Abstract: A method of using RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

Abstract: The present inventions relates to an isolated nucleic acid molecule comprising a nucleotide sequence coding for a depolarizing light-gated ion channel functionally linked to a promoter leading to the specific expression of said depolarizing light-gated ion channel in a retinal photoreceptor, or the nucleotide sequence complementary to said nucleotide sequence, for use in treating or ameliorating blindness. The present invention also relates to methods of using such nucleic acid molecules in the treatment of blindness.

Abstract: The presently-disclosed subject matter includes fluorescent compounds of the following formula: The compounds can be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.

Abstract: Provided is use of miR-21 in preparation of a therapeutic drug or diagnostic reagent for intrauterine adhesion and/or thin endometrium.

Abstract: The present invention is intended to provide a peptide that selectively binds to a metal surface. The present invention relates to a peptide consisting of an amino acid sequence as set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, or SEQ ID NO: 21, or a peptide substantially identical to the aforementioned peptide, and a method for detecting a metal surface of a medical device, using these peptides.

Abstract: The present technology provides compounds as well as compositions including such compounds useful for the treatment of cancers where the compounds are represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein M is an alpha-emitting radionuclide.

Abstract: The present invention relates to a vaccine composition for use in in vivo administration, comprising a (attenuated) pathogen or commensal modified to be a pre-targeting vector, the pre-targeting vector comprising one or more pendent reactive moieties able to form a high affinity interaction with a complementary moiety residing on an immunogenic conjugate component.

Abstract: Methods, systems, and apparatuses involving disinfecting light subcomponents are provided. An example system comprises a substrate with one or more light emitters disposed on the substrate. The one or more light emitters may be configured to inactivate microorganisms on a surface by emitting light. The light may comprise a proportion of spectral energy of the light, measured in a 380 nanometers (nm) to 420 nm wavelength range, greater than 50%. The light may comprise a full width half max (FWHM) emission spectrum of less than 20 nm and centered at a wavelength of approximately 405 nm to concentrate a spectral energy of the light and minimize energy associated with wavelengths that bleed into an ultraviolet wavelength range. The light may comprise an irradiance at the surface sufficient to initiate inactivation of microorganisms on the surface.

Abstract: Apparatus for measuring a dosage of disinfection light. The apparatus includes: a measurement pad including a photochromic material that changes its color in response to a dosage of disinfection light incident on the measurement pad; and a dosage scale bar having a plurality of units that have different colors, wherein the dosage of the disinfection light is determined by comparing the color of the measurement pad with the different colors of the plurality of units.

Abstract: An ultraviolet C (UV-C) disinfection device includes a UV-C light-emitting diode (LED) illuminator which includes a UV-C source module and a UV-C LED coupling module. The UV-C source module includes a heat spreader and a UV LED chip that is mounted on the heat spreader which is configured to be mounted on a printed circuit board (PCB). The UV-C LED coupling module includes a holder and a rod configured to carry a UV-C light emitted from the UV-C LED chip from a first distal end of the rod to an opposite second distal end of the rod such that the UV-C light gets leaks out from a side of the rod to deliver at least a portion of the UV-C light to a surrounding of the rod, with the rod secured with the holder positioning the rod onto the UV-C chip.

Abstract: Disclosed is a portable sterilization case for personal protective equipment and small articles, such as a mobile phone. The portable sterilization case includes a box body having an opening and inner volume for receiving the articles. The portable sterilization case further includes a cover coupled to the box body forming an enclosed case. The cover is coupled through a hinge joint allowing the cover to pivot in an open position and close position. The inner sides of each the box body and the cover can have an integrated ultraviolet (UV) lamp having a UV-C spectrum configuration. The portable sterilization case further includes a lock member for securing the cover to the box body. In one case, the lock member can be a magnet/magnet pair or magnet/iron pair.

Abstract: A system for sterilizing biological material comprising beam generation circuitry for generating a radiating wave having radiating energy therein at a predetermined frequency therein. A controller controls the radiating wave generation at the predetermined frequency. The predetermined frequency equals a resonance frequency of a particular biological material and is determined responsive to a plurality of parameters from an influenza virus. The predetermined frequency induces a mechanical resonance vibration at the resonance frequency of the particular biological material within the particular biological material for destroying a capsid of the particular biological material. Radiating circuitry projects the radiating wave on a predetermined location to destroy the particular biological material at the predetermined location.

Abstract: A disposable antiseptic wipe apparatus includes a bacteria-proof packaging container having an interior compartment. An antiseptic wipe is infused with an antiseptic material and positioned within the interior compartment. The antiseptic wipe has a rolled cylindrical shape. A portion of packaging container is removable from the antiseptic wipe to exposed one end of the rolled, cylindrical shape of the antiseptic wipe while an unexposed end of the rolled, cylindrical shape of the antiseptic wipe is graspable by a user through the packaging container.

Abstract: The present disclosure relates to a sanitary mask storage, and more particularly, to a sanitary mask storage having a disposable mask for personal hygiene (including, for example, fine dust and yellow dust masks) dehumidified, antibacterialized, and deodorized when storing the disposable mask, thereby allowing hygienic storage for the disposable mask to be reused several times.

Abstract: The present invention is directed to a gas scrubbing process for removing at least one odorous vaporous compound from a gas stream generated by a rendering process or at least reducing the concentration of that odorous vaporous compound. In one embodiment, a series of two gas/liquid contactors is used, each having a different liquid scrubbing solution, with one scrubbing solution controlled at an alkaline pH and the other scrubbing solution controlled at an acidic pH. In another embodiment, the pH of the respective scrubbing solutions in each of the two gas/liquid contactors is reversed.

Abstract: Embodiments described herein relate to a system and method for germicidally irradiating a waste receptacle or other receptacle that fosters microbial growth. A system for treating a waste receptacle may include a housing; a power source disposed about the housing for providing power; and a germicidal source energetically coupled to the power source for irradiating the waste receptacle. The waste receptacle may be a garbage disposal. The germicidal source may be an ultraviolet lamp. A method for treating a waste receptacle may include providing a housing; providing a power source disposed about the housing for providing power; and providing a germicidal lamp energetically coupled to the power source for irradiating the waste receptacle.

Abstract: Antimicrobial material which is a composite of a matrix component comprising a flexible hydrophilic polymer foam or fiber matrix comprising two matrix faces providing a release face and a reverse face or two release faces, and therebetween a structural matrix framework defining a network of cells having a cell network surface and therein a network of pores or cell openings, and a powder charge component comprising antimicrobial additive or wound care additive, wherein said powder charge is comprised at one said release face or both said faces and/or within said cell network wherein said composite is an assembly of preformed matrix component and powder charge component; and asymmetric material which is asymmetric having regard to distribution of said powder charge therein; and material wherein said power charge comprises flowing agent and/or bulking agent and/or binder and wherein said additive and/or flowing agent is co-located with said bulking agent and/or said binder; devices comprising said composite, met

Abstract: A hemostatic material containing cationized cellulose and a wound dressing containing the hemostatic are provided. At least one of hydroxyl groups of the cationized cellulose is modified with —R2—N+(R3)(R4)(R5).X?, other hydroxyl groups of the cationized cellulose have —H, or —(CH2CH2O)m—H, R2 represents C1-6 alkylene, C2-6 hydroxyalkylene, —(CH2CH2O)l—, or a combination thereof, l represents 1 or 2, m represents 1 or 2, and X? may represent an anionic group.

Abstract: In the field of medicine and medical technology, improving the technical properties of the surgical suture material. Composite surgical suture material includes titanium monothreads combined in a polyfilament thread, wherein a bioresorbable polymer material is present in the gaps between the monothreads and on their surface, and the monothreads have a relief surface. The technical result increases the strength, elasticity and plasticity of the suture material, the absence of a “sawing” effect on tissues, an increase in the sliding friction coefficient, and also in ensuring capability of carrying antibacterial and other medicinal substances in its structure, in ensuring a long-term presence in the body and possessing a high biological inertness in the late postoperative period, which excludes the initiation and persistence of aseptic inflammation associated with the presence of the material in the body.

Abstract: Hydrocolloid composition and bio-patch comprising the same are provided. The hydrocolloid composition has a hydrophobic elastomer matrix. Hydrocolloid particles and aerogel particles are dispersed in the matrix. The aerogel particles may be silica aerogel particles. The aerogel particles may include particles having hydrophobic functional groups formed on the particle surface. The aerogel particles may be hydrophobic aerogel particles, hybrid aerogel particles in which hydrophobic functional groups and hydrophilic functional groups are simultaneously formed on the particle surface, or a mixture of the hydrophobic aerogel particles, the hybrid aerogel particles, and hydrophilic aerogel particles.

Abstract: A novel hydrogel wound dressing therapy and methods for making the same. The novel methods comprise forming two biopolymers, chitosan and hyaluronic acid, together into a wound dressing with inherent ability to enhance wound closure. The novel composition of the subject invention comprises cross-linked chitosan/hyaluronic acid hydrogels manufactured according to the methods disclosed having a specific cross-link density that results in a swelling ratio of 20 to 100. Hydrogels manufactured in accordance with the method of the invention dramatically increase healing rates and greatly improves outcomes of wound injuries.

Abstract: A heart valve is at least partially constructed from a block-copolymer, the block-copolymer having a phase structure formed by its constituent blocks, and wherein the phase structure is arranged so as to produce anisotropic physical properties in the heart valve.

Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.

Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.

Abstract: Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.

Abstract: The present invention provides a multilayer matrix comprising at least two layers in which the first layer comprises a bioresorbable material and the second layer comprises a bioadhesive material, wherein the second layer contains cells. A method for producing a multilayer matrix and the use of a multilayer matrix are also provided.

Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Abstract: A vascular prosthesis (1) for connection to a natural cardiovascular system, includes a volume chamber (2), wherein the volume chamber (2) has, in a blood pressure range below a pressure threshold value D, a pressure-expansion behavior substantially corresponding to the pressure-expansion behavior of a natural blood vessel, while the volume of the volume chamber (2), depending on the pressure, increases by at least 10 cm3 in a blood pressure range above the pressure threshold value D. The vascular prosthesis (1) is configured as a textile tube, wherein the textile tube includes in the region of the volume chamber (2) an elastic yarn having a core made from silicone yarn around which a yarn made from polyethylene terephthalate (PET) is wrapped.

Abstract: The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.

Abstract: In the field of medicine and medical technology, improving the technical properties of endoprostheses used for the surgical treatment of hernias. A self-expanding mesh endoprosthesis for endoscopic hernioplasty includes a mesh fabric made of threads and a self-expanding system incorporated in the mesh fabric, wherein the self-expanding system is made of polyfilament titanium threads located both in the structure and along the contour of the endoprosthesis, and wherein the titanium threads of the mesh fabric are made with a relief surface. The technical result increases efficiency of performing laparoscopic hernioplasty operations, increasing the plasticity, and reducing the risk of breakage of the threads in the mesh structure, simplifying the surgical technique for passing through and placement of the endoprosthesis, reducing the duration and trauma of surgery and, accordingly, accelerating the recovery of patients.

Abstract: In the field of medicine and medical technology, improving technical mesh implant for hernioplasty. A self-fixing mesh implant includes two layers, upper and lower, with a layer of mesh based on titanium thread on the upper side, and a layer of bioresorbable polymers on the lower side, wherein the surface of the titanium thread is made in relief. The technical result increases the efficiency of fixing the implant in the operating field, increases the plasticity and reducing the risk of implant threads breakage, increases the simplicity and strength of fixation, ensures the uniformity of fixing the implant with the entire surface thereof to the tissues of the operating wound, reduces the duration of surgery, and, as a consequence, reduces the volume of anesthesia and trauma, leading to a decrease in the rate of complications.

Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

Abstract: The invention relates to a medical device for use in human vessels, in particular in the carotid artery, comprising: a self-expandable mesh structure which at least partially forms a curved wall, and has, in a radially compressed state, a cross-sectional diameter of not more than 2.5 mm, wherein the mesh structure is formed of at least one mesh structural element which has a height that is no more than 200 ?m, in particular no more than 150 ?m, preferably no more than 70 ?m, where the height is measurable along a diameter of the mesh structure, and wherein the mesh structure is at least partially formed of a nickel titanium alloy and is at least partially coated in fibrin.

Abstract: The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.

Abstract: A device, system, and method for relaxing jaw muscles of a user. The device has a tooth engaging portion which operates by stretching the users jaw in the open position, thereby simulating a yawn. The device may be optimized to be used as a dental tool having a suction end. The system may include a computer program having stored or downloaded guided meditation programs, soothing sounds, inspirational messages, or similar. The system may also include a reminder that reminds the user to perform the task via a smart device. Further, the device may be used as a method of preventing or treating migraine headaches by relieving stress and relaxing the user.

Abstract: A wound therapy system is configured to deliver fluid to a wound site and remove fluid from the wound site. The wound therapy system includes a combined fluid delivery and removal line fluidly coupled to the wound site and a peristaltic pump coupled to the combined fluid delivery and removal line. The peristaltic pump is configured to operate in a first direction to deliver instillation fluid to the wound site via the combined fluid delivery and removal line and operate in a second direction opposite the first direction to remove fluid from the wound site via the combined fluid delivery and removal line.

Abstract: Systems, apparatuses, and methods for providing negative-pressure therapy with oxygen therapy are claimed. An apparatus for providing negative pressure therapy with normobaric or hypobaric oxygen therapy may include dressing having a tissue interface and a cover. Additionally, in some embodiments, the apparatus may include a negative-pressure source and an oxygen-concentrating or oxygen-generating source, each of which may be coupled to or configured to be coupled to the tissue interface. The tissue interface can enable fluid transport during negative-pressure therapy cycles, and disbursement of normobaric or hyperbaric oxygen during oxygen therapy cycles. For example, some embodiments of the tissue interface may comprise structures or foams constructed from polyurethane, silicone, or polyvinyl chloride.

Abstract: Various exemplary methods, systems, and devices for joint to pump elevation level user interfaces, autocalibration for joint elevation, and joint pressure estimation are provided. In general, an arthroscopic pump can be configured to estimate fluid pressure at a surgical site, e.g., at a joint, to provide an accurate indication of fluid pressure to users. In an exemplary embodiment, the fluid pressure estimation is based on a fluid pressure measurement at the pump that is adjusted at the pump, e.g., by a processor at the pump that executes instructions stored in a memory at the pump, using one or more control algorithms that adjust for one or more factors, such as pressure loss in tubing and sheath through which fluid flows between the pump and the surgical site and elevation difference between the pump and the surgical site.

Abstract: The present invention discloses a sterile PRP separation kit that has compartmentalized container having a cover that allows for a stage-specific exposure of sterile components of the sterile PRP separation kit housed within stage-specific compartments to a non-sterile environment commensurate with a specific stage of operation of a separation process of PRP. The sterile PRP separation kit includes a PRP tube with segregated portals for injection of blood into the PRP tube, aspiration of PRP from the PRP tube, and for maintaining an interior pressure of the PRP tube at equilibrium with ambient pressure during both injection and aspiration.

Abstract: A method for facilitating milk extraction from a female breast may involve applying a breast contacting portion of a breast pump system to a breast, activating the breast pump system to administer multiple breast pumping cycles, and applying vibrations to the breast during at least a portion of each of the breast pumping cycles, using a vibration device. A vibration generating device may be a component of a breast pump system, an added attachment on a breast pump system or a separate component that works in conjunction with a breast pump system.

Abstract: An introducer set (1) for providing vascular access in a patient's body comprises an Introducer sheath (10) and a dilator (20). The introducer sheath (10) has a tubular body (11) made of flexible material with a distal portion (12), a proximal portion (13) and an inner surface, the proximal portion (13) being configured to be inserted into a patient's vessel to allow a medical device (100) to be inserted through the introducer sheath (10) into the patient's vessel. The tubular body (11) of the introducer sheath has a wall thickness (d) of 0.3 mm or less. The dilator (20) has a body (21) with a proximal portion (23), a distal portion (22) and an outer surface, the dilator (20) being insertable into the introducer sheath (10) such that its proximal portion (23) extends proximally of the introducer sheath (10) when the dilator (20) is inserted in the introducer sheath (10).

Abstract: A connector has a hollow body having a first open end spaced apart from a second open end with a lumen extending between the first and second open ends. At least one channel extends through a sidewall of the body and is recessed from a terminal surface of the first open end. The first open end is sized to be received within an open end of a first tubing. When the first open end is partially inserted into the open end of the first tubing, the at least one channel and a terminal surface of the open end of the first tubing define an opening positioned so that fluid passes through the opening into or out of the lumen. When the first open end is fully inserted into the first tube, the at least one channel is covered by an inner surface of the first tubing to cover the opening.

Abstract: Disclosed herein is an implantable blood pump assembly that includes a housing defining an inlet, an outlet, and a flow path extending from the inlet to the outlet, a rotor positioned within the flow path, a stator positioned within the housing and operable to drive the rotor, and an outflow cannula. The outflow cannula includes a coupler assembly configured for removable mechanical connection to the outlet coupler, and includes a first component of an anti-rotation mechanism and a first component of an axial lock. The housing includes an outlet coupler that includes a second component of the anti-rotation mechanism and a second component of the axial lock. The first and second components of the anti-rotation mechanism are positioned to engage one another prior to the first and second components of the axial lock during insertion of the outflow cannula into the housing outlet.

Abstract: A ventricle assist device comprising a device body with a housing having an inlet and an outlet. A centrifugal pump is disposed in a portion of the housing. The inlet is adapted to allow a flow of blood into the device body housing and an outlet adapted to allow the flow of blood from the device body housing. The flow of blood from the device body housing is primarily directed into the left ventricle, and the inlet and the outlet are positionable in a ventricle.

Abstract: A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Abstract: Percutaneous access sheaths used to provide access to the vasculature and heart for the introduction of percutaneous ventricular assist devices (pVADs), and to remain in place for the duration of pVAD use. The sheaths include actively closeable seals engageable to seal against the drive lines of the pVADs to minimize blood loss during pVAD use.

Abstract: An implantable ventricular assist device comprises an intraventricular stent used for the creation of an artificial chamber inside the ventricle, a balloon-like structure used to drive the change of the artificial chamber between a contractile configuration and a diastolic configuration, a power system used for driving the change of the balloon-like structure between the contractile configuration and the diastolic configuration. There is also a power system and a mechanical design to operate the system working, wherein in the contractile configuration, the balloon-like structure expands and occupies the space of the artificial chamber and drives the blood inside the artificial chamber flow outside the artificial chamber, wherein in the diastolic configuration, the balloon-like structure shrinks and releases the space inside the artificial chamber, and the blood outside the artificial chamber flows back into the artificial chamber. It is easy to reach the goal of cardiac function.

Abstract: A ventricular assist device for use in a human recipient includes a housing within which a series pair of turbine pump segments and at least one set of deswirlers are operative. The series pair of turbine pump segments provides a redundancy in turn enhances the safety factor provided by the ventricular assist device. A controller is powered by a rechargeable battery and is operative to apply appropriate drive signals to the motor drives of the turbine pump segments. The battery may be implanted along with the controller to avoid the need for any external connections to the ventricular assist device. An inductively coupled battery charger for use outside the recipient's body is positioned proximate the battery charger to provide inductively coupled charging for use in driving the ventricular assist device.

Abstract: A system and method for extracting a pVAD device that is implanted with a distal portion in an aorta of the heart and a drive line extending across an inter-atrial septum and out of the body via a superior vessel of the venous vasculature, include a first device that is introduced into a femoral artery and through the descending aorta used to engage a distal part of the pVAD device in the aorta of a patient using an instrument. A second, cutter, device is introduced into the venous vasculature superior to heart, advanced to a position adjacent the inter-atrial septum, and used to cut the pVAD drive line adjacent to the inter-atrial septum. After cutting, a first portion of the pVAD is withdrawn from the body via the venous vasculature, and a second portion is withdrawn from the body via the femoral artery.

Abstract: A filter unit for blood and blood derivatives comprises a body defined by two injection-moulded half-shells of thermoplastic polymer material, there being present between said half-shells a cavity containing a filtering element having two opposing flat faces, an inlet opening and an outlet opening made on the opposing outer surfaces of said body communicating with said cavity. Each of said half-shells comprises a projecting perimetral flange, the flanges of the overlapping half-shells being welded together to form a flange of the body of the filter unit and connect the two half-shells together, the filtering element being wholly contained within the cavity of such body and pressed by shelves projecting into such cavity from each half-shell in the vicinity of its perimetral border and on the two opposing faces, said shelves retaining said filtering element in a stable position within cavity, said thermoplastic polymer material being yielding and semi-rigid.