Abstract: The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their use in such methods. PET imaging methods and methods of diagnosis employing such radiolabelling agents form a further aspect of the invention.

Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity of a group of disorders and abnormalities associated with alpha-synuclein (?-synuclein, A-synuclein, aSynuclein, a-synuclein, A-syn, ?-syn, aSyn, SNCA, Non-amyloid beta component of Alzheimer's disease (AD) amyloid plaques, Non-A4 component of amyloid precursor, NACP) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease (PD). The instant compounds are particularly useful in the diagnosis of the preclinical state of such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament.

Abstract: The present invention relates to an air shower gate and, more specifically, to an air shower gate installed at an indoor/outdoor entrance/exit so as to remove microdust, hazardous materials, and odor from people entering/exiting same, and configured to monitor the quality of indoor/outdoor air such that, through air purification or ventilation, a comfortable and clean indoor environment can be maintained and managed. An air shower gate according to the present invention has the following advantages: Dust and the like gathered on clothes during outdoor activities can be removed, and indoor and outdoor spaces are separated by an air curtain, thereby enabling the user to move in/out conveniently without having to open/close a door. Inflow of dust into the indoor space is prevented by the air curtain, and indoor air is filtered to perform an air purifying function.

Abstract: A mobile computing device monitors sanitization of an object by electro-optical (EO) radiation emitted by a sanitizer device. The mobile computing device determines the cumulative exposure based on a position and/or orientation of the sanitizer device relative to the object. The mobile computing device captures images of the object, and augments the image with graphical elements indicating a cumulative exposure of respective portions of the object by the EO radiation. The augmented images may be presented within a graphical user interface presented on a display of the mobile computing device.

Abstract: Various implementations of the invention are directed toward a sanitizing door handle and/or components of such sanitizing door handle. Some implementations of the invention are directed toward a manual sanitizing door handle while some implementations of the invention are directed toward an auto-sanitizing door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto an exterior surface of the sanitizing door handle in connection with an operation of the door handle to sanitize the door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto a user's hand(s) in connection with an operation of the door handle to sanitize the user's hand(s).

Abstract: A system for treating an enclosed area having an access door with an atomized fluid may include a fogging device including a housing and an atomizing generator carried by the housing including an atomizing nozzle in fluid communication with a fluid reservoir, and a compressor coupled to the atomizing nozzle. The fogging device may further include a processor, and the system may further include a controller configured to selectively actuate an electronic door lock actuator to lock and unlock the access door. The processor may be configured to communicate with the controller to initiate an automated treatment cycle during which the compressor dispenses atomized fluid into the enclosed area via the atomizing nozzle while the access door is locked, and to not dispense atomized fluid into the enclosed area while the access door is unlocked.

Abstract: Systems and methods for securely delivering, transferring ownership, storing, accessing and receiving or returning an item from another are disclosed herein. In one embodiment, a system and method are provided to securely receive a variety of different sizes and types of packages at one or more locations, including but not limited to on or adjacent a recipient's property. In another embodiment, the system and method allow a user to receive, store and/or return an item without exposing the item to loss, damage, spoilage or other events that would impair the value of the items. Methods of utilizing the systems described herein are also disclosed.

Abstract: Aspects of the disclosure include an attachment for providing a scent to a container. In some aspects, a scent delivery system includes a bottle including a collar and a ledge structure each extending circumferentially outward; a scent ring loaded with a volatile chemical agent to emanate and generate a scent and including an interior protruding structure projecting from an interior wall of the ring, the scent ring configured to fasten around the neck of the bottle based on contact between the interior protruding structure and the ledge structure of the bottle; and a cap reversibly attachable to the bottle and including an interior rim structure that circumferentially projects from the interior of the cap, where the cap is structured to enclose the scent ring in a compartment formed between the collar and the interior rim structure when the cap is securely fastened to the bottle and trap the scent.

Abstract: The present disclosure provides a composite dressing comprising a combination of porous matrix and fabric substrate wherein at least one of said porous matrix and fabric substrate is composed biomaterial(s) and wherein the fabric substrate is at least partially embedded in the porous matrix. Further, the disclosure provides a method for preparation of said composite dressing, wherein said method enables production of the composite dressing having cohesive bonding between porous matrix and fabric support without use of any adhesive, stitching or chemical crosslinking agent between the two layers. The composite dressing exhibits high peel strength in both dry and wet conditions and has applications such as hemostatic dressings for deep cavity wounds, puncture wounds, post-partum hemorrhage and internal hemostatic agents.

Abstract: The disclosure provides a medical composite material including 55-65 parts by weight of a polyethylene terephthalate (PET) fiber, 8-12 parts by weight of a carbon ion filament fiber, 18-23 parts by weight of a polyurethane (PU) film, and 5-15 parts by weight of an excipient.

Abstract: A chromogenic absorbent material for detecting a detectable substance in a water-containing medium, such as animal urine, is provided. The detectable substance may be indicative of a disease or condition, and the water-containing medium may be an excretion, blood, plasma, an aqueous solution or a solid impregnated with an aqueous solution. The chromogenic absorbent material may include a trigger agent, a chromogenic indicator convertible into a chromogenically active substance in the presence of the trigger agent and the detectable substance, and an absorptive material which is porous, for absorbing the water-containing medium. The absorptive material may include a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material. The trigger agent, the chromogenic indicator and the detectable substance are preferably unreactive to the absorptive material.

Abstract: The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.

Abstract: Compositions-of-matter comprising a matrix made of at least one elastic layer and at least one viscoelastic layer and an adhesive promoter and/or adhesive layer, are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

Abstract: A biocompatible metal implant is provided with a treated surface subject to abrasive mechanical treatment, acid treatment, and sodium treatment, where the biocampatible metal implant treated surface has a macroporosity in the form of cells having dimensions of the order of 50 ?m to 250 ?m, the cells having pores of from 1 ?m to 50 ?m, and pores with a size of less than a micrometer, homogeneously over the whole of the treated surface, the treated surface having a surface roughness Ra of greater than or equal to 1.90 ?m.

Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

Abstract: Formulations of cellulose nanofiber useful for osteoinduction are provided.

Abstract: A method for producing a bundle of biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle.

Abstract: Compositions including a decellularized and enzymatically solubilized amnionic membrane (AM) hydrogel, methods for making such compositions, and methods for their use are disclosed.

Abstract: A method of treating volumetric muscle loss (VML) injury involving the administration of a hydrogel that is free of biological cells and growth factors is described. The hydrogel can comprise a crosslinked hydrogel matrix further comprising heparin wherein the hydrogel can be administered to a subject in precursor form and allowed to crosslink in situ in a muscle injury site or administered in a lyophilized powder, sheet or disc form. The presently disclosed subject matter further describes lyophilized hydrogel matrix materials, such as sheets, wafers and powders, that can be used to treat VML injury.

Abstract: Various embodiments discussed in the present document relate to an implant assembly. The implant assembly includes a porous metal coating. The implant assembly further includes a biocompatible implant material. A polymeric binder layer is disposed between the porous metal coating and the biocompatible implant material.

Abstract: A microporous biocomposite that is suitable for surgical implantation in an avascular environment is provided. The microporous biocomposite includes (1) a polymer scaffold having a thickness less than about 100 ?m and nodal structures that extend to at least one surface of the polymer scaffold and (2) a hydrophilic coating on the polymer scaffold. In some embodiments, the porous scaffold is a microporous biomaterial with nodal structures that extend from a first surface to a second surface of the microporous biomaterial. The hydrophilic coating may be a node and fibril coating. The microporous biocomposite allows for the integration and sustained viability of epithelial cells on the surface thereof as well as tissue integration and the internal colonization of the biomaterial with other cell types, such as keratocytes and fibroblasts. In at least one embodiment, the microporous biocomposite may be incorporated into an artificial corneal implant or in other avascular mesoplants.

Abstract: Polymer devices are disclosed with microstructured surfaces that modify their absorption pathway. Polymers which generally degrade in water by fracturing into high surface energy fragments, are modified to degrade in vivo without the formation of sharp fragments. Devices are disclosed that possess improved handling characteristics and degrade in an aqueous environment in a uniform and continuous way that favors the formation of soluble monomers rather than solid particulate. Absorbable medical implants with the disclosed surface modifications are more biocompatible, with reduced foreign body response, and dissolution into metabolizable molecular species.

Abstract: Infusion sets for subcutaneous drug delivery are described herein. The infusion set integrates a bijel-templated material (BTM) into a cannula such that a portion of the BTM protrudes from the cannula tip into the host tissue. The BTM is a porous, polymeric sponge having a co-continuous architecture with consistent curvature throughout non-constricting, interpenetrating channels, which is critical in mitigation of the deleterious host tissue response, vascularization, and flow redistribution in the implant.

Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate formed from a first material and a second material. At least one of the first and second materials includes a hemostatic agent. Kits, systems and methods are disclosed.

Abstract: An implant, such as an endovascular implant, has degradable main body that defines a lumen. A degradable coating including at least one degradable polymer substantially completely encloses the main body on its luminal and abluminal sides. An antiproliferative active substance is upon the degradable coating only on the abluminal side of the main body.

Abstract: An apparatus including a hollow body, an inlet fluidly coupled to the hollow body, a piston slidably engaged within the hollow body, and a filter module arranged within the hollow body between the inlet and piston. The piston and hollow body cooperatively generate a negative pressure, relative to ambient, within the hollow body during distal piston translation from a first position to a second position, thereby drawing a fluid, such as blood, through the filter module into the hollow body. The piston and hollow body cooperatively generate a positive pressure, relative to ambient, within the hollow body during piston translation from the second position to the first position to egress the filtered fluid from the hollow body. The filter module may include a filter housing, a filter medium disposed within the housing, and a body valve configured to seal an open distal face of the filter housing.

Abstract: An electric breast pump 1 includes a breast placement part 12 at which a breast part including a breast and a nipple of a subject is placed and suction-pressure generating units 10 and 50 that generate a suction pressure in the breast placement part. The suction-pressure generating unit generates a suction cycle including a plurality of different suction pressures. The suction cycle includes basic suction, increased suction with an increased suction pressure, and reduced suction with a reduced suction pressure. A suction pressure difference between a suction pressure increasing in the increased suction and a suction pressure reducing in the reduced suction is an equal pressure and is a pressure difference at a borderline at which a user perceives a change of a suction pressure. In the suction cycle, the basic suction, the increased suction, and the reduced suction are each repeated multiple times consecutively at an equal suction pressure.

Abstract: An improved breast pump flange assembly, flexible membrane and method of use are disclosed. In some embodiments, the breast pump flange assembly includes a flanged housing having an interior chamber extending therethrough. The flanged housing including an upper receiving portion having a first diameter, a substantially tubular middle portion having a second diameter, and a substantially tubular lower connecting portion having a third diameter. In some embodiments, the breast pump flange assembly further includes a flexible membrane having an opening extending therethrough. The flexible membrane having one or more support pad positioned at least partially around the opening of the tubular middle portion of the flanged housing. The support pad configured to simulate the sensation of a baby's mouth on a breast, causing the breast to be massaged by intermittent suction action produced by a breast pump.

Abstract: The present invention relates to a smart breast pump with a massage course generating function including: a close contact unit attached to the user's breast; an expression unit for repeatedly producing expression pressures patterned by the user's input to control an internal pressure of the close contact unit; and a connection unit for connecting the close contact unit to the expression unit to have a relation with the production of the expression pressures in the close contact unit and the discharge of breast milk expressed, wherein through an input part mounted on the expression unit, any one of an expression mode for expressing the breast milk and a massage mode for massaging the breast is selected.

Abstract: The present invention relates to a sorbent manifold and related systems and methods having a plurality of passageways fluidly connectable to one or more valves and one or more sensors and components for use in a sorbent dialysis system. The sorbent manifold can control the one or more valves to direct fluid to either pass through a sorbent cartridge or bypass the sorbent cartridge based on measurements obtained from sensors.

Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

Abstract: The present invention concerns an extracorporeal circuit for removing CO2 from blood comprising a blood withdrawal line for withdrawing blood from the patient, a filtration unit for producing plasma water and a line for returning the blood to the patient, defining a main circuit; the extracorporeal circuit further comprises a decarbonating group comprising a secondary circuit for the recirculation of plasma water, means for removing a fraction of said plasma water, a CO2 exchanger, a cationic resin charged with H+ ions set upstream of the CO2 exchanger and adapted to generate acid plasma water, means for the infusion of the acid plasma water upstream of the CO2 exchanger and means for the infusion of ions in a solution downstream of the CO2 exchanger.

Abstract: A method for applying focused pressure to a target vessel to restrict blood steal from the hand associated with the fistula. The target vein is treated with intermittent pressure multiple times a day to force blood into the hand by restricting blood flow through the fistula. The treatment is produced through a vein compression device having an inflatable bladder.

Abstract: Provided is a molded filter used for a flexible disposable bag which is produced so as to be capable of sucking and storing, for example, bodily secretions of a patient and being disposed when a fixed storage amount is reached, wherein a laminate of at least two elements of a powdered hydrophilic swelling agent and a charged nonwoven fabric, and more preferably, a laminate of three elements with a hydrophobic porous film added thereto, is used as a filter base material and the charged nonwoven fabric is arranged downstream of the powdered hydrophilic swelling agent in a direction of flow of expiratory air inside the body. Thus, the molded filter has functions of air permeability that is equal to or higher than a PE sintered body CMC filter, short term and long term waterproof properties, and a better microbial barrier property.

Abstract: Embodiments of negative pressure wound therapy apparatuses and methods for using such apparatuses are disclosed. In some embodiments, a negative pressure wound therapy apparatus includes a controller configured to determine a level of exudate in a canister (or a dressing) based at least in part on one or more characteristics of pressure signals generated by a negative pressure source and monitored by a pressure sensor. One such characteristic of the pressure signals can be amplitude, which may increase as a level of exudate in the canister (or dressing) increases. The canister (or dressing) can include a filter configured to become occluded in order to prevent overflow of the canister (or dressing). The controller can be additionally configured to detect and indicate a canister (or dressing) pre-full condition before the filter becomes occluded. More efficient and reliable operation of the negative pressure wound therapy apparatus can thereby be attained.

Abstract: This packaging device includes a housing delimiting a storing chamber. The storing chamber includes a distribution aperture configured to allow passage of one of said medical containers outside the housing so as to allow a user to pick up this medical container. The packaging device also includes a sharps container positioned inside the storing chamber of the housing in a pre-use position, the sharps container being removable from the storing chamber so as to be put outside the housing in a collecting position wherein the sharps container allows collection of the used medical containers. The sharps container is configured to contain the plurality of medical containers in the pre-use position and comprises a spill-out window configured to allow the medical containers to fall down into the storing chamber when the sharps container is moved from the pre-use position to the collecting position.

Abstract: A patient care system is disclosed that includes a medical device such as an infusion pump. The medical device generates a data message containing information such as the status of the therapy being delivered, operating data or both. An alarm generating system assesses the data message from the pump and generates an alarm message if certain conditions established by a first set of rules are met. The alarm message is assessed according to a second set of rules as to whether to suppress the alarm message. The data message contains a required input for both the first and second algorithms. A dispatching system is adapted to forward the alarm message to an alarm destination according to a third set of rules. The alarm destination expresses an alarm upon receipt of the alarm message.

Abstract: A pump for infusing fluid, the pump including a pumping mechanism, a fluid delivery device, a plurality of electric field sensors, and a measurement component. The plurality of electric field sensors is configured to estimate either an electric field that is associated with a patient, or an electric field that is associated with a fluid path of the pump, or both. The measurement component is configured to receive the electric field estimates from each of the electric field sensors and further configured to measure the difference between the electric field estimates.

Abstract: An osmotic actuator (110) for an injection device (100) is disclosed, which osmotic actuator (110) comprises a pressure chamber (180; 280; 380) having one or more outlets (182; 282; 295; 395) and containing a draw solution, one or more osmotic membranes (130), a cavity (140) containing water, and a dilution-compensating arrangement, wherein the one or more osmotic membranes (130) forms a part of an internal surface area of the pressure chamber (180; 280; 380), wherein the cavity (140) containing water abuts at least part of an external surface of the one or more osmotic membranes (130), and wherein the dilution-compensating arrangement is arranged to compensate for the dilution of the draw solution near the one or more osmotic membranes (130), which occurs when water from the cavity (140) enters the pressure chamber (180; 280; 380) through the one or more osmotic membranes (130). Furthermore, an injection device (100) comprising such an osmotic actuator (110) is disclosed.

Abstract: An electric motor (20) usable in proximity to a magnetic resonance imaging (MRI) device (4) includes a stator (30) comprising electrical windings (32), and a rotor (40, 50, 60) magnetically coupled with the stator. The electric motor does not include ferromagnetic material, and the electric motor does not include any permanent magnet. The rotor may include an outer rotor cylinder (50, 60) surrounding the stator, and may further include an inner rotor cylinder (40) disposed inside the stator and connected to rotate with the outer rotor cylinder. The rotor may comprise a cylindrical sheet rotor (40, 50). Alternatively, the rotor (60) may comprise one or more conductive loops (62A, 62B, 62C) each shaped such that the induced voltage in one loop portion (HL1) cancels the effect of the induced voltage in another loop portion (HL2), and a coupled split stator (301, 302). In another disclosed aspect, an infusion pump (10) includes the electric motor.

Abstract: The present disclosure relates to a medical pump for dispensing a liquid. The medical pump comprises a housing, a receptacle and a piston. The housing comprises an inlet for receiving said liquid and an outlet for dispensing said liquid. The receptacle comprises a chamber and a passage that is in fluid communication with the chamber. The receptacle is received in the housing and is axially movable relative to the housing from a filling position, wherein the passage fluidly communicates the chamber with the inlet, to a dispensing position, wherein the passage fluidly communicates the chamber with the outlet. The piston is received in the chamber and is configured such that when the receptacle is in the filling position the piston is axially moveable relative to the receptacle and when the receptacle is in the dispensing position the piston is axially moveable relative to the receptacle.

Abstract: A medical device system is disclosed. The medical device system includes a first medical device and a second medical device. A remote interface including a touch screen is also included. The remote interface is in wireless communication with the first medical device and the second medical device. The remote interface is configured to provide a user interface to the first medical device and the second medical device. The remote interface is configured to receive user input through a touch screen. Also, a charging device is included. The charging device is configured to receive at least the first medical device and the remote interface and the charging device is configured to recharge a first medical device battery and the charging device is configured to recharge an interface battery in the remote interface. The charging device is connected to a personal computer wherein the personal computer provides information to the remote interface.

Abstract: Various embodiments, which relate to an electronic device implanted in tissue of an animal and for delivering stimulation to the neural tissue and operating method thereof, may be configured to generate a control instruction based on a control signal wirelessly received from an external device, and based on the control instruction, to input stimulation through a neural probe formed with flexible material and led out to a predetermined location of the tissue. According to various embodiments, the stimulation includes chemical stimulation by a fluid type of drug, and the neural probe may be formed to flow drug, and may include at least one fluid tube for inputting the chemical stimulation by being opened at one end of the neural probe.

Abstract: Devices and methods useful for injecting therapeutics into the body of a patient are illustrated and described herein. In certain aspects, needle assemblies comprising a needle having a needle shaft with one or more side openings and a needle sheath slidably moveable along the needle shaft to selectively expose or cover all or a portion of the one or more side openings are provided. Such assemblies may include an interference fit between the needle sheath and the needle shaft and/or a seal positioned around the needle shaft proximal of the plurality of one or more side openings and configured to prevent fluid from leaking between the needle sheath and the needle shaft and beyond a proximal end of the needle sheath.

Abstract: Enhanced confirmations for programming of touchscreen infusion pumps reduce the likelihood of users confirming pump parameters that have been mistakenly programmed. Following programming of a given pump parameter, an icon or image intuitively related to the pump parameter can be displayed on the touchscreen. To confirm programming of the parameter, the user can be required to trace the icon on the touchscreen. The user will therefore necessarily associate the confirmation step with the parameter being programmed and be far more likely to realize if a mistake has been made because the user was intending to program a different parameter than with simple confirmations involving the press of a confirmation button.

Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.

Abstract: A method of determining a probability that a patient's blood glucose value is in an adverse range at a prediction time. Spot monitoring blood glucose measurement data is provided and includes blood glucose measurement values and associated measurement times. The values include first and second sets assigned to first and second adverse ranges, respectively. A kernel density estimation and Bayes' rule are used to determine the probability of the blood glucose value of the patient being in the first and second adverse blood glucose ranges at the prediction time. In the kernel density estimation, a first kernel bandwidth is applied for all or some of the first blood glucose measurement values and a second kernel bandwidth different from the first kernel bandwidth is applied for all or some the second blood glucose measurement values. Output data is provided indicative of the prediction time and the probability at the prediction time.

Abstract: An extender for filling a syringe cartridge at a filling station having an elevating bar has a connector portion connecting a proximal portion of the extender to a distal portion of the syringe cartridge. A head on a distal portion of the extender is sized and shaped to engage the elevating bar of the filling station. The syringe cartridge having the extender may be provided to a filling station that is configured for filling a long syringe cartridge having a long syringe-cartridge length greater than a length of the syringe cartridge. The syringe cartridge and extender may be supported on a syringe support of the filling station and passed through the filling station to fill the syringe cartridge.

Abstract: An exemplary embodiment of injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.

Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support includes a supporting beam arranged on the syringe support and biased radially inwards. The supporting beam is adapted to axially bias the syringe in a distal direction within the housing. The disclosure further relates to an autoinjector.