Patents Issued in February 9, 2021
  • Patent number: 10912914
    Abstract: A filler adaptor assembly includes a base, an outer ring, and iris members. The base has a central opening. The outer ring is disposed circumferentially about the base and is rotatable relative to the base. The iris members are pivotably coupled to the base. The iris members cooperate to define an iris opening and are movable to vary the iris opening. The iris members are coupled to the outer ring, and move between an open position and a closed position when the outer ring is rotated relative to the base.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: February 9, 2021
    Assignee: GE PRECISION HEALTHCARE LLC
    Inventor: Joe M. Bexson
  • Patent number: 10912915
    Abstract: In an exemplary embodiment, a body-supporting structure for multisensory stimulation may be provided. The body-supporting structure for multisensory stimulation may include a number of biometric measurement devices for detecting a user's state and a number of speakers or transducers connected to resonators on the body-supporting structure and arranged to transfer a stimulus in accordance with the state detected. A computing device may be connected to the biometric measurement devices and to a virtual reality display. A number of input devices may also be connected to the computing device and to a number of amplifiers configured to transfer a signal to the number of speakers and transducers.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: February 9, 2021
    Inventor: Itai Argaman
  • Patent number: 10912916
    Abstract: Systems, methods, and computer-readable media are disclosed for automatic display modifications to avoid motion sickness. Example methods may include determining a first acceleration value of a device in a first direction, determining a first acceleration vector using the first acceleration value, and determining a baseline location of a focal point of a display of the device. Some embodiments may include determining a first adjusted location of the focal point of the display based at least in part on the first acceleration vector, and causing presentation of a graphical indicator of the first adjusted location of the focal point at the display, where the graphical indication is positioned at a second direction relative to the baseline location, and the second direction is opposite the first direction.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: February 9, 2021
    Assignee: Ford Global Technologies, LLC
    Inventors: Alan Dry, Jimmy Moua, Johnathan Andrew Line, Marcos Silva Kondrad, Kevin Preuss
  • Patent number: 10912917
    Abstract: A catheter assembly (11) includes an elongate member (14) having a proximal end (18) and a distal end (19). The distal end (19) has at least one drainage opening (15). A fluid containing member (20) is arranged on the elongate member (14). A container (12) contains the elongate member (14) and the fluid containing member (20). A method of using the catheter assembly (11) includes inserting a catheter (14) into a user's body and draining a fluid from the user's body.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: February 9, 2021
    Assignee: C. R. Bard, Inc.
    Inventor: Richard Terry
  • Patent number: 10912918
    Abstract: A rigid package or container for a sterile pre-lubricated, ready to use female-length catheter with enhanced gel receptacles and simple constructions. A main body of the rigid container has a hollow interior which may receive a gel receptacle defining an inner cavity filled with a lubricating gel. The gel receptacle partly inserts into the main body and a tube of the catheter inserts through the gel receptacle into the main body with a proximal outlet projecting out of the gel receptacle so as to be graspable. Alternatively, the gel may be provided within the hollow interior of the main body. A rigid and closed cap seals to either the main body or the gel receptacle and closes the hollow interior of the main body.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: February 9, 2021
    Assignee: Cure Medical LLC
    Inventor: Timothy A. Palmer
  • Patent number: 10912919
    Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member having longitudinally extending channels that facilitate the sheath's temporary expansion. The channels are positioned in such a way that, upon expansion, they enable the movement of protruding contact surfaces toward the inner and outer surfaces of the annular member, reducing friction between the surface and the passing device. Some embodiments of the expandable sheath include an elastic outer layer that pushes the protruding contact surfaces back towards their original positions after the passage of the device.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: February 9, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Erik Bulman, Pu Zhou
  • Patent number: 10912920
    Abstract: Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 9, 2021
    Assignees: University of Maryland, Baltimore, University of Maryland, Baltimore County
    Inventors: Zhongjun Wu, Bartley P. Griffith, Jun Ding
  • Patent number: 10912921
    Abstract: A multilayer body, a multilayer hollow body, and a catheter with a multilayer hollow body each have improved torque transmissibility to one end when the other end is rotated rightward or leftward. The multilayer hollow body includes a single-strand hollow body that is formed by winding one element wire, an inner multi-strand hollow body that is disposed adjacently to an inner periphery of the single-strand hollow body and is formed by winding a plurality of element wires in an opposite direction from the single-strand hollow body, and an outer multi-strand hollow body that is disposed adjacently to an outer periphery of the single-strand hollow body 7 and is formed by winding a plurality of element wires in an opposite direction from the single-strand hollow body.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: February 9, 2021
    Assignee: ASAHI INTECC CO., LTD.
    Inventor: Atsuhiro Hanaoka
  • Patent number: 10912922
    Abstract: A modular medical device catheter system comprises a parent module and an adapter module. The adapter module is configured to engage an inner lumen of a distal end of the parent module to couple the adapter module with the parent module.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: February 9, 2021
    Assignee: COVELLUS LLC
    Inventor: Bradley Beach
  • Patent number: 10912923
    Abstract: A catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism. The steering mechanism includes at least one flat wire and a corresponding lumen through which the flat wire may travel. The steering mechanism may also include at least one pull ring to which the flat wires are attached. A layer of heat shrink material may encompass the outer layer. A braided wire assembly may also be provided in the outer layer, and may be formed by braiding a plurality of flat wires into a wire mesh. The overall cross-section of the catheter assembly is preferably substantially circular. A catheter shaft may include a plurality of segments of differing hardness characteristics. The outer layer typically comprises a melt processing polymer such that the catheter assembly may be laminated using heat.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: February 9, 2021
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventors: Wayne Heideman, Allan M. Fuentes, Richard E. Stehr, Sarah Cumming, Mark Dustrude
  • Patent number: 10912924
    Abstract: A robotic catheter system may include a flexible catheter having a proximal end, a distal end, and an articulating portion at the distal end. It may further include a sensor coupled with the flexible catheter at or near the distal end, a visual display for displaying an image of at least part of the flexible catheter, a processor for generating a virtual indicator displayed on the image of the flexible catheter, where the virtual indicator indicates a direction of articulation and/or an amount of articulation of the articulating portion of the catheter, and a controller coupled with the proximal end of the flexible catheter to receive a user input and articulate the articulating portion of the catheter in response to the user input.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: February 9, 2021
    Assignee: Auris Health, Inc.
    Inventors: June Park, Ray D'Ambrosio, Sean P. Walker
  • Patent number: 10912925
    Abstract: A deflectable catheter shaft with compression resistance coils configured to create different curve shapes when the catheter is steered or deflected in different directions. One or more compression resistance coils may include an elongated-pitch section. The compression resistance coils may be pull wire compression coils or body compression coils.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: February 9, 2021
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Alexander Carson Houck
  • Patent number: 10912926
    Abstract: A catheterization system for treatment of patients can include a peripherally inserted central catheter comprising a catheter tube joined to an extension leg with a junction and a securement device that fits around a portion of the junction to inhibit movement. The catheter tube can include a taper proximate the junction, the taper transitioning the catheter tube from a larger outer diameter and a larger wall thickness to a smaller outer diameter and a smaller wall thickness. The taper and thicker wall thickness near the junction can help prevent damage to the catheter tube near the junction when bent (e.g., to secure a proximal region of the catheter to a patient's arm). The securement device can configured to fit around an outer diameter of the junction to inhibit movement of the junction when the junction is held in the securement device.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: February 9, 2021
    Assignee: C. R. Bard, Inc.
    Inventors: Lisa I. Bailey, Chad A. Hadley, Caleb Campbell, Paul H. Shin, Richard B. Lewis
  • Patent number: 10912927
    Abstract: Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: February 9, 2021
    Assignee: INTERRAD Medical, Inc.
    Inventors: Michael S. Rosenberg, Mark R. Christianson
  • Patent number: 10912928
    Abstract: Needle assemblies are generally discussed herein with particular discussions extended to needle assemblies having a tip protector with a plurality of wall surfaces for preventing contact with the needle tip from a side. Aspects of the tip protectors discussed herein include a first protector body having an arm for blocking a needle tip surrounded by a second protector body having a plurality of wall surfaces.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: February 9, 2021
    Assignee: B. Braun Melsungen AG
    Inventor: Kevin Woehr
  • Patent number: 10912929
    Abstract: A tubular body that includes a plurality of first wires distributed in an annular portion of the tubular body, and a plurality of deformed second wires alternately disposed between each of the plurality of first wires, the plurality of first wires and the plurality of deformed second wires being in an alternately twisted arrangement in a longitudinal direction of the tubular body, where each of the plurality of first wires has a substantially circular shape in a cross section view, and each of the plurality of deformed second wires has a non-circular shape in the cross section view, has an arcuate side portion that receive a part of a side surface of an adjacent wire of the plurality of first wires, and has an annular sector shape protruding in a radial direction in the cross section view of the tubular body.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: February 9, 2021
    Assignee: ASAHI INTECC CO., LTD.
    Inventors: Hiroyuki Nishihara, Aya Takechi
  • Patent number: 10912930
    Abstract: A catheter insertion device includes a housing, a needle, a guide wire, and a catheter disposed coaxially over the needle. The needle has a proximal end in the housing and a distal end extending from a distal end of the housing in an insertion position. The guide wire has a distal portion disposed in a lumen of the needle in a withdrawn position. The guide wire may include a safety tip having a non-coiled configuration in the withdrawn position and a coiled configuration in an advanced position. The catheter insertion device may include a sliding member attached to the guide wire, wherein movement of the sliding member translates the guide wire from the withdrawn position to the advanced position.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: February 9, 2021
    Assignee: Vascular Pathways, Inc.
    Inventors: Jessica A. Warring, Amir Belson, Winfield S. Fisher
  • Patent number: 10912931
    Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 9, 2021
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Patent number: 10912932
    Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 9, 2021
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Patent number: 10912933
    Abstract: Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 9, 2021
    Assignee: The Regents of the University of California
    Inventors: Pamela Munster, Jim Kiriakis, Hani Sbitany, Scott Thomas
  • Patent number: 10912934
    Abstract: The present disclosure generally relates to methods and compositions for treating skin. In some embodiments, the method uses an exfoliation tool. In some embodiments, the method uses an exfoliation tool together with selected skin care agents or compositions.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: February 9, 2021
    Assignee: RODAN & FIELDS, LLC
    Inventors: Kathryn P. Rodan, Kathy A. Fields
  • Patent number: 10912935
    Abstract: An access port for providing subcutaneous access to a patient is disclosed. In one embodiment, the port includes an internal body defining a fluid cavity that is accessible via a septum. A compliant outer cover including silicone is disposed about at least a portion of the body. A flange is included with the port body and is covered by the outer cover. The flange radially extends about a perimeter of the port body proximate the septum so as to impede penetration of a needle substantially into the outer cover in instances where the needle misses the septum. The flange can further include both an anchoring feature for securing the outer cover to the port body and an identification feature observable via x-ray imaging technology for conveying information indicative of at least one attribute of the access port. The outer cover provides a suitable surface for application of an antimicrobial/antithrombotic coating.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: February 9, 2021
    Assignee: Bard Peripheral Vascular, Inc.
    Inventors: Martha R. Wiley, Jodie L. Noyce, David M. Cise, William R. Barron, Kelly J. Christian, Amir Orome
  • Patent number: 10912936
    Abstract: A tube-docking holding device includes a first connector bracket and a second connector bracket. The first connector bracket includes two shells. When the two shells are closed, a first accommodation space is surrounded for fixing a portion of a first connector assembly of a catheter. The second connector bracket includes a base body and a cover body. The base body includes a first inner shell and a first outer shell. The cover body includes a second inner shell and a second outer shell. When the cover body and the base body are closed, the first inner shell and the second inner shell surround and define a second accommodation space for fixing a portion of a second connector assembly of a dialysate tube. An interconnected guiding space is formed between the first inner shell and the first outer shell and between the second inner shell and the second outer shell.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: February 9, 2021
    Assignees: National Formosa University, National Taiwan University Hospital Yun-Lin Branch
    Inventors: Sung-An Lin, I-En Lin, Feng-Jung Yang, Hao-Ting Chiang
  • Patent number: 10912937
    Abstract: Disclosed are devices, electrodes, systems, methods, and other implementations, including a device that includes an electrode comprising an elongated body, a plurality of electrode contacts disposed on a first side of the elongated body, and a cannulation channel defined along a longitudinal axis of the electrode. The device further includes a guiding mechanism received within the cannulation channel, the guiding mechanism configured to guide the electrode for placement at a target area inside a body of a patient. In some embodiments, the cannulation channel is configured to receive irrigation fluids dispensed through a perforated end located near a leading tip of the elongated body.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: February 9, 2021
    Assignee: Tufts Medical Center, Inc.
    Inventor: James Kryzanski
  • Patent number: 10912938
    Abstract: The disclosure relates to a multipolar, detection/stimulation endovascular lead intended to be implanted in the coronary venous network. The lead comprises a lead body with in proximal portion a connector to a cardiac pacemaker/defibrillator generator, and in a distal portion a first branch and a second branch extending beyond a bifurcation. The distal ends of the branches are free ends carrying an array of electrodes connected to the connector. Each of the branches comprises at its free end an outlet in the distal direction, able to receive an implantation guide wire inserted therein and to guide the implantation guide wire in an axial direction parallel to the main axis of the lead body.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: February 9, 2021
    Assignee: Sorin CRM SAS
    Inventor: Jean-François Ollivier
  • Patent number: 10912939
    Abstract: An electroporation device for injecting a product into a ciliary muscle of an eye, said device comprising: a support having a support contact surface extending along a virtual sphere having a radius between 10 and 15 mm, so as to match the outside surface of the eye, a first electrode comprising an invasive electrode needle, a second electrode having an electrically conductive electrode contact surface, optionally an injection needle, wherein the support comprises an insertion guide configured to guide a sliding of said electrode needle and/or injection needle along a respective insertion axis, so that the angle between said insertion axis and a plane tangential to the virtual sphere at the insertion point is less than 40°, the insertion point being the point where said insertion axis crosses said virtual sphere.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: February 9, 2021
    Assignee: EYEVENSYS
    Inventors: Luc Lebreton, Elodie Touchard, Romain Benard, Karine Bigot, Cécile Madaras, Francine Behar-Cohen
  • Patent number: 10912940
    Abstract: An exemplary connection joint includes a wire constructed from a first conductive material having a first melting point and a pad constructed from a second conductive material different from the first conductive material and having a second melting point lower than the first melting point. The connection joint further includes a groove within the pad that partially surrounds the wire and a fixative covering the wire and the pad so as to fix the wire in place within the groove. The groove is formed by a displacement of the second conductive material that occurs when the wire is in contact with the pad at a contact area of the pad that is heated to a temperature between the first and second melting points so as to reflow the second conductive material from which the pad is constructed without reflowing the first conductive material from which the wire is constructed.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: February 9, 2021
    Assignee: Advanced Bionics AG
    Inventors: Jeryle L. Walter, Enrique Gandaria
  • Patent number: 10912941
    Abstract: Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals. The neuromodulation is well-suited for deep brain stimulation (DBS) applications.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: February 9, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Shalom Michaeli, John T. Vaughan, Silvia Mangia, Lauri Lehto, Matthew Johnson, Julia Slopsema, Olli Gröhn, Gregory F. Molnar
  • Patent number: 10912942
    Abstract: An implantable pulse generator (IPG) is disclosed having an improved ability to steer anodic and cathodic currents between the IPG's electrodes. Each electrode node has at least one PDAC/NDAC pair to source/sink or sink/source a stimulation current to an associated electrode node. Each PDAC and NDAC receives a current with a magnitude indicative of a total anodic and cathodic current, and data indicative of a percentage of that total that each PDAC and NDAC will produce in the patient's tissue at any given time, which activates a number of branches in each PDAC or NDAC. Each PDAC and NDAC may also receive one or more resolution control signals specifying an increment by which the stimulation current may be adjusted at each electrode. The current received by each PDAC and NDAC is generated by a master DAC, and is preferably distributed to the PDACs and NDACs by distribution circuitry.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: February 9, 2021
    Assignee: Boston Scientific Neuromoduiation Corporation
    Inventors: Pujitha Weerakoon, David M. Wagenbach, Philip L. Weiss, Goran N. Marnfeldt
  • Patent number: 10912943
    Abstract: Systems and methods for communicating between medical devices. In one example, an implantable medical device comprising may comprise one or more electrodes and a controller coupled to the electrodes. The controller may be configured to receive a first communication pulse at a first communication pulse time and a second communication pulse at a second communication pulse time via the one or more electrodes. The controller may further be configured to identify one of three or more symbols based at least in part on the time difference between the first communication pulse time and the second communication pulse time.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: February 9, 2021
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Keith R. Maile, Michael J. Kane, Paul Huelskamp, Lance Eric Juffer, Jeffrey E. Stahmann
  • Patent number: 10912944
    Abstract: Techniques for determining the location of a physiological midline are disclosed. A first technique evaluates the response to stimulation of spinal electrodes at peripheral electrodes on different sides of the body. In this technique, a spinal electrode's position relative to a physiological midline is determined based on a relationship between responses to its stimulation observed on different sides of the body. A second technique evaluates the response of spinal electrodes to stimulation of peripheral electrodes on different sides of the body. In this technique, a spinal electrode's position relative to a physiological midline is determined based on the different responses that it observes to stimulation on different sides of the body.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: February 9, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Raul Serrano Carmona, Bradley Hershey
  • Patent number: 10912945
    Abstract: A filter feedthrough for an AIMD includes an electrically conductive ferrule. An insulator hermetically seals a ferrule opening with either a first gold braze, a ceramic seal, a glass seal or a glass-ceramic seal. At least one conductive pathway is hermetically sealed to and disposed through the insulator body in non-conductive relationship with the ferrule. A feedthrough capacitor includes at least one active and ground electrode plate disposed within a capacitor dielectric and electrically connected to a capacitor active metallization and a capacitor ground metallization, respectively. At least a first edge of the feedthrough capacitor extends beyond a first outermost edge of the ferrule. At least a second edge of the feedthrough capacitor does not extend beyond a second outermost edge of the ferrule, or said differently, the second edge is either aligned with or setback from the second outermost edge of the ferrule.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: February 9, 2021
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Christine A. Frysz, Jason Woods
  • Patent number: 10912946
    Abstract: A device for generating alternating magnetic fields for inducing eddy currents in an organism in order to treat tinnitus comprising a head part, a current source, a controller, and one or more coils. At least one coil has at least two layers with a different winding, whereby alternating magnetic fields can be generated more effectively for inducing eddy currents in an organism in order to treat tinnitus.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: February 9, 2021
    Assignee: CLEANHEARING INC.
    Inventor: Gerald Neuwirth
  • Patent number: 10912947
    Abstract: The present disclosure describes systems, apparatus, and methods for application of dynamic magnetic field (DMF) treatment to direct movement, and specifically rotation, of magnetic particles associated with a target structure, so that mechanical force is applied to the target structure. In certain embodiments, the present disclosure demonstrates application of DMF treatment to direct rotation about the axis in individual magnetic particles (e.g., superparamagnetic nanoparticles), effecting permeabilization and/or other disruption of membranes (e.g., cell membranes and/or intracellular membranes). In certain embodiments, the present disclosure describes use of an alternating current superconductor (ACSC) to greatly enhance the magnetic field amplitude so that the field can penetrate deeper into a body with sufficient amplitude to control movement of the nanoparticles within a working volume.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: February 9, 2021
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Moritz F. Kircher, Erik Renström, Martin Koch, Ernst Stetter, Thomas Reis
  • Patent number: 10912948
    Abstract: The present invention provides a composite intelligent biological phototherapy device including a base structure, a plurality of white light fluorescent tubes arranged side by side on the base structure, a plurality of LEDs disposed between the white light fluorescent tubes, a housing having an opening and configured to accommodate the base structure and the white light fluorescent tubes and the LEDs thereon, a light-transmittable plate disposed on the housing corresponding to the opening, and an control module configured to respectively control the white light fluorescent tubes and the LEDs. The base structure includes a plurality of sections, and each of the sections has a first surface facing the light-transmittable plate. The white light fluorescent tubes and the LEDs are provided on the first surfaces, and the sections are bent relative to each other so an angle between the first surfaces of adjacent sections is less than 180 degrees.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: February 9, 2021
    Assignee: NATIONAL APPLIED RESEARCH LABORATORIES
    Inventors: Yi-Cheng Lin, Hsin-Yi Tsai, Min-Wei Hung, Kuo-Cheng Huang, Hsin-Su Yu, Chiou-Lian Lai, Chung-Yao Hsu, Chao-Hung Cheng, Li-Wei Kuo, Hung-Che Chiang, Chih-Yi Yang
  • Patent number: 10912949
    Abstract: Multi-criteria optimization of radiation therapy tools for receiving a plurality of criteria including one or more sets of competing objectives. The competing objective can include delivery time criteria, fractionation criteria or similar time-based criteria. One or more radiation therapy plans can be determined based on a multi-criteria optimization of the plurality of criteria for the radiation therapy treatment. The one or more optimized radiation therapy plans can be output for consideration by one or more members of a radiation oncology team.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: February 9, 2021
    Assignees: Varian Medical Systems, Inc., Varian Medical Systems International AG
    Inventors: Timo Koponen, Perttu Niemela, Markus Bach, Jan Timmer, Christel Smith
  • Patent number: 10912950
    Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: February 9, 2021
    Assignee: RefleXion Medical, Inc.
    Inventors: Debashish Pal, Ayan Mitra, Christopher Eric Brown, Peter Demetri Olcott, Yevgen Voronenko, Rostem Bassalow
  • Patent number: 10912951
    Abstract: A radiation-treatment plan that comprises a plurality of dose-delivery fractions can be optimized by using fraction dose objectives and at least one other, different dose objective. This use of fraction dose objectives can comprise accumulating doses delivered in previous dose-delivery fractions. The other, different dose objective can comprise a remaining total dose objective, a predictive dose objective, or some other dose objective of choice. An existing radiation-treatment plan having a corresponding resultant quality and that is defined, at least in part, by at least one delivery parameter can be re-optimized by specifying at least one constraint as regards that delivery parameter as a function, at least in part, of that resultant quality and then applying that constraint when re-optimizing the existing radiation-treatment plan.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: February 9, 2021
    Assignee: Varian Medical Systems International AG
    Inventors: Janne I. Nord, Jarkko Y. Peltola, Juha Kauppinen
  • Patent number: 10912952
    Abstract: A high-energy radiation treatment system can comprise a laser-driven accelerator system, a patient monitoring system, and a control system. The laser-driven accelerator system, such as a laser-driven plasma accelerator or a laser-driven dielectric microstructure accelerator, can be constructed to irradiate a patient disposed on a patient support. The patient monitoring system can be configured to detect and track a location or movement of a treatment volume within the patient. The control system can be configured to control the laser-driven accelerator system responsively to the location or movement of the treatment volume. The system can also include a beam control system, which generates a magnetic field that can affect the radiation beam and/or secondary electrons produced by the irradiation beam. In some embodiments, the beam control system and the patient monitoring system can comprise a magnetic resonance imaging system.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: February 9, 2021
    Assignee: VARIAN MEDICAL SYSTEMS, INC.
    Inventor: James E. Clayton
  • Patent number: 10912953
    Abstract: Embodiments of the present invention disclose methods and systems for producing an adaptive pencil beam having an adjustable lateral beam size and Bragg-peak width. According to one disclosed embodiment, an apparatus for producing an adaptive pencil beam is disclosed. The apparatus includes a set of momentum band expanders configured to widen a momentum spread of a pencil beam, where a momentum band expander is selected from the set of momentum band expanders to receive the pencil beam, and a slit at dispersive focus of two dipole magnets to adjust a width of a Bragg-peak of the pencil beam. According to another disclosed embodiment, a method for producing an adaptive pencil beam with an adjustable lateral beam is disclosed. The method includes selecting a scatter foil, or setting of a defocusing/focusing magnet, and adjusting a lateral size of the pencil beam.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: February 9, 2021
    Assignee: Varian Medical Systems Particle Therapy GMBH
    Inventor: Joerg Wulff
  • Patent number: 10912954
    Abstract: A patient shuttle system, an irradiation system for particle therapy and an operation method thereof are provided. One embodiment of the present invention provides a patient shuttle system including a patient table on which a patient is placed, a drive device that causes the patient table to move parallel and/or rotate, and a drive control device that controls parallel movement and/or rotation of the patient table by the drive device, in accordance with a parallel movement amount and/or a rotation amount of the patient table that are received from a patient positioning system provided in a treatment room for particle therapy.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: February 9, 2021
    Assignee: B DOT MEDICAL INC.
    Inventors: Yousuke Hara, Takuji Furukawa, Eri Takeshita, Kota Mizushima
  • Patent number: 10912955
    Abstract: A process is provided for inhibiting symptoms of celiac disease, Clostridium difficile associated diseases such as Clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, food allergy or food intolerance in a subject that includes the oral administration to the subject suffering from food allergy or food intolerance an IgM. When administered in a, therapeutic quantity based on the subject characteristics and the type of IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgM are effective when administered orally.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: February 9, 2021
    Inventor: Michael R. Simon
  • Patent number: 10912956
    Abstract: The present invention relates generally to methods and compositions comprising Hylocereus undatus fruit extract and Aloe barbadensis leaf extract, useful as antioxidants and/or inhibiting TNF-? expression.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: February 9, 2021
    Assignee: Mary Kay Inc.
    Inventors: Barbara Durkee, Daniel Ramirez, Maria Milagros Sanchez, Michael Frushour, Geetha Kalahasti, Lisha Vanpelt
  • Patent number: 10912957
    Abstract: A multifunctional rescue tool providing a plurality of tool components including an angled blade to disengage a lock shielded by a blocker plate and wherein the angled blade has a base portion and an integral elongate distal portion forming an angle along a contiguous planar surface that is preferably substantially perpendicular and is pivotally coupled to a handle having a corresponding slot configured for receiving the angled blade wherein the elongate distal portion is angled outwardly from the base portion of the angled blade in a preferably perpendicular orientation when the base portion and handle are locked in substantial alignment in an open position, and the angled blade is alternatively engageable to form additional angles to facilitate construction of raker shores while also including various tool components including a window breaker, seat belt cutter, gas shut off, oxygen tank, hexagonal wrenches, as well as, a lanyard, shove knife, and cutting knife in a compact configuration capable of convenie
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: February 9, 2021
    Inventor: Jason Allen
  • Patent number: 10912958
    Abstract: An enhanced claw in a tactical breaching system for breaching a door system having a door and a door frame, the tactical breaching system having a hydraulic cylinder configured to drive a drive piston, the enhanced claw comprising: a stationary static tooth pair mechanically fixed to the hydraulic cylinder, the static tooth pair having top and bottom static tooth surfaces; a dynamic tooth axially attached to the drive piston, the dynamic tooth having top and bottom dynamic surfaces, the dynamic tooth configured to be driven forward and away from the static tooth pair, the static tooth pair and the dynamic tooth initially aligned in a closed configuration, the enhanced claw having a plurality of parameters shared by the static tooth pair and the dynamic tooth, including; a sharply-tapered and curved profile; a relative tooth length parameter; a robustness of the claw to resist torsion; and opposing sets of grooved teeth on the top surface of the static tooth pair and on the bottom surface of the dynamic tooth,
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: February 9, 2021
    Assignee: San Hitec LTD.
    Inventors: Ran Nakash, Itam Lachiani
  • Patent number: 10912959
    Abstract: A respirator oxygen mask having a filter, a mask body, an outer edge is described herein. Disposed in the mask body of the respirator oxygen mask is a mask opening and a straw opening, with the mask opening disposed above the straw opening. Additionally, a sliding door is adapted to cover the mask opening. The straw opening having a mask straw attachment adapted to receive a straw and a straw opening cover removably attached to the mask straw attachment. The respirator oxygen mask also having a face mask reduction attachment adapted to fasten to the outer edge. Furthermore, the mask body having a front surface with a hose attachment ring disposed over the filter and adapted to receive a tube and a rear surface with a filter holder and a filter cover to secure the filter in place.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: February 9, 2021
    Inventor: Edward Showalter
  • Patent number: 10912960
    Abstract: A housing having an inner chamber; one or more channels within the housing; one or more inlet ports for allowing air into the one or more channels; each inlet port having a filter to filter air allowed into the one or more channels; the one or more channels connected so that the same air can flow through all of the one or more channels; a pool of electrolyzed high acidity water in the inner chamber of the housing; and wherein contaminants in air flowing through the one or more channels are configured to fall into the pool of electrolyzed water. The apparatus may further include an ultraviolet light source; wherein the ultraviolet light source is directed at air flowing in the one or more channels to cause contaminants in the air to be killed. A mask may be configured to attach and detach from the one or more channels.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: February 9, 2021
    Inventor: Tom Bittar
  • Patent number: 10912961
    Abstract: Provided is a mask having a built-in adsorptive membrane, the mask including: a mask body having the built-in adsorptive membrane for adsorbing foreign substances contained in air; and a hanger band fixed to the mask body to be hung and fixed to the ear, wherein the adsorptive membrane comprises: a support member having a plurality of first pores; and a first adsorptive member that is stacked on the support member and has a plurality of second pores formed therein and that is made by accumulating ion exchange nanofibers for adsorbing ionic foreign substances in the foreign substances.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: February 9, 2021
    Assignee: AMOGREENTECH CO., LTD.
    Inventors: In Yong Seo, Ui Young Jeong
  • Patent number: 10912962
    Abstract: A portable anchoring apparatus that includes a first connecting arm having a connecting hole, a second connecting arm, a first anchoring arm and a second anchoring arm. The first connecting arm and the second connecting arm are connected in overlap and parallel one to the other by a ratchet mechanism that includes an opening ratchet button. The first connecting arm and the first anchoring arm are connected to each other by an axial connector that has an opening button. The second connecting arm and the second anchoring arm are connected to each other by an axial connector that has an opening button.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: February 9, 2021
    Assignee: HIGHNOVATE
    Inventors: Beeri Berl Katznelson, Idan Peretz, Eyal Mastboim
  • Patent number: 10912963
    Abstract: A system for explosively applying a fire-fighting foam is provided. The system includes a thermoelectric generator that is attached to a battery heat source. A temperature differential across the thermoelectric generator generates an electrical current having a temperature-dependent voltage. A detonator circuit is electrically connected to the thermoelectric generator. The detonator circuit measures the voltage of the electrical current. An explosive foam applicator is communicatively connected to the detonator circuit and includes a trigger mechanism that detonates a propelling charge in response to receiving a signal from the detonator circuit when the detonator circuit determines that the electrical current corresponds to temperature that is greater than or equal to a threshold temperature. The explosive foam applicator is oriented such that detonating the propelling the charge causes the explosive foam applicator to apply a foam to the battery heat source.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: February 9, 2021
    Assignee: International Business Machines Corporation
    Inventors: Guoda Lian, James A. O'Connor, Madhana Sunder, Conor R. Thomas