Abstract: A Progressive Lens Simulator comprises an Eye Tracker, for tracking an eye axis direction to determine a gaze distance, an Off-Axis Progressive Lens Simulator, for generating an Off-Axis progressive lens simulation; and an Axial Power-Distance Simulator, for simulating a progressive lens power in the eye axis direction. The Progressive Lens Simulator can alternatively include an Integrated Progressive Lens Simulator, for creating a Comprehensive Progressive Lens Simulation. The Progressive Lens Simulator can be Head-mounted. A Guided Lens Design Exploration System for the Progressive Lens Simulator can include a Progressive Lens Simulator, a Feedback-Control Interface, and a Progressive Lens Design processor, to generate a modified progressive lens simulation for the patient after a guided modification of the progressive lens design.

Abstract: A method and an apparatus for capturing a visual field of a person having a scotoma, in particular a central scotoma, are disclosed. The method includes continuously capturing the eye alignment of the person with a capturing unit, sampling the visual field of the person point-by-point to determine points suitable and not suitable for sight in the visual field of the person, finding the scotoma as a region with a multiplicity of points not suitable for sight, calculating an outer boundary line of the scotoma, calculating an outer enveloping curve, which surrounds the outer boundary line of the scotoma at a predetermined distance, and displaying the outer enveloping curve on a display unit. The enveloping curve is perceivable by the person on the display unit as a frame of the scotoma.

Abstract: A Progressive Lens Simulator comprises an Eye Tracker, for tracking an eye axis direction to determine a gaze distance, an Off-Axis Progressive Lens Simulator, for generating an Off-Axis progressive lens simulation; and an Axial Power-Distance Simulator, for simulating a progressive lens power in the eye axis direction. The Progressive Lens Simulator can alternatively include an Integrated Progressive Lens Simulator, for creating a Comprehensive Progressive Lens Simulation. The Progressive Lens Simulator can be Head-mounted. A Guided Lens Design Exploration System for the Progressive Lens Simulator can include a Progressive Lens Simulator, a Feedback-Control Interface, and a Progressive Lens Design processor, to generate a modified progressive lens simulation for the patient after a guided modification of the progressive lens design. A Deep Learning Method for an Artificial Intelligence Engine can be used for a Progressive Lens Design Processor.

Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

Abstract: An ophthalmic technician is present with a patient in an exam room to operate eye examination equipment and transmit patient information to remote location. At that remote location, a skilled technician is present to provide the necessary optical care, and may operate the phoropter from the remote location. Using video and/or teleconferencing equipment and a phoropter located in the patient examination room along with management software, the system works to determine the final optical prescription for the patient. That information, coupled with findings from other devices which are integrated with the management software, and that the patient uses locally, are reviewed by a remote-based optometrist or ophthalmologist.

Abstract: An optical coherence tomographic (OCT) system includes a sample arm, a reference arm and an OCT probe. The probe irradiates a bodily lumen and a fluid contained within the bodily lumen with light of a sample beam transmitted through a double-clad fiber (DCF). A first detector detects light of a reference beam and light reflected from the bodily lumen and propagated through the core of the DCF to generate OCT interference signals. Light backscattered by the bodily lumen and by the fluid contained in the bodily lumen is propagated through a cladding of the DCF and detected by a second detector to generate an intensity signal. A processor analyzes the intensity signal, and triggers a pullback of the probe and initiates recording of OCT images of the bodily lumen in response to the intensity the backscattered light reaching a predetermined threshold value.

Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.

Abstract: A photoacoustic flow cytometry (PAFC) device for the in vivo detection of cells circulating in blood or lymphatic vessels is described. Ultrasound transducers attached to the skin of an organism detect the photoacoustic ultrasound waves emitted by target objects in response to their illumination by at least one pulse of laser energy delivered using at least one wavelength. The wavelengths of the laser light pulse may be varied to optimize the absorption of the laser energy by the target object. Target objects detected by the device may be unlabelled biological cells or cell products, contrast agents, or biological cells labeled with one or more contrast agents.

Abstract: A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.

Abstract: A first signal is generated with a first light detector in response to an ultrasound signal encountering a first measurement beam. A second signal is generated with a second light detector in response to the ultrasound signal encountering a second measurement beam. The second measurement beam propagates through the sample and the first measurement beam propagates outside the sample.

Abstract: A system and method of tracking activity includes a motion sensor, a light source and a light detector. The light detector is configured to capture an amount of the light that is reflected back to the light detector, at least a first portion of the light reflected back to the light detector is reflected from a blood vessel disposed under a skin adjacent to the housing. A processor is in communication with the motion sensor and the light detector and can process the reflected light to identify heart beats and produce an indication of a heart rate. The indication of the heart rate can be displayed on the display screen as an option, in addition to the metrics that quantify the motion data.

Abstract: The present invention is for a method and system for pain classification and monitoring optionally in a subject that is an awake, semi-awake or sedated.

Abstract: A wearable physiological sensor has a housing and a gas-permeable support structure carried by the housing, which contacts the skin of the subject. An air space is provided between the support structure and the housing. Movement of the support structure relative to the housing is sensed. This provides a sensor which is comfortable for the subject and provides good sensitivity in that motion being detected (e.g. an arterial pulse) only needs to impart kinetic energy to the support structure, with a relatively low inertia.

Abstract: A remote photoplethysmography (RPPG) system includes an input interface to receive a sequence of measurements of intensities of different regions of a skin of a person indicative of vital signs of the person; a solver to solve an optimization problem to determine frequency coefficients of photoplethysmographic waveforms corresponding to the measured intensities at the different regions, wherein the solver determines the frequency coefficients to reduce a distance between intensities of the skin reconstructed from the frequency coefficients and the corresponding measured intensities of the skin while enforcing joint sparsity on the frequency coefficients; and an estimator to estimate the vital signs of the person from the determined frequency coefficients of photoplethysmographic waveforms.

Abstract: Light is irradiated to a finger of a subject and received from the finger of the subject to extract a pulse wave signal, generates an optimized pulse wave signal in a desired type by sampling the extracted pulse wave signal according to a predetermined sampling condition and normalizes the generated pulse wave signal, the entire segment of the normalized pulse signal is divided into a plurality of window segments to detect a pulse wave amplitude value with respect to a pulse wave signal for each window, a first eigenvector for each subject corresponding to a pulse wave amplitude value of the entire window segment is extracted by using a linear discriminant analysis and then the first eigenvector per subject is compared with a threshold, determines distribution of eigenvectors for each subject compared to the threshold and thus a characteristic of the corresponding subject is diagnosed.

Abstract: Embodiments of the invention are directed to a photoplethysmogram (PPG) structure that includes a wearable component and a network of PPG sensors physically coupled to the wearable component. Each PPG sensor of the network includes a housing, a first light source and a light detector. The first light source is positioned in or on the housing such that, when the housing is positioned on a surface, the housing positions an illuminating surface of the first light source at a predetermined first-light-source angle with respect to the surface.

Abstract: A biological information measurement device includes: a pulse wave detection unit that continuously detects pulse waves from a living body; a biological information calculation unit that calculates biological information based on pulse waves detected by the pulse wave detection unit and stores, in a storage medium, biological information calculation results information including said biological information; a storage control unit that stores, in the storage medium, pulse wave detection results information by the pulse wave detection unit in order to calculate biological information included in biological information calculation results information; a measurement efficiency information generation unit that generates measurement efficiency information indicating measurement efficiency for biological information included in biological information calculation results information, generating same based on the biological information calculation results information and pulse wave detection results information; and a

Abstract: A system and method is configured for use with an endoscope, a biopsy needle, and a data acquisition system. The system includes a sensor tip and a pressure sensor coupled to the sensor tip and having at least one piezo-resistor component with an internal-facing side and an external-facing side, and an opening adjacent to the at least one piezo-resistor component to allow fluid access to the internal-facing side and the external-facing side. The system also includes a tubing member with a distal end and a proximal end, the sensor tip coupled to the distal end, the sensor tip and the tubing member configured to be routed through the biopsy needle and connection elements coupled to the proximal end of the tubing member, the connection elements configured to mount the tubing member relative to the biopsy needle and to couple the pressure sensor to the data acquisition system.

Abstract: Embodiments of the present disclosure provide methods, apparatuses, devices and systems for measuring vital signs in human and animals by interrogating electromagnetic signals reflected from tissues in a human or animal subject. Probes may transmit radio frequency electromagnetic waves into a living body and generate signals responsively to the waves that are scattered from within the body. Such embodiments may be suitable for wearable devices as well as for use by medical practitioners.

Abstract: A respiration monitoring system has deformation transducers on a flexible substrate arranged to adhere to a patient's torso. A processor receives signals in channels from the transducers and processes them to eliminate, reduce or compensate for noise arising from patient motion artefacts, to provide an output representative of respiration. The transducers have a size and a mutual location on the substrate so that a first transducer can overlie at least part of the 10th rib and a second transducer can overlie at least part of the 11th rib or the abdomen, and the processor processes data from the first transducer as being primarily representative of rib distending respiration and from the second transducer as being primarily representative of either diaphragm respiration or patient motion artefacts.

Abstract: A fluid dynamic valve passively allows fluid flow out of a moving stream in one flow direction and not in the reverse. This allows the collection of fluid from a single direction of an AC fluid flow. The siphoned portion of the flow has a flow rate proportional to the mainstream flow. This device can collect exhaled breath or selective entrenchment during inhale. In one orientation, it can meter aerosolized particles into an inhale breath stream for pulmonary delivery, without complicated breath timing or drug loss due to drug adsorption to the back of the throat. Alternatively, a user can breathe through the device and a proportional amount, relative to the volumetric flow rate, of each exhale can flow into an auxiliary chamber for analysis. In addition, the device has a low respiratory burden and is comfortable to use.

Abstract: A system and method for automated body mass index is disclosed. The disclosed method operates within a system architecture including one or more computing devices, one or more servers, and one or more databases. A processor operating within the one or more servers executes one or more algorithms for detecting relevant features associated with a potential client's multimedia information. The method may include calculating feature values, such as abdomen circumference, face width, face height, cheekbone width, jaw width, and neck width, and the like as well as calculating the body mass index of the potential client using one or more regression algorithms. A baseline and updated BMI may be determined, and used for determining a baseline and updated value.

Abstract: A vital sign information recording system includes a data collector configured to collect behavior-associated information of a subject and vital sign information of the subject, and a display configured to display a presumed behavior of the subject and the vital sign information of the subject. At least one of the data collector and the display has a controller configured to determine the presumed behavior of the subject based on the behavior-associated information, and to display the presumed behavior of the subject and the vital sign information of the subject in a mutually associated manner on the display.

Abstract: Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject.

Abstract: Disclosed are a method and device for detecting the concentration of total hemoglobin in blood. A differential path factor corresponding to a subject is determined according to a physiological parameter of the subject and a predetermined table of a corresponding relation between the physiological parameter and the differential path factor.

Abstract: An apparatus and method for non-invasively determining the blood oxygen saturation within a subject's tissue by near-infrared spectroscopy is disclosed. Embodiments of the apparatus and method use the multi-distance method and take into account the attenuation of the light signal due to light absorbers other than hemoglobin and deoxyhemoglobin and the scattering properties of a subject's tissue.

Abstract: A sensor (1) for detection of gas, in particular for detection of CO2. The sensor (1) has a contact face (2) which is directed towards a measuring site. The sensor (1) includes at least one radiation source (3), a measurement volume (4) for receiving the gas to be measured, and at least a first detector (5) for detection of radiation transmitted from the source (3) to the first detector (5) through the measurement volume (4). The sensor has a path (6) of the radiation between radiation source (3) and first detector (5). The radiation propagates along the path in a non-imaging way.

Abstract: In some embodiments, an electrochemical sensing system includes a working electrode and a reference electrode. At least a portion of the working electrode includes rhodium. An electrical circuit is electronically coupled to the working electrode and the reference electrode. The electrical circuit is configured to bias the working electrode at voltage of less than about 0.4 V which is sufficient to electrochemically decompose a target analyte, and to measure a current corresponding to the concentration of the target analyte. In some embodiments, a biosensing molecule can be disposed on the working electrode and is operative to catalytically decompose a non-electroactive target analyte to yield and an electroactive by-product. In some embodiment, the reference electrode can include rhodium and its oxides.

Abstract: Disclosed herein are systems and methods for providing a compressible interconnect for allowing electrical communication between an electronics unit and an analyte sensor in an on-body analyte monitoring device. In other embodiments, systems and methods are provided for reducing the Z-height of an on-body analyte monitoring device by utilizing novel interconnects.

Abstract: Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.

Abstract: An apparatus includes a pre-sample reservoir, a diversion mechanism, and a flow metering mechanism. The diversion mechanism has an inlet port couplable to a lumen-defining device to receive bodily-fluids from a patient, a first outlet port fluidically couplable to the pre-sample reservoir, and a second outlet port fluidically couplable to a sample reservoir. The diversion mechanism defines a first fluid flow path and a second flow path that are configured to place the first outlet port and the second outlet port, respectively, in fluid communication with the inlet port. The flow metering mechanism is configured to meter a flow of a predetermined volume of bodily-fluid through the first fluid flow path into the pre-sample reservoir, to meter a flow of a second volume of bodily-fluid through the second fluid flow path into the sample reservoir, and to display a volumetric indicator associated with the predetermined volume and the second volume.

Abstract: Computing devices, methods and computer-readable mediums for providing guided meditation to patients based on results of a psychological test are provided herein. Contemplated computing devices can comprise a processor, a memory for storing a computer-readable medium comprising computer-readable instructions stored therein, wherein the instructions are executable by the processor to serve psychological tests to the patient through a virtual patient portal, transform results of the psychological tests into sets of psychological conditions of the patient, match predefined meditation paths to the patient and serve guided meditation tracks in the matched meditation paths to the patient through the virtual patient portal.

Abstract: Subject matter disclosed herein may relate to systems, devices, and/or processes for processing signals and/or states representative of behavioral and/or biological state.

Abstract: In an aspect of the invention, a method of identifying sensory inputs affecting working memory load of an individual is provided. The method comprises monitoring (S101) working memory load of the individual using a sensor device, detecting (S102) an increase in the working memory load of the individual, and identifying (S103), in response to the detected increase, at least one sensory input affecting the working memory load of the individual.

Abstract: A system for the integrated/functional detection of different measurements is described. The system comprises a part wearable by a driver of a vehicle and plurality of sensors integrated in the wearable part and configured to supply the following driver parameters: breathing parameters, heart parameters, perspiration parameters and of the pressure exerted on the vehicle driving wheel. The system also includes a processor for processing the driver parameters and correlating them to a driver psychophysical condition.

Abstract: A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.

Abstract: Techniques for sensing neural responses such as Evoked Compound Action Potentials (ECAPs) in an implantable stimulator device are disclosed. A first therapeutic pulse phase is followed by a second pulse phase, which phases may be of opposite polarities to assist with active charge recovery. The second pulse phase is formed so as to overlap in time with the arrival of the ECAP at a sensing electrode, which second phase may generally be longer and of a lower amplitude. In so doing, a stimulation artifact formed in a patient's tissue is rendered constant, and of a smaller amplitude, when the ECAP is sensed at the sensing electrode, which eases sensing by a sense amp circuit. Passive charge recovery may follow the second phase, which will not interfere with ECAP sensing that has already occurred.

Abstract: An apparatus for generating ECG recordings and a method for using the same are disclosed. The apparatus includes a handheld device having four electrodes on an outer surface thereof, the handheld device having an extended configuration and a storage configuration. The apparatus also includes a controller configured to measure signals between the electrodes to provide signals that are used to generate an ECG recording selected from the group consisting of standard lead traces and precordial traces. When the handheld device is in the extended configuration and the first and second electrodes contact a first hand of a patient such that the first and second electrodes contact different locations on the first hand, the third electrode is in contact with a location on the patient's other hand and the fourth electrode contacts a point on the patient's body that depends on the particular trace being measured.

Abstract: Electrodes for use in electroencephalographic recording, including consciousness and seizure monitoring applications, have novel features that speed, facilitate or enforce proper placement of the electrodes, including aligning tabs and arrowed aligning juts, color coding, and an insulating bridge between reference and ground electrodes which ensures a safe application distance between the conductive regions of the two electrodes in the event of cardiac defibrillation or to prevent shorting between the adjacent electrodes by preventing the conductive path to be shared. A method of using a set of four such electrodes is also disclosed.

Abstract: A system and method for detecting and verifying bradycardia/asystole episodes includes sensing an electrogram (EGM) signal. The EGM signal is compared to a primary threshold to sense events in the EGM signal, and at least one of a bradycardia or an asystole is detected based on the comparison. In response to detecting at least one of a bradycardia or an asystole, the EGM signal is compared to a secondary threshold to sense events under-sensed by the primary threshold. The validity of the bradycardia or the asystole is determined based on the detected under-sensed events.

Abstract: A neuromonitoring system utilizes transcutaneous, trans-abdominal nerve root stimulation to monitor the health and status of the motor neural pathways of the lower extremities during the portions of a surgical procedure in which a tissue retraction assembly is used to maintain an operative corridor. A method of monitoring the status of nerve during a spinal surgical procedure delivers a transcutaneous, trans-abdominal stimulation signal to the spine. A determination is made of a stimulation threshold required to elicit a neuromuscular response from the stimulation signal.

Abstract: Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.

Abstract: The invention generally relates to medical kits, e.g., an immunotherapy treatment and testing kits, and more particularly to a method of using the kits and system for treating allergies.

Abstract: The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin.

Abstract: A method of measuring a characteristic of a skin, including varying an air pressure in a chamber positioned adjacent to a skin, in which the chamber has an opening that exposes the skin to changes in the air pressure in the chamber. A plurality of measurements of surface profiles of the skin are made over a period of time as the surface profile of the skin varies in response to changes in the air pressure.

Abstract: The present disclosure generally relates to the field of temporal and spatial risk mapping and risk response. More particularly, the present disclosure relates to spatial and temporal mapping of outcomes, risk analysis, and responsive and preventative actions derived through artificial intelligence driven workflow augmentation using spatial and temporal data mapping of data from a plurality of historical and streaming data sources.

Abstract: A method for identifying human joint characteristics, the method including the steps of: using a mobile imaging device, taking at least one image of the joint, and then identifying a joint pain location by identifying three different locations in the image near the joint, so that a center point between the locations can be triangulated.

Abstract: Apparatus for providing transcutaneous electrical nerve stimulation (TENS) therapy to a user, the apparatus comprising: a housing; an application unit for providing mechanical coupling between the housing and the user's body; a stimulation unit for electrically stimulating at least one nerve of the user; a sensing unit for sensing the user's body movement and body orientation; and a reporting unit for providing the user with feedback based on the user's sensed body movement and body orientation.

Abstract: An autonomous drug delivery system advantageously utilizes physiological monitor outputs so as to automatically give a bolus of a rescue drug or other necessary medication when certain criteria and confidence levels are met. An emergency button is provided to manually trigger administration of the rescue drug. The rescue drug may be an opioid antagonist in response to an analgesia overdose, a hypotensive drug to avert an excessive drop in blood pressure or an anti-arrhythmia drug to suppress abnormal heartbeats, to name a few.

Abstract: Methods and systems are provided for monitoring neuromuscular blockade in patients during surgical procedures. In one embodiment, a system includes a stimulator, an electromyography (EMG) sensor, a kinemyography (KMG) sensor, and a single connector configured to couple each of the stimulator, the EMG sensor, and the KMG sensor to a patient monitoring device via a single input. In this way, neuromuscular transmission (NMT) monitoring in patient may be done reliably by ensuring that NMT measurement from a first sensor (EMG sensor) is in line with the measurement of the second sensor (KMG sensor).