Abstract: An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second arrangement which can be configured to receive and modulate the at least one second radiation so as to provide at least one third electro-magnetic radiation. The optical cavity can further include a dispersive optical third arrangement which can be configured to receive and disperse at least one third electro-magnetic radiation so as to provide at least one fourth electro-magnetic radiation.

Abstract: Resonance Raman scatter is used to differentiate in quasi-real time (QRT) anomalous tissue from adjacent normal tissue. The fingerprint generated from the tissue by a 1 second pulse of 532 nm emission for approximately one second is collected and is relayed by fiber-optic to a computerized controller that determines whether the target tissue is anomalous or normal. If anomalous it is ablated. This is performed by a pattern of Resonance Raman diagnostic emission and diagnostic sensor fibers. This diagnostic/therapeutic pattern of fibers can be moved by a joystick or robotically controlled. The data received by the computer is examined instantly, and should the site be diagnosed as anomalous, the optical biopsy/ablation is repeated immediately and repeated until the site is read as normal. Novel arrays of the diagnostic and therapeutic energies ensure a 3D anomalous tissue free zone around the removal site.

Abstract: A photoacoustic apparatus includes a laser light irradiating unit that irradiates an inside of a subject with pulsed light; a photoacoustic signal acquiring unit that acquires a photoacoustic signal from a photoacoustic wave from the subject; a light amount detecting unit that detects a light amount of the pulsed light; a correlation data memory that stores first correlation data and second correlation data; an energy estimating unit that estimates an energy on the basis of the amount of the pulsed light and the first correlation data; a pulse width estimating unit that estimates a pulse width on the basis of the estimated energy and the second correlation data; and a photoacoustic signal correcting unit that corrects the photoacoustic signal on the basis of a first difference between the estimated energy and a reference energy and a second difference between the estimated pulse width and a reference pulse width.

Abstract: A sensor that detects a heart rate and/or a blood oxygen content includes a radiation source and a photodetector, wherein the radiation source includes a light-emitting diode array, the light-emitting diode array includes a plurality of emission regions, the emission regions each include a first light-emitting diode and a second light-emitting diode, the first light-emitting diode includes a first wavelength, the second light-emitting diode includes a second wavelength, and a distance between the first light-emitting diode and the second light-emitting diode within the emission regions is 100 micrometers or less.

Abstract: Wearable thoracic element for detecting, monitoring and reporting the physiological status of an individual. The thoracic element, in the shape of a band, comprises a support layer (5) including a first and second sensors (1),(2) and a processing unit (3) inside a casing (8). The first sensor (1) is a laminated strain gauge located on an elastic portion (5c) of the support layer (5) and the second sensor (2) is formed by a first and a second laminated electro-conductive elements (2a), (2b) cooperating to obtain an ECG measurement, Each of the sensors (1), (2) includes at their ends a connector (21a, 21b, 11a, 11b) to be attached to terminals (4a), (4b) of the casing (8). The laminated electro-conductive elements are superimposed and separated by an electric insulating rigid laminar layer (6). The support layer has two openings (5a) and (5b) at a given distance, through which the electro-conductive elements (2a and 2b) can contact the skin of the individual.

Abstract: In some examples, determining a heart failure status using a medical device comprising one or more sensors includes determining a first value of a heart beat variability metric of a patient while an activity state of a patient satisfies an inactivity criterion based on a signal received from the one or more sensors, and determining, within a predetermined period of time after further determining that the activity state of the patient no longer satisfies the inactivity criterion, a second value of the heart beat variability metric while the activity state of the patient no longer satisfies the inactivity criterion based on the signal. A difference between the first value of the heart beat variability metric and the second value of the heart beat variability metric may be determined and the heart failure status of the patient may be determined based on the difference.

Abstract: A blood pressure measurement device includes an outer case; a base; a pump provided on a surface of the base such that the pump is shifted from a center of the outer case and located on one side as viewed in a circumferential direction of a living body; a first pressure sensor and a second pressure sensor that are provided such that the first pressure sensor and the second pressure sensor are arranged side by side in the circumferential direction and located on one side as viewed in a direction orthogonal to the circumferential direction; and a first on-off valve and a second on-off valve that are provided such that the first on-off valve and the second on-off valve are arranged side by side in the circumferential direction with reference to the first pressure sensor and the second pressure sensor.

Abstract: The combination of skin-contacted stimulation together with capillary blood flow monitoring is applied in a tandem, coordinated fashion in an integrated system and method to provide early detection of compromised circulation conditions, to provide data useful for prescribing therapeutic treatments including stimulation therapies, and to monitor the effectiveness of various treatments. The disclosed methods and system can apply to a broad spectrum of diagnosed and/or undiagnosed vascular diseases and extend to detection and treatment of limb or appendage injury. An integrated device which can be a portable or a wearable product which makes use of the new system and method is disclosed.

Abstract: A system for monitoring the cardiopulmonary functioning of a person includes a remote terminal and a sensor module configured to be worn by the person. The sensor module includes at least one physiological sensor configured to sense the following types of physiological information generated by the person: pulse rate, blood flow, and blood pressure; at least one signal processor configured to process signals generated by the at least one physiological sensor; and at least one transmitter responsive to the at least one signal processor that is configured to transmit at least one signal to the at least one remote terminal. The at least one signal processor is configured to focus processing resources on one of the types of physiological information in response to a specified preference by the person.

Abstract: An electronic device includes a base and a meter that can be displaced along a plane intersecting a surface of the base. The meter includes an arm that can be displaced in a direction approximately parallel to a displacement direction of the meter, and a sensor capable of detecting displacement of the arm in accordance with the pulse wave.

Abstract: An apparatus includes a first pulse wave sensor and a second pulse wave sensor that can be arranged in correspondence with respective measurement sites distant from each other. The first pulse wave sensor outputs a current signal having a first frequency to a measurement site and detects a voltage signal that represents pulse waves from the measurement site, based on a filter characteristic corresponding to the first frequency. The second pulse wave sensor outputs a current signal having a frequency different from the first frequency to a corresponding measurement site and detects a voltage signal representing pulse waves from the measurement site, based on a filter characteristic corresponding to a second frequency.

Abstract: A system for determining a pulse wave velocity comprises a body lumen insertable device with an actuator for providing a pulse in the vicinity of a vessel wall and a sensor for sensing arrival of the pulse. A pulse wave velocity is obtained from the time difference between actuation of the actuator and sensing of the pulse. This system is used to create an artificial pulse which is transmitted along a vessel by a known distance before detection by a sensor.

Abstract: The blood pressure measuring device includes a device main body configured to form a flow path of a fluid and supply the fluid, and a cuff to be wound around a living body, the cuff provided with a bag-shaped connection portion with an opening and a connection plate with a hole communicating with the opening; the connection portion formed of a sheet member; the connection plate having a bending elastic modulus higher than that of the connection portion, bonded to the connection portion and adhered to the device main body; and the cuff configured to be inflated when the fluid is supplied to an internal space of the cuff.

Abstract: A blood pressure measurement device includes: a case including an outer case, a base housed in the outer case, and a back cover that covers an opening of the outer case; a movable portion arranged in a gap between the outer case, the base and the back cover, and including a bag-shaped cuff that inflates when a fluid is supplied to an internal space; and a seal member that is formed of a gel body having a lower elastic modulus than that of the cuff, and that is provided in the gap to seal the gap.

Abstract: A pulse diagnostic device and a system of pulse diagnosis are provided. The pulse diagnostic device includes a cuff and a main monitor. The cuff includes a tube and an air bag arranged with an air path interface. A gas medium is received in the air bag. The tube is connected to the air path interface. The main monitor includes a pressure sensor and a controller. The tube extends to reach the main monitor and is connected to the pressure sensor, and the pressure sensor further connects to the controller. When the pulse diagnostic device is working, the cuff contacts an artery, the pressure sensor senses a pressure of the gas medium in the tube. The pressure sensor transmits the pressure of the gas medium to the controller. The controller obtains the pulse information and the blood pressure information based on the pressure of the gas medium.

Abstract: A blood pressure measurement device includes: a base; a flow path cover that is fixed to the base and defines a flow path portion with reference to the base; a recess including an outer surface which is on a base side of the flow path portion and part of which is projected toward the base, and an outer surface which is on a side opposite to the base side and part of which is depressed toward the base; a nozzle that is that is formed on a bottom surface of the recess and communicates with the flow path portion; and a bag-shaped cuff that is connected to the nozzle and that is inflated when a fluid is supplied to an internal space.

Abstract: There is described a method for evaluating a heart rate variability comprising: receiving an electrocardiogram representing an electrical activity of a heart; determining a modulation spectrum for the electrocardiogram, the modulation spectrum comprising a plurality of per-frame modulation spectrograms each representing a frequency as a function of a modulation frequency; for each per-frame modulation spectrogram, determining a respective central modulation frequency; determining an indication of the heart rate variability using the determined respective central modulation frequencies for the per-frame modulation spectrograms, a mean central modulation frequency and the number of per-frame modulation spectrograms; and outputting the indication of the heart rate variability.

Abstract: The invention provides a physiological parameter sensing system (50) and method in which physiological information indicative of at least one physiological parameter is derived. The approach of the invention is based on constructing multiple pulse signals from different weighted combinations of at least two detection signals, derived from detected electromagnetic radiation directed onto or through a subjects skin region. The weightings are based on different of a set of various blood volume pulse vectors. A quality indication value is derived for each generated pulse signal, where this is based on a derived relationship between an obtained heart rate signal for the patient and the pulse signal. The blood volume pulse vector resulting in the pulse signal having the highest quality indicator value and/or from the derived pulse signal itself is used to derive the physiological parameter information.

Abstract: A physiological data detection method is provided. The physiological data detection method includes the following steps. Firstly, an ECG signal and a PPG signal are detected. Then, a plurality of RRI values is calculated according to the ECG signal, and a plurality of PPI values is calculated according to the PPG signal. Thereafter, wrong RRI values are excluded according to the RRI values and/or the PPI values. Then, whether an abnormal state occurs or not is determined by using the remaining RRI values. A wearable device therefor is also provided.

Abstract: A method for detecting disease using a manometry includes obtaining pressure values from each of the plurality of pressure sensors during a pre-set time, obtaining a three-dimensional pressure distribution showing the changes in the pressure values according to location and time by using the time, the pressure values, and locations in which the pressure sensors are disposed within the arbitrary location section, and calculating the volume integral value of the interest location which is predetermined in accordance with the disease, in the three-dimensional pressure distribution.

Abstract: A modified nerve cuff electrode is designed to enhance the stability of neural recording and/or nerve stimulation. Any nerve cuff electrode includes a nerve cuff and a plurality of electrodes within the nerve cuff. While traditional nerve cuff electrodes have every one of the plurality of electrode contacts on the inner surface of the nerve cuff, in the modified nerve cuff electrode each of an inner surface and an outer surface of the nerve cuff has at least one electrode contact. The at least one electrode contact on the outer surface can be electrically isolated from the peripheral nerve to provide a stable reference or ground during recording or a stable pathway for a return current during stimulation to enhance the stability of the recording or the stimulation.

Abstract: Stimulation and recording electrode assemblies that are particularly useful for Automatic Period Stimulation (APS). Such embodiments are compatible with nerve monitoring systems to provide continuous stimulation of a nerve during surgery. Certain embodiments include an electrode assembly having cuff including a body and two ears extending from the body. Within the body, at least one electrode is supported and connected to a lead wire assembly. The ears can be brought together to enlarge a gap in the body so that the electrode assembly can be fixated around a nerve. Other embodiments include an electrode assembly including first and second needle electrodes that each have a tip. A body is provided to interconnect the needle electrodes and can be manipulated to move the tips either toward or away from one another. Disclosed embodiments provide nerve monitoring and stimulation in cases where the nerve is only partially dissected.

Abstract: Stimulation and recording electrode assemblies that are particularly useful for Automatic Period Stimulation (APS). Such embodiments are compatible with nerve monitoring systems to provide continuous stimulation of a nerve during surgery. Certain embodiments include an electrode assembly having cuff including a body and two ears extending from the body. Within the body, at least one electrode is supported and connected to a lead wire assembly. The ears can be brought together to enlarge a gap in the body so that the electrode assembly can be fixated around a nerve. Other embodiments include an electrode assembly including first and second needle electrodes that each have a tip. A body is provided to interconnect the needle electrodes and can be manipulated to move the tips either toward or away from one another. Disclosed embodiments provide nerve monitoring and stimulation in cases where the nerve is only partially dissected.

Abstract: A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. The stimulation electrode may be a connection or self-contained component to contact a portion of a nerve. The stimulation electrode may provide or receive a signal to and/or from the nerve to assist in testing integrity of the nerve.

Abstract: An exemplary wearable sensor unit includes 1) a magnetometer comprising a vapor cell comprising an input window and containing an alkali metal, and a light source configured to output light that passes through the input window and into the vapor cell along a transit path, and 2) a temperature control circuit external to the vapor cell and configured to create a temperature gradient within the vapor cell, the temperature gradient configured to concentrate the alkali metal within the vapor cell away from the transit path of the light.

Abstract: A system including a medical device is provided. The medical device includes at least one sensor configured to acquire first data descriptive of a patient, first memory storing a plurality of templates, and at least one processor coupled to the at least one sensor and the first memory. The at least one processor is configured to identify a first template of the plurality of templates that is similar to the first data, to determine first difference data based on the first template and the first data, and to store the first difference data in association with the first template. The system may further include the programmable device.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart.

Abstract: A catheter is described with an end effector having densely arrayed electrodes on three loops which are arrayed in various planar configurations when the end effector is unconstrained. The end effector has first, second and third loop members, each loop member includes two spines and a connector that connects the two spines to define a loop extending away from a tubular member of the catheter such that the first, second and third loop members are configured so that each connector of each of the first, second and third loop members is in contact with only one connector of the adjacent loop member.

Abstract: There is provided a system (100) and method for determining a water or lipid level of skin. The system (100) comprises at least two electrodes (108) suitable for contacting skin, and a signal generator (106) configured to generate an electrical signal at a frequency across the at least two electrodes (108). The system (100) is configured to measure a conductivity between the at least two electrodes (108). The system (100) is further configured to determine a water or lipid level of skin based on the measured conductivity and the frequency of the electrical signal.

Abstract: The present disclosure is directed to measuring impedance across a plurality of electrode pairs. The disclosed systems and methods may simultaneously provide drive signals between electrode pairs and then sense the voltage signals that develop at the electrodes. Digital signal processing may be used to synchronously demodulate the voltage signal at each electrode to determine impedances at the electrodes. Each electrode pair may be driven at a unique frequency to allow for significantly increasing a number of electrode pairs and/or increasing drive current magnitudes. Synchronous demodulation allows the unique frequencies to be detected independent of each other while minimizing crosstalk. Typically, the drive frequencies are made orthogonal by setting the drive frequencies at harmonics of a common base frequency and measuring a response over an integer number of cycles.

Abstract: A method of detecting increasing fluid in a lung of a subject, the method comprising: at a first time, determining a first difference between a time of arrival of a first feature of a received electrical signal of a subject's heart beat and a time of arrival of a second feature of a received acoustic signal of the subject's heart beat; at a second later time, determining a second difference between a time of arrival of the first feature of a received electrical signal of a subject's subsequent heart beat and a time of arrival of the second feature of a received acoustic signal of the subject's subsequent heart beat; and if the second difference is less than the first difference by more than a threshold value, producing a fluid detection alert.

Abstract: In vitro methods for diagnosing, prognosing and/or monitoring neutrophilic or eosinophilic airway inflammation in a subject, comprising determining the amount of one or more volatile organic compounds (VOCS) in exhaled breath from said subject. The invention also provides devices for use of said methods.

Abstract: A method and system detects a hypoxic condition during an obstruction of an airway of a subject to detect and treat obstructive sleep apnea (OSA) in the subject. The method and system includes an organ stimulating transducer configured for placement in a vicinity of an organ of the subject to stimulate the organ and remove the obstruction when OSA is detected.

Abstract: Methods of using isotopic biomarkers in determining the efficacy of a treatment for an organic acidemia in a subject are disclosed herein. Methods of using isotopic biomarkers in determining the efficacy of a liver-directed treatment for an organic acidemia in a subject are likewise disclosed herein.

Abstract: The present disclosure relates to methods and systems for estimating an efficiency of lungs of a patient receiving respiratory care. A blender has a primary input port for receiving a first gas to be delivered to the patient and one or more secondary input ports for receiving a second gas to be delivered to the patient from one or more gas sources. A patient-side port of the blender delivers the first and second gases to the patient. A gas composition sensor measures a fraction of the first gas and a gas flow sensor measures a flow of the first gas. A controller causes a sequential delivery of the first and second gases to the patient and estimates a functional residual capacity of the patient based on measurements from the gas composition sensor and from the gas flow sensor. The controller may also estimate a cardiac output of the patient.

Abstract: Methods, systems, and devices for measuring respiratory parameters from an ECG device are described. The method may include receiving an electrocardiogram (ECG) signal associated with a patient. The method may further include detecting a change in modulation of the ECG signal between a first portion of the ECG signal and a second portion of the ECG signal. The method may further include determining a change in respiratory effort of the patient based at least in part on the change in modulation.

Abstract: Systems and methods for detecting lameness in a limb of an animal are described herein. In an embodiment, a lameness detection system comprises a plurality of wearable footwear elements. Each of the footwear elements comprises a housing that is configured to fit snugly on a paw of the animal during ordinary gait. Each of the footwear elements comprise a sensor or matrix of sensors that is configured to detect and generate data representative of pressure or force exerted by the paw on a ground surface. Each footwear element additionally comprises a wireless transceiver that is configured for short-distance communication of the data captured by the sensors. The system further comprises a computing device with a wireless transceiver configured to communicate with the transceivers of the footwear elements and instructions which, when executed by the computing device, cause the computing device to analyze lameness in a limb of the animal based on data received from the sensors.

Abstract: The present invention relates to a detachable volume measuring apparatus and a tissue expansion apparatus comprising same, and provides, according to one aspect of the present invention, a volume measuring apparatus which is mounted to a tissue expansion apparatus comprising a suction apparatus for generating negative pressure inside a dome, the volume measuring apparatus comprising: a housing having an inlet into which outside air flows, and an outlet for supplying the outside air to the suction apparatus; a flow line for connecting, in the housing, the inlet and the outlet; first and second pressure sensors respectively provided at two different locations on the flow line; and a control unit for outputting, to the suction apparatus, pressure information measured from the first and second pressure sensors.

Abstract: A method for monitoring the progress of post-operative ambulation is disclosed. A patient after a surgical procedure such as an operation is provided with an ambulatory routine. The ambulatory routine is monitored using a wearable biosensor device operable to track steps of the patient. The steps of the patient in following the ambulatory routine are recorded. The ambulation data is displayed on a periodic basis to provide feedback to both the patient and health care professionals.

Abstract: Systems and methods for remotely sensing movement of a mammalian subject utilize a radio frequency (RF) transmitter configured to impinge a RF signal on tissue of a mammalian subject, a RF receiver configured to receive a reflected RF signal, a processor configured to separately identify presence of respiratory and non-respiratory motion of the mammalian subject, and a memory configured to store processes signal values generated by or derived from the processor, wherein the processor is configured to compare one or more processed signals against one or more stored processed signal values, and detect a health state or health condition of the mammalian subject. Sleep apnea and respiratory events may be detected. In one embodiment, motion of a human infant may be mapped over time, and motion trends may be used to assess proper development of the infant.

Abstract: The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.

Abstract: Systems and methods are provided for determining an acceleration at a location of interest within one of a user's head and neck. At least one of linear acceleration data, angular acceleration data, angular velocity data, and orientation data is produced using at least one sensing device substantially rigidly attached to an ambient-accessible surface of the user's head. The location of interest is represented relative to a position of the at least one sensing device as a time-varying function. An acceleration at the location of interest is calculated as a function of the data produced at the sensing device and the time-varying function representing the location of interest. The calculated acceleration at the location of interest is provided to at least one of the user and an observer in a human-perceptible form.

Abstract: A system and method for determining a patient force during a motion includes a tether adapted to be biased during a motion so that a tension force is applied. The tether is connected a motor and generates a tether force about the motor. The system controls the motor by generating a motor torque in a direction opposite the tether force. A recording module stores the motor torque at a plurality of intervals during the motion and a position of the tether. A display module generates a plot of a position of the patient versus a force generated by the patient. The position of the patient corresponds to the cumulative rotation of the shaft in the first direction about the axis of rotation of the shaft at each of the intervals. The force generated by the patient corresponds to the amount of motor torque at each of the intervals.

Abstract: Herein disclosed is a system that may be implemented within a headphone to facilitate hearing testing. Implementation of the system in the headphone may include implementation of tone generation circuitry and sound pressure level measurement circuitry being implemented in the headphone limiting the amount of calibration for accurate measurement when performing a hearing test.

Abstract: The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.

Abstract: There is provided a device, system and method for continuously monitoring a physiological condition such as diabetes in a body. The disclosed method comprises detecting a variation in capacitance value of a sensor coil when the sensor coil is placed in vicinity of the body and displaying the detected variation on a display unit, wherein the sensor coil has a fixed inductance value. The display unit is further integrated with a communication unit for communicating a monitored physiological condition in the body with an external communicating unit. The proposed device is non-invasive and in a form of a wearable.

Abstract: A personalized bio-information correcting apparatus includes a communication interface configured to acquire original bio-information value data of a user, and a processor configured to obtain a personalized bio-information guideline, based on a personalized physiological model, identify whether at least one value among the acquired original bio-information value data is an outlier, based on the obtained personalized bio-information guideline, and based on the at least one value among the acquired original bio-information value data being identified to be the outlier, obtain final bio-information value data by correcting the at least one value among the acquired original bio-information value data.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte, such as blood glucose. An inserter having a retractable introducer is provided for subcutaneously implanting the sensor in a predictable and reliable fashion.

Abstract: A pulse oximetry system for reducing the risk of electric shock to a medical patient can include physiological sensors, at least one of which has a light emitter that can impinge light on body tissue of a living patient and a detector responsive to the light after attenuation by the body tissue. The detector can generate a signal indicative of a physiological characteristic of the living patient. The pulse oximetry system may also include a splitter cable that can connect the physiological sensors to a physiological monitor. The splitter cable may have a plurality of cable sections each including one or more electrical conductors that can interface with one of the physiological sensors. One or more decoupling circuits may be disposed in the splitter cable, which can be in communication with selected ones of the electrical conductors. The one or more decoupling circuits can electrically decouple the physiological sensors.

Abstract: The present application discloses a multi-spectral fundus imaging system and method using dynamic visual stimulation, where the imaging system includes: a multi-spectral light source capable of emitting multiple different wavelengths; a mid-pass mirror being a reflecting mirror with a central hole penetrating the reflecting mirror; an imaging focusing lens group; an image acquisition device; and a controller configured to control the multi-spectral light source and the image acquisition device to work synchronously; a pattern sent by the optical stimulation device is transmitted to the fundus through the image focusing lens group and the central hole of the mid-pass mirror in sequence; an imaging light reflected from the fundus passes through the central hole of the mid-pass mirror and the imaging focusing lens group in sequence; the image acquisition device acquires the image to complete a multi-spectral fundus image acquisition.