Abstract: A water treatment system is provided with an untreated water reservoir having a cavity through which a filter assembly may traverse such that untreated water in the cavity passes through the filter assembly into a treated water reservoir. Removal of the filter assembly may be facilitated by a seal disengagement element operable to unseat a seal formed during efforts to direct untreated water through the filter assembly.

Abstract: A new wet oxidation process of wastes, specifically of mixtures of at least two, liquid (wastewaters) and dense (sludges), pumpable wastes is described. An apparatus useful for a wet oxidation process of this type is also described.

Abstract: A hydrothermal treatment device (3) is a hydrothermal treatment device (3) performing hydrothermal treatment by heating high-water-content biomass, the hydrothermal treatment device (3) including a treatment container (21) that stores sludge, a sludge supply unit (22) that supplies the sludge to inside of the treatment container (21) such that a space (S) is formed in a vertical upper part of the treatment container (21), a stirrer (23) that is provided within the treatment container (21) and stirs stored matter such that counter flows in an up/down direction occur, and a heat transfer tube (24) that is disposed in a horizontal direction within the treatment container (21) and heats the sludge with heat of vapor flowing within the heat transfer tube (24).

Abstract: One aspect relates to a process for the preparation of a quartz glass body. The process includes providing a silicon dioxide granulate from a pyrogenically produced silicon dioxide powder, making a glass melt out of silicon dioxide granulate, and making a quartz glass body out of at least part of the glass melt. The size of the quartz glass body is reduced to obtain a quartz glass grain. The quartz glass body is processed to make a preform and an opaque quartz glass body is made from the preform. One aspect further relates to an opaque quartz glass body which is obtainable by this process. One aspect further relates to a reactor and an arrangement, which are each obtainable by further processing of the opaque quartz glass body.

Abstract: Embodiments of the disclosure relate to a method of controlling the flow of fluid, such as air, between a stack of glass sheets during a co-sagging process. In embodiments, this involves a particular method and certain mechanical means of applying force at or near the edges and/or corners of a stack of glass sheets during a co-sagging process. In other embodiments, this involves creating low pressure regions at or near the edges and/or corners during the co-sagging process. In particular, controlling the flow of fluid between glass sheets is particularly suitable for preventing shape mismatch between two glass sheets having different thicknesses and/or compositions.

Abstract: A manufacturing method of a glass panel for a glass panel unit includes a melting step, a spreading step, an annealing step, a cutting step, and a spacer disposition step. The spacer disposition step is a step of disposing spacers onto a glass sheet and is performed by a spacer disposition device prior to the cutting step.

Abstract: A method and device for the continuous heat treatment of pharmaceutical glass containers are provided. The method includes continuously conveying glass containers from an entry region to an exit region via a conveying installation having a separating plate made from an electrically conductive material, the separating plate being positioned above and/or below the conveying installation; heating the glass containers to a maximum temperature in a heating zone after passing the entry region; cooling the glass containers in a first cooling zone after passing the heating zone and before passing the exit region at a first cooling rate, wherein the separating plate separates the glass containers from heating installations in the heating zone and/or temperature changing installations in the first cooling zone; and controlling the heating installations and/or the temperature changing installations to inductively heat the separating plate in the heating zone and/or the first cooling zone.

Abstract: The present disclosure provides a method for fabrication of an optical fibre soot preform. The method includes production of silicon dioxide particles along with waste particulates. The silicon dioxide particles are produced using a precursor material in a combustion chamber. In addition, the method includes cooling of the silicon dioxide particles. Further, the method includes agglomeration of the silicon dioxide particles. Furthermore, the method includes separation of the waste particulates from the silicon dioxide particles. Moreover, the method includes dehydration of the silicon dioxide particles. Also, the method includes compaction of the silicon dioxide particles. The compaction of the silicon dioxide particles facilitates fabrication of the optical fibre soot preform.

Abstract: A fiber draw furnace includes a heated section configured to contain and heat a glass source from which an optical fiber is drawn. A lower extended muffle having a first end and a second end. A gas screen is coupled to the second end of the lower extended muffle configured to allow a gas to flow into the lower extended muffle. A reclaim cylinder is coupled to the lower extended muffle including an outer housing defining a reclaim chamber. A plurality of reclaim ports are tangentially coupled to the outer housing and an inner housing is positioned within the outer housing.

Abstract: The present invention pertains to a glass characterized by: containing 72-82% of Li+, 0-21% of Si4+, and 0-28% of B3+ in terms of cation %; and containing at least 70% and less than 100% of O2? and more than 0% and at most 30% of Cl?, containing at least 94% and less than 100% of O2? and more than 0% and at most 6% of S2?, or containing at least 64% and less than 100% of O2?, more than 0% and at most 30% of Cl?, and more than 0% and at most 6% of S2?, in terms of anion %.

Abstract: Provided is optical glass containing, in terms of mol % of cations: 10 to 60% of a La3+ component; more than 0% and up to 75% of a Ga3+ component; and 5 to 75% of a Nb5+ component, in which a total amount of the La3+ component, Ga3+ component, and Nb5+ component is 60 to 100%.

Abstract: To provide an optical glass having the optical characteristics of a high refractive index and low dispersion, and moreover, which makes it possible to further reduce devitrification and which can be stably obtained, and a preform and an optical element using the same. The optical glass comprises, expressed in cation % (mol %), 17.0% to 42.0% of P5+, 7.0% to 30.0% of Al3+, more than 0% to 22.0% of Mg2+, more than 0% to 25.0% Ca2+, more than 0% to 30.0% of Sr2+, more than 0% to 35.0% Ba2+, and expressed in anion % (mol %), a content ratio of F? of 37.0 to 64.0%, a content ratio of O2? of 36.0 to 63.0%, a refractive index (nd) of 1.48 to 1.58, and having an Abbe number (vd) of 70 to 88, and a liquidus temperature of 800° C. or less.

Abstract: Embodiments of glass ceramic articles and precursor glasses are disclosed. In one or more embodiments, the glass-ceramic articles are transparent and include a nepheline phase and a phosphate phase. The glass-ceramic articles are colorless and exhibit a transmittance of about 70% or greater across the visible spectrum. The glass-ceramic articles may optionally include a lithium aluminosilicate phase. The crystals of the glass-ceramic articles may have a major cross-section of about 100 nm or less.

Abstract: A glass-ceramic that includes: SiO2 from about 35 mol % to about 80 mol %; B2O3 from about 10 mol % to about 50 mol %; P2O5 from about 10 mol % to about 50 mol %; and an optional addition of one or more of CaO, MgO and Bi2O3 from 0 mol % to about 5 mol %, wherein the glass-ceramic further comprises a boron-phosphate crystalline phase.

Abstract: A processing system for forming an optical coating on a substrate is provided, wherein the optical coating including an anti-reflective coating and an oleophobic coating, the system comprising: a linear transport processing section configured for processing and transporting substrate carriers individually and one at a time in a linear direction; at least one evaporation processing system positioned in the linear transport processing system, the evaporation processing system configured to form the oleophobic coating; a batch processing section configured to transport substrate carriers in unison about an axis; at least one ion beam assisted deposition processing chamber positioned in the batch processing section, the ion beam assisted deposition processing chamber configured to deposit layer of the anti-reflective coating; a plurality of substrate carriers for mounting substrates; and, means for transferring the substrate carriers between the linear transport processing section and the batch processing section

Abstract: Certain example embodiments relate to ultra-fast laser treatment of silver-inclusive (low-emissivity) low-E coatings, coated articles including such coatings, and/or associated methods. The low-E coating is formed on a substrate (e.g., borosilicate or soda lime silica glass), with the low-E coating including at least one sputter-deposited silver-based layer, and with each said silver-based layer being sandwiched between one or more dielectric layers. The low-E coating is exposed to laser pulses having a duration of no more than 10?12 seconds, a wavelength of 355-500 nm, and an energy density of more than 30 kW/cm2. The exposing is performed so as to avoid increasing temperature of the low-E coating to more than 300 degrees C. while also reducing (a) grain boundaries with respect to, and vacancies in, each said silver-based layer, (b) each said silver-based layer's refractive index, and (c) emissivity of the low-E coating compared to its as-deposited form.

Abstract: A tempered glass has a sheet thickness of 0.6 mm or less and having a compression stress layer resulting from chemical tempering at a surface thereof, which satisfies requirements of CS×(DOL?20)/DOL>360 and DOL/t?0.20 when the compression stress value of the compression stress layer is represented by CS (Mpa), the depth of the compression stress layer is represented by DOL (?m), and the sheet thickness is represented by t (?m).

Abstract: The purpose of the present invention is to provide a chemically strengthened glass in which reduction in glass surface strength is effectively suppressed even without performing a polishing treatment after a prolonged chemical strengthening treatment has been conducted at a high temperature. The present invention relates to a chemically strengthened glass having a specific glass composition, wherein: the surface roughness (Ra) is a specific value or greater; the compressive stress layer depth of a surface layer is a specific value or greater; by setting the hydrogen concentration in the glass surface layer to be within a specific range, the surface strength of the glass is dramatically improved even without performing an etching treatment using hydrofluoric acid or polishing the glass surface after a prolonged chemical strengthening treatment has been conducted at a high temperature.

Abstract: Glass articles and methods for modifying a composition of a surface portion of the glass article are disclosed. The method includes heating the surface portion of the glass article with a laser beam to a temperature within a range of about 1100?C to about 2200?C such that the heating evaporates one or more metalloids and/or one or more alkali metals present at the surface portion, and modifies the composition of the surface portion such that the surface portion has a lower alkali metals concentration and/or a lower metalloids concentration as compared to a portion of the glass article that is not heated by the laser beam.

Abstract: The invention comprises a cementitious material comprising a natural pozzolan selected from hyaloclastite, sideromelane or tachylite, wherein the natural pozzolan has a volume-based mean particle size of less than or equal to 40 ?m. The cementitious material also comprising an aqueous alkaline activating solution suitable for forming a geopolymer. A method making a cementitious material is also disclosed.

Abstract: A composite material and process for forming composite material. The composite material comprises a quantity of plastinated plant distributed within a matrix material. The process comprises separating a plant material into plant fibers plastinating the plant fibers and combining the plastinated plant fibers with a matrix material. The plant fibers may be selected form the group consisting of bamboo, hemp and flax. The plant fibers may be formed by crushing a portion of a plant. The matrix material may comprise Polyethylene Terephthalate (PET). The PET may be shredded and heated. The heated composite material may be formed into rebar and be arranged in a pattern within a concrete slurry.

Abstract: Methods and systems for fabricating synthetic source rocks with organic materials, for example, using high energy resonant acoustic mixing technology, are provided. An example method includes preparing one or more organic components including kerogen, mixing, by utilizing resonant acoustic waves, the one or more organic components with one or more inorganic components to obtain a mixture, and processing the mixture to fabricate a synthetic source rock. Another example method includes mixing one or more organic components and one or more inorganic components with a kerogen precursor as an organic binder to obtain a mixture including artificial kerogen and processing the mixture to fabricate a synthetic source rock. One or more mechanical or chemo-mechanical properties of the synthetic source rock can be characterized as one or more functions of the one or more organic components and the one or more inorganic components.

Abstract: Systems for and methods of manufacturing a ceramic matrix composite include introducing a gaseous precursor into an inlet portion of a reaction furnace having a chamber comprising the inlet portion and an outlet portion that is downstream of the inlet portion, and delivering a mitigation agent, such as water vapor or ammonia, into an exhaust conduit in fluid communication with and downstream of the outlet portion of the reaction chamber so as to control chemical reactions occurring with the exhaust chamber. Introducing the gaseous precursor densities a porous preform, and introducing the mitigation agent shifts the reaction equilibrium to disfavor the formation of harmful and/or pyrophoric byproduct deposits within the exhaust conduit.

Abstract: An apparatus for making a composite article includes a monofilament feed track adapted to carry a spaced array of ceramic monofilament strands, a fiber yarn feed track adapted to carry a spaced array of fiber yarn tows impregnated with a plurality of glass particulates, a mandrel, and a heater assembly. The mandrel is adapted to wind together individual glass-impregnated fiber yarn strands and individual ceramic monofilament strands to form a dual-fiber weave. The heater assembly is adapted to heat at least the glass particulates such that pressure from the wound array of ceramic monofilaments is sufficient to consolidate the glass particulates and the dual-fiber weave into a dual-fiber ceramic matrix composite (CMC).

Abstract: A method for forming a protective coating on a surface of a ceramic substrate includes combining a rare-earth oxide, alumina, and silica to form a powder, etching the surface of the ceramic substrate, applying the powder on the etched surface in an amount of from about 0.001 to about 0.1 g/cm2 to reduce capture of bubbles from off-gassing of the ceramic substrate, heating the powder for a time of from about 5 to about 60 minutes to a temperature at or above the melting point such that the powder melts and forms a molten coating on the surface that has a minimized number of bubbles, and cooling the molten coating to ambient temperature to form the protective coating disposed on and in direct contact with the surface of the ceramic substrate such that the protective coating has a thickness of less than about 1 mil.

Abstract: The invention relates to a process for metallizing ferrite ceramics, which comprises the following steps: arrangement of a contact element composed of copper or a copper alloy on a surface of the ferrite ceramic, melting of the contact element at least in the region in which the contact element contacts the surface of the ferrite ceramic, and cooling of the contact element and the ferrite ceramic to below the melting point of copper or the copper alloy.

Abstract: Controlling insect damage in a plant. In one embodiment, the methods include applying insecticide and at least one fertilizer in-furrow at planting. In particular examples, methods of controlling cutworms in corn include applying tefluthrin and at least one pop-up fertilizer in-furrow at planting.

Abstract: The present disclosure generally provides a fertigation process comprising providing a nitrification inhibitor composition; providing a urea ammonium nitrate fertilizer composition; combining the nitrification inhibitor composition with the fertilizer composition; and applying the combined composition during a growing cycle of a crop using an overhead irrigation system. The present disclosure also relates to this fertigation process wherein the nitrification inhibitor comprises dicyandiamide and dimethyl sulfoxide and the crop is corn.

Abstract: Disclosed are processes for conversion of a feedstock comprising C8+ aromatic hydrocarbons to lighter aromatic products in which the feedstock and optionally hydrogen are contacted in the presence of the catalyst composition under conversion conditions effective to dealkylate and transalkylate said C8+ aromatic hydrocarbons to produce said lighter aromatic products comprising benzene, toluene and xylene. The catalyst composition comprises a zeolite, a first metal, and a second metal, and is treated with a source of sulfur and/or a source of steam.

Abstract: Processes are described for separating 3,4?- and 4,4?-dimethylbiphenyl from a mixture comprising at least 3,3?-, 3,4?- and 4,4?-dimethylbiphenyl. In the processes, the mixture is cooled to produce a crystallization product comprising at least of the 4,4?-dimethylbiphenyl from the feed mixture and a first mother liquor product. The first mother liquor product is distilled to produce a bottoms stream enriched in 4,4?-dimethylbiphenyl as compared with the first mother liquor product and an overhead stream deficient in 4,4?-dimethylbiphenyl as compared with the first mother liquor product. The overhead stream is then cooled to produce a second crystallization product comprising at least part of the 3,4?-dimethylbiphenyl from the overhead stream and a second mother liquor product.

Abstract: A three step synthesis of the 8,12-dihydro-4H-dibenzo[cd,mn]pyren-3a2-ylium cation (triangulenium cation) is effected by cascade cyclization of a tetra-benzyl alcohol precursor in triflic acid solution. This cation is easily observed by NMR and optical spectroscopy. Quenching of the cation into basic solutions or by hydride transfer from triethylsilane provides access to stable dihydro and tetrahydro[3]triangulenes. This route makes several [3]triangulene precursors more readily available for development of new applications in the field of molecular electronics.

Abstract: The present disclosure provides a method for producing fluoroolefin represented by formula (1): CX1X2?CX3X4, wherein X1, X2, X3, and X4 are the same or different, and represent a hydrogen atom or a fluorine atom, with high selectivity. Specifically, the present disclosure is a method for producing a fluoroolefin represented by formula (1) described above, the method comprising a dehydrofluorination step of bringing a fluorocarbon represented by formula (2): CX1X2FCX3X4H, wherein X1, X2, X3, and X4 are as defined above, into contact with a metal catalyst to perform dehydrofluorination, the dehydrofluorination step being performed in the gas phase in the presence of water, the concentration of the water being less than 500 ppm relative to the fluorocarbon represented by formula (2).

Abstract: The present application provides systems and methods for producing isononanol and gasoline and diesel blending components. In at least one embodiment of the present systems and methods, a hydrocarbon feed is cracked in a steam cracker to form a first ethylene stream, a first propylene stream, and a C4 stream comprising isobutene and butadiene. The C4 stream is reacted with a methanol stream in a methyl tertiary butyl ether (MTBE) unit to form MTBE and a butadiene-rich C4 stream. The butadiene-rich C4 stream is selectively hydrogenated in a butadiene unit to form a butene-rich C4 stream. The butene-rich C4 stream undergoes a series of reactions in an isononanol unit to produce isononanol and an olefin-rich stream. The olefin-rich stream is then separate, in a separation unit, a C8, C12, and C16 fuel oil streams.

Abstract: A process for dehydrating methanol to dimethyl ether using a Brønsted acid catalyst which is a 1-dimensional or a 3-dimensional aluminosilicate zeolite or a heteropolyacid, and a promoter of Formula I CnH(2n+1)CO2CH3 wherein n=1 to 11 or Formula II CmH2m(CO2CH3)2 wherein m=2 to 7 and the molar ratio of promoter to methanol is maintained at less than 1.

Abstract: The present application pertains to methods for making metal oxides and/or citric acid. In one embodiment, the application pertains to a process for producing calcium oxide, magnesium oxide, or both from a material comprising calcium and magnesium. The process may include reacting a material comprising calcium carbonate and magnesium carbonate. Separating, concentrating, and calcining may lead to the production of oxides such as calcium oxide or magnesium oxide. In other embodiments the application pertains to methods for producing an alkaline-earth oxide and a carboxylic acid from an alkaline earth cation—carboxylic acid anion salt. Such processes may include, for example, reacting an alkaline-earth cation—carboxylic acid anion salt with aqueous sulfur dioxide to produce aqueous alkaline-earth—bisulfite and aqueous carboxylic acid solution. Other useful steps may include desorbing, separating, and/or calcining.

Abstract: Provided is a process for preparing acrylic acid comprising (1) preparing acrolein by catalytic gas phase oxidation comprising (a) providing a reaction gas comprising (i) 5 to 10 mol % propylene, (ii) 0.02 to 0.75 mol % propane, and (iii) 0.25 to 1.9 mol % of a fuel mixture comprising at least one of methane and ethane, wherein the molar ratio of the total amount of propane, methane, and ethane to the total amount of propylene is from 0.01:1 to 0.25:1, (b) contacting the reaction gas with a first mixed metal oxide catalyst to form a mixture comprising acrolein, wherein the first mixed metal oxide catalyst comprises one or more of molybdenum, bismuth, cobalt, and iron, and (2) contacting the acrolein mixture with a second mixed metal oxide catalyst to form a mixture comprising acrylic acid, wherein the second mixed metal oxide catalyst comprises one or more of molybdenum, vanadium, tungsten, copper, and antimony.

Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.

Abstract: A method for recovering a composition enriched in 3-hydroxypropionic acid from a fermentation broth comprising 3-hydroxypropionic acid and/or salts thereof comprises the steps of: (a) providing the fermentation broth having a pH of from about 2 to about 8 comprising 3-hydroxypropionic acid and/or salts thereof (b) acidifying the fermentation broth; (c) reducing the total sulfate ion and phosphate ion (d) distilling the resulting reduced ion aqueous solution and (e) recovering the product.

Abstract: A method for recovering a composition enriched in 3-hydroxypropionic acid by providing the fermentation broth, acidifying the fermentation broth; reducing the total sulfate ion and phosphate ion concentration of the resulting aqueous solution to produce a reduced ion aqueous solution; distilling the resulting reduced ion aqueous solution and recovering the resulting aqueous distillation product comprising 3-hydroxypropionic acid.

Abstract: This invention relates to a method for the conversion of lignocellulosic biomass into ethyl esters of carboxylic acids. Said method consists of treating the biomass material with an oxidizing agent that is incorporated in an solution comprising one or more acids, one or more alcohols and water, and subsequently performing a catalytic reaction at a higher temperature using the same acidic solution into which a larger volume of alcohol is added, in such a way that the catalytic conversion occurs in a medium with a much higher concentration of alcohol, i.e. with a much higher alcohol-to-water wt ratio. Such a method results in relatively high yields of ethyl esters, such as ethyl esters of formic, acetic, and levulinic acids, while producing a low yield of dialkyl ethers, which are unwanted by-products. The concentration of the oxidizing agent in the pre-treatment step is preferably higher than 6.0 wt %.

Abstract: The invention pertains to a process for converting a feedstock comprising cyclic alkyleneureas into their corresponding alkyleneamines, comprising —a CO2 removal step in which cyclic alkyleneureas are converted into their corresponding alkyleneamines by reacting cyclic alkyleneureas in the liquid phase with water with removal of CO2, —an amine removal step wherein cyclic alkyleneureas are converted in a reactive separation process into their corresponding alkyleneamines by reaction with an amine compound selected from the group of primary amines or secondary amines which have a higher boiling point than the alkyleneamines formed during the process. It has been found that the combination of a CO2 removal step and an amine removal step makes it possible to convert alkyleneureas into the corresponding amines in an efficient manner in a high reaction rate.

Abstract: Disclosed herein are the multiple charged cationic or anionic compounds, methods of making thereof, and articles or compositions comprising thereof. The disclosed multiple charged cationic or anionic compounds are derived from polyamines through two reactions: an aza-Michael addition with an activated olefin having an ionic group and a ring-opening reaction with an epoxide.

Abstract: The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

Abstract: A cooling agent composition includes a methyl menthol derivative represented by the following general formula (1). In the formula (1), a symbol * indicates an asymmetric carbon atom, X represents a hydrogen atom or a substituent, and Y represents an aryl group having 6 to 20 carbon atoms which may have a substituent.

Abstract: A process for the production of ammonia and urea in an ammonia-urea integrated plant comprising an ammonia section and a tied-in urea section, wherein a hydrocarbon is reformed to produce ammonia make-up synthesis gas; said make-up gas is purified by shift conversion and removal of carbon dioxide; carbon dioxide is removed from the make-up gas by a first and a second CO2 removal sections; the first section removes CO2 by absorption with a suitable medium, and the second section removes CO2 by washing with a carbamate solution taken from the urea section; the make-up gas is reacted to produce ammonia; the CO2 removed from the make-up gas and at least part of the ammonia are used to produce urea.

Abstract: Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as the compounds of the invention belong to the family of NOD-like receptor family (NLR) protein NLRP3 modulators. The present invention thus relates to novel NLRP3 modulators as well as to the use of the novel inhibitor compounds in the treatment of diseases or conditions as well as treatment of disease states mediated by NLRP3 as well as treatment of diseases or conditions in which interleukin 1? activity and interleukin-18 (IL-18) is implicated.

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract: The invention provides a combination comprising: (i) a compound of formula (Io): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims; and (ii) a compound which is SGI-110 or a tautomer or a solvate or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions containing the combinations and medical uses of the combinations.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.