Patents Issued in January 6, 2022
  • Publication number: 20220000051
    Abstract: Plant treatment systems and methods are presented.
    Type: Application
    Filed: November 7, 2018
    Publication date: January 6, 2022
    Inventor: Iddo GELTNER
  • Publication number: 20220000052
    Abstract: Provided herein is a genetic determinant for potato late blight resistance caused by the plant pathogen Phytophtora infestans, in potato, Solanum tuberosum L. Specifically, disclosed herein are Solanum tuberosum plants having a genetic determinant providing qualitative resistance against Phytophtora infestans which genetic determinant is located in the distal part of chromosome 12 of Solanum tuberosum between positions 60.1 and 67.2. Mbp and which genetic determinant is obtainable from a Solanum tuberosum plant with deposit No. NCIMB 43225.
    Type: Application
    Filed: November 11, 2019
    Publication date: January 6, 2022
    Inventors: Cornelis Anthonius Schuit, Martinus Jacobus Theodorus Klaver, Marie Anne Sophie Jeanne Elisabeth Hardy, Dora Lisa Moita E Coelho, Albertus Johannes Maria Schrijver
  • Publication number: 20220000053
    Abstract: The invention relates to improved Brassica species, including Brassica juncea, improved oil and meal from Brassica juncea, methods for generation of such improved Brassica species, and methods for selection of Brassica lines. Further embodiments relate to seeds of Brassica juncea comprising an endogenous oil having increased oleic acid content and decreased linolenic acid content relative to presently existing commercial cultivars of Brassica juncea, seeds of Brassica juncea having traits for increased oleic acid content and decreased linolenic acid content in seed oil stably incorporated therein, and one or more generations of progeny plants produced from said seeds.
    Type: Application
    Filed: May 10, 2021
    Publication date: January 6, 2022
    Inventors: Van Leonard Ripley, Steven A. Thompson, Zoë Christina Ehlert
  • Publication number: 20220000054
    Abstract: The present disclosure provides lettuce plants exhibiting resistance to downy mildew. Such plants may comprise novel introgressed genomic regions associated with disease resistance from L. virosa. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.
    Type: Application
    Filed: July 8, 2021
    Publication date: January 6, 2022
    Inventors: Bart Willem Brugmans, Gerard N. Koorevaar, Hieronymus J.M. van der Laan, Rosa I. Weber
  • Publication number: 20220000055
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 6, 2022
    Applicant: University of Kentucky Research Foundation
    Inventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
  • Publication number: 20220000056
    Abstract: The present disclosure relates generally to new cannabis plants, including parts, extracts and uses thereof, comprising a cannabinoid profile enriched for total THC (i.e., ?-9-tetrahydrocannabinol (THC) and ?-9-tetrahydrocannabinolic acid (THCA), total CBG (i.e., cannabigerol (CBG) and cannabigerolic acid (CBGA)), and total THCV (i.e., tetrahydrocannabivarin (THCV) and tetrahydrocannabivarinic acid (THCVA)).
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Inventors: Aaron Christopher Elkins, Simone Jane Rochfort, Noel Cogan, German Carlos Spangenberg
  • Publication number: 20220000057
    Abstract: Defoliation of maize plants, based on percent seed moisture, has advantageous outcomes including greater number of seeds per pound; increased volume or proportion of saleable seed per field and per female acre; decreased discard of seed due to commercially undesirable size or shape; lower moisture content of seed at harvest; earlier harvest date; less fuel and time expended in drying seed for storage; improved performance in laboratory tests for germination at cold temperatures; improved seed treatment efficacy; improved emergence under stress in field conditions; improved plantability in mechanical systems; more uniform stand; fewer runt plants and improved grain yield.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 6, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: EDUARDO MIHURA, SCOTT NELSON, IMAD N SAAB, ADDA CECILIA SAYERS, AARON SCHWARTE
  • Publication number: 20220000058
    Abstract: A novel soybean variety, designated 5PNBY64 is provided. Also provided are the seeds of soybean variety 5PNBY64, cells from soybean variety 5PNBY64, plants of soybean 5PNBY64, and plant parts of soybean variety 5PNBY64. Methods provided include producing a soybean plant by crossing soybean variety 5PNBY64 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PNBY64, methods for producing other soybean varieties or plant parts derived from soybean variety 5PNBY64, and methods of characterizing soybean variety 5PNBY64. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PNBY64 are further provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: January 6, 2022
    Applicant: AGRIGENETICS, INC.
    Inventors: BRADLEY J. FORESMAN, DENNIS SCHULTZE
  • Publication number: 20220000059
    Abstract: A novel soybean variety, designated 5PAZG19 is provided. Also provided are the seeds of soybean variety 5PAZG19, cells from soybean variety 5PAZG19, plants of soybean 5PAZG19, and plant parts of soybean variety 5PAZG19. Methods provided include producing a soybean plant by crossing soybean variety 5PAZG19 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PAZG19, methods for producing other soybean varieties or plant parts derived from soybean variety 5PAZG19, and methods of characterizing soybean variety 5PAZG19. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PAZG19 are further provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: January 6, 2022
    Applicant: AGRIGENETICS, INC.
    Inventors: WILLIAM M. CAMPBELL, STEVE DAMON
  • Publication number: 20220000060
    Abstract: A novel soybean variety, designated 5PKHR80 is provided. Also provided are the seeds of soybean variety 5PKHR80, cells from soybean variety 5PKHR80, plants of soybean 5PKHR80, and plant parts of soybean variety 5PKHR80. Methods provided include producing a soybean plant by crossing soybean variety 5PKHR80 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PKHR80, methods for producing other soybean varieties or plant parts derived from soybean variety 5PKHR80, and methods of characterizing soybean variety 5PKHR80. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PKHR80 are further provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: January 6, 2022
    Applicant: AGRIGENETICS, INC.
    Inventors: EVELYN ORTIZ-PEREZ, HUNT B. WILEY
  • Publication number: 20220000061
    Abstract: A novel soybean variety, designated 5PLDE25 is provided. Also provided are the seeds of soybean variety 5PLDE25, cells from soybean variety 5PLDE25, plants of soybean 5PLDE25, and plant parts of soybean variety 5PLDE25. Methods provided include producing a soybean plant by crossing soybean variety 5PLDE25 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PLDE25, methods for producing other soybean varieties or plant parts derived from soybean variety 5PLDE25, and methods of characterizing soybean variety 5PLDE25. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PLDE25 are further provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: January 6, 2022
    Applicant: AGRIGENETICS, INC.
    Inventors: MARK F. HAYES, JASON DAVID NEUS
  • Publication number: 20220000062
    Abstract: The present invention is in the field of soybean variety EC1661152, EC1661470, EC1661291, AND/OR EC1661249 breeding and development. The present invention particularly relates to the soybean variety EC1661152, EC1661470, EC1661291, AND/OR EC1661249 and its seed, cells, germplasm, plant parts, and progeny, and methods of using EC1661152, EC1661470, EC1661291, AND/OR EC1661249 in a breeding program.
    Type: Application
    Filed: September 15, 2021
    Publication date: January 6, 2022
    Inventor: Daniela Dvorjak
  • Publication number: 20220000063
    Abstract: The present disclosure provides alfalfa plants exhibiting broad spectrum resistance to Race 1, Race 2, and Race 5 anthracnose. Such plants may comprise novel introgressed genomic regions associated with disease resistance from Race 1, Race 2, and Race 5 anthracnose. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided. Also provided are alfalfa varieties designated as C0416C4164 and H0415C4114. Provided by the invention are the seeds, plants and derivatives of alfalfa varieties C0416C4164 and H0415C4114. Also provided by the invention are tissue cultures of alfalfa varieties C0416C4164 and H0415C4114, and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing alfalfa variety C0416C4164 or H0415C4114 with itself or another alfalfa variety and plants produced by such methods.
    Type: Application
    Filed: June 21, 2021
    Publication date: January 6, 2022
    Inventors: Charles A. Rodgers, Mark H. McCaslin, David D. Witte, Julie Chiu-Lee Ho, John Nicholas Cameron
  • Publication number: 20220000064
    Abstract: A control arrangement and a control module for a milking position for milking a dairy animal includes a casing forming an inner space enclosing a printed circuit board incorporating a control system for controlling and supervising at least some functions of the milking position. A communication area is provided on a front side of the printed circuit board and communicates with the control system. The casing includes an inner front plate. The front side of the printed circuit board is attached to a rear side of the inner front plate by a transparent adhering substance so that a part of the printed circuit board projects from the rear side of the inner front plate. The inner front plate permits access to the communication area. The part of the printed circuit board is embedded in a block of plastic material.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Inventors: Emil KARBING, Anders KVIST, Ingvar SJÖKVIST
  • Publication number: 20220000065
    Abstract: A kennel comprising: (a) a feeding system including: (i) one or more water bowls; (ii) one or more water storage in communication with the one or more water bowls; (iii) one or more food bowls; and (iv) one or more food storage in communication with the one or more food bowls; (b) a communication system including: (i) one or more cameras; (ii) one or more speakers; (iii) one or more microphones; or (iv) a combination of (i), (ii), and (iii); (c) an entry system including: a cleaning system; and (d) a remote device including an application that is in communication with the kennel so that a user can control the feeding system, the communication system, the entry system, or a combination thereof.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 6, 2022
    Inventor: Bryanna Bender
  • Publication number: 20220000066
    Abstract: A dog kennel that provides a partition wall to separate a kennel into at least two compartments. One compartment is intended to be the living area of the dog and a second compartment is intended to house the food and water for the dog. The partition wall provides an opening for the dog to have access to her or his food and water, while also restricting the dog from entering the food and water compartment. An additional storage compartment may also be provided above the food and water compartment.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 6, 2022
    Inventor: Tazwa Brown
  • Publication number: 20220000067
    Abstract: A pet feeder tray having an elevated platform. The platform having multiple apertures for removable receiving bowls. The pet feeder tray having four legs at corners for elevating the platform to the desired height. Bowls adapted to receive the feed of a pet can be removably received within the apertures.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Inventor: Robert Leon Sapp, JR.
  • Publication number: 20220000068
    Abstract: A monitoring and intervening assembly for rearing premises includes: a movable monitoring unit equipped with a unit for monitoring the rearing premises and the animals resident therein, the geographic coordinates of the unit in the premises being determinable with respect to an origin, at least one movable intervening module able to be driven and controlled by the monitoring unit, the intervening module, at rest, being installed in a storage area, the monitoring unit and the intervening module both including interacting mechanical coupling for linking one to the other, the coupling being lockable and unlockable, the monitoring unit being able to continuously monitor the premises and the animals, without however being coupled to the or one of the intervening modules.
    Type: Application
    Filed: November 13, 2019
    Publication date: January 6, 2022
    Inventor: Christian DUSSAU
  • Publication number: 20220000069
    Abstract: A water fountain for the pets may include a water tray, a water bottle and a bottle cap. The water fountain include two supporting wings, a connecting piece and a hose, the two supporting wings are hinged with two sides of the water tray respectively, a first end of the connecting piece is in connection with the water bottle and in communication with an inner part of the water bottle, a second end of the connecting piece is in connection with the bottle cap and in communication with an inner part of the bottle cap. a first end of the hose is in connection with the bottle cap and in communication with the inner part of the bottle cap, a second end of the hose is arranged inside the water tray. The water fountain not only prevent the water tray from being turned over, but also is convenient to carry.
    Type: Application
    Filed: September 16, 2021
    Publication date: January 6, 2022
    Inventors: Tianle Yang, Yibao Zeng
  • Publication number: 20220000070
    Abstract: Systems and techniques are described for pet monitoring during unattended delivery. In some implementations, a monitoring system monitors a property includes sensors located throughout the property and generates sensor data. A monitor control unit receives a first indication that a resident of the property will be receiving a delivery during a delivery time. Based on the sensor data and during the delivery time, the monitor control unit determines that a pet, that resides at the property, has been restrained. The monitor control unit provides, to a delivery person, a second indication that the pet at the property has been restrained.
    Type: Application
    Filed: September 17, 2021
    Publication date: January 6, 2022
    Inventors: Jeffrey A. Bedell, Abraham Joseph Kinney, Jace Jawn Bauer, Robert Nathan Picardi, Matthew Daniel Correnti
  • Publication number: 20220000071
    Abstract: An automatic dog back scratcher system that scratches a dog, comprising a frame assembly; a housing covering the frame assembly; a movable arm assembly supported by the frame assembly and including a movable finger assembly; a treat dispenser assembly; a camera; a motion sensor; a controller configured to sense motion of an object via the motion sensor, determine the object in motion is a dog via the camera, dispense a treat via the treat dispenser assembly to attract the dog to a location adjacent to the automatic dog back scratcher system, and operate the movable arm assembly to move the arm adjacent to the dog and scratch the dog with the movable finger assembly.
    Type: Application
    Filed: June 23, 2021
    Publication date: January 6, 2022
    Inventor: Cassidy Matwiyoff
  • Publication number: 20220000072
    Abstract: A pet cleaning glove includes a glove body, a scrubbing arrangement, a water supply arrangement and a cleaning supply arrangement. The glove body, which is made of waterproof material, has at least a finger pocket, a thumb pocket, and a palm pocket, and defines a palmar side and a dorsal side. The scrubbing arrangement is provided at the palmar side of the finger pocket and the palmar side of the thumb pocket only. The water supply arrangement includes an inlet port adapted for connecting to a water source and at least an outlet port formed at the palmar side of the finger pocket for dispensing water from the water source. The cleaning supply arrangement is provided at the palmar side of the palm pocket for receiving a cleaning agent, wherein the glove body is folded at the palm pocket thereof for squeezing out the cleaning agent.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 6, 2022
    Inventor: Brandon Cheung
  • Publication number: 20220000073
    Abstract: An edible pet chew includes a member of Bully Stick Analogue formed from a composition material may be with at least 20% plant ingredient imitating existing traditional bully stick products, serving as an alternative to it. The imitation may include the structure, and/or appearance, and/or shape, and/or size, and/or color, and/or texture, and/or flavor, and/or durability, and/or palatability of traditional bully stick. It is an extruded stick processed by an extruder or a stick formed by injection molding machine.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 6, 2022
    Inventor: Guangqiang Xu
  • Publication number: 20220000074
    Abstract: Disclosed is a mounting base (300) for attaching a portable electronic device (402) to a collar apparatus (400). Mounting base (300) includes a frame (102) and a latch (200). Latch (200) is moveable between a latched position and an unlatched position. Latch (200) includes an actuator (206) with a button (208) that may be depressed by a user to manually move latch (200) between the latched and unlatched positions. A portable electronic device (402) includes an insertion portion (410) that is received in a receiving aperture (108) in the frame (102). Once the insertion portion (410) is inserted, the device (402) may be rotated manually to engage latch (200). During rotation, a lock stub (216) on latch (200) engages a corresponding feature on insertion portion (410), thereby preventing counter-rotation of device (402). Additionally, one or more tabs (120) on frame (102) interfere with corresponding structure on insertion portion (410) to secure device (402) onto mounting base (300).
    Type: Application
    Filed: November 18, 2019
    Publication date: January 6, 2022
    Applicant: MARS, INCORPORATED
    Inventors: Robert W. Mott, JR., Kyu Sang Lee, Stanley John Withouski, IV
  • Publication number: 20220000075
    Abstract: The invention presents a harness assembly for lifting and supporting an animal in mobility. The assembly comprises a front and rear harness sections releasably attached by a lifting leash. Both the front and rear harness sections can be used independently. Both the front and rear harness sections are comprised of upper and lower sections releasably attached to one another. The rear harness section lifts the animal from both the hips and waist resulting in less stress than other devices.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 6, 2022
    Inventors: Patrick Hoffman, David King, Thomas Murphy
  • Publication number: 20220000076
    Abstract: A system comprising a first transmitter for transmitting a first signal at a first frequency and a second transmitter for transmitting a second signal at a second frequency. The system includes a collar unit comprising a filter for receiving a combined signal, wherein the combined signal comprises the first signal and the second signal, wherein the filter includes a first antenna for detecting the first signal and a second antenna for detecting the second signal. The collar unit includes at least one signal analysis component configured to analyze the first signal and the second signal. The collar unit is configured to instruct a stimulus delivery unit to deliver a stimulus to the animal when the first signal voltage falls below a first value and the second signal voltage exceeds a second value.
    Type: Application
    Filed: July 4, 2020
    Publication date: January 6, 2022
    Inventors: Richard Seltzer, Duane A. Gerig
  • Publication number: 20220000077
    Abstract: An arrangement for measuring the body temperature of a bird comprises: (a) an enclosure having at least one aperture configured for receiving a bird's head thereinto at least in a partial manner; (b) at least one receptacle mounted within the enclosure; at least one receptacle accommodating an attractor; (c) at least one remote sensing instrument configured for acquire thermal reading and calculating bird's temperatures. The remote sensor instrument and the receptacle accommodating the attractor are mutually disposed such that at least the bird's head is within a field of view of the remote sensor instrument.
    Type: Application
    Filed: November 4, 2019
    Publication date: January 6, 2022
    Inventors: Ilan HALACHMI, Shelly DRUYAN, Natan Meir BARCHILON, Shlomo YHAHAV
  • Publication number: 20220000078
    Abstract: An aquaculture system includes a pen configured to be disposed in a body of water and configured to at least temporarily store aquatic animals during development. A control system is configured to receive electric power from a power source and is configured to provide electric power to a pumping mechanism coupled to the pen such that the pumping mechanism provides a flow of water through the pen. A set of buoyancy tanks are coupled to the pen. A portion of the control system is in fluid communication with the set of buoyancy tanks and is configured to adjust a volume of fluid in at least one buoyancy tank to move the pen from a first position in which the pen is partially submerged in the body of water to a second position in which the pen is fully submerged in the body of water.
    Type: Application
    Filed: February 10, 2021
    Publication date: January 6, 2022
    Applicant: Running Tide Technologies, Inc.
    Inventors: Matthew Jordan ODLIN, Nate MERRILL, Stephen ZADESKY
  • Publication number: 20220000079
    Abstract: A method of monocular depth estimation includes receiving a plurality of monocular images corresponding to images of fish within a marine enclosure and further receiving acoustic data synchronized in time relative to the plurality of images. The plurality of images and the acoustic data are provided to a convolutional neural network (CNN) for training a monocular depth model. The monocular depth model is trained to generate, based on the received plurality of monocular images and the acoustic data, a distance-from-feeder estimate of a vertical biomass center of fish within the marine enclosure.
    Type: Application
    Filed: July 6, 2020
    Publication date: January 6, 2022
    Inventors: Ming Chen, Dmitry Kozachenok, Allen Torng
  • Publication number: 20220000080
    Abstract: The invention relates to a solution that enables optimized regulation of feeding rates in aquaculture systems. The invention involves a feed detector shaped as a pipe segment that can be directly installed as a pipe socket in an outlet pipe of an aquaculture system. The feed detector comprises a pipe segment, radiation means and detection means.
    Type: Application
    Filed: November 1, 2019
    Publication date: January 6, 2022
    Inventor: Ragnvald Inge Otterlei
  • Publication number: 20220000081
    Abstract: Embodiments of the present disclosure describe a raceway comprising a sloped base with an apex, a divider extending upward from the apex, two side walls, each opposing and parallel to the divider sufficient to form two elongated channels on the sloped base; and at least two tapered ends in fluid communication with the channels, each tapered end including an end wall, a pit, and a sloped floor extending from the sloped base to the end wall or pit.
    Type: Application
    Filed: September 16, 2021
    Publication date: January 6, 2022
    Inventor: Robert H. Gervais
  • Publication number: 20220000082
    Abstract: L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates for treatment, amelioration and/or prevention of protein aggregation/tangles/plaques and diseases associated with protein aggregation/tangles/plaques. In particular, treatments and uses for L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates include Alzheimer's disease (AD), Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington disease (HD).
    Type: Application
    Filed: July 12, 2021
    Publication date: January 6, 2022
    Inventors: Paul Alan COX, Sandra Anne BANACK, Deborah C. MASH
  • Publication number: 20220000083
    Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.
    Type: Application
    Filed: September 14, 2021
    Publication date: January 6, 2022
    Applicant: Alector LLC
    Inventors: Arnon ROSENTHAL, Seung-Joo LEE
  • Publication number: 20220000084
    Abstract: A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
    Type: Application
    Filed: June 9, 2021
    Publication date: January 6, 2022
    Inventors: Sean Stevens, Andrew J. Murphy, Richard Flavell, Elizabeth Eynon, Jorge Galan, Tim Willinger, Markus Manz, Anthony Rongvaux, George D. Yancopoulos
  • Publication number: 20220000085
    Abstract: The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses.
    Type: Application
    Filed: July 6, 2021
    Publication date: January 6, 2022
    Inventors: Glenn Friedrich, E-Chiang Lee, Jasper Clube, Nicholas England
  • Publication number: 20220000086
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.
    Type: Application
    Filed: September 23, 2021
    Publication date: January 6, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • Publication number: 20220000087
    Abstract: A fishing lure having a lure body with a first portion and a second portion. The lure has a rail extending from the first portion of the lure body to the second portion of the lure body. The rail has a first portion and a second portion. An attachment member is adapted to be combined with the rail and move between the first portion of the rail and the second portion of the rail. In use, when line is being let out of the reel for jigging so there is no upward force on the lure, the attachment member moves toward the front portion of the rail to allow the lure to descend quickly in a downward facing orientation through the water column to a desired depth. Then, upon application of some upward force on the line, the attachment member moves rearward along the rail to the second portion of the rail causing the lure to transition to a horizontal presentation.
    Type: Application
    Filed: July 6, 2020
    Publication date: January 6, 2022
    Applicant: Salmo Sp. z o.o.
    Inventor: Piotr Piskorski
  • Publication number: 20220000088
    Abstract: A method for securing a line guide to a fishing rod blank includes the steps of positioning a line guide having a guide foot along a rod blank, and wrapping a wrap having a substrate and an adhesive layer around the rod blank and the guide foot to secure the line guide to the rod blank.
    Type: Application
    Filed: December 18, 2020
    Publication date: January 6, 2022
    Inventor: Robert Penicka
  • Publication number: 20220000089
    Abstract: A universal tip top for a rod blank includes a leg member defining a channel for receiving a distal end of a rod blank, a frame connected to the leg member, and a ring forming a line guide supported by the frame. The channel has a longitudinal opening configured to facilitate attachment of the universal tip top to rod blanks of different diameters.
    Type: Application
    Filed: December 21, 2020
    Publication date: January 6, 2022
    Inventors: Robert Penicka, Scott Whitmore
  • Publication number: 20220000090
    Abstract: A fishing rod case composed of impact resistant material which covers the central portion and tip of the shaft of the fishing rod while leaving the handle and reel exposed. The case has two sections connected by a hinge and a closing mechanism which removably joins the two sections together when the case is in a closed position. The two sections each have a rod enclosing cutout which are joined to create an opening that encloses the rod when the case is closed. The circular opening is larger than the shaft of the rod, but smaller than the guides attached to the rod. Since the guides cannot pass through the opening created by joining the two rod enclosing cutouts the case is retained in place when it comes into contact with one of the guides attached to the shaft and is prevented from sliding off the rod.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 6, 2022
    Inventor: Edward Pierson
  • Publication number: 20220000091
    Abstract: A horseshoe nail for nailing a horseshoe to a hoof. The horseshoe nail is made from steel with a carbon weight percentage between 0.18 and 0.25. The horseshoe nail contains a shank with a tip at one end and a widened head at the other end. The head is at least hardened over a part of its length from its free end. The shank is not hardened over its entire or almost entire length from the tip.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 6, 2022
    Applicant: Kerckhaert Hoefijzerfabriek B.V.
    Inventor: Michiel Petrus M. Kerckhaert
  • Publication number: 20220000092
    Abstract: The invention refers to an insect trap consisting of a housing (1) in which there is a power supply system (2) and an electrical circuit board (3). The insect trap has a multi-layer mesh (4), in which an electric field of e.g. 2500 V is developed, thereby killing the insects. It may also have a lamp (7) to attract insects and a tray (8) at the bottom of the trap to collect the killed insects. The use of a screen (6) under the trap covers the remaining space of the aperture, allowing tenants to pass through.
    Type: Application
    Filed: November 5, 2019
    Publication date: January 6, 2022
    Inventor: Dimitrios ASLANIS
  • Publication number: 20220000093
    Abstract: A product applicator assembly including a housing having a first end and a second end; a dispensing force; a dispensing device operatively attached to the dispensing force; at least one power source; a dispensing switch operatively attached to the dispensing force; a data operator electrically connected to an electrical power source. Also provided is a bait applicator and a method of using the applicator to apply bait.
    Type: Application
    Filed: December 11, 2019
    Publication date: January 6, 2022
    Inventors: Alexander KO, Byron REID, David A. CLEMENS, Wilson Christopher LAMB, Michelle H. DEMERS, Paul STAPLETON, Spencer MOUGEY
  • Publication number: 20220000094
    Abstract: This application provides methods, compositions, and kits for use blood group determination and the preparation of improved red blood cell containing reagents for use in blood typing of blood prior to its use in transfusion medicine.
    Type: Application
    Filed: November 18, 2019
    Publication date: January 6, 2022
    Applicant: Hemanext Inc.
    Inventor: Tatsuro Yoshida
  • Publication number: 20220000095
    Abstract: A novel erythrocyte (red blood cell) membrane coating derived from human red blood cells and the methods of preparation and use thereof are disclosed. The erythrocyte membrane coating may be developed on a piezoelectric sensor coated with poly-L-lysine.
    Type: Application
    Filed: July 2, 2021
    Publication date: January 6, 2022
    Inventors: Peng YI, Tanaz ISLAM
  • Publication number: 20220000096
    Abstract: There is provided a technique of, when an organ is preserved outside a body while being perfused with a liquid, ensuring the flow rate of the liquid flowing in the organ while suppressing a rise in pressure in the liquid. An organ preservation system includes an organ container, an organ holder, a liquid supply tube, a drainage tube, and an atmospheric pressure regulator. The organ container is capable of having therein an organ preservation space that is a confined space. The organ holder holds the organ in the organ preservation space. The liquid supply tube supplies a liquid to the organ held by the organ holder. The drainage tube discharges a liquid from the organ held by the organ holder. The atmospheric pressure regulator regulates atmospheric pressure in the organ preservation space. By regulating atmospheric pressure in the organ preservation space, it is possible to adjust a pressure in the liquid flowing in the organ.
    Type: Application
    Filed: October 16, 2019
    Publication date: January 6, 2022
    Inventors: Eiji Kobayashi, Syuhei YOSHIMOTO, Shinji TORAI
  • Publication number: 20220000097
    Abstract: This disclosure relates to a system for freezing, transporting, storing and thawing aqueous solutions of biological materials, in particular those used in chemical and pharmaceutical processes. In particular, this disclosure relates to ice-crust attenuator devices to prevent ice-crust formation at the top of the solution. The ice-crust attenuator devices (10) have an internal cavity comprising a phase change material to improve thermal insulation. The ice-crust attenuator device may comprise an internal wall made of a moldable material configured to attain a good thermal contact between the ice-crust attenuator device and the outer surface of the container. In another embodiment, the ice-crust attenuator device is configured to be placed in a refrigerated cavity and in contact with the upper surface of a moldable container, to keep the top of the container under insulated conditions. The ice-crust attenuator device may be connected to a holder to accommodate the moldable container.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 6, 2022
    Inventors: Rui DE BRITO ESTRELA, Andreia Filipa SILVESTRE DUARTE, Pedro Gil SENA REGO
  • Publication number: 20220000098
    Abstract: A liquid nitrogen tank includes a tank, a storage rack and a drive component. The tank includes a tank cover, a tank body, a vacuum cavity layer and a heat-insulating cavity layer. The tank cover is disposed to cover on the tank body. An access door is provided on the tank body. A storage cavity is provided in the tank body. The heat-insulating cavity layer is provided on a periphery of the storage cavity. The vacuum cavity layer is provided on a periphery of the heat-insulating cavity layer. The storage rack is provided in the storage cavity. A plurality of cryopreservation tube racks are stored in the storage rack. The drive component can drive the storage rack to rotate and move up and down in the storage cavity, and can drive the plurality of cryopreservation tube racks to move to a position corresponding to the access door.
    Type: Application
    Filed: January 8, 2019
    Publication date: January 6, 2022
    Applicant: SHANGHAI ORIGINCELL BIOLOGICAL CRYO EQUIPMENT CO., LTD.
    Inventors: Jianguo QU, Lingling LIU, Huoming QIAO, Jianxin WANG
  • Publication number: 20220000099
    Abstract: Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. Gas passing into and out of the organ may be conditioned to prolong tissue viability.
    Type: Application
    Filed: September 7, 2021
    Publication date: January 6, 2022
    Inventors: Adam Collette, Melanie Jessel, Lisa Maria Anderson
  • Publication number: 20220000100
    Abstract: A concentrated adjuvant composition comprises an incompletely hydrated water-soluble polymer suspended in a liquid medium, a suspension agent, a surfactant, optionally, a glycol, glycol derivative, glycerol or glycerol derivative, and a water conditioning component.
    Type: Application
    Filed: June 10, 2021
    Publication date: January 6, 2022
    Applicant: RHODIA OPERATIONS
    Inventors: Hong Liu, Chunhui Bao, Subramanian Kesavan, Charles Manzi-Nshuti