Abstract: Modular automated dispensing systems for dispensing secured medications in a medical environment are provided. The system includes a compact enclosure configured to be disposed in a medical treatment area without taking up valuable floor space. The system includes lockable drawers having one or more compartments for storing and dispensing medications or medical supplies. The system is unlocked by use of an access control interface internally or externally connected directly to the system, or networked to the system through a medical center network.

Abstract: A pill dispensing apparatus includes a carousel with at least one removable bin for storing pills, a vision system for identifying pills within the bin, a vacuum nozzle for removing one or more pills identified by the vision system, and a dispensing area for receipt of the removed pills.

Abstract: An aerosol mist compliance device maintains a patient's aerosol supply and monitors the patient's access to pills contained in the device to memorialize the patient's compliance with his/her respiratory inhalation regimen. The device has a housing, including an inner aerosol mist storage compartment and an electronics unit, a removable mouthpiece cap, a switch to detect removal of the mouthpiece cap and magnet away from the housing, and to detect a replacement of the mouthpiece cap and magnet to the housing, wherein activating the switch triggers a transition from an active state, to a dormant state, and vice versa. A transition from the dormant state to the active state, by replacing the mouthpiece cap to the housing generates an aerosol-taken signal. A microcontroller generates a compliance notification signal that is communicated to a Wi-Fi module or router within or attached to the electronics unit, to memorialize the apparent compliance.

Abstract: A device for preparing a beverage comprises a bottle, which includes the teat, a container, and a heating chamber. The bottle nests within the heating chamber and the container is connected to the neck of the bottle. At the bottom of the heating chamber is a heating element and an electrical circuit and all required elements for heating a bottle in the heating chamber. The heating chamber provides instant or constant heating of fluid in the bottle. Preparation of the beverage may include detaching the bottle from the heating chamber, opening the container to allow powder to drop into the bottle with the fluid, and shaking the bottle to dissolve the powder in the fluid.

Abstract: Disclosed is a disposable container that includes a body portion, a sealing collar, a nozzle, and a sealing disc. The body portion is having a threaded neck formed from the body portion. In an aspect, the body portion is made of a laminated material. The sealing collar adapted to detachably attached with the body portion. The nozzle is removably fixed to the body portion with the sealing collar adapted to be screwed on to the threaded neck. The sealing disc disposed between the sealing collar and the nozzle to stop the flow of a beverage to the nozzle.

Abstract: A baby pacifier having a means to sense when it is dropped from an infant's mouth. The invention being comprised of a conventional, flexible pacifier with an onboard drop sensor therein. When the pacifier is dropped and contacts the ground or floor, the device senses the resulting vibration and sends a small audible sound along with a flash from a light emitting diode (LED) to notify the parent it has been dropped. Other embodiments of the invention can include different forms of notifications when they are dropped—for example, some can vibrate; some can activate when hearing a parents voice, a baby's cry, or to clapping. Still other embodiments allow parents to customize their own sound notifications when the device is dropped. An object of the invention is to minimize lost pacifiers by getting a parent's attention when the pacifier falls from an infant's mouth so they can recover it.

Abstract: Provided herein are novel instruments for oral engagement with mammals (e.g., toddlers, pets, or people with special needs), such as for relieving infant or toddler sucking stress (e.g., pacifiers, teething rings, and pet toys), which contain an adhesive material positioned in an interior area of the instrument and that allows the instrument to be securely attached to a support device comprising a counter-adhesive material with a strength that maintains the suspended position of the instrument (prevents falling), but also releases to the instrument upon application of a manual physical force (e.g., pull) of the user; as well as related systems and methods.

Abstract: A dental adhesive composition, having a solvent which is an azeotrope of methyl ethyl ketone with water. Optionally, the azeotropic solvent may comprise in addition, ethanol or isopropanol. The boiling point of the solvent is less than 75° C.

Abstract: The present invention relates to a dental composition comprising a radically polymerizable compound, a redox initiator system comprising one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the host molecule is selected from cyclodextrines, crown ethers, cucurbituriles and calixarenes and the one or more guest molecules are reducing agents, and an oxidizing agent. Furthermore, the present invention relates to a use of the redox initiator system in a dental composition.

Abstract: The invention relates to a process of producing a dental zirconia restoration, the dental zirconia restoration having an outer and an inner surface, the process comprising the step of firing a porous dental zirconia restoration and a glass until the porous dental zirconia restoration is sintered, the glass being located during the firing step on at least a portion of the outer surface of the porous dental zirconia restoration, wherein the zirconia material of the porous dental zirconia restoration and the glass are selected such that during the firing step the glass infiltrates the pores of the porous dental zirconia restoration to an extent of not more than 5 ?m in depth. The invention also relates to a sintered dental zirconia restoration obtainable by such a process and a kit of parts comprising a porous dental zirconia mill blank and a surface treating agent containing a glass for use in such a process.

Abstract: A dissolvable fibrous solid shampoo article containing fibrous elements. The fibrous elements can contain a polymeric structurant, a surfactant, and optionally a cationic polymer. The fibrous article is substantially free of lamellar structures and can have a hand dissolution of less than 15 strokes.

Abstract: The present invention is directed to a tissue including a cellulosic substrate having a gel softener disposed on the substrate. The gel softener is a contact product of a gelator and a pharmaceutically or cosmetically acceptable oil. Further, the gel softener is sprayable at a temperature above room temperature and is in a solid or semi-solid state upon contact with the substrate at room temperature.

Abstract: [Object] The present invention relates to leave-off type or leave-on type solid form cosmetics, and provide solid form cosmetics that are excellent in cleansing or skincare performance and has high transmittance. [Solution] A solid form cosmetic comprising a gelling agent comprising dibutyl lauroyl glutamide and/or dibutyl ethyl hexanoyl glutamide, oil agent, surfactant and water. A solid form cosmetic, wherein the oil agent is a hydrocarbon oil, an ester oil having no hydroxy group, and/or a silicone oil which is not nonpolar.

Abstract: [Object] To provide a decorative aqueous composition that includes particles formed from opal-type colloidal crystals uniformly and stably dispersed in an aqueous dispersion medium, and exhibits a structural color due to interference of light, and to provide a method for producing the decorative aqueous composition. [Solution] The decorative aqueous composition of the present invention contains particles of opal-type colloidal crystals dispersed in an aqueous dispersion medium in which a polymer is dissolved. The particles of the opal-type colloidal crystals are made from hydrophilic colloidal particles having an average particle diameter ranging from 10 nm to 1000 nm with a variation coefficient of the particle diameter being within 20%. Therefore, the decorative aqueous composition of the present invention contains opal-type colloidal crystals uniformly and stably dispersed in an aqueous dispersion medium, and exhibits a structural color due to interference of light.

Abstract: The present invention relates to a composition comprising (a) at least one microcrystalline cellulose; (b) at least one nonionic surfactant of ester type; (c) at least one surfactant of alkylpolyglycoside type; (d) at least one polysaccharide hydrophilic gelling agent other than the ingredient (a); (e) at least one oil; and (f) water. The composition according to the present invention has good sprayability and stability, and can provide a smooth skin finish.

Abstract: A surfactant-free cosmetic composition is disclosed. The composition is a stable water in silicone oil (W/S) formulation containing a silicone oil phase portion and an aqueous phase portion, wherein the silicone oil phase portion contains an emollient a pyrrolidone carboxylic acid group, oil-absorbing powder and silicone oil, and the aqueous phase portion contains 50 wt. % or more of water based on the total weight of the surfactant-free cosmetic composition. The composition may further contain a high content of vitamin C or a vitamin C derivative and has improved long term storage stability.

Abstract: An oral care composition with tin, polyol with five or more carbon atoms, water, and a pH of greater than 7. An oral care composition with a tin ion source, a fluoride ion source, a polyol with five or more carbon atoms, water, and a pH of greater than 7. Oral care compositions with a high tin ion availability.

Abstract: A dentifrice composition with tin, calcium, and a pH of greater than 7. A dentifrice composition with tin, fluoride, calcium abrasive, water, and a pH of greater than 7. Dentifrice compositions with a high tin ion availability. Dentifrice compositions comprising stannous fluoride and/or stannous chloride in combination with calcium carbonate.

Abstract: An oral care composition with a tin, polyol with five or six carbon atoms, polyol with seven or more hydroxyl functional groups, and a pH of greater than 7. An oral care composition with a tin ion source, a fluoride ion source, a polyol with five or six carbon atoms, a non reducing sugar or sugar alcohol with seven or more hydroxyl functional groups, and a pH of greater than 7. Oral care compositions with a high tin ion availability.

Abstract: The present invention is directed toward a skin protection composition and method of use, for skin protection against extreme temperatures. The present disclosure teaches a silica-based composition applied to skin prior to extreme temperature exposure to protect skin from said exposure. The composition is formulated into a variety of topically-applied compositions and means for dispensing said compositions.

Abstract: The present invention relates to a water-releasing stick-type cosmetic and, specifically, to a water-releasing stick-type cosmetic containing: an oily portion; and a water-releasing ingredient that is spread out in the oily portion, wherein the water-releasing ingredient has water particles encompassed by a plurality of plate-shaped materials to which emulsifiers are bound. According to the present invention, provided is a water-releasing stick-type cosmetic, which can provide a moist and cool feeling by directly supplying a large quantity of water, has excellent dosage form stability by having a hardness suitable for stick cosmetics, and simultaneously has excellent application texture, excellent storage stability and excellent color tone.

Abstract: This invention relates to oral care compositions comprising a first source of stannous, a second source of stannous, wherein the second source of stannous contains stannous pyrophosphate, and a zinc source selected from the group consisting of: zinc oxide, zinc citrate, zinc lactate, and combinations thereof, as well as to methods of using and of making these compositions.

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

Abstract: The present invention discloses a personal care composition comprising: (a) A polyvalent metal salt of pyrithione; (b) A metal complex selected from the group consisting of: wherein Y1, Y2, Z1, Z2 are selected from the following groups: —NH2, —NHR11, —NR12R12, —NHCO—R20, —SH, —OR13, —O(C?O)—, phosphate. and wherein at least one of Y1 and Z1 of compound I is —SH, and wherein at least one of Y2 and Z2 of compound II is —SH R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, can independently be H, alkyl, substituted alkyl, phenyl, aryl; R14 is —NH2, —NHCO—CH3, —NHR17, or —NR18R18 R15 is —COOH, —COOR19 R11, R12, R13 R16, R17, R18, R19 can be independently be alkyl, substituted alkyl, phenyl, aryl. and wherein the metal of the complex is selected from the group consisting of zinc, copper, and iron.

Abstract: An elastomer improves the feel of inorganic powder on the skin. An emulsion cosmetic is characterized by containing: (A) 0.5-20 mass % of an inorganic powder having an elastomer coating layer containing (a1) and (a2); and (B) 20-80 mass % of an oil component. The elastomer is characterized by comprising: (a1) a silicone polymer having an amino group; and (a2) a carboxyl group-containing silicone polymer or a carboxyl group-containing acrylic polymer, wherein the molar ratio of the amino group to the carboxyl group, Y/X is in the range of 0.1-1.2 (Y is the molar amount of the carboxyl group contained in the component (a2), and X is the molar amount of the amino group contained in the component (a1)).

Abstract: A cosmetic ink composition comprises a particulate material, a polymeric dispersant having a weight average molecular weight of less than about 20,000 daltons, and a polymeric rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The cosmetic ink composition can undergo controlled syneresis, forming a weak colloidal gel phase and a particle-lean, low viscosity phase, which can be printed without interventions such as agitation, mixing, or re-circulation to homogenize the composition.

Abstract: The present invention provides compositions, methods and kits for treating skin, which combine administration of a substituted resorcinol and infrared light having a peak wavelength of about 750 nm to about 1000 nm.

Abstract: The invention relates to a composition comprising, in a physiologically acceptable aqueous medium, 4-(3-ethoxy-4-hydroxyphenyl)-2-butanone and a solvent with solubility parameters in the Hansen solubility space such that 14.5<?a<30 and 15<?d<22. Use for caring for, making up and cleansing keratin materials.

Abstract: Described herein, a water-soluble personal cleansing product including a water-soluble fibrous structure; wherein the water-soluble fibrous structure comprises a plurality of fibrous elements; wherein the plurality of fibrous elements comprises one or more fibrous element-forming materials comprising one or more polyvinyl alcohols; and one or more active agents present within the plurality of fibrous elements, wherein the one or more active agents comprise one or more surfactants, wherein the one or more surfactants comprise at least one glutamate surfactant according to the general formula (I): wherein R1 is a saturated or unsaturated, straight or branched alkyl or alkenyl chain with from 5 to 20 carbon atoms; and M is H, ammonium, triethanolammonium (TEA), sodium or potassium and mixtures thereof; and wherein the water-soluble fibrous structure is substantially free of alkyl sulfate and alkyl ether sulfate type of surfactants.

Abstract: The purpose of the present invention is to provide a transparent solid cosmetic that colors when applied to the skin. A transparent solid cosmetic that changes color after application, wherein the transparent solid cosmetic includes two or more amino-acid-type gelling agents including dibutyl lauroyl glutamide (GP-1) and dibutyl hexanoyl glutamide (EB-21), and has a transmittance of 50% or higher.

Abstract: The use of a component for strengthening keratinous fibres or protecting keratinous fibres from damage, wherein the component is an ester of a certain oxalkylated alkylalkylene diamine and/or a quaternized salt thereof.

Abstract: The present application provides a method for preparing a hydrogel and the obtained hydrogel. The method including: forming a first part by mixing a first single-stranded nucleotide with a first liposome, and forming a second part by mixing a second single-stranded nucleotide with a second liposome, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends; forming a hydrogel by mixing the first part and the second part.

Abstract: The present invention provides topical compositions comprising a combination of an N-acyl dipeptide derivative and glycolic acid. The compositions provide enhanced penetration of the N-acyl dipeptide derivative into the skin.

Abstract: A cosmetic composition, comprising osteogenic growth peptide carbon-terminal pentapeptide, and at least one of a carrier, a diluent and an adjuvant. The cosmetic composition can promote the proliferation of fibroblasts and the synthesis of skin collagen, and also has the effects of promoting skin wound healing, and eliminating swelling and inflammation.

Abstract: In some embodiments, an anti-aging composition includes hyaluronic acid, at least one anti-aging peptide, at least one skin penetration enhancer, and water. In some embodiments, an anti-aging composition includes hyaluronic acid, at least one anti-aging peptide, at least one tensing polymer, and water. An anti-aging product includes a skin mask patch and an anti-aging composition loaded into the skin mask patch. A method of forming an anti-aging product includes forming an anti-aging composition and loading the anti-aging composition into a skin mask patch.

Abstract: A human growth hormone fusion protein has enhanced thermal stability. The human growth hormone fusion protein has the amino acid sequence SEQ ID NO: 3 or SEQ ID NO: 4. A gene encoding the human growth hormone fusion protein has E. coli codon-optimized nucleotide sequence of SEQ ID NO: 5 or SEQ ID NO: 6. A recombinant vector includes the aforementioned gene. A host cell is transformed with the aforementioned recombinant vector. A method for producing in a host cell a human growth hormone fusion protein includes transforming a host cell with the aforementioned recombinant vector. The human growth hormone fusion protein may improve skin wrinkle and maintain skin elasticity. As the human growth hormone fusion protein has thermal stability and also has an effect of improving skin wrinkle and increasing the effect of maintaining skin elasticity, it can be advantageously used as a raw material of cosmetics.

Abstract: The invention provides a method of applying rat tail collagen in the field of cosmetics. Compared with the conventional collagen on the market currently, in addition to having the characteristics of general collagen, the rat tail collagen still has the advantages of a stable triple helix structure, high collagen activity, low immunogenicity, controllable quality of the source and high biological safety, so radiation sterilization which lowers the biological activity of the collagen may not be needed. As determined from the experiment, the rat tail collagen prepared by the technical solution provided by the present invention has the properties of whitening skin, inhibiting melanin synthesis, resisting oxidation and allergy, repairing hormone skin and removing acne. The method provided by the present invention also overcomes the technical drawbacks that the collagen-contained cosmetics usually have.

Abstract: Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for inhibiting activation of PAR2 in skin by utilizing a synergistic combination of a water lily extract and vitamin B3 compound. The method involves treating hyperpigmented skin by applying a skin care composition containing an effective amount of a combination of water lily extract and vitamin B3 compound to a target portion of skin over the course of a treatment period.

Abstract: Processes condition human hair by applying an aqueous composition onto the human hair such that the conditioned human hair achieves long lasting conditioning of the human hair and increasing hair temperature of the conditioned human hair to the range of 40 to 140° C., wherein the aqueous composition comprises one or more cationic quaternary ammonium polymers having a cationic charge density of 3.0 mEq/g or more and one or more nonionic surfactants.

Abstract: The present invention relates to a composition for dyeing keratin fibres, comprising: a) at least one copolymer derived from the polymerization of at least one crotonic acid monomer or crotonic acid derivative and of at least one vinyl ester monomer, b) at least one fatty amine, and c) at least one pigment.

Abstract: A hair cosmetic composition including component (A), which is an aqueous gelling agent represented by general formula (1) described in the specification, and a component (B), which includes either one of or both of a cationic surfactant and a cationic polymer, wherein the component (A) presents a viscosity of an aqueous solution containing 1 mass % of at 25° C. of 1,000 to 5,000 mPa·s and a clouding point of the aqueous solution containing 1 mass % of component (A) of 60° C. to 80° C., and has a weight average molecular weight of 10,000 to 30,000; a method for producing the aqueous gelling agent and a method for producing the hair cosmetic composition are provided.

Abstract: The instant disclosure relates to hair treatment compositions that include a unique combination of components that function to impart desirable cosmetic properties to the hair. The hair treatment compositions typically include a first phase containing a non-polymeric mono, di, or tricarboxylic acid, and/or a salt thereof, an amine, a cationic polymer, an alkoxysilane, polyols, and water; and a second phase containing a film-forming aminosilicone polymer formed by the reaction between a glycidoxypropyl-terminated dimethyl siloxane polymer, PEG-13 diglycidyl ether, diethylaminopropylamine, and aminopropyltriisopropoxysilane, and at least one silicone oil.

Abstract: An oral hygiene composition which relates to oral hygiene compositions. More particularly, the present disclosure relates to a toothpaste which combines stannous fluoride and tea tree oil (Melaleuca). The composition prevents tooth decay and new cavity formation on enamel and dentin, reducing dentinal hypersensitivity when used regularly. The present disclosure helps prevent gum disease (Gingivitis) bad breath and improves oral hygiene and overall health.

Abstract: The present invention provides a hair growth composition, a method of making the composition, and a method of treating a subject to enhance hair growth. The hair growth composition includes about 15 to about 38% by volume Fenugreek seed-infused botanical oil; about 13 to about 23.5% by volume castor oil; and an amount of at least one additional botanical component. The method of making a hair growth composition includes steeping fenugreek seeds in a botanical oil for at least about 9 hours to produce an infused botanical oil; removing the steeped fenugreek seeds from the infused botanical oil; and mixing castor oil, rose oil, peppermint oil, and aloe vera oil with the infused botanical oil. The method of treating a subject includes applying about two drops of a hair growth composition to a scalp every two days and massaging the hair growth composition into the scalp.

Abstract: Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for improving sallow-looking skin by enhancing bilirubin breakdown in skin. The methods and compositions herein utilize a water lily extract that demonstrates a surprising ability to reduce bilirubin levels. The method involves applying a skin care composition containing an effective amount of water lily extract to a target portion of skin where a reduction in bilirubin level is desired.

Abstract: The subject matter of the invention is a cosmetic active ingredient comprising at least one hydrolysate of Nymphaea alba flowers, as well as cosmetic compositions including said active ingredient and its use in cosmetics. In particular, the invention relates to the use of an extract of Nymphaea alba flowers for improving skin complexion.

Abstract: The present disclosure is directed to a method for producing an olive branch extract having a high oleuropein content. The method includes crushing at least a portion of dried olive branch and extracting olive branch extract from the crushed olive branch with an extraction solvent. The olive variety is at least one selected from Lucca, Mission, and Nevadillo Blanco. The added branch amount of olive branch to the extraction solvent is 10% by weight or more, the extraction solvent is 30% to 50% 1,3-butylene glycol, and the extraction is performed at a temperature in a range of 70° C. to 80° C.

Abstract: Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts. Production of collagen, elastin and hyaluronic acid are increased after application of the compositions.

Abstract: A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.

Abstract: The present disclosure provides programmable osmotic-controlled oral compositions providing delayed release of a therapeutically acceptable amount of a drug. The programmable osmotic-controlled compositions of the disclosure provide a lag time that is independent of the presence or absence of food, type of food, pH, gastric emptying, gastric motility, and volume and viscosity of gastric fluid. The compositions of the disclosure can be programmed to provide a desired and precise lag time, and release drug, after the lag time, at a rhythm, e.g., that matches the human circadian rhythm of a condition's symptoms and/or of the individual being treated in the application of the therapy to optimize therapeutic outcome and minimize side effects.