Patents Issued in September 2, 2021
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Publication number: 20210268209Abstract: A nebulizer (10) comprising a housing which defines, a chamber that has an outlet to the chamber for the egress of atomised fluid particles from within the chamber. The nebulizer (10) further including solid substrate (11) within the chamber of the housing. A linear channel (12) being formed in the substrate (11) that has a closed base, opposite side walls and an opening that opens through an upper surface of the substrate (11). A vibration generator (17) being attached to the substrate (11) at a position spaced from the channel (12) for generating high frequency vibration that transmits through the substrate (11) to the channel (12) to atomise fluid within the channel (12). A feeding facility (15) being provided for feeding fluid to the channel (12).Type: ApplicationFiled: July 24, 2019Publication date: September 2, 2021Inventors: Tuncay Alan, Adrian Neild, Nguyen Hoai An Le, Jason Brenker
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Publication number: 20210268210Abstract: A compact modular multifunctional inhalation device including a housing having an inlet port and an outlet port; a removable cartridge module adapted to seat within the housing, the cartridge including: a tray within the cartridge for holding a solid inhalant, a heating element mounted within the cartridge above and through the tray for heating the inhalant; and a removable modular electronic circuit adapted to seat within the housing to provide electrical current to the heating element. The heating element is a coil mounted within a chamber in thermal proximity to the solid inhalant. A quartz rod is mounted within the coil. A plunger is mounted within the cartridge to translate therein and compact the solid inhalant. In an alternative embodiment, dual channels and outlet ports are mounted in communication with an inlet port. In another embodiment, the cartridge is a split chamber cartridge with a split plunger mounted therein.Type: ApplicationFiled: March 2, 2020Publication date: September 2, 2021Inventors: Peter Daniel Klurfeld, Douglas Cohen, Elliott Galynsky
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Publication number: 20210268211Abstract: A system is disclosed for performing an endoscopic surgical procedure in a surgical cavity, which includes a multi-modal gas delivery device including a primary gas circulation pump, a secondary gas circulation pump and an insufflation subunit, and an interface plate adapted and configured to engage with the multi-modal gas delivery device and including a connector and a filter seat corresponding to five different lumens, each of which provides a different functionality.Type: ApplicationFiled: May 18, 2021Publication date: September 2, 2021Applicant: Conmed CorporationInventors: Mikiya Silver, Michael J. Kane, Michael J. Augelli
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Publication number: 20210268212Abstract: An inhalation interface may monitor and analyze flow rate in an inhalation device. The inhalation interface may be calibrated for a user. The inhalation interface may send usage data to a user for review. In some embodiments the inhalation interface may send usage data to a physician and provide active feedback to a patient. The active feedback may indicate when the flow rate during an inhalation is within a target threshold.Type: ApplicationFiled: July 10, 2019Publication date: September 2, 2021Inventor: Christopher V. CIANCONE
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Publication number: 20210268213Abstract: A cartridge for a dispensing device, such as a nebulizer, for dispensing a medicament composed of or produced from a plurality of components and a system including a dispensing device, such as a nebulizer, and such a cartridge. The cartridge includes at least two fluidically separated chambers which each contain at least one component of the medicament, an actuating mechanism for fluidically connecting the chambers and mixing the components for the dispensing of the medicament A method for preparing a medicament composed of a plurality of components in a cartridge for the dispensing of said medicament by way of a dispensing device, such as a nebulizer, where a plurality of fluidically separated chambers of the cartridge are fluidically connected, and a component of the medicament is at least partially transferred from one of the chambers to another of the chambers with another component of the medicament in order to mix the components.Type: ApplicationFiled: June 12, 2019Publication date: September 2, 2021Applicant: Boehringer Ingelheim International GmbHInventors: Andree JUNG, Stephen Terence DUNNE, Joachim Carl Herbert EICHER
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Publication number: 20210268214Abstract: The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation, a mouthpiece mounted to the housing through which the medicament is inhaled by a user, an indexing and opening mechanism for indexing the blister strip and for opening the blisters which is operated by an actuator, wherein the blister strip is indexed by forward motion of the actuator from a first position to a second position, such as by opening a cover, and is also indexed in the same direction by reverse motion of the actuator from the second position to the first position, such as by closing the cover.Type: ApplicationFiled: September 16, 2019Publication date: September 2, 2021Applicant: VECTURA DELIVERY DEVICES LIMITEDInventors: Roger CLARKE, Andreas MELINIOTIS
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Publication number: 20210268215Abstract: A smoking-cessation device and method includes a vaporization device and smoking-cessation method. The device includes two pods, each of which is a consumable, interchangeable component that contains a capsule tank with a measured amount of vaporizable liquid. Measures of a substance containing a drug such as nicotine may be delivered via instructions from a computer-readable medium to each pod as part of a smoking-cessation regimen. The regimen can be changed and reprogrammed by a medical practitioner to delivery varying amounts of drug according to a person's adherence to a defined smoking-cessation regimen. Eventually the drug dosage will be reduced, and the non-drug liquid will increase until the user reduces his or her dependence on the drug.Type: ApplicationFiled: March 2, 2020Publication date: September 2, 2021Inventors: Joshua Israel, Devin Serago
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Publication number: 20210268216Abstract: An aerosol delivery device includes at least one housing, a heating element, a sensor, and a microprocessor coupled to the heating element and the sensor. The at least one housing encloses a reservoir configured to retain an aerosol precursor composition. The sensor is configured to produce measurements of differential pressure between an ambient atmospheric pressure and a pressure caused by airflow through at least a portion of the aerosol delivery device. The sensor is also configured to convert the measurements of differential pressure to corresponding electrical signals. The microprocessor is configured to receive the corresponding electrical signals and operate in an active mode only in an instance in which the differential pressure is at least a threshold differential pressure. The microprocessor in the active mode is configured to control the heating element to activate and vaporize components of the aerosol precursor composition.Type: ApplicationFiled: May 18, 2021Publication date: September 2, 2021Inventor: Rajesh Sur
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Publication number: 20210268217Abstract: A nasal spray device can include housing having a sensor and a nozzle having a housing interface with a graphical image thereon. The sensor can be configured to sense movement of the graphical image when the nozzle moves relative to the housing, for instance during administration of medicine from the nasal spray device. The sensor can include an infrared proximity sensor that senses infrared reflectivity from the graphical image. The infrared proximity sensor can also be used to measure distance to a surface of a vial within the housing to thereby detect insertion of the vial into the housing.Type: ApplicationFiled: May 6, 2021Publication date: September 2, 2021Applicant: Validose, Inc.Inventors: Marcel BOTHA, Frederick Zacharias KRUGER, Johannes Michiel BREDENKAMP
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Publication number: 20210268218Abstract: A gas delivery component of a CPAP system is configured to magnetically connect to a second gas delivery component of the CPAP system to deliver a pressurized flow of breathable gas to a patient's airways. The gas delivery component includes a lumen forming a first part of a gas flow path for the breathable gas. A connection end of the gas delivery component is configured to engage the second gas delivery component. In addition, a magnetic connection assembly is located at the connection end and includes a magnet positioned at least partially within the lumen. The magnetic connection assembly is configured to magnetically secure the gas delivery component to the second gas delivery component.Type: ApplicationFiled: May 21, 2021Publication date: September 2, 2021Inventors: Renee Frances FLOWER, Chun Yui LAU, Philip Rodney KWOK, Christopher John BAXTER, Angelene Marie OZOLINS, Paul Anthony GREEN
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Publication number: 20210268219Abstract: A respiratory interface device is provided that includes a cushion and a faceplate. The cushion is structured to be coupled to the faceplate. The faceplate includes a peripheral end and a number of custom features. The cushion is coupled to the faceplate adjacent the faceplate peripheral end.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Inventors: JONATHAN SAYER GRASHOW, LAUREN PATRICIA CHODKOWSKI, DAVID W. SMITH
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Publication number: 20210268220Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Inventors: Michiel KOOIJ, Alexander Joel BENTLEY, Igor BESIC, Robert Thomas BURNHAM, Aaron Samuel DAVIDSON, Priyanshu GUPTA, Kirrily Michele HASKARD, Ryan Michael KIRKPATRICK, Luke Emmanuel KLINKENBERG, Dimitri Marco MAURER, Joseph Samuel ORMROD, Gerard Michael RUMMERY, Rupert Christian SCHEINER, Bishavjot SINGH, Christopher James SMITH, Lochlan VON MOGER, Paul Derrick WATSON, Daniel Marc WEISS, Hadley WHITE
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Publication number: 20210268221Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: March 10, 2021Publication date: September 2, 2021Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Publication number: 20210268222Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Inventors: Alexander VIRR, Andrew Roderick BATH, Nathan John ROW, Dan KAO, Phoebe Katherine HILL, Nicholas Andrew EARL, Hargopal VERMA, Junning CHEN
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Publication number: 20210268223Abstract: An apparatus for humidifying a flow of pressurised, breathable air includes varying a first pressure of the flow of breathable gas to vary a level of thermal engagement between the conductive portion of the reservoir and the heater plate, varying a height of the variable portion varies a level of thermal engagement between the conductive portion of the reservoir and the heater plate, use of a humidifier reservoir base component with a maximum water capacity substantially equal to the predetermined maximum volume of water of the humidifier reservoir or the use of intersecting inlet and outlet axes.Type: ApplicationFiled: May 18, 2021Publication date: September 2, 2021Inventors: Andrew Roderick BATH, Justin John FORMICA, Matthew Rolf HARRINGTON, Joseph Samuel ORMROD, Luke Andrew STANISLAS, Hargopal VERMA
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Publication number: 20210268224Abstract: This invention relates to a humidification assembly or kit for use in a respiratory support system for delivering humidified gas to a user or patient. The assembly or kit comprises a fluid reservoir, and a humidification chamber. The fluid reservoir and the humidification chamber are provided in fluid connection with each other, wherein a connection between each of the fluid reservoir and the humidification chamber provides a pre-determined force of retention and/or resistance to disconnection or is a permanent type connection.Type: ApplicationFiled: August 30, 2019Publication date: September 2, 2021Inventors: Craig Karl White, Gareth Thomas McDermott, Cameron Leslie Matthews, Shane Terry Massey
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Publication number: 20210268225Abstract: Provided are methods of regulating stress comprising providing an individual with bilaterally-position-able stimulation devices and a mobile device controller comprising memory including initial stimulation settings applied in response to event-associated sensor data and population data associated with bilateral stimulation stress reduction; placing sensor(s) near/on the individual; analyzing sensor data to assess if may indicate a new stress-increasing event/condition, causing the mobile device processor to determine if any such new event/condition is learnable, causing the controller to generate a proposed new stimulation model regarding any learnable event/condition, evaluating the proposed new stimulation model by comparing the new event/condition to the population data, the event or condition of the initial model, or both, and adopting and applying the proposed new stimulation model if the new stimulation model does not vary from the population data, the event/condition of the initial model, or both, byType: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Inventors: Vicki Mayo, Amy Serin, Jack Maxwell Vice
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Publication number: 20210268226Abstract: The present invention provides systems, methods, and articles for stress reduction and sleep promotion. A stress reduction and sleep promotion system includes at least one remote device and an article for temperature conditioning a surface. The stress reduction and sleep promotion system includes at least one body sensor, at least one remote server, and/or a pulsed electromagnetic frequency device in other embodiments.Type: ApplicationFiled: May 18, 2021Publication date: September 2, 2021Applicant: Kryo, Inc.Inventors: Todd Youngblood, Tara Youngblood
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Publication number: 20210268227Abstract: An infant calming/sleep-aid/SIDS detection device is provided that includes a main moving platform that moves in a variable manner with accompanying variable sound generation, the sound and motion adapted to calm a fussy baby, induce sleep, and maintain sleep under normal conditions. The device may also have a sensor for detection of pauses in breathing and/or detection of resultant biological changes related to breathing pauses and respond with appropriate stimuli to arouse the baby and allow breathing to recommence.Type: ApplicationFiled: May 20, 2021Publication date: September 2, 2021Applicant: HB Innovations, Inc.Inventors: Harvey Neil Karp, Matthew R. Berlin, Jesse V. Gray, Bill Walter Washabaugh, Deb Kumar Roy
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Publication number: 20210268228Abstract: Catheters, sheaths, or other tubular devices are provided that include a proximal end, a distal end sized for introduction into a patient's body, and a steerable distal portion. The tubular device includes a primary lumen extending between the proximal and distal ends; an auxiliary lumen adjacent the primary lumen; and one or more reinforcement members including windings extending helically along at least the distal portion, at least some of the windings passing between the primary and steering element lumens and at least some of the windings surrounding both the primary and steering element lumens. In one embodiment, a steering element is slidably disposed within the auxiliary lumen. Apparatus and methods for making such tubular devices are also provided.Type: ApplicationFiled: March 15, 2021Publication date: September 2, 2021Inventors: Stephen A. Leeflang, Christian S. Eversull
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Publication number: 20210268229Abstract: A catheter with optic shape sensing capabilities is described. The catheter features an elongated tubing, one or more septums and one or more micro-lumens formed in an axial wall of the tubing and/or the one or more septums. A single core optical fiber can be configured to reside within each of the micro-lumens, the optical fibers in the plurality of lumens being spatially distributed to sense strain and return light signals with characteristics that identify the sensed strain for three-dimensional rendering of the catheter by a console during insertion into a body of a patient.Type: ApplicationFiled: February 26, 2021Publication date: September 2, 2021Inventors: Steffan Sowards, Anthony K. Misener
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Publication number: 20210268230Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.Type: ApplicationFiled: May 4, 2021Publication date: September 2, 2021Inventor: Sean McDermott
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Publication number: 20210268231Abstract: A vascular interventional instrument control device capable of operating double guide wires or balloons, includes a main finger assembly, a first sub-finger assembly, a second sub-finger assembly, a driving assembly and a clamping assembly, wherein the main finger assembly, the sub-finger assembly, the driving assembly and the clamping assembly are separately installed to the body structural member and separately connected to the controller through a communication link, one of the operated double guide wires or balloons is clamped by the main finger assembly and the first sub-finger assembly, and the other is clamped by the main finger assembly and the second sub-finger assembly; and the operated double guide wires or double balloons can be separately moved axially or rotated about its own axial direction.Type: ApplicationFiled: November 12, 2019Publication date: September 2, 2021Applicant: INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCESInventors: Xiaoliang XIE, Zengguang HOU, Lingwu MENG, Zhenqiu FENG, Xiaohu ZHOU, Shiqi LIU
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Publication number: 20210268232Abstract: A catheter insertion system enabling a catheter to be inserted smoothly, a catheter insertion method, and an insertion unit. A catheter insertion system includes: a first holding portion holding an elongated catheter and capable of moving forward in a axial direction of the catheter; a second holding portion holding the catheter on a side proximal as compared with the first holding portion and capable of moving forward in the axial direction of the catheter; and an insertion control unit controlling the operation of the first holding portion and the second holding portion. The insertion control unit controls the operation of the first holding portion and the second holding portion such that only the first holding portion moves forward in a state where the catheter is bent by the second holding portion being moved forward toward the first holding portion.Type: ApplicationFiled: May 20, 2021Publication date: September 2, 2021Applicant: TERUMO KABUSHIKI KAISHAInventor: Hideki KATSURA
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Publication number: 20210268233Abstract: Disclosed herein are a range of stiffening mechanisms or systems that assist or enable holding a pose or shape of a flexible body (1010, 216, 410, 420, 801). These stiffening mechanisms may be part of the steering mechanism (500, 800), may be separately actuated and/or may themselves also enable steering of the flexible elongate device (400).Type: ApplicationFiled: June 19, 2019Publication date: September 2, 2021Inventors: Joseph D. BOGUSKY, Randall L. SCHLESINGER
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Publication number: 20210268234Abstract: A deflectable catheter shaft section is disclosed comprising an elongated body extending along a longitudinal axis with a distal end and a proximal end. First and second pull wires can extend along the elongated body and can have a proximal end and a distal end. First and second pull wire liners can be disposed over a portion of one of the first and second pull wires, respectively. Each of the first and second pull wires can have a proximal end and a distal end. A first gap can exist between the proximal end of the first pull wire liner and the proximal end of the elongated body and a second gap can exist between the proximal end of the second pull wire liner and the proximal end of the elongated body.Type: ApplicationFiled: March 8, 2021Publication date: September 2, 2021Inventors: Zachary L. Helgeson, Troy T. Tegg, Alexander C. Houck, Xuan Y. Khieu, Salome A. Gonzalez, Somally Mom, John Her
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Publication number: 20210268235Abstract: A pull wire attachment system for a minimally invasive medical instrument comprises an anchoring element fixedly attached to the medical instrument. The anchoring element has a first outer diameter. The system also includes a pull wire assembly comprising an elongate pull wire having a proximal end and a distal end and a securing element coupled to the distal end of the pull wire. The securing element includes a second outer diameter sized smaller than the first outer diameter of the anchoring element. The securing element is coupled to the anchoring element to prevent proximal translation of the distal end of the pull wire along a longitudinal axis of the medical instrument past the anchoring element.Type: ApplicationFiled: May 11, 2021Publication date: September 2, 2021Inventor: Randall L. Schlesinger
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Publication number: 20210268236Abstract: Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor such that orientation of the spherical member is permitted about three mutually perpendicular axes.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Inventors: Brian D. Nelson, Jeffrey P. Bodner
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Publication number: 20210268237Abstract: An introducer tool including a housing, a sheath detachably coupled to the housing, and a needle fixed to the housing. The housing can include a guidewire actuating mechanism configured to extend and retract a guidewire fixed to the guidewire actuating mechanism. The sheath can include a handle, and can be detachably coupled to the housing in a first configuration of the introducer tool designed for venous introduction of the sheath. An end portion of the needle can extend past an end portion of the sheath in the first configuration of the introducer tool. Methods for venous access including obtaining and using the introducer tool are also disclosed.Type: ApplicationFiled: June 19, 2019Publication date: September 2, 2021Inventors: Christian Andersen, John G. Evans
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Publication number: 20210268238Abstract: Valve assemblies having improved ability to selectively control flow of fluids through the catheter and prevent leakage of fluids from the proximal end of a catheter that is positioned within a patient. Such improved catheter valve assemblies also prevent leakage of fluids after repeated insertion and removal of medical instruments through the valve.Type: ApplicationFiled: May 4, 2021Publication date: September 2, 2021Inventors: Clint SOLOMON, Vincent LESKOWICH, Thomas SUTTON, James HALE, Jacob HENTZLER
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Publication number: 20210268239Abstract: A catheter assembly includes a catheter, a catheter hub fixed to the proximal end portion of the catheter, a hollow inner needle removably located in the catheter and including a distal end portion at which is located a needlepoint to puncture skin of a patient, and a guide wire slidably positioned in the inner needle. The guide wire is longer than both the inner needle and the catheter. A wire operating member is connected to the guide wire and is displaceable in the forward direction relative to the inner needle and the catheter. A main body is detachably connected to the catheter hub and includes a finger-engaging projection at a distal portion of the main body that is engageable by a user's finger to advance the main body and the catheter in the forward direction.Type: ApplicationFiled: May 7, 2021Publication date: September 2, 2021Applicant: TERUMO KABUSHIKI KAISHAInventor: Masahiro Ishida
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Publication number: 20210268240Abstract: Butterfly assemblies to deliver a fluid into a patient's anatomic space include a body and extensions. The body has an opening to receive a needle to penetrate into a patient's anatomic space, and the extensions are hinged to the body and movable between a closed, compact position and an expanded, open position without significant biasing forces tending to move the extensions into either position. Each extension has an outer periphery at least partially surrounding an interior surface having a locking structure to mate with the other extension and lock the extensions together in the closed, compact position.Type: ApplicationFiled: March 12, 2021Publication date: September 2, 2021Applicant: INNOVATIVE HEALTH SCIENCES, LLCInventor: Andrew SEALFON
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Publication number: 20210268241Abstract: A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.Type: ApplicationFiled: February 19, 2021Publication date: September 2, 2021Applicant: Boston Scientific Scimed, Inc.Inventors: Lauren LYDECKER, Andrew PIC, Martin BURKE, Juan Pablo ORTIZ GARCIA, Travis HENCHIE, John FAVREAU, Jessica POWERS
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Publication number: 20210268242Abstract: An apparatus for assisting in the introduction of a flexible wire into a device having a comparable sized lumen. An exemplary apparatus includes a first portion having a distal end, a proximal end, a slot and a lumen exposed at the distal end, the proximal end and the slot, and a second portion having a distal end, a proximal end, a slot and a lumen exposed at the distal end, the proximal end and the slot of the second portion. The second portion is slidably and rotatably received with the lumen of the first portion. A gripping device is attached at the proximal end of the second portion. The gripping device causes at least a portion of the proximal end of the second portion to have a reduced inner diameter when a gripping force is applied to the gripping device.Type: ApplicationFiled: March 2, 2021Publication date: September 2, 2021Inventor: Brandon J. Shuman
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Publication number: 20210268243Abstract: In an example, a method for delivery of a therapeutic agent to at least one of a palatine canal or a pterygopalatine fossa of a patient is described. The method includes inserting a delivery device into a nasal cavity of a patient. The delivery device includes an elongated shaft with a proximal end and a distal end, a handpiece coupled to the proximal end of the elongated shaft, and a boring element disposed on the distal end of the elongated shaft. The method also includes advancing the distal end of the elongated shaft to a position proximate to a palatine bone within the nasal cavity, actuating the boring element to form a passage in the palatine bone between the nasal cavity and a palatine canal of the patient, and delivering a therapeutic agent into the palatine canal.Type: ApplicationFiled: June 14, 2019Publication date: September 2, 2021Inventors: William Jason Fox, Brian Fahey, Mojgan Saadat, Vahid Saadat
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Publication number: 20210268244Abstract: Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to deliver the active ingredient into an external environment based on the activation of the stimuli responsive actuator. In an example, the active ingredient is released into the external environment, whereas in another example, the active ingredient is injected into the external environment.Type: ApplicationFiled: May 14, 2021Publication date: September 2, 2021Inventors: Robert Niichel, Douglas A. Miller
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Publication number: 20210268245Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Inventors: Edward H. Cully, Edward Gunzel, Keith Knisley, Greg Rusch, Lauren Zambotti
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Publication number: 20210268246Abstract: An applicator is disclosed for applying a treatment solution to a treatment site of a patient. The applicator can include an applicator housing comprising a treatment solution reservoir. A cartridge can be removably disposed in the housing. The cartridge when arranged in the housing can be in fluid communication with the treatment solution reservoir. The cartridge can include an electrostatic module for electrostatically charging the treatment solution in the treatment solution reservoir; and a nozzle for applying the treatment solution.Type: ApplicationFiled: November 18, 2019Publication date: September 2, 2021Applicant: Octet Medical, Inc.Inventor: Clifford A. WRIGHT
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Publication number: 20210268247Abstract: Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.Type: ApplicationFiled: February 11, 2021Publication date: September 2, 2021Inventors: Michael STORY, Debabrata SAHA, Narasimha Kumar KARANAM
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Publication number: 20210268248Abstract: Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 ?m to 1000 ?m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Inventors: Mohamed R. Ahmed, Jayakumar Rajadas, Wenchao Sun, Mohammed Inayathullah Nazir Ahmed, Feng Xu
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Publication number: 20210268249Abstract: The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.Type: ApplicationFiled: May 21, 2021Publication date: September 2, 2021Inventors: Dennis Cornelis Franciscus BEELEN, Martin VAN HARMELEN, Robertus Theodoor Maria MOORMANN, Maurice Petrus Wilhelmus TAK
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Publication number: 20210268250Abstract: An inflatable port including a housing, a chamber in the housing, a septum over the chamber, a hollow stem extending from the housing, and a bladder around at least a portion of the housing. The chamber has a major opening and a minor opening. The septum is positioned over the major opening of the chamber and is fixed to the housing. The stem fluidly connects to the chamber by way of the minor opening of the chamber. The bladder is configured to increase a size of the inflatable port upon inflation of the bladder and decrease the size of the inflatable port upon deflation of the bladder. Also disclosed herein is a catheter assembly including the inflatable port, as well as a method related to the foregoing inflatable port and catheter assembly.Type: ApplicationFiled: June 20, 2019Publication date: September 2, 2021Inventor: John G. Evans
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Publication number: 20210268251Abstract: Disclosed herein is an implantable port and an implantable port-detecting device (“IPDD”). The implantable port includes a housing and a septum over a portion of the housing. At least one of the housing or the septum incorporates a contrast agent for locating the septum of the implantable port when the implantable port is implanted in a patient. The IPDD includes a light source, a light detector, and a display configured to display a presence of the implantable port. The light source is configured to emit light in a near-infrared (“NIR”) range of wavelengths as incident light for absorption by the contrast agent. The light detector is configured to detect light in the NIR range of wavelengths including luminescent light emitted by the contrast agent. The display is configured to display a presence of the implantable port when the luminescent light from the contrast agent is detected by the light detector.Type: ApplicationFiled: July 12, 2019Publication date: September 2, 2021Applicant: Bard Peripheral Vascular, Inc.Inventors: Andrzej J. Chanduszko, Peng Zheng, Sima Jalaleddine, Joceline D. Cooks, Jeremy B. Cox
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Publication number: 20210268252Abstract: Endovascular drug delivery systems and methods are disclosed herein for delivering a therapeutic agent to the intracranial subarachnoid space of a patient, and/or deploying an endovascular drug delivery device distal portion in the intracranial subarachnoid space and a portion of the drug delivery device body in a dural venous sinus such that a therapeutic agent is delivered from the deployed drug delivery device into the intracranial subarachnoid space.Type: ApplicationFiled: May 11, 2021Publication date: September 2, 2021Applicant: CEREVASC, INC.Inventors: Adel M. Malek, Carl B. Heilman, David A. Rezac, Jack B. Sattell, Alexander Bonin
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Publication number: 20210268253Abstract: Percutaneous access devices (PAD) or other implantable medical devices formed with chain mail are provided. The use of chain mail allows for a flexible PAD that promotes the formation of natural biologic seals between the skin and the device to form a barrier to microbial invasion into the body. Percutaneous access devices may be used for cardiac assist systems, peritoneal dialysis catheters, Steinman pin, Kirschner wires, chronic indwelling venous access catheters that require skin penetration, and osseo-integrated percutaneous medical appliances. Unlike conventional chain mail that is only formed in two dimensional sheets, chain mail is formed in elongated linear chains with occasional interlinks, two dimensional sheets, and in other configurations and combinations including three dimensional structures, pendant petals, elongated linear chains, combined fractal structures having a non-integer dimensionality intermediate between 1 and 3, and combinations thereof.Type: ApplicationFiled: May 14, 2021Publication date: September 2, 2021Applicant: Cardiac Assist Holdings, LLCInventor: Allen B. Kantrowitz
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Publication number: 20210268254Abstract: Infusion connection lines for use in infusion sets are provided. The infusion connection line includes a pump infusion tube having connectors at both ends and an indicator element for showing the installation direction within an infusion pump is disposed between the connectors. The infusion connection line is configured to connect a gravity IV set to any type of infusion pump while improving the pump infusion accuracy and minimizing tube leakage or breakage over directly connecting the gravity IV set to the infusion pump. The infusion connection line may be disconnected and disposed of after use without requiring disposal of the rest of the pump IV infusion set and/or components.Type: ApplicationFiled: March 2, 2020Publication date: September 2, 2021Inventor: Steven ZHU
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Publication number: 20210268255Abstract: A system for the safe and secure connection of medical fluid lines is provided. A shell has an upper portion and a lower portion and the upper portion is coupled to the lower portion via a mechanical bearing hinge on a first shell side. The upper portion defines a first upper slot and a second upper slot, and the lower portion defines a first lower slot and a second lower slot. The periphery of the upper portion has a tongue and the periphery of the lower portion has a corresponding groove such that the tongue of the upper portion fits into the groove of the lower portion. The upper portion has an upper wing on the first shell side and a clasp on a second shell side. The lower portion has a lower wing on the first shell side and a clasp receptacle on the second shell side. The upper wing and the lower wing are graspable to separate the upper portion from the lower portion.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Inventor: Terrence Jay O'Neil
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Publication number: 20210268256Abstract: Provided is a connection member which is not limited by the material, the tube thickness, the tube diameter or the like of a suction tube and a discharge tube to be connected to a pump, and can eliminate troubles in the tube attachment. A connection member includes: a pump attachment part; a tube connecting part; and a flow passage defining part. At least a portion of each of the suction passage section and the discharge passage section of the flow passage defining part includes membranes deformable due to pressures of the liquid flowing in the suction passage section and the discharge passage section. The flow passage defining part has a shape allowing the flow passage defining part to be attached in an arrangement that the membranes face sensors for detecting a flow state of the liquid flowing in the suction passage section and the discharge passage section by deformation of the membranes.Type: ApplicationFiled: August 28, 2019Publication date: September 2, 2021Inventors: Masayuki URUMA, Kazuki ISHIBASHI
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Publication number: 20210268257Abstract: An end cap according to a disclosed embodiment is connected to a downstream side of a flow path of a medical liquid injection apparatus and is configured such that a priming liquid is introduced into the end cap. The end cap includes: a refraction part formed of a transparent material having a refractive index (nr) greater than 1 and including a first surface and a second surface forming an internal angle smaller than 90 degrees; and a indication part disposed to be spaced apart from the second surface. The end cap forms a passage in which the introduced priming liquid is movable, and a part of the passage is located between the second surface and the indication part.Type: ApplicationFiled: July 26, 2019Publication date: September 2, 2021Inventor: Yong Hyun Kim
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Publication number: 20210268258Abstract: Needleless connectors are described herein. A needleless connector includes a body, a valve element at least partially disposed within the body, and a base. The valve element includes a cylindrical portion having an outwardly extending flange at a distal end. The flange has a bottom surface with an outer area and an inner area. The base includes a rim having a top surface that is in contact with an outer area of the flange of the valve element, the rim defining a recess with a bottom surface separated from the top surface of the rim, and at least one support member having a top surface spaced apart from the top surface of the rim and configured to resist deformation of the flange toward the recess.Type: ApplicationFiled: May 18, 2021Publication date: September 2, 2021Inventors: Jonathan YEH, Chrisopher J. Zollinger, George Michel Mansour, Matthew Quach