Abstract: The present invention relates to methods of immunomodulation and treating patients having solid tumors with antibodies that specifically bind CD38.

Abstract: The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention.

Abstract: The disclosure provides for a multimodal cancer therapy comprising chimeric viral/nonviral nanoparticles and anticancer agents and uses thereof to treat a subject with cancer or suspected of having a cancer.

Abstract: Provided are NCC-based materials, as superb barrier materials for preventing oxygen and humidity from penetrating therethrough.

Abstract: The invention provides an improved method of synthesising derivatives of ?-D-glucopyranoside-containing polymers, such as chitin, chitosan, cellulose, amylose, pullulan, curdlan, inulin, guar gum or cyclodextrin. The method includes reacting a polymer of formula (III) with a cyclic imide to form a polymer of formula (I) thereby introducing a nitrogen functionality at the 6-position and providing access to 6-deoxy-6-amino-?-D-glucopyranoside-containing polymers.

Abstract: The present invention relates to a compound represented by Formula 1, a method for preparing the same, and a modified conjugated diene-based polymer having a high modification ratio and including a functional group derived from the compound.

Abstract: A method of operating a dump tank of a polymer production process by transferring all or a portion of a content of a polymerization reactor into the dump tank, wherein the reactor contents comprise solid polymer, and liquid and gaseous non-product components, and removing at least a portion of the liquid and gaseous non-product components from the dump tank by: reducing a pressure of the dump tank, subjecting the solid polymer to a first cleaning stage comprising heating the solid polymer by introducing a first heated treatment gas into the dump tank, and subjecting the solid polymer to a second cleaning stage comprising purging the solid polymer by introducing a second heated treatment gas into the dump tank.

Abstract: To provide a method for producing a multicomponent copolymer with which a multicomponent copolymer having excellent rupture strength can be obtained, and a multicomponent copolymer, a rubber composition and a tire having excellent rupture strength. The method is a method for producing a multicomponent copolymer having a conjugated diene unit, a non-conjugated olefin unit and an aromatic vinyl unit, comprising adding continuously or intermittently continuously a conjugated diene compound into a reactor containing a catalyst and at least one selected from the group consisting of a non-conjugated olefin compound and an aromatic vinyl compound. The multicomponent copolymer is obtained with the production method. The rubber composition comprises the multicomponent copolymer as a rubber component. The tire uses the rubber composition.

Abstract: Catalyst systems and solution olefin polymerization processes using a combination of titanium compounds (e.g. halides) with vanadium compounds (e.g. halides or oxyhalides) with tri-n-octyl aluminum (TNOAL) as a co-catalyst, which provides lower in situ oligomerization of olefins that are incorporated into the homopolymer. This feature provides a higher density homopolymer using TNOAL, which enhances polymer properties such as increased moisture barrier and stiffness. Multi-reactor systems and solution olefin polymerization processes comprising this catalyst system.

Abstract: The present disclosure provides methods for preparing a catalyst system comprising contacting in an aliphatic solvent at least one support material, at least one hydrocarbyl aluminum compound and at least one non-hydrolytic active oxygen-containing compound to form a supported alumoxane (catalyst system precursor) and contacting the supported alumoxane with at least one catalyst compound having a Group 3 through Group 12 metal atom or lanthanide metal atom. The supported alumoxane may be heated prior to contact with the catalyst compound.

Abstract: The present disclosure generally relates to processes to produce alpha-olefin oligomers and poly alpha-olefins. In an embodiment, the present disclosure provides a process to produce a poly alpha-olefin (PAO), the process including: introducing a C6-C32 alpha-olefin and a catalyst system comprising activator and a metallocene compound into a continuous stirred tank reactor or a continuous tubular reactor under reaction conditions, wherein the alpha-olefin is introduced to the reactor at a flow rate of about 100 g/hr or more; and obtaining a product comprising PAO dimer and optional higher oligomers of alpha-olefin, or a combination thereof, the PAO dimer comprising 96 mol % or more of vinylidene, based on total moles of vinylidene, disubstituted vinylene, and trisubstituted vinylene in the product. In at least one embodiment, a process includes functionalizing and/or hydrogenating a PAO product of the present disclosure. In at least one embodiment, a blend includes a PAO product of the present disclosure.

Abstract: In one aspect, a chelating phosphine-phosphonic diamide (PPDA) ligand is described herein for constructing transition metal complexes operable for catalysis of olefin polymerization, including copolymerization of ethylene with polar monomer.

Abstract: A catalyst component for the polymerization of olefins, comprising Ti, Mg, halogen, an electron donor (ID) selected from the group consisting of aliphatic cyclic ethers and alkyl esters of aliphatic monocarboxylic acids and a compound of a metal selected from the group consisting of Zn and Cu, wherein the catalyst component is devoid of Zn—C or Cu—C bonds and the Mg/Ti molar ratio ranges from 4.0 to 50.0.

Abstract: Provided is a tetrafluoroethylene/hexafluoropropylene copolymer which is less likely to form a lump, or is less likely to form a large lump even if a lump is formed, during the formation of an electric wire. The tetrafluoroethylene/hexafluoropropylene copolymer has a melt flow rate measured at 372° C. of 35.0 to 45.0 g/10 minutes and a swell of ?8.0% to 5.0%, the sum of the numbers of —CF2H groups and unstable end groups being 120 or less per 1×106 carbon atoms.

Abstract: The present invention provides a carboxyl group-containing copolymer having a better calcium ion trapping ability and a better carbon black dispersing ability than any conventional carboxyl group-containing copolymers. The present invention relates to a carboxyl group-containing copolymer including a structural unit (a) derived from an unsaturated monocarboxylic acid monomer (A), a structural unit (b) derived from an unsaturated dicarboxylic acid monomer (B), and a structural unit (c) derived from a cationic monomer (C).

Abstract: Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a

Abstract: Disclosed herein is a process for laminating a polar substrate with a film cast from a sulfonated block copolymer having at least one end block A and at least one interior block B wherein each A block contains essentially no sulfonic acid or sulfonate ester functional groups and each B block is a polymer block containing from about 10 to about 100 mol percent sulfonic acid or sulfonate ester functional groups based on the number of monomer units. The film is exposed to water and dried onto a polar or active metal substrate. The laminates do not delaminate in the presence of water, or in a humidity of up to 85%, and at a temperature of at least 60° C. The laminates are used for a variety of applications including energy exchange applications.

Abstract: Novel thermolatent bases and their use as catalysts for the preparation of polyurethanes or epoxy resins are disclosed herein. A process for the preparation of polyurethanes or epoxy resins in the presence of the catalyst is also disclosed.

Abstract: A catalyst composition for making polyurethane foam, the catalyst composition including a compound having a general formula R1R2R3N, wherein each of R1, R2 and R3 are independently selected from the group consisting of: a compound according to formula (I): wherein n=1 to 5; and R4, R5 and R6 are each independently hydrogen, methyl, ethyl and propyl groups; hydrogen, a C1-C6 alkyl group compound, a C1-C6 cycloalkyl group compound, a C1-C6 alkenyl group compound, a C1-C6 alkynyl group compound, a C1-C6 aryl group compound, and a C1-C6 aralkyl group compound, each group being substituted or unsubstituted; wherein at least one of R1, R2 and R3 is a compound according to formula (I). A polyurethane composition and method for forming a polyurethane foam are also disclosed.

Abstract: The present invention provides a polyisocyanate composition and the like that contain a polyisocyanate compound represented by general formula (I), (II), (III) or (IV) (wherein the pluralities of R11, R21, R31 and R41 each independently represent an organic group, at least one of the pluralities of R11, R21, R31 and R41 is a group represented by general formula (V) (wherein each of the plurality of Y1 independently represents a single bond or the like, R51 represents a hydrogen atom or the like, and the wavy line indicates a bonding site) or the like, and in general formula (III), R32 represents a residue in which one hydroxyl group has been removed from a monohydric or polyhydric alcohol).

Abstract: An embodiment of the present disclosure relates to a method for producing an optical component resin having excellent dyeability, an optical component resin, a spectacle lens, and spectacles. A method for producing an optical component resin, including a step of polymerizing a polymerizable composition containing a polyisocyanate component and a polythiol component containing 40 mol % or more of a polythiol compound having two or more sulfide bonds in a molecular structure thereof, in which the content of a hydrolyzable chlorine compound contained in the polyisocyanate component is in a range of 10 ppm by mass or more and 100 ppm by mass or less in the polyisocyanate component, an optical component resin obtained by the producing method, an optical component formed of the optical component resin, a spectacle lens including a lens substrate formed of the optical component resin, and spectacles including the spectacle lens.

Abstract: Disclosed are high strength polyurethane foam compositions and methods of making them. In one aspect, the inventive polyurethane foams include strength enhancing additives comprising one or more polycarbonate polyols derived from the copolymerization of CO2 and one or more epoxides. In one aspect, the inventive methods include the step of substituting a portion of the polyether polyol in the B-side of a foam formulation with one or more polycarbonate polyols derived from the copolymerization of CO2 and one or more epoxides.

Abstract: Disclosed is a moisture curable silane modified terpolymer comprising a polyether segment, a segment of polytetrahydrofuran or polycarbonate, a polysiloxane segment and terminal amino silane groups joined to the terpolymer via urethane linkages and wherein the polyether segment comprises at least 70% by weight based on the total weight of the silane modified terpolymer. Also disclosed is a method of forming moisture curable silane modified terpolymer.

Abstract: The invention relates to a rheology-modifying urethane compound. The compound comprising urethane functions of the invention can be prepared according to a method in several steps which use different compounds comprising isocyanate functions. For the preparation of the urethane compound according to the invention, a monoisocyanate compound, in particular a monoisocyanate compound resulting from the separate condensation of an asymmetric diisocyanate compound with a reactive compound, is reacted with an alkylene glycol compound in the presence of a polyisocyanate compound. The invention also provides coating compositions comprising mineral particles and a urethane compound according to the invention.

Abstract: This invention relates to a process for preparing viscoelastic polyurethane foam in which the isocyanate-reactive component comprises a specific polyol blend, and to viscoelastic polyurethane foam wherein the isocyanate-reactive comprises the specific polyol blend. The polyol blend may be an in situ formed polyol blend.

Abstract: A polymer compound which is useful for producing a light emitting device having excellent luminance life is described. The polymer compound contains a constitutional unit having a residue of a compound represented by the formula (1) and a constitutional unit having no residue of a compound represented by the formula (1): In formula (1), Ring A, Ring B and Ring C represent an aromatic hydrocarbon ring, X represents a boron atom, Y1, Y2 and Y3 represent N-Ry, a sulfur atom or a selenium atom, Ry represents a hydrogen atom, an aryl group, a monovalent heterocyclic group or an alkyl group, and n3 is 0 or 1. When n3 is 0, —Y3— is absent.

Abstract: This invention relates to a biodegradable polyester which is particularly suitable for use in the manufacture of mass-produced articles characterised by excellent mechanical properties, in particular high tensile strength, elongation and tensile modulus, associated with a high barrier property against oxygen and carbon dioxide.

Abstract: The present invention relates to a process for the production of a thermoplastic polyester using a reaction mixture comprising a dicarboxylic acid having a melting temperature of ?200° C. wherein the dicarboxylic acid is introduced to the process in the form of particles having an average particle diameter of ?100 ?m. Such process results in a reduction of the polymerisation time. Furthermore, it allows for the production of thermoplastic polyesters having a desired balance of intrinsic viscosity and carboxylic end group content at a reduced polymerisation time.

Abstract: Provided is a manufacturing method for a high molecular weight aromatic polycarbonate resin that has superior fluidity and for which a good color and a sufficiently high molecular weight can be achieved. A manufacturing method for a high molecular weight aromatic polycarbonate resin includes: a step in which a dialcohol compound expressed by general formula (1) and a catalyst are mixed to obtain a catalyst composition; a step in which the obtained catalyst composition is kept in a molten state, and is mixed with an aromatic polycarbonate prepolymer within ten hours after obtaining the catalyst composition, to obtain a prepolymer mixture; and a high molecular weight achievement step in which the obtained prepolymer mixture is heat-treated under reduced pressure conditions to obtain a high molecular weight aromatic polycarbonate resin.

Abstract: Provided is a photosensitive resin composition containing; (A) a polymer having an acidic functional group or a substituent derived therefrom; (B) a photoreactive compound; (C) a solvent; and (D) a nitrogen-containing aromatic compound represented by the following general formula (1).

Abstract: A polyimide-forming composition includes a particulate polyimide precursor composition having an average particle size of 0.1 to 100 micrometers wherein the polyimide precursor composition comprises a substituted or unsubstituted C4-40 bisanhydride, and a substituted or unsubstituted divalent C1-20 diamine; an aqueous carrier; and a surfactant. A method of manufacturing an article including a polyimide includes the steps of forming a preform comprising the polyimide-forming composition; and heating the preform at a temperature and for a period of time effective to imidize the polyimide precursor composition and form the polyimide. An article prepared by the method, and a layer or coating including a polyimide and a surfactant are also described.

Abstract: Provided are dual cure monomer are of the formula: (I) wherein R* is a (hetero)hydrocarbyl group; X1 is —O—, —S—, —NR3—, —NR3—CO—NR3, —CO—NR3— or NR3—CO—, where R3 is H, C1-C4 alkyl or R1-Epoxy; R1 is a divalent (hetero)hydrocarbyl group; X2 is —O—, —S—, —NR4—, —NR4—CO—NR4—, —CO—NR4—, —NR4—CO— where R4 is H, C1-C4 alkyl or R2—CH?CH2; R2 is a divalent (hetero)hydrocarbyl group; subscripts a and b are at least one, subscripts c and d are at least one, with the proviso that the monomer has at least two epoxy groups and at least two ene groups.

Abstract: Described is a process for producing trifluoromethanesulfonic acid-acidified, end-equilibrated, acetoxy-bearing siloxanes which comprises reacting cyclic siloxanes, in particular comprising D4 and/or D5, and/or cyclic branched siloxanes of the D/T type with acetic anhydride using trifluoromethanesulfonic acid as catalyst and with addition of acetic acid.

Abstract: The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.

Abstract: The present disclosure relates to lignocellulosic materials comprising phosphorylated lignocellulosic fibers having an ionic charge in water of about 4000 to about 7000 mmoles/kg, and processes for the preparation thereof. The process comprises reacting lignocellulosic fibers of a lignocellulosic material with a phosphate ester in the presence of urea. The present disclosure further relates to compositions comprising a phosphate ester and at least one of a defoamer and a viscosity reducer or at least one of a C1-C12 alcohol and an ester of a carboxylic acid.

Abstract: Provided is a production method for a gel composition including steps (1) to (3) mentioned below: step (1) of mixing at room temperature a partial degradation product of the galactose moiety of galactoxyloglucan and an aqueous solvent to obtain a mixture; step (2) of cooling or freezing the mixture obtained in step (1); and step (3) of gelling the mixture cooled or frozen in step (2) by heating to obtain a gel composition that includes the galactose-partial degradation product.

Abstract: A process for manufacturing a cross-linked hyaluronic acid (HA) gel product is comprising the steps of: (a) preparing an aqueous mixture of HA and a cross-linking agent selected from multiepoxides and diepoxides; wherein the HA is dissolved in an aqueous solution containing 1-10% (w/w) inorganic hydroxide; and wherein the dissolved HA constitutes more than 10% (w/w) of the final mixture; and (b) subjecting the aqueous mixture to cross-linking conditions to allow the dissolved HA to react with the cross-linking agent so as to obtain a cross-linked HA gel product.

Abstract: Vulcanizable elastomeric formulation are disclosed. The formulations comprise at least one elastomer; a vulcanizing agent comprising cyclododecasulfur; and a prevulcanization inhibitor, present in an amount, for example, from about 0.01 phr to about 10 phr. The formulations, when vulcanized, provide articles that exhibit improved durability.

Abstract: The present invention aims to provide a method for producing a modified molded article that has favorable appearance, high breaking strength, and excellent abrasion resistance, as well as excellently low permeability to nitrogen gas and hydrochloric acid. The method for producing a modified molded article of the present invention includes molding a fluororesin to provide a molded article and irradiating the molded article with radiation at an irradiation dose of lower than 100 kGy at 50° C. to 200° C. to provide a modified molded article.

Abstract: There is provided a random mat including carbon fibers and a matrix resin, wherein the carbon fibers in the random mat have an average fiber length in a range of 3 mm to 100 mm, a fiber areal weight of the carbon fibers is 25 to 10,000 g/m2, the carbon fibers include a specific carbon fiber bundles having a specific opening degree in a specific amount per the total carbon fibers, and the specific carbon fiber bundles with a thickness of 100 ?m or more are included in a ratio of less than 3% of the number of the total specific carbon fiber bundles.

Abstract: Microporous sheet product and methods of making and using the same. In one embodiment, the microporous sheet product is made by a process that includes melt-extruding a sheet material using an extrusion mixture that includes a thermoplastic polymer, a superabsorbent polymer, and a compatibilizing agent. After extrusion, the compatibilizing agent may be removed from the sheet material. When the sheet product is imbibed with a polar or ion-containing liquid, the superabsorbent polymer swells, causing a reduction in the pore size of the sheet product. The exposure also causes some of the superabsorbent polymer to migrate to the exterior of the microporous sheet product. The microporous sheet product may be used, for example, as a battery separator, as a food packaging material, as a diffusion barrier in the ultrafiltration of colloidal matter, and in disposable garments.

Abstract: A process for reducing water carry-over of a light stabilized polyolefin film, tape or filament which contains component (A) as light stabilizer and which is passed through a water bath during production, characterized in that the polyolefin film, tape or monofilament additionally comprises component (B) as light stabilizer, an example of component (A) is wherein E1 is E2 is and a3 is a number from 2 to 10, and an example of component (B) is

Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.

Abstract: Molded polymer foam articles are described as having a novel a foam structure. The polymer foam articles include a continuous polymer matrix defining a plurality of pneumatoceles therein which is present throughout the entirety of the article, including in the surface region extending 500 microns beneath the surface of the article. The surface region is further characterized as having compressed pneumatoceles. The novel foam structure is achieved even when molding polymer foam articles comprising a thickness of more than 2 cm, a volume of more than 1000 cm3; or both a volume of more than 1000 cm3 and a thickness of more than 2 cm. Methods of making the molded polymer foam articles are also described.

Abstract: The present invention provides a technique for preparing a porous cellulose medium, through the gelation of a solution in which cellulose acetate as a raw material is dissolved, which does not cause a reaction involving the migration of substances. Specifically, a method for producing a porous cellulose medium is provided which includes the steps of gelling a flowable homogeneous composition containing cellulose acetate, an organic solvent, and water through a decrease in temperature; and hydrolyzing the cellulose acetate contained in the resulting gel.

Abstract: A method for recycling polyester from a polyester textile comprises the steps of: providing said polyester textile soaked in a mixture comprising a solvent and a catalyst, providing and maintaining a temperature of said mixture comprising said polyester textile within a range of 80-240° C. during depolymerization of polyester in said polyester textile and wherein, in said step of providing said polyester textile soaked in said mixture, said catalyst of said mixture comprises calcium oxide. A catalyst may be used for depolymerization of polyester in a polyester textile, wherein the catalyst comprises calcium oxide.

Abstract: A silicone-coated filler comprises: a particulate material mainly composed of an inorganic oxide formed by oxidizing a predetermined element; a first silicone structure bonded to a surface of the particulate material by way of a “-‘the predetermined element’-OSi—” structure; and a second silicone structure including a cross-linking structure with a carbon-carbon structure directly bonded to a silicon atom of the first silicone structure, and a polysiloxane structure bonded to the cross-linking structure.

Abstract: The present invention relates to processes for making compatibilized high aspect ratio barrier additives and polymer compositions that comprise compatibilized high aspect ratio barrier additives. The invention also relates to compositions produced by these processes, and articles formed from polymer compositions of this invention. The barrier additives provide passive barriers to gas molecules such as oxygen and carbon dioxide minimizing transit of such molecules through sidewalls of polymer articles containing the barrier additives.

Abstract: A composite comprised of: (i) at least one inverse freezing material, and (ii) an additive in the form of at least one solid particle. Articles made of the composites, and uses of the composites or the articles incorporating same, particularly for reducing incoming shockwaves, are also disclosed.

Abstract: There is provided a rubber composition for additive manufacturing that allows rubber shaped articles to be favorably produced using an additive manufacturing apparatus. The rubber composition for additive manufacturing of the present invention comprises a liquid rubber.