Abstract: An injection device comprises a housing containing a cartridge, a needle holder including an injection needle, and a cap. The cap is removably engaged with the housing. The injection device also comprises a translating mechanism configured such that linear distal movement of the cap causes proximal movement of the needle holder such that the injection needle pierces the cartridge.

Abstract: Plunger sub-assemblies for automatic injectors include a plunger outer having one or more engagement prongs, a plunger inner having one or more engagement slots which correspond with the engagement prongs of the plunger outer, and a retraction biasing member. The retraction biasing member is retained in a first energized state between the plunger outer and plunger inner when the engagement prongs of the plunger outer are releasably engaged with the engagement slots of the plunger inner. The one or more engagement prongs are capable of flexing substantially radially to release from engagement with the engagement slots of the plunger inner to permit the retraction biasing member to expand from the first energized state to a second expanded state. An automatic injector having a plunger sub-assembly includes a housing, an activation mechanism, and a plunger sub-assembly at least partially mounted within a syringe cartridge having a needle assembly.

Abstract: An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

Abstract: A medical puncture needle comprising includes: a rod-shaped body portion; and a blade surface formed at a distal end portion of the rod-shaped body portion. The blade surface includes: a first blade surface portion that is inclined with respect to a central axis of the body portion and extends to a tip, and a second blade surface portion that is formed on a back side of the first blade surface portion. A blade edge extending to the tip is formed by a ridgeline at which the first blade surface portion intersects the second blade surface portion. The second blade surface portion comprises a first plane and a second plane having different angles with respect to a virtual plane including the central axis passing through the tip at an orthogonal cross-section that is orthogonal to the central axis.

Abstract: A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

Abstract: A medication dispenser includes a base seat, a circuitry unit and an outer casing. The base seat includes a mouthpiece. The circuitry unit includes a first circuit board, a battery, and first and second switches disposed on the first circuit board. The outer casing is movable relative to the base seat between a close position where the outer casing covers the mouthpiece and where the first switch is actuated such that electric power is prevented from being supplied from the battery to the first circuit board, and an open position where the outer casing uncovers the mouthpiece and where the second switch is actuated such that electric power is supplied from the battery to the first circuit board.

Abstract: Various embodiments include an inhaler for oral delivery of medication that includes an actuation detector configured to provide an actuation signal in response to release of the medication from the inhaler, and an accelerometer configured to measure an orientation of the inhaler. The inhaler may include a processor, coupled to the actuation detector and the accelerometer, configured with processor-executable instructions to perform operations to determine a quality of use of the inhaler based on the actuation signal provided by the actuation detector and the orientation of the inhaler measured by the accelerometer.

Abstract: The invention relates to a metered dose inhaler (1) for dispensing aerosol doses with an actuation housing (2) and a canister (5) with an aerosol. A triggering unit (8) comprises one single trigger member (21) on a flexible member (22) for activating a switch (19) of a circuit assembly. The flexible member (22) is configured to interact with the canister (5) in such a way that the trigger member (21) is moved in a lateral direction by the canister (5) so that the trigger member (21) engages the switch (19).

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: Embodiments described herein describe a drug delivery device. The device includes a medicament container, a compressed gas container, an outlet, and a double-sided needle located within the housing. When a user presses an actuation button, the compressed air container is moved towards the medicament container and towards a proximal end of the double-sided needle. The double-sided needle pierces both the compressed gas container and the medicament container, opening fluid flow communication between the two containers, and causing medicament to be expelled out of the medicament container.

Abstract: A flow generator includes a blower, a flow generator outlet configured to receive an end of a gas delivery tube, and a controller. The flow generator outlet includes electrical connectors configured to contact corresponding electrical connectors associated with the breathable gas delivery tube when the breathable gas delivery tube is received by the flow generator outlet. The controller includes a tube-type detect circuit and is configured to receive signals from the breathable gas delivery tube by way of the electrical connectors of the flow generator outlet. The tube-type detect circuit is configured so that when the breathable gas delivery tube is received by the flow generator outlet, the tube-type detect circuit determines the type of breathable gas delivery tube based on signals from the electrical connectors of the flow generator outlet that are indicative of a condition of a resistor associated with the breathable gas delivery tube.

Abstract: A flow generator for delivering breathable gas to a patient includes a processor coupled with operation sensors and a user interface. The processor is programmed to generate at least one of time-based or event-based messages relating to at least one of flow generator operation, flow generator service, flow generator use, patient health, peripheral devices and services, patient treatment, and reminders. Time-based messages are generated at predetermined time intervals based on either time of use or elapsed time. The event-based messages are generated based on signals from the operation sensors. The user interface is configured to deliver the messages to at least one of a display, a flow generator service provider, the patient and a physician. By this system, operation of the flow generator is facilitated and enhanced.

Abstract: Systems and methods for estimating a leak flow in a breathing assistance system including a ventilation device connected to a patient are provided. Data of a flow waveform indicating the flow of gas between the ventilation device and the patient is accessed. A specific portion of the flow waveform is identified, and a linear regression of the identified portion of the flow waveform is performed to determine an estimated leak flow in the breathing assistance system.

Abstract: A stabilizer arm for a BVM resuscitator and method of use is disclosed. The stabilizer arm provides the necessary support to the reservoir bag to enable the user to exert downward pressure on the BVM resuscitator while simultaneously squeezing the reservoir bag, and creates force that is focused, directed, and realized at the mask of the assembly. Due to the presence of the stabilizer arm, this pressure pushes the facial mask downward to assist in forming a tight mask to face seal. The stabilizer arm may be internal, external or integrated into the reservoir bag wall of the BVM resuscitator and may be retro-fitted or original equipment manufactured. The external stabilizer arm may be designed to engage the outlet port neck of the BVM resuscitator with an open collar or a closed collar. The internal stabilizer arm may be configured to fit BVM resuscitators having single piece or multiple piece outlet valve design.

Abstract: A system and method for relief of negative lung pressure during acute laryngospasm or upper airway obstruction, providing a non-toxic gas cartridge capable of supplying between 0.5-5 liters of gas during a procedure, a valve adapted to commence and stop gas release, and a trans-cricothyroid cartilage inflation needle for acutely relieving the negative pressure in the chest. The needle may also be used to insert a guidewire to assist in endotracheal tube insertion.

Abstract: Techniques for emergency apneic oxygenation include a cannula having a longitudinal inner passage with an inner diameter. A distal portion has a first outer diameter greater than the inner diameter, and is made of shape memory material shaped to bend in a first direction along the inner passage. A cannula base has a second outer diameter greater than the first outer diameter. A distance from a distal end of the cannula to a proximal end of the distal portion of the cannula is less than a distance from a surface of a throat of a subject to a distal surface of an airway of the subject. The inner passage is configured to pass a catheter connected at a proximal end to an oxygen source. In various embodiments, the cannula is used with a trocar and, optionally, a system base, or supplied in a kit with a catheter.

Abstract: A mask apparatus for a respiratory treatment can permit delivery of breathable gas to a user. In one example, the mask may employ a frame and cushion to form a seal for both mouth and nose. The frame may be adapted for coupling with a respiratory treatment apparatus so as to permit communication of a pressurized gas from the respiratory treatment apparatus. The cushion, which may be foam, may have a substantially under the nose configuration or over the nose configuration. The mask may have a common plenum chamber for both nose and mouth. The cushion may further define a centrally open lip superior region. The cushion may be adapted to couple with the frame directly or to the frame in conjunction with a cushion support clip. Various features of the cushion may further promote sealing and comfort for the under the nose design.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Abstract: In an example, a ventilator includes an outer container containing liquid, an inverted container submerged in the liquid to provide inverted container space between a closed top and an inner container liquid level; gas supply line to supply breathing gas to the inverted container space; and inhalation line having an inlet in the inverted container space to provide breathing gas to patient. The inverted container moves upward from a preset minimum elevation when the inverted container space reaches a hydrostatic delivery pressure and volume of the inverted container space increases. The inverted container stops moving upward and the gas supply line stops supplying when the inverted container reaches a preset maximum elevation. Based on a breath demand signal or preset timing, the inhalation line opens to permit flow of breathing gas to the patient at the hydrostatic delivery pressure, lowering the inverted container due to lost buoyancy resulting in sinkage.

Abstract: A portable control device (10) for regulating a continuous oxygen flow to a user from an oxygen source, comprising: an inlet (11), to which the oxygen source may be fluidly connected; an outlet (12), to which a breathing device may be fluidly connected; a valve arrangement (20) fluidly connected to said inlet and to said outlet, said valve arrangement being adjustable between a maximum flow state corresponding to a maximum continuous flow of oxygen from the inlet to the outlet, and a minimum flow state corresponding to a minimum continuous flow of oxygen; and an actuator (13) movable between a maximum and a minimum position and being mechanically connected to the valve arrangement so that when said actuator is in the maximum position said valve arrangement is in the maximum flow state and when said actuator is in said minimum position said valve arrangement is in said minimum flow state.

Abstract: The present disclosure generally relates to user interfaces for breathing sequences. In some examples, a device displays a configuration user interface that comprises a prompt to select a number of cycles of a breathing sequence, adjusts the number of cycles of the breathing sequence to the selected number of cycles in response to selection, and initiates a breathing phase of the breathing sequence. In some examples, the device displays and fluctuates a progress indicator in accordance with the selected number of cycles. In some examples, a device detects a time associated with a first breathing sequence, generates a prompting criteria based on a predetermined prompting frequency and the detected time, determines if the prompting criteria has been met, displays a prompt to initiate a second breathing sequence, wherein the prompt comprises a first affordance, and displays a second breathing sequence user interface in response to selection of the first affordance.

Abstract: A method for providing a therapeutic benefit to a person is disclosed which includes a processor that executes a first function to determine a physiological parameter from one or more physiological sensors positioned on the person and then the processor executes a second function to determine at least one second physiological parameter from the one or more physiological sensors or an environmental parameter from one or more environmental sensors associated with the location of the person. Next, the processor uses either the first and second physiological parameters or the first physiological parameter and the environmental parameter to determine whether to apply bi-lateral stimulation to the person; activating first and second stimulators positioned bi-laterally on the person to initiate bi-lateral stimulation for a therapeutically effective time period when the processor determines to apply bi-lateral stimulation.

Abstract: System and methods for therapy involving the use of three-dimensional articles of manufacture having printed media at predetermined locations thereon to overcome a therapeutic issue, such as (but not necessarily limited to) fear, phobias, trauma, addiction, grief, depression, feelings of loss, physical pain and diabetic neuropathy. By using the system and methods of the present invention while focusing on emotional and/or physical pain associated with a therapeutic issue, both hemispheres of the brain are activated and random stimulation via place or grid cells and their associated complex circuits occur, which collectively causes or creates new neural connections in the brain of the patient to thereby diminish or even resolve the emotional and/or physical pain associated with the therapeutic issue.

Abstract: A method for managing a guidewire in preparation for a surgical operation, comprising attaching a block of resilient polymer to a coiled tube which contains a guidewire; attaching to the block of resilient polymer a card having printed information concerning the guidewire on a planar surface of the card; removing the guidewire from the coiled tube; removing the block of resilient polymer from the coiled tube while keeping the card having printed information attached to the block of resilient polymer; coiling the guidewire into a flat spiral form; capturing, in a slot formed in the block of resilient polymer, a plurality of portions of the guidewire, which portions are adjacent to and parallel with each other, thereby maintaining the guidewire in the flat spiral form.

Abstract: An apparatus and method for the treatment of intravascular medical conditions is provided. The device comprising a handle assembly, an expandable portion defined by a plurality of struts oriented along a longitudinal axis and a tip member affixed to a distal end of the struts. The struts are moveable between a collapsed and an expanded position. A catheter tube extends from the handle assembly to the expandable portion. An elongate member is disposed within the catheter tube and is in communication with the handle assembly and the tip member.

Abstract: A hub is provided for a sheath, catheter, or other tubular device that includes a tubular body comprising a proximal end, a distal end, and a hub passage extending between the proximal end and the distal end; a valve mounted in the tubular body adjacent the proximal end comprising a proximal surface adjacent the proximal end and a distal surface adjacent an intermediate region of the hub passage; a side port comprising a first end coupled to an outer surface of the tubular body adjacent the intermediate region, a second outer end, and a port passage extending between the second end and the first end and communicating with the intermediate region of the hub passage; and a guide element in the side port adjacent the first end for directing fluid introduced into the second end through the port passage towards the distal surface of the valve.

Abstract: A deflectable catheter with biased deflection characteristics has an elongated catheter body having a micro-injection molded spine that is configured with a center core, outwardly extending opposing struts, and one or more sets of longitudinally-aligned and discrete fins, wherein the struts resist deflection of the spine in a first plane and bias deflection of the spine in a second plane, wherein parameters of the discrete fins define deflection characteristics of the spine in the second plane.

Abstract: A catheter having a catheter shaft that has a more uniform construction throughout a length of the catheter shaft and is able to provide more than one deflection curvature. The catheter shaft includes a flexible outer tubular member, and a less flexible inner tubular member extending through the outer tubular member in a proximal section of the catheter shaft, wherein the inner tubular member is afforded longitudinal movement relative to the outer tubular member. The catheter also includes at least one puller wire extending through the inner tubular member to deflect a distal deflection section of the catheter shaft, wherein the longitudinal movement of the inner tubular member relative to the outer tubular member enables an operator to select and set a deflection curvature of the distal deflection section.

Abstract: A pull wire attachment system for a minimally invasive medical instrument comprises an anchoring element, a steerable tube, and a pull wire assembly. The anchoring element comprises a hollow tube having a first outer diameter. The pull wire assembly comprising a pull wire having a proximal end and a distal end and a securing element coupled to the distal end. A portion of the pull wire is disposed within a groove having an open cross-sectional shape extending along a length of the steerable tube. The securing element includes a second outer diameter sized smaller than the first outer diameter. The securing element is coupled to the anchoring element to prevent proximal translation of the distal end of the pull wire along a longitudinal axis of the medical instrument past the anchoring element. A proximal end of the securing element is disposed distal to a distal end of the steerable tube.

Abstract: A method and system of and for securing a lumen or catheter, after placement in a patient, to prevent unwanted removal or dislodgement of the lumen or catheter caused by patient movement and/or further medical interventions such as cardiopulmonary chest compressions, electrical defibrillation, surgical procedures, and the like. The method and system comprising simple and sterile materials that preclude the use of excessive suturing and ineffective ad-hoc methods with tape and gauze. The catheter is secured by a rubber on plastic frictional force and will resist external forces while preventing the tube structure from bending and subsequent occlusion. The device can be comfortably attached to the patient in all of the anatomical locations typically targeted for large catheter installment. The method of securement is rapid and requires only a single personnel to handle the device and the catheter tube simultaneously.

Abstract: Intravenous access is achieved by introducing a catheter over an access needle which is initially present in the catheter. A tapered dilating element is positioned over the needle and provides a transition between the needle and a larger catheter lumen.

Abstract: A catheter insertion device for inserting a catheter into a body of a patient is disclosed. The catheter insertion device includes a retractable needle for establishing access to a subcutaneous vessel of the patient and a manually extensible guidewire for guiding the initially attached catheter into the vessel. In one embodiment, the catheter insertion device comprises a housing, a hollow needle retractably extending from the housing, a catheter initially disposed on a portion of the needle, a guidewire including a portion initially disposed within the needle, a guidewire advancement feature configured to selectively advance a distal end of the guidewire distally past a distal end of the needle, and a needle retention component configured to selectively enable retraction of the needle into the housing. The needle retention component is configured to be actuated by the guidewire advancement feature. In one embodiment, one-handed operation of the device is possible.

Abstract: There is provided a cervical canal dilator device having a hollow shaft having proximal and distal ends. The shaft is covered on an end portion of the distal end by a slidable protective sleeve. There is at least one inflatable dilating balloon formed on the distal end of the shaft. There is at least one tube extending internally along the shaft and connected to the at least one balloon for inflation thereof, the tube having a connection port on the proximal end of the shaft. A camera is situated at the tip of the distal end of the shaft and a plurality of ejection orifices are formed on the shaft, adjacent to the camera, and anywhere else along it.

Abstract: A guidewire includes a guidewire shaft and an inflatable element arranged at a distal end of the guidewire shaft. At least a portion of the guidewire shaft is formed of metal, and the guidewire shaft includes a lumen that fluidly communicates with an interior of the inflatable element. The inflatable element is operable to transition between a deflated state in which the inflatable element is configured to pass through an isthmus of a Eustachian tube (ET), and an inflated state in which the inflatable element is configured to dilate the ET.

Abstract: A device for auricularly delivering and/or receiving medication which comprises an earcup, a drug cartridge or drug reservoir having active ingredients, and a fluid generator that generates a fluid having active ingredients and delivers the fluid to the earcup. A method for auricularly delivering medication which comprises the steps of receiving medication from a cartridge at a fluid generator, generating fluid comprising the medication, and passing the fluid to an earcup. A system for auricularly delivering medication comprising a headphone comprising at least one earcup, and a replaceable and consumable drug cartridge coupled to the headphone. A method for receiving medication which comprises the steps of placing an earcup on an ear, operating a headphone coupled to the earcup, and receiving fluid generated by a fluid generator, the fluid comprising active ingredients, wherein the fluid generator receives medication from a cartridge comprising active ingredients.

Abstract: Transdermal therapeutic systems are described which have at least one electronic component, as well as methods for producing this type of transdermal therapeutic systems.

Abstract: A tattooing apparatus includes a grip body and a pivot pin. The grip body defines a cavity extending entirely through the grip body in a first direction. The pivot pin is mounted in the cavity perpendicular to the first direction, the pivot pin having an axis of rotation, the pivot pin mounted rotatably around the axis of rotation. A tattoo needle assembly includes a needle bar, a loop, and a plurality of needles. The needle bar has a first end and a second end. The loop is coupled to the first end and defines a first plane. The plurality of needles includes a first row coupled to the second end and defining a second plane, the first plane angled approximately 90 degrees to the second plane. A tattoo needle assembly includes three rows of at least three needles, the needles fastened together to be immovable with respect to each other.

Abstract: A valve for a needleless valve system. The valve includes a body configured to be disposed in the needleless valve system and controlling fluid flow through the needleless valve system and wherein the body is tail-less. The body includes a continuous top surface, and a compression feature configured to control how the body is compressed to allow fluid flow through the needleless valve system.

Abstract: Needleless connectors are described herein. A needleless connector includes a body, a valve element at least partially disposed within the body, and a base. The valve element includes a cylindrical portion having an outwardly extending flange at a distal end. The flange has a bottom surface with an outer area and an inner area. The base includes a rim having a top surface that is in contact with at least a portion of the outer area of the flange of the valve element, the rim defining a recess with a bottom surface distally separated from the top surface of the rim, and at least one support member extending from the rim into the recess so as to contact the inner portion of the bottom surface of the flange.

Abstract: Apparatus and methods are described including a blood pump (24) configured to be placed inside a blood vessel of a in subject, the blood pump including an impeller (28) configured to pump blood by rotating. A support cage (254) is shaped to define a narrow portion (256) that is configured to be disposed around the impeller, and to maintain a separation between a wall of the blood vessel and the impeller, and a radial extension (258) from the narrow portion of the support cage that extends radially outward with respect to the narrow portion of the support cage, the radial extension being configured to substantially maintain a longitudinal axis of the impeller in alignment with a local longitudinal axis of the blood vessel by contacting the wall of the blood vessel. Other applications are also described.

Abstract: Various embodiments of a fluid handling system are disclosed herein. For example, the fluid handling system can include a catheter assembly and a console configured to control the operation of the catheter assembly. A removable interface member can be configured to provide fluid and electrical communication between the catheter assembly and the console. Additionally, a control system is disclosed for controlling operation of the fluid handling system.

Abstract: A blood pump assembly comprising a pump casing, at least a portion of which is disposed around one or more blades coupled to a drive cable, and a motor configured to drive the drive cable and the one or more blades rotationally, wherein the drive cable is configured to undergo axial displacement with respect to the pump casing during rotation.

Abstract: An apparatus (1) far the therapeutic treatment of a user's tissue injury comprising a control unit (2), to which aft applicator (3) is connected adapted to be positioned in proximity of the tissue injury to be treated is described, said control unit (2) being configured to generate at the applicator (3) an electric field adapted to be applied on the tissue injury. The control unit (2) is also configured, to generate an air or oxygen flow which is directed to the applicator (3), and to transform at the applicator (3) the air or oxygen flow into an ozone flow adapted to be diffused and applied on the tissue injury in combination with said electric field.

Abstract: Methods and apparatuses for transdermal electrical stimulation. Described herein are single-use or limited-use TES apparatuses and methods of using them that include an integrated (e.g., flex-circuit) electrode assembly and controller apparatus including a waveform generator and power supply. Also described herein are TES apparatuses including a cord or wire having current control circuitry and configured to connect a mobile computing device (e.g., smartphone or wearable electronics) to an electrode assembly. Finally, also described herein are intermediate apparatuses including a flex-circuit electrode assembly including a waveform generator but receiving power from a cable connected to a mobile computing device.

Abstract: In some embodiments, a clinician programmer device for controlling a deep brain stimulation (DBS) system is adapted to assist a clinician to conduct an electrode screening review for the DBS system including screening of segmented electrodes. The clinician programmer stores software code for conducting a screening review in memory. The software code may comprise: code for providing one or more interface screens for guiding the user of the device through testing of electrode configurations of the implantable stimulation lead, wherein the code for providing applies at least one testing progression for guiding the user of the device through a defined testing order.

Abstract: In one embodiment, a method for fabricating a neurostimulation stimulation lead comprises: providing a plurality of ring components and hypotubes in a mold; placing an annular frame with multiple lumens over distal ends of the plurality of hypotubes to position a portion of each hypotube within a respective lumen of the annular frame; molding the plurality of ring components and the hypotubes to form a stimulation tip component for the stimulation lead, wherein the molding fills interstitial spaces between the plurality of ring components and hypotubes with insulative material; and forming segmented electrodes from the ring components after performing the molding.

Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.

Abstract: An epicardial pacer wire management device can include a spool defining a recessed region that encompasses the spool. The recessed region can receive a portion of a pacer wire. The device can further include a connector attached to the spool, and the connector can be electrically coupled with an exposed tip of the pacer wire. The device can further include an electrical port attached to the spool that can communicate with a pacing control unit. The device may include an electrical communication line electrically coupled between the connector and the electrical port.

Abstract: In one example embodiment, a neuromodulation system for inducing locomotor activity in a mammal, in cooperation with a signal generator and an electrode, delivers a signal with an overlapping high frequency pulse to a mammal.

Abstract: This application describes a miniature implantable neurostimulator system for sciatic nerves and their branches. The implanted miniature neurostimulator is implanted in the leg and stimulates these nerves for the treatment of urinary or bowel incontinence. The miniature implantable neurostimulator has a low duty cycle permitting a small size with medically-acceptable longevity. The system includes a wireless programmer and patient-activated key fob.