Abstract: The present invention provides methods and devices for isolating cells from a subject by circulating the subject's body fluid over an affinity moeity coupled matrix to isolate cells from a subject either ex vivo or in vivo. One aspect of the invention is directed to connecting a subject to a system capable of circulating the subject's body fluid through an affinity moiety coupled matrix, such that the affinity moiety coupled matrix is capable of binding to and extracting target cells from the body fluid, and then eluting the target cells from the affinity moiety. Another aspect of the invention is directed to the apparatus for isolating cells from a subject, comprising a blood circulation system with an arterial side blood circuit for extracting blood and flowing the blood over an affinity moiety coupled matrix that binds to and extracts target cells and a venous side blood circuit for returning the blood to the patient.

Abstract: Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.

Abstract: A pressure-measuring system, including a tube system having at least first and second pressure measuring devices, each including a pressure transducer membrane and a measuring chamber. A first flow regulation device with a perfusion tube section is positioned between the first pressure measuring device and a supply of fluid, and has a first tube clamp that acts on a tube section by squeezing. The system further includes at least one non-perfusion regulation device.

Abstract: A nerve monitoring system facilitates monitoring an integrity of a nerve.

Abstract: A biomagnetic measurement method, a biomagnetic measuring device, and a biomagnetic measuring system. The method and the biomagnetic measuring device includes obtaining first measurement data output from a magnetic field detector upon giving a stimulus to a subject in a first state where a site of interest of the subject is made close to the magnetic field detector, and obtaining second measurement data output from the magnetic field detector upon giving a stimulus to the subject in a second state where a site to which the stimulus is given and a position of the site to which the stimulus is given are equivalent to a site to which the stimulus is given and a position of the site to which the stimulus is given in the first state, respectively, and the site of interest of the subject is separated from the magnetic field detector with reference to the first state.

Abstract: The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Abstract: An embodiment of the invention may include a method, computer program product and computer system for neural activity interpretation. The method, computer program product and computer system may include a computing device that presents a first user with a stimulus and monitors and maps the neural activity of the first user. The computing device may receive the first user's verbal reaction to the stimulus and map the linguistic data of the first user's verbal reaction to form a high dimensional vector based on the relationships of the mapped neural activity and the mapped verbal reaction of the first user. The computing device may associate the high dimensional vector with the stimulus presented resulting in a thoughts model. The computing device may receive a second user's neural activity and compare that second user's neural activity to the thoughts model to identify the neural activity in the second user.

Abstract: In one embodiment, an ECG monitoring system includes two or more electrodes configured to record cardiac potentials from a patient, at least one processor, and a rapid acquisition module executable on the at least one processor to: determine that an impedance of each electrode is less than an impedance threshold; record initial ECG lead data based on the cardiac potentials; determine that a noise level in each ECG lead of the initial ECG data is less than a noise threshold; start a recording timer once the noise level is below the noise threshold; record an ECG dataset while the noise level is maintained below the noise threshold until the recording timer reaches a predetermined test duration; store the ECG dataset and provide a completion alert.

Abstract: Electrocardiography (ECG) signals contain important markers for Coronary Heart Disease (CHD). State of the art systems and methods rely on clinically available multi-lead ECG for CHD classification which is not cost effective. Moreover the state of the art methods are applied on digital ECG time series data only. Also, discriminative HRV markers are not often present in short ECG recordings necessitating long hours of ECG data to analyze. In accordance with the present disclosure, systems and methods described hereinafter extract ECG time series from ECG images obtained from commercially available low-cost single lead ECG devices through a combination of image and signal processing steps including Histogram analysis, Morphological operation-thinning, Extraction of lines, Extraction of Reference Pulse, Extraction of ECG and interpolating missing data.

Abstract: A wearable device and respiration sensing module are provided. The wearable device includes a first respiration sensing module and a second respiration sensing module. The first respiration sensing module is configured to sensing respiration of a user to obtain a first respiration information. The second respiration sensing module is configured to sensing respiration of the user to obtain a second respiration information. The second respiration sensing module includes a substrate, a first electrode, a second electrode and a stretchable conductive element. The first electrode and the second electrode are disposed on a first surface of the substrate. The stretchable conductive element is physically and electrically connected between the first electrode and the second electrode. The respiration of the user is judged according to the first respiration information and the second respiration information.

Abstract: An electrocardiography patch is provided. A backing forms an elongated strip with a mid-section connecting two ends of the backing. The mid-section is narrower than the two ends of the backing. An electrocardiographic electrode is provided on each end of the backing to capture electrocardiographic signals. A flexible circuit includes a pair of circuit traces electrically coupled to the electrocardiographic electrodes. A wireless transceiver communicates at least a portion of the electrocardiographic signals.

Abstract: Devices, systems and methods for the treatment of chronic inflammatory disorders that include an implantable microstimulator and an external charger/controller wherein the microstimulator is configured to operate using closed-loop feedback. The feedback for the microstimulator can be electrical activity of the vagus nerve and/or heart sensed by the microstimulator. The feedback can be used to modulate the stimulation duration, intensity, frequency, on-time and off-time.

Abstract: A method and system for filtering a detected ECG signal are disclosed. In a first aspect, the method comprises filtering the detected ECG signal using a plurality of digital filters. The method includes adaptively selecting one of the plurality of digital filters to maintain a minimum signal-to-noise ratio (SNR). In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.

Abstract: Atrial fibrillation information can be determined from ventricular information or a ventricular location, such as using ventricular rate variability. An ambulatory medical device can receive indications of pairs of first and second ventricular rate changes of three temporally adjacent ventricular heart beats. A first count of instances of the pairs meeting a combined rate change magnitude characteristic and a second count of instances of the pairs in which both of the first and second ventricular rate changes are negative can be used to provide atrial fibrillation information.

Abstract: An electrocardiogram (ECG) processor is disclosed. The ECG processor includes ECG sampling circuitry configured in a first mode to acquire a continuous ECG sample set from an ECG signal by digitally sampling the ECG signal at a Nyquist rate for a first predetermined number of heartbeats and in a second mode to acquire a non-continuous ECG sample set from the ECG signal for a second predetermined number of heartbeats by digitally sampling active regions of the ECG signal that contain a PQRST complex and not from silent regions between adjacent PQRST complexes. The ECG processor also includes processing circuitry configured to determine from the continuous ECG sample set relative locations of the active regions and provide the relative locations of the active regions to the ECG sampling circuitry for sampling the ECG signal in the second mode.

Abstract: Methods, systems, and techniques for providing neurofeedback and for training brain wave function are provided. Example embodiments provide a Brain Training Feedback System (“BTFS”), which enables participants involved in brain training activities to learn to evoke/increase or suppress/inhibit certain brain wave activity based upon the desired task at hand. In one embodiment, the BTFS provides a brain/computer interaction feedback loop which monitors and measures EEG signals (brain activity) received from participant and provides feedback to participant. The BTFS may use an FFT based system or machine learning engines to deconstruct and classify brain wave signals. The machine learning based BTFS enable optimized feedback and rewards, adaptive feedback, and an ability to trigger interventions to assist in desired brain transitions.

Abstract: Provided is a method for mapping a neural area involved in speech processing, including applying a plurality of recording electrodes to a surface of a cortex of a human subject, presenting a plurality of auditory stimuli to the subject wherein some of the plurality of stimuli are speech sounds and others of the plurality of auditory stimuli are non-speech sounds, recording brain activity during the presenting of the plurality of auditory stimuli, and identifying one or more brain areas wherein activity changes more after presentation of speech sounds than it does after presentation of non-speech sounds, wherein the human subject does not speak during the presenting and the recording. Also provided is a method for mapping a neural area involved in speech production wherein the human subject does not speak during presenting speech stimuli and recording neural activity.

Abstract: A non-contact blood circulation detection system and method thereof is provided. The non-contact blood circulation detection system comprises a thermal image acquisition module, a non-contact blood oxygen detection device and an information processing module. The thermal image acquisition module faces to a biological skin and generates a thermal image corresponding to the biological skin when being activated; the non-contact blood oxygen detection device faces to a biological skin and generates a blood oxygen image corresponding to the biological skin when being activated, and the information processing module is in information connection with the thermal image acquisition module and the non-contact blood oxygen detection device so as to receive the thermal image and the blood oxygen image, and generates a blood circulation image on the basis of the thermal image and the blood oxygen image, wherein the blood circulation image is a two-dimensional image.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. The sensor can include bi-axial or tri-axial accelerometers, as well as resistive, inductive, capacitive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

Abstract: The invention relates to a system for characterising the sleep of an individual, the characterisation system comprising: a measuring device for measuring a brain activity signal representing the brain waves; a central electronic unit for identifying, in a range of frequencies of between 9 and 16 Hz, a smaller range of sleep spindles of the individual, the smaller range of sleep spindles comprising the brain wave frequencies of the sleeping individual, having an amplitude higher than 15 ?V and a duration of between 0.5 seconds and 2 seconds, and comparing, with a threshold, at least one parameter of the brain activity signal of the awake individual in the range of frequencies corresponding to the smaller range of sleep spindles; and a communication interface connected to the central unit and used to emit a warning signal perceptible by the individual when the parameter of the brain activity signal in the range of frequencies corresponding to the smaller range of sleep spindles exceeds the threshold.

Abstract: Disclosed is an information processing method executed by a computer. The information processing method includes identifying a sleep onset time and an awakening time based on time series data relating to an activity status of a user; calculating a first midpoint at which an interval between the sleep onset time and the awakening time is evenly divided into two; and outputting information indicating a time at the calculated first midpoint.

Abstract: A monitor recorder optimized for electrocardiography and respiratory data acquisition and processing is provided.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: This disclosure relates generally to a system and method for analyzing live activity on the conductive fabrics with intelligent touch. The system comprises a plurality of modules and these modules are in sync with the processor of the system to take action based on a plurality of instructions of the memory. Further, the system comprises fabrics, which are of conductive in nature, are used as a conductive touch pads for inputs to the system. The input data from touch pads are analyzed to determine pattern of actions. These patterns are associated with the IoT devices and the system uses them to trigger at least one action on the at least one IoT device based on a predefined training data set.

Abstract: Embodiments described herein relate to apparatus and techniques for aligning and coupling a sensor device to a wearable patch. A shoe apparatus is coupled to the wearable patch. The sensor device is coupled to the shoe apparatus via one or more connectors of the shoe apparatus. As the sensor device is inserted into the shoe apparatus, features of the shoe apparatus enable alignment of the sensor device with the shoe apparatus and the one or more connectors.

Abstract: A wearable electronic device with a function of detecting a wearing state, comprising: at least one electrode; a capacitance calculating circuit, coupled to the electrode, configured to calculate a capacitance variation generated by at least one of the electrode; and a wearing state determining circuit, coupled to the capacitance calculating circuit, configured to determine the wearing state according to the capacitance variation. By this way, the wearing state can be auto detected and the wearable electronic device can be correspondingly control according to the wearing state.

Abstract: A system and method for monitoring respiration of a user, comprising: a respiration sensing module including a sensor configured to detect a set of respiration signals of the user based upon movement resulting from the user's respiration; a supplementary sensing module comprising an accelerometer and configured to detect a set of supplemental signals from the user; an electronics subsystem comprising a power module configured to power the system and a signal processing module configured to condition the set of respiration signals and the set of supplemental signals; a housing configured to facilitate coupling of the respiration sensing module and the supplementary sensing module to the user; and a data link coupled to the electronics subsystem through the housing and configured to transmit data generated from the set of respiration signals and the set of supplemental signals, thereby facilitating monitoring of the user's respiration.

Abstract: The present invention relates to a wearable device for healthcare and method for using the device. More specifically, the wearable device is worn on a finger for measuring the health data of the user, selected from one or more of heart rate, blood oxygen saturation, heart rate variability. Based on the measured data, the sleep quality can be monitored and recorded. Disorders such as obstructive sleep apnea (OSA), can be detected. The wearable device may include an optical sensor coupled with or embedded in a main body including a visible light emitter, an IR light emitter and a light detector being arranged along a longitudinal direction of the finger. During operation of the wearable device, the heart rate is monitored based on a detected light signal. When the heart rate is higher than an adaptive threshold, both heart rate and blood oxygen saturation are monitored.

Abstract: Intravascular imaging catheters are provided that include a distal sheath portion having a lumen that is configured to optionally receive a guidewire or an imaging assembly. The distal sheath portion may be configured to have dimensions such that when a guidewire is inserted through the lumen and extends through a distal exit port, the distal sheath portion may be employed as a microcatheter. External tissue may be imaged at a location at or near the distal end of the catheter, enabling, for example, the controlled imaging of a total occlusion, and the positioning of the distal end (and guidewire) within a true lumen associated with a total occlusion. A structural stop may be provided at or near the distal end of the distal sheath portion to prohibit extension of the imaging assembly out of the distal exit port, while permitting the extension of the guidewire through the distal exit port.

Abstract: An electronic device is disclosed. The electronic device includes a case and a battery cover forming an appearance of the electronic device and a printed circuit board mounted inside the case and provided with electronic elements. A measurement sensor is mounted on at least a portion of the printed circuit board. One surface of a recess of the printed circuit board, on which the measurement sensor is mounted, is formed at a different height from other portion of the printed circuit board in a thickness direction of the electronic device. The recess, on which the measurement sensor is mounted, is thinner than the other portion and is spaced apart from the other portion, and thus the electronic device can more accurately measure a body temperature of a user.

Abstract: In a method and medical imaging apparatus for determining a feature characterizing intentional breath-holding by an examination object for acquiring medical raw data with breath-holding algorithm, an algorithm, the algorithm being designed to allocate at least one feature characterizing intentional breath-holding to at least one physiological property. The algorithm includes or accesses trained artificial neural network. A physiological property of the examination object is detected during free breathing of the examination object. The feature characterizing intentional breath-holding by the examination object is determined by the computer, by executing the algorithm with the detected physiological property of the examination object, as an input to the algorithm.

Abstract: A blood flow disorder detection device includes: a sensor sheet including a flexible substrate and a plurality of sensors provided on the flexible substrate; and an analyzer that analyzes outputs of the plurality of sensors. The plurality of sensors measure different types of blood flow information of a living tissue, the blood flow information being obtained by attaching the sensor sheet to the living tissue. The analyzer detects a blood flow disorder in the living tissue by analyzing the different types of blood flow information from the plurality of sensors.

Abstract: A health status detecting system includes a first acquisition device configured to collect a plurality of images of a finger of a user; a second acquisition device configured to obtain an electrocardiogram of the user; and a processor configured to process the plurality of images to obtain a pulse wave of the user and configured to obtain a blood pressure of the user based on the pulse wave and the electrocardiogram of the user.

Abstract: The present disclosure pertains to a system for facilitating configuration modifications for a patient interface computer system based on an equivalent effort parameter. In some embodiments, the system obtains (i) one or more first measurements associated with a first subject, the first subject having a clinical coefficient, (ii) one or more second measurements associated with a second subject. The system determines (i) a first effort parameter based on the one or more first measurements, (ii) a second effort parameter based on the one or more second measurements, and (iii) an equivalent effort factor for the first subject based on the one or more first measurements, the one or more second measurements, and the clinical coefficient. The system causes a configuration of the patient interface computer system to be modified based on the equivalent effort factor.

Abstract: Systems and methods are disclosed that facilitate visualizing how a user will appear in response to adhering to a health and fitness program. In an aspect, a system includes a reception component configured to receive information corresponding to a user's physical appearance and physical health, an analysis component configured to determine or infer one or more changes to the user's physical appearance based on predicted performance of a health and fitness program by the user and the user's physical health, and a visualization component is configured to generate a visual representation of the user based on the information and the one or more changes to the user's physical appearance.

Abstract: Systems and methods are provided for evaluating an alarm condition for a monitored patient in a population of one or more patients. One or more physiological parameters pertaining to the patient, or physiological variables, are used to form a time series describing the patient status. A dimension parameter such as a time series roughness statistic or a fractal dimension is used to estimate a dimension decision statistic over time. The dimension decision statistic is used as a measure of physiological condition. The dimension decision statistic may be compared to a threshold to determine a region of operation for the dimension of the physiological variable. The dimension decision statistic is used in an embodiment in combination with the underlying raw physiological variable value to reduce the rate of false alarms, to increase the frequency of missed detections, and to aid diagnostic decision making and to aid the formation of a crisis action plan.

Abstract: High definition, color images, animations, and videos for diagnostic and personal imaging applications are described along with methods, devices and systems for creating the images, as well as applications for using the images, animations and videos.

Abstract: A patient support system includes independently adjustable end columns supporting a centrally hinged, jointed or breaking patient support structure. At least one column includes a powered rotation assembly. The patient support includes at least two sections. A coordinated drive system provides for both upwardly and downwardly breaking or jointed orientations of the two sections in various inclined and tilted positions. Cable, cantilevered and pull-rod systems are included.

Abstract: Intraoral three-dimensional (3D) tomosynthesis imaging systems, methods, and non-transitory computer readable media are used to generate one or more two-dimensional (2D) x-ray projection images and to reconstruct, using a computing platform, the one or more 2D x-ray projection images into one or more 3D images of an object, such as teeth of a patient, which can then be displayed on a monitor in order to enhance diagnostic accuracy of dental disease. The intraoral 3D tomosynthesis imaging system can include a wall-mountable control unit connected to one end of an articulating arm, the other end of which is connected to an x-ray source, which is configured to generate x-ray radiation that is acquired by an x-ray detector held at a desired position by an x-ray detector holder that is removably coupled to a collimator at an emission region of the x-ray source.

Abstract: Systems and method for performing X-ray computed tomography (CT) that can improve spectral separation and decrease motion artifacts without increasing radiation dose are provided. The systems and method can be used with either a kVp-switching source or a single-kVp source. When used with a kVp-switching source, an absorption grating and a filter grating can be disposed between the X-ray source and the sample to be imaged. Relative motion of the filter and absorption gratings can by synchronized to the kVp switching frequency of the X-ray source. When used with a single-kVp source, a combination of absorption and filter gratings can be used and can be driven in an oscillation movement that is optimized for a single-kVp X-ray source. With a single-kVp source, the absorption grating can also be omitted and the filter grating can remain stationary.

Abstract: A system is provided that includes at least one detector and a processing unit. The at least one detector is configured to acquire imaging information. The processing unit is operably coupled to the at least one detector, and is configured to acquire the imaging information from the at least one detector. The processing unit is configured to acquire patient scanning information for an imaging operation, determine a target activity based on the patient scanning information, determine a target time for performing the imaging operation corresponding to the target activity, perform the imaging operation at the target time to acquire targeted imaging information; and reconstruct an image using the targeted imaging information.

Abstract: The invention relates to a computed tomography radiological apparatus including: an X-ray source (22) capable of emitting an X-ray beam longitudinally towards an object, a device (32) for simultaneously splitting the beam into a plurality of beam portions each having a defined propagation direction relative to the longitudinal direction of emission of said X-ray beam, several sensors (20a-c) intended to receive beam portions which irradiated the object and are arranged transversely side by side relative to the longitudinal direction of the beam, the assembly consisting of X-ray source-splitting device-sensors being capable of turning about an axis of rotation (24) and of adopting different geometric orientations that are angularly shifted with respect to one another in order to, on the one hand, irradiate the object along each one of said geometric orientations of said assembly with the plurality of X-ray beam portions, and, on the other hand, to receive along each one of these geometric orientations the p

Abstract: A mobile radiography apparatus with a portable transport frame has a sectioned vertical column mounted on the transport frame. The sectioned vertical column defines a vertical axis and has a vertically fixed base section and an upper section that is movable with respect to the base section along the vertical axis. Cable and pulley systems are coupled to the vertical column sections and/or the transport frame. A boom is coupled to the movable section for positioning an x-ray source attached to the boom.

Abstract: The present invention relates to a device for displaying image information, the device comprising: a detection unit (10), which is configured to identify a plurality of admissible display orientations of multiple data sets; a restriction unit (20), which is configured to restrict the plurality of admissible display orientations of at least one of the multiple data sets to a set of admissible display orientations in common for all the multiple data sets; and/or to restrict a plurality of admissible scrolling directions of at least one of the multiple data sets to a set of admissible scrolling directions that are normal to the restricted admissible display orientations; and a display unit (30), which is configured to display the multiple data sets using the set of the restricted display orientations and/or the set of restricted scrolling directions.

Abstract: A method of imaging to permit calculation of left:right striatum uptake ratios is provided, and the degree of asymmetry used to assist in the diagnosis of neurological diseases. Also provided are a method of diagnosis, method of patient selection, and method of therapy monitoring using the imaging method, and software tools for use in the method.

Abstract: This X-ray fluoroscopic imaging apparatus is provided with an image processing unit that corrects magnification of a plurality of X-ray images based on first height information and generates a first long image by stitching the images together. The image processing unit is configured to generate a second long image in which the magnification of the plurality of X-ray images is corrected based on second height information upon acceptance of an input of second height information after generating the first long image.

Abstract: A first sequence of cardiac image frames are received by a first neural network of the neural network system. The first neural network outputs a first set of feature values. The first set of feature values includes a plurality of data subsets, each corresponding to a respective image frame and relating to spatial features of the respective image frame. The first set of feature values are received at a second neural network of the neural network system. The second neural network outputs a second set of feature values relating to temporal features of the spatial features. Based on the second set of feature values, a cardiac phase value relating to a cardiac phase associated with a first image frame is determined.

Abstract: An embodiment of a method includes providing a first result list indicating a plurality of first anatomic structures and indicating, for each respective first anatomic structure of the plurality of first anatomic structures, a corresponding first severity indicator; providing a second result list indicating, for each respective second anatomic structure of the plurality of the second anatomic structures, a corresponding second severity indicator; providing a relationship matrix indicating a level of interrelatedness between the first anatomic structures and the second anatomic structures; and generating, based on the first result list provided, on the second result list and on the relationship matrix provided, a concordance visualization indicating a respective level of concordance between at least one of the first anatomic structures and the corresponding first severity indicator, and indicating a respective level of concordance between at least one of the second anatomic structures and the corresponding sec

Abstract: In one embodiment, A medical diagnostic imaging apparatus includes: a scanner that images a first site of an object and generates medical image data, wherein the scanner acquires biological information from a sensor that detects the biological information at a second site of the object that is different to the first site, and images the first site based on the biological information that changes according to a movement at the second site of the object.

Abstract: A method and apparatus is disclosed, which significantly improves image quality. Specifically, the method disclosed utilizes structures within an image with a known or calculated value, such as a phantom or presumed homogeneous structure, such as an air mass outside of the patient. The method then performs segmentation of the imaging dataset and subsequent measurement of the structure with a known value. The difference between the known value and the measured value is used as a correction factor, which is then applied to the remainder of the dataset where values are not known. This can improve image quality by helping to generate extremely similar gray scale maps over multiple examinations and eliminate artifacts.