Abstract: A method and apparatus are disclosed for assessing a respiratory function from plethysmography data obtainable, for example, from a pulse oximeter. A pulsatile waveform obtained from pleth data is processed to obtain a second waveform extending over multiple respiratory cycles and representing respiration-related variations in a pulse-beat area defined by the pulsatile waveform. The second waveform is analyzed to obtain information indicative of respiratory distress. A respiratory index that provides a good indicator of respiratory distress may be computed based on a magnitude of respiratory peaks in the second waveform. Applications to asthma and sleep apnea are described.

Abstract: A novel method and apparatus for analyzing multi-breath nitrogen washout (MBNW) data from a lung is provided. The novel method includes fitting multi-compartment lung model, having five free parameters, to an exhaled nitrogen concentration profile over the entire duration of expiration for each breath from the lung. The five free parameters include 1) functional residual capacity, 2) dead space volume, 3) the standard deviation of the rate of change of fractional contribution to expired flow from each lung region as a function of lung volume, 4) the intrinsic slope of Phase-Ill due to acinar asymmetry, and 5) the coefficient of variation of regional specific ventilation.

Abstract: An attachment device for a sample collection device for obtaining samples from exhaled respiratory air includes an inlet tube, a dip tube for discharging the respiratory air from the sample collection device, and at least a portion of a spiral path. The portion runs into an outlet opening which is designed to conduct the respiratory air to the sample collection device.

Abstract: Systems and methods use a three-dimensional snapshot of an infant, child, adolescent, or adult where the subject may have bent legs and an unaligned head position, to provide an estimate of human length. The system identifies anatomical features from the digital information and generates a virtual skeleton. The cumulative distances between pseudo-joints of the virtual skeleton provide an estimate of human length. Comparing length estimates from multiple three-dimensional snapshots of the same individual acquired over time provide an indication of growth of the infant, child, or adolescent. Daily estimates of length can detect growth faltering sooner than less frequent estimates of length, which can lead to timely intervention.

Abstract: This disclosure relates to an adjustable tibial sizer for use in knee arthroplasty, the sizer includes a two-part body comprising: a first body portion, a second body portion, and a connection element extending therebetween. Each of the first and second body portions includes a ramp surface configured for simultaneous movement of the first body portion relative to the second body portion in an anterior-posterior direction and a medial-lateral direction, and method of use thereof.

Abstract: A tactile biofeedback system includes is disclosed herein. The tactile biofeedback system can comprise an indicator and a sensor that is configured to be coupled to a user. A computing device can be in communication with the sensor and the indicator. The computing device can be configured to: receive a plurality of inertial measurements from the sensor, determine, based on the plurality of inertial measurements from the sensor, an occurrence of an improper movement, and cause the indicator to notify the user of the improper movement.

Abstract: The invention relates to a method for gait analysis. In this method, data comprising a ground reaction force curve is first obtained from a force measuring device. Then, a determination of a first approximation of the ground reaction force curve performed by at least a first approximation function defined by a set of coefficients. Then, a determination of a second approximation of the ground reaction force curve is performed by a second approximation function formed on the basis of the set of coefficients of the at least one first approximation function. Further, the invention relates to a gait analysis system.

Abstract: A diagnostic system is used for measuring and analyzing startle response of a subject for diagnosis of traumatic brain injuries (TBI) such as concussions. The diagnostic system includes a stimuli delivery circuitry, whereby startle stimuli are delivered to the subject. The diagnostic system comprises at least one sensor circuitry, whereby the startle response of the subject are detected and recorded. The sensor circuitry comprises at least one muscle startle response measuring means, and said diagnostic system comprises a diagnosis circuitry whereby the features of the startle response are extracted and analyzed.

Abstract: An information processing apparatus includes a processor. The processor is configured to output a caution, based on an operation history of a device, the device being worn by a user and emitting sound, and on a judging result regarding whether biological information concerning the user satisfies a condition for hearing loss.

Abstract: Non-invasive methods of detecting hidden hearing loss (cochlear synaptopathy) based on detection of an abnormal ratio of Summating Potential (SP)/Action Potential (AP) (SP/AP) Ratios.

Abstract: The present disclosure relates generally to systems and methods for measuring an analyte in a host. More particularly, the present disclosure relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: Aspects of the present disclosure include a sensor configured to store in memory indications of sensor use information and formulas or indications of formulas for determining the useful life of a sensor from the indications of sensor use information. A monitor connected to the sensor monitors sensor use and stores indications of the use on sensor memory. The monitor and/or sensor compute the useful life of the sensor from the indications of use and the formulas. When the useful life of the sensor is reached, an indication is given to replace the sensor.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: A method for operating a medical device includes activating a processor in the medical device in a low-power operating mode, measuring a first voltage level of the battery, applying at least one discharge pulse to the battery in response to the first voltage level of the battery being greater than a predetermined passivation minimum voltage threshold and less than a predetermined passivation maximum voltage threshold, measuring a second voltage level of the battery after the at least one discharge pulse, and operating the processor in the medical device in an increased-power operating mode to continue operation of the medical device only in response to the second voltage level being greater than or equal to a predetermined operating voltage threshold, the predetermined operating voltage threshold being greater than the predetermined passivation minimum voltage threshold and less than or equal to the predetermined passivation maximum voltage threshold.

Abstract: Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Abstract: The present invention relates to a glucose measurement device which is arranged and operates under the skin of a subject. One embodiment can comprise: a transmitting unit for wirelessly receiving power and transmitting measured biometric-related parameters; a clock recovery unit for recovering a frequency used for the wireless power reception of the communication unit; a direct frequency synthesizer for converting the recovered frequency recovered by the clock recovery unit into a first band frequency; a clock control unit, which divides the recovered frequency so as to input same in an injection locked oscillator as a specific interval frequency; the injection locked oscillator, which receives the first band frequency and the specific interval frequency so as to output a second band frequency; and a measurement unit for measuring subcutaneous biometric-related parameters by using the second band frequency.

Abstract: The present disclosure pertains to a system and method for monitoring lung disease in a patient that is based on information that is derivable from home therapy devices including a ventilation therapy device and an oxygen saturation monitor such as a pulse oximeter. The measured parameters are used to model shunt fraction and a volume of dead space. Based on changes in gas exchange and results of a nitrogen washout test, a change in gas exchange impairment in the patient is observed and is then used to determine progression of a disease, identify a cause of the impairment, and/or to guide treatment of the patient.

Abstract: A method of non-invasive detection of an analyte includes generating a transmit signal having at least two different frequencies each of which is in a radio or microwave frequency range of the electromagnetic spectrum, and transmitting the transmit signal into a target containing at least one analyte of interest using at least one transmit antenna/element. At least one receive antenna/element that is decoupled from the at least one transmit antenna/element is used to detect a response resulting from transmitting the transmit signal by the at least one transmit antenna/element into the target containing the at least one analyte of interest. In one embodiment, the at least one transmit antenna/element can have a first geometry and the at least one receive antenna/element can have a second geometry that is geometrically different from the first geometry.

Abstract: A sensor head for a compact oximeter sensor device includes light sources and light detectors. A compact oximeter sensor device implementation is entirely self-contained, without any need to connect, via wires or wirelessly, to a separate system unit. The sources and detectors are arranged in a circular arrangement having various source-detector pair distances that allow for robust calibration and self-correction in a compact probe. Other source-detector arrangements are also possible.

Abstract: An integrated blood test unit including a blood collection recess, a test component, and a reservoir containing test fluid. The blood collection device moves to a delivery position under control of an actuator, which also releases test fluid from the reservoir onto the test component. Additional features are a window over the test outcome indicator, a blood delivery channel that only operates if the sample size is large enough, and a geometry for a lancet and actuator that is adapted for a self test situation.

Abstract: Disclosed herein is a syringe-integrated platelet extraction device including: a housing having a longitudinal inner space for receiving collected blood, open at a top thereof, and formed at a bottom thereof with an orifice to which a syringe needle is coupled; a cap coupled to the orifice of the housing; a collector press-fitted into the housing from above the housing; a connector detachably coupled to an upper portion of the collector; and a plunger detachably coupled to the connector.

Abstract: A device includes a pre-sample reservoir, an actuator mechanism, and a diverter. The pre-sample reservoir can be fluidically coupled to a delivery member to receive and isolate a predetermined volume of bodily-fluid withdrawn from a patient. The actuator mechanism is operably coupled to the pre-sample reservoir such that, when actuated, a negative pressure is formed in the pre-sample reservoir that urges the bodily-fluid to flow into the pre-sample reservoir. The diverter can selectively control fluid flow between the delivery member and the pre-sample reservoir. The diverter includes a flow control mechanism that defines a first fluid flow path and a second fluid flow path. The diverter is movable between a first configuration in which the bodily-fluid flows through the first fluid flow path to the pre-sample reservoir, and a second configuration in which the bodily-fluid flows through the second fluid flow path to a sample reservoir coupled to the diverter.

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

Abstract: A catheter extension set may include a distal end, which may include a luer adapter configured to couple to a catheter adapter. The catheter extension may also include a proximal end, which may include a blood collection device. The blood collection device may include a needle configured to receive a blood collection container. The catheter extension may include one or more extension tubes extending between the distal end and the proximal end. The catheter extension set may increase flow resistance, which may reduce a risk of hemolysis when there is a high-pressure differential within the catheter extension set. After a pressure differential within the catheter extension set is lowered, the catheter extension set may decrease flow resistance, which may facilitate more rapid blood collection.

Abstract: A method of deception detection based upon ocular information of a subject provides a video camera configured to record a close-up view of a subject's eye. A cognitive state model is configured to determine a high to a low cognitive load experienced by the subject. An emotional state model is configured to determine a high to a low state of arousal experienced by the subject. After asking a question, the ocular information is processed to identify changes in ocular signals of the subject. The cognitive state and emotional state models are evaluated based solely on the changes in ocular signals where a probability of the subject being either truthful or deceptive is estimated for a binary output.

Abstract: A method of assessing operational risk based upon ocular information of a subject includes providing a video camera recording a close-up view of a subject's eye. The ocular information is processed to identify changes in ocular signals of the subject through the use of convolutional neural networks. Changes in ocular signals are evaluated from the convolutional neural networks by a machine learning algorithm. A duty fitness result is determined for the subject where the duty fitness result is either fit for duty, unfit for duty or more information needed. The results can then be displayed to the subject and/or to a supervisor.

Abstract: A method of discovering relationships between iris physiology and cognitive states and/or emotional states of a subject includes providing a computing device and a video camera to record a close-up view of the subject's eye. A first light is held to the lower eyelid skin and a second light a distance away illuminating the stroma of the eye. The first and second light are electronically synced together and configured to flash alternatively. The user engages in a plurality of tasks while recording ocular information which is processed to identify correlations between the responses in the iris musculature and the distortions in the stroma through the use optimized algorithms. One can then identifying at least one predictive distortion is identified in the stroma capturable solely with a visible-spectrum camera correlating to a predicted responses in the iris musculature.

Abstract: Provided are an apparatus and method for testing personality based on animal symbols. The method includes outputting images of a plurality of preset animals on a screen, receiving an input for selecting a first animal group of a first number from a user, receiving an input for selecting a second animal group of a second number from the user, generating a characteristic pattern by combining characteristics of animals selected in the first animal group and the second animal group, determining a user personality type based on the generated characteristic pattern and a personality type table, and outputting the determined user personality type.

Abstract: Systems and methods for are disclosed for determining whether to output an indication of a urinary tract infection (UTI) in a patient, based on sensor data indicative of one or more common symptoms of UTIs, including, but not limited to, nocturia, fatigue or tremors; fever or chills; agitation or restlessness; lower back pain; painful urination; and presyncope or syncope.

Abstract: Embodiments disclosed herein directed to systems, apparatuses, and methods for the suppression of artifacts in non-invasive electromagnetic recordings. A data set, such as an electroencephalography (EEG) or magnetoencephalography (MEG) data set may be recorded by a number of sensors. The data set may include contributions from a signal of interest and from artifacts. The contribution of artifacts may be suppressed by splitting the data set into projected data and residual data based on a spatial model of the signal of interest. The projected data may contain contributions from the signal of interest and artifacts, while the residual data may primarily contain contributions from artifacts. The projected and residual data may be compared to remove or reduce the contribution of artifacts from the projected data.

Abstract: An interference signal measuring facility is in a differential voltage measuring system with a signal measuring circuit for measuring bioelectric signals with a number of useful signal paths, each with a sensor electrode. In an embodiment, the interference signal measuring facility has an additional sensor lead for each sensor electrode each of which is electrically connected to a ground connection of a supply lead of a sensor electrode; and a measuring amplifier circuit, for each sensor electrode connected to the additional sensor lead via an electrical resistor, configured to detect a change in electric potential occurring on the sensor lead and to determine an electrode reference interference signal therefrom. Also described is an interference signal compensation facility; a differential voltage measuring system; and a method for generation an interference-reduced biological measurement signal are described.

Abstract: An electrocardiogram measuring device, including a first machine body, a second machine body, a third machine body, a circuit module, and two connecting members, is provided. The first machine body, the second machine body, and the third machine body respectively has an exposed first electrode, an exposed second electrode, and an exposed third electrode. The circuit module is disposed in one of the three machine bodies. The first electrode, the second electrode, and the third electrode are connected to the circuit module via an electrical signal. One of the connecting members is located between and connected to the first machine body and the second machine body. The other connecting member is located between and connected to the first machine body and the third machine body. A non-zero included angle is formed between the two connecting members. Relative positions of the three machine bodies are fixed through the two connecting members.

Abstract: An electrocardiogram lead package that contains low-cost printed constructs and the associated method of manufacture. The electrocardiogram lead package contains a first and second printed construct. The constructs include electrodes, lead hubs, and printed wire leads on a flexible substrate. The electrodes contain printed contact heads. The lead hubs contain printed contact pads. The printed wire leads contains printed conductive pathways. On the flexible substrate, the electrodes of the two constructs are linearly aligned and interposed. When separated from the electrocardiogram lead package, the first and second printed constructs provide all the electrodes and leads needed to perform an electrocardiogram. After one use, the printed constructs are discarded.

Abstract: A wearable electrocardiography monitoring ensemble is provided. At least one internal structure is formed within a garment and defined by two horizontal bands across a front surface of the garment. An electrode assembly is positioned within the internal structure and includes at least one electrode to sense cardiac electric signals. An electrical connection is connected on one end to one of the electrodes and interfaced on an other end to a monitor recorder that records the cardiac electric signals. The internal structure exerts against a top surface of the electrode assembly a compressive force that presses the electrode assembly against a wearer's skin.

Abstract: A method for assessing peripheral nerve stimulation (PNS) for a coil geometry includes retrieving a PNS Huygens' P-matrix for a body model. The PNS Huygens' P-matrix is defined on a Huygens' surface enclosing the body model. The method further includes generating a coil specific PNS P-matrix for the coil geometry based on at least the PNS Huygens' P-matrix for the body model, determining at least one PNS threshold for the coil geometry based on the coil specific PNS P-matrix, and storing the at least one PNS threshold in a storage device.

Abstract: A method and medical device for determining a cardiac episode that includes sensing a cardiac signal, identifying the signal sensed during a predetermined time interval as one of a cardiac event, a non-cardiac event, and an unclassified event, determining a number of identified cardiac events, determining a number of identified unclassified events, and determining whether the cardiac episode is occuring in response to the number of identified cardiac events being greater than a cardiac event count threshold and the number of identified unclassified events being less than an unclassified event count threshold.

Abstract: A sensor of an implantable medical device senses electrical activity of the brain. A data analyzer of the device monitors an electrographic signal corresponding to the electrical activity of the sensed brain signal, and processes the brain signal to obtain a measure of phase-amplitude coupling. For a selected portion of the electrographic signal, the data analyzer detects first features and second features of the electrographic signal. The first features represent oscillations in a low frequency range, while the second features represent oscillations in a frequency range higher than the low frequency range. For example, the low frequency range may correspond to theta frequency and the higher frequency range may correspond to gamma frequency. The data analyzer determines a measure of phase-amplitude coupling between oscillations in the low frequency range and oscillations in the higher frequency range based on occurrences of second features which coincide with first features.

Abstract: Systems and methods capture light reflected back from a patient's fundus and compares the resulting images to prior images, to determine if the patient is experiencing intraocular inflammation or atrophy.

Abstract: The present disclosure relates to a method for providing biomarker for early detection of Alzheimer's Disease (AD), and particularly to a method that is able to enhance the accuracy of predicting AD from Mild Cognitive Impairment (MCI) patients using the Hippocampus magnetic resonance imaging (MRI) scans and Mini-Mental State Examination (MMSE) data. The providing MRI images containing the anatomical structure of Hippocampus biomarker and MMSE data as a training data set; training a processor using the training data set, and the training comprising acts of receiving MRI images and MMSE data as a testing data set from a target; and classifying the test data by the trained processor to include aggregating predictions.

Abstract: Cognitive decline detection system includes obtainment unit and determination unit. Obtainment unit obtains the amount of movement during a sleep period and the amount of movement during a non-sleep period of a user for each day, the non-sleep period being the period other than the sleep period. Determination unit determines that the cognitive function of the user is lower during a determination period than during a comparison period set before the determination period when the frequency of days when a movement amount ratio falls below a predetermined ratio among days constituting the determination period is higher than that among days constituting the comparison period, the movement amount ratio representing the ratio of the amount of movement during the non- sleep period to the amount of movement during the sleep period.

Abstract: The present disclosure describes a fast-scanning optical-resolution photoacoustic (fsOR-PAE) endoscope for imaging vasculature within tissues in vivo that includes an ultrasonic transducer and a scanning mirror within a lumen of an elongate casing. The scanning mirror is configured to direct the laser pulses from the pulsed laser source to a focal spot outside the casing in a scanning pattern via an imaging window formed in the casing. The scanning mirror is further configured to direct a plurality of photoacoustic signals from the focal spot to the ultrasonic transducer via the imaging window.

Abstract: Embodiments relate to an apparatus for evaluating skin tightening and a method for evaluating skin tightening by using the same, the apparatus comprising: a suction device for suctioning skin by a predetermined pressure for a predetermined time; a height measurement unit for measuring the height of the skin, which is changed by the suctioning; and a skin tightening evaluation unit for evaluating the degree of skin tightening on the basis of the measured height.

Abstract: A medical or dental device for determining a bone's quality by cutting a thread into the bone with a rotating threaded element comprises a control unit having a measurement circuit configured: (i) to determine values of the motor current via a first electrical contact device with which the motor drive is supplied for rotational drive of the threaded element that can be connected to the motor drive, the current values being a measure of the bone's quality; (ii) to monitor and/or to determine the penetration depth of the threaded element into the bone, and (iii) to generate measurement signals which show the relationship between the penetration depth and the determined current values or parameters derived therefrom, and to transmit these signals to a display unit, which displays the relationship between the determined current values or parameters derived therefrom, in particular the bone's quality, and the penetration depth.

Abstract: An oral care implement including a handle and an oral care refill head. The handle has a gripping portion, an engagement component coupled to a distal end of the gripping portion, and a stem. The engagement component includes a plate portion and a first engagement feature. The stem extends through an opening in the engagement component and protrudes from the plate portion. The oral care refill head includes an oral care treatment portion and a sleeve portion. The sleeve portion has an inner surface that defines a sleeve cavity having a cavity axis and a second engagement feature. When the oral care refill head is detachably coupled to the handle, the first and second engagement features mate with one another to at least one of: (1) position the oral care refill head and the handle in an operational alignment; and (2) lock the oral care refill head to the handle.

Abstract: Described herein are methods and systems for monitoring acoustical activity from the abdominal region to guide the optimal timing of food ingestion. According to one embodiment of the method, the rate of intestinal digestion events, as well as the change in the rate across specific time periods, is analyzed to guide ingestion behavior in a way that improves health. The result of guidance may be to reduce weight in people who are obese, to improve performance in athletes seeking to balance energy availability and energy expenditure, or to increase caloric intake in people who are undernourished. The method can be applied using a smartphone application to provide contextually appropriate and specific user guidance about whether, when, and how much to eat in a manner that aligns with the physiologic patterns of intestinal activity.

Abstract: A method for generating sleep apnea information for a portion of body sensor data. The method of generating sleep apnea information is made dependent upon a determined presence or absence of arrhythmia within the portion of body sensor data. A first sleep apnea detection methodology is used in response to an absence of arrhythmia being detected within the portion of body sensor data.

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of th4e analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

Abstract: A system for making clinical decisions.

Abstract: The present invention relates to circadian rhythm management. In order to improve circadian rhythm management, an apparatus is provided that uses an alternative exercise-based concept and personalized approach for managing or controlling personal circadian rhythm and optimizing sleep onset.

Abstract: A wearable electronic device and method are disclosed, including: at least one sensor including a plurality of electrodes, at least one processor operatively connected with the at least one sensor, and a memory operatively connected with the at least one processor. The processor implements the method, including detecting coupling of the wearable electronic device with an external accessory contacting a body of a user, and based on detecting the coupling with the external accessory, measuring a biometric signal using a voltage received from at least two electrodes from among a plurality of measurement electrodes included in the external accessory.