Abstract: A wearable device is disclosed. The wearable device may process a state variable defined based on motion information of a user, determine an interactive mode of the wearable device based on a gain associated with a magnitude of a torque of the wearable device, select a motion type from among motion types of the determined interactive mode based on a gait parameter of the user, determine a control factor for the torque based on the selected motion type, and generate the torque based on the processed state variable, the gain, and the determined control factor.

Abstract: A control method of a walking assistance apparatus is disclosed. The control method of the walking assistance apparatus includes estimating an operable time of the walking assistance apparatus based on an amount of remaining power and power consumption of the walking assistance apparatus, determining whether the operable time satisfies a preset criterion, and generating a torque profile based on an algorithm of a power saving mode when the preset criterion is satisfied.

Abstract: According to some embodiments, a device configured for self-administered therapy comprises at least two base members, each base member configured to be secured to a surface for mounting the device of said surface, a shaft configured to secure to the at least two base members and extend between the at least two base members, and at least one therapy member configured to be secured relative to the shaft, wherein the at least one therapy member is configured to rotate relative to the shaft during use, wherein the at least one therapy member is configured to be contacted by a user and configured to rotate during use.

Abstract: The present invention relates to an automated massage apparatus (10) having a substantially horizontal bed (20) which provides a massage surface (12). A massage element or roller (14) can move relative to the massage surface to provide an automated massage to the whole or selected parts of the body of a user lying upon the bed.

Abstract: A device (5) it is provided for cooperating with a handpiece (1) of a ballistic waves generating system for the treatment of a portion of tissue (4) of a patient, the handpiece (5) comprising a supporting member (30) on top of which an end member (3) it is arranged to come into contact with the said portion of tissue (4) of the patient, the device (5) it is characterized in that it comprises supporting means (50) of terminal means (51), said supporting means (50) being adapted to be mounted onto said supporting member (30), and said terminal means (51) being able to come into contact with the tissue portion (4) of the patient.

Abstract: An artificial intelligence massage apparatus for controlling a massage operation according to an embodiment of the present disclosure includes a microphone, a camera, a driver comprising at least one motor, and a processor configured to obtain image data including a face of a user via the camera, determine whether the user is uttering using the obtained image data, obtain speech data via the microphone, if it is determined that the user is uttering, generate intention information corresponding to the obtained speech data, and control a massage operation based on the generated intention information by controlling the driver.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: A system, method and device for providing sound-based therapies to a user. The system, method, and device employ an initial measurement about a user (either or both distances on said user's head or recorded sound), a determination of a resonant frequency, and a wearable actuator affixed on said user's person with the ability to provide a unique resonant frequency to the user. The aspects disclosed herein may also incorporate microphones to optimize and monitor the treatment.

Abstract: An apparatus for assisting a rescuer in performing chest compressions during CPR on a victim, the apparatus comprising a pad or other structure configured to be applied to the chest near or at the location at which the rescuer applies force to produce the chest compressions, at least one sensor connected to the pad, the sensor being configured to sense movement of the chest or force applied to the chest, processing circuitry for processing the output of the sensor to determine whether the rescuer is substantially releasing the chest following chest compressions, and at least one prompting element connected to the processing circuitry for providing the rescuer with information as to whether the chest is being substantially released following chest compressions.

Abstract: A container holding device for holding one or more containers includes: a base plate having an upper surface, a bottom surface, and one or more holes each extending from the upper surface to the bottom surface and having a central symmetry axis Laxis orthogonal to the base plate; and two or more holding elements that are located around each hole beneath the bottom surface of the base plate. The holding elements are configured to: contact an outer surface of a container that is placed into the container holding device at a bottom edge of a top region of the container, such that the container hangs in the container holding device in a first position p1 in which the holding elements do not exert any force on the outer surface of the container that is radial; and contact the outer surface of the container in a shoulder region.

Abstract: A system including an adapter for sequential engagement with a cartridge containing a first substance and a vial containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member engageable with a portion of the cartridge. A plunger rod includes a protrusion and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.

Abstract: In one aspect the invention provides an adherence monitoring device for a medication delivery device, the monitoring device including at least one inductive coil sensor which includes at least one inductive controller, at least two inductive coils including a first inductive coil coupled to the housing and a second inductive coil coupled to the housing. The first inductive coil is configured to exhibit a response to an inductive change and provide a first change signal in response to an inductive change, and the second inductive coil is configured to exhibit a response to the inductive change and provide a second change signal in response to the inductive change.

Abstract: A product interaction monitor includes sensors for measuring characteristics related to the product and/or product package or other type of container. The product interaction monitor can be installed in a container cap and used to monitor events associated with the container such as product usage. The product interaction monitor can utilize multiple sensor outputs to increase the accuracy of the detection of the events. The product interaction monitor can be used to estimate product inventory or product usage and communicate information regarding the product and/or product usage to a local display or a remote computer.

Abstract: Described herein is a baby bottle formula mixing and feeding assembly designed to be coupled to a standard baby feeding bottle or powder mixing bottle. The formula mixing assembly is designed to include at least four main components: a bottom housing, a cylindrical gate body, a top housing and a cylindrical pliable cup body disposed within the top/bottom housing. A locking mechanism is included that unlocks the top housing and the gate body containing the pliable cup body and the formula, such that the apertures in the gate body align with the apertures in the bottom housing to when the top housing is rotated so as to empty the formula contents into the bottle with the liquid. e both the bottom housing and the gate body.

Abstract: A breastfeeding device is disclosed comprising a liquid pouch assembly, a silicone housing, a silicone areola, and an adjustable strap. The liquid pouch assembly comprises a nipple removably coupled to an amorphous liquid bag. The silicone housing comprises a silicone cup and a rear silicone component attached to one another and forming an interior cavity. An entrance to the cavity is formed at the top of the silicone cup and the rear silicone component, and the liquid pouch assembly is insertable through the entrance. The silicone cup includes a central hole. The nipple of the liquid pouch assembly is insertable into the central hole and protrudes through the central hole while the amorphous liquid bag remains within the interior cavity. The silicone areola is external to the silicone housing, and the silicone areola is removably coupled to the nipple and concentric with the central hole of the silicone cup.

Abstract: A teat for use with a fluid container comprises a deformable mouthpiece for an infant to suck on during a fluid intake action and an inner core (20) disposed within the mouthpiece. An exterior surface (21) of the inner core (20) is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face (22) of the exterior surface (21) of the inner core (20) so that a fluid duct between the mouthpiece and the inner core (20) is defined which allows the infant to perform a peristaltic fluid intake action. At least one of the interior surface of the mouthpiece and the exterior surface (21) of the inner core (20) has at least one protrusion (23) that is designed to form a fluid barrier between the mouthpiece and the inner core (20) at a position for delimiting the fluid duct at the sides thereof.

Abstract: A feeding bottle teat includes a body having an interior cavity and an exterior surface, an inlet including a flange for engagement within an aperture of a feeding bottle cap in use, and a nipple including one or more outlet apertures wherein the flange, cavity, nipple and apertures form a passageway for delivery of milk from the bottle in use, wherein a transverse dimension of the interior surface of the body at the inlet is greater than a transverse dimension at the nipple, and wherein the interior surface includes a plurality of concentric strengthening formations extending inwardly from the inner surface between the inlet and the nipple, wherein the strengthening formations comprise coaxial concentric spirals which rotate about a common central axis, wherein each strengthening member comprises a spiral having two to four rotations about the central axis.

Abstract: The invention relates to a one-part dental adhesive composition comprising polymerizable component(s) with an acidic moiety as Component A, photo-initiator(s) as Component B1, transition metal ion component(s) as Component C, solvent(s) other than water as Component D1, a stabilizer as Component E, the stabilizer comprising a free radical moiety or being selected from anaerobic stabilizers, for use in a process of fixing a composite material to the surface of hard dental tissue, the composite material comprising a redox initiator system with an oxidizing agent and a reducing agent.

Abstract: The invention relates to a root canal filling composition for placement in a tooth root canal, a kit for providing the required materials, and a method for applying the materials. It is provided that the root canal filling composition comprises a glass-fibre post and a dentine-adhesive filling material.

Abstract: A method for producing a powder lead is disclosed, wherein at least one colourant, at least one filler and at least one binder are mixed with a carrier liquid, leads are shaped from the wet compound, the leads shaped in step b) are guided through a chamber in which they are exposed to a pulverulent covering agent, and the powdered leads are guided into a drying apparatus and dried therein.

Abstract: An SPF booster is provided, comprising: a multistage polymeric particle having a core comprising polymerized units of a monoethylenically unsaturated carboxylic acid core monomer and a non-ionic ethylenically unsaturated core monomer; an inner shell comprising polymerized units of a non-ionic ethylenically unsaturated inner shell monomer; a monoethylenically unsaturated carboxylic acid inner shell monomer and an aliphatic inner shell monomer; an outer shell comprising polymerized units of a non-ionic ethylenically unsaturated outer shell monomer; an aliphatic outer shell monomer; a monoethylenically unsaturated non-carboxylic acid outer shell monomer and an ethylenically unsaturated surfactant outer shell monomer; wherein the core, when dry, contains a void; and wherein the multistage polymeric particle has an average particle size, when dry, of 50 to 1,000 nm.

Abstract: The present disclosure provides an oral care composition including a water-miscible base component, an amorphous calcium phosphate remineralizing component including a water-soluble or partially water-soluble calcium component and a water-soluble inorganic phosphate component, and a tartar control component, wherein the oral care composition provides enamel fluoride uptake activity and tartar control activity.

Abstract: The invention is directed to a three-part bleaching composition and method comprising pigments in a third composition. It has unexpectedly been found that an third composition comprising pigments increase the contrast between bleaching composition and keratin fibers to a degree which allows for a more accurate judgement of the desired end point of bleaching during the bleaching process.

Abstract: Oral care compositions and methods for reducing dental sensitivity or at least partially occluding dentin tubules of teeth in a subject are described herein. The oral care compositions may include an orally acceptable vehicle and a silica blocking agent configured to at least partially occlude dentin tubules of teeth. The silica blocking agents may include silica particles having a particle size distribution (D95) less than or equal to 7 ?m and a BET surface area of greater than or equal to 150 m2/g.

Abstract: A Pickering formulation for use as a pharmaceutical or cosmetic composition for regenerating skin cells, allowing reducing skin stretch marks on a human skin, or healing skin cells after a burn, such as a sunburn. The Pickering formulation comprises an emulsion of oil and water phases stabilized with an organic-modified natural physosillicate, such as hectorite, montmori-Uonite, or bentonite. The pharmaceutical or cosmetic composition can be free of primary emulsifier or primary surfactant reducing as such the toxicity of the composition for the skin. As such, the pharmaceutical or cosmetic composition may consist essentially of the Pickering formulation. Indeed, it is demonstrated that the Pickering formulation can act itself as an active ingredient of the pharmaceutical or cosmetic composition leading to significant skin cell regeneration. The invention is particularly useful for reduction of stretchmarks. The Pickering formulation also boosts the sun protection factor, or SFP, of sunscreen compositions.

Abstract: The invention relates generally to liquids such as mouth rinses for the prevention and elimination of bad breath as well as for the reduction of oral microorganisms responsible for the development of dental plaque and tooth decay. In particular, the present invention relates to a method of preparing non-alcohol or reduced alcohol mouth rinses effective at preventing the above-mentioned problems.

Abstract: Suggested are 1,2-alkanediols of formula (I) HOCH2—CH(OH)—R1 in which R1 stands for an alkyl radical having 3 to 10 carbon atoms, said diols being substantially free of lactones and/or peroxides.

Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.

Abstract: The present invention relates to a cosmetic preparation containing 4-(tert.-butyl)-4?-methoxydibenzoylmethane which is encapsulated with cellulose acetate, and to methods and uses of 4-(tert.-butyl)-4?-methoxydibenzoylmethane which is encapsulated with cellulose acetate.

Abstract: A composition that includes a novel association of antioxidant acids demonstrates an unexpected synergistic antioxidant effect that is relevant for the topical treatment of signs of aging and reducing cutaneous lipid peroxidation. The composition includes (a) gallic acid, (b) ferulic acid, (c) ascorbic acid (Vitamin C), and (d) salicylic acid, all present in the composition in amounts sufficient to produce the synergistic antioxidant activity. In some embodiments, gallic acid is present in an amount that is in the range from about 1% to about 10%, and in some examples, in an amount that is at least about 5%.

Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.

Abstract: A system and method for dyeing and/or lightening keratin-containing fibers, as well as a lightening composition for use in such a system and method are described, which are able to provide a high levels of lift while avoiding irritation and/or soothing the scalp. The system and method include a first composition, which may be a lightening composition. That composition includes (i) at least two alkali components for lightening keratin-containing fibers, wherein one of the at least two alkali components comprises sodium metasilicate and/or a metasilicate salt, and the composition comprises about 0.1 to about 10 weight percent of the at least two alkali components; and (ii) an arginine compound, wherein the arginine compound is present in an amount that would be effective to reduce irritation to a surface of a mammal having keratin-containing fibers. The system and method also include an oxidizing agent composition comprising an oxidizing agent, wherein the system has a pH of at least about 9 to about 12.

Abstract: The present invention relates to a personal care composition comprising a combination of 1-piperidinepropionic acid and pyridinecarboxamide. The composition provides synergistic skin lightening.

Abstract: A hair cosmetic that has a better color when performing hair dye includes a hair cosmetic composition containing an alkali agent, an amino acid, a higher alcohol having 12 to 22 carbon atoms, a surfactant, and a thickener. The alkaline agent may be at least one of aqueous ammonia, ammonium carbonate, sodium carbonate, ethanolamines, ammonium bicarbonate, and arginine.

Abstract: The invention provides a tanning composition for oral administration by humans, the composition being a chewable pastille comprising: (i) a chewable base comprising a gelling agent and a sugar and/or sugar alcohol; and (ii) one or more skin colour-promoting agents. The sugar is typically a mixture of glucose and sucrose. The gelling agent may be is selected from gelatin, pectin, agar, alginate and carrageenan, and mixtures thereof. The skin colour-promoting agents may comprise one or more of the carotenoids ?-carotene, lycopene, zeaxanthin, lutein and astaxanthin, tyrosine, PABA and copper.

Abstract: Disclosed are a pharmaceutical composition and a beauty-purposed pharmaceutical composition for prevention or treatment of neuromuscular disease, the composition including a combination of Erigeron annuus flower-based essential oil and Botox. Erigeron annuus flower-based essential oil inhibits t-SNARE protein and v-SNARE protein expression in neurons to inhibit the formation of SNARE protein complexes. Erigeron annuus flower-based essential oil inhibits the regeneration of t-SNARE protein and v-SNARE protein degraded by Botox to inhibit neurotransmitter release. Accordingly, an efficacy duration of Botox may be extended. Thus, Erigeron annuus flower-based essential oil may be usefully used in combination with Botox as Botox adjuvant for the prevention and treatment of neuromuscular disease or for beauty.

Abstract: Disclosed is a complex including at least one lactoferrin and at least one silica having a specific surface area included between 100 m2/g and 1000 m2/g (BET area, measured according to standard ISO 9277-2010), the complex being obtainable by adding the lactoferrin to the silica in the form of a sol-gel with an aqueous solvent, and subsequent drying of the sol-gel. The complex is particularly suitable for use in oral care products, in particular toothpastes, mouthwashes, gels, chewing gum, tablets for use in oral care, gingival dyes, and the like. The complex features a high level of stability and bio-availability, such that it has an effective, long-lasting antibacterial and antioxidant action within the oral cavity. The complex is particularly suitable for the prevention or treatment of diseases of dental apparatus, in particular for the prevention or treatment of periodontitis or peri-implantitis, preferably in patients suffering from diabetes.

Abstract: Disclosed is a composition comprising at least one core-shell microcapsule in a suspending medium. The microcapsule comprises a core and a shell around said core. The shell comprises a hyperbranched polysaccharide selected from the group consisting of amylopectins, dextrins, hyperbranched starches, glycogen and phytoglycogen and mixtures thereof.

Abstract: A cosmetic includes a component (a) and (b): wherein component (a) is a polyacrylic acid or a salt thereof or poly(2-acrylamido-2-methylpropanesulfonic acid) or a salt thereof that has a weight-average molecular weight of 500,000 to 8,000,000, is linear, and has a thread length of 10 mm or less at room temperature when formed into a 1% by mass solution, wherein the thread length is a distance determined by: bringing a round disk having a diameter of about 1 cm uniformly and lightly into contact with a surface of the solution; lowering a container that contains the solution at a velocity of 5 mm/sec, and measuring the distance that the container descended until a thread of the solution is cut, and component (b) is a crosslinked water-swellable polymer having a crosslinking density of 0.01 to 1% by mole, or a microgel obtained by pulverizing a gel consisting of a hydrophilic compound having gelating ability.

Abstract: A thickener for a non-aqueous system includes a water-soluble polymer and a counterpart that ionically and/or electrostatically interacts with the water-soluble polymer.

Abstract: The present invention addresses the problem of providing a massage oil capable of alleviating pain of the muscles, joints, nerves, etc. In order to solve this problem, there is provided a massage candle that has a container, a wax component accommodated in the container, and a wick inserted into the wax component, wherein the melting point of the wax component is 30-60° C., the wax component contains 40% by weight or more of shea fat and also contains 15-40% by weight of vegetable oil that is liquid at normal temperature, and the massage candle is for alleviating pain.

Abstract: A method for reducing a presence of sebum on skin, reducing an appearance of shiny skin, or reducing an appearance of the size of skin pores is disclosed. The method can include topically applying to skin a composition comprising a navy bean extract comprising amino acids, an extract of Bambusa vulgaris wendl shoots, and charcoal.

Abstract: The present invention provides topical formulations having an autophagy stimulating and/or heme oxygenase and activating/triggering effect on human skin for cosmetic and pharmaceutical use. Furthermore, the present invention provides topical formulations that trigger production of VEGF-C, reduce melanin synthesis and boost energy and cell function. Moreover, the present invention provides a new process for producing a herbal composition comprising a mixture of components of Bellis perennis L. and optionally Hieracium pilosella by aqueous extraction and the herbal composition comprising a mixture of components produced by the process of the present invention. The pharmaceutical formulations according to the present invention may be used for the treatment or prevention of dark circles under the eye and/or puffy eyes. The herbal composition according to the present invention may also be used in a cosmetic formulation for the cosmetic treatment or prevention of dark circles under the eye and/or puffy eyes.

Abstract: The present disclosure relates to the field of oral mucoadhesive dosage forms and the type and amounts of structural components to improve mucoadhesion. The present disclosure further relates to combinations of active ingredients within a mucoadhesive dosage form.

Abstract: Fixed dose HER2 antibody formulations for subcutaneous administration are provided along with their use in the treatment of cancer. The formulations include fixed dose subcutaneous formulations of pertuzumab and subcutaneous co-formulations of pertuzumab and trastuzumab, and their use in the treatment of cancer.

Abstract: Microneedle and microneedle devices including implantable silk-based tips for sustained dermal delivery of a vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a vaccine (e.g., an influenza vaccine) to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described.

Abstract: Embodiments of the invention involve treating ophthalmology conditions by the topical or oral use of acetylcholinesterase inhibitors. By effectively reducing or eliminating the population of Demodex mites in affected areas and areas where Demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the ophthalmological afflictions than any previously described method. Embodiments of the invention are useful for treating ocular afflictions caused by Demodex-induced inflammatory eye conditions, including meibomian gland dysfunction, conjunctivitis, keratoconjunctivitis, hyperemia, blepharitis and dry eye disease.

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Abstract: Methods of delivering cromolyn to a patient in need thereof, methods of treating amyloid-associated conditions and inflammatory or allergic lung diseases, and packs and kits comprising cromolyn are described.

Abstract: An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.