmetic composition.

Abstract: The disclosure relates to methods of treating and/or preventing scarring that would otherwise result from an incision to an area of skin. The methods comprise administering a composition comprising tropoelastin to an area of skin that is to receive an incision and/or after the incision. It is also contemplated that the compositions may reduce scar discoloration. Methods of preventing or reducing keloid re-occurrence are also provided.

Abstract: The invention relates to an implantable device to deliver drug formulations through a nanoporous membrane. The current related arts for delivery of drug formulations include tablets, injections, implantable pellets, injectable polymer depots, and implantable infusion pumps. The invention employs a reservoir to contain the drug formulation, a nanoporous membrane, and a drug formulation with an oil.

Abstract: The invention relates to an implantable device to deliver drug formulations through a nanoporous membrane. The current related arts for delivery of drug formulations include tablets, injections, implantable pellets, injectable polymer depots, and implantable infusion pumps. The invention employs a reservoir to contain the drug formulation, a nanoporous membrane, and a formulation of estrogen.

Abstract: The invention relates to an implantable device to deliver drug formulations through a nanoporous membrane. The current related arts for delivery of drug formulations include tablets, injections, implantable pellets, injectable polymer depots, and implantable infusion pumps. The invention employs a reservoir to contain the drug formulation, a nanoporous membrane, and a formulation of testosterone.

Abstract: Methods comprising the insertion of a uterine cervical device into the lower part of the uterine cavity and endocervix for decreasing the incidence of the human papillomavirus in women, mainly types 16 and 18, thus preventing the development of uterine cervical cancer; for modifying the cervical microbiota; for increasing leukocytes and protecting against sexually transmitted infections in women.

Abstract: The use of a novel route of administration of aripiprazole for treatment of an eating disorder. Specifically, the use of an intranasal route of administration of aripiprazole for treatment of an eating disorder such as anorexia nervosa, atypical anorexia nervosa, bulimia nervosa, binge-eating disorder, purging disorder, or any combination of multiple types of eating disorders, as well as any syndrome disease such as night eating syndrome, carcinoid syndrome, or serotonin syndrome or any diseases or symptoms comorbid with an eating disorder. This intranasal route of administration will most likely reach the brain via the single epithelial cell layers of the nose to blood vessels to the cerebrospinal fluid neighboring the olfactory bulbs and finally into the nervous system where it may produce both local or systemic effects. This route may treat neurotransmitter imbalances, altered eating behaviors, or comorbid symptoms or diseases associated with an eating disorder including treatment and compliance.

Abstract: Provided herein are epinephrine spray formulations. Also provided herein are methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatment.

Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.

Abstract: The present invention provides an ophthalmic gel and a preparation method thereof. The ophthalmic gel comprises: an antibiotic; a nanocarrier, wherein the nanocarrier is used to load the antibiotic; and a biodegradable matrix, wherein the biodegradable matrix is compatible with the nanocarrier to carry the nanocarrier. When the ophthalmic gel of the present invention is applied to the surface of the cornea and conjunctiva of the eyes, the biodegradable matrix is automatically degraded and the nanocarrier carried by the biodegradable matrix will slowly release the antibiotic, loaded in the nanocarrier, at an appropriate rate to overcome the high-frequency use of general ophthalmic drugs and easily caused blurred vision; the present invention further comprises an ophthalmic gel preparation method.

Abstract: The invention relates to a method for treating or preventing nausea and vomiting. The method comprises administering an eye drop composition comprising palonosetron or a pharmaceutically acceptable salt thereof to the eye of the subject. The ocular administration results in fast systemic absorption, improved bioavailability compared to oral route and extended elimination time.

Abstract: A pharmaceutical composition comprising a muscarinic antagonist and an adenosine antagonist for topical or ophthalmic application, and ophthalmic devices containing or delivering the same, and methods of using the same, for controlling and/or reducing the progression of myopia.

Abstract: The present disclosure relates to compositions and methods for treating ocular diseases with antibiotics. In particular, the disclosure relates to non-blurring, antibiotic-containing hydrogel compositions that have an extended contact time on the eye and do not interfere with wound healing.