Abstract: Embodiments of a hybrid imaging sensor that optimizes a pixel array area on a substrate using a stacking scheme for placement of related circuitry with minimal vertical interconnects between stacked substrates and associated features are disclosed. Embodiments of maximized pixel array size/die size (area optimization) are disclosed, and an optimized imaging sensor providing improved image quality, improved functionality, and improved form factors for specific applications common to the industry of digital imaging are also disclosed. Embodiments of the above may include systems, methods and processes for staggering ADC or column circuit bumps in a column or sub-column hybrid image sensor using vertical interconnects are also disclosed.

Abstract: A medical observation system according to an embodiment of the present technology includes a light source, an optical member, a first light guide body, and an imaging element. The light source has a plurality of light-emitting elements, each of which emits light. The optical member is arranged to reflect the light emitted from the plurality of light-emitting elements and make the reflected light incident on a first region. The first light guide body is arranged in the first region, has an incident end and an emission end on a side opposite to the incident end, and guides the light incident from the incident end to the emission end. The imaging element irradiates an operating field with the guided light and captures an image of light reflected by a subject.

Abstract: The present disclosure provides improved methods and apparatus for evaluation of an individual's cognitive performance in a fast-paced, visually dynamic environment. The apparatus may comprise a display configured to present a plurality of stimuli to the subject, and a processor coupled to the display, the processor comprising instructions to determine a subject's visual perceptual skills, memory and learning skills, and response command and control skills. The methods and apparatus described herein can evaluate key cognitive processes that underlie split-second decision-making in visually dynamic environments. The results can provide comparison of cognitive skills across individuals performing in a specific environment, as well as evaluations of more targeted sets of cognitive processes for specific positions in an environment that might require unique sets of skills.

Abstract: A visual stimulus for a set of contrast cards is provided which comprises a hollow outer circle, opposing and identical first and second arc segment within the outer circle which are symmetrical about the vertical diameter of the outer circle, a first filled-in circle and a second filled-in circle being identical in diameter to the first filled-in circle, each residing on opposite ends of the horizontal diameter of the outer circle and each being equidistant from the center of the outer circle, a filled-in center element having a rotational center on the center of the outer circle, the center element being symmetrical about both the horizontal and vertical diameter of the outer circle.

Abstract: Disclosed is a method for determining at least one geometrico-morphological parameter of a subject for determining a vision correction equipment, wherein the following steps are performed: a) determining the height of one of the eyes of the subject (P) relative to a reference horizontal surface; b) placing a visual target in front of the head (HP) of the subject (P) at a predetermined position, this predetermined position being determined taking into account the height of one of the eyes of the subject relative to the reference horizontal surface, determined in step a); c) while the subject gazes at the visual target placed at the predetermined position in step b), capturing an image of the head (HP) of the subject (P) with an image capture apparatus (50); and d) deducing from the image captured in step c) the at least one geometrico-morphological parameter.

Abstract: The object of the present invention is to develop an ophthalmologic microscope of a new method that increases the degree of freedom in the optical design in the Galilean ophthalmologic microscope provided with an OCT optical system. The present invention provides an ophthalmologic microscope, wherein an observation optical system, an objective lens, and an OCT optical system are placed in such a way that the optical axis of the OCT optical system does not penetrate through objective lens, and the optical axis of the observation optical system and the optical axis of the OCT optical system are non-coaxial, and wherein the ophthalmologic microscope further comprises a SLO optical system that scans a light ray which is a visible ray, a near infrared ray, or an infrared ray and guides the light to the subject's eye so as to become substantially coaxial with the optical axis of the OCT optical system.

Abstract: An ultrasonic tonometer, which measures an intraocular pressure of a subject eye using an ultrasonic wave, has an ultrasonic actuator including an ultrasonic element that generates an ultrasonic wave and a sonotrode that propagates the ultrasonic wave generated from the ultrasonic element, and irradiating the subject eye with the ultrasonic wave. The sonotrode includes an uneven portion in which a thickness of the sonotrode varies in a sound axis direction of the ultrasonic wave.

Abstract: Systems and methods may include a first monitoring device positioned at a first location to monitor a monitored environment; and a second monitoring device positioned at a second location to monitor the monitored environment, wherein the first and second monitoring devices calibrate each other based on respective fiducial markers; wherein the first and second monitoring devices each comprise a processor and a memory coupled to the processor, the memory storing a plurality of instructions, which when executed by the processor, cause the processor to perform the operations of: detecting presence of the individual in the monitored environment; determining whether the condition of interest of the individual exceeds a determined threshold; based on the condition of interest of the individual exceeding the determined threshold, transmitting the condition of interest to a remote server to determine at least one of a social distancing breach and an identification of another person whom the individual contacted.

Abstract: A method and system for detecting a possible stroke in a person through the analysis of voice data and image data regarding the gate of the user, facial features and routines, and corroborating any anomalies in one set of data against anomalies in another set of data for a related time frame.

Abstract: A remote interface system according to some embodiments includes one or more patient monitoring devices having one or more sensors for patient monitoring, one or more first processors to receive information from the sensors and generate patient data based thereon, a web server, a first communication system, and a first screen to display a representation of at least a first portion of the patient data, and a remote interface device including a second communication system, a second screen, one or more second processors, an application executed by the one or more second processors and configured to detect a presence of the first communication system, establish a communication link between the first and second communication systems, establish a reliable connection channel (e.g. secure websocket connection) with the web server, receive the patient data via the connection, and display at least a second portion of the patient data on the second screen.

Abstract: An MRI-CT system and methods for sequentially (or simultaneously) imaging a subject involving a CT component for initially performing CT imaging, an MR component for subsequently performing MR imaging, the MR component and the CT component disposable in relation to one another in at least one of linearly aligned and colinearly aligned, and a movable barrier disposable between the CT component and the MR component, the movable barrier comprising a magnetic shield, and the movable barrier disposable in one of an open position and a closed position during MRI scanning by the MR component and in a closed position during CT scanning by the CT component.

Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest.

Abstract: A device may obtain imaging data. The imaging data that is obtained depicts one or more body parts of a patient. A voltage sensitive dye may be applied to stain nerve tissue associated with the one or more body parts of the patient. The voltage sensitive dye may be activated by neuromodulation applied to stimulate the nerve tissue. The imaging data may capture a fluorescence of the nerve tissue based on the voltage sensitive dye being activated by neuromodulation. The device may provide the imaging data for display.

Abstract: A method of measuring light intensity for imaging using a light detector array comprising a plurality of light detectors arranged to generate an output corresponding to an intensity of incident light. In a first measurement mode the light detector array generates a first plurality of output signals, each generated by one group of proximate light detectors, each group comprising a light detector pair, the first plurality of output signals each corresponding to a difference between the light intensity detected by the light detectors of the group, and generating a light intensity measurement for each group from each received output signal of the first plurality of output signals. In a second measurement mode the light detector array generates a second plurality of output signals, and a light intensity measurement is generated for each light detector from the second plurality of output signals.

Abstract: A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

Abstract: A system (100) for detecting tissue inflammation, and gingivitis specifically, including a light emitter (102) configured to emit light at a tissue region (104) within a user's mouth; a light detector (106) configured to detect optical signals diffusely reflected through the tissue region over a period of time; a controller (130) configured to: determine a slope signal (Q) based on at least two signals (R(?1), R(?2)) from the optical signals, the at least two signals including at least one signal from a hemoglobin-dominated wavelength range; determine one or more characteristics of the slope signal; and select a best measurement signal based on the one or more characteristics of the slope signal. The system further includes a user interface (116) configured to provide information regarding a position of a probe for accurate detection of tissue inflammation based on the one or more characteristics of the slope signal.

Abstract: An optoacoustic imaging system includes an ultrasound transducer array, first and second light sources and a switching power supply that generates power for the light sources. The switching power supply includes an input for impeding its switching operation. A data acquisition unit samples the ultrasound transducer array for a first predetermined period of time after a pulse of light from the first light source and for a second predetermined period of time after a pulse of light from the second light source and stores the sampled data. A master processor utilizes the input to impede operation of the switching operation of the switching power supply during the first predetermined period of time after a pulse of light from the first light source, and during the second predetermined period of time after a pulse of light from the second light source.

Abstract: Population malady identification with a wearable glucose monitoring device is described. A malady identification system obtains temperature measurements that are produced by wearable glucose monitoring devices worn by users of a user population. The malady identification system further obtains location data describing locations of the users and associates each of the temperature measurements with a respective location. The malady identification system utilizes identification logic (e.g., one or more machine learning models) to identify presence of a malady in the users at one or more of the locations based on the temperature measurements and the location data. The malady identification system generates a communication for notifying at least one of the users about the presence of the malady.

Abstract: Techniques and apparatuses are described that implement a smart device-based radar system capable of detecting human vital signs using a compact circularly-polarized antenna. A radar system includes at least one compact circularly-polarized antenna with a patch antenna and a quadrature hybrid coupler. The quadrature hybrid coupler is on a separate plane that is above or below the patch antenna. By vertically stacking the patch antenna with the quadrature hybrid coupler, lateral dimensions of the radar system can be reduced relative to other antenna configurations or designs. The quadrature hybrid coupler can also have a ring-shape design to improve isolation and polarization purity of the compact circularly-polarized antenna relative to a rectangular design. The compact circularly-polarized antenna enables a radar system operating at frequencies between approximately 1 gigahertz (GHz) and 24 GHz to be implemented within a variety of small smart devices.

Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.

Abstract: Disclosed is a bio-signal monitoring device including an electrocardiogram detector, one or more sensor units, a controller configured to process the electrocardiogram signal or a sensing signal received from the sensor units, a connector configured to be connected to the sensor units and to transmit, to the controller, a sensing signal from the sensor units, and a communicator configured to communicate with an external electronic device. The sensing units include a breathing rate sensor, an acceleration sensor, a temperature sensor, or a combination thereof.

Abstract: A bio-information estimating apparatus includes a sensor part configured to measure a pulse wave signal from an object, a contact force that is applied by the object to the sensor part, and a contact area of the object that is applied to the sensor part, and a processor configured to obtain a first feature value, based on a first change in the contact area with respect to a second change in the contact force, obtain a second feature value, based on the pulse wave signal, and estimate bio-information, based on the first feature value and the second feature value.

Abstract: The invention relates to measuring blood pressure and the calibration of said measurement. Here, the intention is to specify solutions which facilitate a more accurate and/or less burdensome measurement. To this end, it is proposed to take pressure measurements in certain respiratory states and/or to undertake the calibration by means of pressure variations without physical activity, i.e., on account of respiration or changes in position, and/or separately for systolic pressure and diastolic pressure.

Abstract: In an example, this document discloses an apparatus for insertion into a body lumen, the apparatus comprising an optical fiber pressure sensor. The optical fiber pressure sensor comprises an optical fiber configured to transmit an optical sensing signal, a temperature compensated Fiber Bragg Grating (FBG) interferometer in optical communication with the optical fiber, the FBG interferometer configured to receive a pressure and modulate, in response to the received pressure, the optical sensing signal, and a sensor membrane in physical communication with the FBG interferometer, the membrane configured to transmit the received pressure to the FBG interferometer.

Abstract: A connection system for a sphygmomanometer including: an inflatable cuff adapted to be placed on a limb of a patient, the cuff includes an inflatable pouch, a flexible tube including a first end and a second end, the first end in fluid communication with the inflatable pouch of the cuff, an inflation bulb formed by an inflator bulb connected to a pressure gauge for measuring blood pressure, a connection member mounted in the inflation bulb to connect the second end of the tube to the inflation bulb, the tube adapted to provide a direct link between the inflation bulb and the cuff, the second end of the tube includes a male end-piece and the connection member includes a female connector for removably receiving the male end-piece, the connection member includes a portion that cooperates with a complementary portion provided on the male end-piece of the tube.

Abstract: In a biological information measurement device, an internal pressure controller increases or decreases an internal pressure of a compression band wrapped around a part of a living body. A time-series data acquisition unit acquires time-series data of the volume and the internal pressure of the compression band while the internal pressure of the compression band increases or decreases. A relationship deriving unit derives a relationship between the volume and the internal pressure of the compression band based on the time-series data. A determination unit differentiates the relationship between the volume and the internal pressure with respect to the internal pressure to derive a first differential value, differentiates the first differential value with respect to time or the internal pressure to derive a second differential value, and determines the internal pressure at the peak of the second differential value as the blood pressure of the living body.

Abstract: The present invention provides a wrist-worn blood pressure monitor that is worn around a wrist. The wrist-worn blood pressure monitor according to the present invention includes a wrist cuff including a wrist strap so as to be worn around a wrist, a sensor provided at the wrist cuff in order to measure blood pressure, and a tightener provided at the wrist cuff in order to selectively tighten the wrist cuff so that the wrist cuff compresses the wrist. According to the present invention, a user is able to conveniently measure his/her blood pressure whenever there is a need to measure the blood pressure, and the accuracy of the measured blood pressure is increased since the wrist-worn blood pressure monitor is securely tightened around the wrist.

Abstract: Variations in pulse shape over time can be used to draw inferences about activity, health, and age of an individual. For example, PPG pulses may be mapped to a latent space where variations in shape can be measured directly in terms of distance between pulses. In one aspect, pulse-to-pulse comparisons for an individual can be used to estimate strain, recovery, sleep, and so forth. Longer term measurements (e.g., over weeks, month, or years) can be used to detect changes in health and fitness for the individual. In another aspect, pulse-to-pulse comparisons among different individuals can be used to estimate relative cardiovascular health, age, and the like.

Abstract: A detection device includes a first optical sensor, a second optical sensor disposed at a predetermined distance from the first optical sensor, a light source that emits light to be detected by the first optical sensor and the second optical sensor facing a living body tissue including a blood vessel, and a processor that calculates a pulse wave velocity of the blood vessel based on a time-series variation of an output of the first optical sensor, a time-series variation of an output of the second optical sensor, and the predetermined distance.

Abstract: A biosignal measurement apparatus comprises a data processing unit, and a first sensor, which is attachable to a surface of a body section at or adjacent to ribs and/or a neck and configured to convert movement pulses of the body section caused by muscular work of a heart at systolic and diastolic phases into pulses of an electric signal. The data processing unit receives the electric signal from the first sensor, and forms and outputs data about blood pressure on the basis of a characteristic feature of at least one of the movement pulses associated with the systolic phase and/or a characteristic feature of at least one of the movement pulses associated with the diastolic phase.

Abstract: This disclosure is directed to devices, systems, and techniques for dynamically adjusting a bio impedance measurement range. An example device includes a plurality of electrodes. The device also includes sensing circuitry configured to sense a bio impedance and processing circuitry. The processing circuitry is configured to apply an excitation signal to the sensing circuitry and, based on the application of the excitation signal, determine a sensed bio impedance value within a bio impedance measurement range. The processing circuitry is also configured to determine whether the sensed bio impedance value is within a predetermined portion of the bio impedance measurement range for a predetermined period of time and based on the sensed bio impedance value being within the predetermined portion of the bio impedance measurement range for the predetermined period of time, adjust the excitation signal.

Abstract: In variants, a method for signal enhancement includes: sampling a set of measurements of a signal source; and determining a SNR-enhanced signal based on the measurements, which, in variants, can include recursively cross-correlating elements for d iterations S200; and determining a SNR-enhanced signal from the cross-correlation outputs. The method functions to determine a SNR-enhanced signal representative of the signal source. The method can optionally include determining an analyte parameter based on the SNR-enhanced signal.

Abstract: The disclosure relates to a system for immobilizing and supporting a subject in a medical procedure. The system may include a treatment apparatus configured to generate a radiation beam, and a device for immobilizing a subject. The device may include an immobilizing component for immobilizing at least one portion of the subject, and a radio frequency (RF) coil configured to receive a magnetic resonance (MR) signal related to the at least one portion of the subject. The immobilizing component may be configured to switch between a first mode and a second mode. The first mode may correspond to a positive pressure or a constant pressure related to the device. The second mode may correspond to a space of vacuum or substantially of vacuum related to the device. The RF coil may be located in the immobilizing component according to a position where the radiation beam is incident on the device.

Abstract: The present disclosure describes a method and device to monitor the heart of a subject using radio signals. Availability of a portable heart monitor that can be used in a subject's home can increase patient compliance and improve diagnosis rates of cardiac conditions. A mobile heart monitor can be especially useful to those subjects who are elderly, incapacitated, or do not have easy access to a clinic, doctor's office, or hospital.

Abstract: [Problem] To accurately check a usage status of a medical product such as a damage status of the medical product or existence or nonexistence of the medical product. [Solution] A medical product (80) is configured to include a light-emissive septum (83) (constituent member) which includes a luminescent agent emitting near-infrared fluorescence according to irradiation of excitation light on a surface thereof. Even in a case where a portion of the septum is separated as a core (83a) (separate piece) due to damage, the luminescent agent is also included on a surface of the core.

Abstract: A breath sampler for collecting a breath sample from a patient is disclosed. The breath sampler has a non-rebreather part including a sample inlet, a one-way outlet valve downstream of the sample inlet, and an air inlet. The one-way outlet valve and the sample inlet define a first portion of an internal breath flow pathway therebetween. The air inlet is arranged to be closed by a one-way inlet valve arranged to allow air to enter the non-rebreather part. The breath sampler also has a sample delivery part in fluid communication with the non-rebreather part at an upstream end via the one-way outlet valve. The sample delivery part defines a second portion of the internal breath flow pathway, and has an air diverter, a sample outlet, a return inlet and a sample collection chamber connector.

Abstract: The present invention provides an improved breath analyzer and breath test method to determine the presence of a gastrointestinal disorder in a human subject's digestive tract.

Abstract: A contactless breathing detection method is for detecting a breathing rate of a subject. The contactless breathing detection method includes a photographing step, a capturing step, a calculating step, and a converting step. The photographing step is performed to provide a camera to photograph the subject to generate a facial image. The capturing step is performed to provide a processor module to capture the facial image to generate a plurality of feature points. The calculating step is performed to drive the processor module to calculate the feature points according to an optical flow algorithm to generate a plurality of breathing signals. The converting step is performed to drive the processor module to convert the breathing signals to generate a plurality of power spectrums, respectively. The processor module generates an index value by calculating the power spectrums, and the breathing rate is extrapolated from the index value.

Abstract: Disclosed herein is a sampling face mask for harvesting substances exhaled from the nose of its user, in which the risk of cross-contamination of the exhaled substances by its surrounding environment or by the process of handling the sampling mask with hand(s) or additional tools is reduced to a minimal.

Abstract: A stroke detection apparatus comprises a data processing device comprising a processor and at least one wearable sensor configured to generate movement data of at least a portion of the user's body. The data processing device is configured to process first movement data for a first movement and second movement data for a second movement received from the at least one wearable sensor. Wherein the data processing device is configured to determine asymmetry of user's movement based on the first and second movement data and generate a stroke detection signal in dependence on the determined asymmetry.

Abstract: Systems and methods of the present disclosure include a five-layer environment consisting tremor management hardware, interface, control system, machine learning environment and cloud capabilities. These elements come together to implement program instructions and perform steps to: receive sensory data elements(s) for tremor stat(s), physiological and/or environmental state(s) of the user, user activities and state(s) of the tremor management hardware and based on these state(s) generate at least one actionable tremor mitigation action associated with historical tremor mitigation improvements recorded in a memory, and display at a user computing device the at least one actionable tremor mitigation action to a user, a healthcare provider, or both.

Abstract: The invention provides a gait evaluating system and a gait evaluating method. The gait evaluation system includes a gait evaluating device configured to: obtain, from a pressure detection device, a plurality of pressure values of a user walking on the pressure detection device; obtain a plurality of step feature values of the user based on the pressure values; obtain a plurality of walking limb feature values when the user walks on the pressure detection device based on a sensing data provided by a limb sensing device; and evaluate a gait of the user based on the step feature values and the walking limb feature values.

Abstract: Apparatus and methods are described, including apparatus for use with a subject who shares a bed with a second person. A motion sensor detects motion of the subject and motion of the second person, and generates a motion signal in response thereto. A control unit identifies components of the motion signal that were generated in response to motion of the subject, by distinguishing between components of the motion signal that were generated in response to motion of the subject, and components of the motion signal that were generated in response to motion of the second person. The control unit analyzes the components of the motion signal that were generated in response to motion of the subject and generates an output in response thereto. Other applications are also described.

Abstract: An example operation includes one or more of receiving, by a computer associated with a transport, a gait of an individual from at least one sensor associated with the transport, validating, by the computer, the gait when the gait has corresponding frequency occurrence statistics above a predetermined gait threshold, responsive to the validating, providing, by the computer, access to the transport by the individual, receiving, by the computer, a sequence of gestures of the individual from at the at least one sensor, wherein the sequence of gestures corresponds to a function, validating, by the computer, the sequence of gestures, and responsive to the validating, performing, by the computer, the function responsive to the sequence of gestures being recognized as a known match with a pattern stored in memory.

Abstract: A neuromuscular test device for assessing a level of neuromuscular blocking agents (NMBAs) in an anesthetized patient includes a stimulation circuit for initiating a muscular stimulus in a muscle structure, and a testing circuit for measuring an activity level responsive to the muscular stimulus. A flexible, closed vessel is responsive to a musculature response for inducing a pressure, and a pressure sensor in communication with the closed vessel generates a pressure signal indicative of the musculature response to the muscular stimulus.

Abstract: A method, a structure, and a computer system for assessing user mobility. The exemplary embodiments may include collecting mobility data corresponding to a user and extracting one or more low level features from the mobility data. The exemplary embodiments may further include extracting one or more clinical level features from the low level features and assessing one or more health conditions of the user based on applying one or more models to the one or more clinical level features.

Abstract: A measurement unit is attached to a measurement subject and measures acceleration in time series. A body movement calculation unit obtains the magnitude of body movement indicating the magnitude of a motion of the measurement subject based on acceleration measured by the measurement unit. A singular point extraction unit extracts, as a singular point, a time point at which the magnitude of body movement obtained by the body movement calculation unit exceeds a threshold value. A matching unit rectifies a change in a photoacoustic signal between before and after the singular point extracted by the singular point extraction unit.

Abstract: A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

Abstract: An electronic ankle monitor, a process for a control unit of an electronic ankle monitor, as well as to a process for detecting alcohol in sweat are provided. The electronic ankle monitor (10) includes an electrochemical sensor (11) and an electrically operated heating element (12) for heating skin (20) in an area around the electrochemical sensor.

Abstract: In one embodiment, a cerebrospinal fluid detection system includes a detection device including a detection compartment containing one or more indicators configured to indicate whether or not fluid received within the compartment contains cerebrospinal fluid and a port configured to pass fluid aspirated from a patient into the compartment.