Patents Issued in April 20, 2021
  • Patent number: 10980990
    Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, controlling delivery of a transdermally-delivered medication, certain embodiments including a flux controller.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: April 20, 2021
    Assignee: N Brereton Medical Technologies, LLC
    Inventor: Neil Brereton Jackson
  • Patent number: 10980991
    Abstract: Disclosed is a microneedle for dental material delivery, the microneedle including a needle body portion; an active ingredient coating portion configured to coat the surface of the needle body portion, and including an active ingredient transferred to the skin tissue within a mouth; and a base portion configured to couple with the needle body portion, and to bend along a skin shape within the mouth, wherein the base portion includes at least one of polyethylene (PE), polypropylene (PP), polytetrafluoroethylene (PTFE), polymethylmethacrylate (PMMA), ethylene vinyl acetate (EVA), polycaprolactone (PCL), polyurethane (PU), polyethylene terephthalate (PET), polyethylene glycol (PEG), polyvinyl alcohol (PVA), poly lactide (PLA), poly lactic-co-glycolic acid (PLGA), and polyglycolide (PGA).
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: April 20, 2021
    Assignee: B&L BIOTECH, INC.
    Inventors: In Whan Lee, Gil Hwan Sung, Seung Ki Baek, In Jeong Choi
  • Patent number: 10980992
    Abstract: Disclosed herein are microneedle devices, kits comprising the microneedle devices, and methods of using the microneedle devices. Specifically, disclosed is a device for transport of a material across a biological barrier of a subject comprising: a plurality of microneedles each having a base end and a tip, with at least one pathway disposed at or between the base end and the tip; a substrate to which the base ends of the microneedles are attached or integrated; and at least one reservoir which is in connection with the base ends of the microneedles array, wherein the reservoir comprises an agent delivery system, wherein the agent delivery system comprises an agent to be transported across the biological barrier, or a means for producing an agent to be transported across the biological barrier, and a means for detecting a physiological signal from the recipient.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 20, 2021
    Assignee: North Carolina State University
    Inventors: Zhen Gu, Yanqi Ye
  • Patent number: 10980993
    Abstract: Disclosed are a microneedle, an apparatus for manufacturing a microneedle including a support part containing a medicinal solution for coating a microneedle, a controller for controlling the temperature of the medicinal solution contained in the support part, and a dryer for drying the medicinal solution coated on the microneedle, and a method of manufacturing the microneedle using the apparatus. According to the configuration, the temperature of the medicinal solution can be adjusted such that a viscosity suitable for coating with the medicinal solution is maintained, whereby the quality of a microneedle coated with the medicinal solution can be improved, and denaturation of active ingredients in the medicinal solution can be prevented, which causes stability increase.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: April 20, 2021
    Assignee: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jung Hwan Park, Hye Rin Jeong, Jee Hyun Park
  • Patent number: 10980994
    Abstract: A dual-sided electrode pad assembly is configured to be placed upon a patient's skin and includes an upper conductive gel layer, a middle conductive layer comprising a highly conductive foil, a highly conductive plastic film or a gel with suspended highly conductive particles, and a lower conductive gel layer. The upper and lower conductive gel layer comprise hydrogel, silicone or hydrocolloid. A removable upper and lower protective liner are disposed on the upper and lower conductive gel layers, wherein the upper and lower protective liners are larger in surface area in comparison to the upper conductive gel layer, the middle highly conductive layer and the lower conductive gel layer. The middle highly conductive layer may be smaller in surface area in comparison to the upper and lower conductive gel layers allowing a perimeter edge of the upper and lower conductive gel layers to be disposed past a perimeter edge of the middle highly conductive layer.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: April 20, 2021
    Inventor: Jens Axelgaard
  • Patent number: 10980995
    Abstract: A bioelectric device includes multiple first reservoirs and multiple second reservoirs joined with a planar substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 20, 2021
    Assignee: Vomaris Innovations, Inc.
    Inventors: Joseph Del Rossi, Troy Paluszcyk
  • Patent number: 10980996
    Abstract: Magnetic orientation-independent magnetically actuated switches may be made by producing an outer cylinder and an actuator cylinder from ferromagnetic sheets and non-ferromagnetic sheets in alternating order. A first ferromagnetic body is attached to an end of the outer cylinder. The actuator cylinder is positioned within a first bore of the outer cylinder, the actuator pin is positioned within a second bore of the actuator cylinder and a third bore of the first ferromagnetic body with a portion of the actuator pin extending beyond the third bore of the first ferromagnetic body. A second ferromagnetic body is attached to the portion of the actuator pin, thus forming the magnetic orientation-independent magnetically operated switch.
    Type: Grant
    Filed: September 22, 2018
    Date of Patent: April 20, 2021
    Assignee: MEDTRONIC, INC.
    Inventors: Richard T. Stone, Spencer Fodness-Bondhus, Walter Doell, John D. Welter, Guillaume Schmit, Niklaus Schneeberger
  • Patent number: 10980997
    Abstract: The present invention relates to a photosensitive implant comprising at least one pixel (10) having at least one diode (12, 12?), a stimulating electrode (14), a counter electrode (18), and a resistor (16), wherein the resistance of the resistor (16) is chosen according to a predetermined relation of resistance, a size of the stimulating electrode (14), and a size of the diode (12, 12?). Further, the present invention concerns a method to provide such an implant.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 20, 2021
    Assignee: PIXIUM VISION SA
    Inventor: Martin Deterre
  • Patent number: 10980998
    Abstract: A method for implanting a wireless neural stimulator device, the method including: inserting a device through on a patient's skin on a posterior side of the patient's neck region, wherein the device includes a proximal end, a distal end, a first opening at the proximal end, a second opening at the distal end, and a lumen extending between the first opening and the second opening; after inserting the device through the patient's skin, advancing the distal end into the epidural space of the patient; inserting the wireless neural stimulator device through the first opening; advancing the wireless neural stimulator from the first opening through the lumen until the wireless neural stimulator exits the second opening and into the patient's epidural space; and advancing the wireless neural stimulator through the epidural space until a target site is reached.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: April 20, 2021
    Assignee: Stimwave Technologies Incorporated
    Inventors: Chad David Andresen, Laura Tyler Perryman
  • Patent number: 10980999
    Abstract: Paddle leads and delivery tools, and associated systems and methods are disclosed. A representative system is for use with a signal delivery paddle that is elongated along a longitudinal axis, and has a paddle length and a first cross-sectional area distribution that includes a first maxima. The system comprises a delivery tool including a proximal handle and a distal connection portion positioned to removably couple to the signal delivery paddle. The paddle and the delivery tool together have a combined second cross-sectional area distribution along the length of the paddle, with a second maxima that is no greater than the first maxima.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: April 20, 2021
    Assignee: Nevro Corp.
    Inventor: Mark Steven Wong
  • Patent number: 10981000
    Abstract: An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: April 20, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, William Dai
  • Patent number: 10981001
    Abstract: A method of pacing a His bundle of a patient heart using a stimulation system including a memory, a pulse generator, a stimulating electrode and at least one sensing electrode includes applying a plurality of impulses through the stimulating electrode to induce a plurality of responses from the patient heart. Each impulse of the plurality of impulses is delivered at a different impulse energy corresponding to a respective output setting of the stimulation system. The response characteristics for each of the plurality of responses are measured and each impulse is assigned a classification based on whether the respective response characteristics indicate capture of one or both of the His bundle and a ventricle of the patient heart. The output setting and classification for each impulse is then stored in the memory.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: April 20, 2021
    Assignee: PACESETTER, INC.
    Inventors: Julie Prillinger, Gene A. Bornzin, Stuart Rosenberg, Aditya Goil, Wenwen Li, Pritika Toutam, Didier Theret, Fujian Qu
  • Patent number: 10981002
    Abstract: An implantable medical device that can include a main body having a tissue-contacting surface comprising a first edge and a second edge, an elongated shaft coupled at or near a first edge of the main body, and an anchoring feature extending from a second end of the elongated shaft. The elongated shaft can have a long axis that extends from a first end of the elongated shaft to a second end of the elongated shaft. The elongated shaft can be oriented such that the second end is positioned above the tissue-contacting surface and an angle between the long axis of the elongated shaft and the tissue-contacting surface is an acute angle. The device can further include an opposing elongated shaft coupled at or near a second edge of the main body.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: April 20, 2021
    Assignee: Verily Life Sciences LLC
    Inventor: Ken Rys
  • Patent number: 10981003
    Abstract: An interferential current therapy kit for treatment of a patient following an orthopedic shoulder surgery includes, within a container for facilitating the distribution and transport of the kit, a first plurality of electrodes, a second plurality of electrodes and an interferential current therapy control unit. The interferential current therapy control unit is configured to supply interferential current electrical impulses, via the electrodes, so as to give rise to at least one first beat impulse acting on the suprascapular nerve of the patient and so as to give rise to the at least one second beat impulse acting on at least one of an axillary nerve and a supraclavicular nerve of the patient.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: April 20, 2021
    Assignee: Feinstein Patents, LLC
    Inventor: Peter A. Feinstein
  • Patent number: 10981004
    Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: April 20, 2021
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
  • Patent number: 10981005
    Abstract: Neurostimulation assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles and/or nerves inside the body and stimulus generators and/or recording instruments mounted on the surface of the skin or carried outside the body. The assembly affords maximum patient mobility and comfort through differentiated components having minimal profiles and connected by way of detachable and adjustable connections.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: April 20, 2021
    Assignee: SPR THERAPEUTICS, INC.
    Inventors: Joseph W. Boggs, II, Robert B. Strother, Kathryn W. Stager, Jonathan L. Sakai, Amorn Wongsarnpigoon, Matthew deBock, Devin Sell, Meredith McGee
  • Patent number: 10981006
    Abstract: The invention relates to a hearing prosthesis having at least one acoustic converter for converting acoustic signals into electrical signals, and comprising an ultrasound device by means of which a multiplicity of focused, pulsed ultrasonic beams can be generated, wherein the ultrasound device can be fixed in the outer ear and/or outside the ear, and wherein, on the basis of electrical signals generated by the acoustic converter, the ultrasonic beams can be focused on to various physically distributed points in a region of the inner ear or in a region of the auditory pathway in the brain, while stimulating nerves.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: April 20, 2021
    Assignee: AUDISENSE GMBH
    Inventor: Vera Herrmann
  • Patent number: 10981007
    Abstract: Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: April 20, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: Yogi Anil Patel, Ravi V. Bellamkonda, Robert Butera, Tarun Saxena
  • Patent number: 10981008
    Abstract: Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include a proximal section including a deflection mechanism for deflecting the proximal section, and a distal holding section extending distally of a distal end of the proximal section and defining a cavity therein for receiving an implantable leadless pacing device. The delivery device may include more than one deflection mechanism for deflecting the proximal section at multiple deflection regions. The delivery device may include more than one tubular member that are translatable relative to one another, and the one or more tubular members may include fixed curve portions. The delivery device may include an atraumatic or bumper tip at the distal end of the holding section.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: April 20, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Brian L. Schmidt, Benjamin J. Haasl, Keith R. Maile, Eric Bielefeld, Dana Sachs, Adwait Kumar, Indaka Gunasekara
  • Patent number: 10981009
    Abstract: A medical device comprises therapy delivery circuitry and processing circuitry. The therapy delivery circuitry is configured to deliver anti-tachycardia pacing (ATP) therapy to a heart of a patient. The ATP therapy includes one or more pulse trains and each of the one or more pulse trains includes a plurality of pacing pulses. The processing circuitry is configured to, for at least one of the plurality of pacing pulses of at least one of the one or more pulse trains, determine at least one latency metric of an evoked response of the heart to the pacing pulse. The processing circuitry is further configured to modify the ATP therapy based on the at least one latency metric.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: April 20, 2021
    Assignee: MEDTRONIC, INC.
    Inventors: Troy E. Jackson, Vincent P. Ganion
  • Patent number: 10981010
    Abstract: Implantable medical systems enter an exposure mode of operation, either manually via a down linked programming instruction or by automatic detection by the implantable system of exposure to a magnetic disturbance. A controller then determines the appropriate exposure mode by considering various pieces of information including the device type including whether the device has defibrillation capability, pre-exposure mode of therapy including which chambers have been paced, and pre-exposure cardiac activity that is either intrinsic or paced rates. Additional considerations may include determining whether a sensed rate during the exposure mode is physiologic or artificially produced by the magnetic disturbance. When the sensed rate is physiologic, then the controller uses the sensed rate to trigger pacing and otherwise uses asynchronous pacing at a fixed rate.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: April 20, 2021
    Assignee: Medtronic, Inc.
    Inventors: Hyun J. Yoon, Wade M. Demmer, Matthew J. Hoffman, Robert A. Betzold, Jonathan D. Edmonson, Michael L. Ellingson, Ben W. Herberg, Juliana E. Pronovici, James D. Reinke, Todd J. Sheldon, Paul R. Solheim
  • Patent number: 10981011
    Abstract: An operating room cable assembly for electrically coupling at least one implantable electrical stimulation lead to a trial stimulator includes an elongated body; a trial stimulator connector disposed at one end of the elongated body; and a lead connector disposed at another end of the elongated body. The lead connector can include one or more buttons that can be pushed to load a lead into the lead connector and released to retain the lead. Alternatively, the lead connector can include a lever that can be operated to load the lead. A further alternative is a slider with a lead engagement element that can be slid between positions allowing loading of a lead and engagement of the lead. Other alternatives include a lead connector with doors that can swing open to allow loading of a lead or a collet/sleeve that can be tightened on the lead.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: April 20, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Joshua Dale Howard, Christopher Shanahan, Geoffrey Abellana Villarta, Peter J. Yoo
  • Patent number: 10981012
    Abstract: According to one aspect of the present invention, there is provided an implantable medical device comprising: an implantable component, comprising an implantable memory module, configured to receive and store recipient-specific operating parameters in the implantable memory module, an external component, comprising an external memory module, configured to communicate with the implantable component to receive the recipient-specific operating parameters, and to configure the external component using the recipient-specific operating parameters, wherein the implantable medical device is configured to transfer the recipient-specific operating parameters upon operationally coupling the implantable component with the external component.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: April 20, 2021
    Assignee: Cochlear Limited
    Inventor: Christopher N. Daly
  • Patent number: 10981013
    Abstract: A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: April 20, 2021
    Assignee: The Cleveland Clinic Foundation
    Inventors: J. Luis Lujan, Ashutosh Chaturvedi, Cameron McIntyre
  • Patent number: 10981014
    Abstract: Dual sequential defibrillation (DSD) systems and methods include the use of a timing device. The timing device can assist a user with DSD administration by providing notifications spaced apart by the inter-shock timing. The user can use these notifications to trigger the administration of defibrillation in a sequential manner. The timing device can also be coupled to two defibrillation devices and can output a signal to each of the defibrillation devices to cause the defibrillation device to administer a defibrillation. The output of the signals by the timing device can be spaced apart by the inter-shock timing. Additionally, the signals can be QRS-like in nature to cause the defibrillation devices to administer a defibrillation when in a sync mode.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: April 20, 2021
    Assignee: The UAB Research Foundation
    Inventors: Tyson G. Taylor, Fred W. Chapman, Gregory Walcott
  • Patent number: 10981015
    Abstract: A method, system, and apparatus for monitoring a magnetic field related to magnetic stimulation may be provided. A system for monitoring a pulsing magnetic field related to magnetic stimulation therapy may include a magnetic stimulation component, a sensor, and a processor. The magnetic stimulation component may be configured to generate the pulsing magnetic field for the magnetic stimulation therapy. The sensor may be configured to generate a signal associated with the pulsing magnetic field. The processor may be configured to estimate a first characteristic associated with a first peak of the signal, estimate a second characteristic associated with a second peak of the signal, and determine a third characteristic of the signal based on the first characteristic and the second characteristic. The processor may be configured to determine whether a failure occurred based on the third characteristic of the signal.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: April 20, 2021
    Assignee: Neuronetics, Inc.
    Inventors: Kenneth Marc Ghiron, Ian Maxwell Shipway, Mark Edward Riehl, Ravi Pillutla
  • Patent number: 10981016
    Abstract: A method of authorizing performance of transcranial magnetic stimulation on a subject using a head mount adapted to bear one or more magnetic assembly devices having unique identifiers. The method comprises connecting the one or more magnetic assembly devices to a control device, each magnetic assembly device being installed at a location on the head mount, receiving, at the control device, the identifiers of the connected magnetic assembly devices. determining whether the installed magnetic assembly devices are authorized for the treatment based on the received identifiers and treatment configuration information in a database, and energizing the connected magnetic assembly devices based on the determination of authorization.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: April 20, 2021
    Assignee: SERAYA MEDICAL SYSTEMS LLC
    Inventors: Leeam Lowin, David Leason
  • Patent number: 10981017
    Abstract: The present invention is directed to a system and method for photoeradication of microorganisms from a target. The target is irradiated with pulsed purple or blue light in which (a) the light pulses have a peak irradiance and a pulse duration sufficient to optically excite a photoactive molecule capable of photoeradication of the microorganisms and (b) the light pulses are separated by an off time sufficient to allow the photoactive molecule to return to a ground state creating an oxidation reaction that produces free radicals which destroy a cellular structure of the microorganisms and thereby photoeradicate all or a portion of the microorganisms. The photoactive molecule may comprise either an endogenous molecule present in the microorganisms or an exogenous molecule applied to the target.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: April 20, 2021
    Assignees: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION, CAREWEAR CORP.
    Inventors: Chukuka S. Enwemeka, John C. Castel
  • Patent number: 10981018
    Abstract: A loading apparatus is usable to embed radioactive seeds into carriers, while limiting exposure of the user to radioactive energy from the radioactive seeds. The loading apparatus facilitates accurate positioning of radioactive seeds within a carrier. The illustrated loaders comprise two components, a base and a lid, although in other embodiments the loaders may be separated into additional components.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: April 20, 2021
    Assignee: GT MEDICAL TECHNOLOGIES, INC.
    Inventors: John Baker, David Brachman
  • Patent number: 10981019
    Abstract: An apparatus includes: one or more input communicatively coupled to one or more medium storing current treatment plan data and a current image of a patient, the one or more input configured to obtain the current treatment plan data and the current image of the patient, wherein the current treatment plan data is for processing by a treatment machine; and a re-planning decision processor configured to determine a re-plan information based at least in part on the current treatment plan data, the current image, and a re-plan triggering model, the re-plan triggering model based on previous treatment plan data and previous image(s), wherein the re-plan information indicates a recommendation regarding treatment re-planning; wherein the re-planning decision processor is configured to output the re-plan information for reducing a burden, or for obviating a need, for a user of the apparatus to manually decide whether the treatment re-planning is desirable or not.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: April 20, 2021
    Inventors: MarĂ­a Isabel Cordero Marcos, Hannu Mikael Laaksonen, Esa Kuusela
  • Patent number: 10981020
    Abstract: A system (12) is proposed for the acceleration of ions to treat Atrial Fibrillation (AF), arteriovenous malformations (AVMS) and focal epileptic lesions; this system (12) includes a pulsed ion source (1), a pre-accelerator (3) and one or more linear accelerators or linacs (5, 6, 7) operating at frequencies above 1 GHz with a repetition rate between 1 Hz and 500 Hz. The particle beam coming out of the complex (12) can vary (i) in intensity, (ii) in deposition depth and (iii) transversally with respect to the central beam direction. The possibility of adjusting in a few milliseconds and in three orthogonal directions, the location of each energy deposition in the body of the patient makes that system of accelerators (12) perfectly suited to irradiation of a beating heart.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 20, 2021
    Assignee: FONDAZIONE PER ADROTERAPIA ONCOLOGICA—TERA
    Inventor: Ugo Amaldi
  • Patent number: 10981021
    Abstract: The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 20, 2021
    Assignees: Carthera, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie (Paris 6)
    Inventors: Alexandre Carpentier, Michael Canney, Alexandre Vignot
  • Patent number: 10981022
    Abstract: A smart respirator includes a main respirator-body including a first open end and a second open end. A diameter of the first open end is smaller than a diameter of the second open end. The smart respirator further includes a front respirator-body arranged at the first open end. The front respirator-body includes a filter sheet arranged inside the front respirator-body and configured to absorb pollutants in air entering the front respirator-body, an air sensor arranged inside the front respirator-body and configured to detect an air index of filtered air filtered by the filter sheet, and a flow sensor arranged inside the front respirator-body and configured to determine a total respiratory amount. The smart respirator also includes a fixation band arranged at the second open end.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: April 20, 2021
    Assignee: Xiaomi Inc.
    Inventors: Tong Zhao, Qun Tao, Huayijun Liu
  • Patent number: 10981023
    Abstract: Embodiments of the present disclosure are directed to a vent monitoring system that includes a first sensor configured to provide feedback indicative of an amount of a substance accumulated in the vent, a second sensor configured to provide feedback indicative of a temperature in the vent, and a control system communicatively coupled to the first sensor and the second sensor, where the control system is configured to generate a notification when the feedback from the first sensor exceeds a first target level and when the feedback from the second sensor exceeds a second target level.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: April 20, 2021
    Assignee: Cardinal IP Holding, LLC
    Inventors: Jill L. Gantos, Peter M. Schmitz
  • Patent number: 10981024
    Abstract: A fire fighting vehicle includes a front axle, a rear axle, an engine, an energy storage device, an electromechanical transmission, a fluid tank configured to store a fluid, a pump configured to provide the fluid from the fluid tank to a fluid outlet, and a power divider positioned between the engine, the pump, and the electromechanical transmission. The power divider includes a first interface coupled to the engine, a second interface coupled to the pump, and a third interface coupled to the electromechanical transmission. The electromechanical transmission is (i) selectively mechanically coupled to the engine by the power divider and (ii) electrically coupled to the energy storage device to facilitate driving at least one of the front axle or the rear axle. The pump is selectively mechanically coupled to the engine by the power divider to facilitate pumping the fluid to the fluid outlet.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: April 20, 2021
    Assignee: Oshkosh Corporation
    Inventors: Jason Shively, Seth Newlin, David Kay, Jack Bermingham, Jon Morrow, David Steinberger
  • Patent number: 10981025
    Abstract: A fire hose cleaning device that includes a washing frame comprising a piping system having one or more spray apertures for discharging a liquid to clean a fire hose. The piping system comprising a base pipe section, a top pipe section disposed in parallel alignment with the base pipe section, and two or more side pipe sections disposed in parallel alignment coupled to the base section and the top section. The washing frame may include a hose adapter. The hose adapter may connect to an open end of a hose to receive a liquid to pass through the washing frame. The washing frame may include one or more hose reception devices coupled to the two or more side pipe sections. The one or more hose reception devices enables a fire hose to be positioned thereon and selectively pass through the washing frame while being sprayed with the liquid.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: April 20, 2021
    Inventor: Joshua Ostler
  • Patent number: 10981026
    Abstract: Embodiments of the present disclosure provide a system for the mounting of obstacles on a climbing wall in a manner which allows the obstacles to take on a number of different positions or orientations without a need to remove the obstacle mounting element from the climbing surface or perform any other significant disassembly. Embodiments of the present disclosure thus provide obstacles that can be repositioned by children during play to instantly create a variety of unique climbing challenge courses.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: April 20, 2021
    Assignee: EVERLAST CLIMBING INDUSTRIES, INC.
    Inventors: Timothy S. Sudeith, Sarah Howard
  • Patent number: 10981027
    Abstract: A hand exercising device with selectively adjustable strength includes a first and second handle pivotably coupled with a spring biased between them, the spring pivotably coupled to the first handle, and a spring positioner coupled to an end of the spring configured to be selectively positioned among a plurality of grooves within the second handle.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: April 20, 2021
    Assignee: YUNGA TART LLC
    Inventor: Kareem Reda
  • Patent number: 10981028
    Abstract: A massage and stretch bench includes: a body with a top plate and a plurality of supports, the top plate including a first positioning hole opening in a vertical direction, and each of the supports being mounted on the bottom surface and provided with an opening; a baseplate inserted along the horizontal direction into the openings of the plurality of supports and having a second positioning hole which is aligned with the first positioning hole and opens in the vertical direction; an upright post inserted along the vertical direction into the first and second positioning holes; and a footrest including a first footrest piece, a second footrest piece and two connecting pieces connected between the first and second footrest pieces so as to define a baseplate-insertion slot which opens in the horizontal direction, and the baseplate is inserted in the baseplate-insertion slot.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: April 20, 2021
    Inventor: Lien-Tsung Li
  • Patent number: 10981029
    Abstract: An exercise apparatus for high intensity interval training includes a pair of elastomer tubing devices being stretchable beyond a resting length and further having a first end forming a hand grip for a user, and an opposing end including an anchor portion to enable releasable attachment to a fixed mount. The elastomer tubing devices are independently affixable to one or more fixed mounts at a first distance between the respective anchor portions along a transverse plane and a second distance above ground level to permit independent or tandem oscillation by the user, wherein the elastomer tubing devices are stretched a predetermined distance beyond the resting length and maintained approximately at the predetermined distance during the oscillation. Mechanical impedance of the elastomer tubing devices is adjustable by the user working against inertia generated during the oscillation.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: April 20, 2021
    Assignee: FMFC LLC
    Inventor: David Parise
  • Patent number: 10981030
    Abstract: A weighted bag having an outer shell and a handle assembly. The outer shell has a plurality of panels and at least one of one of a pair of slots and a first end loop assembly and a second end loop assembly spaced apart from the first end loop assembly coupled to the plurality of panels. The handle assembly has a handle grasping member and a strapping assembly, the strapping assembly extending from the handle grasping member and interfacing with at least one of the pair of slots and the first and second end loop assemblies so as to couple the handle assembly to the outer shell.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: April 20, 2021
    Assignee: Coulter Ventures, LLC.
    Inventors: William Henniger, Laurie Ann Coughlan, Ahmik Jones, Steve Slater
  • Patent number: 10981031
    Abstract: A multifunctional abdominal exercise wheel with a pulling rope includes a first wheel assembly. The first wheel assembly includes a first main support, a first main wheel, a chassis cap and a first sucking disc. An end of the first main support is detachably connected to the first main wheel. The chassis cap is connected to the first main wheel by a bearing. The first sucking disc is connected to the chassis cap by a sucking disc support, and a sucking disc spring is arranged between the sucking disc support and the chassis cap. Another end of the first main support is disposed with a first beam, and the first beam is perpendicularly connected to the first main support. The multifunctional abdominal exercise wheel may have advantages of reasonable structure, multiple functions, high utilization, easy to carry, and being capable of meeting various occasions for fitness at any time.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: April 20, 2021
    Inventor: Zejiao Guo
  • Patent number: 10981032
    Abstract: A mobile exercise platform system having one or more top plates lengthwise oriented in a first longitudinal direction or a second longitudinal direction, and two or more spring bars directly fastened to the top plates and being lengthwise oriented in a transverse direction. A coupling mechanism joins two individual exercise platforms together to increase the modes of exercise that may be performed. Openings in the top plates and support rods fastened to the underside of top plates further increase the versatility of exercise modes.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: April 20, 2021
    Inventors: Erica Randleman, Troy Randleman, Courtney Turner
  • Patent number: 10981033
    Abstract: Methods for instructing a user to perform head and neck exercises with head and neck apparatuses are disclosed. The apparatus may include a member operatively arranged with a valve mechanism with a threshold pressure. The apparatus may further include an acoustic apparatus, membrane, chromogenic material, or moveable element that may be configured to respond when the pressure within the member is greater in magnitude than the threshold pressure. The head and neck exercise apparatus may also include a member operatively arranged with an acoustic apparatus, membrane, chromogenic material, or moveable element that may be configured, without a valve mechanism, to respond when the absolute pressure within the member is greater in magnitude than a threshold absolute pressure.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: April 20, 2021
    Assignee: Berendo Scientific, LLC
    Inventors: Eric J. Kezirian, Jeffrey J. Christian, Gary B. Hulme
  • Patent number: 10981034
    Abstract: A system includes companion device that has movement sensors and a separate wearable device that has core contraction sensors. The companion device can be coupled to moving objects such as exercise equipment. Signals from the companion device and wearable device sensors are transmitted to a processor which analyzes the object movement signals and determines when a qualifying movement is performed which benefits from core contraction. Signals from the core contraction sensors are also transmitted to the processor and are used to determine if the core is contracted during the qualifying movement. If the core is contracted during the qualifying movement, the movement is a protected qualifying movement. However, if the core is not contracted during the qualifying movement the movement is an unprotected qualifying movement. The system can inform the user when unprotected qualifying movements are performed.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: April 20, 2021
    Assignee: Alert Core, Inc.
    Inventor: Gregory Takeo Uehara
  • Patent number: 10981035
    Abstract: A portable lower limb therapy device having a support base and a pulley system. The support base includes a platform member fixably mounted on top of a slider and a heel panel positioned behind the platform member. The heel panel, which sits orthogonally relative to the platform member, is attached to the slider so as to extend from the rear end of the slider. The pulley system defines a closed force transfer system that is integrated with the support base. The pulley system employs a cord member, a support member, a cross member, and two handles and is configured to transfer force applied behind the heel panel to the platform member as well as force applied above a user's foot that is positioned on top of the platform member to the platform member.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: April 20, 2021
    Inventor: Eduardo M Marti
  • Patent number: 10981036
    Abstract: An aquatic training aid includes a paddle member for wearing by a swimmer, a variable diaphragm disposed within the paddle member, the variable diaphragm including a plurality of fitted blades arranged to form an aperture, and a housing peripherally framing the plurality of fitted blades. The variable diaphragm is adjustable to change the aperture from a first expanded position to a second contracted position, and hydrodynamic characteristics of the aquatic training aid when moved through water are affected by the change of the aperture. Controlling the aperture enables the swimmer to adjust the resistance provided by the aquatic training aid when it is moved through water.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: April 20, 2021
    Inventor: Harrison Marsland
  • Patent number: 10981037
    Abstract: Embodiments of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a golf club head may include a body portion having a first interior cavity and a second interior cavity. The first interior cavity may be located in a first transition region between the top portion and the front portion. The second interior cavity may be located within the body portion and in a second transition region between the bottom portion and the front portion. Other examples and embodiments may be described and claimed.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: April 20, 2021
    Assignee: PARSONS XTREME GOLF, LLC
    Inventors: Robert R. Parsons, Bradley D. Schweigert, Michael R. Nicolette
  • Patent number: 10981038
    Abstract: Examples of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a body portion of a golf club head may include a front portion. A face portion may be coupled to the front portion. The face portion may include a central strike portion and a perimeter. A plurality of projections may extend from the face portion to provide a ball striking surface for impacting a golf ball. The plurality of projections may be aligned in one or more directions across the face portion and may progressively increase in size in any direction from the central strike portion to the perimeter of the face portion. Other examples and examples may be described and claimed.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: April 20, 2021
    Assignee: PARSONS XTREME GOLF, LLC
    Inventors: Bradley D. Schweigert, Michael Nicolette
  • Patent number: 10981039
    Abstract: A main body of a golf club head includes a topline portion, a sole portion, a heel portion, a toe portion, a striking face defining a face plane, and a rear surface opposite the striking face. A track member is at least partially nonparallel to the face plane and extends across at least a portion of the rear surface. A weight member is translatable along the track member such that the golf club head has a first center of gravity (CG) defining a first CG depth when the weight member is located in a first position, and a second CG defining a second CG depth when the weight member is located in a second position farther from the striking face than the first position. The second CG depth is greater than the first CG depth, with the CG depth measured normal to the face plane.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: April 20, 2021
    Assignee: Sumitomo Rubber Industries, Ltd.
    Inventors: Patrick Ripp, Christopher Cooper