Patents Issued in February 9, 2021
  • Patent number: 10913672
    Abstract: In some embodiments, the present invention provides a recombinant protein comprising an affinity tag configured to attach the recombinant protein to a silicate surface, fused to a hydrogen sulfide scavenging enzyme.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 9, 2021
    Assignee: BAKER HUGHES, A GE COMPANY, LLC
    Inventors: Charles D. Armstrong, Frances H. Debenedictis
  • Patent number: 10913673
    Abstract: In some embodiments, the present invention provides a recombinant protein comprising an affinity tag configured to attach the recombinant protein to a silicate surface, fused to a hydrogen sulfide scavenging enzyme.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 9, 2021
    Assignee: BAKER HUGHES, A GE COMPANY, LLC
    Inventors: Charles D. Armstrong, Frances H. Debenedictis
  • Patent number: 10913674
    Abstract: An apparatus (12) for treating water, in particular for removing surfactants from waste water, includes a vessel (14), defining an inlet (16) for receiving waste water containing air bubbles, and an outlet (20) for the exit of water, following treatment. Inside the vessel there is at least one tubular member (50) having a lower open end (52) into which the flow of waste water from the inlet may be directed in use. The tubular member (50) extends from the inlet towards a top of the vessel where an upper exit (54) from the tubular member is defined. In use, most un-aerated water entering the vessel through the inlet can exit the tubular member at the lower open end. Foam formed in the water by the air bubbles may travel up the tubular member to the upper exit, which is preferably located above the water level (60) in the vessel.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: February 9, 2021
    Assignee: NEXUS EWATER PTY LTD
    Inventors: Andrew James Hermann, Thomas Andrew Wood
  • Patent number: 10913675
    Abstract: Methods and systems are provided for industrial wastewater treatment that yields zero liquid discharge (ZLD). These include pre-treating provided industrial wastewater to remove heavy metals, ultra-filtering the pre-treated wastewater to remove suspended and colloidal solids, nano-filtering the ultra-filtered wastewater to yield treated water (with monovalent ions) and a concentrate, treating the concentrate to remove di- and tri-valent elements and other compounds from the concentrate, and to reduce a level of sulfates to a specified level which is above a solubility level of sulfates—to yield returned water, and sludge, mixing the returned water with the provided industrial wastewater before or at the first treatment stage and/or with the pre-treated wastewater before the ultrafiltration, and removing residual water from the sludge to yield removed solids with ZLD. Advantageously, disclosed processes and systems are efficient, cheaper and more sustainable than prior art systems.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: February 9, 2021
    Assignee: P2W Ltd.
    Inventors: Ronny Banker, Yael Zeevy Perez
  • Patent number: 10913676
    Abstract: The present disclosure relates to a thermoforming method, a thermoforming mold, and a thermoforming device.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: February 9, 2021
    Assignee: AAC Technologies Pte. Ltd.
    Inventors: Wei Su, Bo Xu, Xuefeng Liu, Zaizhang Ye
  • Patent number: 10913677
    Abstract: An object of the invention is to provide a multilayer glass which can be manufactured by a simple process. To solve the above problem, the multilayer glass according to the invention includes a first glass substrate, a second glass substrate that faces the first glass substrate at an interval of a predetermined space, and a sealing part that seals a periphery of an internal space defined by the first glass substrate and the second glass substrate. The sealing part is formed with a sealing material containing low melting point glass. The internal space is in a vacuum state. The first glass substrate includes an exhaust port that is provided to be included in a projection part of the sealing part when being projected in a lamination direction of the first glass substrate and the second glass substrate. The exhaust port is blocked by the sealing material (see FIG. 3).
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: February 9, 2021
    Assignee: Hitachi, Ltd.
    Inventors: Tatsuya Miyake, Takashi Naitou
  • Patent number: 10913678
    Abstract: A vacuum mold shuttle system in a glass sheet forming system includes a vacuum mold mounted on a support frame. A shuttle frame including a pair of generally parallel elongate beams for receiving and supporting the mold support frame thereon. A vacuum source is mounted on the shuttle frame near the end of the beams opposite to the end supporting the mold, a conduit and coupling port for releasably connecting the mold to the vacuum source. At least one guide element is mounted on the support surface of one of the beams for receiving and fixing the position of the mold support frame relative to the shuttle frame to align and prevent movement of the mold support frame with respect to the shuttle frame in any direction as the mold support frame is supported thereon.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: February 9, 2021
    Assignee: GLASSTECH, INC.
    Inventors: David B. Nitschke, Kenneth J. Lane, Dean M. Nitschke
  • Patent number: 10913679
    Abstract: Disclosed are a miserite crystallized glass for an artificial tooth and a method for coloring same, the method enabling a production of a uniform shade without degrading the physical properties of a crystallized glass by means of simply adding a small amount of coloring additive powder when preparing the crystallized glass. A miserite crystallized glass for an artificial tooth according to the present invention is colored with any one of the shades in groups A, B, C and D of the Vita shade guide which is a tooth shade reference. The miserite crystallized glass has a miserite crystal phase as the main phase and comprises a hydroxyapatite crystal phase and a xonotlite crystal phase as additional phases.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: February 9, 2021
    Assignee: SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
    Inventors: Jae-Chul Bang, Young-Joo Song, Si-Won Sung, Seung-Bum Park
  • Patent number: 10913680
    Abstract: The purpose of the present invention is to provide a lead-free glass composition in which crystallization is suppressed and which has a low softening point. This lead-free glass composition is characterized by containing silver oxide, tellurium oxide and vanadium oxide, and further containing at least one compound selected from among yttrium oxide, lanthanum oxide, cerium oxide, erbium oxide, ytterbium oxide, aluminum oxide, gallium oxide, indium oxide, iron oxide, tungsten oxide and molybdenum oxide as an additional component, and in that the content values (mol %) of silver oxide, tellurium oxide and vanadium oxide satisfy the relationships Ag2O>TeO2?V2O5 and Ag5O?2V2O5 when calculated in terms of the oxides, and in that the content of TeO2 is 25-37 mol. %.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: February 9, 2021
    Assignee: HITACHI, LTD.
    Inventors: Takashi Naito, Takuya Aoyagi, Tatsuya Miyake, Takeshi Kondo, Hiroki Kaneko, Kazutaka Okamoto
  • Patent number: 10913681
    Abstract: The present invention discloses a glass-ceramic article and a glass-ceramic for an electric device cover plate, the glass-ceramic comprises, as a predominant crystalline phase, lithium silicate and the quartz crystalline phase, and has a composition expressed in weight percent including: SiO2: 65-85%, Al2O3: 1-15%, Li2O: 5-15%, ZrO2: 0.1-10%, P2O5: 0.1-10%, K2O: 0-10%, MgO: 0-10%, ZnO: 0-10%, and Na2O: 0-5%, wherein (SiO2+Al2O3+Li2O+ZrO2)/P2O5 is 40-90, the falling ball test height is 700 mm or more. By reasonable component design, the present invention achieves excellent mechanical properties of the glass-ceramic and the glass-ceramic article of the present invention and obtains the glass-ceramic or the glass-ceramic article suitable for electronic devices at a lower cost.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: February 9, 2021
    Assignee: CDGM GLASS CO., LTD.
    Inventor: Baoping Yuan
  • Patent number: 10913682
    Abstract: A material includes a transparent substrate coated with a stack of thin layers including at least one functional coating including at least one silver-based metal functional layer, and at least one niobium-based metal or nitride functional layer.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: February 9, 2021
    Assignee: SAINT-GOBAIN GLASS FRANCE
    Inventors: Laura Singh, Rémy Dodet
  • Patent number: 10913683
    Abstract: Provide is a cement ink for a cement ink for 3D printing (which also includes additive manufacturing) of 3D cement structures and materials. The cement ink includes an American Petroleum Institute (API) Class G cement, a nano-clay, a superplasticizer, a hydroxyethyl cellulose, and a defoamer. The nano-clay may be hydrophilic bentonite. The superplasticizer may be a polycarboxylate ether. The defoamer may be 2-ethyl-1-hexanol. Processes for forming the cement ink and printing 3D cement structures using the cement ink are also provided.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: February 9, 2021
    Assignees: Saudi Arabian Oil Company, William Marsh Rice University
    Inventors: Muhammad M Rahman, Seyed Mohammad Sajadi, Ashok Kumar, Peter J Boul, Carl Thaemlitz, Pulickel M Ajayan
  • Patent number: 10913684
    Abstract: A bonding element, a bonding element matrix and composite materials with a wide range of attractive properties that may be optimized, including, but not limited to, mechanical properties, thermal properties, magnetic properties, optical properties and nuclear properties, as a result of a first layer and second layer structure or core, first layer, and second layer structure of the bonding elements, as well as methods for making the bonding elements and the corresponding ceramic and/or composite materials.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: February 9, 2021
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Surojit Gupta, Vahit Atakan, Qinghua Li
  • Patent number: 10913685
    Abstract: A multifunctional comprehensive mineral supplement containing one or more molecular clusters, wherein each of the one or more molecular clusters has a metal-containing core and one or more ligands attached to the metal-containing core, wherein at least a portion of the metal-containing core and/or the one or more ligands is derived from a mineral component, wherein the mineral component is obtained from at least one mineral source, and wherein the at least one mineral source includes at least one selected from the group consisting of bauxite residue, ultrabasic rock, and a combination thereof.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: February 9, 2021
    Assignee: Dimtov Corp.
    Inventors: Stepan Minasov, Sharon Gililov
  • Patent number: 10913686
    Abstract: A composite ceramic powder of the present invention includes: a LAS-based ceramic powder having precipitated therein ?-eucryptite or a ?-quartz solid solution as a main crystal; and TiO2 powder and/or ZrO2 powder.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: February 9, 2021
    Assignee: NIPPON ELECTRIC GLASS CO., LTD.
    Inventors: Masayuki Hirose, Yoshikatsu Nishikawa, Takuji Oka
  • Patent number: 10913687
    Abstract: A composite material part includes a fiber preform forming fiber reinforcement including a stack of at least two fiber plies, each of the fiber plies being made of an interlock weave three-dimensional fabric and each of the fiber plies having a number of warp yarn layers or a number of weft yarn layers that is greater than or equal to three; and a matrix present in the pores of the fiber preform.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: February 9, 2021
    Assignee: SAFRAN AIRCRAFT ENGINES
    Inventor: Bruno Jacques Gérard Dambrine
  • Patent number: 10913688
    Abstract: A low density annular grout composition for filling voids. The composition may consist of cementitious fly ash, water, set retarder and cellular foam. The composition may have a compressive strength of between 100 and 600 psi at seven days and less than 1500 psi at 28 days. The composition may have a density between 20 and 75 pcf. Also disclosed is a method of filling a void with a low density annular grout composition. The method can include determining the time necessary to fill the void, adding water and set retarder to a cementitious fly ash to make a wet mixture, adding air to the wet mixture, and adding the composition to the void.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: February 9, 2021
    Assignee: EAGLE STRONG INVESTMENTS, LLC
    Inventors: Stanley R. Peters, George Clarence Geal, III
  • Patent number: 10913689
    Abstract: Fertilizer pellets may be formed by compressing or compacting a primary fertilizer powder mixed with micronized sulphur.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: February 9, 2021
    Inventors: Satish Iyer, Eric Pedersen, Richard Knoll, Babasola Ajiboye
  • Patent number: 10913690
    Abstract: A method of producing a fertiliser composition, the method comprising: (a) providing a composition comprising an amino compound; (b) contacting the composition provided in step (a) with a composition comprising carbon dioxide; and (c) adding a composition comprising cellulosic fibres to the mixture obtained in step (b).
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: February 9, 2021
    Assignee: CCm Technologies Limited
    Inventor: Peter Hammond
  • Patent number: 10913691
    Abstract: The Earthginuity Composting System is an organic waste composting system. It consists of three steps/components. The first step is using a free-standing cylindrical tube that goes in the kitchen. Organic waste goes into the tube. The second step is the Phase 1 Bin. It is a square-shaped plastic bin that sits on raw earth, and it's about thirty three gallons in volume. It has drainage holes at the bottom and two pegs protruding from the front to serve as “anchors” for dumping. The final component is the two Earth Grids. They are three by three feet, sandbox-like squares with NO bottoms and liquid-tight lids. The lack of a bottom to the Earthgrids allows for sitting on raw earth to attract ground bugs/bacteria. The lids have rain holes. You can open, close, and empty the Earth Grids with a Shepherd's Staff (hooked pole).
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: February 9, 2021
    Inventor: Alexander Joseph Stokes
  • Patent number: 10913692
    Abstract: A reduced toxicity pyrotechnic strobe composition and method includes creating a mixture of strontium nitrate, magnalium, sulfur, and no more than 10 parts by weight of a nitrocellulose binder. The strontium nitrate may comprise 27 percent of the mixture. The magnalium may comprise a 50:50 blend of magnesium and aluminum. The magnalium may comprise 18 percent of the mixture. The sulfur may comprise 55 percent of the mixture. The mixture may include a pulse rate of approximately one pulse per minute. The method may further include modifying the pulse rate of the mixture. The method may further include using a reduced particle size of the magnalium. The method may further include substituting no more than 12.5% of the strontium nitrate with potassium nitrate.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: February 9, 2021
    Assignee: America as Represented by the Secretary of the Army
    Inventors: Amee W LaBonte, Michael F Kauzlarich
  • Patent number: 10913693
    Abstract: The present application belongs to the field of energetic compounds, and particularly relates to the use of a perovskite-type compound ABX3 as an energetic material. As a finding of the present application, the structural characteristics of the perovskite type enables the type of compound to be highly stable, thus overcoming the unsafety of an explosive having poor stability in the prior art. Meanwhile, the structural characteristics of the compound, such as rich energetic ligands, as well as the alternately arranged oxidizing energetic anions and reducing organic cations in the space, endow the compound with excellent performance on instantaneously releasing energy at detonation. The resulting three-dimensional structure allows the compound to not only have an energetic material effect but also overcome shortcomings of some existing energetic materials.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: February 9, 2021
    Assignee: XI'AN CRYSTEN MATERIALS TECHNOLOGY CORPORATION LIMITED
    Inventors: Weixiong Zhang, Shaoli Chen, Xiaoming Chen
  • Patent number: 10913694
    Abstract: According to one or more embodiments presently disclosed, a method of catalytically converting polystyrene may include contacting polystyrene with a catalyst to form a product comprising ethylbenzene. The catalyst may include oxidized iron, oxidized cobalt, and oxidized copper. The catalyst may further include a mesoporous support material with pores having an average pore diameter of from 2 nm to 50 nm.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: February 9, 2021
    Assignees: Saudi Arabian Oil Company, King Abdullah University of Science and Technology
    Inventors: Nouf Mohammed Al-Jabri, Kuo-Wei Huang
  • Patent number: 10913695
    Abstract: The present invention relates to zeolite adsorbents based on agglomerated zeolite X crystals comprising barium, potassium and sodium. These adsorbents find applications in the separation of aromatic C8 isomer fractions and especially xylene.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: February 9, 2021
    Inventors: Catherine Laroche, Ludivine Bouvier, Javier Perez-Pellitero
  • Patent number: 10913696
    Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: February 9, 2021
    Assignees: Dow Global Technologies LLC, The Regents of the University of Michigan
    Inventors: Melanie S. Sanford, Douglas Bland, Patrick S. Hanley, Megan A. Cismesia, Sydonie D. Schimler
  • Patent number: 10913697
    Abstract: The invention relates to a process for reducing the concentration of a fluorinated alkyne impurity, such as 3,3,3-trifluoropropyne (TFPY), in 2,3,3,3-tetrafluoropropene (HFO-1234yf) which comprises contacting such a mixture with a caustic material, such as sodium hydroxide (NaOH), under conditions effective to reduce the concentration of the fluorinated alkyne impurity, including in some practices reducing the concentration by at least about 50%.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: February 9, 2021
    Assignee: Honeywell International Inc.
    Inventors: Haiyou Wang, Hsueh Sung Tung, Willie Josue Perez, Yian Zhai, Ralph John Borowski, Fang Huang Tu, Lucas Peter Labuda, John L. Welch
  • Patent number: 10913698
    Abstract: A process for conducting exothermic equilibrium reactions, especially for the performance of methanol synthesis by heterogeneously catalysed conversion of synthesis gas, is proposed, which enables readjustment and hence optimization of the reaction conditions along the longitudinal coordinate of the reactor. For this purpose, in the process according to the invention, a reactor is used which is divided into a multitude of series-connected reaction cells, each of which comprises a preheating zone, a cooled reaction zone, one or more cooling zones and a deposition zone for condensable reaction products. In this way, the reaction conditions are adjustable to the respective, local composition of the reaction mixture and variable over the reactor length.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: February 9, 2021
    Assignee: L'Air Liquide Societe Anonyme Pour L'Etude Et L'Exploitation Des Procedes Georges Claude
    Inventors: Frank Castillo-Welter, Stephane Haag, Robert Frind, Timm Schuhmann, Andreas Ochs, Marc Wagner, Solene Valentin
  • Patent number: 10913699
    Abstract: In an embodiment, a method of recovering phenol comprises heating a preheater inlet stream in a preheater to form a splitter inlet stream; separating the splitter inlet stream into a splitter top outlet stream and a splitter bottom outlet stream in a splitter column; separating the splitter bottom outlet stream into a crude top outlet stream and a crude bottom outlet stream in a crude phenol column; hydro-extracting the crude top outlet stream in a hydro-extractor column to form an extractor primary outlet stream; recovering a product phenol outlet stream from the extractor primary outlet stream in a finishing column; combining a bisphenol A plant phenol recovery stream from a bisphenol A reaction from a bisphenol A phenol purification system with the preheater inlet stream, the splitter inlet stream, the splitter bottom outlet stream, the crude top outlet stream, or a combination comprising at least one of the foregoing.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: February 9, 2021
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Mark Erik Nelson, Ahmed Abouelfetouh Youssef, Karl Aaron Baro, Paulus Johannes Maria Eijsbouts
  • Patent number: 10913700
    Abstract: A method for producing dimethylolbutanal, the method including: (A) distilling a raw material comprising dimethylolbutanal (DMB) in a distillation column; (B) separating the distilled raw material in the distillation column into a low boiling point component, dimethylolbutanal, and a high boiling point component; and (C) refluxing a portion or all of the high boiling point component to the distillation column by heating the portion or all of the high boiling point component, in which the dimethylolbutanal is separated from a side cut of the distillation column.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: February 9, 2021
    Assignee: LG CHEM, LTD.
    Inventors: Sungshik Eom, Dawon Jung, Tae Youn Kim, Dong Hyun Ko, Mi Young Kim, Min Ji Choi, Taewoo Kim
  • Patent number: 10913701
    Abstract: The present invention generally relates to processes for purification, recovery, and conversion of chlorophenol salts (e.g., 2,5-dichlorophenol and salts thereof). In various aspects, the present invention is related to removing one or more impurities from chlorophenol salt-containing process streams and/or recovering chlorophenol salts from process streams for use of the recovered chlorophenol elsewhere in an integrated process. Process streams that may be treated in accordance with the present invention include those incorporating one or more chlorophenol salts in a feed mixture and also those where one or more chlorophenol salts are present in a product or by-product stream of an integrated process. For example, conversion processes of the present invention are suitable as one piece of an integrated process for producing 3,6-dichloro-2-methoxybenzoic acid (dicamba) or a salt or ester thereof or a process for producing 2,4-dichlorophenoxyacetic acid (2,4-D) or a salt or ester thereof.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: February 9, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Howard C. Berk, Bruno de Kort, John Joseph Parlow, Amy E. Stroman, Junqiu Yang
  • Patent number: 10913702
    Abstract: A method for cycloaddition of dimethyl muconate is disclosed. According to the method, a direct transferring of a solid phase trans,trans-dimehtyl muconate into a reactor pre-filled with ethylene gas increases the efficiency of the reaction and suppress side reactions resulting an improvements in yield and purity. Furthermore, the method is capable of obtaining a high yield of dimethylcyclohex-2-en-1,4-dicarboxylate at a lower cost, and therefore is also useful for the mass synthesis of dimethyl terephthalate.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 9, 2021
    Assignee: SK CHEMICALS CO.. LTD.
    Inventors: Jae Kyun Park, Jeong Ho Park, Hee-il Chae
  • Patent number: 10913703
    Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 9, 2021
    Assignee: NABRIVA THERAPEUTICS GMBH
    Inventors: Werner Heilmayer, Lee Spence, Peter Hinsmann
  • Patent number: 10913704
    Abstract: The present invention relates to 2,3,7-Trimethyloct-6-enyl acetate and 3,7-dimethyl-2-methylene-oct-6-enyl acetate and derivatives thereof and their use as aroma chemicals.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: February 9, 2021
    Inventors: Volker Hickmann, Stefan Ruedenauer, Ralf Pelzer, Vijay Narayanan Swaminathan, Shrirang Hindalekar, Nitin Gupte, Sadanand Ardekar, Mileen Kadam
  • Patent number: 10913705
    Abstract: The invention describes hydrosoluble iron (III) oxyhydroxide complexes prepared from different sources of iron, amino acids and carboxylic acids. The iron (III) complexes have no undesirable residual taste and can be used as supplementation forms for the prevention or treatment of iron deficiency anemia in humans or animals and pharmaceutical or food compositions containing them.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: February 9, 2021
    Assignee: NPA—NÚCLEO DE PESQUISAS APLICADAS LTDA
    Inventors: Ricardo Da Silva Sercheli, Nelson Henriques Fernandes, Nelson Henriques Fernandes Filho
  • Patent number: 10913706
    Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: February 9, 2021
    Assignee: CITY OF HOPE
    Inventors: Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
  • Patent number: 10913707
    Abstract: This invention relates to a process for preparing electron deficient olefins, such as 2-cyanoacrylates, using an acid catalyzed two-step process including an esterification reaction followed by a Knoevenagel condensation reaction.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: February 9, 2021
    Assignee: Henkel IP & Holding GmbH
    Inventors: Cormac Duffy, Marisa Phelan, Barry Burns
  • Patent number: 10913708
    Abstract: This invention relates to a process for producing electron deficient olefin precursors, such as 2-cyanoacetates, using an acid catalyzed esterification reaction.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: February 9, 2021
    Assignee: Henkel IP & Holding GmbH
    Inventors: Cormac Duffy, Marisa Phelan, Barry Burns
  • Patent number: 10913709
    Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: February 9, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, GLG Pharma, LLC, MRIGlobal
    Inventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
  • Patent number: 10913710
    Abstract: The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6? and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6? to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: February 9, 2021
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    Inventors: Herbert Waldmann, Pablo Antonio Martin-Gago, Sandip Murarka, Christian Klein, Philippe Bastiaens, Alfred Wittinghofer, Eyad Kalawy Fansa
  • Patent number: 10913711
    Abstract: Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 9, 2021
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Amy Hauck Newman, Oluyomi M. Okunola-Bakare, Jianjing Cao
  • Patent number: 10913712
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: February 9, 2021
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • Patent number: 10913713
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: February 9, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Michael Reardon, Richard A. Silva
  • Patent number: 10913714
    Abstract: The present invention relates to a new pyrrole sulfonyl derivative, and a preparation method and medical use thereof. In particular, the present invention relates to a pyrrole sulfonyl derivative as represented by general formula (I), a preparation method thereof, a pharmaceutical composition comprising the derivative, and a use thereof as a therapeutic agent, in particular as a gastric acid secretion inhibitor and as potassium-competitive acid blockers (P-CABs), wherein each substituent group of general formula (I) is the same as that defined in the description.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: February 9, 2021
    Assignees: JIANGSU CAREPHAR PHARMACEUTICAL CO., LTD, NANJING CAREPHAR SHENGHUI PHARMACEUTICAL CO., LTD
    Inventors: Yinlin Qin, Mei Su, Qiu Jin, Tao Chen, Jianhua Jiang
  • Patent number: 10913715
    Abstract: The present invention provides a novel crystalline form I of hydrochloride, a crystalline form II of hydrochloride, a crystalline form of succinate, a crystalline form of tartrate, a crystalline form I of fumarate and a crystalline form II of fumarate of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine. The above-described novel crystalline forms have high solubility in water and excellent stability under moisture-proof conditions and high-humidity exposure conditions, and thus can be pharmaceutically used.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: February 9, 2021
    Assignee: Daewoong Pharmaceutical Co., Ltd.
    Inventors: Aeri Kim, Kwan Hyung Cho
  • Patent number: 10913716
    Abstract: The present invention concerns substituted indoline compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: February 9, 2021
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson, Jean-François Bonfanti, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Patent number: 10913717
    Abstract: The present invention, relates to solid state forms of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.
    Type: Grant
    Filed: December 7, 2019
    Date of Patent: February 9, 2021
    Assignee: MSN LABORATORIES PRIVATE LIMITED
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkat Reddy Ghojala, Pradeep Rebelli
  • Patent number: 10913718
    Abstract: A molecular building block composition can include a metal ion component; and a ligand component including a core including at least one functional group associated with the metal ion component and the core.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: February 9, 2021
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Mohamed Eddaoudi, Dongxu Xue, Ryan Luebke, Vincent Guillerm, Abdul Malik Puthan Peedikakkal, Karim Adil, Lukasz Weselinski
  • Patent number: 10913719
    Abstract: Disclosed is a process for preparing a compound of Formula 1, from a compound of Formula 2 wherein X, R1, R2, R3, R4, R5, n, R6, R7, G and W are as defined in the disclosure. Also disclosed are compounds of Formulae 2 and 4 wherein X, R1, R2, R3, R4, R5, n, R6, R7, G and W are as defined in the disclosure. Also disclosed is a process for preparing the compounds of Formulae 2 and 4.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: February 9, 2021
    Assignee: FMC Corporation
    Inventors: Thomas Paul Selby, Kanu Maganbhai Patel, Thomas Martin Stevenson
  • Patent number: 10913720
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R, R1, R2, R3, m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: February 9, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Holger Wagner
  • Patent number: 10913721
    Abstract: The present invention relates to a crystalline form N of aripiprazole, pharmaceutical compositions thereof and the use of crystalline form N in the preparation of a medicament for the treatment of central nervous system diseases, especially schizophrenia.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: February 9, 2021
    Assignee: NANJING NORATECH PHARMACEUTICALS CO., LTD
    Inventors: Yun-Zhe Sun, Wei-Ming Jiang, Xin Zhao, Cheng-Gang Lin, Li Gui, Fei Liu