Abstract: According to an aspect, a medical device includes an elongate member having a sidewall. The sidewall defines a lumen. The lumen has a non-circular cross-sectional shape.

Abstract: An endoscope having a multiple diameter working section is disclosed. The endoscope includes a housing, a working section, and a rod-lens optical system. The housing is at a proximal end of the endoscope. The working section is integral with and extends from the housing. The working section includes at least a first section and a second section. The first section is contiguous to the housing, and the second section is at a distal end of the endoscope. The rod-lens optical system is positioned at least partially in the first section of the working section and at least partially in the second section of the working section. The endoscope is defined such that the outer diameter of the first section is larger than the outer diameter of the second section.

Abstract: A method and a system of enhancing ganglion cell function using a gaming environment corresponding to a physical activity. The method and system may be used to implement one or more processes to improve a person's visual processing profile. In particular, the method and system may be used to improve a player's skill in the corresponding physical activity.

Abstract: An anomaloscope comprises a display and a controller of the display. The display has pixels arranged in a plurality of groups, each group containing at least three pixels, each pixel being capable of emitting monochromatic light at a distinct wavelength. The controller of the display causes the display to emit, in at least one of the plurality of groups, light at a first wavelength and causes the display to emit, in at least another one of the plurality of groups, light at two other wavelengths. The controller of the display controls intensities of the light emitted at each of the distinct wavelengths to generate of a pair of metameric colors between the light emitted at the first wavelength and a combination of the light emitted at the two other wavelengths. A method uses the anomaloscope to assess an ability of a subject to discriminate between colors.

Abstract: The disclosed technology is directed to placing two galvanometer mirrors in a pupil conjugate relationship and at the same time preventing astigmatism from occurring while preventing images from being degraded by flaws and foreign matter on a lens. A scanning optical system includes two one-dimensional scanning means disposed closely to each other at a spaced interval therebetween in an optical axis direction for scanning a light beam from a light source in two scanning directions. An objective lens for focusing the light beam scanned by the scanning means onto a target. A plurality of optical elements is disposed in positions spaced from an intermediate image plane in the optical axis direction and having different optical powers in the two scanning directions. The positions and the optical powers of the respective optical elements are set to compensate for the spaced interval between the two scanning means in the optical axis direction.

Abstract: A mobile communication device-based corneal topography system includes an illumination system, an imaging system, a topography processor, an image sensor, and a mobile communication device. The illumination system is configured to generate an illumination pattern reflected off a cornea of a subject. The imaging system is coupled to an image sensor to capture an image of the reflected illumination pattern. A topography processor is coupled to the image sensor to process the image of the reflected illumination pattern. The mobile communications device includes a display, the mobile communications device is operatively coupled to the image sensor. The mobile communications device includes a mobile communications device (MCD) processor. A housing at least partially encloses one or more of the illumination system, the imaging system, or the topography processor.

Abstract: An apparatus for producing a fundus image includes: a processor and a memory; an illumination component including a light source; a camera; and a display, the memory stores instructions that, when executed by the processor, cause the apparatus to: display a target element on the display; display a light source reflection from a cornea of an eye on the display; update a position of the light source reflection on the display as a caregiver manipulates a position of the apparatus relative to the eye; as time elapses, modify the display to allow the light source reflection to more easily be positioned within the target element; and automatically initiate fundus image capture with the camera when the light source reflection is within the target element on the display.

Abstract: A docking station for receiving a hand-held rebound tonometer and a probe container carrying disposable tonometer probes has a docking cavity for receiving a portion of the rebound tonometer and a container receptacle for receiving the probe container. The docking station has an actuation feature arranged to move a cover associated with the probe container from a closed position to an open position as the container is inserted into the container receptacle so that tonometer probes in the container are accessible. The actuation feature may include a projection extending into an entryway leading to the container receptacle for engaging the cover but not the container, such that further insertion of the container moves the cover from the closed to the open position. The docking station may also have a storage recess for receiving an empty probe tube and cap after the probe has been removed from the tube for use.

Abstract: An apparatus, and corresponding method, for determining a refractive property of an eye includes a housing with a port configured to receive an eye and also light from the eye. A tunable lens can be mounted to the housing to apply a variable focal power to the light from the eye and to pass the light along an optical path toward a wavefront sensor within the housing. The wavefront sensor can receive the light via the optical path and measure a wavefront thereof. A determination module can be configured to determine a property of the eye based on the wavefront. Embodiments can be handheld, portable, and open view, while providing objective wavefront aberrometry, subjective phoroptry, and accommodation and presbyoptic evaluation, as well as lensometry functions.

Abstract: Health care monitoring and alerting systems are presented. Contemplated systems include a rule repository storing rules for sending notifications to interested parties regarding a patient's wellness status. An inference engine correlates actual, possibly real-time, patient wellness information with rule sets. If a patient's wellness status satisfies triggering criteria of a rule sets, the inference engine instructs a communication engine to send a notification to interested parties according to the rules set.

Abstract: A device includes an overlay mechanism, system with devices each including an overlay mechanism with an individually programmable delay or method for overlaying data. A method for overlaying data includes redirecting an access which is directed to a first memory location to a second memory location. The method for overlaying data selectively delays access to the second memory location in case of a redirection by a time.

Abstract: A system and method for remote ECG data streaming in real-time is provided. ECG data is encrypted on a physiological monitor placed on a patient via a near-field communication chip on the physiological monitor. A continuous connection is established between the physiological monitor and a cloud-based server via a wireless transceiver on the physiological monitor. The encrypted ECG data is transmitted from the physiological monitor to the cloud-based server. The ECG data is then transmitted from the cloud-based server to a device associated with a medical professional in real-time.

Abstract: Methods, systems, and devices for determining an adaptive health score are described. Methods may include receiving physiological information at a medical device and determining first and second patient health scores based in part on historical patient data and data associated with a larger population. The method may also include assigning complimentary first and second weighted values to the respective scores and, ultimately, determining an adaptive health score for the patient. In addition the method may update, or calculate a new adaptive health score, based on predetermined time intervals, or changes in the type or quantity of physiological data.

Abstract: A computer-assisted patient navigational communication system for receiving electronic and oral communications from a patient, scanning data to determine the medical needs of the patient, and displaying relevant information to appropriate medical personnel who can immediately advise the patient of the most appropriate source of medical assistance relating to the patient's identified symptoms.

Abstract: The present technology relates to vascular access devices, systems, and methods configured to monitor a patient's health. In some embodiments, the vascular access device may include a sensing element, and the system of the present technology may be configured to obtain physiological measurements of the patient via the sensing element, determine at least one physiological parameter based on the physiological measurement, compare the at least one physiological parameter to a predetermined threshold, and, based on the comparison, provide an indication of the patient's health.

Abstract: Methods, systems, and computer readable media for utilizing functional connectivity brain imaging for diagnosis of a neurobehavioral disorder are disclosed. One method for utilizing functional connectivity brain imaging for diagnosis of a neurobehavioral disorder includes receiving brain imaging data for a human subject of a first age, wherein the brain imaging data includes functional connectivity magnetic resonance imaging (fcMRI) data, and predicting, using at least one functional connection between brain locations in the fcMRI data, a neurobehavioral disorder diagnosis for the subject at a second age greater than the first age.

Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.

Abstract: A non-invasive optical measurement system comprises an optical source for generating source light, and an interferometer for splitting the source light into sample light and reference light, delivering the sample light into an anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, and combining the signal light and the reference light into at least three phase-modulated interference light patterns. The optical path lengths of the respective source light and sample light match within a coherence length of the source light.

Abstract: Systems, apparatuses, and methods for detecting carious lesions are described herein. In an example, the systems in an optical interrogator including a single-pixel photodetector responsive to short-wave infrared light and operatively coupled to a controller. In an example the optical interrogator includes a plurality of lasers for emitting laser light, a scanning mirror assembly and a single-pixel photodetector. In an example, the methods include causing the plurality of lasers to emit the laser light having wavelengths in a range of about 900 nm to about 1,700 nm; selectively directing the laser light over different portions of a tooth with a scanning mirror assembly to provide scattered light; and correlating scattered light signals generated by the single-pixel photodetector in response to the scattered light with the portion of the tooth.

Abstract: An intra-oral scanning device includes a main part having a first mount structure, a scanning arm having at least one signal collector, a drive mechanism connected to the scanning arm to move a head portion of the scanning arm, and a mouthpiece positionable in an oral cavity. The mouthpiece has a hollow interior, an opening to access the hollow interior and a second mount structure. The scanning arm extends into the hollow interior when the first mount structure is connected to the second mount structure. The scanning arm is mounted to a pivot manipulator of the drive mechanism such that an axis of rotation of the pivot manipulator is essentially perpendicular to a longitudinal axis of the scanning arm. The scanning arm is mounted to a linear manipulator of the drive mechanism such that a distance between the pivot manipulator and the head portion of the scanning arm is modifiable.

Abstract: A method for monitoring autoregulation includes, using a processor, receiving a blood pressure signal an oxygen saturation signal, and a regional oxygen saturation signal from a patient. The method also includes normalizing the regional oxygen saturation signal to correct for variation in the oxygen saturation signal based on a relationship between the oxygen saturation signal and the regional oxygen saturation signal. The method further includes determining a linear correlation between the blood pressure signal and the normalized regional oxygen saturation signal. The method still further includes providing a signal indicative of the patient's autoregulation status to an output device based on the linear correlation.

Abstract: The reliability of calculated bio-information of a subject is determined. When the reliability of the bio-information is determined to be high, the bio-information is output, whereas when the reliability of the bio-information is determined to be low, the bio-information is not output. Thus, among the calculated bio-information, only the bio-information of high reliability may be output, or distinctive display may be performed depending on the reliability, whereby it is possible to provide a bio-information output device and the like capable of easily determining bio-information of high reliability.

Abstract: The invention provides a body-worn patch sensor for simultaneously measuring a blood pressure (BP), pulse oximetry (SpO2), and other vital signs and hemodynamic parameters from a patient. The patch sensor features a sensing portion having a flexible housing that is worn entirely on the patient's chest and encloses a battery, wireless transmitter, and all the sensor's sensing and electronic components. It measures electrocardiogram (ECG), impedance plethysmogram (IPG), photoplethysmogram (PPG), and phonocardiogram (PCG) waveforms, and collectively processes these to determine the vital signs and hemodynamic parameters. The sensor that measures PPG waveforms also includes a heating element to increase perfusion of tissue on the chest.

Abstract: A device determines values for one or more metrics that indicate the quality of a patient's sleep based on sensed physiological parameter values. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. The sleep quality metric values may be used, for example, to evaluate the effectiveness of a therapy delivered to the patient by a medical device. In some embodiments, determined sleep quality metric values are automatically associated with the therapy parameter sets according to which the medical device delivered the therapy when the physiological parameter values were sensed, and used to evaluate the effectiveness of the various therapy parameter sets. The medical device may deliver the therapy to treat a non-respiratory neurological disorder, such as epilepsy, a movement disorder, or a psychological disorder. The therapy may be, for example, deep brain stimulation (DBS) therapy.

Abstract: A sensor module includes a light emitter that emits light beams including near-infrared light beams towards a subject; a light receiver that receives light beams having passed through the subject; and a controller that estimates biological information based on signals output from the light receiver. The light emitter includes a plurality of light emitting elements that emit near-infrared light beams having central wavelengths different from each other. The light emitter produces sets of light emissions by causing the plurality of light emitting elements to sequentially and intermittently emit the near-infrared light beams. In given two consecutive sets of light emissions produced by the light emitter, a second non-light-emission period of time T4 is longer than a first non-light-emission period of time T2. The controller estimates the biological information in a processing period of time T41 that is set in correspondence with the second non-light-emission period of time T4.

Abstract: Motion activity data is collected from at least one sensor. An initial motion activity classifier function is applied to the motion activity data to produce an initial motion activity posteriorgram. Pre-processing and segmenting the motion activity data into windows produces segmented motion activity data from which sensor specific features are extracted. An updated motion activity classifier function is generated from the extracted sensor specific features. Subsequent motion activity data is also collected from the at least one sensor, and the updated motion activity classifier function is applied to the subsequent motion activity data to produce an updated motion activity posteriorgram.

Abstract: A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.

Abstract: Methods and devices for blood pressure monitoring may include receiving one or more sensor measurements from the at least one sensor. The methods and devices may further include determining at least one of a first blood pressure indication using a first regression representation based on the one or more sensor measurements, a second blood pressure indication using a second regression representation based on the one or more sensor measurements, or a third blood pressure indication using a third regression representation based on the one or more sensor measurements. The methods and devices may include performing a blood pressure selection procedure using the first blood pressure indication, the second blood pressure indication, and the third blood pressure indication to determine an estimated blood pressure indication based on one or more classification characteristics. The methods and devices may further include transmitting the estimated blood pressure indication to the output device.

Abstract: The invention provides a body-worn monitor featuring a processing system that receives a digital data stream from an ECG system. A cable houses the ECG system at one terminal end, and plugs into the processing system, which is worn on the patient's wrist like a conventional wristwatch. The ECG system features: i) a connecting portion connected to multiple electrodes worn by the patient; ii) a differential amplifier that receives electrical signals from each electrode and process them to generate an analog ECG waveform; iii) an analog-to-digital converter that converts the analog ECG waveform into a digital ECG waveform; and iv) a transceiver that transmits a digital data stream representing the digital ECG waveform (or information calculated from the waveform) through the cable and to the processing system. Different ECG systems, typically featuring three, five, or twelve electrodes, can be interchanged with one another.

Abstract: Provided are a method for measuring blood pressure information and a blood pressure measuring apparatus using the same as which improve the battery efficiency, the possibility of portability, and easy measurement of the device equipped with the blood pressure measurement function by both minimizing power consumption and optimizing signal delivery system in the measurement of the blood pressure information using ECG and PPG. The blood pressure measuring apparatus includes a first peak detection unit for detecting a first peak information from an electrocardiographic signal of a patient obtained from an electrocardiogram detection unit; a second peak detection unit for detecting a second peak information from an optical pulse waveform detection signal of the patient obtained from an optical pulse wave detection unit; and a control unit for calculating a pulse wave arrival time information indicating a blood pressure information depending on the first peak information and the second peak information.

Abstract: A system for measuring central venous pressure is provided comprising a device for measuring jugular venous pressure in communication with a patient inclination controller via a processing unit.

Abstract: Protecting a blood pressure cuff and its user is in a sanitary and convenient manner. A shield has upper and lower edges, longitudinal side edges, and interior and exterior surfaces. Stitching couples the side edges. The shield forms a funnel-shaped, generally conical configuration. The upper edge is imperforate, devoid of elastic, and has a first circumference. The shield is fabricated of a flexible material. A continuous elastic band is secured to the shield adjacent the lower edge. The elastic band is adapted to constrict the lower edge to a second circumference when in a relaxed, un-stretched orientation.

Abstract: A system may intermittently illuminate a region, detect light from the intermittently illuminated region to form a detected signal, and process the detected signal with a demodulator. The demodulator may include a capacitor having an input to receive the detected signal, a resistor having an input connected to an output of the capacitor at a connection point, and a switch that connects the connection point to ground during times when the region is not illuminated. An output of the resistor may produce an output signal that is a high-pass filtered version of the detected signal during times when the region is illuminated, and a time-invariant ground signal during times when the region is not illuminated. Such a demodulator may reduce the effects of low-frequency noise sources, such as background light, op-amp offsets related to input bias, photodiode 1/f noise and dark current.

Abstract: Some embodiments provide a wearable monitoring device including a motion sensor and a photo (PPG) sensor. The PPG sensor includes (i) a periodic light source, (ii) a photo detector, and (iii) circuitry determining a user's heart rate from an output of the photo detector. Some embodiments provide methods for operating a heart rate monitor of a wearable monitoring device to measure one or more characteristics of a heartbeat waveform. Some embodiments provide methods for operating the wearable monitoring device in a low power state when the device determines that the device is not worn by a user.

Abstract: Methods and systems for characterizing tissue of a subject include acquiring and receiving data for a plurality of time series of fluorescence images, identifying one or more attributes of the data relevant to a clinical characterization of the tissue, and categorizing the data into clusters based on the attributes such that the data in the same cluster are more similar to each other than the data in different clusters, wherein the clusters characterize the tissue. The methods and systems further include receiving data for a subject time series of fluorescence images, associating a respective cluster with each of a plurality of subregions in the subject time series of fluorescence images, and generating a subject spatial map based on the clusters for the plurality of subregions in the subject time series of fluorescence images. The generated spatial maps may then be used as input for tissue diagnostics using supervised machine learning.

Abstract: NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.

Abstract: Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state.

Abstract: In various specific embodiments, a localizer can include a plurality of coil groups, where each coil group includes three coils that are formed around a single center. Each of the three coils can be formed around separate jigs and the jigs can be interconnected to form the coil group. The jigs need not be annular, but may be formed in any appropriate configuration of shape or geometry for forming the final coil group.

Abstract: A method and wireless sensor device for determining body postures and activities. In one aspect, a method includes receiving sensor data. The method also includes detecting and classifying a body transition of a body based on the sensor data. The method also includes detecting if there is activity of the body based on the sensor data. If there is activity, the method also includes classifying the activity. If there is no activity, the method also includes classifying a rest position of the body based on the sensor data and based on a previous body transition.

Abstract: A system for thermoregulatory sweat testing of a subject includes a chamber for accommodating the subject, the chamber having a heating device for operably elevating the core body temperature of the subject to a target temperature so as to induce sweating over a skin surface of the subject; a cooling device for operably creating forced evaporative cooling of the skin surface of the subject after the core body temperature of the subject is elevated to the target temperature; an imaging device for acquiring images of the subject at different times, each image having imaged pixels, the imaging device including one or more infrared cameras, one or more infrared sensors, or a combination of them; and a controller coupled with the chamber and the imaging device for controlling operations of the chamber and the imaging device and processing the acquired images to determine skin surface sweat distributions of the subject.

Abstract: The present disclosure relates to devices and methods for non-invasive measuring of analytes. At least one embodiment relates to a wearable system for non-invasive measuring of a concentration of an analyte in skin tissue. The wearable system includes an integrated circuit that includes a first optical unit. The first optical unit includes a Raman spectrometer. The first optical unit also includes an OCT spectrometer and an interferometer optically coupled to the OCT spectrometer or an infrared (IR) spectrometer. The first optical unit additionally includes a light coupler. The wearable system further includes a first light source for performing Raman spectroscopy. The wearable system additionally includes a second light source for performing OCT spectroscopy or IR spectroscopy. Still further, the wearable system includes read-out electronics to determine an optical model of the skin tissue based on the spectroscopic data and to determine the concentration of the analyte.

Abstract: Provided is a brain function measurement device capable of improving the reliability of brain function measurement using a simple configuration. The brain function measurement device includes light source probes LD2 and LD12 for irradiating the scalp of a test subject with light beams; linearly polarizing films P2 and P3 for polarizing the light beams emitted from the light source probes LD2 and LD12 in a first direction; a linearly polarizing film P1 for blocking components in the first direction of reflected light beams that are generated as the light beams emitted from the linearly polarizing film P2 and P3 are reflected by the hairs of the test subject; and a detection probe PD1 for detecting the intensity of a light beam that has passed through the linearly polarizing film P1.

Abstract: A monitoring system includes a surgical implant configured for implantation in vivo and having at least one sensing fiber configured to measure a preselected physiological parameter, and a receiving unit in wireless communication with the at least one sensing fiber and configured to receive measurements of the preselected physiological parameter. A surgical system includes an end effector having a plurality of fasteners, and a surgical implant securable to tissue via the plurality of fasteners. The surgical implant includes at least one sensing fiber configured to measure a preselected physiological parameter.

Abstract: A method providing a signal quality degree associated with an analyte value measured in a continuous monitoring system is disclosed. The method includes: receiving a measured analyte value from a biosensor; determining at least two impact parameters, wherein each of the impact parameters is influenced by an operational status of the continuous monitoring system and wherein each of the impact parameters is capable of exerting an influence on the signal quality of the biosensor and wherein the influence of each of the impact parameters on the signal quality of the biosensor is expressed by a weight assigned to each of the impact parameters; and determining the signal quality degree associated with the measured analyte value as a function of the weights and the corresponding impact parameters; and providing the signal quality degree associated with the analyte value. A method of calibration using the signal quality degree is also disclosed.

Abstract: The present application provides a Capillary number-based method of isolating circulating rare cells from a blood sample from a subject using filtration parameters determined based on the measurement of hemorheological parameters of the sample. The present application also provides a method for determining filtration parameters in a microfluidic elasto-filtration process for isolating circulating rare cells from a blood sample from a subject. The present application further provides a device for isolating circulating rare cells from a blood sample from a subject and a non-transitory computer storage medium for performing methods described in the present application.

Abstract: Exemplary embodiments described in this disclosure are generally directed to systems and methods for reducing anxiety in an occupant of a vehicle. In one exemplary method, a computer that is provided in a vehicle receives from a source such as a server computer, information that is used to determine a behavioral profile of an occupant of the vehicle. The computer utilizes the behavioral profile to identify a behavior characteristic of the occupant. The behavior characteristic is matched by the computer to one of various behavior categories such as an amaxophobia sufferer category or a controlling personality category. The computer then executes one or more operations in the vehicle based on the behavior category to which the occupant belongs. If the occupant belongs to the amaxophobia sufferer category, the computer may, for example, play an audio track, display a video clip, and/or change a driving characteristic of the vehicle.

Abstract: A method for providing a neural interface system. At least one primary metallization layer is deposited on a substrate. The primary metallization layer has a thickness. A monolayer of nanospheres is deposited in a substantially uniform distribution. The nanospheres contact an upper surface of the primary metallization layer. The upper surface of the primary metallization layer not contacted by the nanospheres is treated to form a plurality of undulating structures having a substantially uniform arrangement. The treating comprises etching recesses part-way through the thickness of exposed portions of the primary metallization layer from the upper surface thereof.

Abstract: An electrical patch and associated system for acquisition of physiological data is described. The patch has a design that enables a variety of configurations depending upon the requirements physiological measurements to be made. Patches with single input channels to patches with multiple input channels, processing capabilities and radio communication can all use the same physical configuration. The design includes a battery management system to enable long term data acquisition and an optimization process that includes mirroring of algorithms on the patch and devices local to the user with algorithms running on a centrally located server. The server can then optimize data acquisition and analysis algorithms. The components of the system and methods of use are included.

Abstract: A portable medical device having improved ECG trace display and reporting. Embodiments implement features to ameliorate artifacts created by virtue of attempting to eliminate compression artifacts due to mechanical compression devices. Other embodiments additionally implement features to seek to detect the occurrence of ROSC while chest compressions are ongoing.

Abstract: The present disclosure provides systems and methods for detecting cardiac activation times of a patient. A system includes a data acquisition system and a processor communicatively coupled thereto. The data acquisition system is configured to detect a plurality of electrograms generated at a plurality of respective electrodes coupled to the patient. The processor is configured to receive the plurality of electrograms from the data acquisition system. The processor is further configured to compute respective energies of the plurality of electrograms. The processor is further configured to detect a cardiac activation time for a first electrogram among the plurality of electrograms based on the respective energy of the first electrogram and the respective energy of a second electrogram that neighbors the first electrogram.