Abstract: The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to MAVS compositions and their use in cancer therapeutics that may be used to treat various cancers alone or in combination with other anti-cancer therapeutic agents.

Abstract: A functional gadolinium contrast agent comprising a gadolinium cation and a ligand secured to the gadolinium cation is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing gadolinium contrast agents from a patient is disclosed, the method comprising providing a gadolinium contrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the gadolinium contrast agent to the patient; conducting a magnetic resonance imaging procedure; and sequestering the gadolinium contrast agent on the capture substrate. A system for removing gadolinium contrast agents is also disclosed.

Abstract: An object of the invention is to provide an 11C-labeled catechol derivative having sufficient radioactivity to obtain an imaging image by a PET apparatus, a PET probe of a phosphorylated tau aggregation inhibitor using the same, and a method for producing them. The 11C-labeled catechol derivative of the present invention is represented by the following general formula (a) (wherein R is a substituent having an isopropylamino group, and the carbon at the 2-position of the isopropylamino group is labeled with 11C).

Abstract: The present invention provides compositions and methods for detecting GluA1, as a subunit protein and/or as a GluA1-containing, GluA2-lacking AMPAR complex. The invention further provides composition and methods for detecting and/or diagnosing PTSD. The invention further relates to compositions that can be detected using radiological imaging techniques, and processes for performing such imaging techniques using the compositions, to identify elevated GluA1 expression or activity in a subject, which is a biological marker of PTSD.

Abstract: The invention relates to the processing of fluid biological media, especially of culture media or cell- or virus suspensions, potentially containing active pathogens, with the aim of inactivating these pathogens and/or modifying ingredients in these biological media by thermal or radiological treatment.

Abstract: Provided is a decontamination apparatus including a base, and a source that emits UVC light at a suitable intensity to at least partially decontaminate a target object and render the target object pathogen reduced. An adjustable support is coupled to the base and includes an adjustment mechanism that can be manipulated to adjust a position of the source relative to the base. A controller is operatively connected to the source to control emission of the UVC light and establish at least one of a suitable duration of a decontamination process and a suitable intensity of UVC light to render the target object pathogen reduced.

Abstract: A multilayer produce packaging film includes a first layer and a chlorine dioxide-producing layer. The chlorine dioxide-producing layer includes a polymer composition and a plurality of chlorite ions. The chlorine dioxide-producing layer is substantially free of an energy-activated catalyst and is substantially free of an acid-releasing compound. However, the film is capable of generating chlorine dioxide when exposed to UV light and moisture.

Abstract: The present invention is generally related to a device and method for sanitizing a medical instrument with ozone, in particular the invention relates to a system, method and a device for sanitizing a continuous positive airway pressure (CPAP) device. The device has an ozone compartment, an ozone operating system and one or more ozone distribution lines that distribute ozone to a continuous positive airway pressure device. The device may further include a heater adapter unit to connect heating systems in CPAP devices while distributing ozone to sanitize the CPAP device in accordance with the present invention.

Abstract: System and method to reduce risk of patient infections (HAI), using operating rooms (chambers) equipped with suitable automatic airborne sterilizing agent generators, sensors, mechanisms, automatic air control devices, and laminar flow devices. After suitable safety checks, the system isolates the interior air from external air, and activates an air phase anti-microbial agent generator, filling the room with an air-phase anti-microbial agent. After sterilization, the invention deactivates the generator then restores the connection to outside sterilized air. The chamber also comprises an intelligent platform comprising video cameras, and computer vision systems configured to identify humans and medical supplies, read optical tags, and correlate recognized objects with RFID tag data.

Abstract: An essential oil reflux-type atomizer comprising the following structures: a chassis, housing, atomization chamber, gas pump, gas tube, gas nozzle, oil nozzle, and filter atomization mechanism. Oil and gas flow together at the gas and oil nozzles to disperse and atomize the oil in the gas flow.

Abstract: Disclosed herein is a forced irradiated air shielding mechanism that is an effective protective measure against Covid-19. The UV-C irradiated forced air flow face shield described herein is compact enough to be camouflaged under a cap. In this work it is mathematically proven that the described UV-C irradiated forced air flow face shield by itself provides more effective protection against the Covid-19 or similar airborne pathogens. The shield can be enabled using a mercury discharge tube or light emitting diode (LED) irradiator. Computational fluid dynamics is presented to show that positive irradiated air pressure ensures that the only air breathed by the wearer is irradiated. Also presented is a face shield testing apparatus.

Abstract: The present invention relates to a hydrophilic foam material, which is of particular use in wound treatment, and to a method for producing said hydrophilic foam material. The hydrophilic foam material has nucleating particles, wherein at least 85% of all foam cells in said foam material have an average cell size of 0.01 mm2 or less.

Abstract: Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Abstract: The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as bacterium.

Abstract: The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation.

Abstract: A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.

Abstract: To provide a concentration calculating module configured to measure the concentrations of two constituents simultaneously with higher accuracy. The concentration measuring module includes a light source configured to emit light into a housing; a first light receiving unit configured to have sensitivity to a wavelength of output light of the light source and receive light radiated from inside the housing; and a second light receiving unit configured to have sensitivity to a longer wavelength than the first light receiving unit and receive light radiated from inside the housing.

Abstract: A peritoneal dialysis machine has at least one mount for fixing one or more sections of a hose set for conducting a dialysis solution from and/or to a patient. A first pivot axle is provided about which the mount can be pivoted from a first position into a second position.

Abstract: A method of performing dialysis includes: recirculating a dialysis fluid from a patient or a dialyzer for at least two cycles, each cycle contacting the dialysis fluid first with a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; storing the recirculated dialysis fluid in a storage container; and transferring the dialysis fluid from the storage container to the patient or the dialyzer. In one example, the zirconium phosphate layer and the at least one of the urease layer, the zirconium oxide layer, or the carbon layer is provided by a sorbent cartridge.

Abstract: A peritoneal dialysis device includes a disposable tubing set that includes a fill line with a patient access connector at one end and a dialysis fluid receiving end opposite the patient access connector end. The device also includes a fill-side pressure measuring sensor attached at the fill end and forming a disposable component of the tubing set and a patient-side pressure measuring sensor located at the fluid receiving end. The patient-side and fill-side pressure measuring sensors are adapted for measuring pressure in the fill line at the respective ends thereof. The device also includes a controller configured to regulate a rate of flow in the fill line responsively to a signal from the at least the patient-side pressure measuring sensor.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: A filter material and a manufacturing method thereof are provided. The manufacturing method includes hydrophilizing the filter material by supercritical fluid processing technology, so as to filter out white blood cells in the blood.

Abstract: The present invention relates to a medical instrument for the targeted introduction of a substance into a body cavity and to a tool (1) therefor. According to the invention, the tool (1) has a shaft (2) with a lumen (6), on the distal end (1?) of which is situated a nozzle head (3) with at least two nozzles (4), wherein the nozzles (4) are spaced from each other at an angle of less than 180° and equally relative to a centre axis (M) of the shaft (2).

Abstract: A transport lock assembly for a medicament delivery device, wherein the transport lock assembly comprises a powerpack (30) having a locking member (50, 50?, 50?) configured to interact with a control member (60), which locking member (50, 50?, 50?) is movable, relative to the control member (60), from a first state in which the control member (60) is immobilized, to a second state in which the control member (60) is free to move; wherein the transport lock assembly further comprises a housing part (20) having a key member (22), such that assembly of the powerpack (30) with the housing part (20) causes the key member (22) to move the locking member (50, 50?, 50?) from the first state to the second state.

Abstract: Guided relay infusion systems and methods are provided. A guided relay infusion system may be a portion of an infusion pump that can simultaneously deliver a medical fluid from two syringes. When a first one of the syringes is running out of the medical fluid and a second one of the syringes is more full of the medical fluid than the first one of the syringes, guided relay messages are provided for a relay handoff from the first one of the syringes to the second one of the syringes that ensures a smooth continuous delivery of more of the medical fluid than the first one of the syringes holds.

Abstract: The present disclosure relates to a flexible container for an injection device including a flexible bag having an interior volume to be filled with a liquid medicament, an outlet located at a first end of the bag, and a contraction member connected to the bag to displace a second end of the bag located opposite to the first end towards the first end.

Abstract: A rotary drive for a medical device (10) includes a rotary motor (14) including a rotor (26). A rotary motion encoder (34) is connected to the rotor. The rotary motion encoder is configured to generate a number of encoder steps measuring a rotational distance of the rotor. At least one electronic processor (18) is programmed to determine at least one of a slippage value of the rotary motor measured during motor operation and a coasting value of the rotary motor measured after stopping motor operation based on comparison of an actual count of encoder steps and an expected count of encoder steps.

Abstract: A method and medical pump to perform a flushing procedure are provided. The medical pump is configured to execute the flushing procedure subsequent to an infusion procedure, the flushing procedure and infusion procedure lacking a specified relationship between each other until after performance of the infusion procedure. The method comprises performing an infusion procedure of a medicament with the medical pump and automatically querying in human detectable form whether to execute a flushing procedure in response to conclusion of the infusion procedure.

Abstract: Disclosed herein are systems and methods for safely switching between medicament delivery control algorithms for control of an ambulatory infusion pump or other medical device. Infusion pumps and/or remote control devices may be capable of operating different algorithms for delivery of medicament and provided herein are mechanisms for safely transitioning between algorithms.

Abstract: An automatic injection device including an injection syringe equipped with a syringe body and with a piston rod mounted movably in this syringe body so as to cover an injection stroke, a piston control member capable of changing between a configuration in which it is in engagement with the piston rod and a configuration in which it is disengaged from this piston rod, mechanism for moving the piston control member between its two configurations with respect to the piston rod. The mechanism for moving the control member between its two configurations includes a camway carried by a disengagement member and a cam carried by the control member. The disengagement member is movable with respect to the piston rod and the syringe body after the end of the injection stroke, in such a way as to cause the camway to interact with the cam.

Abstract: A drug delivery device for administering a drug is presented having a body adapted to retain a cartridge containing a drug, at least one electrical unit and a port for electrically contacting the electrical unit, an adapter for attaching an injection needle to the drug delivery device, a safety mechanism arranged to prevent contacting the electrical unit through the port whilst an injection needle is in fluid communication with the cartridge and arranged to prevent establishing a fluid communication between an injection needle and the cartridge whilst the port is configured to allow contacting the electrical unit.

Abstract: An injector for delivering medicament includes a first sleeve defining a longitudinal axis, a medicament container, and a locking tab. The medicament container is at least partially disposed within the first sleeve and configured for axial translation with respect to the first sleeve along the longitudinal axis. The medicament container includes a barrel, a needle mounted to a distal end of the barrel, a seal slidably mounted in the barrel, and a plunger rod. The locking tab extends through an aperture in the first sleeve and is in contact with or adjacent to a portion of the medicament container such that the locking tab restricts translation of the barrel with respect to the first sleeve along the longitudinal axis. The locking tab is configured to be movable to a second position in which the locking tab does not restrict translation of the barrel.

Abstract: The invention relates to an injection unit, preferably a pen-shaped injection unit, for administering or delivering a fluid product. The injection unit comprises a housing, an axially movable piston rod mounted in the housing in a non-rotatable manner, a delivery apparatus having a threaded nut that is able to move the piston rod in order to deliver product, a dosing device having a dosing sleeve, a rotary knob, a discharge button arranged coaxially on the dosing sleeve, and a receptacle for the product. The dosing device is connected to the delivery apparatus via a coupling mechanism, wherein the coupling mechanism includes of at least two coupling surfaces that each carry a toothing comprising teeth, wherein the coupling surfaces are used to generate an acoustic and/or tactile signal corresponding to the set or corrected dose of the product to be administered during the dosing operation or during correction of the dose.

Abstract: Disclosed is an injection device for injecting a hypodermic syringe along an injection direction defining an injection axis. The injection device comprises a housing for being positioned at a user's skin, and a movable element movably arranged relative to the housing between a retracted position and an injection position.

Abstract: A method includes protecting an entire length of a needle of a needle-based device in a first state of disuse thereof with a needle cap, encompassing, by a needle shield, the entire length of the needle and at least a partial length of the needle cap in the first state of disuse, and encompassing an entire protruding length of the needle cap outside the needle shield within a safety cap and securing the safety cap onto an outer surface of the needle shield such that the needle and the needle cap are completely protected and covered during the first state of disuse. Following removing the safety cap along with the needle cap from the needle shield, the method also includes retracting the needle shield to cause the needle to emerge out of the needle shield to prepare the needle-based device for a second state of use thereof.

Abstract: A delivery tool connectable with a syringe can be used to deliver a viscoelastic solution. The tool includes a first segment, a second segment and an inner lumen defined by the first and second segments. A distal portion extends from the second segment in a curved manner.

Abstract: This invention is a syringe having a tubular sleeve protector. The syringe has a barrel with an injection needle and a guide pin on an exterior surface of the barrel. The barrel and the injection needle are in an interior of a tubular sleeve has a spiral guide track on an interior wall. The guide pin fits in the spiral guide track and moves the barrel towards a bottom end of the tubular sleeve as the barrel is rotated, thereby extending the injection needle out of the tubular sleeve. A lateral guide track connects the spiral guide track to a vertical guide track. The guide pin moves from the bottom of the spiral guide track through the lateral guide track to the vertical guide track when the syringe barrel is further rotated. The injection needle is retracted into the interior of the tubular sleeve when the guide pin is moved into the vertical guide track and moved upwards in the vertical guide track towards a top end of the tubular sleeve.

Abstract: Spray dispenser for nasal drugs includes a non-pressurized bottle for storing medical fluids in particular of drugs and other sterile fluids, a mounting body mounted to the top of the bottle and an actuating body, wherein the bottle, the mounting body and the actuating body are aligned along a longitudinal axis, and wherein the actuating body is slideably attached to the mounting body along the longitudinal axis and movable between an actuating position and a non-actuating position, wherein the spray dispenser includes an applicator nozzle and an actuating section for moving the actuating body into the actuating position, characterized in that the applicator nozzle has a nozzle axis which is inclined with respect to the longitudinal axis, the applicator nozzle facing away from the actuating section.

Abstract: The invention relates to a nozzle for use in a device for administering a liquid medical formulation, to a method for producing the nozzle in the form of a microfluidic component and to a tool for producing microstructures of the microfluidic component. The nozzle is formed by a plastics plate with groove-like microstructures which are covered by a plastics cover on the longitudinal side in a fixed manner. The production method includes a moulding process in which a moulding tool is used, which moulding tool has complementary metal microstructures which have been produced from a semiconductor material in an electrodeposition process by means of a master component.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: An inhaler for inhalation of a formulation in powder form includes: a magazine which is rotatable and contains pre-dosed doses of the formulation in capsules, a housing which is substantially round or disc-shaped, the housing having a housing part in which the rotatable magazine is disposed, where the housing part is fixedly coupled to the rotatable magazine, and is removable from the housing in order to facilitate replacement of the magazine by inserting a new magazine.

Abstract: The present invention relates to a dispenser for dispensing a liquid, comprising: a reservoir for storing a liquid to be dispensed; a manually operative pump arrangement disposed at a first end region of the reservoir; a conduit extending from the pump arrangement to a second end region of the reservoir distal the first end region, the conduit configured for communicating reservoir contents from the second end region to the pump arrangement; a dispense conduit extending from the pump arrangement and comprising a dispense aperture at an end region thereof, the dispense aperture in liquid communication with the pump arrangement; and an open ended tube extending in a direction away from the pump arrangement and configured to surround the dispense conduit, wherein the open ended tube extends to a position such that the open end thereof is at least coterminous with an dispense aperture end of the dispense conduit and actuation of the pump arrangement causes transfer of reservoir contents from the reservoir to the

Abstract: A device and method for adjusting a tidal breath delivered to a patient. The device includes a moving frame which is configured to move over a stationary frame that is nested within the moving frame itself. Disposed between the moving frame and the stationary frame is a compressible bellows which delivers a tidal breath to the patient each time the moving frame is passed over the stationary frame. The specific volume of the tidal breath that is delivered may adjusted according to the estimated weight of the patient, thereby preventing over inflation of the patient's lungs while undergoing treatment. To adjust the tidal breath volume, the user quickly changes the relative position of a slide adjuster which dictates the range of possible movement between the moving frame and the stationary frame, thereby limiting the volume of air/oxygen which may be drawn into the bellows.

Abstract: An instrument for accessing and visualizing hollow organs is provided. The instrument includes a mouthpiece having a perforated mask and a sleeve having a generally cylindrical or ovoid shape extending from the perforated mask substantially perpendicularly thereto and defining a channel. The instrument further includes sucking means having a suction chamber or closed volume that is restrained to the mask on the side where the sleeve is formed. The suction chamber has a plurality of through openings adapted to allow fluid communication with a surrounding environment, an intake opening communicating with the suction chamber formed on the mask, wherein the through openings are formed on the skirt of a dome-shaped member which delimits the suction chamber.

Abstract: A mask with cushion that has an outer film is disclosed. The film may be self-skinning or a film formed about or glued to the cushion body. In another form the cushion may be formed with at least a portion having a plurality of adjacent voids having honeycomb-like structure.

Abstract: A respiratory mask can have a frame supporting a sealing arrangement. Various features of the frame and sealing arrangement can improve comfort and reduce the occurrence of pressure sores. The frame can include cheek supports that have a large surface area configured to spread loads over a greater area of the patient's face and therefore reduce the forces applied to the face and the occurrence of point loads. The seal can have a main body that includes a spring with a silicone skin, wherein the spring applies a substantially constant force to the face and/or nares of the patient.

Abstract: The invention relates to a multifunctional applicator 6 for mobile use having an applicator plug 7, a supply tube 8, a Y-piece 9, fork tubes 10 and a nose piece 11 with prongs 12, wherein the applicator plug 7 comprises a pressure chamber 21 that has a humidifier interface 17 for connection with a high flow therapy device 1, an oxygen supply port 13 having an opening diameter of at least 1 mm, and a therapy air supply port 14 for the supply tube 8, the humidifier interface 17 and the oxygen supply port 13 within the pressure chamber 21 are both in fluid communication with an upper and a lower valve seat 23, 25 that are provided with a seal 22 and a valve body 24 being movable between said valve seats 23, 25 and said valve body 24 being subjected to a force by a helical compression spring 26 from the direction of the oxygen supply port 13 and on the other hand being pushed against the upper valve seat 25 by an actuating element 28 of the high flow therapy device 1 when the applicator plug 7 is locked in place

Abstract: A mount configured for use within a respiratory system that provides a structure that facilitates coupling of a nebuliser downstream of a humidifier chamber and upstream of a conduit that delivers conditioned breathing gases to a patient or user. The mount can couple together a chamber, a nebulizer and a conduit.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: A flow control apparatus includes an adjustable pressure regulator fluidly coupled to an inlet region and an outlet region and configured to reduce a pressure from a first value in the inlet region to a second value in the outlet region, where the second value is lower than the first value; and a fixed area orifice disposed between the outlet region and an outlet opening of the apparatus, wherein a flow rate of a gas is controlled by the fixed area orifice and is discharged from the apparatus to a gas supply line. The second value is based on a setting of the adjustable pressure regulator.